Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| in situ hybridization study on human papillomavirus dna expression in benign and malignant squamous lesions of the esophagus. | histologic changes suggesting hpv infection are occasionally found adjacent to squamous cell carcinoma or in squamous papilloma of the esophagus, but the relationship between hpv infection and benign and malignant squamous lesions of the esophagus is not yet dear. the aim of this study was to examine the role of hpv in squamous lesions of the esophagus. microscopic examination with emphasis on hpv infection was done on 15 cases of squamous cell carcinoma and 26 cases of squamous papilloma. in si ... | 1996 | 9008094 |
| properties of hpv-positive and hpv-negative anal carcinomas. | evidence of human papillomavirus (hpv) can be found in up to 85 per cent of anal carcinomas. in the vulva, a discrete subset of hpv-positive carcinomas which show koilocytic morphology and distinct clinical features has recently been identified (warty carcinoma). the morphological and prognostic features of hpv-positive and hpv-negative anal carcinomas were compared in this study of the tumour distribution of hpv dna. vulval and anal neoplasia are similar in many ways and we have also looked to ... | 1996 | 9014857 |
| epstein-barr virus nuclear antigen (ebna)3c is an immortalizing oncoprotein with similar properties to adenovirus e1a and papillomavirus e7. | epstein-barr virus (ebv) requires six genes to efficiently immortalize human b cells. we have shown that one of these, ebna3c, can cooperate with activated (ha-)ras in co-transfection assays to immortalize and transform rat embryo fibroblasts (refs). ebna3c also augmented transformation by (ha-)ras and a mutant p53 to a similar extent as human papilloma virus e7. as with e7 this effect was not inhibited by cotransfection with the cyclin-dependent kinase inhibitor (cdki), a p16ink4a, which can no ... | 1996 | 9000128 |
| presence of human papillomavirus type 6f in tonsillar condyloma acuminatum and clinically normal tonsillar mucosa. | an attempt was made to detect human papillomavirus (hpv) in 8 cases of oral papilloma by southern blot hybridization. hpv type 6 was identified in a case of tonsillar condyloma acuminatum, but neither hpv type 6 nor 11 was found in the 7 other cases of squamous papilloma. the hybridization pattern of the hpv type 6 dna after digestion with restriction enzymes revealed that the hpv was of the 6f subtype. dna samples isolated from the condyloma acuminatum, 3 peripheral specimens of clinically norm ... | 1996 | 9001342 |
| infection of human papillomavirus (hpv) and p53 over-expression in human female genital tract carcinoma. | inactivation of p53 gene products either by mutation or by complex formation with e6 oncoprotein encoded by high risk hpv appears to be a common event in cervical carcinogenesis. this study was designed to clarify this association in 41 primary cervical, 15 endometrial, 3 ovarian and one rectal carcinomas. polymerase chain reaction analysis revealed presence of high risk hpv in 36 (88%) cervical, 5 (33%) endometrial and none of ovarian and rectal carcinomas. hpv 16 was found in 14 cervical carci ... | 1996 | 8961706 |
| [human papilloma virus. epidemiologic, carcinogenic, diagnostic and therapeutic aspects]. | human papillomavirus (hpv) is the most common infection among women. natural history of hpv infection has changed as well as diagnosis and treatment. clinical picture is variable even with spontaneous remission. molecular biology for diagnosis and typification of hpv has changed its treatment. the disease can be treated according to clinical experience. sometimes can not eradicated since just it is impossible make to disappear it from genital tract. | 1996 | 8964543 |
| p53-null cells are more sensitive to ultraviolet light only in the presence of caffeine. | we have shown previously that p53(-/-) fibroblasts show greater sensitization by caffeine to the lethal effects of ionizing radiation compared with p53(+/+) cells. recently published data have suggested a possible role of p53 in nucleotide excision repair: an association of p53 and xeroderma pigmentosum group b protein and a greater sensitivity to cisplatin of rko cells transfected with the e6 protein of human papilloma virus (inactivating p53). we show that p53(+/+) and p53(-/-) cells have equa ... | 1996 | 8968086 |
| a neglected lesbian health concern: cervical neoplasia. | many health care providers believe that lesbian women do not need routine papanicolaou smears. this erroneous assumption fails to recognize that the majority of lesbian women have had prior heterosexual relationships and thus may be at risk for developing cervical neoplasia. the following case report describes a lesbian woman who denied prior heterosexual intercourse but who developed cervical intraepithelial neoplasia grade 2 (cin 2) associated with a high oncogenic risk human papillomavirus (h ... | 1996 | 8969707 |
| e5 proteins of human papillomavirus types 11 and 16 transactivate the c-fos promoter through the nf1 binding element. | human papillomavirus type 11 (hpv-11) and hpv-16 contain an e5 gene that can induce c-fos gene expression in mouse fibroblasts. this study investigated the human c-fos promoter characteristics by mapping the c-fos promoter sequence with several deletion and point mutants that confer responsiveness to e5 of hpv-11 or hpv-16. the mutant studies show that nf1 binding sequences within the c-fos promoter were crucial for the induction of the c-fos gene by e5, and the gel shift assay study suggested t ... | 1996 | 8970980 |
| human papillomavirus vaccines. | 1996 | 8971215 | |
| improved detection of human papillomavirus infection in genital intraepithelial neoplasia in human immunodeficiency virus positive (hiv +) women by polymerase chain reaction-in situ hybridization. | the prevalence of genital human papillomavirus (hpv) infection was evaluated in 30 consecutive human immunodeficiency virus (hiv) + women by polymerase chain reaction (pcr)-in situ hybridization (ish) on paraffin-embedded tissue sections and compared with that found with standard ish. biopsies were removed from normal or neoplastic areas in the cervix, vagina, and vulva, and ish was performed with biotinylated or fluorescein isothiocyanate genomic dna probes. one probe was used for hpv screening ... | 1996 | 8727101 |
| hiv-1, hiv-2, human papillomavirus infection and cervical neoplasia in high-risk african women. | to determine the effect of hiv-1 and hiv-2 infection on the prevalence of cervical human papillomavirus (hpv) and squamous intraepithelial lesions (sil) in a population of high-risk women in senegal. | 1996 | 8728046 |
| papillomaviruses and potential copathogens. | an in vitro multistage genital epithelial cell model for cervical cancer that parallels the in vivo neoplastic process has been developed using recombinant human papillomavirus (hpv) dna and genital cells. hpv-16-immortalized genital cells are responsive to the genotoxic action of known chemical carcinogens (polycyclic hydrocarbons, alkylating agents or cigarette smoke condensate), but are not converted to malignancy. ras oncogene and human herpes virus-2 did convert hpv immortalized cells to ma ... | 1996 | 8920709 |
| up-regulation of hormone response of human papillomavirus type 16 expression and increased dna-protein binding by consensus mutations of viral glucocorticoid response elements. | human papillomaviruses (hpvs) and steroid hormones are linked to the development of cervical cancer. studies from our laboratory and others showed that the steroid glucocorticoid and progesterone hormones activated the expression of hpv type 16. this activation was attributed to the specific interaction of the glucocorticoid receptor (gr) with the three glucocorticoid response elements (gres) in the hpv16 regulatory region. in the present study, we first examined the glucocorticoid response medi ... | 1996 | 8923291 |
| [retrospective study of cervical papillomavirus lesions: early herpes simplex virus proteins as markers of risk for progression]. | specific types of human papillomavirus (hpv) are currently implicated as etiologic agent of benign and malignant lesions of the genital tract. previous studies highlighted the presence of early proteins (icsp 11/12) of herpes simplex virus type 2 (hsv-2) mainly in hpv infected lesions of the cervix. this paper reports a retrospective study on the clinical course of benign cervical alterations in a 70 women population followed-up for 24 months. hpv and hsv-2 (late and early) antigens were detecte ... | 1996 | 8927276 |
| [maternal-fetal transmission of human papillomavirus]. | human papilloma virus (hpv) infection is one of the most frequently observed sexually-transmitted diseases (10-60% of the general population). in pregnant women, as well as accelerating the evolution of dysplasia to cervical cancer, the infection may be transmitted to the fetus during gestation or at the time of birth. children who have been infected at birth may develop laryngeal papillomatosis during the first 5 years of life that may, in some cases, spread to the point of causing aphonia or s ... | 1996 | 8927279 |
| p53 protein expression in esophageal squamous cell papillomas: a study of 36 lesions. | in the present study 36 esophageal squamous cell papillomas (escp), uncommon benign neoplasms of the esophagus, were investigated retrospectively for p53 immunoreactivity by using the monoclonal antibody pab 1801. two escps had previously been found to be human papillomavirus (hpv) type-6-positive. | 1996 | 8927934 |
| cytokine regulation of the matrix metalloproteinases and their inhibitors in human papillomavirus-18 transformed human prostatic tumor cell lines. | cytokines may play a critical role in influencing the invasive and metastatic behavior of advanced cancers. to investigate the influence of cytokines on tissue inhibitor of metalloproteinase (timp) and matrix metalloproteinase (mmp) expression we have established cultures from prostate tissues of low gleason sum 5 and high gleason sum 10 cancers. we have examined the influence of different cytokines (interleukin [il]-10, il-4, il-6, il-2, and interferon-gamma) on timp-2, mmp-2, and mmp-9 protein ... | 1996 | 8938794 |
| induction of the hpv16 enhancer activity by jun-b and c-fos through cooperation of the promoter-proximal ap-1 site and the epithelial cell type--specific regulatory element in fibroblasts. | the epithelial cell type-specific enhancer of the human papillomavirus (hpv) type 16 termed the long control region (lcr) carries three ap-1 binding sites. we investigated the roles of the ap-1 sites for transactivation of the lcr by jun-b that may be a cell type specific-transactivator for the hpvs in human fibroblasts in which expression of the endogenous jun-b gene is low. transient expression of jun-b alone poorly activated transcriptional activity of the lcr. however, when combined with c-f ... | 1996 | 8938978 |
| [local immune responses in uterine cervical carcinogenesis]. | in order to investigate the role of local immune response in uterine cervical carcinogenesis, lymphocyte phenotypes infiltrating the cervical region were studied by indirect immunoperoxidase staining for natural killer (nk) cells, macrophages. langerhans cells (lc), memory t cells, cd4-positive cells and cd8-positive cells. the specimens used in this study were 9 normal ectocervical epithelium samples, 28 with mild dysplasia, 28 with moderate dysplasia, 31 with severe dysplasia and 9 with carcin ... | 1996 | 8940695 |
| human papillomavirus dna in squamous cell carcinoma of the lung. | to compare the incidence of squamous cell carcinoma (scc) of the lung in okinawa with that in niigata on the mainland. | 1996 | 8943746 |
| different hla-dr-dq haplotypes are associated with cervical intraepithelial neoplasia among human papillomavirus type-16 seropositive and seronegative swedish women. | to analyze whether hla may be a determinant of the risk of developing cervical cancer precursor lesions, the association between hla and cervical neoplasia among hpv16-seropositive and -negative subjects was determined in a population-based cohort in the västerbotten county of northern sweden. hla genotyping of dr and dq was done by pcr in 74 patients and 164 healthy controls matched for age, sex and area of residence. the presence of dqa1*0102 was weakly associated with cervical neoplasia in hp ... | 1996 | 8945607 |
| risk factors for hpv dna detection in middle-aged women. | strong epidemiologic evidence indicates that human papillomavirus (hpv) is the main etiologic factor of cervical cancer. a few cohort studies suggest that most hpv infections are transient in young women and that persistent hpv infections are more common in older women. little is known about the determinants of persistent hpv infections. the present study was aimed at increasing our knowledge about these determinants. | 1996 | 8946637 |
| genetic predisposition and parameters of malignant progression in k14-hpv16 transgenic mice. | reproducible multi-stage progression to invasive squamous carcinoma of the epidermis has been achieved in transgenic mice expressing the hpv16 early-region genes, including the e6/e7 oncogenes, under the control of the human keratin-14 promoter/enhancer. although 100% of k14-hpv16 transgenic animals develop hyperplastic and/or dysplastic lesions in several inbred backgrounds, including c57bl/6, balb/c, and ssin/sencar, only mice backcrossed into the fvb/n background progress to malignant squamou ... | 1996 | 8952526 |
| [detection of human papillomavirus by polymerase chain reaction in primary lung carcinoma]. | human papillomaviruses (hpv) have been implicated in the pathogenesis of human squamous cell carcinoma, specially of cervical carcinomas. in previous studies concerning primary lung cancer, dna of hpv subtypes was detected by in situ hybridization or polymerase chain reaction (pcr), up to 30% of the cases, namely in squamous cell carcinomas. a series of 31 frozen biopsies of lung carcinomas (surgical biopsies or through fiber optic bronchoscopy) were examined for the presence of hpv dna by neste ... | 1996 | 8952634 |
| synthesis, properties and applications of papillomavirus-like particles. | papillomavirus-like particles can be obtained by expression of the major capsid protein l1 alone or by coexpression with the minor capsid protein l2 in various systems. virus-like particles (vpls) and virions have very similar capsid structures. immunization with vlps yields antibodies neutralizing virions in vitro. vaccination of animals with vlps has been shown to protect against viral challenge. vlps of human papillomavirus (hpv) are therefore the most promising vaccine candidate to prevent i ... | 1996 | 8957669 |
| surrogate end points in cancer research: a critique. | studies using surrogate end points of malignant disease may be smaller, shorter, and less expensive than studies with incident cancer end points. researchers have proposed a broad range of histological, cellular, and molecular markers as surrogate end points for cancer (secs). we define a valid sec as follows: the effect of an intervention on (or the association of a risk factor with) the sec is concordant with its effect on (or association with) incident cancer. adenomatous polyps and persisten ... | 1996 | 8959315 |
| identification of domains required for transcriptional activation and protein dimerization in the human papillomavirus type-16 e7 protein. | to analyse the potential of the e7 oncogene of hpv-16 to activate transcription, we constructed hybrid proteins containing various portions of the hpv-16 e7 protein fused to the dna binding region of the bacterial lexa repressor. we found that full length hpv-16 e7 is capable to mediate activation of two different reporter genes, which carry lexa binding sites in their promoters. in contrast, e7 from hpv-11, a low-risk type papillomavirus, was unable to activate transcription, when analysed in t ... | 1996 | 8552395 |
| human papillomavirus dna as a factor determining the survival of bladder cancer patients. | the natural history of transitional cell carcinoma (tcc) of the urinary bladder is somewhat variable, with a significant number of tumour recurrences that occasionally evolve towards an infiltrating disease. the aim of this study was to investigate the presence of human papillomavirus (hpv) dna in 76 tcc specimens, and then correlate such findings with the overall patient survival. however, other classical prognostic clinical and pathological variables such as pathological grade and stage, koilo ... | 1996 | 8554974 |
| human papillomavirus is associated with the frequent detection of warty and basaloid high-grade neoplasia of the vulva and cervical neoplasia among immunocompromised women. | a total of 158 women who either hiv-infected or under iatrogenic immunosuppression were examined regularly during a 4-year period to evaluate if certain vulvar neoplasms and cervical neoplasia have similar associated risk factors. patients with cin were matched prospectively with immunocompetent controls with cin. forty-eight cervical lesions were detected among patients, including 2 invasive carcinoma and 15 cin-3 lesions, compared to 11 vulvar lesions, including 2 invasive carcinoma and 7 vin- ... | 1996 | 8557224 |
| occasional memory cytotoxic t-cell responses of patients with human papillomavirus type 16-positive cervical lesions against a human leukocyte antigen-a *0201-restricted e7-encoded epitope. | most cervical carcinoma (cxca) cells constitutively express human papillomavirus type 16 (hpv16) e6 and e7 oncoproteins. these proteins are, therefore, attractive targets for t cell-based immunotherapy. previously, we identified hvp16 e7-encoded ctl epitopes. in patients with cervical intraepithelial neoplasia or cxca, little is known concerning t-cell activity against viruses in general and against hpv16 in particular. here, we have screened the blood of 10 healthy donor controls and of 22 pati ... | 1996 | 8564975 |
| p53-mediated radioresistance does not correlate with metastatic potential in tumorigenic rat embryo cell lines following oncogene transfection. | changes in wild-type p53 protein function occur in the majority of human tumors, and may alter genomic stability and the cellular response to ionizing radiation. whether oncoproteins can render tumor cells both radioresistant and metastatic, may have implications for clinical strategies designed to improve local tumor control. in the studies reported here, we tested the hypothesis that acquired radioresistance correlates with metastatic potential within a large panel of transformed rat embryo ce ... | 1996 | 8567335 |
| protection against papillomavirus with a polynucleotide vaccine. | genital infections with human papillomavirus (hpv) are increasingly recognized as a significant source of human disease; hpv is now implicated in up to 90% of cervical carcinomas. neutralizing antibodies against papillomaviruses recognize conformational epitopes formed when viral capsid proteins assemble into virions or virus-like particles. immunization with plasmid dna encoding the major viral capsid protein l1 was studied as a means of inducing neutralizing antibodies and protection against v ... | 1996 | 8568291 |
| resistance to retinoic acid and altered cytokeratin expression of human papillomavirus type 16-immortalized endocervical cells after tumorigenesis. | human papillomaviruses (hpvs) and cigarette smoking are epidemiologically associated with cervical cancer. we recently found that hen-16 and hen-16-2 hpv type 16-immortalized endocervical cells form tumors after treatment with cigarette smoke condensate and derived 2 tumor cell line cultures, hen-16t and hen-16-2t, respectively. here, we examine the molecular pathologic effect of tumorigenesis. hen-16t and hen-16-2t exhibit unchanged status and expression of integrated hpv 16 dna. however, the e ... | 1996 | 8575856 |
| human papillomavirus types and cervical cancer. | 1996 | 8592014 | |
| human papillomavirus infection and risk of progression of epithelial abnormalities of the cervix. | the polymerase chain reaction has been used to determine the presence of human papillomavirus (hpv) 16 and hpv 18 dna sequences in archival histological material removed from a cohort of untreated women with cervical epithelial abnormalities. the detection of hpv 16 or hpv 18 dna sequences in the initial biopsy specimen was associated with a significantly increased risk of subsequent disease progression. | 1996 | 8595174 |
| human papillomavirus--the most significant risk determinant of cervical intraepithelial neoplasia. | sexual behavior has been consistently identified as a major risk factor for cervical cancer. population-based studies have demonstrated that risk related to sexual activity is mediated by human papillomavirus (hpv) infection. we conducted a case-control study of 199 cases with low-grade squamous intraepithelial lesions or high-grade squamous intraepithelial lesions as defined by cytology and 1000 control women selected from an ongoing prospective cohort study in copenhagen, denmark. furthermore, ... | 1996 | 8598310 |
| sensitivity of p53 lysine mutants to ubiquitin-directed degradation targeted by human papillomavirus e6. | the activity of the p53 tumor suppressor protein is regulated, at least in part, through the stability of the protein. p53 degradation in normal cells is controlled by ubiquitin-dependent proteolysis, and activation of p53 following dna damage is associated with an increase in the stability of the protein. the human papillomavirus-encoded e6 protein abrogates p53 function by targeting it for rapid degradation, also through the ubiquitin pathway. although the p53 protein is ubiquitinated followin ... | 1996 | 8599213 |
| viral and histopathologic correlates of mn and mib-1 expression in cervical intraepithelial neoplasia. | a recently studied tumor antigen, mn, has been associated with cervical carcinomas and cervical intraepithelial neoplasms (cin), suggesting that it may serve as a marker for cervical cancer or cancer risk. to determine if expression of the mn antigen paralleled parameters reflecting viral or biological events in precursor epithelium, mn expression was correlated with mib-1 expression, morphological phenotype, and human papillomavirus (hpv) distribution and type in a series of cins. seventy-three ... | 1996 | 8600036 |
| sequence conservation within the major capsid protein of human papillomavirus (hpv) type 18 and formation of hpv-18 virus-like particles in saccharomyces cerevisiae. | the major capsid protein l1 of human papillomaviruses (hpvs) has been identified as a promising candidate antigen for a prophylactic hpv vaccine. since amino acid sequence heterogeneity has been demonstrated for the l1 genes within individual hpv types, nucleotide sequences of l1 were determined from six hpv-18 clinical isolates and the cervical carcinoma cell line sw756 and compared to the published hpv-18 prototype sequence. the sequences were almost identical between the clinical isolates and ... | 1996 | 8601783 |
| determinants of persistent detection of human papillomavirus dna in the uterine cervix. | to identify factors associated with persistence of human papillomavirus (hpv) dna in the uterine cervix, 179 women who were 18-49 years old and who had normal cytologies and positive cervical hpv dna test at a routine periodic examination were analyzed. among them, 91 (50.8%) remained hpv-positive a few months (mean, 11 weeks) later. persistence was higher in women who had used oral contraceptives for > or = 2 years (odds ratio, 3.9; 95% confidence interval, 1.5-10.3) compared with those who nev ... | 1996 | 8603956 |
| chronic esophagitis evolving to verrucous squamous cell carcinoma: possible role of exogenous chemical carcinogens. | a patient exposed to aerosolized lye and ingested kerosene was followed up for 16 years with chronic esophagitis before developing verrucous esophageal squamous carcinoma. the aim of this study was to elucidate the pathogenesis of the carcinoma. | 1996 | 8608902 |
| in vitro synthesis of oncogenic human papillomaviruses requires episomal genomes for differentiation-dependent late expression. | human papillomavirus (hpv) types 16, 18, 31, and 51 are the etiologic agents of many anogenital cancers including those of the cervix. these "high risk" hpvs specifically target genital squamous epithelia, and their lytic life cycle is closely linked to epithelial differentiation. we have developed a genetic assay for hpv functions during pathogenesis using recircularized cloned hpv 31 genomes that were transfected together with a drug resistance marker into monolayer cultures of normal human fo ... | 1996 | 8610168 |
| the serine protease inhibitors tlck and tpck react with the rb-binding core of hpv-18 e7 protein and abolish its rb-binding capability. | the human papillomaviruses associated with cervical cancer (e.g., hpv-16 and hpv-18) express an e7 oncoprotein which mediates the immortalization of primary genital keratinocytes and the transformation of rodent cells. the 105-amino-acid hpv-18 e7 protein contains two zinc fingers as well as a conserved amino-terminal motif (rb-binding core) which binds and alters the interactions of the retinoblastoma susceptibility gene product (rb). we report here that two serine protease inhibitors, tosyl-l- ... | 1996 | 8610446 |
| genomic organization of human papillomavirus type 18 in cervical cancer specimens. | it has been reported that cervical cancers positive for human papillomavirus (hpv) 18 have a poorer prognosis than those with other hpv types. to gain a better understanding of the aggressive character of hpv 18-positive cancers, we examined the difference in genomic organization between hpv 18 and hpv 16 harbored in cervical cancers. we amplified e1 and e2 genes from 9 hpv 18-positive and 31 hpv 16-positive cervical cancers by polymerase chain reaction (pcr). at least one of the two early genes ... | 1996 | 8613428 |
| epithelial cells display separate receptors for papillomavirus vlps and for soluble l1 capsid protein. | we examined the distribution of putative receptors for papillomavirus (pv) capsid proteins on various cell types, using either hexahis hpv6b l1 fusion protein or synthetic hpv6b virus-like particles (vlps). specific, saturable binding of vlps to cv-1 cells was demonstrated using 35s-labeled vlps, with an average receptor number of 1 x 10(4)/cell and a binding affinity constant (ka) of 4 x 10(7) m. vlp binding was quantitated by flow cytometry using a monoclonal antibody to the l1 capsid protein. ... | 1996 | 8615005 |
| differences in reactivity to cyclosporin a and interferon-gamma of normal and hpv-transformed keratinocytes. | in humans, cyclosporin a (csa) avoids organ allograft rejection but induces skin carcinomas after long term immunosuppressive treatment; some of these lesions contain human papillomavirus (hpv) dna. interferon-gamma (ifn-gamma) is sometimes used in local treatment of persistent or recurrent lesions in normal population. in vivo, both drugs have an effect on keratinocytes which remains unclear. therefore, their effect was studied on in vitro models of normal or hpv-transformed epithelial cell cul ... | 1996 | 8615618 |
| re: the detection of human papillomavirus deoxyribonucleic acid in intraepithelial, in situ, verrucous and invasive carcinoma of the penis. | 1996 | 8618323 | |
| cell cycle regulation of nuclear factor p32 dna-binding activity by novel phase-specific inhibitors. | the nuclear factor p92, originally discovered by its interaction with the human papillomavirus type 18 enhancer, is a cellular protein whose activity is restricted to s phase in human primary fibroblasts. the human papillomavirus type 18 p92 binding sequence confers enhancer activity on a heterologous promoter, suggesting that p92 acts as a transcription factor. we have identified a class of nuclear inhibitory proteins, i-92s, which noncovalently associate with p92 but not with other transcripti ... | 1996 | 8621580 |
| domains of the e1 protein of human papillomavirus type 33 involved in binding to the e2 protein. | papillomavirus e1 and e2 proteins are essential for the initiation of viral dna replication. we have now analyzed the interaction of e1 and e2 of human papillomavirus type 33, which is associated with cervical carcinoma. when synthesized in insect cells using the baculovirus expression system, the e1 and e2 proteins interacted efficiently at 4 degree. a monoclonal antibody recognizing e1 amino acids 584--600 inhibited the binding of e2 and vice versa, indicating that these amino acids are involv ... | 1996 | 8623535 |
| tumor necrosis factor alpha interferes with the cell cycle of normal and papillomavirus-immortalized human keratinocytes. | we have shown that normal and human papillomavirus (hpv) type 16 immortalized human foreskin keratinocytes are growth inhibited by tumor necrosis factor alpha (tnf-alpha), whereas hpv-18- and sv40-immortalized keratinocytes are resistant to this cytokine (1). in this report, we investigated the expression of mitotic regulatory proteins, such as cyclin a, cyclin b, and p34cdc2. after exposure to tnf-alpha, normal and hpv-16-immortalized cells exhibited a dramatic decrease in the expression of the ... | 1996 | 8625327 |
| human papillomavirus detection of endometrioid carcinoma with squamous differentiation of the uterine corpus. | many studies have shown a link between human papillomavirus (hpv) and cervical carcinoma. however, studies on the association of hpv with endometrioid carcinoma of the corpus uteri are sparse and controversial. in this study, 33 formalin-fixed, paraffin-embedded tissue samples of endometrioid carcinoma with squamous cell differentiation in grade 1 (adenoacanthoma) and 10 additional samples of endometrioid carcinoma with less squamous cell differentiation in grade 2 or 3 (adenosquamous carcinoma) ... | 1996 | 8626134 |
| targeted mutagenesis of the human papillomavirus type 16 e2 transactivation domain reveals separable transcriptional activation and dna replication functions. | the e2 gene products of papillomavirus play key roles in viral replication, both as regulators of viral transcription and as auxiliary factors that act with e1 in viral dna replication. we have carried out a detailed structure-function analysis of conserved amino acids within the n-terminal domain of the human papillomavirus type 16 (hpv16) e2 protein. these mutants were tested for their transcriptional activation activities as well as transient dna replication and e1 binding activities. analysi ... | 1996 | 8627680 |
| intratype variation in 12 human papillomavirus types: a worldwide perspective. | in this study, we have examined intratype human papillomavirus (hpv) sequence variation in a worldwide collection of cervical specimens. twelve different hpv types including hpv-18, hpv-33, hpv-35, hpv-39, hpv-45, hpv-51, hpv-52, hpv-58, hpv-59, hpv-68 (me180), mm9/pap238a (recently designated hpv-73), and a novel partial genomic hpv sequence designated mm4/wl3b were analyzed in this study. cervical specimens were collected as part of epidemiological investigations conducted in new mexico and an ... | 1996 | 8627792 |
| persistence of human papillomavirus (hpv) infections preceding cervical carcinoma. | a persistent genital infection with an oncogene-type of human papillomavirus (hpv) is considered to be essential for the development of most cervical carcinomas. therefore, hpv analysis has been proposed as a possible complementary cytological screening program. the authors have developed a technique to analyze archival pap smears, which has enabled them to study the relation between persistent hpv infection and the development of cervical cancer. | 1996 | 8630917 |
| both cell proliferation and apoptosis increase with lesion grade in cervical neoplasia but do not correlate with human papillomavirus type. | recent molecular studies suggest that the expression of high-risk but not low-risk human papillomavirus (hpv) oncoproteins e6 and e7 can significantly alter normal cell cycle regulation. the alterations in cell cycle regulation may be reflected by changes in the balance between cell growth and cell loss through apoptosis in cell populations expressing e6 and/or e7. we evaluated the kinetic indices of cell proliferation and apoptosis in a histopathological spectrum of cervical neoplasia and compa ... | 1996 | 8630992 |
| identification of two novel cellular genes associated with multistage carcinogenesis of human endocervical cells by mrna differential display. | carcinogenesis originating from cervical cells has been recognized as a multistage process in which human papillomavirus (hpv) infection and cofactors, such as cigarette smoke, are frequently involved in the development of malignant cancer. however, the molecular mechanism underlying this process remains poorly understood. to identify the cellular genes involved in multistage cervical oncogenesis, we used the mrna differential display method to analyze primary human endocervical cells (hen), hpv ... | 1996 | 8631146 |
| specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant. | the p53 tumor-suppressor gene product is frequently inactivated in malignancies by point mutation. although most tumor-derived p53 mutants show loss of sequence specific transcriptional activation, some mutants have been identified which retain this activity. one such mutant, p53175p, is defective for the suppression of transformation in rodent cells, despite retaining the ability to suppress the growth of p53-null human cells. we now demonstrate that p53175p can induce a cell-cycle arrest in ap ... | 1996 | 8631304 |
| human papillomavirus infection in hong kong chinese women with normal and abnormal cervix--detection by polymerase chain reaction method on cervical scrapes. | detection of human papillomavirus (hpv) was accomplished by utilizing polymerase chain reaction methods on cervical scrapes from a total of 488 hong kong chinese women attending the colposcopy, general, and antenatal clinics. from colposcopy clinic, 10% of normal cervix, 31% of condyloma, 56, 50, and 57% of cin i, cin ii, and cin iii, respectively, and 88% of squamous cell carcinoma contain hpv. the overall detection rate is 30%. the most prevalent type is 16. four percent of scrapes from normal ... | 1996 | 8631541 |
| activation of the endogenous p53 growth inhibitory pathway in hela cervical carcinoma cells by expression of the bovine papillomavirus e2 gene. | we previously showed that expression of the bovine papillomavirus (bpv) e2 gene results in a dramatic inhibition of the proliferation of several human cervical carcinoma cell lines, including hela cells which contain human papillomavirus (hpv) type 18 dna. we have assessed the status of endogenous g1 cell cycle regulatory proteins, including the tumor suppressor proteins, p53 and p105rb, in order to investigate growth regulatory pathways in hela cells following e2 expression. the p53 tumor suppr ... | 1996 | 8632901 |
| second primary cancers after vulvar and vaginal cancers. | our objective was to examine the occurrence of second primary cancers after vaginal and vulvar cancers. | 1996 | 8633671 |
| type 73 human papillomavirus in esophageal squamous cell carcinoma: a novel association. | human papillomaviruses (hpvs) commonly cause proliferative lesions of squamous epithelia, and infection with certain hpv types carries a high risk of malignant transformation, especially in the uterine cervix but also at other sites, including the esophagus. we used molecular techniques to detect and type hpv in an in situ squamous cell carcinoma in the esophagus of a 39-year old woman. | 1996 | 8640690 |
| influence of human papillomavirus type 16 gene expression on in vitro differentiation of the human teratocarcinoma cell line 2102ep. | human papillomaviruses (hpvs) are known to infect human keratinocytes and cause alterations in epithelial differentiation. we showed in this study that expression of the hpv-16 genome was able to interfere with the in vitro differentiation of a human simple-epithelial cell type, the 2102ep teratocarcinoma cell line. stable hpv-16 genome-expressing 2102ep cell lines were generated, and subsequent alterations in differentiation were analyzed in comparison with parental 2102ep cells. we found that ... | 1996 | 8645425 |
| specific transformation abolishes cyclin d1 fluctuation throughout the cell cycle. | we analysed cyclin d1 mrna and protein expression in several different cell types after separating these cells according to their different cell cycle phases by centrifugal elutriation. in normal human and rat fibroblasts cyclin d1 expression is high in early to mid g1 and decreases about 6-7 fold before onset of replication. it has been demonstrated that specific transforming events, such as loss of functional retinoblastoma protein, overexpression of c-myc, and transfection with the human papi ... | 1996 | 8647239 |
| identification of nuclear and cytoplasmic proteins that interact specifically with an au-rich, cis-acting inhibitory sequence in the 3' untranslated region of human papillomavirus type 1 late mrnas. | expression of human papillomavirus late genes encoding l1 and l2 capsid proteins is restricted to terminally differentiated epithelial cells. we have previously identified and characterized an au-rich, cis-acting negative regulatory element in the 3' untranslated region of human papillomavirus type 1 late mrnas. this element acts posttranscriptionally to reduce mrna levels and the translation efficiency of mrnas. the experiments reported here are a continuation of our previous work. we have used ... | 1996 | 8648700 |
| bilateral primary ovarian squamous cell carcinoma associated with human papilloma virus infection and vulvar and cervical intraepithelial neoplasia. a case report with review of the literature. | primary squamous cell carcinoma of the ovary is rare. most cases represent malignant transformation of ovarian teratomas. other cases are associated with preexisting brenner tumor or ovarian endometriosis. we report a primary ovarian squamous cell carcinoma in a 40-year-old woman. the patient had recurrent high-grade intraepithelial neoplasia of the vulva (vin) and recurrent high-grade cervical intraepithelial neoplasia (cin). human papilloma virus (hpv) dna 16/18 was identified in an in situ an ... | 1996 | 8651358 |
| in vivo ubiquitination and proteasome-mediated degradation of p53(1). | the levels of the tumor suppressor protein p53 are generally quite low in normal cells, due in part to its rapid turnover. previous studies have implicated ubiquitin-dependent proteolysis in the turnover of wild-type p53 but have not established whether or not p53 is itself a substrate of the ubiquitin system. in this study, inhibitors of the 26s proteasome have been used to further explore the role of ubiquitin proteolysis in regulating p53 turnover. increased levels of the tumor suppressor pro ... | 1996 | 8653711 |
| serology of human papillomavirus type 16 infections: where angels fear to tread? | 1996 | 8656004 | |
| transforming activity of the e6 gene of hpv-11gt in nih 3t3 and ref 52 cells: correlation with the level of e6 transcription. | among human papillomavirus (hpv) types, clinical association with benign vs malignant lesions correlates with the ability of the corresponding oncogenes to transform cells in vitro. however, even though hpv-11 is considered a low-risk type, we have reported previously that the e5a oncogene of hpv-11gt is capable of transforming nih 3t3 cells in culture. in this study, we found that hpv-11gt e5a and e6 oncogenes have the ability to transform nih 3t3 and the rat embryo fibroblast line ref 52. cell ... | 1996 | 8659100 |
| ucn-01: a potent abrogator of g2 checkpoint function in cancer cells with disrupted p53. | arrest of the cell cycle in g2 phase following dna damage helps protect cell viability by allowing time for dna repair before entry into mitosis (m phase). abrogation of g2 arrest sensitizes cells to the effects of dna-damaging agents. ucn-01 (7-hydroxystaurosporine), a protein kinase c inhibitor that may block g2 checkpoint regulation, has been reported to enhance the cytotoxicity of mitomycin c, a known dna-damaging agent. | 1996 | 8667426 |
| characterization of a human ubiquitin-conjugating enzyme gene ube2l3. | ubiquitin-conjugating enzymes (e2s) are essential components of the post-translational protein ubiquitination pathway, mediating the transfer of activated ubiquitin to substrate proteins. we have identified a human gene, ube2l3, localized on chromosome (chr) 22q11. 2-13.1, encoding an e2 almost identical to that encoded by the recently described human l-ubc (ube2l1) gene present on chr 14q24.3. using chromosome-specific vectorette pcr, we have determined the intron/exon structure of ube2l3. in c ... | 1996 | 8672131 |
| mutant p53-induced immortalization of primary human mammary epithelial cells. | mutations of the p53 gene are the most frequent genetic lesions in breast cancer, suggesting a critical role for p53 protein in normal mammary cell growth control. indeed, the p53-targeting human papillomavirus oncogene e6 induces efficient immortalization of normal human mammary epithelial cells (mecs). to assess whether selective loss of p53 is sufficient for mec immortalization, we introduced seven missense mutants and one single-amino acid deletion mutant (del239) of p53 into the 76n normal ... | 1996 | 8674072 |
| comparison of 35s and chemiluminescence for hpv in situ hybridization in carcinoma cell lines and on human cervical intraepithelial neoplasia. | for in situ hybridization (ish), development of sensitive, nontoxic alternatives to the use of radioactivity is a constant concern. in this trend, and close to chromogenes and fluorophores, chemiluminescence appears an attractive method. a first positive experience in immunocytochemistry and in ish, by using the enhanced luminol as luminogene substrate for horseradish peroxidase (hrp) led us to compare the sensitivity of 35s autoradiography and chemiluminescence. for this purpose, we used three ... | 1996 | 8675987 |
| high-risk human papillomavirus e6 protein has two distinct binding sites within p53, of which only one determines degradation. | human papillomavirus (hpv) e6 protein can inactivate tumor suppressor p53 by inducing its degradation. we now find that high-risk hpv e6 binds to p53 at two distinct sites; one is within the core structure of p53, and another is at the c terminus of p53. binding to the core of p53 is required for e6-mediated degradation, as shown by deletion analysis and the properties of a point mutant at residue 135. both low- and high-risk hpv e6 can bind to a c-terminal region of p53, but these interactions ... | 1996 | 8676476 |
| c/ebpbeta is a negative regulator of human papillomavirus type 11 in keratinocytes. | we have evaluated the impact of the ccaat enhancer-binding protein (c/ebp) transcription factors on human papillomavirus type 11 (hpv11). c/ebpbeta is in nuclei of cultured foreskin keratinocytes and binds its consensus sequence in hpv11 dna. we have used the novel approach of depleting the availability of c/ebps in vivo using nuclease-resistant oligomers containing c/ebp dna binding sites. in cultured foreskin keratinocytes containing replicating hpv11 dna, levels of both hpv11 transcripts and ... | 1996 | 8676519 |
| human papillomavirus in nonmelanoma skin cancer? the phylogenetic tree of the papillomavirus family is not yet complete. | 1996 | 8678583 | |
| the regulation mechanism of c-jun and junb by human papillomavirus type 16 e5 oncoprotein. | in this study, we show that hpv-16 e5 induced anchorage-independent growth in immortalized human epidermal keratinocytes and that hpv-16 e5 in human keratinocytes had higher expression of c-jun and junb; also, we investigated the role of transcriptional initiation pathways in the expression elevation. in addition, ras-dependent pathway, as well as pkc-dependent pathway, leads to hpv-16 e5-induced c-jun gene expression. | 1996 | 8678826 |
| papillomavirus oncoproteins as vaccine candidates. | 1996 | 8684094 | |
| increase of genital human papillomavirus infection among men and women in croatia. | the presence of genital human papillomavirus (hpv) among men and women in croatia was investigated from 1990 to 1993. dna obtained from 338 cervical and 79 male urethral scrapes was analysed by slot-blot hybridization with digoxigenin labeled hpv type 6, 11, 16 and 18 dna probes. the prevalence of hpv infection was higher in the male population (26.6%) than in the female population (19.8%). low risk hpv (hpv 6, 11), high risk hpv (hpv 16, 18) and indeterminate hpv were found in 5.3%, 6.9% and 8. ... | 1996 | 8687096 |
| efficacy of the association of 13-cis-retinoic acid (13cra) and alpha-interferon 2a (alpha-ifn 2a) in moderate-severe cervical intraepithelial neoplasia (cin ii-iii): a pilot study. | recent in vitro studies have suggested a possible therapeutic synergism between alpha-ifn 2a and 13cra in certain neoplasias, while encouraging in vivo findings strongly support the enhanced effectiveness of the two agents when used in combination. the specific aim of our study was to evaluate the efficacy and the toxicity of the association of 13cra and alpha-ifn 2a in patients with cin ii and cin iii who refused surgical treatment. twenty-one patients (aged between 25 and 58 years), of which 1 ... | 1996 | 8687154 |
| applications of the monitoring process model to coping with severe long-term medical threats. | guided by the monitoring process model (mpm), the authors explored the illness responses of 2 samples: high monitors (who are cognitively vigilant to and amplify threat-related cues) and low monitors (who avoid them and blunt their impact). both samples-101 women with human papillomavirus-related precancerous cervical dysplasia and 75 hiv-infected gay men-were undergoing long-term medical follow-up and management. structural equation analysis showed an adequate fit of the mpm to the data within ... | 1996 | 8698036 |
| factors influencing tumor cell kinetics in cervical cancer. | fresh tumor tissues instead of paraffin-embedded sections were used to study the clinical significance of the tumor cell kinetics in cervical carcinomas by flow cytometry. we analyzed specimens from 153 women with cervical cancer, and dna aneuploidy was found in 61 cases (39.9%). the mean age of patients with aneuploid tumors was significantly higher than the age of patients with diploid tumors (p < 0.001). the mean proliferation index for aneuploid tumors was significantly higher than those for ... | 1996 | 8698752 |
| abrogation of p53-induced g1 arrest by the hpv 16 e7 protein does not inhibit p53-induced apoptosis. | wild type (wt) p53 expressed from a temperature-sensitive construct (ts p53) can induce both g1 cell cycle arrest and apoptosis in the p53-negative j3d mouse t lymphoma line (wang et al, 1995). the human papillomavirus (hpv) 16 e7 protein has been shown to prevent p53-induced g1 cell cycle arrest following dna damage. we asked whether inhibition of p53-induced g1 arrest by overexpression of the hpv16 e7 protein in the ts p53-transfected j3d cells would interfere with p53-induced apoptosis. where ... | 1996 | 8700534 |
| [anus cancer]. | the pathology, etiology and epidemiology of anal cancer (ca) and the treatment and prognostic factors are reviewed. ca is a rare disease. however, the incidence is rising and is now 0.7 per 100,000 women and 0.4 per 100,000 men in denmark. the median age is 60 years. smoking and infection with human papillomavirus or hiv increases the risk of ca. the most important prognostic factors are tumour size, depth of invasion, inquinal lymph node involvement, differentiation and dna ploidy. previously c ... | 1996 | 8701522 |
| therapeutic potential of cidofovir (hpmpc, vistide) for the treatment of dna virus (i.e. herpes-, papova-, pox- and adenovirus) infections. | (s)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (hpmpc, cidofovir, vistide) is an acyclic nucleoside phosphonate with broad-spectrum activity against a wide variety of dna viruses including herpesviruses [herpes simplex virus type 1 (hsv-1) and type 2 (hsv-2), varicella-zoster virus (vzv), cytomegalovirus (cmv), epstein-barr virus (ebv), human herpesvirus type 6 (hhv-6) and equine and bovine herpesviruses], papovaviruses [human polyoma virus and human papilloma virus (hpv)], adeno-, irido-, ... | 1996 | 8701600 |
| human papillomavirus types 16 and 18 infection in infiltrating adenocarcinoma of the cervix: pcr analysis of 138 cases and correlation with histologic type and grade. | the authors investigated by pcr 138 infiltrating cervical adenocarcinoma (27 grade 1, 76 grade 2, and 35 grade 3) for the presence of human papillomavirus (hpv) 16 and 18 infection. they included 95 (68.8%) mucinous and 43(31.2%) non-mucinous tumors. the overall prevalence of hpv infection was 84.8%; 28.3% of the cases were positive for hpv 16, 29.7% for hpv 18, and 26.8% for both hpvs. amplification of hpv 16 and 18 negative cases with consensus primers my09/my11 failed to yield any additional ... | 1996 | 8701932 |
| cloning of mucosal and cutaneous hpv sequences in a metastatic squamous cell carcinoma from an epidermodysplasia verruciformis patient. | human papillomavirus (hpv) is a dna tumor virus strongly associated with cervical neoplasias. there are over 80 different types of hpvs which can infect either mucosal or cutaneous tissue. cutaneous squamous cell carcinomas (scc) associated with hpv are often seen in patients with epidermodysplasia verruciformis (ev). ev is characterized by cutaneous lesions that progress to scc upon uv exposure. in characterizing the hpv types associated with an unusually aggressive form of ev, we have cloned a ... | 1996 | 8702229 |
| [human papillomavirus (hpv) infection in sexual partners of women with condylomatous cervical dysplasia]. | human papillomavirus (hpv) genital infection is a sexually transmitted disease that appears to be involved in the pathogenesis of various tumors of the genitourinary system, especially carcinoma of the uterine cervix. diagnosis and treatment of sexual partners of female carriers is fundamental in preventing reinfection after treatment. | 1996 | 8702320 |
| human papillomavirus in cyclophosphamide and diverticulum-associated squamous cell carcinoma of urinary bladder: a case report. | the association of cyclophosphamide therapy with the development of urothelial malignancy has been documented. bladder diverticula associated with squamous cell carcinoma were also identified. in addition, incorporation of human papillomavirus (hpv) deoxyribonucleic acid (dna) has been previously shown in urothelial carcinoma by in situ hybridization technique. here a case is reported of bladder squamous cell carcinoma occurring four years after intravenous pulse therapy with cyclophosphamide in ... | 1996 | 8705886 |
| the human papillomavirus e6/e7 genes induce discordant changes in the expression of cell growth regulatory proteins. | the e6/e7 oncoproteins of human papillomavirus (hpv) types 16 and 18 are responsible for the efficient immortalization of human genital keratinocytes and we have recently reported that such immortalized cells display alterations in the expression of cyclin a, cyclin b, and cdc-2. to determine whether these alterations were the consequence of e6/e7 protein expression or whether they resulted from the process of cellular immortalization, we multiply-infected primary genital keratinocytes with a re ... | 1996 | 8706240 |
| expression of hpv16 e6 or e7 increases integration of foreign dna. | in most invasive cervical carcinomas, high-risk human papillomavirus (hpv) dna is integrated into the host genome, while in pre-invasive cervical lesions the viral genome is typically maintained exclusively as an episome. in contrast, integration of low-risk hpv dna is rare, as is the association of low-risk hpvs with carcinomas. high-risk hpv integration is associated with a selective growth advantage of affected cells, and hence, integration is likely to be an important genetic alteration cont ... | 1996 | 8710383 |
| differential effects of progestins and estrogens on long control regions of human papillomavirus types 16 and 18. | we have studied effects of a series of progestins and estrogens on regulation of human papillomavirus (hpv) types 16 and 18 gene expression via long control region (lcr), using a transient expression assay which represented the episomal state of hpvs in precancerous lesions. results showed that hpv gene expression induced by these steroid analogs were diverse. gene expression via hpv16-lcr was upregulated 2-3 fold under treatment with 10(-7) m estriol, 17 beta-estradiol, and several progestins i ... | 1996 | 8713103 |
| oral contraceptives and cancer. a review of the evidence. | the following review considers epidemiological data published from 1990 onwards on oral contraceptives (ocs) and the risk of cancers of the breast, cervix uteri, endometrium, ovary, liver and skin. in several studies, breast cancer risk was seen to be elevated among women who were current users of an oc, or had recently stopped using an oc, whereas there was no residual risk 5 or more years after stopping oc use. no interaction was observed between type of oc, or with any recognised risk factor ... | 1996 | 8713694 |
| prevalence of mucosotropic human papillomaviruses in squamous-cell carcinoma of the head and neck. | the prevalence of mucosotropic human papillomavirus (hpv) dna in 63 squamous-cell carcinomas (scc) from different anatomic sites in the head and neck was determined by general primer-mediated polymerase chain reaction (gp-pcr). hpv dna was detected in 20.6% of scc. additional type-specific pcr for hpv 6, 11, 16, 18, 31 and 33 demonstrated the presence of hpv 16 alone in these carcinomas. hpv 16 was also detected in normal epithelium from the resection margins of the majority of hpv-positive scc. ... | 1996 | 8635861 |
| human papillomavirus infections in nonmelanoma skin cancers from renal transplant recipients and nonimmunosuppressed patients. | nonmelanoma carcinomas of the skin represent the most frequent cancers among the caucasian population worldwide. they occur with high frequency in renal allograft recipient patients after prolonged immunosuppression. | 1996 | 8637046 |
| human papillomavirus dna in invasive cervical carcinomas and its association with patient survival: a nested case-control study. | this study sought to examine the association between the presence of human papillomavirus (hpv) dna in invasive cervical cancer and prognosis. a case-control study was undertaken nested in a cohort of 208 patients with invasive cervical carcinoma in montreal. all 40 deceased patients formed the case groups. a control group of equal size was selected by matching to each case (1:1) a patient of the same age and year of admission who had survived her disease. hpv dna was detected by the use of a pc ... | 1996 | 8722218 |
| vulvar squamous cell carcinoma. | squamous cell carcinoma of the vulva is a rare disease, mainly seen in elderly women. risk factors are advanced age, an immunocompromised status, longstanding vulvar dystrophy, vin, a history of vulvar human papillomavirus infection, and a history of cervical cancer. vulvar cancer should be considered as a skin tumor and detection is possible in an early stage. however, because of patients' and doctors' delay, one in three vulvar cancers is not treated before an advanced stage. the tumor metasta ... | 1996 | 8723825 |
| [a case of conjunctival raspberry tumor of viral origin]. | we describe the clinical and histopathological findings of a conjunctival papilloma due to papillomavirus. the therapeutic method applied was excision plus cryotherapy. these lesions are known to recur, and papillomavirus dna sequences are present in several cases of conjunctival dysplasia and carcinoma. using biological molecular methods (in situ hybridization, southern blot hybridization, and particularly polymerase chain reaction), more than 60 human papillomavirus have currently been reporte ... | 1996 | 8731783 |
| herpes simplex virus infection masquerading as condyloma acuminata in a patient with hiv disease. | verrucous lesions in patients with human immunodeficiency virus (hiv) disease may be caused by viruses other than the human papillomavirus. we describe a 32-year-old hiv-positive black man who presented with a verrucous lesion of the intergluteal cleft that clinically resembled condyloma acuminata or verrucous carcinoma. histopathological examination revealed the changes of herpes virus infection, and culture of the tissue confirmed the presence of herpes simplex virus. human papillomavirus was ... | 1996 | 8733396 |
| college health providers' knowledge, attitudes, and management practices of genital hpv infection. | this comparative survey of college health providers explored nurse practitioners' (n = 73) and physicians' (n = 70) knowledge, attitudes, and management practices related to genital human papillomavirus (hpv) infection in females. both groups had adequate knowledge of basic issues of hpv epidemiology, diagnosis, and treatment. divergent attitudes and management practices were reported among the providers, with generally low agreement with national std treatment guidelines published by the center ... | 1996 | 8734630 |