Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| [synthesis of quinoline-3- and quinoxaline-2- derivatives and their actions against various malarial parasites]. | 1976 | 799316 | |
| the effects of azadiracta indica in acute plasmodium berghei malaria [proceedings]. | 1976 | 799404 | |
| non-antibody factor(s) in adult serum decreases the infectivity of plasmodium berghei. | 1976 | 320729 | |
| from sharks to coenzyme q10. | 1976 | 187031 | |
| serum-soluble malarial antigens and immune complex nephritis in plasmodium berghei berghei infected mice. | swiss albino mice infected with plasmodium berghei berghi showed the serum-soluble malarial antigen and antibody on day 10 of infection onward. immune complex nephritis in these mice developed on the seventh day after inoculation. the infected kidneys revealed the deposition of mouse gamma globulin, mouse beta1c globulin and malaria antigen along the capillary wall of the glomeruli. proteinuria was detected on seventh day of infection. serum-soluble malaria antigen in probably responsible for fo ... | 1976 | 59812 |
| a review. innate resistance in malaria. | 1976 | 7463 | |
| plasmodium berghei: protection against sporozoites by normal mosquito tissue vaccination of mice. | 1976 | 9307 | |
| plasmodium berghei: sporozoite challenge, protection, and hypersensitivity in mice. | 1976 | 9308 | |
| immunity to plasmodium berghei yoelii in mice. i. the course of infection in t cell and b cell deficient mice. | the course of infection with 17x nonlethal plasmodium berghei yoelii was examined in balb/c mice which were deficient in either t cells or b cells. markedly increased parasitemia and mortality were observed in athymic (nude) mice which had been backcrossed on a balb/c background (t cell deficient) compared to similar mice which had been grafted with neonatal balb/c thymus, and were also observed in balb/c mice suppressed from birth with goat antiserum to mouse mu-chain (b cell deficient) compare ... | 1976 | 136472 |
| amodiaquin accumulation by mouse erythrocytes infected with plasmodium berghei. | 14camodiaquin accumulation by washed erythrocyte preparations was characterized to permit comparisons with chloroquine accumulation. erythrocytes infected with plasmodium berghei cs (chloroquine-susceptible) accumulate amodiaquin by a saturable process that has an apparent dissociation constant for amodiaquin of 7.6 x 10(-8) m and is competitively inhibited by chloroquine, quinine and quinacrine, as is the process of chloroquine accumulation. within experimental error, the k1 of 8 x 10(-7) m est ... | 1975 | 488 |
| refeeding-malaria and hyperferraemia. | during the central african (sahelian) drought, attacks of falciparum malaria were common in patients and their relatives shortly after their arrival in a hospital in eastern niger. a prospective study of 72 adult patients not admitted for malaria and 109 accompanying relatives was undertaken to investigate this observation. 23 attacks occurred in patients and 51 in relatives, with a peak frequency five days after arrival. on arrival, parasitaemia was low but reached a maximum by five days. s ... | 1975 | 47080 |
| enhanced cytotoxicity in mice of combinations of concanavalin a and selected antitumor drugs. | concanavalin a (con a) injected intraperitoneally at a dose of 50 mg per kg was not lethal for male balb/c mice. six hours after administration of 5 mg con a/kg, the proportioy 24 hr, the proportion of granulocytes had decreased to 56%. adiministration of 5 mg con a/kg 24 hr before 200 mg of 5[3,3-bis(2-chloroethyl)-triazeno]-imidazole-4-carboxamide per kg, or 100 mg of 5-fluorouracil per kg resulted in a significant enhancement of lethality. simulatenous administration of 5 mg con a/gm and 10 m ... | 1975 | 168746 |
| malaria studies in vitro. iv: chloroquine resistance and the intracellular ph of erythrocytes parasitised with plasmodium berghei. | the erythrocytic stages of strains of plasmodia sensitive to chloroquine (cq) concentrate some three to six times more drug than cq-resistant strains. a simple, but so far untested hypothesis is that the intracellular ph of drug resistant strains is higher than that for sensitive strains. this would result in a reduced accumulation of any weakly basic drug molecule (e.g. cq) which is capable of passive diffusion through the cellular membran. the mean intracellular ph of erythrocytes parasitised ... | 1975 | 239645 |
| biological screening in the u.s. army antimalarial drug development program. | the methods of testing drugs in the united states army antimalarial drug development program are described. to date over two hundred thousand compounds have been screened. for each 3,000 compounds evaluated in the primary screen, only 1 is assessed for efficacy in the final test system. of those potential antimalarials assessed in this last system, only about half are deemed worthy of preclinical toxicological evaluation. | 1975 | 804264 |
| pyruvate kinase in malaria host-parasite interaction. | 1975 | 805379 | |
| orally-administered silver sulfadiazine: chemotherapy and toxicology in cf-1 mice; plasmodium berghei (malaria) and pseudomonas aeruginosa. | silver sulfadiazine when administered orally and subcutaneously to cf-1 mice in doses not exceeding 1,050 mg/kg proved to have minimal toxicity. no pathology or abnormal reactions were seen in cf-1 mice after receiving 1,050 mg/kg orally and subcutaneously once a day for 30 days. silver sulfadiazine in doses of 1,050 mg/kg, once a day for 5 days cured mice of plasmodium berghei even after splenectomy. parasitemia was reduced to zero in 1-3 days and antimalarial activity was not inhibited signifi ... | 1975 | 807459 |
| amino acid analogs. iii: new syntheses of monomethyl- and monophenylglutamic acids. | glutamic acid analogs containing 3- and 4-methyl and 2-, 3-, and 4-phenyl substituents were prepared. the 3- and 4-methyl- and 3- and 4-phenylglutamic acids did not inhibit plasmodium berghei and were nontoxic to the host (mice) at 640 mg/kg. the five analogs in addition to 2-methlglutamic acid were inactive against lactobacillus casei at 1000 mug/ml in a defined medium: against escherichia coli, only 2-methylglutamic acid caused 27% inhibition at 10,000 mug/ml. all six analogs failed to inhibit ... | 1975 | 811786 |
| quinazolines as inhibitors of dihydrofolate reductase. 3. analogs of pteroic and isopteroic acids. | a series of 19 quinazoline analogs of pteroic and isopteroic acid was prepared with particular emphasis being placed upon carboxylic acid esters. each compound was evaluated as an inhibitor of the dihydrofolate reductases from rat liver as well as from streptococcus faecium. several of the more potent inhibitors were found to be inactive against l1210 leukemia in mice at low dose levels and were lethal to mice at 100 mg/kg. six compounds were also evaluated for antimalarial activity against plas ... | 1975 | 811798 |
| the search for new antimalarial drugs. | 1975 | 813015 | |
| proceedings: the chemotherapeutic action of pam-780 against plasmodium berghei malaria in mice. | 1975 | 775791 | |
| spleen reactivity in experimental malaria of rodents. | 1975 | 776124 | |
| [behavior of a strain of p.berghei after low temperature preservation during more than 10 years]. | 1975 | 782384 | |
| proceedings: changes in pha and lps responsiveness in murine malaria. | 1975 | 766318 | |
| proceedings: the passive transfer of immunity to plasmodium berghei yoelii. | 1975 | 766319 | |
| proceedings: the t-cell response in murine malaria. | 1975 | 766320 | |
| proceedings: pharmacology of plasmodium berghei. | 1975 | 766321 | |
| the plasmodium berghei-infection in isogenic f1 (c57bl x dba)-mice. i. the course of the infection and immunization experiments. | the malarial infection caused by plasmodium berghei (strain k 173) was observed in the isogenic mouse strains c3h, c57bl, dba, and the f1 (c57bl x dba)-hybrids. in addition immunization experiments were carried out by intermittent suppression of the parasite multiplication through maintaining the infected animals on a milk diet for various length of time. the f1-hybrids were the most resistant mice and immunization was most effective in these animals, too. but if the course of the infection was ... | 1975 | 766337 |
| dynamics of thymidine incorporation by spleen cells from rats infected with plasmodium berghei. | the in vitro incorporation of thymidine by spleen cells of rat infected with plasmodium berghei was higher than that of normal rat spleen cells. the incorporation was proportional to the number of cells in the system and was related to the day of infection, e.g. spleen cells from malarious rats incorporated up to forty times as much thymidine as did normal spleen cells 21 days after inoculation. at the same time, the response of the malarious spleen cells to phytohaemagglutinin (pha) was only on ... | 1975 | 765025 |
| [increased non-specific resistance to induction of malaria by sporozoites of plasmodium berghei yoëlii in mice pretreated with a bacterial phospholipid extract]. | the injection of a bacterial phosphospholipid extract increases resistance of mice subsequently challenged with sporozoïtes of plasmodium berghei yoëlii. the pretreatment consisted of one injection of a suspension containing various amounts of phospholipid extract. it was e-fective when it shortly preceded the sporozoïtes inoculation. this resulted in total protection of a great number of animals against various amounts of sporozoïtes. there was a correlation between the dose of ebp injected and ... | 1975 | 819147 |
| chronic malarial infection in balb/c mice. effect on the immune response to sheep erythrocytes and histological changes in the liver and spleen. | chronic malarial infection was established in balb/c mice by following plasmodium berghei yoelii with p.b. berghei infection. it was found that the igg plaque-forming cell response to sheep erythrocytes was depressed for at least six months. a preliminary investigation of the histological changes in the spleen and liver is described. the possibility that chronically infected mice could serve as a model for the tropical splenomegaly syndrome is discussed. | 1975 | 779156 |
| [preparation and biological trials of antimalarial sulfa embonates]. | with the purpose of obtaining salts of sulfonamides with low toxicity but prolonged action, embonates of seven known sulfonamides, with antimalarila activity, were prepared by double exchange reaction between embonic acid and the antimalarial agents. six of the seven embonates prepared showed activity against plasmodium berghei in experimentally infected mice, one of them being significantly more active than the original sulfonamide (sulfadimethoxine). | 1975 | 788077 |
| pharmacology of the malaria parasite--a study of dose-response relationships in chloroquine-induced autophagic vacuole formation in plasmodium berghei. | 1975 | 1108883 | |
| inhibition of macromolecular synthesis in the malarial parasites by inhibitors of proteolytic enzymes. | 1975 | 1089545 | |
| motility of plasmodium berghei ookinetes in vitro. | 1975 | 1089734 | |
| plasmodium berghei: thyroid hyperplasia and thyroid hyperactivity in mice. | 1975 | 1090441 | |
| regional immunosuppression induced by plasmodium berghei yoelii infection in mice. | plasmodium berghei yoelii infection in mice severely depressed the splenic antibody response to sheep erythrocytes but had lettle effect on antibody formation in lymph nodes. | 1975 | 1090525 |
| the in vitro culture of the blood stages of plasmodium berghei. | 1975 | 1090550 | |
| humoral immunity in rodent malaria. iii: studies on the site of antibody action. | serum which protects rats against plasmodium berghei infections fails to sensitize parasitized erythrocytes in vitro for in vivo destruction. further, the efflux of 86rb from parasitized erythrocytes in the presence of complement is not accelerated. on administration to animals with preexisting malaria, it does, however, produce a relatively slow decline in parasitemia, a phenomenon interpreted in terms of the gradual production and/or release of reactive antigenic determinants associated with m ... | 1975 | 1090670 |
| development of infectivity by the plasmodium berghei sporozoite. | studies were done on the development of infectivity during ontogeny of the sporozoite of the rodent malaria parasite, plasmodium berghei. populations of sporozoites were separated from the oocysts, the hemocoel, and the salivary glands, with special precautions being taken to avoid cross-contamination between the different populations. the results indicated that populations of salivary gland sporozoites were more than 10,000 times as infective as populations of oocyst sporozoites from the same m ... | 1975 | 1090717 |
| rodent systems (plasmodium berghei-anopheles stephensi) for screening compounds for potential causal prophylaxis. | an in vivo screening system is described in which drugs administered to rats or mice and challenged with sporozoites are evaluated for their antimalarial properties (causal prophylaxis, suppression, therapy) by the presence or absence of exoerythrocytic forms and parasitemia. the system is composed of a/j mice, sprague-dawley rats, plasmodium berghei, and anopheles stephensi. good correlation has been found between test results and practical application. | 1975 | 1091166 |
| detailed purine salvage metabolism in and outside the free malarial parasite. | 1975 | 1091492 | |
| qualitative analysis of phospholipids isolated from nonviable plasmodium antigen. | 1975 | 1091493 | |
| a new prodiginne (prodigiosin-like) pigment from streptomyces. antimalarial activity of several prodiginnes. | two prodigiosin-like pigments from streptomyces sp. were shown to be undecylprodiginine (i) and butylcycloheptylprodiginine (v). the antimalarial activity of five prodiginine pigments is given. | 1975 | 1092639 |
| synthesis and antimalarial activity of heterocyclic alkyl disulfides, thiosulfates, and dithio acid derivatives. | based on the antimalarial activity in mice of bis(4-rho-acetamidobenzenesulfonamidophenyl) disulfide, a series of n-heterocyclic alkyl disulfides and thiosulfates was synthesized and screened for antimalarial activity. several related dithio acid dianions and s- blocked derivatives were also screened to provide an indication of the possible role that thiol anions might play in malaria chemotherapy. activity was limited by toxicity with these compounds, and none of those tested, with the exceptio ... | 1975 | 1092835 |
| synthesis and evaluation of 6-arylactamido-2,4-diaminoquinazolines and related compounds as folic acid antagonists. | a series of 2,4-diaminoquinazolines bearing an aryl function attached to the 6 position through an acetamido or related linkage was synthesized. each compound was evaluated as an inhibitor of rat liver dihydrofolate reductase as well as for suppressive antimalarial effects against plasmodium berghei in mice. significant in vivo activity was found to reside primarily with 5-chloro-6-arylacetamido derivatives. most of these compounds were also tested for prophylactic activity against sporozoite-in ... | 1975 | 1094114 |
| circadian and other rhythms of parasites. | 1975 | 1094812 | |
| splenic mediated erythrocyte cytotoxicity in malaria. | cell-mediated cytotoxicity in virulent rodent malaria has been demonstrated in vitro, whereby splenic cells effected specific lysis of 51cr-labelled erythrocytes from parasitized animals. more than one cellular cytolytic effector system appeared to be operative in the mouse. one effector system involved splenic macrophages, from normal or immune animals, which were increasingly cytotoxic to target cells in the presence of antibody. a second effector system involved nylonpurified immune spleen ce ... | 1975 | 1095474 |
| antimalarial compounds. xiii. new derivatives of phenyl chloromethyl sulfone. | a series of chloromethylsulfonyl derivatives of amines, biguanides and amidineureas (scheme 1) has been prepared and their antimalarial properties investigated. | 1975 | 1096101 |
| antimalarial compounds. xiv. new derivatives of 2-bromo-n,n-bis-(diethylaminoethyl)-4,5-dimethoxyanaline (rc 12). | the molecule of rc 12 which was found previously to exhibit antimalarial activity has been modified, by replacing groups in positions 1 and 2 by nhar, s-ar, no2, sulfonamido and other substituents. the new derivatives (table 1) were tested for toxicity and antimalarial activity agains plasmodium berghei in mice (table 2). | 1975 | 1096102 |
| cerebral malaria in a virulent rodent plasmodial infection. | 1975 | 1096377 | |
| anaemia in mice with concomitant schistosoma mansoni and plasmodium berghei yoelii infection. | 1. the effect on anaemia in mice given plasmodium berghei yoelii 3 and 5 weeks after exposure to schistosoma mansoni cercariae, was investigated. 2. haematological criteria (pcv and haemoglobin levels), reticulocytosis, parasitaemia and splenomegaly were used as indices. 3. anaemia was severe in the animals given p. b. yoelii and in those with mixed infection (p. b: yoelii plus s. mansoni). malaria was found to dominate the picture until the clearance of the parasitaemia. the effect of the inter ... | 1975 | 1096378 |
| counter-current immunoelectrophoresis for the demonstration of malarial antigens and antibodies in the sera of rats and mice. | 1975 | 1096380 | |
| plasmodium berghei: immunologic enhancement of antigen by adjuvant addition. | 1975 | 1097263 | |
| antibody-mediated elimination of malaria parasites (plasmodium berghei) in vivo. | an infective preparation of extracellular blood forms (fp) of plasmodium berghei was used to study some aspects of the interaction between protective antibodies and malaria parasites. fp but not infected erythrocytes (irbc) were shown by the fluorescent antibody technique to be coated by antibodies after in vitro incubation with immune serum. preincubation of both fp and irbc with immune serum followed by their washing did not result in enhanced elimination of the parasites in vivo. however, fp ... | 1975 | 1097338 |
| synthesis of (4-quinolinoamino)aminoalkyltetrahydronaphthalene derivatives for possible antimalarial activity. | (4-quinolinoamino)aminoalkyltetrahydronaphthalene derivatives were synthesized in an attempt to introduce new agents with antimalarial activity. | 1975 | 1097633 |
| potential antimalarials. 9. resolution of alpha-diheptylaminomethyl-6-bromo-9-phenanthrenemethanol by an unusual method. | 1975 | 1097687 | |
| quinoxaline studies. 23. potential antimalarials. substituted 5,8-dimethoxyquinoxalines. | two series of 2,3-disubstituted 5,8-dimethoxy-6-[n- (omega-dimethylaminoalkyl) amino] quinoxalines were prepared: the first series with identical 2,3-substituents h, ch3, c6h5, c6h4-4-cl, and ch2c6h5; and the second with identical styryl groups ch=chc6h5, ch=chc6h4-4-cl, ch=chc6h3-3,4-c12, ch=chc6h4-4-f, ch=chc6h4-4-cf3, and ch=chc6h4-4-no2. none of the substances possessed antimalarial activity; several were toxic at highest dosage levels. | 1975 | 1097693 |
| the chemotherapy of rodent malaria, xxi. action of quinine and wr 122 (a 9-phenanthrenemethanol) on the fine structure of plasmodium berghei in mouse blood. | the effects of quinine and a 9-phenanthrenemethanol, wr 122,455 on the fine structure of plasmodium berghei have been investigated. changes consequent upon quinine treatment were noted in the outer membranes (including those that surround the "food vacuole") and the digestive vacuoles. these changes were followed by cytoplasmic degeneration and vacuolization. wr 122,455 caused morphological changes in at least three areas of the parasite, (1) the outer membranes, (2) the digestive vacuole and (3 ... | 1975 | 1098583 |
| the chemotherapy of rodent malaria, xxii. the value of drug-resistant strains of p. berghei in screening for blood schizontocidal activity. | data are provided on the activity of a variety of antimalarial drugs against drug-sensitive and drug-resistant lines of plasmodium berghei in albino mice. parallel data for the response of the drug-sensitive parasites to these compounds in vitro indicate whether the drugs have a chloroquine-like or quinine-like type of action, or neither. the value of this test system for drug evaluation is debated. it is concluded that the in vivo tests do provide a valuable indication of the potential use of a ... | 1975 | 1098584 |
| sudden increase in virulence in a strain of plasmodium berghei yoelii. | the mild and chronic 17x strain of plasmodium berghei yoelii showed a sudden increase in virulence following a period of 110 days in the deep freeze. the enhanced virulence was seen in a very high and early parasite peak in the blood and a 100% mortality of all infected mice. the exalted virulence remained unaltered following a number of blood transfers of the strain and after four cyclical transmissions through anopheles stephensi. enzyme pattern studies revealed that the virulent strain posses ... | 1975 | 1098585 |
| role of complement components in the susceptibility to plasmodium berghei infection among inbred strains of mice. | inbred strains of mice, sensitive and resistant to plasmodium berghei infections, including a complement deficient strain were infected with p. berghei. daily levels of parasitaemia were determined and serum levels of complement components (c3 and c5) measured by standard haemolytic assay. serum levels of c3 and c5 were depressed in all strains of mice infected with p. berghei. there was no difference in the infectivity and course of p. berghei infection in the co-isogenic c5 deficient and non-d ... | 1975 | 1098586 |
| purification and some properties of malarial pigment. | malarial pigment from erythrocytes infected with plasmodium berghei was purified by treatment with sodium dodecyl sulphate solution, followed by incubation with pancreatin. the purified pigment retained the apparently crystalline form of pigment within the parasite, rotated polarised light and had the same solubility characterisation as crude malarial pigment. it contained about 1% iron, all of which could be accounted for in terms of haemin. the iron of the pigment molecule is oxidised by the p ... | 1975 | 1098588 |
| immunological studies in rodent malaria. i: protective immunity induced in mice by mild strains of plasmodium berghei yoelii against a virulent and fatal line of this plasmodium. | mild and virulent lines of plasmodium berghei yoelii are readily distinguished both by their course of infection and by the preference of the virulent line for mature red blood cells. mice given either mild line were fully protected against the virulent p.b. yoelii one week after they had become negative. mice given the mild line of p.b. yoelii 17x were fully protected against a challenge by the virulent line on the third day of infection (d+3). mice given the mild and virulent lines of p.b. yoe ... | 1975 | 1098589 |
| the chemotherapy of rodent malaria, xxiii causal prophylaxis, part ii: practical experience with plasmodium yoelii nigeriensis in drug screening. | data are presented on the causal prophylactic action of about 100 compounds of various types against plasmodium yoelii nigeriensis n67 in mice. examples are given to show how action against pre-erythrocytic schizonts may be differentiated from action on emerging erythrocytic stages. in a series of 35 8-aminoquinolines, all but 10 showed definite causal prophylactic activity at tolerated doses. the data permit the compounds to be ranked in order of activity, and many are shown to be more active i ... | 1975 | 1098590 |
| a comparison of pigment from schistosoma mansoni and plasmodium berghei. | the structures of malarial and schistosomal pigment within the parasites are distinct. the two pigments are distinguishable both before and after extraction from host liver. | 1975 | 1098591 |
| antimalarials: screening of (orally administered) silver solfonamides against plasmodium berghei. | orally administered silver sulfadiazine is effective against plasmodium berghei. attempts to synthesize an active analogue with antimalarial activity failed. although several of the analogues were chemically stable (like silver sulfadiazine) in sodium chloride, none of the analogues were biologically active. this suggests that the antimalarial activity of silver sulfadiazine is stereo-specific. | 1975 | 1098869 |
| thiosemicarbazones and hydrazones of alpha-methylchalkone as potential chemotherapeutic agents. | the effectiveness of chalkones and derivatives as antibacterial and antifungal agents stimulated our interest in the possibility of coupling this type of compound with certain hydrazines and thiosemicarbazides to determine the potential chemotherapeutic activity of these combinations as anticancer and antimalarial agents. accordingly, 18 hydrazine and thiosemicarbazide derivatives of alpha-methylchalkone (dypnone) have been synthesized for study as potential antitumor agents in animal tumor syst ... | 1975 | 1099024 |
| alterations in the permeability of mouse erythrocytes infected with the malaria parasite, plasmodium berghei. | 1975 | 1099038 | |
| antimalarial phenanthrene amino alcohols. 3. halogen-containing 9-phenanthrenemethanols. | a series of new 9-phenanthrene amino alcohols has been prepared in which each compound bears from one to five halogen or halogen-containing moieties. a number of these compounds are extremely active against plasmodium berghei in the mouse. some structural requirements for optimal efficacy are considered. | 1975 | 1099200 |
| comparison of tritiated hypoxanthine, adenine and adenosine for purine-salvage incorporation into nucleic acids of the malarial parasite, plasmodium berghei. | this study was accomplished to examine the relative importance of different metabolic precursors of nucleic acid synthesis in the malarial parasite, p. berghei. three possible pathways for incorporation of adenine (type) compounds exist: 1) incorporation via hypoxanthine, 2) via adenine, or 3) via adenosine. the parasitized cell and erythrocyte-free malarial parasite were both examined because of possible metabolic differences that could be encountered. hypoxanthine was clearly the best precurso ... | 1975 | 1099747 |
| mass isolation of anopheles stephensi salivary glands infected with malarial sporozoites. | 1975 | 1100801 | |
| antimalarials. 7.2,8-bis(trifluoromethyl)-4-quinolinemethanols. | based on the high antilalarial activity of alpha-(2-piperidyl)-2,8-bis(trifluoromethyl)-4-quinolinemethanol, ten additional 2,8-bis(trifluoromethyl)-4-quinolinemethanols were prepared in which the amino alcohol side chain was structurally varied. synthesis of the compounds is described and antimalarial activity data against plasmodium berghei are presented and discussed in terms of the structure variations. | 1975 | 1100828 |
| neutralizing antibody in rodent malaria. | small numbers of rat erythrocytes infected with viable p. berghei, when inoculated into susceptible rats together with hyperimmune rat serum (his), are fully neutralized. serum from convalescent rats delays the onset of patency but does not neutralize. the neutralizing efficiency of his rises in proportion to the number of successive reinoculations of hyperimmune rats. in contrast, mice inoculated with parasites together with either his or normal rat serum succumbed to the disease at the same ti ... | 1975 | 1101458 |
| failure to protect mus musculus against plasmodium berghei with footpad injections of killed parasites incorporated in complete freund's adjuvant. | the stimulation of cell-mediated immunity by the injection of antigen from killed parasites incorporated in complete freund's adjuvant did not protect mus musculus from the erythrocytic stages of plasmodium berghei. agglutinating antibodies could not be detected, but delayed hypersensitivity was demonstrable. apparently thymocyte sensitization alone was not sufficient to afford protection. | 1975 | 1102649 |
| enhanced trypanosoma musculi infections in mice with concomitant malaria. | 1975 | 1102992 | |
| t-cell activation in murine malaria. | 1975 | 1102993 | |
| the nature of age immunity to plasmodium berghei in the rat. | the intensity of plasmodium berghei infections decreases as the age of the rat host increases. the nature of this 'age immunity' was investigated. no experimental support was found for innate resistance involving either serum non-antibody factors or changes in the erythrocytes that inhibit parasites in older rats. a cross reacting immune response active against p. berghei was not found. evidence is presented which shows that rats less than 7 weeks old lack at least part of the functional immunol ... | 1975 | 1103066 |
| [course of trypanosoma musculi infections in plasmodium berghi-infected mice (author's transl)]. | trypanosoma musculi brought into plasmodium berghei-infected mice in the later stages of the malaria infection shows rapid, approximately logarithmic multiplication in the peripheral blood. the trypanosome number increases by a factor of 2-9 per day, multiplication of the parasites kills most mice in a few days. many multiplicative forms of the trypanosomes and a few trypanosomes without nuclei are seen in blood smears. histologically and in touch preparations, masses of multiplicative forms of ... | 1975 | 1103389 |
| [altered reproductive behaviour of trypanosoma musculi after several years of passage in mice (author's transl)]. | the modified strain multiplied less in pregnant and in plasmodium berghei-infected mice, more in heavily infected normal mice, and more or less in weakly infected normal mice. the discordant behaviour in weakly infected mice was due to the occurrence in some animals of a second phase of more rapid increase of the parasitemia. this behaviour could be seen occasionally in the original strain, too. in inbred mice (balb/chan) the length of parasitemia clearly depended on inoculum size and height of ... | 1975 | 1103390 |
| effects of lowered environmental temperature on the growth of exoerythrocytic stages of plasmodium berghei. | the effect of lowered host-environmental temperature upon the development and maturation of the preerythrocytic tissue stages of rodent malaria parasites has been investigated in two strains of plasmodium berghei originating from the highlands of katanga. young albino rats inoculated with massive sporozoite doses of p. berghei nk 65 and maintained for 48 hours at 12 degrees c developed small, stunted tissue schizonts, averaging 11 x 15 microns, of a distinct morphology. control rats kept at room ... | 1975 | 1103642 |
| detection of antibody in white mice infected with plasmodium berghei by means of the indirect immunofluorescence test. | experiments have been conducted in order to test the efficacy of the immunofluorescence test in the detection of antibody in mice infected with plasmodium berghei vincke et zips, 1948. this method enables the detection of antibody in subclinical and latent cases when an occasional parasite only is present in the blood cells. of the various methods used for the preparation of antigen, and of the various fixatives, a satisfactory immunofluorescence reaction was obtained if unfixed erythrocytes wit ... | 1975 | 1104419 |
| evaluation of a method for in vitro ookinete development of the rodent malarial parasite, plasmodium berghei. | 1975 | 1104798 | |
| chloroquine resistance in malaria: variations of substrate-stimulated chloroquine accumulation. | the response of [14c]chloroquine accumulation to the provision of substrate was evaluated using washed erythrocytes infected with plasmodium berghei cs (chloroquine-susceptible), with p. berghei cr (chloroquine-resistant), with plasmodium vinckei cs, with p. vinckei cr, or with a strain of p. berghei spontaneously resistant to chloroquine, plasmodium berghei yoelii 17x. erythrocytes infected with chloroquine-resistant parasites had a blunted response, particularly to low glucose concentrations. ... | 1975 | 1104805 |
| antimalarials. synthesis and antimalarial activity of 1-(4-methoxycinnamoyl)-4-(5-phenyl-4-oxo-2-oxazolin-2-yl)piperazine and derivatives. | the preparation and activity against plasmodium berghei of derivatives of 1-(4-methoxycinnamoyl)-4-(5-phenyl-4-oxo-2-oxazolin-2-yl)piperazine are described. replacement of the cinnamoyl group was accomplished by acylation or alkylation of 1-(5-phenyl-4-oxo-2-oxazolin-2-yl)piperazine. modifications of the 5-phenyl group were prepared either by a sequence of reactions involving mandelic ester-pemoline-piperazine pemoline or by the reaction of 5-aryl-2-thio-2,4-oxazolidinedione with piperazine or n ... | 1975 | 1104830 |
| antimalarials. 3. 3-substituted 1-naphthalenemethanols. | the synthesis and antimalarial activity of 22 3-substituted 1-naphthalenemethanols whose substitution was patterned after the antimalarial 2-substituted 4-quinolinemethanols are described. the compounds were active against plasmodium berghei in mice, the most active being 6-chloro-alpha-(dibutylaminomethyl)-3-(3,4-dichlorophenyl)-1-naphthalenemethanol hydrochloride (3b). the naphthalenemethanols tested, 1b and 2b, were not photosensitizing to albino mice. structure-activity relationships between ... | 1975 | 1104831 |
| antimalarials. 10. substituted 3-halo- and 3-methoxy-2-aryl-4-quinoline(di-n-butylaminomethyl)methanols. | four 2-aryl-4-quinoline(di-n-butylaminomethyl)methanols with br, cl, f, or ome in position 3 were synthesized by modifications of standard reactions. the antimalarial activity decreased with increased size of the 3-substituent. the 3-f-4',6,8-cl3 compound was the most active (at 2.5 mg/kg) and was completely curative at 80 mg/kg against p. berghei in mice. | 1975 | 1104832 |
| intramuscular immunization of mice with irradiated plasmodium berghei sporozoites. enhancement of protection with albumin. | 1975 | 1106231 | |
| [immunosuppression in protozoan infections]. | 1975 | 1107126 | |
| antimalarial amino alcohols ii: anthraceneaminoethanols and anthraceneaminopropanols (1- and 9-substituted). | the syntheses of seven anthracene amino alcohols with one, two, or three additional substituents are described. these compounds include three 1-aminoethanols, two 9-aminoethanols, and two 9-aminopropanols, prepared from substituted anthraquinones or from 10-chloro-9-anthraldehydes. the antimalarial activity of these compounds, as well as tentative structure-activity relationships, is discussed in the light of previously published work. | 1975 | 1107515 |
| synthesis of 2-pyridyl-alpha-toluenesulfonates as antimalarials. | a series of substituted 2-pyridyl-alpha-toluenesulfonates was synthesized for antimalarial testing. they were prepared by treating various 2-pyridinols with alpha-toluenesulfonyl chlorides in the presence of an alkali. in tests against plasmodium berghei in mice at 640 mg/kg, only 3,5-dichloro-2-pyridyl-alpha-toluenesulfonate was considered active, i.e., doubled the mean survival time. | 1975 | 1107516 |
| surface properties of extracellular malaria parasites: morphological and cytochemical study. | morphological and cytochemical surface characteristics of isolated malaria parasites (plasmodium berghei) and host erythrocytes were compared by electron microscopy by using thin section and carbon replica techniques. erythrocytes were uniform in shape and had fine, granular surfaces. in contrast, free parasites exhibited a variety of sizes, shapes, and surface textures. fine surface stippling was a common topographical feature of isolated parasites. small, infective forms often had patterned su ... | 1974 | 4132619 |
| studies on the motility of plasmodium sporozoites. | 1974 | 4138523 | |
| proceedings: hydrolases of the sporogonic stage of plasmodium berghei nigeriensis. | 1974 | 4150466 | |
| 8-(omega-aminoalkylamino)quinolines as potential prophylactic antimalarials. | 1974 | 4151456 | |
| observations on the sporogonic cycle of plasmodium berghei in two australasian anophelines. | 1974 | 4152304 | |
| assessment of causal prophylactic activity in plasmodium berghei yoelii and its value for the development of new antimalarial drugs. | the causal prophylactic activity of several reference and experimental antimalarial compounds was assessed in sporozoite-induced infections of nmri mice with plasmodium berghei yoelii (strain 17x). the animals were inoculated with 10 000 sporozoites per mouse and treated once 2-4 hours later. the test system has proved to be very suitable in experiments involving more than 3 000 mice. the infection rate in 448 untreated controls was 97.3%. lowering the sporozoite content of the inoculum to 1 000 ... | 1974 | 4155355 |
| synthesis and antimalarial effects of 1-(3,4-dichlorophenyl)-3-(4-((1-ethyl-3-piperidyl)amino)-6-methyl-2-pyrimidinyl)guanidine and related substances. | 1974 | 4202215 | |
| some aspects of intracellular parasitism. | in intracellular parasitism the host cell is a true and hospitable host. the parasite does not have to break in the door. it has subtle ways of inducing the host to open the door and welcome it in. one of the exciting fields in the future of parasitology is to find out what these ways are and why they are sometimes so highly specific that the cell that invites one parasite in will not open the door to another closely related species. once inside, the parasite not only exploits nutrients already ... | 1974 | 4203157 |
| inhibition of mammalian dihydrofolate reductase by selected 2,4-diaminiquinazolines and related compounds. | 1974 | 4213189 | |
| mesoionic purinone analogs. 7. in vitro antibacterial activity of mesoionic 1,3,4-thiadiazolo(3,2-a)pyrimidine-5,7-diones. | 1974 | 4213245 |