Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| prevalence and mechanisms of β-lactam resistance in haemophilus haemolyticus. | to compare the phenotypic and genotypic β-lactam resistance profiles of non-typeable haemophilus influenzae (nthi) and the closely phylogenetically related haemophilus haemolyticus. | 2013 | 23315478 |
| predictors of viral pneumonia: the need for viral testing in all patients hospitalized for nursing home-acquired pneumonia. | community-acquired pneumonia (cap) is presumed to be bacterial in origin and empirical antibiotics are almost always given on admission. however, early detection of viral infection is also very important for hospital infection control and timely use of antiviral agents. the present study aimed to compare patients with viral and bacterial pneumonia, and identify independent predictors of viral pneumonia. | 2013 | 23441872 |
| genetic similarity between adenoid tissue and middle ear fluid isolates of streptococcus pneumoniae, haemophilus influenzae and moraxella catarrhalis from iranian children with otitis media with effusion. | otitis media with effusion (ome) is a common disease among children, in the pathogenesis of which bacterial infections play a critical role. it was suggested that adenoid tissue could serve as a reservoir for bacterial infection, the eustachian tubes being the migration routes of bacteria into the middle ear cavity. the aim of this study was to investigate the genetic similarity between isolates of streptococcus pneumoniae, haemophilus influenzae and moraxella catarrhalis, obtained from adenoid ... | 2013 | 24080321 |
| invasive haemophilus influenzae type b disease in england and wales: who is at risk after 2 decades of routine childhood vaccination? | the introduction of the haemophilus influenzae serotype b (hib) conjugate vaccine into national immunization has led to rapid and sustained declines in invasive hib disease incidence across all age groups. in industrialized countries with established hib vaccination programs, however, little is known about individuals who develop invasive hib disease. this study describes the epidemiology of invasive hib disease in england and wales during 2000-2012 and the clinical characteristics of laboratory ... | 2013 | 24076970 |
| role of intercellular adhesion molecule-1 and polymeric immunoglobulin receptor in co-colonization of airways with streptococcus pneumoniae and haemophilus influenzae. | 2013 | 24067557 | |
| novel strategies for development of next-generation glycoconjugate vaccines. | most bacterial pathogens are decorated with surface glycans called capsular polysaccharides (cpss). each cps has a unique structure that is distinctively recognized by our immune cells. these polysaccharides are important vaccine candidates given that they are located on the surface of pathogens, are easily accessible by the immune system, and often result in formation of protective antibodies. to induce cps specific adaptive immune response (i.e., t cell-mediated b cell response), cpss are conj ... | 2013 | 24066893 |
| infectious etiology of acute exacerbations in severe copd patients. | since the new gold guidelines were implemented no data have been published about the etiology of acute exacerbations (aecopd) in severe copd patients with a different frequency of annual episodes. | 2013 | 24055804 |
| [update on prevention of infections in patients without spleen or with diminished splenic function]. | patients without spleen or with diminished splenic function are at high risk (10-50 times higher than in normal population) of developing life-threatening infections (opsi). mortality from opsi is estimated at 50 to 80% of cases. more frequent causative agents are encapsulated bacteria: streptococcus pneumoniae, haemophilus influenzae type b and neisseria meningitidis. the risk of opsi can be reduced by immunizing patients against these pathogens and by prescribing antibiotic prophylaxis. contin ... | 2013 | 24051976 |
| [antimicrobial susceptibility of community-acquired respiratory tract pathogens isolated from patients in primary hospitals in shanghai from 2007 to 2010]. | to investigate the etiology of community-acquired respiratory tract infections (carti) and the antimicrobial resistance of the major pathogens in primary hospitals in shanghai. | 2013 | 24047808 |
| the effectiveness of conjugate haemophilus influenzae type b vaccine in the gambia 14 years after introduction. | the gambia was the first country in africa to introduce conjugate haemophilus influenzae type b (hib) vaccine, which, as in other developing countries but unlike industrialized countries, is delivered as a 3-dose primary series with no booster. this study assessed its effectiveness 14 years after introduction. | 2013 | 24046305 |
| comparing haemophilus influenzae type b conjugate vaccine schedules: a systematic review and meta-analysis of vaccine trials. | the optimal schedule and the need for a booster dose are unclear for haemophilus influenzae type b (hib) conjugate vaccines. we systematically reviewed relative effects of hib vaccine schedules. | 2013 | 24145955 |
| haemophilus influenzae type b (hib) vaccination position paper – july 2013. | 2013 | 24143842 | |
| nonprotective responses to pediatric vaccines occur in children who are otitis prone. | we recently found that children who experience recurrent otitis media despite individualized care (stringently-defined otitis prone [sop]) do not develop an antibody response to several vaccine candidate protein antigens expressed by streptococcus pneumonia (spn) and haemophilus influenzae. here we sought to determine if these same children also failed to develop antibody to routine pediatric vaccinations. | 2013 | 24141796 |
| evolution of bacterial meningitis diagnosis in são paulo state-brazil and future challenges. | bacterial meningitis (bm) is a severe disease and still represents a serious public health problem with high rates of morbidity and mortality. the most common cases of bm around the world, mainly in brazil, have been caused by neisseria meningitidis, streptococcus pneumoniae, and haemophilus influenzae type b. bacterial culture is the gold-standard technique for bm confirmation, but approximately 50% of suspected cases are not culture-confirmed, due to problems related to improper transportation ... | 2013 | 24141502 |
| antibiotic non-susceptibility among streptococcus pneumoniae and haemophilus influenzae isolates identified in african cohorts: a meta-analysis of three decades of published studies. | management of community-acquired pneumonia caused by streptococcus pneumoniae and haemophilus influenzae type b (hib) can be complicated by emerging antimicrobial non-susceptibility. we conducted a meta-analysis to examine the antibiotic susceptibility of community-acquired invasive infections with s. pneumoniae and hib in africa from 1978 to 2011. with the notable exceptions of widespread trimethoprim/sulfamethoxazole (sxt) and tetracycline non-susceptibility, the majority of pneumococci remain ... | 2013 | 24139883 |
| profile: manhiça health research centre (manhiça hdss). | the manhiça health research centre, established in 1996 in a rural area of southern mozambique, currently follows around 92 000 individuals living in approximately 20 000 enumerated and geo-positioned households. its main strength is the possibility of linking demographic data and clinical data to promote and conduct biomedical research in priority health areas. socio-demographic data are updated twice a year and clinical data are collected on a daily basis. the data collected in manhiça hdss co ... | 2013 | 24159076 |
| haemophilus influenzae type b (hib) vaccination who position paper: july 2013-recommendations. | this article presents the world health organizations (who) evidence and recommendations for the use of haemophilus influenzae type b vaccination from the who position paper on h. influenzae type b (hib) vaccination - july 2013 recently published in the weekly epidemiological record [1]. this position paper summarizes the who position on the inclusion of hib vaccines in all national immunization programmes, recent developments in the field and the potential of different hib immunization schedules ... | 2013 | 24156921 |
| cost-effectiveness and cost utility analysis of three pneumococcal conjugate vaccines in children of peru. | the clinical and economic burden associated with invasive and non-invasive pneumococcal and non-typeable haemophilus influenzae (nthi) diseases is substantial in the latin america and caribbean region, where pneumococcal vaccines have only been introduced to a few countries. this study analyzed the cost-effectiveness and cost utility of three different pneumococcal conjugate vaccines (pcvs) for peru. | 2013 | 24171921 |
| haemophilus influenzae infection of a prosthetic knee joint in a patient with cll: a vaccine preventable disease. | a 71-year-old man was admitted with a 2-day history of the hot and swollen right knee in december 2012. he had undergone a primary cemented right total knee replacement (tkr) in 2002. he also had a history of chronic lymphatic leukaemia (cll), haemolytic anaemia and splenomegaly, and was in partial remission following chemotherapy in 2008. he underwent arthroscopic washout of right tkr on admission. blood cultures on admission and joint fluid specimen grew haemophilus influenzae (hi). the isolat ... | 2013 | 24252835 |
| disinfection of rigid nasal endoscopes following in vitro contamination with staphylococcus aureus, streptococcus pneumoniae, pseudomonas aeruginosa, and haemophilus influenzae. | 2013 | 24274231 | |
| acute bacterial meningitis among children admitted into an iranian referral children's hospital. | bacterial meningitis is a serious threat to global health, particularly in developing countries. the aim of this study was to determine the etiological agents of acute bacterial meningitis, its clinical features, and antibacterial susceptibility among iranian children who were admitted to a referral regional children's hospital. laboratory data as well as symptoms and signs on admission, organism identification and antibiotic susceptibility results, physical examination findings, and neurologic ... | 2013 | 24270138 |
| [the studies of elimination of nontypeable haemophilus influenzae strains using the animal model of infection]. | the intranasal immunization is considered the effective method to induce immunological response in the mucosa and the model useful to develop the vaccine against otitis media due to nontypaeble haemophilus influenzae infections. in the study, elimination of nthi strains isolated from healthy and carrier individuals, varying with several genetic determinants, from mice nasopharynx, lungs and ears tissues and the interactions among strains during mixed infections were evaluated. | 2013 | 24180126 |
| the history of pneumococcal conjugate vaccine development: dose selection. | pneumococcal conjugate vaccines (pcvs) differ in polysaccharide (ps) dose, carrier protein and conjugation method. pcv development proceeded initially upon principles successfully proven in haemophilus influenzae type b (hib) conjugate vaccine development. however, the need to successfully incorporate multiple serotypes while minimizing the total ps dose and total carrier protein load saw some early vaccine candidates fail. dose-range studies of individual serotypes indicated that much lower ps ... | 2013 | 24195479 |
| [concentration of tazobactam/piperacillin in the cerebrospinal fluid of patients with haemophilus influenzae type b meningitis]. | while the incidence of haemophilus influenzae type b (hib) meningitis is expected to decrease with the widespread use of the hib vaccine, the resistance of hib has actually increased. therefore, selection of the initial antibiotics used for treatment must be performed with resistant bacteria, including beta-lactamase negative ampicillin resistant h. influenzae (blnar), in mind. tazobactam/piperacillin (taz/pipc) has a satisfactory minimum inhibitory concentration (mic) against blnar and is a bet ... | 2013 | 24195168 |
| [antimicrobial susceptibility of haemophilus influenzae isolated from pediatric patients at a pediatric facility between 2009 and 2012]. | we examined the antimicrobial susceptibility of 1,208 haemophilus influenzae isolates obtained at a pediatric facility between 2009 and 2012. the percentage distribution of beta-lactamase-non-producing ampicillin (abpc)-sensitive (blnas) strains was 38.2%, that of beta-lactamase-non-producing abpc-intermediately resistant (blnai) strains was 13.9%, that of beta-lactamase-non-producing abpc-resistant (blnar) strains was 38.2%, that of beta-lactamase-producing abpc-resistant (blpar) strains was 5. ... | 2013 | 24195167 |
| [regulation of expression, function, and inflammatory responses of innate immune receptor toll-like receptor-2 (tlr2) during inflammatory responses against infection]. | toll-like receptor-2 (tlr2) is one of the important innate immune receptors that play an important role in recognizing the pathogens and producing inflammatory cytokines. in this review, we focus on the regulatory mechanisms of expression, function and inflammatory responses of tlr2 during pathogenic infection in innate immune cells. we first showed that nontypeable haemophilus influenzae (nthi), an important human pathogen that exacerbates otitis media and chronic obstructive pulmonary diseases ... | 2013 | 24292189 |
| [rapid identification of meningitis due to bacterial pathogens]. | we constructed a new real-time pcr method to detect causative pathogens in cerebrospinal fluid (csf) from patient due to bacterial meningitis. the eight pathogens targeted in the pcr are streptococcus pneumoniae, haemophilus influenzae, streptococcus agalactiae, staphylococcus aurues, neisseria meningitides, listeria monocytogenes, esherichia coli, and mycoplasma pneumoniae. the total time from dna extraction from csf to pcr analysis was 1.5 hour. the pathogens were detected in 72% of the csf sa ... | 2013 | 24291923 |
| maternal supplementation with lgg reduces vaccine-specific immune responses in infants at high-risk of developing allergic disease. | probiotics are defined as live micro-organisms that when administered in adequate amounts confer a health benefit on the host. among their pleiotropic effects, inhibition of pathogen colonization at the mucosal surface as well as modulation of immune responses are widely recognized as the principal biological activities of probiotic bacteria. in recent times, the immune effects of probiotics have led to their application as vaccine adjuvants, offering a novel strategy for enhancing the efficacy ... | 2013 | 24324465 |
| complications of adenotonsillectomy: a case report of meningitis due to dual infection with nontypeable haemophilus influenzae and streptococcus pneumoniae, and a prospective study of the rate of postoperative bacteremia. | bacterial meningitis is a rare complication of adenotonsillectomy. we present a case of meningitis due to nontypeable haemophilus influenzae and streptococcus pneumoniae after adenotonsillectomy. pulsed-field gel electrophoresis patterns indicated that the oral cavity was the source of h. influenzae and s. pneumoniae isolated from the cerebrospinal fluid. blood culture study: as bacteremia is thought to be one of the etiologies of meningitis, we prospectively investigated the rate of bacteremia ... | 2013 | 24396981 |
| molecular epidemiology of nontypeable haemophilus influenzae causing community-acquired pneumonia in adults. | nontypeable haemophilus influenzae (nthi) is an opportunistic pathogen which causes a variety of respiratory infections. the objectives of the study were to determine its antimicrobial susceptibility, to characterize the β-lactam resistance, and to establish a genetic characterization of nthi isolates. ninety-five nthi isolates were analyzed by pulsed field gel electrophoresis (pfge) and multi locus sequence typing (mlst). antimicrobial susceptibility was determined by microdilution, and the fts ... | 2013 | 24349303 |
| post-licensure rapid immunization safety monitoring program (prism) data characterization. | the post-licensure rapid immunization safety monitoring (prism) program is the immunization safety monitoring component of fda's mini-sentinel project, a program to actively monitor the safety of medical products using electronic health information. fda sought to assess the surveillance capabilities of this large claims-based distributed database for vaccine safety surveillance by characterizing the underlying data. | 2013 | 24331080 |
| [antibiotherapy of severe ent infections in children: propositions of the french group of pediatric infectious diseases (pid) of the french society of pediatrics]. | the french group of pediatric infectious diseases (pid) of the french society of pediatrics found necessary to issue in 2011 therapeutic proposals concerning antibiotic treatment in severe ent infections in children (acute mastoiditis, severe sinusitis, peripharyngeal abscess). they took into account, for each clinical situation, published studies and existing guidelines, the most frequently encountered bacterial species, their usual sensitivity to antibiotics, their pharmacokinetic and pharmaco ... | 2013 | 24360297 |
| purulent pericarditis caused by haemophilus parainfluenzae. | bacterial pericarditis is a rare disease in the era of antibiotics. purulent pericarditis is most often caused by staphylococcus aureus, streptococcus pneumoniae, or haemophilus influenzae. the number of h. parainfluenzae infections has been increasing; in rare cases, it has caused endocarditis. we report a case of purulent pericarditis caused by h. parainfluenzae in a 62-year-old woman who reported a recent upper respiratory tract infection. the patient presented with signs and symptoms of peri ... | 2013 | 24391338 |
| comparison of transcription of the haemophilus influenzae iron/heme modulon genes in vitro and in vivo in the chinchilla middle ear. | haemophilus influenzae is a significant cause of childhood otitis media, and also has an absolute growth requirement for heme. recent microarray studies using three h. influenzae isolates were used to propose a putative core of genes responsive to iron and heme levels. included in the core modulon were thirty seven genes that are preferentially expressed under iron/heme limitation, most of which are directly involved with iron and or heme acquisition. in this report, the core iron/heme modulon w ... | 2013 | 24373462 |
| [immunization practices for workers. update recommendations]. | infectious diseases are a major cause of morbidity and mortality in the workplace. worker vaccination against a number of infectious diseases is considered the most effective strategy of primary prevention to control them. | 2013 | 24399343 |
| cell vacuolation induced by haemophilus influenzae supernatants in hep-2 cells. | haemophilus influenzae belongs to respiratory tract microbiota. we observed vacuoles formation in previous studies with h. influenzae culture supernatants, so in this work we characterised that cytotoxic effect. we observed an abundant production of acidic cytoplasmic vacuoles due to the presence of a "vacuolating factor" in h. influenzae supernatants which was characterised as thermolabile. greatest vacuolating activity was observed when utilizing the fraction > 50 kda. the presence of a large ... | 2013 | 24402145 |
| study of adverse events following immunisation with universal and newer vaccines in the serampore ima child clinic over a period of 7 years. | immunisation is an important part of childcare practice. it is one of the most beneficial and cost effective measures for the prevention of diseases. from the previous retrospective studies, it was evident that smallpox has been completely eradicated throughout now-a-days with the wholehearted and sincere efforts of healthcare providers by applying efficient and safe vaccine against smallpox, same is true also to polio which is now close to worldwide eradication and measles and rubella are no lo ... | 2013 | 24475552 |
| the effect of haemophilus influenzae type b and pneumococcal conjugate vaccines on childhood meningitis mortality: a systematic review. | two of the most prevalent causes of severe bacterial meningitis in children, haemophilus influenzae type b (hib) and streptococcus pneumoniae, are preventable by existing vaccines increasingly available in developing countries. our objective was to estimate the dose-specific effect of hib and pneumococcal conjugate vaccines (pcv) on childhood meningitis mortality in low-income countries for use in the lives saved tool (list). | 2013 | 24564188 |
| [susceptibilities of bacteria isolated from patients with lower respiratory infectious diseases to antibiotics (2006)]. | from october 2006 to september 2007, we collected the specimen from 356 patients with lower respiratory tract infections in 14 institutions in japan, and investigated the susceptibilities of isolated bacteria to various antibacterial agents and patients' characteristics. of 414 strains that were isolated from specimen (mainly from sputum) and assumed to be bacteria causing in infection, 407 strains were examined. the isolated bacteria were: staphylococcus aureus 64, streptococcus pneumoniae 96, ... | 2013 | 24649798 |
| vaccine preventable diseases and vaccination coverage in aboriginal and torres strait islander people, australia 2006-2010. | this report outlines the major positive impacts of vaccines on the health of aboriginal and torres strait islander people from 2007 to 2010, as well as highlighting areas that require further attention. hepatitis a disease is now less common in aboriginal and torres strait islander children than in their non-indigenous counterparts. hepatitis a vaccination for aboriginal and torres strait islander children was introduced in 2005 in the high incidence jurisdictions of the northern territory, quee ... | 2013 | 24410428 |
| meningitis due to haemophilus influenzae type f. | with the decline in the rate of infections caused by haemophilus influenzae serotype b since the widespread vaccination, non-b serotypes should be considered as potential pathogenic agents in children with invasive disease younger than 5 years old. we report the case of an immunocompetent 1-year-old boy with haemophilus influenzae type f meningitis. the agent was identified in cerebrospinal fluid and blood cultures. serotyping was performed by tests using polyclonal sera and confirmed by polymer ... | 2013 | 24488395 |
| [haemophilus influenzae]. | 2013 | 24522312 | |
| molecular insights of co-trimoxazole resistance genes in haemophilus influenzae isolated in malaysia. | in the last few decades, co-trimoxazole (sxt), an antibacterial combination of trimethoprim and sulfamethoxazole, has been used for treatment of upper respiratory tract infection due to haemophilus influenzae. the usage of this antibiotic has become less important due to emergence of sxt-resistant strains worldwide. most reports associate sxt resistance to the presence of variants of dihydrofolate reductase (dhfr) dfra genes which are responsible for trimethoprim resistance; while the sulfametho ... | 2013 | 24522126 |
| immunogenicity of haemophilus influenzae type b protein conjugate vaccines in very low birth weight infants. | 2013 | 24569312 | |
| [antibiotic resistant genes]. | genes encoding antibiotic-resistant factors may be exogenous or endogenous. most exogenous genes originate from antibiotic-producing organisms. bacteria can transfer antibiotic-resistant genes among themselves using gene-exchanging systems, such as plasmids, bacteriophages or integrative and conjugative elements. one of the resistance mechanisms is inactivation of antibiotics by modification or decomposition. methicillin-resistant staphylococcus aureus, penicillin-resistant streptococcus pneumon ... | 2013 | 24605547 |
| trivac decision-support model for evaluating the cost-effectiveness of haemophilus influenzae type b, pneumococcal and rotavirus vaccination. | the trivac decision support model has been used widely in latin america and other regions to help national teams evaluate the cost-effectiveness of haemophilus influenzae type b (hib) vaccine, pneumococcal conjugate vaccine (pcv) and rotavirus vaccine (rv). we describe the structure and functioning of this model, and identify the parameters with the greatest influence on the results. the trivac model is a spreadsheet software program that calculates incremental cost-effectiveness ratios (icers) ... | 2013 | 23777686 |
| population-based incidence of invasive haemophilus influenzae and pneumococcal diseases before the introduction of vaccines in japan. | before the introduction of vaccines, the incidence of bacterial meningitis among children aged 28 days to 5 years was 8.48, haemophilus influenzae type-b meningitis was 5.65 and streptococcus pneumoniae meningitis was 1.85 per 100,000 person-years in hokkaido, japan. the incidence of bacteremia caused by s. pneumoniae was 60.15 and h. influenzae was 18.80. | 2013 | 23804122 |
| "affect of anaerobiosis on the antibiotic susceptibility of h. influenzae". | haemophilus influenzae is a human-restricted facultative anaerobe which resides mostly in the oropharynx. the majority of isolates recovered from the throat are unencapsulated commensals (nthi), but depending on host susceptibility they cause bronchitis, otitis media and on occasion bacteremia and meningitis. because of the variable oxygen availability in the various niche permitting bacterium replication, the organism must thrive in well oxygenated surfaces, such as pharyngeal epithelium to ano ... | 2013 | 23803418 |
| immune responses in infants whose mothers received tdap vaccine during pregnancy. | the effect of maternal tdap vaccination on infant immunologic responses to routine pediatric vaccines is unknown. | 2013 | 23799518 |
| how french physicians manage with a future change in the primary vaccination of infants against diphtheria, tetanus, pertussis and poliomyelitis? a qualitative study with focus groups. | as in other european countries, the french vaccination schedule changes according to epidemiological and socio-economic situations. further changes are planned for 2013, including the withdrawal of one dose for primary vaccination against diphtheria, tetanus, polio, pertussis and haemophilus influenzae. a partnership between the french technical vaccination committee and the french institute for health and medical research designed a study to assess primary care physicians' agreement about this ... | 2013 | 23782853 |
| mortality and neurodevelopmental outcomes of acute bacterial meningitis in children aged <5 years in pakistan. | significant neurodevelopmental sequelae are known to occur after acute bacterial meningitis (abm). this study determined the burden of such sequelae in pakistani children aged <5 years to guide policies for haemophilus influenzae type b (hib) and pneumococcal vaccination. | 2013 | 23773600 |
| impact of haemophilus influenzae type b conjugate vaccine in mongolia: prospective population-based surveillance, 2002-2010. | bacterial meningitis is associated with high mortality and long-term complications. this study assessed the impact of haemophilus influenzae type b (hib) conjugate vaccine on childhood bacterial meningitis in ulaanbaatar, mongolia. | 2013 | 23773599 |
| effectiveness of haemophilus influenzae type b conjugate vaccine on radiologically-confirmed pneumonia in young children in pakistan. | the effectiveness of haemophilus influenzae type b (hib) vaccine in preventing severe pneumonia in asian children has been questioned, and many large asian countries yet to introduce hib conjugate vaccine in immunization programs. the primary objective of this study was to assess hib conjugate vaccine effectiveness (ve) on radiologically-confirmed pneumonia in children born after introduction of hib conjugate vaccine in pakistan. | 2013 | 23773598 |
| impact of introduction of the haemophilus influenzae type b conjugate vaccine into childhood immunization on meningitis in bangladeshi infants. | some asian countries have been reluctant to adopt haemophilus influenzae type b (hib) conjugate vaccination because of uncertainty over disease burden. we assessed the impact of introduction of hib conjugate vaccine into the expanded program on immunization in bangladesh on purulent and laboratory-confirmed h influenzae meningitis. | 2013 | 23773597 |
| impact and cost-effectiveness of haemophilus influenzae type b conjugate vaccination in india. | to estimate the potential health impact and cost-effectiveness of nationwide haemophilus influenzae type b (hib) vaccination in india. | 2013 | 23773596 |
| cost-effectiveness of haemophilus influenzae type b conjugate vaccine in low- and middle-income countries: regional analysis and assessment of major determinants. | to estimate the cost-effectiveness of haemophilus influenzae type b (hib) conjugate vaccine in low- and middle-income countries and identify the model variables, which are most important for the result. | 2013 | 23773595 |
| follow-up of cases of haemophilus influenzae type b meningitis to determine its long-term sequelae. | to measure physical and neurologic impact of haemophilus influenzae type b (hib) meningitis on surviving children through short- and long-term follow-up. | 2013 | 23773594 |
| incidence of haemophilus influenzae type b disease in the gambia 14 years after introduction of routine haemophilus influenzae type b conjugate vaccine immunization. | haemophilus influenzae type b (hib) conjugate vaccine was first introduced in africa in the gambia in 1997 as a primary 3-dose course in infancy with no booster, and was followed by the disappearance of invasive hib disease by 2002. a cluster of cases detected non-systematically in post-infant children in 2005-2006 raised the question of the need for a booster dose. the objective of this study was to determine the incidence of invasive hib disease in gambian children 14 years after the introduct ... | 2013 | 23773593 |
| incidence of radiologically-confirmed pneumonia and haemophilus influenzae type b carriage before haemophilus influenzae type b conjugate vaccine introduction in central vietnam. | to determine the incidence of radiologically-confirmed pneumonia (rcp) and haemophilus influenzae type b (hib) carriage in central vietnam as a baseline data before hib conjugate vaccine introduction. | 2013 | 23773592 |
| bacterial meningitis surveillance in the eastern mediterranean region, 2005-2010: successes and challenges of a regional network. | to describe epidemiology of bacterial meningitis in the world health organization eastern mediterranean region countries and assist in introduction of new bacterial vaccines. | 2013 | 23773590 |
| haemophilus influenzae type b disease among children in rural mozambique: impact of vaccine introduction. | haemophilus influenzae type b (hib) conjugate vaccine has dramatically reduced invasive hib disease worldwide. yet, data on protection against pneumonia and among children with hiv are limited. we evaluated the impact of hib conjugate vaccine introduction in 2009 in a rural, high-hiv prevalence area in mozambique. | 2013 | 23773589 |
| evaluation of the effectiveness of haemophilus influenzae type b conjugate vaccine introduction against radiologically-confirmed hospitalized pneumonia in young children in ukraine. | haemophilus influenzae type b (hib) conjugate vaccine was included into the national vaccination schedule of ukraine in 2006. the objective of this study was to demonstrate the effectiveness of hib conjugate vaccine against radiologically-confirmed hospitalized pneumonia in children. | 2013 | 23773588 |
| progress towards demonstrating the impact of haemophilus influenzae type b conjugate vaccines globally. | 2013 | 23773587 | |
| resistance to complement-mediated killing and igm binding to non-typeable haemophilus influenzae is not altered when ascending from the nasopharynx to the middle ears in children with otitis media. | we have previously found that non-typeable haemophilus influenzae (nthi) collected from the middle ear of children with otitis media (om) exhibit increased levels of complement resistance compared to nthi collected from the nasopharynx. however, it is unknown whether bacteria develop complement resistance in the middle ear, or whether resistance is present when residing in the nasopharynx. the objective of this study was to investigate whether the levels of complement resistance of isolates coll ... | 2013 | 23775521 |
| identification of haemophilus influenzae clones associated with invasive disease a decade after introduction of h. influenzae serotype b vaccination in italy. | the introduction of haemophilus influenzae serotype b (hib) conjugate vaccines has changed the epidemiology of invasive h. influenzae disease, with a shift in the predominant serotype from hib to nonencapsulated h. influenzae (nchi). the objective of this study was to identify the genotypes/clones associated with invasive h. influenzae disease in italy. eighty-seven h. influenzae strains isolated in the years 2009 to 2011 within the national surveillance of invasive bacterial disease program wer ... | 2013 | 23761663 |
| clinical manifestations and microbiology of acute otitis media with spontaneous otorrhea in children. | in taiwan, clinical and microbiological data on acute otitis media (aom) with spontaneous otorrhea in children are limited. | 2013 | 23757372 |
| cd4+ cd31+ recent thymic emigrants in chd7 haploinsufficiency (charge syndrome): a case. | lymphocyte counts <2000 cells/μl are associated with early death in infants with charge (coloboma, heart defect, atresia choanae, retarded growth and development, genital hypoplasia, ear anomalies/deafness) syndrome and chd7 haploinsufficiency. absence of recent thymic emigrants is also accompanied by an omenn-like syndrome and infant death in chd7 haploinsufficiency. studies positively identifying recent thymic emigrants, in relation to chd7 haploinsufficiency, are non-existent. thirty two mont ... | 2013 | 23747993 |
| [investigation of the sudden infant death syndrome: a multidisciplinary approach is required]. | the concept of sudden infant death syndrome (sids) is defined as the sudden, unexpected death of an infant less than a year old which remains unexplained after in-depth investigations comprising a complete autopsy, biological analyses, and a clinical examination of the circumstances surrounding the death. this definition underlines the importance of finding the cause of this disease in order to improve preventative measures to reduce the number of deaths due to sudden infant death syndrome. amon ... | 2013 | 23747667 |
| microbiology of bacteria causing recurrent acute otitis media (aom) and aom treatment failure in young children in spain: shifting pathogens in the post-pneumococcal conjugate vaccination era. | to prospectively identify the bacterial aetiology and antimicrobial susceptibility of problematic (recurrent and treatment failure) acute otitis media in spanish children several years after the introduction of 7-valent pneumococcal conjugate vaccine. | 2013 | 23746414 |
| antimicrobial resistance among respiratory haemophilus influenzae isolates from pulmonology services over a six-year period. | respiratory tract infections (rti) are frequently caused by haemophilus influenzae. widespread antibacterial resistance among respiratory microorganisms complicates empirical rti treatment. therefore, national data on antibiotic resistance for h. influenzae are important for guiding optimal antibiotic choice. | 2013 | 23746341 |
| human neutrophil elastase degrades splunc1 and impairs airway epithelial defense against bacteria. | acute exacerbations of chronic obstructive pulmonary disease (aecopd) are a significant cause of mortality of copd patients, and pose a huge burden on healthcare. one of the major causes of aecopd is airway bacterial (e.g. nontypeable haemophilus influenzae [nthi]) infection. however, the mechanisms underlying bacterial infections during aecopd remain poorly understood. as neutrophilic inflammation including increased release of human neutrophil elastase (hne) is a salient feature of aecopd, we ... | 2013 | 23741370 |
| relationship with original pathogen in recurrence of acute otitis media after completion of amoxicillin/clavulanate: bacterial relapse or new pathogen. | we sought to determine whether recurrent acute otitis media (raom) occurring within 30 days of amoxicillin/clavulanate treatment was caused by bacterial relapse or new pathogens. | 2013 | 23736142 |
| bacterial meningitis post-pcv7: declining incidence and treatment. | the epidemiology of bacterial meningitis in the united states has changed tremendously in the past 20 years. since the introduction of the haemophilus influenzae type b vaccine in 1988, the incidence of h. influenzae type b meningitis has declined by at least 97%, and streptococcus pneumoniae has emerged as the most common etiologic agent. the pcv7 (7-valent pneumococcal conjugate vaccine [prevnar]; wyeth pharmaceuticals) vaccine, which targets 7 pneumococcal serotypes, was introduced in 2000 an ... | 2013 | 23736074 |
| haemophilus influenzae serotype a invasive disease, alaska, usa, 1983-2011. | before introduction of haemophilus influenzae type b (hib) vaccines, rates of hib disease in alaska's indigenous people were among the highest in the world. vaccination reduced rates dramatically; however, invasive h. influenzae type a (hia) disease has emerged. cases of invasive disease were identified through alaska statewide surveillance during 1983-2011. of 866 isolates analyzed for serotype, 32 (4%) were hia. no hia disease was identified before 2002; 32 cases occurred during 2002-2011 (p<0 ... | 2013 | 23735653 |
| corticosteroids for acute bacterial meningitis. | in experimental studies, the outcome of bacterial meningitis has been related to the severity of inflammation in the subarachnoid space. corticosteroids reduce this inflammatory response. | 2013 | 23733364 |
| [predictors of one year mortality among immunocompetent adults hospitalized for community-acquired pneumonia]. | mortality increases in adults, especially in older adults, after recovery from an episode of community-acquired pneumonia (cap). | 2013 | 23732485 |
| differential activation of eosinophils by bacteria associated with asthma. | it has been suggested that there is a complex interaction between microbiota and various human diseases. some bacteria have been reported to be involved in the inception and progression of asthma, and others in the protection against asthma. we know very little about the mechanisms by which bacteria do harm or good with regard to asthma. this study investigated whether bacteria exert differential effects on the functions of eosinophils, major effector cells in airway inflammation in asthma. | 2013 | 23711849 |
| programming of the lung in early life by bacterial infections predisposes to chronic respiratory disease. | there is emerging evidence that chronic respiratory diseases such as asthma and emphysema may originate in early life. respiratory infections with certain bacterial pathogens such as chlamydia, haemophilus influenzae and streptococcus pneumoniae in early life may promote permanent deleterious changes in immunity, lung structure, and function that predispose to, or increase the severity of chronic respiratory diseases in later life. for example, these infections increase immune responses, which d ... | 2013 | 23722921 |
| computational insights into the mechanism of inhibition of oass-a by a small molecule inhibitor. | o-acetylserine sulfhydrylase (isoform a, oass-a) is a plp-dependent enzyme involved in the last step of cysteine biosynthesis in many pathogens. many microorganisms use cysteine as the main building block for sulfur-containing antioxidants, and cysteine depletion in several pathogens resulted in a reduced antibiotic resistance, thus leading to the identification of oass as novel suitable molecular targets to overcome antimicrobial resistances. the precise molecular mechanism of oass-a inhibition ... | 2013 | 27481665 |
| identification of phase-variable genes that may contribute to nontypeable haemophilus influenzae nasopharyngeal colonization in humans contributes to our understanding of specific host-pathogen interactions. | 2013 | 23715662 | |
| a new human colonization model for nontypeable haemophilus influenzae. | 2013 | 23715657 | |
| immunogenicity and safety of a meningococcal serogroup a, c, y and w glycoconjugate vaccine, acwy-tt. | a quadrivalent meningococcal serogroup a, c, w and y conjugate vaccine (acwy), utilising tetanus toxoid (tt) as its carrier protein (acwy-tt; nimenrix™, glaxosmithkline vaccines, rixensart, belgium) has been demonstrated to be safe and immunogenic when administered to young children from 12 months of age, older children, adolescents, and adults. administration of a single dose of acwy-tt induces protective serum bactericidal antibodies against all four serogroups as well as good antibody persist ... | 2013 | 23712402 |
| gene set enrichment analysis identifies key innate immune pathways in primary graft dysfunction after lung transplantation. | we hypothesized alterations in gene expression could identify important pathways involved in transplant lung injury. broncho alveolar lavage fluid (balf) was sampled from donors prior to procurement and in recipients within an hour of reperfusion as part of the niaid clinical trials in organ transplantation study. twenty-three patients with grade 3 primary graft dysfunction (pgd) were frequency matched with controls based on donor age and recipient diagnosis. rna was analyzed using the human gen ... | 2013 | 23710539 |
| vaccines as a tool to estimate the burden of severe influenza in children of low-resourced areas (november 30-december 1, 2012, les pensieres, veyrier-du-lac, france). | there is an increasing focus on influenza in low-resourced areas as a vaccine-preventable cause of severe lower respiratory disease in young children, especially among those under two years of age. the extent of the disease burden is unclear: current etiologic studies may underestimate the impact of influenza if recognized or unrecognized infection occurs some time before severe disease manifestations prompt specimen collection for diagnosis. because of various methodological challenges, a vacci ... | 2013 | 23707161 |
| prospective safety monitoring of haemophilus influenzae type b and heptavalent pneumococcal conjugate vaccines in kagoshima, japan. | haemophilus influenzae type b (hib) conjugate vaccine (prp-t) and heptavalent pneumococcal conjugate vaccine (pcv7) were introduced in japan in december 2008 and february 2010, respectively. the concurrent administration of these vaccines is routinely performed worldwide. however, the safety of the simultaneous administration of these vaccines has not been fully evaluated in japan, because it has rarely been performed thus far. we conducted a 2-year prospective, observational, multicenter study ... | 2013 | 23698486 |
| haemophilus influenzae serotype f as a rare cause of septic arthritis. | non-type b haemophilus influenzae emerges as a new pathogen in the post h. influenzae serotype b vaccine era. we describe a case of polyarticular septic arthritis caused by h. influenzae serotype f in an adult. the patient was successfully treated with surgical debridement and antibiotic. to the best of our knowledge, this is the fourth reported case of h. influenzae serotype f septic arthritis in adults. | 2013 | 23688572 |
| hpaec-pad method for the analysis of alkaline hydrolyzates of haemophilus influenzae type b capsular polysaccharide. | a gradient method has been devised for the rapid analysis of alkaline hydrolyzates of haemophilus influenzae type b (hib) capsular polysaccharide-based vaccines by high-performance anion exchange chromatography with pulsed amperometric detection (hpaec-pad). as compared with published procedures, peak shape and sensitivity were significantly improved with this approach, analysis time was short and there was little interference from impurities. the limits of detection and quantification were esta ... | 2013 | 23681893 |
| disinfection of rigid nasal endoscopes following in vitro contamination with staphylococcus aureus, streptococcus pneumoniae, pseudomonas aeruginosa, and haemophilus influenzae. | if not adequately cleaned, rigid nasal endoscopes (rnes) have the potential to cause iatrogenic cross-contamination. | 2013 | 23680971 |
| etiology of bacterial meningitis in children in tuzla canton. | bacterial meningitis is one of the most serious infectious diseases in childhood. | 2013 | 23678830 |
| intraperitoneal inoculation of haemophilus influenzae local isolates in balb/c mice model in the presence and absence of virulence enhancement agents. | haemophilus influenzae (hi), predominantly type b accounts for approximately 4% of cases of community-acquired and nosocomial meningitis, in adults. the objective of this study was to evaluate the pathogenicity of local hi isolates (type b, f and non-typable) in balb/c mice in the presence of virulence enhancement agents. | 2013 | 23867671 |
| design and validation of a supragenome array for determination of the genomic content of haemophilus influenzae isolates. | haemophilus influenzae colonizes the human nasopharynx as a commensal, and is etiologically associated with numerous opportunistic infections of the airway; it is also less commonly associated with invasive disease. clinical isolates of h. influenzae display extensive genomic diversity and plasticity. the development of strategies to successfully prevent, diagnose and treat h. influenzae infections depends on tools to ascertain the gene content of individual isolates. | 2013 | 23865594 |
| staphylococcal ecb protein and host complement regulator factor h enhance functions of each other in bacterial immune evasion. | staphylococcus aureus is a major human pathogen causing more than a tenth of all septicemia cases and often superficial and deep infections in various tissues. one of the immune evasion strategies of s. aureus is to secrete proteins that bind to the central complement opsonin c3b. one of these, extracellular complement binding protein (ecb), is known to interfere directly with functions of c3b. because c3b is also the target of the physiological plasma complement regulator, factor h (fh), we stu ... | 2013 | 23863906 |
| immune competence after alemtuzumab treatment of multiple sclerosis. | to determine the immunocompetency of patients with multiple sclerosis treated with the lymphodepleting humanized monoclonal antibody alemtuzumab. | 2013 | 23925762 |
| review of phosphocholine substituents on bacterial pathogen glycans: synthesis, structures and interactions with host proteins. | among the non-carbohydrate components of glycans, the addition of phosphocholine (chop) to the glycans of pathogens occurs more rarely than acetylation or methylation, but it has far more potent biological consequences. these arise from chop's multiple interactions with host proteins, which are important at all stages of the infection process. these stages include initial adherence to cells, encountering the host's innate immune system and then the adaptive immune system. thus, in the initial st ... | 2013 | 23911414 |
| nasopharyngeal bacterial flora in healthy preschool children during winter-spring months. | the paper aimed to determine the incidence of colonization of streptococcus pyogenes, streptococcus pneumoniae, haemophilus influenzae type b and neisseria meningitidis in the nasopharynges of healthy children in two preschool institutions during winter and spring months, without using antimicrobial treatment or serotyping of these bacteria. in addition to colonization of the above bacteria, the research that continued for 3 months monitored the length of their persistence in and disappearance f ... | 2013 | 23940983 |
| acute lower respiratory infections on lung sequelae in cambodia, a neglected disease in highly tuberculosis-endemic country. | little is known about post-infectious pulmonary sequelae in countries like cambodia where tuberculosis is hyper-endemic and childhood pulmonary infections are highly frequent. we describe the characteristics of hospitalized cambodian patients presenting with community-acquired acute lower respiratory infections (alri) on post-infectious pulmonary sequelae (alrips). | 2013 | 23937802 |
| heterozygous alterations of tnfrsf13b/taci in tonsillar hypertrophy and sarcoidosis. | tnfrsf13b/taci defects have been associated with cvid pathogenesis and/or phenotype, especially the development of benign lymphoproliferation and autoimmunity. our purpose was to investigate the role of tnfrsf13b/taci defects in the pathogenesis of two common lymphoproliferative disorders, namely, sarcoidosis and tonsillar hypertrophy (th). 105 patients (71 with sarcoidosis and 34 with th, including 19 without infectious causative and 15 due to haemophilus influenzae) were analyzed for tnfrsf13b ... | 2013 | 23956760 |
| pneumonia in low and middle income countries: progress and challenges. | pneumonia remains the leading cause of childhood mortality and the most common reason for adult hospitalisation in low and middle income countries, despite advances in preventative and management strategies. in the last decade, pneumonia mortality in children has fallen to approximately 1.3 million cases in 2011, with most deaths occurring in low income countries. important recent advances include more widespread implementation of protein-polysaccharide conjugate vaccines against haemophilus inf ... | 2013 | 23956020 |
| otitis media: diagnosis and treatment. | acute otitis media is diagnosed in patients with acute onset, presence of middle ear effusion, physical evidence of middle ear inflammation, and symptoms such as pain, irritability, or fever. acute otitis media is usually a complication of eustachian tube dysfunction that occurs during a viral upper respiratory tract infection. streptococcus pneumoniae, haemophilus influenzae, and moraxella catarrhalis are the most common organisms isolated from middle ear fluid. management of acute otitis media ... | 2013 | 24134083 |
| evaluation of 13-valent pneumococcal conjugate vaccine and concomitant meningococcal group c conjugate vaccine in healthy infants and toddlers in spain. | given the concurrent administration of multiple vaccines during routine pediatric immunizations, efforts to elucidate the potential interference of any vaccine on the immune response to the concomitantly administered antigens are fundamental to prelicensure clinical research. | 2013 | 24004465 |