Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| studies on plasmodium ookinetes: ii. in vitro formation of plasmodium berghei ookinetes. | 1977 | 21234 | |
| cyclophosphamide-induced specific suppression of the protective immune response to rodent malaria. | nonspecific and specific chemosuppression of the immune response to plasmodium berghei protective antigens were investigated. specific immunosuppression was defined operationally as the selective suppression of the protective response to the parasite in mice injected with a combination of gamma-irradiated infected mouse erythrocytes (gammapb) and cyclophosphamide (cy) with continued responsiveness to sheep erythrocytes (srbc). after initial treatment (gammapb + cy), mice were injected with gamma ... | 1977 | 65425 |
| immunosuppression in murine malaria. i. response to type iii pneumococcal polysaccharide. | acute plasmodium yoelii yoelii and chronic plasmodium berghei malaria infections of cba mice were accompanied by a reduced capacity to give an antibody response to type iii pneumococcal polysaccharide (siii). the depression of response initiated by acute malaria persisted for several weeks after recovery from clinical infection. during chronic infection, and at the peak of acute parasitaemia, virtually no response to siii was detected. a substance which crossreacted serologically with siii was f ... | 1977 | 67996 |
| antifolate studies. activities of 40 potential antimalarial compounds against sensitive and chlorguanide triazine resistant strains of folate-requiring bacteria and escherichia coli. | as part of the search for new antimalarial drugs, a screening program was developed using sensitive and chlorguanide triazine (cgt, cycloguanil) resistant strains of the folate-requiring bacteria, streptococcus faecium durans, lactobacillus casei, and pediococcus cerevisiae. the activities of 40 compounds have been studied against these strains and escherichia coli. observations have been made on the points of 50% growth inhibition, the fold increase of resistance shown to each compound by the r ... | 1977 | 137981 |
| [morphologic changes in erythrocytes following the penetration and intra-erythrocyte development of plasmodium berghei in the mouse]. | 1977 | 345925 | |
| plasmodium berghei: high pressure liquid chromatographic analysis of nucleotides from erythrocyte-free malarial parasites. | 1977 | 195832 | |
| cell mediated and humoral immunity in experimental plasmodium berghei infection. | adoptive passive transfer of immunity to plasmodium berghei infection has been investigated in an inbred strain of swiss mice. the mice were made hyperimmune by repeated passage of 10(3) parasites and subsequent therapy with an antimalarial drug. immune sera and cells obtained from thymus, spleen and peritoneal exudate were transferred to normal animals which were subsequently challenged with standard doses of p. berghei. it was observed that: (a) immune serum in high doses (0.5 ml/mouse) enhanc ... | 1977 | 343309 |
| conformational studies of a family of related antimalarial phenanthrene amino alcohols. | a conformational study utilizing quantum chemical methods was performed on a family of antimalarial alpha-(piperidyl)-3,6-bis(trifluoromethyl)-9-phenanthrenemethanols whose structures differ by the placement of the substituent on either the 2,3, or 4 position of the piperidyl ring. the antimalarial activity of these 3-substituted compounds has been shown experimentally to be highly stereospecific while the 2-substituted compounds are not and the 4-substituted compounds are inactive. in this stud ... | 1977 | 319232 |
| plasmodium berghei: polyribosome profiles in the spleens of infected mice. | 1977 | 320032 | |
| protection of mice against babesia spp. and plasmodium spp. with killed corynebacterium parvum. | mice which had been pre-treated with killed corynebacterium parvum given intravenously or intraperitoneally, but not subcutaneously, were completely resistant to infection with babesia microti or b. rodhaini, and were protected from death caused by plasmodium vinckei or p. chabaudi infection. there is evidence that the parasites died within circulating erythrocytes. this occurred much too soon for a specific antibody response to be evoked, and no antibody could be detected by the indirect fluore ... | 1977 | 320544 |
| exacerbation of experimental trypanosoma cruzi infection in mice by concomitant malaria. | the effect of malaria on the chronic phase of chagas' disease was investigated in mice. the animals were given plasmodium bergheri-infected red blood cells 2 to 12 months after their initial inoculation with trypomastigotes of 3 different strains of trypanosoma cruzi (y. cl and gilmar). in all the experiments carried out with one of the strains (cl), a somewhat variable but always considerable percentage of mice (average 39%) relapsed in to the acute phase of chagas' disease. this relapse was ch ... | 1977 | 413912 |
| [light microscopic and scanning electron microscopic observations on phagocytosis of plasmodium berghei infected erythrocytes by mouse macrophages [author's transl)]. | peritoneal macrophages from mice were cultured in leighton tubes for 2 hours. thereafter suspensions of washed red blood corpuscles originating from plasmodium berghei-infected mice were offered to the cultured cells for phagocytosis. after 15 minutes of incubation 13,5% of the macrophages showed phagocytized parasites if the peritoneal cells came from malariaimmune mice. cells from normal mice or from infected mice had lower rates (4,8/9,1%). after an incubation of 3 hours about 50% of the cell ... | 1977 | 414386 |
| changes in serum, liver, fat pad and thymus lipid levels in adult rats infected with plasmodium berghei. | 1977 | 370086 | |
| plasmodium berghei: relationship between mitosis and erythropoiesis in spleen cells of infected rats. | 1977 | 598448 | |
| spleen-derived mononuclear cell chemotactic factor in malaria infections: a possible mechanism for splenic macrophage accumulation. | 1977 | 402418 | |
| studies on the invasive ability of malarial merozoites (plasmodium berghei). | studies were performed to evaluate several methods for the artificial removal of plasmodium berghei merozoites from infected mouse erythrocytes. these methods, many of which have been reported to yield free parasites capable of establishing a patent infection when injected into a suitable host, included nh4c1-mediated lysis, complement-mediated immune lysis, pressure filtration, and multiple-burst and continuous-flow sonication. free parasites isolated from infected mouse blood were examined in ... | 1977 | 405468 |
| electrophoresis of glucose-6-phosphate and 6-phosphogluconate dehydrogenases in erythrocytes from malaria-infected animals. | electrophoresis of red-cell extracts from control and malaria-infected animals on 'cellogel' demonstrated the absence of g-6-pd activity of 'parasite' origin, although 6-pgd activity was present. an identical 6-pgd isoenzyme was found in mice, rats and hamsters infected with the same strain of plasmodium berghei indicating the parasite as the source of the enzyme. a similar 6-pgd isoenzyme was also found in a few preliminary experiments with p. knowlesi-infected monkey erythrocytes. the implicat ... | 1977 | 405935 |
| ficoll fractionation for the separation of parasitized erythrocytes from malaria infected blood. | separation and concentration of parasitized erythrocytes from infected blood was achieved by centrifugation of a sample placed in a layer on top of a cushion of a ficoll solution with a critical density. pure suspensions of parasitized erythrocytes were obtained from plasmodium berghei infected rodent blood, whereas results with p. vivax infected monkey (aotus trivirgatus) blood were partially successful. titration experiments revealed that the parasitized erythrocytes obtained by ficoll fractio ... | 1977 | 408020 |
| modifications of primaquine as antimalarials. 1. 5-phenoxy derivatives of primaquine. | various 5-phenoxy derivatives of primaquine have been prepared which are more active and less toxic than the parent compound in murine and monkey antimalarial screens. an improved method for the phthalimido alkylation of amines is described. | 1977 | 408489 |
| synthesis of 2-benzyloxy and 2-benzylthio analogues of primaquine as potential antimalarials. | a series of 2-benzyloxy and 2-benzylthio analogues of primaquine has been synthesized and evaluated against plasmodium berghei in the mouse and plasmodium cynomolgi in the rhesus monkey. 8-aminoquinoline toxicity, as measured in the rane mouse screen, was reduced, and these compounds showed significant blood schizonticidal antimalarial activity in mice. in monkeys, significant tissue-schizonticidal activity was observed. | 1977 | 409843 |
| antimalarials. 10. synthesis of 4-substituted primaquine analogues as candidate antimalarials. | primaquine (i) has been extensively used in combination with other drugs in the radical cure of relapsing malaria as well as for prophylaxis or the interruption of transmission. this, coupled with the activity data reported for 4-methylprimaquine (ii), has led to the synthesis of a series of 14 4-substituted analogues of i. in addition, three side-chain analogues of ii were prepared. the compounds were tested for suppressive antimalarial activity against plasmodium berghei in the rane mouse scre ... | 1977 | 411930 |
| survival of aegyptianella pullorum, anaplasma marginale and various parasitic protozoa following prolonged storage in liquid nitrogen. | various protozoa species were examined using in vivo and in vitro methods to determine their ability to survive prolonged periods of storage in liquid nitrogen. the following protozoan species were successfully recovered after they had been cryopreserved for a period over 10 years: trypanosoma lewisi, t. cruzi, t. congolense, t. brucei, t. rhodesiense, t. gambiense, t. evansi, t. equinum, t. equiperdum, leishmania donovani, plasmodium berghei, p. praecox (relictum), babesia rodhaini and b. canis ... | 1977 | 919686 |
| structure of aplasmomycin. | a new antibiotic, aplasmomycin, was isolated from a broth cultivated with a marine isolate of actinomycete, and inhibits gram-positive bacteria in vitro and plasmodium berghei in vivo. it is a natural ionophore and the structure of the ag-salt was solved by an x-ray crystallographic analysis. it has symmetric structure having boron in the centre of the molecule. | 1977 | 924893 |
| 5-aryloxy-6-methoxy-8-aminoquinolines as potential prophylactic antimalarials. | 5-(p-anisyloxy)-6-methoxy-8-(5-isopropylaminopentylamino)quinoline was resynthesized for evaluation in the plasmodium berghei and monkey prophylactic (plasmodium cynomolgi) tests. a new primary amine, three secondary amines, and one structurally modified side-chain analog of the 5-aryloxy series were also prepared. none of these compounds showed significant antimalarial or prophylactic activity. | 1976 | 824437 |
| reduced 8-aminoquinoline analogues as potential antimalarial agents. | the synthesis of 1-alkyl-8-(aminoalkylamino)-6-methyl1-1,2,3,4-tetrahydroquinolines, 8-(4'-amino-1'-methylbutylamino)-6-methoxy-1-methyl1-1,2-dihydroquinoline, 5-substituted 8-(4'-amino-1'-methylbutylamino)-1-methyl-1,2-dihydroquinolines, 8-alkylamino-1-(2-n,n-diethylaminoethyl)-6-methoxy-1,2,3,4-tetrahydroquinolines, 1-)2-n,n-diethylaminoethyl)-6-methoxy-1,2,3,4-tetrahydroquinoline, 1-(2-n,n-diethylaminoethyl)-8-(2-n,n-diethylaminoethylamino)-6-methoxy-1,2,3,4-tetrahydroquinoline, and 2-substit ... | 1976 | 824447 |
| difference in antimalarial activity between certain amino alcohol diastereomers. | a striking difference in antimalarial activity between the diastereomers of 6-bromo-alpha-[2-(1-methylpiperidyl)]-9-phenanthrenemethanol, alpha-(3-peperidyl)-3,6-bis(trifluoromethyl)-9-phenanthrenemethanol, and alpha-(3-piperidyl)-2,8-bis(trifluoromethyl)-4-quinolinemethanol was observed. a possible explanation involving the n-o distance and active site binding requirements is suggested. | 1976 | 1107548 |
| [antimicrobial action of the combination sulfamoxole/trimethoprim in vivo (author's transl)]. | the experimental infections of the mouse by gram-positive and gram-negative germs are effectively treated with the combination of n1-(4,5-dimethyl-2-oxazolyl)-sulfanilamide (sulfamoxole) and 2,4-diamino-5-(3,4,5-trimethoxy-benzyl)-pyrimidine (trimethoprim) (cn 3123, nevin, supristol). the potentiating effect of both substances is demonstrated by the calculated index of the synergistic effect. the therapeutic efficacy of the combination sulfamoxole/trimethoprim is proved by two models of experime ... | 1976 | 782473 |
| protective activity in sera from mice immunized against plasmodium berghei. | 1976 | 784936 | |
| specific lymphocyte transformation in murine malaria. | lymphoblast transformation tests were performed on convalescent rats and mice, after infection with plasmodium berghei had been reduced to latency. spleen cells from immune animals reacted in vitro to specific plasmodial antigen and not to control antigen produced from non infected rbc. the response in vitro was dependent on the concentration of the antigen and the time of exposure to it. a correlation was observed between the parasitaemia of the convalescent animal during its acute infection an ... | 1976 | 785850 |
| plasmodium berghei: use of free blood stage parasites to demonstrate protective humoral activity in the serum of recovered rats. | 1976 | 786704 | |
| plasmodium berghei: the spleen in sporozoite-induced immunity to mouse malaria. | 1976 | 786705 | |
| plasmodium berghei: heat-treated sporozoite vaccination of mice. | 1976 | 786707 | |
| plasmodium berghei: phagocytic activtiy in two strains of rats. | 1976 | 786708 | |
| influence of rodent malaria on the course of leishmania enriettii infection of hamsters. | plasmodium yoelii infection was established in hamsters, and the effect of this type of malaria on concurrent leishmania enriettii infection was examined. it was found that the course of the l. enriettii infection was affected by p. yoelii and that this effect depended on the relative timing of the two infections. a chronic malarial infection with plasmodium berghei was also established in hamsters, and this was found to affect the course of a concurrent l. enriettii infection in a similar manne ... | 1976 | 786886 |
| sustained release of an antimalarial drug using a copolymer of glycolic/lactic acid. | 1976 | 787714 | |
| viruslike particles in malaria parasites. | the ultrastructural appearance of viruslike particles in several malaria parasites at different times in sporogony is described in detail. emphasis is placed on particle size, 42 to 52 nm, density and the presence or absence of geometric configuration of particle aggregations in p. berghei ookinetes, and p. gallinaceum early oocysts. this particle appearance is compared with that noted in later oocysts of p. berghei, p. gallinaceum, and p. c. bastianelli and with negatively-stained particles obt ... | 1976 | 778372 |
| new synthesis of substituted pyrrolo[1,2-alpha][1,3]diazepine and its pharmacological activity. | a facile route for the synthesis of the substituted pyrrolo[1,2-alpha][1,3]diazepine nucleus from readily available starting material is reported. the compound was tested for antimalarial activity in mice, antineoplastic activity in mice, acute hypotensive activity in rats and dogs, effect on cholesterol-lipoprotein levels in rats, anti-inflammatory activity in rats, antiviral activity in mice, cns depressant or stimulant activity in mice, diuretic activity in fasted rats, and antidiabetic activ ... | 1976 | 778377 |
| synthesis and antimalarial activity of dibenz[c, e]azepine derivatives. | a series of 6-alkyl-2,10-bis(trifluoromethyl)-5h-dibenz-[c,e]azepines were synthesized via a condensation reaction between 5,5'-bis(trifluoromethyl)-2,2'-diformylbiphenyl and the appropriate amine. these compounds were screened for antimalarial activity and were found to be inactive. | 1976 | 778378 |
| antibody-induced ultrastructural changes of malarial sporozoites. | immunization with irradiated sporozoites produces a considerable degree protection against rodent, simian, and human malaria. this protection is in part antibody mediated. antibodies neutralize sporozoites (sna), i.e. abolish their infectivity, and cause, in vitro, the formation of a thread-like precipitate on the parasites (csp reaction). the present study was undertaken to characterize the ultrastructural aspects of antibody-sporozoite interaction. | 1976 | 815435 |
| complement alterations in rodent malaria. | in the course of rodent malaria, the ability of mouse serum to release immune complexes from lymphocytes (complex-release, or cra), a complement dependent function, becomes profoundly altered. these alterations occur in parallel with changes in the serum levels of the third complement component (c3). a transitory but significant increase in cra and c3 was noticed during the first 3 days after blood-induced plasmodium berghei infection. this was followed by a progressive decrease in cra, which wa ... | 1976 | 816212 |
| effect of vitamin a and undernutrition on the susceptibility of rodents to a malarial parasite plasmodium berghei. | the ability of vitamin a deficient rats to resist infection with p. berghei was investigated. when 10 x 10(6) erythrocytes bearing the parasite/100 g body weight were given to the vitamin a protein energy undernourished rats, parasitemia developed in these animals at a faster pace than the controls. a high number (60% to 95%) of red blood cells (rbc) carrying the parasite were noticeable within 6 to 7 days after infection, at which time most animals in this group died. the pair-fed controls (pro ... | 1976 | 818347 |
| synthesis of 5-substituted aminomethyluracils via the mannich reaction. | an extension of the mannich reaction, in which aminomethylation of the five position of uracil, is reported. thus, primary and secondary alkylamines and primary aromatic amines containing ring-activating groups led to the title compounds 3-10. compound 11 in which the aromatic ring contains the ring-deactivating nitro group was synthesized in an alternative way. all compounds were characterized by their elemental and spectral properties. | 1976 | 765460 |
| protection of mice against babesia and plasmodium with bcg. | 1976 | 765838 | |
| cross reactivity between anaplasma marginale and two plasmodium species as demonstrated by passive hemagglutination. | two types of antigens were prepared from each of 3 partially purified preparations of anaplasma marginale, plasmodium lophurae, and p berghei. hemagglutination tests were conducted with homologous serums to detect antigenic relationships between these organisms. serums were also absorbed with both homologous and heterologous antigen preparations. cross reactivity between these organisms was observed. | 1976 | 779540 |
| a comparison of methods used for the removal of white cells from malaria-infected blood. | 1976 | 779686 | |
| the reactivity of spleen cells from malarious rats to non-specific mitogens. | the reaction of spleen cells from rats infected with plasmodium berghei to non-specific mitogens has been measured. the cells have been stimulated in vitro by phytohaemagglutinin, concanavalin-a and by bacterial lypopolysaccharide. in addition the release of lymphocyte activating factor (laf) by splenic macrophages has been assayed using a heterologous thymocyte culture. the reactivity of spleen lymphocytes from malarious rats is severly affected. the cells do not react either to the t cell-spec ... | 1976 | 780016 |
| plasmodium berghei: adaptation of a mouse-adapted strain to the mongolian jird (meriones unguiculatus); infectivity and immunogenicity. | 1976 | 780117 | |
| plasmodium berghei: development of resistance to clindamycin and minocycline in mice. | 1976 | 780118 | |
| plasmodium berghei: phase contrast and electron microscopical evidence that certain antimalarials can both inhibit and reverse pigment clumping caused by chloroquine. | 1976 | 780119 | |
| plasmodium berghei: combining folic acid antagonists for potentiation against malaria infections in mice. | 1976 | 780121 | |
| t and b cell population changes in young and in adult rats infected with plasmodium berghei. | malaria infection in young rats is characterized by high parasitemia, severe anemia, and death. parasitemia is lower in older rats, and the rats usually survive. this study was designed to investigate the immunological basis of this difference. t cell numbers in the thymuses and spleens of young (4 weeks old) and in adult (18 weeks old) infected and control rats were determined by killing with anti-theta serum and complement. the number of complement receptor lymphocytes (b cells) in spleens was ... | 1976 | 780272 |
| adoptive transfer of immunity to plasmodium berghei with immune t and b lymphocytes. | immunity to malarial infection may be transferred with immune lymphocytes. this study was designed to determine which lymphocyte type is responsible for the adoptive transfer of immunity to malarial infection. in one set of experiments, the ability of immune t and b lymphocytes, separated by passage through nylon-wool columns, to transfer immunity to infection was determined. in another experiment, the effect of killing t lymphocytes with anti-theta serum on the transfer of immunity was determin ... | 1976 | 780273 |
| antimalarials. 3. 1,2,4-triazines. | the syntheses of a number of substituted 1,2,4-triazines as potential antimalarials are described. the structural requirements for antimalarial activity are discussed with reference to the substituents of a phenyl group in the 6 position and amino groups at the 3 and 5 positions. of the compounds tested, 2,5, and 7 produced cures in mice infected with plasmodium berghei. compounds 2(3,5-diamino-6-(4-trifluoromethylphenyl)-1,2,4-triazine),3,5,8,12,and 37 produced cures in chicks infected with pla ... | 1976 | 781244 |
| synthesis, antimalarial activity, and phototoxicity of some benzo(h)quinoline-4-methanols. | nine alpha-dibutylaminomethylbenzo[h]quinoline-4-methanols were synthesized from the corresponding 1-amino-naphthalenes by the following sequence: 1-aminonaphthalene leads to 1h-benz[g]indole-2,3-dione leads to benzo[h]quinoline-4-carboxylic acid leads to acid chloride leads to bromomethyl ketone leads to epoxide leads to benzo[h]quinoline-4-methanol. several acid chlorides substituted in the 3 position reacted incompletely with ethereal diazomethane but were efficiently converted, without isola ... | 1976 | 781245 |
| antimalarials. 9. methylthio- and methylsulfonyl-substituted 9-phenanthrenemethanols. | nine di- and trisubstituted 9-phenanthrenemethanols bearing methylthio and methylfulfonyl substituents in the 2 and/or 6 positions of the phenanthrene nucleus were prepared and screened for antimalarial activity against plasmodium berghei in mice. six of the nine compounds were curative at or below 160 mg/kg. the most active structures contained a methylthio substituent in combination with two chlorine atoms. | 1976 | 781249 |
| the plasmodium berghei-infection in isogenic f1 (c57b1 x dba)- mice. iii. neonatal thymectomy and cell transfer experiments. | in neonatally thymectomized f1(c57bl x dba)-mice the course of an infection with plasmodium berghei, strain k 173, was unaltered if compared with the course in normal animals. no shortening of the survival time was observed. cell transfer experiments were carried out. in numerous trials it was not possible to convey the protective immunity of immune animals to non-immune animals by the transfer of lymphoid cells. if an acquired immunity was destroyed by heavy x-irradiation it could be restored b ... | 1976 | 781956 |
| malaria: macrophage migration inhibition factor (mif). | 1976 | 768434 | |
| malaria: decreased survival of transfused normal erythrocytes in infected rats. | 1976 | 768435 | |
| antimalarials. 8. synthesis of amino ethers as candidate antimalarials. | based upon the antimalarial activities demonstrated by compounds i and ii a series of amino ethers represented by structures iii-vi was synthesized. these structures incorporated several modifications of compound ii. the compounds prepared displayed no activity in either the rane p. berghei mouse screen or the rane p. gallinaceum sporozoite-induced chick test. | 1976 | 768473 |
| antimalarials. 11. 2-vinylogs of substituted 2-aryl-4-quinoline amino alcohols. | 3-(p-chlorobenzylidene)-5, 7-dimethyl-2, 3-dihydro-1h-cyclopenta[b]quinoline-9-(di-n-butylaminomethyl)methanol and 2-[beta-(p-chlorostyryl)]-6, 8-dimethylquinoline-4-(di-n-butylaminomethyl)methanol were synthesized from 6, -8-dimethyl-4-hydroxycarbostyril by 3, 3-dichlorination, dimethoxylation th the 3-ketal, basic hydrolysis to the glyoxal acetal, pfitzinger condensation with cylopentanone or acetone to the 2, 3-trimethylene or 2-methylquinoline, condensation with p-clphcho at the 2-methylene ... | 1976 | 768474 |
| the plasmodium berghei-infection in isogenic f1(c57b1 x dba)-mice. ii. antibodies and antigens in the serum. | using the fluorescent antibody technique it was possible to demonstrate antibodies in the sera of f1(c57b1 x dba)-mice already during the first week of infection with plasmodium berghei, strain k 173. these antibodies reached high titers during the second and third week, but, nevertheless, the animals died from the infection. coincidently with the fat-antibodies plasmodial antigens could be found in the sera of infected mice. the numbers of these antigens increased in the course of the infection ... | 1976 | 769269 |
| plasmodium berghei: characteristics of a selected population of small free blood stage parasites. | the characteristics of a selected population of small blood stage parasites obtained by differential centrifugation of a population of p. berghei parasites freed by continuous flow sonication are described. about 10% of these free parasites are merozoites, many others are transitional forms having some merozoite characteristics. the parasite preparations are infectious and sufficiently resistant to incubation at 37 degrees c to be useful experimentally. disc gel electrophoresis analysis indicate ... | 1976 | 769270 |
| a temporal relationship between reticuloendothelial system phagocytic alterations and antibody responses in mice infected with plasmodium berghei (nyu-2 strain). | malaria-induced immunosuppression has been demonstrated in humans and experimental animals. the suppressed immune response has been suggested to be primarily humoral and not cellular in nature, since classical lymphocytic cell-mediated responses have been reported to be normal. since previous results have demonstrated that an impairment in macrophage antigen processing may be a contributing factor in malaria-induced immunosuppression, the present studies were conducted to determine if the macrop ... | 1976 | 769577 |
| adoptive transfer of immunity to plasmodium berghei by a population of immune rat spleen cells resistant to cyclophosphamide. | 1976 | 770355 | |
| nonspecific resistance to infection induced in mice by a water-soluble adjuvant derived from mycobacterium smegmatis. | the effect of a nontoxic, water-soluble adjuvant (neo-wsa) from delipidated cells of mycobacterium smegmatis on the susceptibility of mice to infection with four challenge organisms was studied. an intravenous dose of 1 mg of neo-wsa per mouse 24 hr before challenge enhanced resistance to infection with a fungus (candida albicans), a gram-negative bacterium (klebsiella pneumoniae), and a gram-positive bacterium (streptococcus pneumoniae). protection by neo-wsa was not significant when the mice w ... | 1976 | 772130 |
| plasmodium berghei berghei: irradiated sporozoites of the anka strain as immunizing antigens in mice. | 1976 | 773654 | |
| plasmodium berghei: i. immunochemical properties of fractions of a soluble extract. | 1976 | 773655 | |
| plasmodium berghei: ii. immunobiological properties of fractions of a soluble extract. | 1976 | 773656 | |
| an in vitro assay for t cell immunity to malaria in mice. | after infection with a nonlethal strain of murine malaria (17xnl plasmodium berghei yoelli), balb/c mice are then resistant to a lethal strain (17xl p.b. yoelli). balb/c mice were infected with 17xnl, anc challenged 3 weeks later, after clearing their parasitemias, with 17xl. three weeks thereafter, spleen cells from such immune animals were used to define an early peaking t-dependent (anti-theta sensitive) antigen-specific proliferative response when incubated in vitro with 17xl infected rbc, o ... | 1976 | 774978 |
| antimalarials v: aminobenzothiazoles. | four mono- and dialkylated 4-aminobenzothiazoles (vii-x) were prepared as analogs of potent causal prophylactic drugs in the 8-aminoquinoline series. compounds vii and viii were toxic at 80 mg/kg in the chick; ix was inactive at 640 mg/kg. in a sporozoite-induced mouse test system, x was inactive at 30 mg/kg and toxic at 480 mg/kg. none of the compounds was active as a suppressive drug. | 1976 | 775054 |
| antimalarial activity of some novel derivatives of 2,4-diamino-5(p-chlorophenyl)-6-ethylpyrimidine (pyrimethamine). | thirteen new analogs of 2,4-diamino-5(p-chlorophenyl)-6-ethylpyrimidine (daraprim, pyrimethamine) in which the alph position of the 6-ethyl substituent was modified were prepared. the respective oxygens analogs (ketals, ketone, alcohol), the dimethyl hydrazone, and the nitrone displayed activities in the range of 1/4 to 1/16 that of pyrimethamine toward plasmodium berghei in mice. the therapeutic ratios of some of these compounds may be slightly better than that of pyrimethamine. | 1976 | 775088 |
| the chemotherapy of rodent malaria, xxiv. the blood schizontocidal action of erythromycin upon plasmodium berghei. | erythromycin inhibits chloroquine-induced pigment clumping in plasmodium berghei in vitro. the drug was therefore tested against infections of p. berghei in mice and was found to be active at non-toxic doses. given orally, the stearate salt was more effective than the base, but subcutaneously the base was more effective than the stearate. erythromycin potentiated the action of chloroquine against two chloroquine-resistant strains of rodent malaria, the mildly resistant ns, and the highly resista ... | 1976 | 788656 |
| the chemotherapy of rodent malaria, xxv. antimalarial activity of wr 122,455 (a 9-phenanthrenemethanol) in vivo and in vitro. | wr 122,455, 3,6-bis-(trifluoromethyl)-alpha-(2-piperidinyl)-9-phenanthrenemethanol hcl, suppresses infection with drug-sensitive plasmodium berghei n strain in mice. it acts rapidly and affects all the stages of the asexual intraerythrocytic parasites, the effective dose levels being about three times those of chloroquine and one-twelfth to one-fifteenth those of quinine. under the influence of wr 122,455 haemozoin seems to disappear from the affected parasites following an initial coarsening of ... | 1976 | 788657 |
| the chemotherapy of rodent malaria, xxvi. the potential value of wr 122,455 (a 9-phenanthrenemethanol) against drug-resistant malaria parasites. | the phenanthrenemethanol compound wr 122,455 is an effective blood schizontocide against lines of plasmodium berghei that are highly resistant to primaquine, sulphonamides, pyrimethamine and cycloguanil. it is also active against the ns line that is moderately resistant to chloroquine. wr 122,455 is inactive against the rc line which is highly resistant to chloroquine. resistance to wr 122,455 is fairly readily developed by the drug-sensitive n strain of p. berghei, using a relapse technique. r ... | 1976 | 788658 |
| studies on azadiracta indica in malaria [proceedings]. | 1976 | 788819 | |
| plasmodium berghei: osmotic fragility of malaria parasites and mouse host erythrocytes. | 1976 | 789104 | |
| cultivation of the erythrocytic stages of plasmodium berghei in primary bone marrow cells. | cultures of primary bone marrow cells, obtained from the tibiae and femora of hamsters (hbm), mice (mbm), or rats (rbm) were inoculated with red cells infected with plasmodium berghei, p. vinckei vinckei, or p. knowlesi. merozoites, rings, trophozoites, schizonts and a few gametocytes were seen in hbm and mbm cells inoculated with p. berghe-infected red cells. at 1 to 2 or 3 days after inoculation in hbm and mbm, the number of intracellular asexual stages decreased slightly or remained the same, ... | 1976 | 789846 |
| schizont-infected cell enrichment in rodent malaria. | mouse erythrocytes parasitized with plasmodium berghei or plasmodium yoelii were separated by ultracentrifugation using preformed isodensity gradients of the discontinuous type. three fractions were obtained following centrifugation, the upper of which contained greater than 90% of all schizont-infected cells added to the gradient. the gradient material, stractan ii, is an arabinogalactan polysaccharide and appears to yield results similar to those available using gradients of bovine serum album ... | 1976 | 789847 |
| stimulation of resistance in mice to sporozoite-induced plasmodium berghei malaria by injections of avian exoerythrocytic forms. | mice received a series of injections of formalin-killed merozoites (fkm) of exoerythrocytic stages of plasmodium fallax prior to challenge with sporozoites of p. berghei. in one study 4 of 16 fkm-immunized mice never exhibited parasitized erythrocytes after 2 challenges of 10(4) p. berghei sporozoites each, while all control animals died with high parasitemias. fkm-immunized mice were as susceptible as control mice to infections initiated with parasitized erythrocytes. in a second study, 14 of 1 ... | 1976 | 789848 |
| synthesis and properties of mesoionic pyrimido[1,2-b-a1pyridazine-2,4-diones and mesoionic pyridazino[2,3-a-a1-s-trizine-2,4-diones: mesoionic analogs structurally related to fervenulin. | derivatives of two new and unusual classes of heterocycles, possessing structural similarities to the broad spectrum antibiotic fervenulin, were synthesized and examined for in vitro antimicrobial activity. only three of 17 mesoionic pyrimido[1,2-b]pyridazine-2,4-diones exhibited evidence of antimicrobial activity while seven of eight mesoionic pyridazino[2,3-a]-s-triazine-2,4-diones were active against one or more microorganisms. susceptibility toward attack by nucleophiles of both mesoionic py ... | 1976 | 789854 |
| interaction between trypanosoma brucei and plasmodium berghei in concurrent infections in mice. | in conccurrent infection of trypanosoma brucei rhodesiense and plasmodium berghei yoelii in mice, potentiation of one parasite by the other was observed, especially the malaria by the trypanosome infection. the effect appeared early in the infection. it is suggested that the mutual potentiation of the two infections was probably due to immuno-suppression which both organisms are capable of inducing in the host. | 1976 | 789909 |
| [transfusional serology of malaria by an indirect immunofluorescence test using the plasmodium berghei antigen]. | 1976 | 790519 | |
| physiological and morphological characters in two pyrimethamine-resistant lines of plasmodium berghei sp11 after cryopreservation. | the authors describe the characters in two pyrimethamine-resistant lines of plasmodium berghei berghei sp 11-rr after long storage at very low temperatures. in one case the line had maintained its original virulence but lost its resistance to pyrimethamine. gametocytogenesis increased and cyclical transmission was successful. furthermore, parasites crossed the blood-brain barrier and provoked cerebral malaria. in the other case no physiological changes could be detected. the authors conclude tha ... | 1976 | 790672 |
| interaction between protective antibodies and malaria parasites (plasmodium berghei): involvement of low avidity antibodies. | free plasmodium parasites were incubated with a standardized amount of immune serum in a small volume of fluid or a larger one. when these parasites were tested for infectivity in and in vivo test system the parasites incubated in the larger volume of fluid were more infective. other aliquots of free p. berghei parasites were incubated with a standaridzed amount of immune serum and then reincubated with or without dilution of the suspending fluid. those parasites reincubated after dilution were ... | 1976 | 790706 |
| cyclophosphamide pretreatment and protection against malaria. | mice pretreated with cyclophosphamide were able to overcome infection from a lethal malarial strain. the development of resistance was preceded by increased hypersensitivity to malarial antigens. hypersensitivity was demonstrable by a delayed footpad swelling technique. | 1976 | 791863 |
| t cells and protective immunity to plasmodium berghei in rats. | experiments were carried out in which unfractionated spleen cells, and t lymphocyte subpopulations characterized by certain experimental criteria, were isolated at various times from rats infected with plasmodium berghei. by adoptive transfer it was shown that unfractionated spleen cells, and t cells alone, could transfer protection to syngenic recipients as early as 11 days after infection of the cell donors. the protection conferred by t cells increased with the duration of the infection in th ... | 1976 | 791865 |
| cultivation of the erythrocytic stages of plasmodium berghei in leydig cell tumor cultures. | twelve different established cell-lines were used in attempts to cultivate the erythrocytic stages of plasmodium berghei, p. vinckei vinckei, p. coatneyi or p. knowlesi. intracellular parasites were seen in only mouse leydig cell testicular tumor (lct) cultures inoculated with red cells infected with p. berghei. intracellular parasites were present at 15 to 96 h after inoculation, being most numerous at 36 h. most intracellular stages were rings, trophozoites, schizonts and merozoites; gametocyt ... | 1976 | 793226 |
| [comparative morphology by optical and scanning electron microscopy of erythrocytes from mice infected with plasmodium berghei]. | 1976 | 793494 | |
| a comparison of two different methods for the selection of primaquine resistance in plasmodium berghei berghei. | 1976 | 793547 | |
| plasmodium berghei: deep vascular sequestration of young forms in the heart and kidney of the white rat. | 1976 | 793548 | |
| malarial immunodepression in vitro: adherent spleen cells are functionally defective as accessory cells in the response to horse erythrocytes. | the basis for the depressed response of malarial infected mice to horse red blood cells (hrbc) has been studied in vitro. results presented show that the adherent spleen cells from infected mice (a) are defective in their ability to allow nonadherent spleen cells of both normal and infected mice to respond to hrbc whereas a response does occur with adherent spleen cells from normal mice (b) do not suppress the response of unfractionated spleen cells from normal mice to hrbc (c) contain phagocyti ... | 1976 | 793851 |
| surface properties of extracellular malaria parasites: electrophoretic and lectin-binding characteristics. | the surface charge and lectin-binding capacity of isolated malaria parasites and host erythrocytes were analyzed and compared by chromatographic, electrophoretic, and cytochemical methods. results indicated that at physiological ph values both freshly prepared and glutaraldehyde-fixed parasites and erythrocytes possess a net negative surface charge. both cell types were strongly bound to cation-exchange resins and underwent cathode-directed electrophoretic migration. the isoelectric points for e ... | 1976 | 793992 |
| studies on plasmodium ookinetes. 1. isolation and concentration from mosquito midguts. | in a method for isolating a relatively clean suspension of concentrated plasmodium berghei ookinetes from infected midguts of anopheles stephensi at appropriate times after the infective blood meal, the ookinetes are freed from the midguts by enzymatic digestion, and then concentrated by means of a bsa/renografin gradient. the mean number of ookinetes recovered/midgut was 152. more than 95% of the recovered ookinetes were viable by the criteria of motility, incorporation of adenosine and leucine ... | 1976 | 794460 |
| [chemotherapeutically active nitro compounds. 2nd communication: nitrodiphenyl sulfones (author's transl)]. | a number of new 4-nitro-4'-amino-diphenyl sulfones and related compounds were prepared and investigated as to their therapeutic activity. they showed a good systemic activity against tubercle bacilli (m. bovis, nmri mouse) and plasmodia (p. berghei, nmri mouse). the test results reveal that the 4-nitro-4'-amino-diphenyl sulfones possess a spectrum of activity similar to that of diamino-diphenyl sulfone (dds). it is assumed that 4-nitro-4'-amino-diphenyl sulfones in vivo are converted into dds de ... | 1976 | 795435 |
| mouse malaria nephropathy. | mice were infected with 1x 107 plasmodium berghei yoelii parasites intraperitoneally. circulating parasite, malaria antibody and c3 concentrations were measures: parasitaemia and hypocomplementaemia were transient, but the antibody response was persistent. animals were sacrificed at intervals and their kidneys examined: a glomerulonephritis associates with predominantly mesangial deposits of c3, igg1, igm and some iga always developed after 7 days and persisted for up to 6 mth. malaria antigen a ... | 1976 | 796419 |
| suppression of malaria infection by oxidant-sensitive host erythrocytes. | 1976 | 796730 | |
| [absence of transplacental passage in congenital trypanosomiasis in mice with trypanosoma equiperdum. comparison with results obtained in congenital malaria (p.b. berghei) in the same animal]. | 1976 | 797328 | |
| abnormal red cells in the peripheral blood of malarian mouse. | 1976 | 798563 | |
| preliminary studies of artificial immunization of rats against plasmodium berghei and adoptive transfer of this immunity by splenic t and t + b cells. | protective t lymphocyte and t+b lymphocyte responses in rats artificially immunized against p. berghei have been demonstrated by adoptive transfer. the techniques used could be developed for detailed analysis of protective lymphocyte responses generated by various methods of immunization, and their relationship to immunity. | 1976 | 798635 |
| vaccine against malaria in rodents--a preliminary communication. | 1976 | 798726 |