Publications

[inhibition of antigenic competition by immunostimulants].	the diminution of immune response against srbc induced in mice, by a prior injection of hrbc was counteracted by addition of certain immunostimulants to srbc. the intensity of inhibition of antigenic competition was related to the quantity of immunostimulant added to srbc. some immunostimulants (b. abortus, lipopolysaccharide) were more active than others (c. parvum, poly i : c). to inhibit antigenic competition immunostimulant had to be injected after or in mixture with srbc never before.	1975	56240
evidence for an allotypic marker on canine immunoglobulin.		1975	53927
letter: side-effects of intravenous corynebacterium parvum.		1975	53755
ultrastructure of human sebaceous follicles and comedones following treatment with vitamin a acid.	ultrastructural findings in normal human sebaceous follicles, of comedones from acne patients, and from comedones during topical treatment with vitamin a acid (vaa) are described. in normal human sebaceous follicles, the two segments of the infundibulum-the acroinfundibulum and the infrainfundibulum-show differing ultramorphological patterns of keratinization. the incomplete horny layer of the infrainfundibulum is physiological and seems to be necessary for its normal function. on the other hand ...	1975	130781
letter: toxicity of intravenous corynebacterium parvum.		1975	53574
letter: immunological control of cancer.		1975	48154
letter: adjuvant contact suppression of experimental tumours.		1975	48032
letter: corynebacterium parvum and anaesthetics.		1975	47551
letter: anaerobic corynebacteria and anaesthetics.		1975	47129
[effect of a polysan preparation for the treatment of acne on the growth of corynebacterium acnes and staphylococcus pyogenes aureus].		1975	125629
quantification of bacteria in isolated pilosebaceous follicles in normal skin.	a technique for quantitating bacteria in isolated pilosebaceous follicles is described. this involves microdissection of the follicles from biopsies of skin, using the method of chemical pretreatment of skin to facilitate the separation of the epidermis and epidermal appendages from the dermis. the aerobic cocci and anaerobic diphtheroids in pilosebaceous follicles in 66 biopsies of scalp and 48 biopsies of skin of the upper back were quantitated using this technique. on the back, aerobic staphy ...	1975	127814
ad hoc committee report: systemic antibiotics for treatment of acne vulgaris: efficacy and safety.		1975	128326
scientific approach to the treatment of acne vulgaris.		1975	129306
lipolytic activity of microorganisms in acne vulgaris.		1975	129776
effect of pretreatment with mycobacterium bovis (strain bcg) and immune syphilitic serum on rabbit resistance to treponema pallidum.	stimulation of the rabbit reticuloendothelial system with viable mycobacterium bovis (strain bcg), and other agents, had no effect on the development of syphilitic lesions after intradermal or intravenous inoculation with graded doses of treponema pallidum (virulent nichol's strain; mean infective doses less than 10). the simultaneous administration of immune syphilitic rabbit serum retarded the development of lesions, but this appeared to be due solely to the immune serum, suggesting no synergi ...	1975	172450
suppression of cell-mediated tumour immunity by corynebacterium parvum.		1975	170531
histological and combined chemoimmunostimulation therapy studies against a murine leukemia.	a graffi murine leukemia was utilized as a model system to investigate the effect of chemoimmunostimulation therapy. subcutaneous inoculation of approximately 1.0 times 10(6) tumor cells resulted in a rapidly growing tumor at the site of inoculation and subsequent development of splenomegaly and lymphoadenopathy. all animals succumbed to the leukemia within 24 to 30 days. treatment of diseased animals with two courses of cytoxan over a 2-week period resulted in a remission period of approximatel ...	1975	170212
[first clinical trials of treatment of primary liver cancer with immunostimulating agents administered by systemic or intratumoral route].		1975	170046
analysis of lipid composition of isolated human sebaceous gland homogenates after incubation with cutaneous bacteria. thin-layer chromatography.	the effects of specific species of skin bacteria on human sebaceous gland lipids in vitro were analyzed. isolated dissected sebaceous glands were pooled, homogenized, and sterilized, then incorporated into peptone-yeast extract medium and used as substrate for growth of propionibacterium acnes, p. granulosum, and staphylococcus epidermidis subgroup ii. the sebaceous lipids were analyzed by thin-layer chromatography before and after bacterial growth. the most striking effect of bacteria on sebace ...	1975	237966
effect of corynebacterium acnes on interferon production in mouse peritoneal exudate cells.	corynebacterium acnes, an organism closely related to c. parvum, has been recognized to have a striking effect on the reticuloendothelial system, as well as on both humoral and cellular immunity. in mice previously exposed to c. acnes, serum interferon levels induced by injection of newcastle disease virus (ndv), chikungunya virus (cv), and polyinosinic-polycytidylic acid are suppressed. when peritoneal macrophages and lymphocytes from animals exposed to c. acnes were cultivated in vitro, their ...	1975	234914
[oral antigen treatment (oral vaccination) in acne diseases].		1975	236624
quantitative microbiology of the scalp in non-dandruff, dandruff, and seborrheic dermatitis.	the composition of the scalp microflora was assessed quantitatively in normal individuals and in patients with dandruff and seborrheic dermatitis, disorders characterized by increasing scaling. three organisms were constantly found: (1) pityrosporum, (2) aerobic cocci, and (3) corynebacterium acnes. pityrosporum (mainly pityrosporum ovale) made up 46% of the total microflora in normals, 74% in dandruff, and 83% in seborvheic dermatitis. the geometric mean number of organisms per cm-2 in non-dand ...	1975	237965
the localization and distribution of gram-positive cocci in normal skin and in lesions of acne vulgaris.	the localization of gram-positive cocci in the normal skin and in the lesions of acne vulgaris was investigated using fluorescein-labeled antiserum raised to gram-positive, coagulase-negative cocci. the cocci were found in 10 of 19 specimens from normal facial skin and in 3 of 11 specimens from the normal skin of the rest of the body. the bacteria were found mostly in the openings of follicles, but in 6 of 10 facial skin specimens, they were also present deeply in the lumina of the dilated sebac ...	1975	239073
phase i study of corynebacterium parvum in patients with solid tumors.	nineteen patients with various solid tumors were treated with corynebacterium parvum for 10 consecutive days at doses ranging from 0.5 to 6 mg/m2. major toxic effects included rigors and cyanosis, hypertension, headache, nausea, and vomiting. toxicity was maximal during the first 3 days of treatment and decreased or even disappeared when, on subsequent days, increasing doses of the vaccine were given. objective tumor regressions were observed in four patients.	1975	769953
proceedings: influence of cornyebacterium parvum and of anti-lymphocyte serum (als) on bone marrow transplantation in small rodents.		1975	766804
chemical and immunological studies on the cell walls of propionibacterium acnes strain c7 and corynebacterium parvum atcc 11829.	the chemical and immunological properties of the cell walls prepared from the cells of anaerobic coryneforms, propionibacterium acnes c7 and corynebacterium parvum atcc 11829, were partially investigated. the cell walls prepared from p. acnes c7 and c. parvum atcc 11829 were composed of fatty acids, polysaccharides consisting glucose, galactose and mannose and mucopeptides consisting mainly of alanine, glutamic acid, alpha, epsilon-diaminopimelic acid, glycine, muramic acid and glucosamine. as t ...	1975	811835
effect of corynebacterium parvum on the course of a listeria monocytogenes infection in normal and congenitally athymic (nude) mice.	spleen counts of listeria monocytogenes in normal mice challenged with various numbers of organisms were generally lower in mice injected 3 days previously with killed corynebacterium parvum. this increased resistance was unexpected since c. parvum generally inhibits t cell-mediated immunity, the functional immunity against listeria being t cell-dependent. the inhibitory effect on t cells seemed to be compensated by the stimulatory effect of c. parvum on macrophages. therefore, the experiments w ...	1975	808049
level of redox potential as a possible contributing influence in the pathogenicity of oral anaerobes.	dental plaque anaerobes may be associated with the etiology of periodontal disease. this has created an interest in the potential pathogenicity of oral anaerobes. we compared the metabolic activity of anaerobic corynebacteria (c. parvum, c. anaerobium) and corresponding aerobic species (c. diphtheriae, c. xerosis). the anaerobes exhibited lower levels of rna synthesis, ranging from 5 to 10 fold over the aerobes. we further examined these anaerobes, plus actinomyces naeslundi n16 (isolated from t ...	1975	816253
mitogenicity of corynebacterium parvum for mouse lymphocytes.	corynebacterium parvum, a powerful in vivo immunostimulant, is shown to stimulate lymphocyte proliferation in vitro. c. parvum is mitogenic for b lymphocytes and does not stimulate t cells. the mitogenicity is dependent on the presence of macrophages. c. diphtheriae and another strain of c. parvum, both of which are devoid of adjuvant, res stimulation, and tumour-inhibiting activities in vivo are nevertheless mitogenic. a lipid-free fraction from c. parvum, which retains in vivo immunostimulator ...	1975	817854
potentiation of the tumor-specific immune response by corynebacterium parvum.	strong, specific, cell-mediated antitumor immunity resulted from the sc injection into mice of corynebacterium parvum (cp) mixed with irradiated cells from mastocytoma p815 (ma), whereas injection of irradiated ma alone was without effect. maximum immunity was achieved with small doses of cp, and the injection sites of cp and irradiated ma did not need to be coincident but required common lymphoid drainage for immunity to result. the process was largely t-cell dependent but not dependent on the ...	1975	808637
[effect of immunostimulation by corynebacterium parvum on evolution and metastatic dissemination of lewis's tumor in mouse c57bl/6 mice].	treatment with corynebacterium parvum (c. parvum) produces a significant prolongation of survival time of lewis tumor bearing animals and reduces strikingly the incidence of pulmonary metastasis in syngeneic c57bl/6 mice. on the other hand, treatment with imuran, a known immunodepressive agent, reduces survival time and facilitates metastatic dissemination in the same model.	1975	809167
dichotomy between macrophage activation and degree of protection against listeria monocytogenes and toxoplasma gondii in mice stimulated with corynebacterium parvum.	in vivo and in vitro experiments were conducted to determine the effect of corynebacterium parvum treatment of mice on resistance of listeria monocytogenes and toxoplasma gondii. intravenous immunization with c. parvum conferred transient protection against intravenous challenge with listeria or an avirulent strain of toxoplasma but did not protect against a virulent strain of toxoplasma. compared with the level of protection conferred by c. parvum, a higher degree of resistance was noted when m ...	1975	811563
the effect of gold salts on tumour immunity and its stimulation by corynebacterium parvum.	the anti-inflammatory agent sodium aurothiomalate appears to act upon mononuclear phagocytes, inhibiting their lysosomal enzyme activity. evidence is presented that gold salts can increase the number of lung tumour nodules that develop following intravenous injection of tumour cells and pretreatment can enhance the take of a subcutaneous tumour inoculum. in contrast, they do not affect the later growth of tumour. gold salts can also suppress the action of systemically administered c. parvum in i ...	1975	813755
enhancement of resistance and suppression of immunization against experimental trypanosoma cruzi infection by corynebacterium parvum.	intravenous but not intraperitoneal injection of killed corynebacterium parvum either before or after intraperitoneal infection with the highly reticulotropic tulahuén strain of trypanosoma cruzi produced enhanced resistance against the infection in mice. in contrast, c. parvum had no effect when the infection was caused with the predominately myotropic y strain of t. cruzi. c. parvum given intravenously before immunization with killed culture forms of the y strain parasite consistently diminish ...	1975	811568
[management of acute leukemias and linphosarcomas with active immunotherapy (author's transl)].		1975	1056311
bacteriology of normal and infected conjunctiva.	the conjunctivas of 273 inflamed eyes were cultured by both aerobic and anaerobic techniques. isolations were obtained from 267 (97.8%) of the eyes. aerobic organisms were isolated from 237 (86.8%) of the conjunctivas. staphylococcus aureus from 63 (23.1%) of the diseased eyes was the aerobic pathogen most often isolated. anaerobic bacteria were isolated from 172 (63.0%) of the conjunctivas. propionibacterium acnes was isolated from 126 (46.2%) of the conjunctivas, and peptostreptococcus species ...	1975	1176598
new experimental and clinical data on leukaemia immunotherapy.	the present results of our treatment of acute lymphoid leukaemia patients are summarized: 7 out of 20 randomized patients given active immunotherapy after chemoradiotherapy are still in complete remission after periods varying from seven to ten years (compared to none in the control group). the actuarial results on 100 patients show remission and survival curves presenting a plateau between three and five years for a certain percentage, suggesting a possible cure. several parameters studied in 2 ...	1975	1060146
enhancement by drugs of metastatic lung nodule formation after intravenous tumour cell injection.	in studies on a model of induced pulmonary metastasis in mice a tumour host system was analysed which was not affected by immunogenicity of the tumour for the host; neither intensive immunosuppression nor immunization caused a significant change in the quantity of pulmonary metastatic nodules. in contrast the application of cytostatic drugs and of corynebacterium parvum could modify the pulmonary resistance to the formation of tumour nodules by a factor greater than 100 in either direction. this ...	1975	1056314
mechanisms of macrophage activation by corynebacterium parvum. ii. in vivo experiments.		1975	1079165
daily intravenous infusions of corynebacterium parvum in twenty patients with disseminated cancer: a preliminary report of clinical and biologic findings.	twenty terminally ill patients with various disseminated tumors were treated with daily iv infusions of corynebacterium parvum given alone at doses of 4 mg/day, 5 days/week, for 4-16 weeks. in 8 patients (40%), the lesions partially regressed to less than 50% of their original size. another patient who did not improve with c. parvum therapy had a complete remission after the first course of chemotherapy. skin tests, total leukocyte counts, and t- and b-cell counts revealed variable and unpredict ...	1975	1080521
effect of local injection of corynebacterium parvum on the growth of a murine fibrosarcoma.	local injection (i.e. injection at the site of tumour inoculation) of strains of c. parvum which have a significant anti-tumour effect when given systemically (i.e. intravenously or, in the case of subcutaneous tumour transplant, intraperitoneally) strongly inhibits the growth of isogeneic transplants of a fibrosarcoma in intact cba mice but has little or no effect on subcutaneous transplants of the same tumour in t-cell deprived mice. the anti-tumour effect of local injection of c. parvum, unli ...	1975	1080671
active specific immunotherapy of mouse methylcholanthrene induced tumours with corynebacterium parvum and irradiated tumour cells.	the relative efficiency of active nonspecific or specific immunotherapy of developing methylcholanthrene induced fibrosarcomata with c. parvum was compared. for nonspecific immunotherapy, mice were challenged with tumour cells s.c. or i.v., and 2 days later injected i.v. with dilutions of c. parvum. the only significant effect was a retardation of s.c. tumour growth by the highest concentration of c. parvum (350 mug). however, active specific immunotherapy, using mixtures of c. parvum and irradi ...	1975	1082344
cancer immunology.		1975	1135940
osteosarcoma: a reconnaissance.		1975	1091399
effect of corynebacterium parvum on the class and subclass of antibody produced in the response of different strains of mice to sheep erythrocytes.	several strains of mice were injected with sheep erythrocytes (srbc) using c. parvum as adjuvant. the adjuvant effects on the amounts of class and subclass of antibody produced were ranked in the order igg2b greater than igg2a and igm greater than igg1. in addition, these effects were shown to vary depending on the time of administration of c. parvum relative to antigen. c parvum was shown to have no adjuvant effect on the response of congenitally athymic mice when given at the same time as the ...	1975	1092609
rejection of mammary adenocarcinoma cell tumors in dba/2 mice immunocompromised by thymectomy and treatment with antithymocyte serum.	syngeneic mammary adenocarcinoma cells were mixed with killed corynebacterium parvum organisms and were then transplanted subcutaneously into groups of normal and immunocompromised mice. the tumors formed at the site of injection exhibited normal growth for approximately 12 days followed by rapid and lasting rejection in both normal and immunocompromised animals. the control mice were protected against reinjections of 10-4 to 10-8 cells of the same line of tumor cells. the immunocompromised mic ...	1975	1092759
tumor inhibitory properties of anaerobic corynebacteria.		1975	1093294
suppression of the immune response by microorganisms.		1975	1095003
[a study on the nature of corynebacterium acnes (author's transl)].		1975	1099281
[stimulating effect on in vitro cell growth of spleen cells from tumor bearing mice].		1974	4849772
chronic meningitis caused by propionibacterium acnes. a potentially important clinical entity.		1974	4858158
lasting rejection of mammary adenocarcinoma cell tumors in dba-2 mice with intratumor injection of killed corynebacterium parvum.		1974	4810906
the effect of transplanted methylcholanthrene induced fibrosarcomata and corynebacterium parvum on the immune response of cba and a-hej mice to thymus dependent and independent antigens.		1974	4820942
corynebacterium parvum: a synonym for propionibacterium acnes?		1974	4826546
anti-tumour effect in vitro of lymphocytes and macrophages from mice treated with corynebacterium parvum.		1974	4830143
proceedings: immunotherapy of moloney sarcoma virus tumours in mice with corynebacterium parvum.		1974	4832648
increased phagocytic cell activity and anaemia in corynebacterium parvum treated mice.		1974	4835797
letter: methyl-cholanthrene-induced sarcomata in mice after immunisation with corynebacterium parvum plus syngeneic subcellular membrane fractions.		1974	4143365
an overview of acne.		1974	4274207
acne: perspectives.		1974	4274209
the microflora of the face and acne lesions.		1974	4274210
genesis of free fatty acids.		1974	4274211
[investigations of the serological relationship between actinomyces israelii and corynebacterium acnes (author's transl)].		1974	4151213
enhancement and depression of the antibody response in mice caused by corynebacterium parvum.		1974	4157122
[antibiotic sensitivity of corynebacterium acnes].		1974	4276912
[current data on acne juvenilis with reference to the role of corynebacterium acnes].		1974	4277158
a technique for sampling micro-organisms from the pilo-sebaceous ducts.		1974	4213708
the skin microflora in acne vulgaris.		1974	4271839
carriage of corynebacterium acnes in school children in relation to age and race.		1974	4279690
hydrosoluble immunopotentiating substances extraced from corynebacterium parvum.		1974	4217774
properties of an antigenic polysaccharide from corynebacterium parvum.	corynebacterium parvum strain 10390 is an antitumor agent and stimulant of the reticuloendothelial system and produces a soluble antigen towards the end of its growth cycle. this material, which is a cell wall component and can also be released from the organism by acid or alkaline hydrolysis, has been purified. it is an acidic polysaccharide of molecular weight 100,000 to 150,000 and contains galactose, glucose, fucose, n-acetylgalactosamine, n-acetylglucosamine, uronic acids, sialic acids, and ...	1974	4138438
effects of corynebacterium parvum and freund's adjuvants on amphibian antibody responses.		1974	4142047
immunostimulation with bacterial phospholipid extracts.	injection of bacterial phospholipid extracts (ebp) into mice increased their resistance towards a listeria monocytogenes infection. the blood clearance of virulent salmonella typhimurium was enhanced and the degree of clearance correlated with the dose of extract injected. the multiplication of listeria monocytogenes in spleen and liver of mice was inhibited and this inhibition was also correlated with the amount of extract injected. the absence of apparent toxicity in mice, of splenoand hepatom ...	1974	4205595
potential antileprotic agents. 3. inhibition of mycobacterial dihydrofolic reductase by 2,4-diamino-5-methyl-6-alkylquinazolines.		1974	4209923
corynebacterium parvum as a therapeutic antitumor agent in mice. i. systemic effects from intravenous injection.		1974	4213015
corynebacterium parvum as a therapeutic antitumor agent in mice. ii. local injection.		1974	4213016
immunotherapy of cancer: regression of established intradermal tumors after intralesional injection of mycobacterial cell walls attached to oil droplets.		1974	4364736
the normal microbial flora of the skin.		1974	4373839
[the antiviral properties of corynebacterium parvum].		1974	4376977
the effect of a single and repeated administration of corynebacterium parvum on bone marrow macrophage colony production in syngeneic tumor-bearing mice.		1974	4419513
characteristics of the extracellular lipases from corynebacterium acnes and staphylococcus epidermidis.		1974	4276477
[considerations on some cases of acute lymphatic leukemia treated with aspecific active immunotheraphy].		1974	4526571
acne. pathogenesis and treatment.		1974	4278415
tumour growth, phagocytic activity and antibody response in corynebacterium parvum-treated mice.		1974	4549691
the effect of preadministration of corynebacterium parvum on the protection afforded by heat-killed and acetone-killed vaccines against experimental mouse typhoid.	mice given an intraperitoneal injection of 0.5 mg. corynebacterium parvum (dry weight) before vaccination with heat-killed (hk) or acetone-killed (ak) salmonella typhimurium vaccine and later challenged intraperitoneally with s. typhimurium strain 1566, showed a statistically significant increase in mortality when compared with mice that had received only c. parvum but no vaccine. they also showed a higher mortality rate than mice receiving only hk or ak vaccine or mice that had received no vacc ...	1974	4593737
corynebacterium acnes and other anaerobic diphtheroids from human skin.		1974	4278837
[an immunobiological treatment for acne vulgaris (author's transl)].		1974	4280517
immunotherapy of guinea pig cancer with bcg.		1974	4608693
antibiotic usage in dermatological practice.		1974	4609931
depression of delayed-type hypersensitivity by corynebacterium parvum: mandatory role of the spleen.		1974	4281350
studies on the mechanism of action to topical benzoyl peroxide and vitamin a acid in acne vulgaris.		1974	4283462
acne vulgaris and free fatty acids. a review and criticism.		1974	4275329
the glycerol ester hydrolase (ec 3.1.1.3) from corynebacterium acnes: a serine lipase.		1974	4275466
[study of anaerobic corynebacteria isolated from 9 000 hemocultures].		1974	4619759
non-specific immunostimulation in bronchogenic cancer.		1974	4370224
the effect of bacterial adjuvants on allograft survival after anti-lymphocyte serum (als) and donor bone marrow in mice.		1974	4373388
the mechanism of inhibition by corynebacterium parvum of the growth of lung nodules from intravenously injected tumour cells.		1974	4376512
properties of corynebacterium acnes bacteriophage and description of an interference phenomenon.	nine virulent bacteriophages of the anaerobe corynebacterium (propionibacterium) acnes, the p-a series, are dna phages, with long, curved nonretractile tails (130 nm) without tail plates or fibers. they have isometric heads (420 by 460 nm), and are placed in bradley's group b-1. there is permanent plaque suppression at highest phage concentrations. after 100- to 1,000-fold dilution, plaques are evident. the latent period is 1 h and burst size 25. cross-neutralization data of antisera for the nin ...	1974	4431080
antitumour effects of corynebacterium parvum in mice.		1974	4435007
studies on the organ uptake of 51cr-labeled sheep erythrocytes in the evaluation of stimulation of res phagocytic function in the mouse.		1974	4455902