Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| reproducible plaquing system for rabies virus in cer cells. | 1982 | 7107802 | |
| intradermal immunization with human diploid cell rabies vaccine. serological and clinical responses of persons with and without prior vaccination with duck embryo vaccine. | intradermal administration of human diploid cell rabies vaccine (hdcv) was investigated in an attempt to reduce the current high cost of preexposure rabies prophylaxis. the study population consisted of 240 volunteers from a veterinary hospital, 165 of whom had prior vaccination with duck embryo rabies vaccine (dev). vaccine safety was good; only minor reactions were experienced, all of which resolved spontaneously. serological responses to intradermal hdcv were excellent; 209 (99.5%) of the 210 ... | 1982 | 7109184 |
| animal rabies. papers presented at the joint scientific meeting on animal rabies. 3 to 5 june 1982, nancy, france. | 1982 | 7128057 | |
| scanning and freeze-fracture electron microscopy of rabies virus infection in murine neuroblastoma cells. | a persistent infection of cvs strain of rabies virus was established in murine neuroblastoma cells, c-1300, by a serial passage of the cells infected with a low input multiplicity. little cytopathic effects were seen in the infected cultures and the cell growth was not interfered, although 90-100% of the cells were bearing intracytoplasmic inclusions and the infectious virus was constantly recovered from the supernatant. scanning electron microscopy disclosed preferential budding of the virus fr ... | 1982 | 7128058 |
| avirulent mutants of the cvs strain of rabies virus. | two avirulent mutants of the cvs strain of rabies virus have been isolated on the basis of their loss of sensitivity to antiglycoprotein neutralizing monoclonal antibodies. with the exception of virulence, both retain general characteristics of the cvs strain of the rabies virus. after inoculation, they induce a strong and rapid immune response in adult mice. in this respect, however, they are quite different from the parental cvs strain. surviving mice are protected against intramuscular challe ... | 1982 | 7128059 |
| [role of interferon in rabies immunity]. | cell cultured rabies vaccines, usually induce a good production of interferon. a comparative study shows that vaccines from primary explantation cell cultures are better interferon inducers. taking into account the importance of this induction in rabies vaccination, a study showing the role of leucocyte interferon (alpha-type) is achieved. results show that leucocyte interferon (originating from the red cross, osaka, japan and institut pasteur production, paris) inhibits the formation of fluores ... | 1982 | 7128060 |
| [haemagglutination inhibition test: improvements, limits and advantages of the method. comparison with neutralization test]. | in this study, we report some technical improvements which enable us to envisage wider use of the haemagglutination test and haemagglutination inhibition of the rabies virus. moderated trypsination of sensitive red blood cells and their counting are important parameters. an interesting application of the test was the haemagglutination competition enabling the amount of soluble glycoprotein (obtained during the fractionating of the virus components) to be evaluated. from antibody kinetics of vacc ... | 1982 | 7128064 |
| small mammal studies in a sad baiting area. | studies in the laboratory or in the field on the effect of sad virus on small rodents are reported. laboratory experiments by oral inoculation of sad strain in a wide variety of small mammals led to the conclusion that spontaneous sad transmission from rodent to rodent is a rare event. field experiments were conducted by live-trapping, sacrifice and analysis of 192 apodemus sylvaticus, 28 clethrionomys glareolus and 48 crocidura russula. they gave no indication that sad virus became established ... | 1982 | 7128065 |
| safety tests with flury hep strain 675 in wild-living european mammals. | for the evaluation of residual pathogenicity of flury hep strain 675, the vaccinal virus was orally administered to 207 animals belonging to 15 wild-living and 1 domestic species. rabies virus antigen could be demonstrated by fa method in 20 animals. reisolation of the virus was possible from 23 animals within the first two weeks after application, the titres being very low. during the observation period of 100 days no symptoms of rabies could be observed in the animals tested. | 1982 | 7128066 |
| effectivity of oral vaccination of foxes against rabies with flury hep strain 675. | a group of 14 adult foxes was orally vaccinated with 2 ml flury hep strain 675, titre 10(8.2 tcid50. each fox seroconverted neutralizing antibody titres ranging between 1:40 and 1:640. these foxes survived an intramuscular challenge with 8000 mouse ld50 pathogenic rabies virus, whereas six out of seven unprotected control foxes died within 28 days. this study was accompanied by virus isolation, fluorescence microscopic examination and neutralization tests. | 1982 | 7128067 |
| [evaluation of an experimental rabies vaccine by the oral and intestinal route with inactivated vaccines, concentrated or non-concentrated]. | application of beta-propiolactone inactivated rabies vaccine prepared in bovine embryo kidney cells, concentrated or non concentrated, by intestinal or oral route resulted in antibody production in rats and cats. 80-100% of vaccinated rats were protected against challenge with street rabies virus. the same vaccines (lyophilized in gelatin capsules) stimulated antibody production in more than 50% (5/8) cats which received the vaccine by the oral route. | 1982 | 7128069 |
| [attenuated rabies virus, era strain, in cattle and dogs vaccinated with multiple doses]. | investigation on the vaccination of 18 cattle and 5 dogs against rabies is reported. each animal received multiple doses of era strain vaccine intramuscularly in the gluteal or masseter region. the saliva, the brain and salivary glands of the vaccinated animals were examined to detect the presence of era virus using immunofluorescent test and mouse inoculation. the virus was never found in the saliva and organs of treated animals. circulating antibodies against era rabies virus were detected in ... | 1982 | 7128070 |
| antibody levels following era rabies vaccine in cattle. | the humoral response in cattle treated with era strain rabies vaccine, was studied utilizing the following criteria: antibody titres determined by rffit, seroimmunological monitoring of experimentally vaccinated animals, a comparison of data obtained from cattle vaccinated and maintained under field conditions in the absence of anamnestic information. the average antibody responses in the field experiment are in agreement with the laboratory animal response, both showing highest levels at day 15 ... | 1982 | 7128071 |
| the structural proteins of rabies virus. | the five structural proteins of rabies virus, l, g, n, m1 and m2 have been re-evaluated in light of recent results. it has been found that the m1 protein is associated with the n protein which together with the l protein and the rna forms the nucleocapsid complex. only the g and m2 proteins could be visualized on the surface of infected cells. therefore, it is proposed that the m1 protein be renamed ns analogous to vesicular stomatitis virus and that the m2 protein, being the only membrane prote ... | 1982 | 7128073 |
| purification, concentration and evaluation of rabies virus antigen. | a number of concentration and purification procedures for rabies virus antigen have been developed during the last decades but only ultrafiltration and density gradient centrifugation have been found suitable for large scale production. the antibody binding test developed by arko, wiktor and sikes was modified and was found useful for evaluation of inactivated antigen-concentrates. this test was used as an 'in process' control. three examples of practical experience are reported and discussed. | 1982 | 7128074 |
| [modalities of production and immunity conferred by an inactivated rabies vaccine originating from cell culture]. | further to guidelines advised by the world health organization, an inactivated rabies vaccine was prepared from virus propagated on cell culture. this vaccine is presented either in the freeze-dried form or in the liquid form together with an immunity adjuvant. the specific and nonspecific immunity of the vaccine is excellent. the potency, tested in laboratory animals and in species for which the vaccine is intended, satisfies recommendations published by the w.h.o. the immunity persistence, eva ... | 1982 | 7128075 |
| potency of two rabies vaccines in cats as determined by antibody assay and virulent virus challenge. | the persistence of immunity induced by a modified live virus rabies vaccine (sad strain) and an inactivated rabies vaccine combined with panleukopenia vaccine in cats was studied serologically and by virulent rabies virus challenge. the source of challenge virus was a suspension of a dog salivary gland. all 16 cats vaccinated with the inactivated vaccine developed high antibody titres and 15 were protected against the virus challenge. all 8 cats vaccinated with the mlv vaccine produced a serolog ... | 1982 | 7128076 |
| [radio-tracking of rabid foxes]. | three wild foxes were trapped, inoculated with rabid fox salivary glands virus and radio-tracked straightaway for about three weeks until the death of the animal. comparison of movements between incubation and clinical period indicate principally no obvious alteration of the activity area; an important increase in movement, especially during the day-time and lastly some variable changes in the activity pattern according to the individual. a common characteristic was a long period of immobility, ... | 1982 | 7128084 |
| [influence of rabies virus culture duration on viral glycoprotein integrity]. | regardless of the duration of the culture period, the amount of both glycoprotein g and sialic acid bound to the rabies virion as not modified. the major proteins of the viral suspension were the same proteins as those of the virion, except one glycoprotein (mw 70,000). | 1982 | 7128091 |
| [possible role of ticks as a reservoir of rabies virus]. | in western europe the fox and other carnivora are parasitized by two specific ticks. the study of host-parasite relationships and knowledge of rabies epidemiology led us to investigate for a possible part played by ticks as reservoir of rabies virus. several hundreds of ticks (pholeoixodes hexagonus and pholeoixodes canisuga) were collected on wild foxes. ticks collected from naturally infected rabid foxes were set on healthy foxes in order to contaminate them. ticks collected from non-rabid fox ... | 1982 | 7128092 |
| [molecular and cellular aspects of the pathogenesis of rabies]. | the true causes of the beginning of the symptoms and the eventual mortality of rabies are not very well known. immunopathological factors certainly intervene, but they only complete a process of neuronal alteration. contrary to other viruses which lyse the infected cells, the rabies virus does not necessarily destroy the neurones which are the preferential target cells. on the contrary, rna synthesis is stimulated during cns infection by the rabies virus. synthesis is not stimulated by the multi ... | 1982 | 7128098 |
| [progression of the rabies virus in the visual system of the rat]. | the cvs rabies virus, inoculated in the anterior chamber of the eye, is transported from the retina to the central nervous system only along the accessory optic tract and invades transsynaptically its terminal nuclei. on the other hand the retino-geniculo-cortical system is affected much later. thus the virus shows a special affinity for a well defined neuronal system and behaves as a precise tracer of its intracerebral connections. | 1982 | 7128099 |
| rabies virus pathogenicity and challenge. influence of the method of preparation, the route of inoculation, and the species. comparison of the characteristics of the modified, fixed and wild strains. | the challenge we carried out, which regularly brought about the death of the control animals, led us to study the different factors influencing the pathogenicity of the rabies virus. so, the method of preparation is important. the strain nyc, prepared from the salivary glands is extremely pathogenic for dogs; however, when it is prepared from mouse brains after nine passages have been made, it proves to be already partially modified. one then notices a death-rate which is less severe, even when ... | 1982 | 7128100 |
| fatal encephalitis apparently due to rabies. occurrence after treatment with human diploid cell vaccine but not rabies immune globulin. | 1982 | 7131683 | |
| a sensitive bioassay system for detecting defective interfering particles of rabies virus. | 1982 | 7135836 | |
| [experimental transmission of rabies to the ferret by an ixodoidea: pholeoixodes rugicollis (schultze and schlottke, 1929)]. | 1982 | 7136476 | |
| haemadsorption test for rabies virus. | 1982 | 7142683 | |
| [humoral immune response as a laboratory criterion for evaluation of the effectiveness of rabies vaccines]. | 1982 | 7144329 | |
| [effect of cyclophosphane on the experimental production of abortive and chronic forms of rabies]. | 1982 | 7147907 | |
| a clinical study of merieux human rabies immune globulin. | 1982 | 7153223 | |
| geographic and seasonal distribution of rabies in skunks, foxes and bats in texas. | the geographic and seasonal distributions of the pathobiocenoses formed by rabies virus, the biotic provinces of texas, and skunks, foxes and bats were described using synoptic mapping and enumeration by calendar month. autocorrelation functions with 95% confidence intervals were calculated for the skunk pathobiocenose for lag periods up to 36 mo in length. the geographic distributions were fundamentally different, but all overlapped. the skunk and fox pathobiocenoses were associated with provin ... | 1982 | 7154216 |
| [biological variants of a population of strains of the rabies street virus]. | experiments in mice weighing 6-7 g showed that a population of wild street rabies virus strains could contain from 1 to 3 biologic variants determining the clinical characteristics, duration of the incubation period and of the disease, and virus titres in the brain. fox strains l-1 and l-2 produced only paralytic rabies, the be strain isolated from a badger induced paralytic and chronic disease, and the population of the yak strain isolated from a boy bitten by a fox and timely given a complete ... | 1982 | 7157781 |
| intradermal use of human diploid cell vaccine for preexposure rabies immunizations. | in a study involving 240 faculty, students, and staff at the university of georgia college of veterinary medicine, 0.1 ml of a rabies human diploid cell vaccine administered intradermally on days 0, 7, and 28 induced adequate rabies antibody (greater than or equal to 0.5 iu/ml of serum) in all subjects by day 49. there were no significant differences in mean titers between groups of individuals with different rabies immunization histories by using a newly proposed index system for reporting such ... | 1982 | 7161170 |
| immunization of foxes vulpes vulpes by the oral and intramuscular routes with inactivated rabies vaccines. | inactivated rabies vaccines prepared from common vaccine strains of virus were inoculated into foxes by the intramuscular and intestinal route. there were differences among the vaccines in the duration of antibody produced after intramuscular administration. inactivated vaccines deposited directly into the lumen of the duodenum by means of a fiberscope caused seroconversion in some foxes, especially following a booster dose, but the antibodies produced were for the most part of short duration. t ... | 1982 | 7172102 |
| [oral immunization of foxes against rabies: stabilization and use of bait for virus application]. | 1982 | 7180249 | |
| [antigenic variants of the rabies virus. selection with antiglycoprotein monoclonal antibodies]. | 1982 | 7181560 | |
| [preventive antirabies vaccination. evaluation of humoral immunity]. | 1982 | 7181561 | |
| [comparative study of 2 postexposure antirabies vaccines]. | 1982 | 7181562 | |
| [the reservoir of rabies virus in tunisia]. | 1982 | 7181568 | |
| [antigenic spectrum of wild strains and vaccinal strains of rabies virus in senegal defined by antinucleocapsid monoclonal antibodies]. | 1982 | 7181573 | |
| studies of the presence of rabies virus among stray dogs in dhaka city. | one hundred and thirty one stray dogs were captured from dhaka city. anti-mortem as well post-mortem examination of the dogs for rabies were conducted. microscopic studies and biological tests were carried-out with dog's brain for the detection of rabies virus. one dog was found to have rabies virus in its brain. the stray dogs under dhaka municipal corporation area therefore, seem to harbour rabies virus in their brains and could be a source of potential danger to the community after the full d ... | 1982 | 7184499 |
| [determination of the protective value of anti-rabies vaccines for human use in international units in the nih-test]. | 1982 | 7185030 | |
| non-bite transmission of rabies in kudu (tragelaphus strepsiceros). | the titres of rabies virus in the saliva of kudu are higher than those of the salivary glands. the high titres are an indication of active excretion and multiplication in tissues other than the salivary glands. two out of 4 kudu died of rabies after experimental infection by the instillation of infected saliva onto their buccal and nasal mucosae. mice and 2 cattle resisted a similar exposure. kudu also developed antibodies against rabies after instillation of hep flury virus onto their nasal and ... | 1982 | 7185035 |
| [development and persistence of the humoral immune response induced by the preventive treatment with rabies vaccine (hdcs) in a group of laboratory workers]. | 1982 | 7187849 | |
| [immune rabies status of 200 vaccinated dogs from the canton of zurich]. | 1982 | 7201161 | |
| enzyme-linked immunosorbent assay: a rapid reproducible test for the measurement of rabies antibody. | an enzyme-linked immunosorbent assay (elisa) was developed for detecting igg antibodies to the pitman moore strain of rabies virus in sera from subjects immunised wih hdcs vaccine. end-point titres of antibody were determined using a pocket calculator preprogrammed to analyse absorbence values of test sera and negative controls. the assay was highly reproducible, and very close agreement was achieved when the results were compared with those of the mouse neutralization test. rabies enzyme-linked ... | 1982 | 7038045 |
| rhesus diploid rabies vaccine (adsorbed), a new rabies vaccine. results of initial clinical studies of preexposure vaccination. | to meet the need for a safe, efficacious, and low-cost rabies vaccination program, the michigan department of public health developed a new rabies vaccine: rhesus diploid rabies vaccine, adsorbed (rdrv). initial clinical studies were conducted in 534 volunteers using preexposure protocols consisting of two injections of rdrv given 1, 2, or 4 weeks apart. this new rabies vaccine induced an excellent rabies virus antibody response two to three weeks after vaccination: antibody levels were superior ... | 1982 | 7038159 |
| pathogenesis of rabies in dogs inoculated with an ethiopian rabies virus strain. immunofluorescence, histologic and ultrastructural studies of the central nervous system. | dogs were inoculated with either an ethiopian of mexican rabies virus strain. the distribution of viral antigen and lesions were studied by immunofluorescence, histologic and electron microscopic techniques. in all dogs inoculated with the ethiopian rabies virus strain, tremendous whorls of filamentous fluorescing aggregates were observed throughout the brain; these were not observed in dogs inoculated with the mexican virus. lesions consisted on neuronal degeneration and neuronophagia, associat ... | 1982 | 7039557 |
| atypical rabies virus in cats and a dog in zimbabwe. | 1982 | 7043888 | |
| [chemotherapy of rabies virus in tissue culture]. | 1982 | 6186562 | |
| the use of monoclonal antibodies in virology. | 1982 | 6177742 | |
| [interferon and antirabies vaccination]. | 1982 | 6180483 | |
| frequency analysis of cytolytic t cell precursors (ctl-p) generated in vivo during lethal rabies infection of mice. i. distinction of ctl-p with different interleukin 2 sensitivity. | the aim of this study was to determine the number and state of activity of cytolytic t lymphocytes (ctl) and their precursors (ctl-p) present in vivo during the early stages of viral infection. the local response to lethal infection with rabies virus was used as a model system that is not accessible to analysis by secondary activation in vitro. the local response to alloantigen served as a control. experimental protocols were established that allow frequency estimates of in vivo antigen-triggere ... | 1982 | 6180904 |
| molecular basis of rabies virus virulence. i. selection of avirulent mutants of the cvs strain with anti-g monoclonal antibodies. | 1982 | 6181189 | |
| antigenic variants of rabies virus. | monoclonal antibodies directed either against the nucleocapsid or the glycoprotein of rabies virus were reacted by indirect immunofluorescence and mouse neutralization tests with vaccine strains and rabies field isolates of various origin. major antigenic determinants allow the grouping of viruses and minor ones the differentiation of virus strains. a protection study showed the existence in nature of certain antigenic variants against which conventional vaccines do not fully protect. the isolat ... | 1982 | 6181927 |
| [antigenic variants among street rabies virus isolates from france, africa, madagascar and asia. preliminary results with antinucleocapsid monoclonal antibodies]. | a panel of monoclonal antibodies directed against the nucleocapsid antigens of rabies virus allowed a rapid characterization of isolates by an indirect immunofluorescence test on brain smears of infected animals. analysis of 77 isolates (71 from animals and 6 from humans) showed a great diversity. isolates from different areas showed different patterns of reactivity. no relation was found between animal species and antigenic patterns specificity. | 1982 | 6181928 |
| antigenic variants of rabies virus. | the authors studied nineteen street virus isolates from different regions of canada using either anti-nucleocapsid and anti-glycoprotein monoclonal antibodies or cross-protection tests. this study only allowed us to recognize three groups of viruses with different nucleocapsid patterns, and no difference, as far as protection with a pitmann-moore vaccine is concerned, between four of these strains. | 1982 | 6181929 |
| [introduction to the study of antigenic variants of rabies virus]. | 1982 | 6181930 | |
| [antigenic variants of rabies virus in france. monoclonal antibodies]. | one hundred and sixteen rabies field isolates from france were studied with monoclonal antibodies for analysis of their nucleocapside antigenic characteristics (by direct or indirect immunofluorescence) or glycoprotein determinants (by neutralization in mice). these studies verified that nucleocapside antigens had only two variants, apparently uncorrelated to animal species or geographic areas. glycoprotein antigens had also variants which could explain partial defection in cross protection obse ... | 1982 | 6181931 |
| monoclonal antibodies study on rabies virus antigens in thailand. | 1982 | 6183386 | |
| antigenic structure of rabies virus glycoprotein: ordering and immunological characterization of the large cnbr cleavage fragments. | after rabies virus glycoprotein was treated with cnbr, the peptide mixture was fractionated by preparative sodium dodecyl sulfate-polyacrylamide gel electrophoresis. cnbr-cleaved peptide fragments were resolved into seven peptide bands under reducing conditions and six peptide bands under nonreducing conditions. the isolated nonreduced polypeptides were further analyzed by electrophoresis under reducing conditions. the n-terminal amino acid sequences were determined for the peptides in each of t ... | 1982 | 6183450 |
| commercial antirabies vaccine used as antigen in a modified enzyme-linked immunosorbent assay. | 1982 | 6124116 | |
| human rabies after late administration of human diploid cell vaccine without hyperimmune serum. | 1982 | 6126724 | |
| viraemia in rabies. | 1982 | 6127940 | |
| [rabies vaccine in czechoslovakia. i. hempt's vaccine and its modification]. | 1982 | 6215991 | |
| ph-dependent hemolysis and cell fusion of rhabdoviruses. | human erythrocytes pretreated with fungal semialkali protease or trypsin became susceptible to hemagglutination by vesicular stomatitis virus (vsv) and rabies virus. both viruses exhibited extensive hemolytic and fusion activities against erythrocytes pretreated with these enzymes. the hemolysis and fusion were ph dependent and the activities were most apparent at ph 5.0 and decreased with increase in ph. however, vsv still exhibited slight hemolytic activity at neutral ph. hemolysis was also de ... | 1982 | 6300613 |
| analysis of viral and defective-interfering nucleocapsids in acute and persistent infection by rhabdoviruses. | we have isolated and characterized the rna of intracellular virus nucleocapsids recovered from a number of cell cultures persistently infected with rabies virus or vesicular stomatitis virus (vsv). vsv persistent infections in bhk21, l cells and aedes albopictus (mosquito) cells generally showed the presence of large amounts of defective-interfering (di) nucleocapsid rna and much smaller amounts of standard (b) nucleocapsid rna. persistent infections of bhk21 cells by two rabies virus strains, c ... | 1982 | 6284869 |
| pseudorabies virus infection in raccoons: a review. | pseudorabies is a rarely reported disease of raccoons. laboratory and field evidence of prv infection suggests the raccoon is a "dead end" host with little opportunity for raccoon-to-raccoon spread of virus. all reported field cases have been associated closely with infected swine and swine have been considered the source of the raccoon infection. the clinical signs of prv in raccoons closely resembles those of canine distemper and rabies virus infections. infection with the latter viruses are c ... | 1982 | 6285008 |
| homology between the glycoproteins of vesicular stomatitis virus and rabies virus. | we compared the predicted amino acid sequences of the vesicular stomatitis virus and rabies virus glycoproteins by using a computer program which provides an optimal alignment and a statistical significance for the match. highly significant homology between these two proteins was detected, including identical positioning of one glycosylation site. a significant homology between the predicted amino acid sequences of vesicular stomatitis virus and influenza virus matrix proteins was also found. | 1982 | 6287013 |
| cellular response to rabies virus infection. | the effects of rabies virus on host cells were studied and compared to those obtained with another rhabdovirus, vesicular stomatitis virus [j. virol. 34, 777-781 (1980)]. we show here: (1) that rabies infection has no effect on cell morphology, while infection with vesicular stomatitis virus caused cell retraction. thus, only vesicular stomatitis virus induced a depolymerization of the microfilaments; and (2) that microtubules and microfilaments do not play a major role in rabies virus productio ... | 1982 | 6290135 |
| [protective action of undegraded and s-sulfonated 7s antibodies in 4 different experimental virus infections]. | 1982 | 6293456 | |
| [aspects of molecular biology of the rabies virus]. | 1982 | 6295294 | |
| time dependent decreases of maternal canine virus antibodies in newborn pups. | levels of passively transferred maternal antibodies to three canine viruses, rabies virus (rv), canine distemper virus (cdv) and infectious canine hepatitis (ich) virus, in serum specimens from 14 fetal pups and in serial serum specimens collected up to 45 days after whelping from 14 neonate pups were compared with levels of antibodies to these viruses in milk and sera collected concurrently from their respective dams. radioimmunoassays using rv-, cdv- and ich virus-specific antigens showed that ... | 1981 | 6262993 |
| interference induced in gl-v3 monkey kidney cells by rabies virus strains. | resistance to superinfection with vesicular stomatitis virus (vsv) occurred in gl-v3 monkey kidney cells infected with the cvs-11, pitman moore, lep flury, but not the era strain of rabies virus. specific immunofluorescent staining of intracellular rabies antigen showed that the number and size of fluorescent foci increased after the onset of interference, and that this was paralleled by increasing yields of infectious virus. although cvs-11 and era differed in their ability to induce interferen ... | 1981 | 6267182 |
| structure of the glycoprotein gene in rabies virus. | 1981 | 6272128 | |
| rabies virus decreases agonist binding to opiate receptors of mouse neuroblastoma-rat glioma hybrid cells 108-cc-15. | 1981 | 6272776 | |
| mouse model for abortive rabies infection of the central nervous system. | when adult mice were injected by the footpad route with the attenuated rabies virus era/bhk, serum- and brain-associated antibody and interferon were produced, nonspecific cytotoxic cells and virus-specific cytolytic t cells in the spleen were activated, and a nonlethal infection of the central nervous system occurred. cyclophosphamide treatment of these animals 1 day after virus infection suppressed antibody formation and induction of cytolytic t cells and resulted in a lethal infection. virus ... | 1981 | 6163717 |
| essential role of t cells in the postexposure prophylaxis of rabies in mice. | athymic nude mice injected intramuscularly with a street stain of rabies virus were not protected against rabies by postexposure administration of beta-propiolactone-inactivated rabies vaccine. in contrast, their normal littermates were completely protected from death by the same vaccination regimens. nude mice did not produce igg antibody as a result of the vaccine during the test period of 15 days, whereas normal littermates produced igg antibody from day 5 after vaccination. however, passive ... | 1981 | 6171709 |
| immunofluorescent staining of rabies virus antigen in formalin-fixed tissue after treatment with trypsin. | formalin-fixed central nervous system tissue from clinically rabid animals was treated with 0.25% trypsin and tested for the presence of rabies virus antigen by direct immunofluorescent (if) staining. the results were comparable with those obtained from direct if staining of acetone-fixed standard smears or fresh frozen-cut sections. experiments were conducted using coded brain specimens (classified as if-negative, weakly positive, or strongly positive) and showed a specificity of 100% for secti ... | 1981 | 6172212 |
| [prevention of inter-human rabies transmission after corneal graft]. | transplantation, to a normal recipient, of a cornea taken from a donor who died of rabies encephalitis constitutes an extremely serious exposure. four cases, up to now are known of human to human transmission of rabies virus. in these four cases, the diagnosis of rabies in the donor has been made afterwards when to the recipient developed fatal rabies. we report here the first case of this type of exposure where the diagnosis of rabies in the donor could be made on the day following the transpla ... | 1981 | 6175385 |
| lagos bat virus in south africa. | 1981 | 6111687 | |
| rabies: a little antibody a dangerous thing? | 1981 | 6112418 | |
| rabies virus and laboratory regulations. | 1981 | 6113412 | |
| rabies virus and laboratory regulations. | 1981 | 6114274 | |
| rabies virus and laboratory regulations. | 1981 | 6114354 | |
| freeing rabies virus of the neuroallergenic factor from brain tissue. | a method of fixed rabies virus purification from infected sheep brains was proposed. it consisted of suspending the brain tissue in phosphate-buffered hypertonic (0.3 m) nacl solution, shaking at 37 degrees c and low speed centrifugation at the same temperature. from 65 to 85% ballast proteins were removed, the neuroallergenic activity of the material was lost, but practically no losses of the virus occurred. | 1981 | 6115564 |
| separation of two street rabies virus strain populations into two biological variants. | 1981 | 6115568 | |
| purification and concentration of rabies virus by chromatography on chemically modified porous silicates. | tissue culture rabies virus was purified by gel chromatography on chemically modified macroporous glasses (mpg). modification of the mpg surface by egg or human albumin prevented rabies virions from interaction with the glass surface so that all purified virus was eluted from the column. chemically modified mpg could be used on a preparative scale for the purification of both infectious and inactivated rabies virus, the immunogenicity of the latter having been preserved. protein content of the p ... | 1981 | 6116414 |
| multisite intradermal antirabies vaccination. immune responses in man and protection of rabbits against death from street virus by postexposure administration of human diploid-cell-strain rabies vaccine. | lymphocyte transformation, production of neutralising antibody, and the development of antirabies igg antibody were studied in ten healthy volunteers in response to 0.8 ml of human diploid-cell strain (hdcs) rabies vaccine administered on one occasion in divided doses in 8 intradermal (i.d.) sites. all ten volunteers rapidly developed substantial titres of rabies antibody, and eight of the ten had t lymphocytes that were immunologically stimulated by hdcs rabies-virus antigen. postexposure treat ... | 1981 | 6117693 |
| properties of rabies vaccine freed of neuroallergenic factor from brain tissue. | fixed rabies virus in the form of infected sheep brain suspension was freed from approx. 80% of ballast proteins, inactivated by beta-propiolactone and lyophilized. the vaccine thus obtained was devoid of neuroallergenicity when tested on guinea pigs and was highly antigenic and immunogenic. the vaccine caused no generalized reactions in volunteers; local reactions were weak and of short duration. antibody formation was intensive in all volunteers. | 1981 | 6118049 |
| cellular tests for assessing the immunogenicity of rabies vaccines. | 1981 | 7053012 | |
| [comparison of inactivated rabies vaccines obtained from diploid and polyploid heterologous cells (hak, bhk, and vero)]. | homologous or heterologous diploid or polyploid cells have been established as good producers of virus. in this study we present three types of experimental inactivated antirabies vaccines obtained under identical conditions from three types of cells. the study concerns the following characteristics of the vaccines: protecting powers, rabies antigens and major polypeptidic components; this study was performed on supernatants of tissue cultures and concentrated and purified vaccines. moreover, so ... | 1981 | 7316614 |
| rabies virus tropism in naturally infected skunks (mephitis mephitis). | 1981 | 7041707 | |
| rabies in a litter of skunks predicted and diagnosed by skin biopsy. | four juvenile skunks were vaccinated against rabies, descented, and then placed in 4 different households. an illness subsequently developed in 3 of the skunks that was confirmed as rabies, by examination of biopsy specimens of muzzle skin using immunofluorescence microscopy. in 1 clinically normal skunk, the skin was found to be test-positive, predicting that rabies would develop; the signs of rabies became evident in 48 hours. the infection was considered to be field acquired rather than vacci ... | 1981 | 7042667 |
| rapid antibody response to human diploid rabies vaccine. | the speed of antibody response to two administration schedules of human diploid cell strains rabies vaccine (hdcv) was measured in two groups of veterinary students as a preliminary study to the use of interferon inducers plus vaccine for rabies treatment. when four doses of hdcv were administered in three days instead of four doses in 14 days, 94.7 per cent of those injected had antibody by the seventh day, versus 31.6 per cent in the 14-day group. the maximum titer was lower and antibody fell ... | 1981 | 7468581 |
| single-site localization of rabies virus: impact on laboratory reporting policy. | information accumulated by our rabies laboratory during 1977-1979 was retrospectively analyzed for patterns of rabies localization in brain. of the 1,730 specimens reported positive during that period, 37 were positive at a single site, 27 involving only the cerebellum. therefore, we recommend that those laboratories which offer the fluorescent rabies antibody test (fra) examine both cerebellum and hippocampus. definitive reports based on the fra should be offered only when both sites have been ... | 1981 | 7468888 |
| [activity control of inactivated rabies vaccines. critical study of the n.i.h. test using the so-called 'peripheric test' as an experimental model]. | 1981 | 7217107 | |
| comparative study of rabies virus persistence in human and hamster cell lines. | persistent infections by rabies virus in bhk-21/13s and hep-2 cells were studied comparatively. no evidence of interferon production, selection of virus-resistant cells, or integration of the viral genome could be found. persisting viruses replicated efficiently at 34, 36, and 40 degrees c. both persistently infected cultures released defective interfering virus particles. a cyclical pattern of infection, which was not characteristic of the persistently infected hep-2 system, was observed in per ... | 1981 | 7218421 |
| antibody-mediated enhancement of rabies virus. | 1981 | 7219541 | |
| [pathomorphology of abortive rabies]. | white random-bred mice inoculated intraperitoneally with street rabies virus were found to have numerous babes-negri bodies in cerebral neurons very frequently up to 5 days of the disease. on the 7-11th days of the disease the inclusions were found in some neurons in 11 of 17 mice examined. among 24 mice with abortive rabies (recovering completely or surviving with residual symptoms such as pareses or paralysis) examined on the 20-240th days after the onset occasional babes-negri bodies were fou ... | 1981 | 7257316 |