Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| lymphomatoid granulomatosis involving the central nervous system: a case report and review of the literature. | lymphomatoid granulomatosis (lyg) is a rare tumor with unknown etiology. specific etiological factors for lyg are also unknown, although previous data indicates that lyg is an epstein-barr virus-associated b-cell proliferation associated with an exuberant t-cell reaction. according to the 2008 who classification, lyg is characterized by b-cell proliferation of b-lymphoma cells. generally, treatment options for lyg are similar to those for diffuse large b-cell lymphoma. unfortunately, lyg is a ch ... | 2014 | 24932245 |
| burkitt lymphoma: epidemiological features and survival in a south african centre. | the epidemiology of burkitt lymphoma (bl) shows that the endemic type is mainly confined to equatorial africa and has a very close association with the epstein-barr virus (ebv), while the sporadic variant shows only a 20% association with ebv and is seen mainly in europe and north america. an immunodeficent form of bl has been described more recently. this study aimed to describe the epidemiological characteristics and survival of children presenting with bl to tygerberg hospital, cape town, in ... | 2014 | 24932211 |
| pityriasis rubra pilaris (prp) with preceding epstein-barr virus infection: a new type prp with non-hiv virus infection? | 2014 | 24931263 | |
| improved elongation factor-1 alpha-based vectors for stable high-level expression of heterologous proteins in chinese hamster ovary cells. | establishing highly productive clonal cell lines with constant productivity over 2-3 months of continuous culture remains a tedious task requiring the screening of tens of thousands of clonal colonies. in addition, long-term cultivation of many candidate lines derived in the absence of drug selection pressure is necessary. expression vectors based on the elongation factor-1 alpha (eef1a) gene and the dihydrofolate reductase (dhfr) selection marker (with separate promoters) can be used to obtain ... | 2014 | 24929670 |
| ebi3 is pivotal for the initiation of experimental autoimmune uveitis. | murine experimental autoimmune uveitis (eau) is a model for human autoimmune uveitis, whose pathogenesis is caused by both th1 and th17 cell responses. epstein-barr virus-induced gene 3 (ebi3) is a component of the heterodimeric cytokines: interleukin (il)-27 and il-35. although il-27 was shown to initiate th1 cell development, it is also recognized as a negative regulator of fully activated cd4+ t cells, including th17 cells. recently, il-35 also has also been reported to play immunosuppressive ... | 2014 | 24929202 |
| hematopoietic cell transplantation for plasmablastic lymphoma: a review. | plasmablastic lymphoma (pbl) is recognized by the world health organization as a very aggressive subtype of non-hodgkin lymphoma. it was initially described in the setting of human immunodeficiency virus (hiv) infection, but it has since been identified in immunocompetent patients, as well. pbl is characterized by cd20 negativity and is associated with epstein-barr virus infection. the outcome with available therapy is poor, with median survival of less than 1 year. multiple adverse prognostic f ... | 2014 | 24946718 |
| race/ethnic and socioeconomic differences in stress and immune function in the national longitudinal study of adolescent health. | stress and immune function may be important mediators of the strong association between social factors and health over the life course, but previous studies have lacked the data to fully explore these links in a population-based sample. this study utilizes data from waves i-iv of the u.s. national longitudinal study of adolescent health (add health) to test the associations of race/ethnicity and socioeconomic status (ses) with levels of perceived stress and exposure to stressful life events (sle ... | 2014 | 24946263 |
| attachment anxiety is related to epstein-barr virus latency. | attachment theory provides a framework for understanding individual differences in chronic interpersonal stress. attachment anxiety, a type of relationship insecurity characterized by worry about rejection and abandonment, is a chronic interpersonal stressor. stress impacts cellular immunity, including herpesvirus reactivation. we investigated whether attachment anxiety was related to the expression of a latent herpesvirus, epstein-barr virus (ebv), when individuals were being tested for breast ... | 2014 | 24945717 |
| the first endogenous herpesvirus, identified in the tarsier genome, and novel sequences from primate rhadinoviruses and lymphocryptoviruses. | herpesviridae is a diverse family of large and complex pathogens whose genomes are extremely difficult to sequence. this is particularly true for clinical samples, and if the virus, host, or both genomes are being sequenced for the first time. although herpesviruses are known to occasionally integrate in host genomes, and can also be inherited in a mendelian fashion, they are notably absent from the genomic fossil record comprised of endogenous viral elements (eves). here, we combine paleovirolo ... | 2014 | 24945689 |
| tumor microenvironment and rig-i signaling molecules in epstein barr virus-positive and -negative classical hodgkin lymphoma of the elderly. | classical hodgkin lymphoma (chl) is a b-cell neoplasm characterized by hodgkin and reed-sternberg (hrs) cells. its prevalence exhibits a bimodal pattern of peaking in young adults and the elderly. there is an association with epstein-barr virus (ebv) infection in about 50% of cases of chl of the elderly, and the outcome of these patients is unfavorable. it is not well known how the latent infection of ebv is involved in the pathophysiology of chl of the elderly. to address this issue, we examine ... | 2014 | 24942949 |
| a de novo monoclonal immunoglobulin deposition disease in a kidney transplant recipient: a case report. | myeloma following kidney transplantation is a rare entity. it can be divided into two groups: relapse of a previous myeloma and de novo myeloma. some of these myelomas can be complicated by a monoclonal immunoglobulin deposition disease, which is even less common. less than ten cases of monoclonal immunoglobulin deposition disease after renal graft have been reported in the literature. the treatment of these patients is not well codified. | 2014 | 24942882 |
| latent membrane protein 1 and the b lymphocyte-a complex relationship. | the epstein barr virus (ebv)-encoded latent membrane protein 1 (lmp1) exerts numerous impacts on the functions of b lymphocytes, the cell type in which ebv establishes long-term latent infections. lmp1 expression has been implicated in making important contributions to a variety of human malignancies, as well as to autoimmune diseases. ebv also infects other types of immune cells, as well as nasopharyngeal epithelium, and evidence suggests that lmp1 functions may differ among cell types. in this ... | 2014 | 24941072 |
| clinical analysis of 102 cases of epstein-barr virus infections in chinese children. | the purpose of this study is to investigate the clinical manifestations and disease severity, to evaluate the recent trend of clinical manifestations and differences in the clinical and laboratory findings of ebv-associated im (infectious mononucleosis) according to the age of children. we retrospectively collected cases on hospitalized patients a majority of 7 years old with characteristic symptoms of im and serologically diagnosed ebv-associated im at shaanxi provincial peoples university hosp ... | 2014 | 24940855 |
| hits-clip and par-clip advance viral mirna targetome analysis. | mirnas regulate gene expression by binding predominantly to the 3' untranslated region (utr) of target transcripts to prevent their translation and/or induce target degradation. in addition to the more than 1200 human mirnas, human dna tumor viruses such as kaposi's sarcoma-associated herpesvirus (kshv) and epstein-barr virus (ebv) encode mirnas. target predictions indicate that each mirna targets hundreds of transcripts, many of which are regulated by multiple mirnas. thus, target identificatio ... | 2014 | 24940765 |
| the expression of renal epstein-barr virus markers in patients with lupus nephritis. | the aim of this study was to investigate the role of renal epstein-barr virus (ebv) infection in the pathogenesis of lupus nephritis (ln). a total of 58 renal tissue samples from patients with ln, seven normal renal tissue samples from patients with non-glomerular hematuria and 37 renal tissue samples from patients with minimal change nephropathy were collected. the expression of ebv-latent membrane protein-1 (ebv-lmp1) and ebv-encoded rna 1 (eber-1) in the renal tissue was examined by immunohis ... | 2014 | 24940399 |
| continuity and innovation in the data collection protocols of the second wave of the national social life, health, and aging project. | the second wave (w2) of the national social life, health, and aging project (nshap), a nationally representative, longitudinal survey of older adults now between the ages of 62 and 90, conducted approximately 3,400 interviews. selected coresidential romantic partners as well as w1 panel nonrespondents were selected for w2. data collection included in-person questionnaires, up to 15 biomeasures, and a post-interview questionnaire. | 2014 | 24939998 |
| chronic active epstein-barr virus infection complicated with multiple artery aneurysms. | 2014 | 24939943 | |
| hiv-related nk/t-cell lymphoma in the brain relapsed during intensive chemotherapy but regressed after chemotherapy discontinuation: the importance of maintaining cellular immunity. | this study reports a case of human immunodeficiency virus (hiv)-related natural killer/t-cell lymphoma with an unexpected clinical course. the lymphoma cells were positive for epstein-barr virus and the primary nodal lesions regressed after chemotherapy and combined antiretroviral therapy (c-art); however, brain metastasis progressed along with a reduction in the cd8+ t-cell count. chemotherapy was discontinued and the patient was treated with c-art alone, resulting in regression of the brain le ... | 2014 | 24938379 |
| prevalence and prognostic significance of epstein-barr virus infection in classical hodgkin's lymphoma: a meta-analysis. | the prevalence and prognostic significance of epstein-barr virus (ebv) infection in classical hodgkin's lymphomas (chls) remain elusive. to examine the epidemiological and prognostic differences between ebv-positive and -negative chls, we conducted a meta-analysis of 119 published studies including 13,045 cases. | 2014 | 24937173 |
| aberrant satb1 expression is associated with epstein-barr virus infection, metastasis and survival in human nasopharyngeal cells and endemic nasopharyngeal carcinoma. | special at-rich sequence-binding protein 1 (satb1) has been identified as a key factor in the progression of some cancers, functioning as a global genome organizer and chromatin regulator. we examined the levels of satb1 mrna expression in npc cell lines 5-8f (high metastasis) and 6-10b (low metastasis) and immortalized human nasopharyngeal epithelial cells np69-sv40t by quantitative real-time pcr. we also examined the protein expression levels of satb1 in 72 cases of nasopharyngeal carcinoma (n ... | 2014 | 24966956 |
| spectrum of epstein-barr virus-associated t-cell lymphoproliferative disorder in adolescents and young adults in taiwan. | epstein-barr virus (ebv) is a herpesvirus usually infecting b-cells but may occasionally infect t- or natural killer (nk)-cells. ebv-associated t- or nk-cell lymphoproliferations represent a continuous spectrum of diseases ranging from asymptomatic infection, infectious mononucleosis (im), to clonal and malignant lymphoproliferations including systemic ebv-positive t/nk-cell lymphoproliferative disease (ebv-t/nk-lpd) of childhood and hydroa-vacciniforme-like lymphoma of the skin. the clonal dise ... | 2014 | 24966953 |
| clinicopathologic characteristics of inflammatory pseudotumor-like follicular dendritic cell sarcoma. | inflammatory pseudotumor (ipt)-like follicular dendritic cell (fdc) sarcoma is a recently described rare tumor and considered a unique entity, with different histologic appearances and behavior from those of the classical fdc sarcoma. this study analyzed the clinical and pathological findings of two such cases that the authors encountered and 36 previously reported cases identified in the literature. assessment of all 38 cases showed a slight female predominance (2.2:1) with a median age of 56.5 ... | 2014 | 24966952 |
| dual expression of epstein-barr virus, latent membrane protein-1 and human papillomavirus-16 e6 transform primary mouse embryonic fibroblasts through nf-κb signaling. | the prevalence of epstein-barr virus (ebv) and high-risk human papilloma virus (hpv) infections in patients with oral cancer in okinawa, southwest islands of japan, has led to the hypothesis that carcinogenesis is related to ebv and hpv co-infection. to explore the mechanisms of transformation induced by ebv and hpv co-infection, we analyzed the transformation of primary mouse embryonic fibroblasts (mefs) expressing ebv and hpv-16 genes, alone or in combination. expression of ebv latent membrane ... | 2014 | 24966902 |
| epstein-barr virus induced hemophagocytic lymphohistiocytosis in x-linked lymphoproliferative disease. | x-linked lymphoproliferative disease (xlp) is a rare, often fatal genetic disorder characterized by extreme vulnerability to epstein-barr virus (ebv). ebv-induced hemophagocytic lymphohistiocytosis (hlh) is a known presentation in xlp. in ebv-induced hlh in xlp, the brain imaging findings in the acute phase include a non specific pattern. in this report, we highlight the magnetic resonance imaging and magnetic resonance spectroscopy findings in a child with ebv induced hlh in xlp. | 2014 | 24966560 |
| histopathological features and their prognostic impact in nodular lymphocyte-predominant hodgkin lymphoma--a matched pair analysis from the german hodgkin study group (ghsg). | nodular lymphocyte-predominant hodgkin lymphoma (nlphl) is a rare lymphoma entity. we performed a matched-pair analysis to evaluate the prognostic impact of several histopathological features in this distinct hodgkin lymphoma subtype. lymph node samples of nlphl patients were tested for cd15, igd, phosphorylated stat6, icos and epstein-barr virus status of the malignant lymphocyte-predominant cells as well as epithelioid cell clusters and activated t cells in the microenvironment. none of these ... | 2014 | 24965443 |
| proposal of a clinical typing system and generation of a prognostic model in patients with nasopharyngeal carcinoma from southern china. | to propose a novel clinical typing classification focusing on the distinct progression patterns of nasopharyngeal carcinoma (npc), to supplement our knowledge of the clinical-biological behavior, to provide useful knowledge for treatment planning, and to contribute to basic research in npc. | 2014 | 24965409 |
| fatal pulmonary complications in an immunodeficient child with chronic active epstein-barr virus infection. | primary epstein-barr virus infection in children typically presents as infectious mononucleosis and in immunocompetent individuals severe pneumonitis proves to be a rare complication. chronic active epstein-barr virus infection (caebv) is associated with multiple life-threatening conditions, including interstitial lung disease with fibrosis and lymphoid and lymphohistiocytic infiltrations. we report on a pediatric patient in whom caebv resulted in severe pneumopathy with a fatal outcome. | 2014 | 24964240 |
| comparison of different rabbit atg preparation effects on early lymphocyte subset recovery after allogeneic hsct and its association with ebv-mediated ptld. | rabbit antithymocyte globulin (atg) is commonly used before allogeneic hematopoietic stem cell transplantation (allo-hsct) to prevent graft-versus-host disease. studies comparing the effect of different atg preparations and dosages on immune reconstitution and risk for epstein-barr virus (ebv)-mediated post-transplant lymphoproliferative disorder (ptld) are rare. | 2014 | 24962343 |
| pathobiology of hodgkin lymphoma. | hodgkin's lymphoma is a lymphoid tumour that represents about 1% of all de novo neoplasms occurring every year worldwide. its diagnosis is based on the identification of characteristic neoplastic cells within an inflammatory milieu. molecular studies have shown that most, if not all cases, belong to the same clonal population, which is derived from peripheral b-cells. the relevance of epstein-barr virus infection at least in a proportion of patients was also demonstrated. the real/who classifica ... | 2014 | 24959337 |
| [differential diagnosis of rheumatic diseases and blood cancers involving the nasal cavity and accessory sinuses]. | to provide the clinical, laboratory, radiological, morphological, and immunomorphological signs that permit the differential diagnosis to be made in patients with involvement of the nasal cavity and accessory sinuses (ncas). | 2014 | 25026804 |
| cytotoxic t-cell and nk-cell lymphomas: current questions and controversies. | the cytotoxic t-cell and natural killer (nk)-cell lymphomas and related disorders are important but relatively rare lymphoid neoplasms that frequently are a challenge for practicing pathologists. this selective review, based on a meeting of the international lymphoma study group, briefly reviews t-cell and nk-cell development and addresses questions related to the importance of precise cell lineage (αβ-type t cell, γδ t cell, or nk cell), the implications of epstein-barr virus infection, the sig ... | 2014 | 25025449 |
| combined linkage and association studies show that hla class ii variants control levels of antibodies against epstein-barr virus antigens. | over 95% of the adult population worldwide is infected with epstein-barr virus (ebv). ebv infection is associated with the development of several cancers, including hodgkin lymphoma (hl). elevated levels of anti-ebv antibodies have been associated with increased risk of hl. there is growing evidence that genetic factors control the levels of antibodies against ebv antigens. here, we conducted linkage and association studies to search for genetic factors influencing either anti-viral capsid antig ... | 2014 | 25025336 |
| lymphomatoid granulomatosis associated with azathioprine therapy in crohn disease. | lymphomatoid granulomatosis (lyg) is a rare epstein-barr virus-associated lymphoproliferative disorder. it most often occurs in patients with immunodeficiency and the clinical course ranges from indolent behavior to that of an aggressive malignancy. pulmonary, central nervous system and dermatological manifestations are most common. to our knowledge this is the first reported case of lyg related to azathioprine therapy in crohn disease. | 2014 | 25022612 |
| update on infections and vaccinations in systemic lupus erythematosus and sjögren's syndrome. | to provide an update on infections in systemic lupus erythematosus (sle) and sjögren's syndrome, particularly addressing their role as triggers of autoimmunity, their impact on mortality, the main microorganisms, the approaches to differential diagnosis with disease flares and recommendations for vaccination. | 2014 | 25022358 |
| synchronous tuberculosis, epstein-barr virus-associated lymphoproliferative disorder and cytomegalovirus infection in an allogeneic transplant recipient: a case report. | allogeneic stem cell transplant recipients are prone to infections by various organisms. tuberculosis (tb) represents a rare infectious complication, especially in countries non-endemic for tb. | 2014 | 25019038 |
| cutaneous intravascular natural killer-cell lymphoma: a case report and review of the literature. | to our knowledge, since 2003, there have been 11 reported cases of intravascular natural killer (nk)-cell lymphoma (ivnkl). herein we describe the 12th case. | 2014 | 25015867 |
| epstein-barr virus infections of the nervous system. | 2014 | 25015491 | |
| establishment and characterization of a rare atypical chronic myeloid leukemia cell line nt-1. | human leukemia cell lines are of great value in leukemia research. in this study, we established and described the biological characteristics of a rare atypical chronic myeloid (acml) leukemia cell line (nt-1). mononuclear cells were isolated from the bone marrow of a patient with atypical chronic myeloid leukemia (ph(-)/bcr(-)/abl(-)), and were passaged by liquid culture. cells were maintained without any cytokines for over 1 year, and named nt-1. this cell line was extensively characterized us ... | 2014 | 25012564 |
| low-dose otelixizumab anti-cd3 monoclonal antibody defend-1 study: results of the randomized phase iii study in recent-onset human type 1 diabetes. | previous studies demonstrated that the anti-cd3 monoclonal antibody otelixizumab, administered at a total dose of 48-64 mg, can slow the loss of c-peptide in recent-onset type 1 diabetes patients, with frequent reactivation of epstein barr virus (ebv). the defend-1 (durable response therapy evaluation for early or new-onset type 1 diabetes) trial was designed to test whether a lower dose of otelixizumab could preserve c-peptide secretion in new-onset type 1 diabetes patients. | 2014 | 25011949 |
| modelling the structure of full-length epstein-barr virus nuclear antigen 1. | epstein-barr virus is a clinically important human virus associated with several cancers and is the etiologic agent of infectious mononucleosis. the viral nuclear antigen-1 (ebna1) is central to the replication and propagation of the viral genome and likely contributes to tumourigenesis. we have compared ebna1 homologues from other primate lymphocryptoviruses and found that the central glycine/alanine repeat (gar) domain as well as predicted cellular protein (usp7 and ck2) binding sites are pres ... | 2014 | 25011696 |
| long-term complete remission of multiple extranodal natural killer/t-cell-type posttransplant lymphoproliferative disorder after surgical resection: a case report. | posttransplant lymphoproliferative disorder (ptld) is a life-threatening complication of organ transplantation that results from immunosuppression therapy. most cases of ptld derive from the b-cell lineage. t-cell ptld, particularly natural killer (nk)/t-cell ptld, is quite rare; only a few cases have been described. | 2014 | 25011572 |
| association of epstein-barr virus and passive smoking with the risk of breast cancer among chinese women. | reactivation of epstein-barr virus (ebv), as indexed by the higher immunoglobulin a (iga) antibody titers, was reported to be associated with an increased risk of breast cancer. passive smoking plays a role in host immune responses and may modify the association of ebv with breast cancer. we carried out a case-control study using data from 349 incident breast cancer cases and 500 age-matched controls in the guangzhou breast cancer study to investigate the interactions of ebv antibodies and passi ... | 2014 | 25010836 |
| epstein-barr virus-positive polymorphous lymphoplasmacytic infiltrate of the lacrimal glands in a patient with acute lymphoblastic leukemia. | 2014 | 25010171 | |
| vitamin d levels and monospot tests in military personnel with acute pharyngitis: a retrospective chart review. | some recent studies have proposed an important role for vitamin d in reducing the risk of infection by assisting in the suppression of viruses and by controlling the inflammatory response. a low vitamin d state may have a detrimental effect on the immune system's ability to produce activated cd8+ t cells, and it may increase the inflammatory reaction to epstein barr virus. the aim of this chart review was to see if serum 25 oh vitamin d3 levels in service members with acute pharyngitis were lowe ... | 2014 | 25009977 |
| ebv-positive mucocutaneous ulcer in organ transplant recipients: a localized indolent posttransplant lymphoproliferative disorder. | epstein-barr virus (ebv)-positive mucocutaneous ulcer (ebv mcu) is a b-cell lymphoproliferative disorder occurring in elderly or iatrogenic immunocompromised patients. it has not been reported in solid organ transplant recipients. we observed 7 patients with ebv mcu in a cohort of 70 transplant recipients with ebv posttransplant lymphoproliferative disorder (ptld). transplants included: 5 renal, 1 heart, and 1 lung. median patient age was 61; 5 were male. ebv mcu was observed in oral mucosa in 4 ... | 2014 | 25007145 |
| dendritic cells during epstein barr virus infection. | epstein barr virus (ebv) causes persistent infection in more than 90% of the human adult population and is associated with 2% of all tumors in humans. this γ-herpes virus infects primarily human b and epithelial cells, but it has been reported to be sensed by dendritic cells (dcs) during primary infection. these activated dcs are thought to contribute to innate restriction of ebv infection and initiate ebv-specific adaptive immune responses via cross-priming. the respective evidence and their po ... | 2014 | 24999343 |
| decreased il-35 levels in patients with immune thrombocytopenia. | il-35 is a novel heterodimeric anti-inflammatory cytokine consisting of epstein-barr virus-induced gene 3 (ebi3) and the p35 subunit of il-12. il-35 has been shown to possess the potency of inhibiting the cd4+ effector t cells and alleviating autoimmune diseases. in the study we investigated the levels of il-35 as well as its prospective role in immune thrombocytopenia (itp).elisa was adopted to measure plasma il-35, tgf-β and il-10 levels. the mrna expression levels of p35 and ebi3 in periphera ... | 2014 | 24994465 |
| epstein-barr virus (hhv-4) inoculation to rabbits by intranasal and oral routes results in subacute and/or persistent infection dissimilar to human disease. | we report the infection of new zealand white rabbits with epstein-barr virus (ebv). | 2014 | 24993954 |
| genomic diversity of epstein-barr virus genomes isolated from primary nasopharyngeal carcinoma biopsy samples. | undifferentiated nasopharyngeal carcinoma (npc) has a 100% association with epstein-barr virus (ebv). however, only three ebv genomes isolated from npc patients have been sequenced to date, and the role of ebv genomic variations in the pathogenesis of npc is unclear. we sought to obtain the sequences of ebv genomes in multiple npc biopsy specimens in the same geographic location in order to reveal their sequence diversity. three published ebv (b95-8, c666-1, and hknpc1) genomes were first resequ ... | 2014 | 24991008 |
| [epstein-barr virus infection with severe consequences. ebv, haemophagocytic lymphohistiocytosis and hodgkin lymphoma with down syndrome]. | over 90% of the population is infected with the epstein-barr virus (ebv). following primary infection, the virus remains latent in b-lymphocytes. in isolated cases, especially in immunocompromised patients, the epstein-barr virus can result in a chronic active infection (caebv). | 2014 | 24988166 |
| features of epstein-barr virus reactivation after allogeneic hematopoietic cell transplantation in korean children living in an area of high seroprevalence against epstein-barr virus. | the present study was conducted to investigate epstein-barr virus (ebv) reactivation after hematopoietic cell transplantation (hct) in korean children living in an area of a high seroprevalence against ebv and to determine the impact of recipient age on ebv reactivation. medical records of 248 children and adolescents who had received allogeneic hct were retrospectively reviewed. the trends of ebv reactivation and post-transplant lymphoproliferative disorders (ptlds) were evaluated and compared ... | 2014 | 24981711 |
| [lymphomatoid granulomatosis - the past and present]. | lymphomatoid granulomatosis (lyg) is a rare multisystemic angiocentric and angiodestructive b lymphoproliferative disease that was first described by liebow in 1972. disease was then in the "gray zone" between vasculitis and lymphoproliferative disease. lyg is currently categorized as a primary b lymphoproliferative disease associated with epstein-barr (eb) virus according to the world health organization (who) classification of tumours. epidemiology, clinical course and treatment: lymphomatoid ... | 2014 | 24981698 |
| identification and characterisation of the il-27 p28 subunits in fish: cloning and comparative expression analysis of two p28 paralogues in atlantic salmon salmo salar. | interleukin (il)-27 is an il-6/il-12 family member with pro-inflammatory and anti-inflammatory properties. it is a heterodimeric cytokine composed of an α-chain p28 and a β-chain ebi3 (epstein-barr virus induce gene 3). the p28 subunit can also be secreted as a monomer and function as il-30 that acts as an inhibitor of il-27 signalling. at present, the p28 gene has only been described in mammals. thus, for the first time outwith mammals, we have identified seven p28 molecules in six divergent te ... | 2014 | 24981291 |
| calcineurin inhibitor-free graft-versus-host disease prophylaxis with sirolimus and mycophenolate mofetil in a second allogeneic stem cell transplantation for engraftment failure and rituximab-refractory epstein-barr virus-induced posttransplant lymphoproliferative disease. | posttransplant lymphoproliferative disease (ptld) is a life-threatening complication after allogeneic hematopoietic stem cell transplantation. we describe here the case of a boy with history of induction failure of a t-cell acute lymphoblastic leukemia, who presented a life-threatening situation of nonengraftment and rituximab-refractory ptld after the first hematopoietic stem cell transplantation. we decided to use an unusual strategy of combining a nonmyeloablative conditioning (fludarabine an ... | 2014 | 24977404 |
| human interleukin-27: wide individual variation in plasma levels and complex inter-relationships with interleukin-17a. | although it is widely believed that interleukin (il)-27 is anti-inflammatory, its role in controlling human immune responses is not fully established. in particular, its interactions with t helper type 17 (th)17 cytokines are unclear. our aims were to establish the relationships between il-27 and proinflammatory cytokines, including il-17a, in human sera and cultures of peripheral blood mononuclear cells. plasma il-27 levels in 879 healthy humans from 163 families varied widely, but with relativ ... | 2014 | 24975574 |
| primary γδ t cell lymphoma of the lung: report of a case with features suggesting derivation from intraepithelial γδ t lymphocytes. | t cell lymphoma of γδ t cell origin is a rare disease that mainly involves extranodal sites and shows aggressive clinical behavior. here, we report a case of primary γδ t cell lymphoma of the lungs with epitheliotropism in the respiratory epithelium, a feature somewhat reminiscent of what is observed in enteropathy-associated t cell lymphoma. a 63-year-old man presented with chest pain and dyspnea on exertion, weight loss, and general weakness. on a positron emission tomography (pet) scan, multi ... | 2014 | 25027578 |
| clinico-pathological characteristics of different types of immunodeficiency-associated smooth muscle tumours. | rare epstein-barr virus (ebv)+ smooth muscle tumours (smt) manifest typically under immunosuppression. three major subtypes are known: human immunodeficiency virus-associated (hiv-smt), after transplantation (ptsmt) or associated with congenital immunodeficiency syndromes (ci-smt). so far, there are no analyses which compare the clinico-pathological characteristics of all three subtypes. case reports and case series on these three tumour types were collected (1990-2012). meta-data analysis was p ... | 2014 | 25027306 |
| evans syndrome after unrelated bone marrow transplantation for refractory cytopenia of childhood. | post-transplant es, which is often resistant to therapies, has seldom been described. this report describes a case of es after ubmt for rcc. a five-yr-old boy developed rcc with no evidence of monosomy 7. because no matching family donors were available for sct and immunosuppressive therapy was ineffective, ubmt was performed when he was six yr old. the conditioning regimen included tai (3 gy) and administration of flu, cy, and rabbit antithymocyte globulin. the recovery of blood cells was good. ... | 2014 | 25074497 |
| clinical outcome of epstein-barr virus-positive diffuse large b-cell lymphoma of the elderly in the rituximab era. | diffuse large b-cell lymphoma (dlbcl) is the most common subtype of malignant lymphoma. the incidence of epstein-barr virus (ebv)-positive dlbcl in asian and latin american countries ranges from 8 to 10%. the prognosis of patients with ebv-positive dlbcl is controversial. to compare the clinical outcome of ebv-positive and ebv-negative patients with dlbcl in the rituximab era, we analyzed 239 patients with de novo dlbcl diagnosed between january 2007 and december 2011. the presence of ebv in lym ... | 2014 | 24974976 |
| unexpected outbreak of epstein-barr virus post-transplantation lymphoproliferative disorder after hematopoietic stem cell transplantation conditioning with thymoglobulin. | 2014 | 24972250 | |
| malignancies associated with epstein-barr virus: pathobiology, clinical features, and evolving treatments. | epstein-barr virus (ebv) is associated with a wide variety of b-cell-derived lymphoid neoplasms, including burkitt lymphoma, lymphomas arising in immunocompromised patients (post-transplant and hiv-associated lymphomas), and hodgkin lymphoma. in addition, ebv has been linked to some t-cell lymphomas (angioimmunoblastic t-cell lymphoma, extranodal nasal-type natural killer/t-cell lymphoma, and other rare histotypes), nasopharyngeal cancer, and a subset of gastric cancers. advances in our understa ... | 2014 | 25003566 |
| a case of atypical hemolytic uremic syndrome. | a 9-year-old boy presented with fever not responding to antibiotic therapy and elevated blood urea and serum creatinine levels. the patient developed microangiopathic hemolytic anemia and thrombocytopenia during the hospital stay. kidney biopsy confirmed the diagnosis of atypical hemolytic uremic syndrome (hus). the patient had sufficient urine output, normal blood pressure, and no evidence of peripheral edema during the whole course of his disease. serum levels of anti-epstein-barr virus immuno ... | 2014 | 25001143 |
| epstein-barr virus-positive diffuse large b-cell lymphoma association is not only restricted to elderly patients. | diffuse large b-cell lymphoma (dlbcl), the most common group of malignant lymphomas, account for 30% of adult non-hodgkin lymphomas. the 2008 world health organization (who) classification included a new entity, epstein-barr virus (ebv)+ dlbcl of the elderly, affecting patients aged 50 years or older. however, some reports of younger ebv+ dlbcl cases, without evidence of underlying immunosuppression, can be found. the role of ebv in tumor microenvironment composition in dlbcl is still not well u ... | 2014 | 24789501 |
| expansion of murine gammaherpesvirus latently infected b cells requires t follicular help. | x linked lymphoproliferative disease (xlp) is an inherited immunodeficiency resulting from mutations in the gene encoding the slam associated protein (sap). one of the defining characteristics of xlp is extreme susceptibility to infection with epstein-barr virus (ebv), a gammaherpesvirus belonging to the genus lymphocryptovirus, often resulting in fatal infectious mononucleosis (fim). however, infection of sap deficient mice with the related murine gammaherpesvirus 68 (mhv68), a gammaherpesvirus ... | 2014 | 24789087 |
| establishment and maintenance of a pbmc repository for functional cellular studies in support of clinical vaccine trials. | a large repository of cryopreserved peripheral blood mononuclear cells (pbmcs) samples was created to provide laboratories testing the specimens from human immunodeficiency virus-1 (hiv-1) vaccine clinical trials the material for assay development, optimization, and validation. one hundred thirty-one pbmc samples were collected using leukapheresis procedure between 2007 and 2013 by the comprehensive t cell vaccine immune monitoring consortium core repository. the donors included 83 human immunod ... | 2014 | 24787274 |
| reversion of apoptotic resistance of tp53-mutated burkitt lymphoma b-cells to spindle poisons by exogenous activation of jnk and p38 map kinases. | defects in apoptosis are frequently the cause of cancer emergence, as well as cellular resistance to chemotherapy. these phenotypes may be due to mutations of the tumor suppressor tp53 gene. in this study, we examined the effect of various mitotic spindle poisons, including the new isocombretastatin derivative isonh2ca-4 (a tubulin-destabilizing molecule, considered to bind to the colchicine site by analogy with combretastatin a-4), on bl (burkitt lymphoma) cells. we found that resistance to spi ... | 2014 | 24787013 |
| regulation of epstein-barr virus reactivation from latency. | the epstein-barr virus (ebv) is a human gamma-herpesvirus that is implicated in various types of proliferative diseases. upon infection, it predominantly establishes latency in b cells and cannot ever be eradicated; it persists for the host's lifetime. reactivation of the virus from latency depends on expression of the viral immediate-early gene, bamhi z fragment leftward open reading frame 1 (bzlf1). the bzlf1 promoter normally exhibits only low basal activity but is activated in response to ch ... | 2014 | 24786491 |
| polymicrobial infection and bacterium-mediated epigenetic modification of dna tumor viruses contribute to pathogenesis. | abstract the human body plays host to a wide variety of microbes, commensal and pathogenic. in addition to interacting with their host, different microbes, such as bacteria and viruses, interact with each other, sometimes in ways that exacerbate disease. in particular, gene expression of a number of viruses, including kaposi's sarcoma-associated herpesvirus (kshv), epstein-barr virus (ebv), and human immunodeficiency virus (hiv), is known to be regulated by epigenetic modifications induced by ba ... | 2014 | 24781742 |
| genetic analysis of 17 children with hunter syndrome: identification and functional characterization of four novel mutations in the iduronate-2-sulfatase gene. | mucopolysaccharidosis type ii (mps ii) is a rare x-linked disorder caused by alterations in the iduronate-2-sulfatase (ids) gene. in this study, ids activity in peripheral mononuclear blood monocytes (pmbcs) was measured with a fluorimetric enzyme assay. urinary glycosaminoglycans (gags) were quantified using a colorimetric assay. all ids exons and intronic flanks were bidirectionally sequenced. a total of 15 mutations (all exonic region) were found in 17 mps ii patients. in this cohort of mps i ... | 2014 | 24780617 |
| epstein-barr virus-associated acute cholecystitis in a teenager. | a 14-year-old girl was admitted to hospital with fever, headache, sore throat and abdominal pain. her blood lymphocyte count and inflammatory markers were raised. acute epstein-barr virus (ebv) infection was suspected and confirmed serologically and by measuring the viral load. on day 7, she developed jaundice with abnormal liver function tests. an abdominal ultrasound scan revealed thickening of the gallbladder and bile duct walls without calculi suggesting acute acalculous cholecystitis. the p ... | 2014 | 27433206 |
| [characterization of bzlf1 gene and its promoter zp of ebv strains in children with ebv-associated diseases in recent 5 years in beijing area]. | this study aims to investigate the genetic characteristics of bzlf1 gene and its promoter zp of the epidemic strains in children with primary epstein-barr virus (ebv)-associated diseases. total dna was extracted from the peripheral blood of 134 children with ebv-associated infectious mononucleosis (ebv-im) and 32 children with ebv-associated hemophagocytic lymphohistiocytosis (ebv-hlh) who were admitted to beijing children's hospital from 2006 to 2011. the ebna3c, bzlf1, and zp genes were amplif ... | 2014 | 24772891 |
| autoverification in a core clinical chemistry laboratory at an academic medical center. | autoverification is a process of using computer-based rules to verify clinical laboratory test results without manual intervention. to date, there is little published data on the use of autoverification over the course of years in a clinical laboratory. we describe the evolution and application of autoverification in an academic medical center clinical chemistry core laboratory. | 2014 | 24843824 |
| deficiency of cd8+ effector memory t cells is an early and persistent feature of multiple sclerosis. | patients with multiple sclerosis (ms) have a deficiency of circulating cd8+ t cells, which might impair control of epstein-barr virus (ebv) and predispose to ms by allowing ebv-infected autoreactive b cells to accumulate in the central nervous system. based on the expression of cd45ra and cd62l, cd4+ t cells and cd8+ t cells can be subdivided into four subsets with distinct homing and functional properties, namely: naïve, central memory, effector memory (em) and effector memory re-expressing cd4 ... | 2014 | 24842963 |
| antibodies to epstein-barr virus and mri disease activity in multiple sclerosis. | previous reports indicate an association between epstein-barr virus (ebv) antibody levels and multiple sclerosis (ms) disease activity, but the results have been conflicting. | 2014 | 24842958 |
| asymptomatic post-transplant lymphoproliferative disorder diagnosed at one year protocol renal allograft biopsy. | post-transplant lymphoproliferative disorder (ptld) is a neoplastic complication with a potentially fatal outcome that develops as a consequence of immunosuppression, and is mainly associated with epstein-barr virus (ebv) infection. a 70-year-old woman underwent a live unrelated, abo-incompatible renal transplant for end-stage renal disease. one year after transplantation, protocol biopsy revealed pathological changes indicative of the histological subtype of 'early lesions of ptld' according to ... | 2014 | 24842822 |
| tobacco smoking increases immune activation and impairs t-cell function in hiv infected patients on antiretrovirals: a cross-sectional pilot study. | the influence of tobacco smoking on the immune system of hiv infected individuals is largely unknown. we investigated the impact of tobacco smoking on immune activation, microbial translocation, immune exhaustion and t-cell function in hiv infected individuals. | 2014 | 24842313 |
| primary cutaneous follicle center lymphoma with diffuse cd30 expression: a report of 4 cases of a rare variant. | cd30 is expressed in aggressive and epstein-barr virus-associated forms of b-cell non-hodgkin lymphomas, but is rarely expressed by the majority of tumor cells in primary cutaneous b-cell lymphomas (cbcls). the expression of cd30 in cbcls may be at risk for misinterpretation as an unequivocal indicator of a highly aggressive form of the disease. | 2014 | 24836545 |
| synergistic action of compounds isolated from the hexane extract of ardisia crispa root against tumour-promoting effect, in vitro. | an isomeric mixture of α,β-amyrin (triterpene) and 2-methoxy-6-undecyl-1,4-benzoquinone (quinone) isolated from the ardisia crispa root hexane (acrh) extract was reported to possess anti-inflammatory properties in vivo. considering the close association between inflammation and cancer, on top of the lack of antitumour study on those compounds, this study aimed to determine the potential of both compounds against tumour promotion in vitro, either as single agent or in combination. triterpene and ... | 2014 | 24836304 |
| smarcb1(ini1)-deficient sinonasal basaloid carcinoma: a novel member of the expanding family of smarcb1-deficient neoplasms. | poorly differentiated sinonasal carcinomas are a heterogenous group of aggressive neoplasms that encompasses squamous cell carcinoma including basaloid variant, lymphoepithelial carcinoma, sinonasal undifferentiated carcinoma, and neuroendocrine-type small cell carcinoma. we herein describe 3 cases of a hitherto unreported variant combining features of basaloid carcinoma with variable intermingled rhabdoid cells. patients were 2 women (aged 28 and 35) and a man (52 y) who presented with sinonasa ... | 2014 | 24832165 |
| clinicopathologic comparison of plasmablastic lymphoma in hiv-positive, immunocompetent, and posttransplant patients: single-center series of 25 cases and meta-analysis of 277 reported cases. | plasmablastic lymphoma (pbl) is a rare b-cell non-hodgkin lymphoma often associated with epstein-barr virus (ebv) infection. to gain insight in this aggressive lymphoma subtype, the clinicopathologic characteristics of 25 unpublished single-center pbls (2 in acquired immunodeficiency syndrome patients, 11 in immunocompetent individuals [ic-pbl], 12 in transplant recipients [pt-pbl]) and of 277 reported pbls were summarized. in the reported series, pbl patients were predominantly male (77%) with ... | 2014 | 24832164 |
| lymphoepithelial carcinoma of the salivary gland: morphologic patterns and imaging features on ct and mri. | lymphoepithelial carcinoma is a rare salivary gland lesion. we retrospectively reviewed ct and mr imaging features of salivary gland lymphoepithelial carcinoma to determine their imaging features and morphologic patterns. | 2014 | 24831594 |
| series of extranodal natural killer/t-cell lymphoma, nasal type, with periorbital involvement. | to describe the clinical presentation, diagnosis and treatment of periorbital extranodal natural killer/t-cell lymphoma, nasal type. | 2014 | 24831171 |
| identification of properties of the kaposi's sarcoma-associated herpesvirus latent origin of replication that are essential for the efficient establishment and maintenance of intact plasmids. | the maintenance of latent kaposi's sarcoma-associated herpesvirus (kshv) genomes is mediated in cis by their terminal repeats (tr). a kshv genome can have 16 to 50 copies of the 801-bp tr, each of which harbors a 71-bp-long minimal replicator element (mre). a single mre can support replication in transient assays, and the presence of as few as two trs appears to support establishment of kshv-derived plasmids. why then does kshv have such redundancy and heterogeneity in the number of trs? by dete ... | 2014 | 24829342 |
| a biocultural perspective on fictive kinship in the andes: social support and women's immune function in el alto, bolivia. | this article examines the influence of emotional and instrumental support on women's immune function, a biomarker of stress, in the city of el alto, bolivia. it tests the prediction that instrumental support is protective of immune function for women living in this marginal environment. qualitative and quantitative ethnographic methods were employed to assess perceived emotional and instrumental support and common sources of support; multiple linear regression analysis was used to model the rela ... | 2014 | 24824579 |
| primary ebv-positive hodgkin's lymphoma of the cns under azathioprine treatment: case report and review of the literature. | retrospective and prospective cohort studies suggest that central nervous system involvement occurs in approximately 0.5% of patients with advanced hodgkin's lymphoma. the isolated primary intracranial manifestation of hodgkin's lymphoma is an extremely rare finding, with few cases reported in the literature. little is known about the optimal treatment and prognosis of these tumors. here, we present a case report with a review of the literature. | 2014 | 24823896 |
| antiviral activity of topoisomerase ii catalytic inhibitors against epstein-barr virus. | herpesviruses require several cellular proteins for their lytic dna replication including topoisomerase ii (topo ii). thus, topo ii could be an effective drug target against herpesviral infection. in this study, we examined several topo ii catalytic inhibitors for their potentials in blocking ebv replication and becoming efficacious antiviral agents. topo ii catalytic inhibitors in general exhibited marked inhibition of ebv lytic replication and minimal cytotoxicity. in particular, (+)-rutamarin ... | 2014 | 24821256 |
| post-kidney transplant large bowel lymphoproliferative disorder. | epstein-barr virus (ebv)-associated post-transplant lymphoproliferative disorder (ptld) is a serious complication of organ transplantation. the gastrointestinal (gi) tract is a common site involved, but non-specific signs and symptoms often delay the diagnosis. we report a case of ebv-associated gi-ptld in a 68-year-old kidney transplant patient who received the kidney ten months earlier. he presented with chronic diarrhea and developed massive pneumo-peritoneum secondary to multiple colonic per ... | 2014 | 24821162 |
| age-specific prevalence of epstein-barr virus infection among minnesota children: effects of race/ethnicity and family environment. | primary epstein-barr virus (ebv) infection affects the host differently according to when in life it is acquired. understanding risk factors for infection could be important for disease prevention, and the age-specific prevalence of infection must be known to optimize use of a prophylactic vaccine. | 2014 | 24820696 |
| occurrence of epstein-barr virus-associated plasmacytic lymphoproliferative disorder after antithymocyte globulin therapy for aplastic anemia: a case report with review of the literature. | it is well established that patients with immunosuppression have a higher risk of development of lymphoproliferative disorders (lpds), and epstein-barr virus (ebv) is associated with development of lpds. aplastic anemia (aa) is an immune-mediated hematological disorder, and immunosuppression therapy (ist), such as antithymocyte globulin (atg), is widely used for treatment of aa. however, occurrence of lpd without bone marrow transplantation has been extremely rarely documented in patients with i ... | 2014 | 24817974 |
| diffuse alveolar damage in a patient with epstein barr virus (ebv)-positive diffuse large b-cell lymphoma,severely low serum folate, and megaloblastic anemia: a case report of autopsy. | we report a case of a 49-year-old japanese man, who was admitted to our hospital because of severe dyspnea. he was found to have severely low serum folate and megaloblastic anemia, which was at first suspected to cause his dyspnea. it was assumed that severely low serum folate might be related to his malnutrition, probably caused by habitual alcohol consumption. he died in several days because of acute respiratory distress syndrome. autopsy revealed diffuse alveolar damage (dad) in the lungs and ... | 2014 | 24817973 |
| metastatic cervical carcinoma from an unknown primary: literature review. | carcinoma of an unknown primary (cup) encompasses a heterogeneous group of tumors for which no primary site can be detected following a thorough history, physical examination, and noninvasive and invasive testing. cup presenting with metastasis to the neck (metastatic cervical carcinoma from an unknown primary [mccup]) has been an enigma since von volkmann first described it in 1882 as a cancer arising in a branchial cleft cyst. genetic studies have shed some light on this unusual entity. in mos ... | 2014 | 24817234 |
| stable dna methylation boundaries and expanded trinucleotide repeats: role of dna insertions. | the human genome segment upstream of the fmr1 (fragile x mental retardation 1) gene (xq27.3) contains several genetic signals, among them is a dna methylation boundary that is located 65-70 cpgs upstream of the cgg repeat. in fragile x syndrome (fxs), the boundary is lost, and the promoter is inactivated by methylation spreading. here we document boundary stability in spite of critical expansions of the cgg trinucleotide repeat in male or female premutation carriers and in high functioning males ... | 2014 | 24816393 |
| epstein-barr virus infection in adult renal transplant recipients. | epstein-barr virus (ebv) dnaemia in the first year posttransplantation has been studied extensively. there is a paucity of information on prevalence and sequelae of ebv infection in adult renal transplantation beyond the first year. this single-center study examines the relationship between ebv dnaemia and demographic, immunosuppressive, hematologic and infection-related parameters in 499 renal transplant recipients between 1 month and 33 years posttransplant. participants were tested repeatedly ... | 2014 | 24815922 |
| animal models of epstein barr virus infection. | epstein barr virus (ebv) was the first human tumor virus to be identified. despite 50years of research on this oncogenic virus, no therapeutic or prophylactic vaccine is available against this pathogen. in part, the development of such a vaccine is hampered by the lack of in vivo models for ebv infection and immune control. however, with the advent of mice with reconstituted human immune system components (his mice), certain aspects of ebv associated diseases and immune responses can be modeled ... | 2014 | 24815603 |
| multiple functions are mediated by the mirnas of epstein-barr virus. | epstein-barr virus is a gammaherpes virus that is causally associated with several malignancies and expresses multiple mirnas in both normal and tumor cells. since the identification of virally encoded mirnas, various mrnas have been identified as targets for regulation by ebv's mirnas in host cells. we shall summarize these targets, the robustness of their identification, and examine how the regulation of these targets by ebv contributes to the successful infection of its host. | 2014 | 24814666 |
| nasal type extranodal nk/t cell lymphoma diagnosed in a patient with rheumatoid arthritis under methotrexate. | rheumatoid arthritis (ra) patients have increased risk of lymphoma which seems associated mainly with high inflammatory state and disease activity, but also with immunosuppressive agents or epstein-barr virus (ebv) infection. many case reports describe lymphoproliferative lesions arising during methotrexate therapy, often ebv positive with possible regression after methotrexate withdrawal. the authors report the case of an 85-year-old patient with erosive and seronegative ra, in remission under ... | 2014 | 24811465 |
| methotrexate-associated lymphoproliferative disorder arising in the retromolar triangle and lung of a patient with rheumatoid arthritis. | we report an extremely rare case of massive methotrexate-associated lymphoproliferative disorder (mtx-lpd) arising in the retromolar triangle and lung of a patient with rheumatoid arthritis. the patient was a 75-year-old woman who was referred to our department because of severe pain associated with a unilateral ulcer on the left retromolar triangle. the tumor had an extranodal location in the retromolar triangle and in the right lung. a clinicopathologic examination found a lymphocytic infiltra ... | 2014 | 24811204 |
| oxysterol-ebi2 signaling in immune regulation and viral infection. | the seven transmembrane g protein-coupled receptor epstein-barr virus (ebv) induced gene 2 (ebi2; also known as gpr183) was identified in 1993 on the basis of its substantial upregulation in ebv-infected cells. it is primarily expressed in lymphoid cells; most abundantly in b cells. ebi2 is central for the positioning of b cells within the lymphoid organs, a process that is regulated in part by a chemotactic gradient formed by the endogenous lipid agonists, and in part by a fine-tuned regulation ... | 2014 | 24810762 |
| comparative evaluation of the new architect ebv assays considering different testing algorithms. | in the current evaluation, epstein-barr virus (ebv) serology was performed on 1113 routine serum samples. although the initial request for all samples from the general practitioner was ebv igm testing, 80.9% were classified as past infections. the architect(®) viral capsid antigen (vca) igm, vca igg, and ebv nuclear antigen (ebna) 1 igg assays showed good results for sensitivity and specificity, being 100.0%, 98.3%, and 100.0% and 99.9%, 95.4%, and 99.6%, respectively. using an algorithm based o ... | 2014 | 24809858 |
| epstein-barr virus down-regulates tumor suppressor dok1 expression. | the dok1 tumor suppressor gene encodes an adapter protein that acts as a negative regulator of several signaling pathways. we have previously reported that dok1 expression is up-regulated upon cellular stress, via the transcription factor e2f1, and down-regulated in a variety of human malignancies due to aberrant hypermethylation of its promoter. here we show that epstein barr virus (ebv) infection of primary human b-cells leads to the down-regulation of dok1 gene expression via the viral oncopr ... | 2014 | 24809689 |