Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| nucleoside analogs in treatment of chronic lymphocytic leukemia. | the nucleoside analogs fludarabine monophosphate, 2-chlorodeoxyadenosine, and 2-deoxycoformycin (pentostatin) all have activity in chronic lymphocytic leukemia. the most widely studied drug is fludarabine which is able to obtain complete or partial responses in more than 50% of previously treated patients. the response rate is 44% for 2-cda and approximately 25% for pentostatin. fludarabine has also been used to treat patients as initial therapy, and has resulted in overall response rate of 79% ... | 1993 | 8097653 |
| aerosolized pentamidine for primary prophylaxis of pneumocystis carinii pneumonia: a controlled, randomized trial. | the objective was to assess the efficacy of a biweekly dose of 60 mg aerosolized pentamidine (ap) for primary prophylaxis (pp) of pneumocystis carinii pneumonia (pcp) and the impact of prophylaxis on survival in hiv-infected patients. participants were aids patients with no history of pcp, patients with a cd4 count < or = 0.200 x 10(9)/l, or patients belonging to the cdc group ivc2, irrespective of cd4 count. it was an open, randomized, controlled trial. patients were assigned to receive ap, 60 ... | 1993 | 8097788 |
| pneumocystis carinii pneumonia after transsphenoidal removal of microadenoma causing cushing's syndrome. | 1993 | 8098477 | |
| prognostic factors of early fatal outcome and long-term survival in patients with pneumocystis carinii pneumonia and acquired immunodeficiency syndrome. | fifty-five episodes of pneumocystis carinii pneumonia (pcp) in aids patients were evaluated to assess clinical and laboratory risk factors predicting the probability of surviving the acute episode of pcp and the long-term survival after pcp. age > 45 yrs, pao2 < 50 mmhg, aapo2 > 50 mmhg, and ldh > 800 iu/l correlated strongly with early mortality; patients who needed mechanical ventilation had a significantly lower pao2 and serum albumin, and higher aapo2 and ldh compared to the patients who did ... | 1993 | 8100199 |
| pneumocystis carinii pneumonia during primary hiv-1 infection. | 3 patients with severe cd4 lymphocytopenia (62-91 cells/microl) and inverted cd4/cd8 ratios (0.13-0.15) developed pneumocystis carinii pneumonia during symptomatic, primary hiv-1 infection. within four months of symptom onset, their cd4 counts and cd4/cd8 ratios returned to normal. twenty-nine to forty-eight months after acquiring hiv-1 infection, they show no signs or symptoms of progression to aids. pneumocystis carinii pneumonia can occur, therefore, in primary hiv-1 infection, and profound c ... | 1993 | 8100292 |
| effect of routine use of therapy in slowing the clinical course of human immunodeficiency virus (hiv) infection in a population-based cohort. | clinical trials have shown that the prophylactic use of zidovudine and aerosolized pentamidine (or other antibiotics used as prophylaxis against pneumocystis carinii pneumonia) in acquired immunodeficiency syndrome (aids)-free human immunodeficiency virus (hiv)-infected persons delays the development of aids, but the effectiveness of such therapy in general use in the population still remains largely undocumented. to help answer this question, the authors estimate the effectiveness of this thera ... | 1993 | 8100682 |
| amount of pneumocystis carinii and degree of acute lung inflammation in hiv-associated p carinii pneumonia. | correlations between semiquantitative amounts of pneumocystis carinii (pc), the degree of inflammation, and the severity of pneumonia were analyzed in 58 patients with pc pneumonia (pcp). material from both transbronchial biopsies (tbbs; n = 39) and bronchoalveolar lavage fluid (balf; n = 57) was examined. in the tbb the amount of pc correlated strongly with overall inflammation in the interstitium (kendall correlation coefficient [kcc] = 0.59; p < 0.0001), type 2 pneumocyte proliferation, and e ... | 1993 | 8100757 |
| myopathy associated with human immunodeficiency virus infection: report of a case. | neuromuscular manifestations, including a variety of peripheral neuropathies and myopathies, can occur either as isolated clinical phenomena or concurrently with other clinical manifestations, and are common in acquired immunodeficiency syndrome (aids). a 33-year-old male patient had a four-year history of increasing proximal muscle weakness of the extremities. elevated muscle enzymes, a muscle biopsy and interstitial lung disease all suggested a diagnosis of polymyositis with lung involvement. ... | 1993 | 8101753 |
| a decline in the pulmonary diffusing capacity does not indicate opportunistic lung disease in asymptomatic persons infected with the human immunodeficiency virus. pulmonary complications of hiv infection study group. | we enrolled 1,353 subjects in a multicenter study to evaluate the spectrum of pulmonary complications associated with human immunodeficiency virus (hiv) infection and the feasibility of detecting pulmonary infections in asymptomatic members of this group. there were 1,171 who were hiv-seropositive; the remaining 182 were hiv-seronegative, but they belonged to high-risk transmission groups (homosexual/bisexual, or injection drug users). single-breath carbon monoxide diffusing capacity (dlco) was ... | 1993 | 8102043 |
| cholestatic hepatitis in children infected with the human immunodeficiency virus. | a distinct clinical syndrome of cholestasis and hepatitis occurred during early infancy in seven infants with perinatally acquired human immunodeficiency virus 1 infection. in five infants hepatitis was the first manifestation of human immunodeficiency virus 1 infection. the median age of onset of hepatitis was 7 months (range, 5 to 10 months). the mean total bilirubin concentration at presentation was 7.4 mg/dl (range, 3.9 to 11 mg/dl), the mean aspartate aminotransferase was 1512 iu/liter (ran ... | 1993 | 8102198 |
| case report: increase in cd4 lymphocyte counts after splenectomy in hiv-infected patients. | the records were reviewed of five human immunodeficiency virus (hiv) type 1-infected patients who underwent splenectomy, four for hiv-associated thrombocytopenia and one for gastric compression secondary to splenomegaly. after splenectomy, the four adult patients all had marked, sustained increases in their absolute cd4 lymphocyte counts; greater increases were observed in cd8 lymphocyte counts, accounting for decreases in the cd4:cd8 ratios. in patients 5 (one of triplets, all of whom were infe ... | 1993 | 8103284 |
| combined therapy in human immunodeficiency virus-infected children--a 4-year experience. | from 1988 to 1991 the long-term efficacy of a combined therapy with a polyvalent immunoglobulin/cytomegalovirus (cmv) hyperimmunoglobulin, oral low dose zidovudine, oral cotrimoxazole or inhaled pentamidine was investigated in three groups of human immunodeficiency virus (hiv)-infected children. group 1a consisted of three perinatally infected children with a cd4 cell decrease of > 400 cells/microliters per year. group 1b were 17 perinatally infected children with a cd4 cell decrease of < 400 ce ... | 1993 | 8104791 |
| pneumocystis carinii pneumonia in infants born to anti hiv positive mothers. | infants generally acquire hiv form mother during gestation, or delivery by contact with maternal blood and body fluids or breast feeding. at saraburi hospital, from january 1989 to december 1992, there were 17,766 mothers who gave birth, 80 anti hiv positive mothers were included. up to now, four cases of pcp have been reported in hiv infants born to anti hiv positive mothers at this hospital. all cases presented with symptoms of pneumonia and bilateral bronchopneumonia by chest x-ray. diagnosis ... | 1993 | 7964241 |
| latency is not an inevitable outcome of infection with pneumocystis carinii. | severe combined immunodeficiency (scid) mice resolve naturally acquired pneumocystis carinii pneumonia after reconstitution with immunocompetent spleen cells and can therefore be used as a model to study latent p. carinii infection. neither p. carinii nor amplified p. carinii dna was detected in the lungs of scid mice killed 21 days after spleen cell reconstitution. furthermore, scid mice that recovered from p. carinii infection failed to reactivate the infection after they were either depleted ... | 1993 | 7901169 |
| cd4+ lymphocyte response to zidovudine as a predictor of aids-free time and survival time. | it is unknown whether the early rise in cd4+ lymphocyte count seen in zidovudine-treated patients is associated with increased aids-free time and survival time. to determine the association of this and other changes in immunologic and hematologic markers with prognosis for time to aids and survival, we followed 747 aids-free patients from initiation of zidovudine therapy in the multicenter aids cohort study (macs). participants were seen semiannually and had data collected on medication use, imm ... | 1993 | 7901384 |
| epidemiology and infectious complications of human immunodeficiency virus antibody positive patients. | from july 1, 1991 to march 31, 1992, 156 patients (pts) with positive antibody titers to the human immunodeficiency virus (hiv) were seen in our clinic. a retrospective review of the epidemiology and infectious complications of these patients is presented. there were 129 males and 27 females (4.8:1, ratio). only 10/156 (12.8%) were non-whites (13 blacks and 7 hispanics). the majority, 126 (80.7%), were 25 to 44 years old. the most common risk factor was homosexuality or bisexuality 100 (64.1%), ... | 1993 | 7901972 |
| clinical manifestations of aids in the era of pneumocystis prophylaxis. multicenter aids cohort study. | among patients infected with human immunodeficiency virus type 1 (hiv-1), early and widespread use of prophylactic regimens against pneumocystis carinii is changing the pattern of illnesses related to the acquired immunodeficiency syndrome (aids). | 1993 | 7902536 |
| dietary micronutrient intake and risk of progression to acquired immunodeficiency syndrome (aids) in human immunodeficiency virus type 1 (hiv-1)-infected homosexual men. | the authors sought to determine if different levels of dietary intake of micronutrients are associated with the progression of human immunodeficiency virus type 1 (hiv-1) infection to acquired immunodeficiency syndrome (aids). a total of 281 hiv-1 seropositive homosexual/bisexual men were seen semiannually since 1984 at the baltimore/washington, dc site of the multicenter aids cohort study. participants completed a self-administered semiquantitative food frequency questionnaire at baseline. leve ... | 1993 | 7903021 |
| changes in survival after acquired immunodeficiency syndrome (aids): 1984-1991. | in a prospective cohort of 2,647 human immunodeficiency virus type 1 (hiv-1) seropositive homosexual men enrolled in baltimore, chicago, los angeles, and pittsburgh, 891 developed clinical acquired immunodeficiency syndrome (aids) between june 1984 and january 1992. cox proportional hazards models were used to examine temporal trends in survival after aids for specific diagnoses, controlling for level of immunosuppression at diagnosis, age, race, and geographic location. median survival time fol ... | 1993 | 7903022 |
| hypertrophic pulmonary osteoarthropathy associated with granulomatous pneumocystis carinii pneumonia in aids. | a case of hypertrophic pulmonary osteoarthropathy (hpoa) in a hiv-infected patient with granulomatous pneumocystis carinii pneumonia is described. this is the third case of hpoa associated with aids reported in the literature. granulomatous p. carinii pneumonia is an unusual manifestation of p. carinii infection. surgical treatment of this condition may lead to the dramatic spread of p. carinii causing a fulminant course with fatal outcome. | 1993 | 8052819 |
| [lupus erythematosus disseminatus and pneumocystis carinii pneumonia]. | we report a 49 years old woman with systemic lupus erythematosus and a who type iv nephropathy, treated with prednisone 1 mg/kg/day po and cyclophosphamide 1 g/month iv. after two months in this treatment schedule, she presented with an acute pneumonia; broncoalveolar lavage and lung biopsy disclosed the presence of pneumocystis carinii. she was treated with trimethoprim-sulfamethoxazole 960 mg tid with a favorable response. opportunistic infections are frequent in lupus erythematosus and pneumo ... | 1993 | 8085067 |
| cloning and characterization of the calmodulin-encoding gene from pneumocystis carinii. | complete cdna and genomic clones for the cam gene encoding calmodulin (cam) from pneumocystis carinii have been isolated from rat and characterized. the nucleotide (nt) sequence contains an open reading frame interrupted by three introns, that encodes a protein of 152 amino acids. the predicted cam protein of p. carinii shares a high degree of homology with other known cam proteins. | 1993 | 7916711 |
| [is the risk of pneumocystosis predictable in wegener's disease?]. | twelve cases of pneumocystis pneumonia in patients with wegener's granulomatosis were compared with a control-group of 32 patients. our study showed that the dose of cyclophosphamide received in the first three months and a profound lymphocytopenia were strongly predictive of a risk of pneumocystis carinii pneumonia in these patients. | 1993 | 8009021 |
| does experience improve hospital performance in treating patients with aids? | this paper examines how experience affects hospital performance in treating patients with aids. the most common life-threatening medical complication of aids is pneumocystis carinii pneumonia (pcp). studies of patients with pcp demonstrate that patients who received care at hospitals that were more experienced with aids had lower immediate mortality. these higher volume medical facilities did not use more resources but used resources more efficiently and provided better medical care. better outc ... | 1993 | 10125810 |
| neonatal disease induced by siv infection of the rhesus monkey (macaca mulatta). | seven 72-hr-old indian origin rhesus monkeys (macaca mulatta) were inoculated with 10 animal id50 of siv/deltab670. nine age-matched animals were used as uninoculated controls. all seven inoculated animals became infected as verified by viral isolation and siv p26 antigenemia. five of seven infected animals died within a mean of 31 days (range, 26-41 days), with high levels of antigenemia beginning 1-2 weeks postinoculation (pi) that persisted until death. absolute lymphocyte numbers were within ... | 1993 | 7508724 |
| direct monitoring as well as sensitive diagnosis of pneumocystis carinii pneumonia by the polymerase chain reaction on sputum samples. | in order to evaluate the usefulness of the polymerase chain reaction (pcr) for diagnosis and monitoring of pneumocystis carinii pneumonia (pcp) in specimens obtained from non-invasive techniques, expectorated or induced sputa were collected from 30 patients who were tentatively diagnosed as having pcp and administered intravenous trimethoprim-sulfamethoxazole. using appropriate criteria, 13 of these cases were diagnosed as having pcp, 12 cases were diagnosed of other pulmonary diseases, and five ... | 1993 | 7511788 |
| incidence and distribution of opportunistic lung infections in aids patients related to intravenous drug use: a study of bronchoalveolar lavage cytology by the diff-quik stain. | the present study was undertaken in order to determine the incidence and distribution of opportunistic lung infections in patients with acquired immunodeficiency syndrome related to intravenous drug use. one hundred ninety seven patients of both sexes were investigated. based on bronchoalveolar lavage cytology, a total of 156 (79%) patients were found to harbor opportunistic lung infections by the diff-quik staining procedure. seventy-nine percent of the males and 80% of the females were positiv ... | 1993 | 7507027 |
| [laboratory diagnosis of pneumocystis carinii: comparison of cytological, immunofluorescent and immunocytochemical staining]. | authors review several methods for diagnosis of pneumocystis carinii on bal fluid in aids patients aiming to identify ideal routine technic. giemsa, gomori and toluidine blue staining. direct and indirect immunofluorescence. immunocytochemical methods were tested and advantages/disadvantages compared on bal fluid from aids patients. pneumocystis carinii was detected in 7 out 21 cases (33%). gomori staining and toluidine blue staining were chosen for routine pneumocystis carinii detection while i ... | 1992 | 1279508 |
| phenotypic analysis of bronchoalveolar lavage lymphocytes from acquired immunodeficiency patients with and without pneumocystis carinii pneumonia. | a study was performed to reveal possible differences in lymphocyte subpopulations from bronchoalveolar lavage (bal) of acquired immunodeficiency patients with and without pneumocystis carinii pneumonia. forty-one consecutive human immunodeficiency virus-seropositive patients were studied. pneumocystis carinii infection was detected in the bal fluid from 18 patients. the bal lymphocyte subpopulations were determined by surface marker analysis with the immunoperoxidase slide assay. no significant ... | 1992 | 1280389 |
| purification of pneumocystis carinii trophozoites and identification of their circulating antigens. | we have developed a new method to isolate pneumocystis carinii trophozoites from experimental rat bronchoalveolar lavage specimens by using a percoll discontinuous gradient and have identified the circulating antigens in experimental rat p. carinii pneumonia. the antigenic components of the trophozoites were compared with those of cysts by immunoblotting. a major immunoreactive band of 90,000 da and some others of lower molecular mass were found in trophozoites. on the other hand, bands of 110,0 ... | 1992 | 1280653 |
| identification of a lectin activity in pneumocystis carinii. | pneumocystitis carinii is known to adhere to pulmonary alveolar epithelial cells in vivo and to epithelial cell lines in vitro by a mechanism unknown at the molecular level. p. carinii is now found to adhere to rabbit and human red blood cells leading to rosette formation and hemagglutination. p. carinii erythrocyte-adherence was best inhibited by bovine submaxillary mucin and by a polysaccharide from the wall of group a streptococcus, and to a lesser extent by streptococcus group c polysacchari ... | 1992 | 1281927 |
| treatment of aids-related non-hodgkin's lymphoma with a twelve week chemotherapy program. | current treatment options for acquired-immunodeficiency syndrome (aids)-related non-hodgkin's lymphoma (nhl) are unsatisfactory because of excessive toxicity rates and frequent recurrence of lymphoma. in this phase ii study, we evaluated a novel 12 week chemotherapy program with respect to feasibility, toxicity and therapeutic results. thirty hiv-seropositive patients with intermediate grade or small non-cleaved cell nhl received a 12 week program of weekly intravenous and oral chemotherapy cons ... | 1992 | 1283356 |
| [hiv infection: a case of progressive encephalopathy and pneumocystis carinii pneumonia in a child]. | 1992 | 1283713 | |
| [pneumocystis carinii infection in a hiv infection department]. | to determine the prevalence of pneumocystis carinii in the hiv-infection department, a simultaneous survey was made of 33 hiv-infected patients at various stages of the disease, of close relatives that were nursing the patients in the unit (n-7), and of medical staff of the department (n-20). patients with toxic infections who were on another floor of the same hospital and medical students were examined as a control group. for detection of p. carinii antigen, smears from the deep airways were te ... | 1992 | 1283714 |
| immunohistochemical detection of pneumocystis carinii in transbronchial lung biopsy specimens: antigen difference between human and rat pneumocystis carinii. | transbronchial lung biopsy specimens, from three patients with non-aids-related pneumocystis carinii pneumonia (pcp) and rat lung tissue in which pcp was induced by the administration of dexamethasone, were studied to determine the diagnostic usefulness of an immunohistochemical method using commercially available anti-pneumocystis monoclonal antibody, 3f6, on formalin-fixed, paraffin-embedded tissue. pc was consistently stained a bright red color and unambiguously identified in all three human ... | 1992 | 1283992 |
| [pneumocystis carinii pneumonia: laboratory diagnosis]. | we worked with 51 samples, 7 bronchoalveolar lavages (bal) and 44 sputa (s) of 31 aids patients with clinical and radiographic symptoms compatible with pneumocystis pneumonia. with the aim of finding a specific sensitive methodology for the diagnosis of pneumocystis carinii, we evaluated 4 coloration techniques (silver methenamine, its modification without gold chloride, toluidine blue and giemsa). 35% of the patients studied were positive. p. carinii were observed in 18% of the 44 sputa. we obs ... | 1992 | 1284318 |
| [differential diagnosis of ascites and abscess forming hepatitis in aids patients with reference to the first patient with microsporidia infection in austria]. | we report on a 30 years-old female aids patient suffering from generalized pneumocystosis and intestinal microsporidiosis. the chest x-ray showed a right-sided pleural effusion; the lungs showed no areas of consolidation and the heart and the vessels were normal in size. sonography revealed multiple cystic lesions of the liver measuring 1-3 cm in diameter, as well as ascites. pneumocystis carinii was detected on cytological examination of the bronchoalveolar lavage fluid, the pleural effusion an ... | 1992 | 1288019 |
| improvement of pulmonary gas exchange after surfactant replacement in rats with pneumocystis carinii pneumonia. | the effect of intratracheal surfactant instillation on pulmonary function in rats with pneumocystis carinii pneumonia (pcp) was investigated. in these animals which developed pcp with severe respiratory failure after s.c. administration of cortisone acetate over 8-12 weeks, pulmonary function could be improved by surfactant instillation, as measured by an increase in pao2. histological examination showed that alveoli of rats with pcp which received no surfactant treatment are filled with foamy e ... | 1992 | 1288089 |
| [a case of legionella pneumonia with myelodysplastic syndrome]. | a 40-year-old man was admitted with high fever and cough. pneumonic shadows of the left middle and lower lung fields increased rapidly, and his blood gases worsened. initial treatment with cefmenoxime, piperacillin, and minocycline was ineffective. administration of rifampicin was started for suspected legionella pneumonia, but it did not control the spread of the pneumonia shadows. after addition of an antifungal agent and trimethoprim-sulfamethoxazole, his symptoms gradually improved. isolatio ... | 1992 | 1289632 |
| high dose aerosol pentamidine for secondary pneumocystis carinii pneumonia prophylaxis in aids patients. | in a prospective trial of aerosolized pentamidine as secondary prophylaxis for pneumocystis carinii pneumonia (pcp) 18 patients received 400 mg once weekly for a mean period of 15.5 months. pentamidine aerosol was administered with an ma2 jet nebulizer. no pcp relapses were observed and no serious side effects occurred. | 1992 | 1293048 |
| [infectious complications in patients with adult t-cell leukemia]. | between january, 1982, and january, 1992, a total of 112 patients with adult t-cell leukemia (atl) and 109 patients with non-hodgkin's lymphoma (nhl) were admitted to our hospital. they were studied for their infectious complications. infectious complications were seen in 90 patients (80.4%) with atl, and 51 patients (46.8%) with nhl (p < 0.001). documented infections were seen in 70 patients (62.5%) with atl, and 30 patients (27.5%) with nhl (p < 0.001). pneumonia (p < 0.005), skin infections ( ... | 1992 | 1293224 |
| acquired immunodeficiency syndrome (aids) with lymphocytic interstitial pneumonitis (lip) in a multi transfused child with thalassemia major. | the case of a 10.5-year-old girl, who was diagnosed with a case of thalassemia major at the age of 8 months and had been on regular blood transfusions since then, is related. donor screening for hiv was started in mid-1988, thus she had received unscreened blood for a number of years. in february 1991, she presented with a dry persistent cough, moderate grade continuous fever, and breathlessness on exertion for over 2 weeks. chest x-ray showed bilateral infiltrations. she was put on penicill ... | 1992 | 1294497 |
| [human lymphocyte proliferative response and gamma-interferon production to pneumocystis carinii antigen in vitro]. | in vitro proliferative response and gamma-interferon (ifn-gamma) production to pneumocystis carinii antigen were investigated in peripheral blood mononuclear cells (pbmc) from healthy volunteers and cord blood mononuclear cells (cbmc) from umbilical cords after delivery. twenty three of 25 samples of pbmc had strong proliferative response, and 15 of 25 samples of pbmc produced ifn-gamma. in the samples showing strong proliferative response, cd4 lymphocytes expressed interleukin 2 receptors. none ... | 1992 | 1294671 |
| [pneumocystis carinii pneumonia in a kidney transplantation center in the proximity of an aids care unit]. | 1992 | 1297138 | |
| susceptibility of various animals to pneumocystis carinii infection. | pneumocystis carinii (pc) is an important opportunistic pathogen of immune compromised hosts, and is known to infect various animals. the present study observed the infection status of 6 mammals and 3 strains of albino rats with pc after suppression of their immunity. methyl-prednisolone was injected once a week and tetracycline was supplied with water for 5 to 21 weeks. hamsters, guinea pigs, rabbits, dogs, cats and pigs were negative by impression smear, and only the rats were found infected b ... | 1992 | 1297418 |
| transmission modes of pneumocystis carinii among rats observed by karyotype analysis. | to observe the transmission patterns of karyotype of pneumocystis carinii (pc) by rat colonies, three strains of rats, sprague-dawley(sd), wistar(w) and fisher(f) from various animal vendors, were suppressed of their immunity by injection of methyl prednisolone. they were kept for 5 to 13 weeks in 3 different animal rooms, a, b, and c. the purified organisms were prepared in low melting point agarose gel by embedded lysis method for pulsed field gel electrophoresis. field inversion gel electroph ... | 1992 | 1297419 |
| [liver transplant in childhood: our experience]. | from december 1984 to december of 1991, 12 children underwent on orthotopic liver transplantation (olt): 6 had extrahepatic biliary atresia (ehba), 2 had byler disease, 2 hepatocellular carcinoma (hcc), 1 alagille syndrome and 1 had a hyperacute wilson disease. the children, transplanted for the most part a broad, return for observation 3 months after olt. a patient with hyperacute wilson's disease had 2 emergency olts and died of sepsis (due to aspergillus); another with ehba, operated for hepa ... | 1992 | 1298933 |
| [the pulmonary manifestations in aids]. | clinical and paraclinical experience in hiv infection, though the time elapsed since the first observations is relatively short, begins to get typical outlines. in the case of aids, the lung is the main place of opportunistic infections, other inflammatory processes and neoplasia. the present work deals with six clinical cases with positive serum tests for hiv and secondary respiratory phenomena such as: kaposi sarcoma, pneumonia with pneumocystis carinii, tuberculosis, candidosis, pneumonia wit ... | 1992 | 1299394 |
| pneumocystis carinii pneumonia in patients with systemic lupus erythematosus. | at the university hospital, kuala lumpur, malaysia, nine patients with systemic lupus erythematosus (sle) were treated for pneumocystis carinii pneumonia (pcp) between january 1987 and december 1988. when they developed pcp all the patients' sle disease course was active and eight of them were on prednisolone. four of these eight patients were also receiving cyclophosphamide. patients who were on more intensive immunosuppressive therapy were found to develop more severe pcp. all the patients exc ... | 1992 | 1304406 |
| [isolation and purification of pneumocystis carinii cyst]. | twenty wistar rats were injected with cortisone acetate twice a week subcutaneously for 6-12 wks. by 7 weeks pneumocystis carinii pneumonia was induced in rats successfully. the cysts of pneumocystis carinii from infected lungs of cortisonized rats were identified by phase-contrast microscopy, giemsa's stain, chalvardjian's stain and gomori's methenamine silver nitrate stain. the process of isolation and purification of pneumocystis carinii from infected rat lungs included the following three te ... | 1992 | 1307267 |
| pneumocystis carinii pneumonia prophylaxis: past, present and future. | 1992 | 1307680 | |
| patients' perceptions of pulmonary problems and nursing interventions during hospitalization for pneumocystis carinii pneumonia. | the descriptive, correlational study examined patients' perceptions of pulmonary problems and nursing interventions in a sample (n = 201) of persons living with aids hospitalized for pneumocystis carinii. additionally, the study assessed differences in physiological variables, patient symptoms, and functional status based on the type of problems identified: dyspnea, pulmonary problems without dyspnea, and nonpulmonary problems. | 1992 | 1307871 |
| pneumocystis carinii pneumonia (pcp) in a renal transplant recipient in india. | 1992 | 1308040 | |
| chemotherapy and immunity in opportunistic parasitic infections in aids. | parasitic diseases are endemic in parts of the tropics, but there is no convincing evidence that their prevalence or incidence is increasing due to the hiv epidemic. available scientific data on parasitic infections in patients with the acquired immunodeficiency syndrome (aids) suggests a predominance of pneumocystis carinii, toxoplasma gondii and cryptosporidium spp. for reasons which are unclear, parasitic infections such as plasmodium falciparum, strongyloides stercoralis and entamoeba histol ... | 1992 | 1308934 |
| impact of pneumocystis carinii and cytomegalovirus on the course and outcome of atypical pneumonia in advanced human immunodeficiency virus disease. | patients undergoing bronchoscopy for possible pneumocystis pneumonia were studied retrospectively to characterize the impact of common viral pathogens on the course of advanced human immunodeficiency virus (hiv) disease and atypical pneumonia. in 327 episodes, pneumocystis carinii was found in 220 (67%), cytomegalovirus (cmv) in 145 (44%), and herpes simplex virus in 16 (5%). early deterioration in oxygenation and use of intensive care was less common in cmv-positive patients. neither cmv nor p. ... | 1992 | 1309375 |
| pneumocystis carinii pneumonia. an uncommon cause of death in african patients with acquired immunodeficiency syndrome. | admissions and deaths in a pulmonary medicine ward in abidjan, cote d'ivoire, west africa, were evaluated over a 6-month period in 1989 with systematic autopsies on all patients who died. of 473 patients admitted, 38% were hiv-1 seropositive, 4% were hiv-2 seropositive, and 14% reacted to both viruses. a total of 100 patients (21%) died, and deaths were twice as frequent in hiv-seropositive compared with hiv-negative patients. the pathology of 78 autopsies showed that the predominant cause of de ... | 1992 | 1312314 |
| apparent retrovirus-induced immunosuppression in a yearling llama. | immunosuppression suspected to be associated with retrovirus infection was diagnosed in an 18-month-old female llama. the llama had a 6-month history of weight loss, intermittent lameness, and infections that were nonresponsive to treatment. serial cbc indicated persistent nonregenerative anemia and leukopenia characterized by absolute neutropenia and lymphopenia. functional hypoplasia of myeloid and erythroid cell lines was detected in serial bone marrow biopsy specimens. notable pathologic fin ... | 1992 | 1312520 |
| postoperative respiratory failure secondary to pneumocystis carinii pneumonia. | pneumocystis carinii pneumonia (pcp) occurs frequently in individuals infected with the hiv virus. malignancy, immunosuppressive drugs, and congenital immune deficiency may be associated with pcp. we describe a patient with stage 1 testicular carcinoma who developed hypoxemic respiratory failure two days after retroperitoneal lymph node dissection. pneumocystis carinii organisms were demonstrated by catheter lavage samples and confirmed on bronchoalveolar lavage. testing for hiv antibody by elis ... | 1992 | 1313351 |
| the multifunctional folic acid synthesis fas gene of pneumocystis carinii appears to encode dihydropteroate synthase and hydroxymethyldihydropterin pyrophosphokinase. | we describe the cloning of a multifunctional folic acid synthesis (fas) gene from pneumocystis carinii. the nucleotide sequence contains an open reading frame interrupted by three introns, that encodes a protein of 740 amino acids with an mr of 97,278. the predicted fas protein has homology to two enzyme domains, dihydropteroate synthase and 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, both of which are involved in folate synthesis, and at least one other region of unknown function. | 1992 | 1313386 |
| interactions and toxicities of drugs used in patients with aids. | as clinicians have come to realize, patients who have aids are uniquely predisposed to drug-associated toxic effects and allergic reactions. in san francisco general hospital's first clinical trial involving patients with pneumonia due to pneumocystis carinii, only one-third of all patients who were treated initially with either trimethoprim-sulfamethoxazole or pentamidine were able to complete the 3-week course. because of drug-related toxic effects, most patients required an alteration in ther ... | 1992 | 1314104 |
| gastric uptake of gallium-67 in aids. | we describe gastric localization of 67ga in 13 patients with acquired immunodeficiency syndrome (aids) among 148 referred primarily to rule out pneumocystis carinii pneumonia (pcp). endoscopic biopsies in five of the patients indicated cytomegalovirus (cmv) infection in one, gastritis in two, and normal tissue in two. other associated, but nongastric, infections in these 13 patients included esophageal candidiasis, pcp, mycobacterium avium-intracellulare (mai) complex, coccidioidomycosis, toxopl ... | 1992 | 1314894 |
| lack of clinical evidence for a specific hiv-associated glomerulopathy in 203 patients with hiv infection. | several authors described a high incidence of proteinuria with frequent progression to nephrotic syndrome and/or renal failure in patients with hiv infection. though renal histological changes were rather non-specific, the existence of a specific, hiv-associated glomerulopathy was postulated. we repeatedly investigated proteinuria and serum creatinine in 203 hiv-infected patients. one hundred and twenty-two patients (group 1) had early stages of the disease without opportunistic infections, 81 s ... | 1992 | 1314985 |
| cytomegalovirus and pneumocystis carinii pneumonia in children with acquired immunodeficiency syndrome. | to ascertain the effect of cytomegalovirus (cmv) infection on the course of pneumocystis carinii pneumonia (pcp) in children with acquired immunodeficiency syndrome (aids), we reviewed the charts of all children with aids who also had a lung biopsy specimen or a bronchoalveolar lavage specimen cultured for cmv at the time pcp was diagnosed. the data indicate that children with aids and pcp whose cultures are positive for cmv do not have a poorer prognosis during a first episode of pcp compared w ... | 1992 | 1317421 |
| disseminated pneumocystis carinii infection in a hemophiliac patient with acquired immunodeficiency syndrome. | a case of disseminated pneumocystis carinii (pc) infection in a 28-year-old japanese male hemophiliac with acquired immunodeficiency syndrome (aids) is reported. the patient had displayed a high fever and diffuse faint interstitial infiltrates on chest x-ray films without dyspnea three months before his death. at that time, no pc was detected after four consecutive induced sputum tests. serum anti-cytomegalovirus (cmv) igm was positive by eia. no treatment for pc and cmv was given at the patient ... | 1992 | 1319101 |
| cytomegalovirus gastritis: protean radiologic features. | infection with cytomegalovirus (cmv) is a major feature of acquired immunodeficiency syndrome (aids). gastrointestinal involvement is being seen more frequently. our collective experience involves nine patients with stomach involvement. seven patients were intravenous drug abusers or homosexuals with aids. one developed cmv gastritis as a complication of leukemia and one patient was a west african with lymphoma and human immunodeficiency virus (hiv) infection. all our patients had biopsy-proven ... | 1992 | 1319363 |
| cdc releases recommendations for prophylaxis against pneumocystis carinii pneumonia. | 1992 | 1320326 | |
| [pulmonary complications in patients with adult t-cell leukemia]. | in order to investigate the character of pulmonary complications in patients with adult t-cell leukemia (atl), a pathological and bacteriological study was performed in 92 autopsy cases with hematologic malignancies including 17 cases of atl and 103 autopsy cases with solid malignancies from 1981 to 1990. among 17 cases with atl, pulmonary complications were seen in 16 cases (94.1%); pulmonary infection in 14 (82.3%), leukemic cell pulmonary infiltration in 9 (52.9%), pulmonary hemorrhage in 5 ( ... | 1992 | 1321303 |
| dual infection with pneumocystis carinii and respiratory viruses complicating bone marrow transplantation. | pneumonia due to dual infection with pneumocystis carinii and respiratory viruses is a rare but formidable complication of bone marrow transplantation. we report here two cases of viral infections complicating p. carinii pneumonia in bone marrow transplant recipients who, at the time of infection, were not taking p. carinii prophylaxis. both patients died following the pneumonia. potential factors contributing to the dual infection included graft-versus-host disease, high-dose steroids and cyclo ... | 1992 | 1324758 |
| subclinical pneumonitis due to pneumocystis carinii in a young adult with elevated antibody titers to epstein-barr virus. | pneumocystis carinii was recovered from the lungs of a 20-year-old woman in apparent good health who had volunteered to undergo bronchoalveolar lavage (bal) as a normal control subject. total and differential cell counts in the bal fluid revealed a significantly increased number and proportion of t lymphocytes, although the cd4:cd8 ratio was in the normal range. despite the lack of specific antibiotic therapy, in a subsequent lavage no p. carinii were recovered, and the total and differential ce ... | 1992 | 1326586 |
| [the respiratory manifestations of the acquired immunodeficiency syndrome in children]. | the authors present the pulmonary complications (infectious and non infectious) in children with aids. it is shown that in this group of children the pulmonary complications are the first cause of death, and among them, the most frequent are the interstitial lymphoid pneumonia and pneumocystis carinii pneumonia. | 1992 | 1327217 |
| pneumocystis carinii pneumonia associated with solid ectopic corticotropin-producing tumors. | 1992 | 1329696 | |
| cytomegalovirus infections in heart transplant recipients: relationship to immunosuppression. | to determine the relationship of cytomegalovirus infections (cmvi) to immunosuppression in heart transplants, we retrospectively compared demographic and clinical variables in 154 consecutive heart transplant patients. forty-one cmvi were compared; of these, 30 (73%) were identified in tissue, and nine (22%) were identified by blood or urine culture. twenty (49%) of the cmvi were self-limited, and 21 (51%) were progressive, requiring treatment. when comparing patients with and without cmvi, demo ... | 1992 | 1329959 |
| [laboratory diagnosis of cytomegalovirus infections and pneumocystis carinii pneumonia in immunosuppressed patients]. | 1992 | 1334217 | |
| [incidence, prevention and therapy of cytomegalovirus and pneumocystis carinii infection after heart transplantation]. | diseases caused by cytomegalovirus (cmv) and pneumonia due to pneumocytis carinii (pcp) are problematic complications after allogeneic heart transplantation. recipients of cmv-seropositive donors have a higher morbidity of cmv. by using an anti-cmv-immunoglobulin preparation in routine prophylaxis the incidence of cmv disease after heart transplantation could be reduced significantly. ganciclovir 10 mg/kg is administered for treatment of cmv disease for at least 14 days. recent investigations sh ... | 1992 | 1334222 |
| [incidence, prevention and therapy of cytomegalovirus and pneumocystis carinii pneumonia after liver transplantation]. | 1992 | 1334223 | |
| aids-defining diseases in 250 hiv-infected patients; a comparative study of clinical and autopsy diagnoses. | to evaluate the correlation between clinical and autopsy findings in 250 aids patients. | 1992 | 1334675 |
| [rapid diagnosis of cytomegalovirus pneumonia and pneumocystis carinii pneumonia by using polymerase chain reaction dna amplification]. | we attempted to detect cytomegalovirus dna (cmv-dna) and pneumocystis carinii dna (carinii-dna) in urine, blood and sputum samples of 16 leukemia patients with pneumonia, using the polymerase chain reaction (pcr). synthetic oligonucleotide primer pair were used to amplify dna from the major immediately genes of cmv and genes for the large subunit of mitochondrial ribosomal rna of p. carinii. amplified products were detected by gel electrophoresis. in two cases, cmv-dna was detected at about the ... | 1992 | 1338207 |
| fungus-specific translation elongation factor 3 gene present in pneumocystis carinii. | historically, pneumocystis carinii pneumonia has been the most frequent cause of morbidity and mortality in patients with aids. antiprotozoan drugs are effective in the treatment and prophylaxis of p. carinii pneumonia, which lends credence to the widely held view that p. carinii is a protozoan. however, recent genetic evidence suggests that p. carinii should be classified as a fungus. translation elongation factor 3 (ef-3) is an essential, soluble translation component which is unique to fungal ... | 1992 | 1339410 |
| [infectious complications of heart-lung transplantation]. | this study describes the infectious complications in 68 heart-lung transplant patients. we focused interest on early post-transplant infections so called nosocomial pulmonary infections, their exacerbating cofactors their clinical expression, and elements of diagnosis and treatment. furthermore we describe the principal infections seen during long-term followup, which are opportunist infections caused most often by immunosuppression: cytomegalovirus infections have a high incidence with serious ... | 1992 | 1340092 |
| detection of pneumocystis carinii in bronchoalveolar lavage fluid by dot immunobinding assay and immunofluorescence. | 1992 | 1341210 | |
| production and characterization of monoclonal antibodies to human pneumocystis carinii for the diagnosis of p. carinii pneumonia. | monoclonal antibodies against human pneumocystis carinii were produced by fusion of myeloma cells (x63-ag8.653) with splenocytes from biozzi mice that had been immunized against p. carinii cysts isolated from infected human lung. the aim of this study was to evaluate the usefulness of these monoclonal antibodies for the diagnosis of p. carinii pneumonia by indirect immunofluorescence in comparison with a modified silver stain method and commercial kits. | 1992 | 1341432 |
| [pneumocystis carinii infection. various aspects on its clinical and laboratory diagnosis]. | p carinii is an opportunistic pathogenic agent able to produce severe infection that must be diagnosed promptly. we analyzed 138 samples from 100 patients suspected of having infection by p carinii. the ortho-toluidine blue and the methenamine stains were used to analyze the samples. infection was demonstrated in 18 patients, 13 adults and 5 children. underlying disease was aids in 7 and other immunosuppressive disorders in the rest. no immunocompetent patient was infected with p carinii. proper ... | 1992 | 1341792 |
| [paracoccidioides brasiliensis (lutz, 1908) isolated by hemoculture in a patient with the acquired immunodeficiency syndrome (aids)]. | a case of an aids patient with positive blood culture for paracoccidiodes brasiliensis is reported. the patient was a 29-years-old male born in nova londrina (paraná state, brazil) who presented splenomegaly and fever of unknown origin. three blood cultures were performed, each one of them for aerobic bacteria, mycobacteria and fungi. cultures for aerobic bacteria and mycobacteria were negative. however, the yeast phase p. brasiliensis was isolated from two cultures in bhi agar, 20 days after in ... | 1992 | 1342126 |
| [japanese clinical statistical data of patients with pneumocystis carinii pneumonia]. | 1992 | 1344377 | |
| [pediatric aids: a report of the first fatal cuban pediatric case]. | the case of a cuban child with aids acquired by perinatal transmission is reported. thirteen days after birth, the child had chronic diarrhoeas affecting its pondostatural development. it was hospitalized many times due to recurrent respiratory processes, in one of which pneumocystis carinii was detected. oral candidiasis, cryptosporidiosis and intestinal amebiasis in faeces were also diagnosed. it died with generalized tonic-clonic convulsions and bradypnea. at autopsy, the direct death cause w ... | 1992 | 1344687 |
| [infections and other opportunistic processes in a group of cuban stage-iv hiv patients]. | forty cuban patients affected by the human immunodeficiency virus (hiv), belonging to group iv, assisted during a year at the pedro kourí tropical medicine institute, are reported. pneumocystis carinii, cryptosporidiosis, mucocutaneous herpes simplex, oral candidiasis and multidermatoma herpes zoster were the most commonly found infections. other non-opportunistic diseases such as dermatitis seborrhoeica and onychomycosis were also present. | 1992 | 1344688 |
| pneumocystis carinii infection complicating cytotoxic therapy in two patients with lymphopenia, but a normal total white cell count. | 1992 | 1346096 | |
| drug interactions in use of dapsone for pneumocystis carinii prophylaxis. | 1992 | 1347616 | |
| seasonal variation in presentation of pneumocystis carinii pneumonia. | 1992 | 1347618 | |
| the effects on survival of early treatment of human immunodeficiency virus infection. | zidovudine has been shown to prolong survival in patients with the acquired immunodeficiency syndrome (aids) and, in persons with human immunodeficiency virus (hiv) infection but not aids, to delay the progression to aids. however, it is still uncertain whether treatment before the development of aids prolongs survival. | 1992 | 1347907 |
| outpatient management of patients infected with human immunodeficiency virus. | the outpatient management of patients infected with human immunodeficiency syndrome is reviewed. patients with cd4+ cell counts of greater than 0.5 x 10(9)/l (500/mm3) require no specific intervention except vaccination against influenza, pneumococcus, and possibly hepatitis b. they should have a follow-up examination every 3 to 6 months. because of its success in preventing the progression of the disease, zidovudine (azt), 100 mg five times per day, is recommended for patients with cd4+ cell co ... | 1992 | 1348266 |
| from the centers for disease control. recommendations for prophylaxis against pneumocystis carinii pneumonia for adults and adolescents infected with hiv. | 1992 | 1348788 | |
| recommendations for prophylaxis against pneumocystis carinii pneumonia for adults and adolescents infected with human immunodeficiency virus. | in 1989, the united states public health service convened a task force of experts to consider the expanding knowledge base about prevention of pneumocystis carinii pneumonia (pcp) among adults and adolescents (greater than or equal to 13 years of age) with human immunodeficiency virus (hiv) infection. this task force concluded that the morbidity, mortality, and cost due to pcp could be substantially reduced by appropriate use of antipneumocystis prophylaxis in subgroups of hiv-infected patients ... | 1992 | 1348843 |
| seasonal incidence of pneumocystis carinii pneumonia. | 1992 | 1349413 | |
| comparison of nebuliser efficiency for aerosolizing pentamidine. | inhaled pentamidine has become an important method of treatment and prophylaxis for pneumocystis carinii pneumonia and we have compared nebuliser efficiency in terms of drug output and droplet sizes in four brands of jet nebuliser (acorn-22, inspiron, cirrus, respirgard ii) and one brand of ultrasonic nebuliser (fisoneb), at 2 pentamidine concentrations and 3 flow rates, using a laser particle sizer. droplet size (which varied from 1.2 to 4.7 microns mass median diameter) was dependent in all ca ... | 1992 | 1350636 |
| prophylaxis for pneumocystis carinii pneumonia in patients infected with human immunodeficiency virus. | following the initial observation by dr. margaret fischl that trimethoprim-sulfamethoxazole can prevent pneumocystis carinii infection in patients with kaposi's sarcoma, initiating prophylaxis for pneumocystic infection in all patients with less than 200 cd4+ cells/mm3 has become accepted practice. this prophylactic intervention has been found not only to reduce the development of pneumonia due to p. carinii but also to prolong life. drs. henry masur and joseph a. kovacs first reviewed prophylax ... | 1992 | 1350925 |
| low-dose trimethoprim-sulfamethoxazole prophylaxis for toxoplasmic encephalitis in patients with aids. | to determine the efficacy of low-dose trimethoprim-sulfamethoxazole (trimethoprim, 160 mg plus sulfamethoxazole, 800 mg; one tablet twice daily, 2 days per week) as primary prophylaxis against toxoplasmic encephalitis in patients with human immunodeficiency virus (hiv) infection and previous pneumocystis carinii pneumonia. | 1992 | 1351371 |
| optimal management strategies for hiv-infected patients who present with cough or dyspnea: a cost-effective analysis. | to determine the effectiveness and costs of alternative management strategies for patients infected with the human immunodeficiency virus (hiv) who present with pulmonary symptoms. | 1992 | 1351940 |
| changes in the spectrum of aids-defining conditions and decrease in cd4+ lymphocyte counts at aids manifestation in germany from 1986 to 1991. | analysis of changes in the spectrum of aids-defining conditions and their correlation with cd4+ lymphocyte counts in different risk groups associated with hiv transmission. | 1992 | 1352106 |
| improved diagnosis of pneumocystis carinii infection by polymerase chain reaction on induced sputum and blood. | detection of pneumocystis carinii by the polymerase chain reaction (pcr) may facilitate non-invasive diagnosis of p carinii pneumonia and study of its epidemiology. we have compared the sensitivity and specificity of two pcr methods with those of conventional staining for detection of p carinii in induced sputum, bronchoalveolar lavage fluid (bal), and blood. of 71 sputum samples, 17 were from patients with microbiologically confirmed p carinii pneumonia. a nested pcr method correctly identified ... | 1992 | 1353136 |