Publications

the effect of corynebacterium parvum in combination with 5-fluorouracil, l-phenylalanine mustard, or methotrexate on the inhibition of tumor growth.	previous reports from this laboratory have demonstrated conclusively that cyclophosphamide administered asynchronously with corynebacterium parvum (cp) results in greater c3h mammary tumor inhibition than that observed with either agent alone. an analysis of this combination has revelaed that the chemotherapeutic component contributes more significantly to tumor inhibition than does the immunotherapeutic one. this study was conducted to investigate the inhibition of c3h mammary tumors by other c ...	1976	1277181
further observations on the diagnosis cause, and treatment of endophthalmitis.	in our study of 54 suspected cases of endophthalmitis, vitreous aspiration was more sensitive in making a culture-proven diagnosis than anterior chamber paracentesis; staphylococcus epidermidis was a more common cause of endophthalmitis than previously appreciated; and intraocular antibiotics in the recommended dosage are reasonably safe clinically and add a new dimension to the treatment of endophthalmitis.	1976	1082716
immunotherapy: concepts and nursing implications.	concepts of immunlogy and the human immune system are essential for an understanding of the rationale of immunotherapy. immunotherapy is presently being investigated as adjunct therapy for patients with cancer. it is therefore essential for the professional nurse to become cognizant of the various modalities and possible complications of immunotherapy in order that the nursing implications may be incorporated into clinical practice.	1976	1083016
the accumulated effects of repeated systemic or local injections of low doses of corynebacterium parvum in mice.	the effects of 14 weekly injections, s.c. or i.v., of "human equivalent" doses (5.25 mg/sq m) of corynebacterium parvum (cp) in mice have been compared. both s.c. and i.v. cp caused significant splenomegaly and antibody to cp, but stimulation was considerably greater after i.v. cp. delayed hypersensitivity levels to cp were similar after s.c. and i.v. injection. t-cell competence, as judged by phytohemagglutinin reactivity and delayed hypersensitivity to sheep cells, was unimpaired after s.c. cp ...	1976	1083289
effect of corynebacterium parvum on cellular and humoral antitumoral immune effector mechanisms.		1976	1083341
the effect of corynebacterium parvum on the humoral and cellular immune systems in patients with breast cancer.	corynebacterium parvum, a gram-positive anaerobic bacillus thought to be a strong immunological stimulant, has been shown to decrease tumour growth and prolong survival in patients with metastatic disease. study of the effect of a single injection of a strain of c. parvum (cn. 6134) in six patients with stage iv metastatic breast cancer is reported. results of laboratory tests to judge the physical and immunological effects of the drug infusion 24 hr post-treatment and weekly thereafter for 3 we ...	1976	1084821
abrogation of the anti-metastatic activity of c. parvum by antilymphocyte serum.		1976	1086096
mechanisms of antitumor action of corynebacterium parvum: replicating short-lived t cells as the mediators of potentiated tumor-specific immunity.		1976	1086362
bacillus calmette-guérin immunotherapy in combination with dtic (nsc-45388) for the treatment of malignant melanoma.	combination studies of immunotherapy and dtic chemotherapy for patients with malignant melanoma are described. at our institute the combination of bacillus calmette-guérin (bcg) with dtic, or dtic plus methyl-ccnu, has resulted in augmentation of remissions in areas regional to bcg immunization, prolongation of chemotherapy-induced remissions, and significant prolongation of survival compared to the use of dtic chemotherapy without immunotherapy. data from other centers have shown that augmentat ...	1976	769970
the role of macrophages in the adjuvant effect on antibody production of corynebacterium parvum.	spleen cells from mice pre-treated with c. parvum gave an enhanced in vitro antibody response to srbc, but not to dnp-pol. this enhancing activity was associated with the adherent, but not the non-adherent spleen cell population and was found to be radioresistant. it is concluded that macrophages are directly involved in the adjuvant effect of c. parvum and the possible mechanisms of action are discussed.	1976	770033
"xenogeneic resistance" to rat bone marrow transplantation. iii. maturation age, and abrogation with cyclophosphamide, corynebacterium parvum and fractionated irradiation.	lethally irradiated c57 bl/6 mice and (c57 x a) f1 hybrids fail to accept doses of rat bone marrow cells (5 x 10(6)) which give confluent splenic repopulation in "non-resistant" strains of mice. this phenomenon has been termed "xenogeneic resistance" (xr). xr in (c57 x a) f1 mice can be overridden by a very large inoculum of rat bone marrow (26 x 10(6) cells). xr is not manifest in mice of a resistant strain at ages of 18 days or younger, but is manifest at ages of 22 days and older. xr can be a ...	1976	773442
overview of tumor immunology in gynecologic oncology.	highlights of recent advances in the field of gynecologic tumor immunology are presented in an effort to demonstrate that at least some cancers of the female genitalia evoke an immune response that can be quantitated in the laboratory. the overview will discuss investigations into the various in vitro assays of both humoral and cell-mediated immunity. the concept of clinical testing of delayed hypersensitivity reactions as it relates to the clinical outcome of the patients with malignancy is pre ...	1976	776391
the effect of hydrocortisone on the immune response of mice treated with corynebacterium parvum.		1976	776469
enhancement of tissue invasion in murine aspergillosis by systemic administration of suspensions of killed corynebacterium parvum.	the effect of killed corynebacterium parvum vaccine on the course of murine aspergillosis is described. a grid-counting technique was employed to quantitate tissue invasion by aspergillus nidulans in the brain, heart, and kidneys (the target organs) of normal mice and of mice treated systemically with killed c. parvum vaccine. simultaneous treatment of mice with c. parvum and a. nidulans significantly increased the mortality rate, in contrast to treatment of mice with c. parvum prior to or follo ...	1976	779492
augmentation of specific macrophage-mediated cytotoxicity: correlations with agents which enhance antitumor resistance.		1976	782731
immunotherapy of cancer in man.		1976	786091
combined treatment of rodent fibrosarcoma by radiotherapy and immune adjuvant.		1976	786964
the immunobiology of colorectal cancer.		1976	793017
immunotherapy of cancer in man: current status and prospectus.		1976	793477
design of phase-i trials of immunopotentiators for cancer therapy: levamisole and corynebacterium parvum.		1976	793480
characteristics of bacteria isolated by the anaerobic roll-tube method from cheeses and ground beef.	in this study the methods of hungate were used to quantitate the anaerobic bacteria present in commercially available ground beef, cheddar cheese, and german hand cheese. of 235 anaerobic roll-tube isolates from ground beef and german hand cheese, all were facultative anaerobes. of 213 anaerobic roll-tube isolates from cheddar cheese, 91% were facultative anaerobes and 9% were obligate anaerobes. using results of biochemical tests, 14 or the 17 obligately anaerobic isolates from cheddar cheese w ...	1976	793523
relationship between intradermal tumor suppression and tumor immunity.	intradermal (id) injection of three tumor-immune stimulant mixtures (lstra-bcg, 13762a-bcg, cad2-corynebacterium parvum) was superior to the sc site for suppression of tumor growth: suppression of lstra-bcg mixtures was even less efficient after an ip or iv injectiouppression at all four sites. in the lstra-bcg model, the id site was not uniquely favorable for either the afferent or efferent limb of the immune response; the other sites produced equally effectiveimmunization or rejection of tumor ...	1976	794505
immunotherapy of gastrointestinal cancer: the potential.		1976	798647
immunocompetence, immunodeficiency and prognosis in cancer.	immunocompetence and prognosis are related in solid tumors, malignant lymphomas, and acute leukemia. among the parameters of immunocompetence vigorous delayed-type hypersensitivity responses to recall antigens or to primary immunization with keyhole limpet hemocyanin, vigorous in vitro lymphocyte blastogenic responses to mitogens such as pha, and relatively high b-lymphocyte levels, all correlate with a good prognosis. the spectrum of immune reactivity as measured by established delayed-type hyp ...	1976	800324
biological activities of propionibacterium acnes from the human oral cavity--dermal toxicity and res-stimulating activity.		1976	802175
hydrosoluble immunostimulants of bacterial and synthetic origins.	the role of whole mycobacteria, mycobacterial cell walls and waxes d as immunostimulants was well established many years ago. more recently three different research groups have shown that hydrosoluble components from mycobacterial and other bacterial origins were as active as waxes d or cell walls and were free of many side-effects. studies concerning the relationship between structure and activity were achieved which led to the description of a small biologically active fragment and to a first ...	1976	181265
[treatment of acne vulgaris in practice].	the aim of all acne therapy is sebostasis and treatment of corynebacterium acnes as well as secondary infected postular changes. after discussion of tretinoin (retinoic acid)-treatment it is reported about 35 cases of acne vulgaris which were treated with the combination of hexachlorophenspiritus 1%,silicatgel locally and tetracycline orally. the good results of this treatment are reported. side effects have not been observed.	1976	184016
c. parvum suppression of rat tumours in athymic nude mice.		1976	184813
immune response against hamster erythrocytes in the low-responder mouse strains. xi. strain difference in the effects of various microbial adjuvants.	enhancing and suppressing effects of microbial adjuvants were studied in female mice of the c3h/he, akr and sl strains. propionibacterium acnes, bordetella pertussis, bcg and yeast cell wall (ycw) were chosen as adjuvants. as antigens, we chose hamster erythrocytes (hrbc) which proved to be a weak antigen for mice. adjuvants were given on day --7, day 0 or day 3, and hrbc were injected on day 0. the results were as follows. 1) p. acnes facilitated igm and igg antibody production in akr mice and ...	1976	186656
immunochemotherapy with corynebacterium parvum in disseminated cancer.		1976	187100
clinical immunoadjuvant studies with tilorone, deaa fluorene (rmi 11,002da), and corynebacterium parvum and some observations on the role of host resistance and herpes-like lesions in tumor growth.		1976	187101
modulation of mouse anti-trinitrophenyl plaque-forming cell affinity by adjuvants or lectins.	the efffects of several kinds of adjuvants or lectins, such as corynebacterium parvum, dextran, poly au, poly ic, dibutyryl camp, concanavalin a (con a), phytohemagglutinin (pha) and pokeweed mitogen (pwm) on anti-trinitrophenyl (tnp) direct plaque-forming cells (pfc) in the spleen of mice and the affinity of antibodies produced by these pfc were examined. the numbers of anti-tnp pfc in the spleens of mice which had been injected with c. parvum 7 days in advance were greater than those in contro ...	1976	190432
[acne vulgaris: review of the pathogenecity and the therapeutic problem from bacteriological view point (author's transl)].		1976	138000
a microbial etiology of acne?	the view is advanced that sebum as originally produced must contain materials, other than lipids, which may serve as a selective substrate for growth of bacteria and yeasts. growth of large numbers of p. acnes and p. granulosum in some follicles is considered to place those follicles at risk of undergoing pathological changes. deleterious products of bacterial growth could be not only lipase and free fatty acids, but also other enzymes as well as bacterial antigens and unspecified toxins or irri ...	1976	138542
acne from an immunological perspective.	patients with acne vulgaris, particularly those with severe inflammatory forms of the disease, are known to have high titers of serum antibodies, and intensified immediate hypersensitivity reactions to p. acnes antigens. the significance of this fact has not been clarified, but it is possible that antigen-antibody reactions involving p. acnes in the perifollicular dermis could intensify the inflammatory response in certain forms of acne. further studies utilizing newer, more sophisticated techni ...	1976	138543
antibiotic resistant acne.	our approach to a patient who fails to respond to antibiotics is as follows: first, take a careful history. look for use of cosmetics and topical corticosteroids, anticonvulsive agents and systemic corticosteroids. inquire about marked increases in emotional or psychological stresses accompanied by noticeable seborrhea. probe the patient about habits of leaning on or squeezing acne areas, and most importantly, inquire how often and in what manner the patient washes. in the physical examination, ...	1976	138553
role of microorganisms in dandruff.	the role of microorganisms in dandruff was studied, by suppressing individually and then collectively the three major components of the scalp microflora. the effect on dandruff was assessed subjectively by clinical grading and objectively by the corneocyte count. no effect on dandruff was demonstrated when scalp organisms were suppressed. in the second group of experiments, dandruff was suppressed by selenium sulfide shampooling and the effect of continued suppression of pityrosporum with topica ...	1976	130835
[sebaceous filaments (author's transl)].	sebaceous filaments are cylindrical tubes of whitish-yellowish color, which can be expressed from areas of the face rich in sebaceous follicles by pinching the skin or by the cyanoacrylat-technique. sebaceous filaments are most commonly found in the centrofacial areas and the alae nasae in postpuberal individuals with large facial pores and seborrhea. sebaceous filaments are composed of a skeleton of 10-30 horny cell layers which enclose a mixture of bacteria, sebaceous lipid, corneocyte fragmen ...	1976	130839
acne vulgaris: current concepts in pathogenesis and treatment.		1976	131110
the microbiology of dandruff.		1976	131574
[the pathogenesis of acne vulgaris (author's transl)].	stickl's method of oral treatment of acne vulgaris with antigens has been carried out on 26 test persons. during the treatment the number of comedones increased significantly and the number of papules decreased significantly. biochemically, a significant increase of the free fatty acids and a significant decrease of the triglycerides could be demonstrated in the skin surface lipids, the total amount remaining unchanged. the following important conclusions for the pathogenesis of acne may be draw ...	1976	131909
[studies on ozone therapy of acne vulgaris].	ozone therapy using the vapozone 9, an instrument in normal commercial usage, has been carried out on the forehead of 16 male test persons on 7 consecutive days. before the treatment began and at the end of the treatment period the skin surface lipids on the unchanged skin (casual level) and two hours after defatting the skin (replacement sum) were taken by direct extraction and analysed by means of thin layer chromatography. the results of these investigations rule out a decrease in the free fa ...	1976	134522
topically applied antibiotics in acne vulgaris: clinical response and suppression of corynebacterium acnes in open comedones.	topical antibiotics were used on patients with acne vulgaris. corynebacterium acnes organisms from open comedones were quantitated during treatment, and the progress of the disease was evaluated. clindamycin lotion completely suppressed the growth of c acnes organisms, whereas erythromycin and tetracycline did not depress the c acnes counts. taken as a group, these antibiotics gave a substantial improvement of the disease on the treated side as compared with paired untreated sides of the face a ...	1976	134675
lipases: their questionable role in acne vulgaris.		1976	136423
[ultrastructure and microflora in follicles and comedones].	the resident flora of skin surface, sebaceous follicles, and acne comedones: pityrosporum, micrococci, and corynebacterium (propionibacterium) acnes is described. the nomenclature, topography, incidence, pathogenic role, and especially the ultrastructural morphology of these organisms are presented.	1976	136430
propionibacterium acnes: pathogen in central nervous system shunt infection. report of three cases including immune complex glomerulonephritis.	propionibacterium acnes is a pleomorphic gram-positive anaerobic rod usually isolated as a contaminant from skin. we report three cases of p. acnes infection of central nervous system shunts for hydrocephalus. the organism was seen repeatedly on gram stain in a specimen of shunt fluid in all three cases; initially, it was regarded as a contaminant. in addition, two of the patients had precipitins to extracts of their organism. serum from normal control subjects had no such precipitins. one of th ...	1976	137672
corynebacterium parvum toxicity.		1976	73819
symptoms from corynebacterium parvum.		1976	61475
[recent personal results in advanced bronchial cancer. palliative immuno-chemotherapy. 63 cases].		1976	64125
biological purpose of acne.	it is argued that the close endocrine control of human sebaceous glands and the likely effects of acne on selection indicate that both gland and disease have persisted because they are biologically useful. two possibilities are proposed: sebum may provide precursor substrates for metabolism and synthesis by the epidermis of compounds of both local and systemic importance; and the adjuvent properties of corynebacteria which colonise the active sebaceous glands of acne may facilitate certain gener ...	1976	58315
study of elastolytic activity propionibacterium acnes and staphylococcus epidermis in acne vulgaris and in normal skin.	histopathological sections of anetoderma-like scars from 10 patients with acne vulgaris showed a selective absence of elastic fibers around pilosebaceous follicles. this finding is similar to the histologic changes of "perifollicular elastolysis" reported by varadi. bacteria isolated by anaerobic and aerobic cultures of swabs of the skin surface and pus of these 10 patients, 12 others with active acne vulgaris and 8 normal subjects were studied with particular attention to staphylococcus epiderm ...	1976	60023
metronidazole and acne.	the strong activity of metroindazole against obligate anaerobes suggested that the organism proprionobacterium acnes and the disease acne vulgaris might respond to treatment with this drug. thirty-three clinical isolated of p. acnes were tested and found to be highly resistant to metronidazole. prospects for its successful use in acne are remote.	1976	60028
editorial: immunostimulation.		1976	60577
stimulation of the non-specific resistance by corynebacterium parvum and bacillus calmette guérin.	the effect of pretreatment of intravenously administered killed corynebacterium parvum (cp) and living bcg was studied in various model systems. both vaccines caused an increased resistance to listeria monocytogenes, indicating macrophage activation. only cp exerted a suppressive effect on t-cell-mediated immunological phenomena (skin allograft survival; antibody production to tetanus toxoid; expulsion of adult t. spiralis worms from intestine). results of experiments with congenitally athymic ( ...	1976	821172
the effects of activated macrophages on tumor target cells: escape from cytostasis.		1976	821620
mitogenic activity of the cell walls of mycobacteria, nocardia, corynebacteria and anaerobic coryneforms.	the mitogenic activity of the cell walls prepared from mycobacterium bovis bcg, nocardia rubra, corynebacterium diphtheriae pw8, and four species of propionibacterium, corynebacterium parvum atcc 11829, propionibacterium acnes c7, propionibacterium granulosum atcc 25564 and propionibacterium avidum atcc 25577, were investigated. these cell walls were active as mitogens on normal spleen cells, anti-o sera-treated spleen cells, macrophage-depleted spleen cells of c57bl/6j mice and cortisone-treate ...	1976	824484
interaction of tumor cells and activated macrophages in vitro: modulation by corynebacterium parvum and gold salt.		1976	825644
antitumor antibodies and immunoglobulin class and subclass levels in corynebacterium parvum-treated mice.	changes in immunoglobulin class and subclass levels and the development of antitumor antibodies were assessed in normal and tumor-bearing mice challenged with corynebacterium parvum. c. parvum administration resulted in a marked increase in certain immunoglobulin levels, especially ig g2b, and in the development of antibodies reacting with syngeneic and allogeneic tumor cells. the serologic changes induced by c. parvum were dependent on the dose and route of administration; preliminary studies s ...	1976	825650
specific and nonspecific antitumor immunity. iii. specific t lymphocyte-mediated cytolysis of p815 mastocytoma and sl2 lymphoma by draining lymph node cells from syngeneic tumor-bearing dba/2j mice.	tumor-specific cytolytic activity, as measured by the 51cr release assay, has been demonstrated in the draining lymph node cells from dba/2 mice bearing the syngeneic p815 mastocytoma or sl2 lymphoma. this lytic activity is mediated by cytolytic t lymphocytes (ctl), since cytotoxicity is eliminated by treatment of the effector cells with anti-thy 1.2 (theta) serum plus complement but is enhanced or unaffected by anti-thy 1.2 serum alone, antimouse immunoglobulin plus complement, normal or aggreg ...	1976	826167
studies on the enhancement by cyclophosphamide (nsc-26271) of artificial lung metastasis after labeled cell inoculation.	in a mouse model the retention of125i-5-iodo-2' -deoxyuridine-labeled tumor cells in the lung after iv injection was compared with the formation of tumor colonies in the lung 15 days after injection. the modification in lung retention after treatment with cyclophosphamide (cp), isophosphamide, corynebacterium parvum, and heparin paralleled the changes in lung-colony numbers by these treatments. since the modifications could be identified as early as 1 hour after iv administration of tumor cells, ...	1976	1064469
macrophage mediated tumor cell cytotoxicity.	the following evidence from our research has implicated the macrophage as an important effector cell in pyran and/or c. parvum induced host resistance to solid tumors: (1) increased infiltration of tumors with histiocytes following systemic treatment with pyran;17 (2) activated peritoneal macrophages with tumoricidal activity have been recovered from the peritoneal cavity of normal or tumor bearing mice treated with pyran or c. parvum;17 (3) activated peritoneal macrophages mixed with tumor cell ...	1976	1071961
taxonomical position of anaerobic diphtheroids from human oral cavity.		1976	1076074
mechanisms of macrophage activation by corynebacterium parvum. ii. in vivo experiments.		1975	1079165
daily intravenous infusions of corynebacterium parvum in twenty patients with disseminated cancer: a preliminary report of clinical and biologic findings.	twenty terminally ill patients with various disseminated tumors were treated with daily iv infusions of corynebacterium parvum given alone at doses of 4 mg/day, 5 days/week, for 4-16 weeks. in 8 patients (40%), the lesions partially regressed to less than 50% of their original size. another patient who did not improve with c. parvum therapy had a complete remission after the first course of chemotherapy. skin tests, total leukocyte counts, and t- and b-cell counts revealed variable and unpredict ...	1975	1080521
effect of local injection of corynebacterium parvum on the growth of a murine fibrosarcoma.	local injection (i.e. injection at the site of tumour inoculation) of strains of c. parvum which have a significant anti-tumour effect when given systemically (i.e. intravenously or, in the case of subcutaneous tumour transplant, intraperitoneally) strongly inhibits the growth of isogeneic transplants of a fibrosarcoma in intact cba mice but has little or no effect on subcutaneous transplants of the same tumour in t-cell deprived mice. the anti-tumour effect of local injection of c. parvum, unli ...	1975	1080671
active specific immunotherapy of mouse methylcholanthrene induced tumours with corynebacterium parvum and irradiated tumour cells.	the relative efficiency of active nonspecific or specific immunotherapy of developing methylcholanthrene induced fibrosarcomata with c. parvum was compared. for nonspecific immunotherapy, mice were challenged with tumour cells s.c. or i.v., and 2 days later injected i.v. with dilutions of c. parvum. the only significant effect was a retardation of s.c. tumour growth by the highest concentration of c. parvum (350 mug). however, active specific immunotherapy, using mixtures of c. parvum and irradi ...	1975	1082344
the effect of corynebacterium parvum therapy on immunoglobulin class and igg subclass levels in cancer patients.	detailed serological studies have been undertaken in a small group of cancer patients receiving nonspecific immunotherapy with corynebacterium parvum (c. parvum). these patients included 4 cases of recurrent malignant melanoma, 2 of stomach cancer and 2 of recurrent breast cancer. they all received an initial i.v. infusion of 20 mg of a formol killed suspension of c. parvum followed by 2 mg (i.m.) at weekly intervals for 10-11 weeks. this protocol consistently resulted in an increase in the circ ...	1975	61040
letter: corynebacterium parvum and anaesthetics.		1975	46085
editorial: immunological control of cancer.		1975	46965
letter: anaerobic corynebacteria and anaesthetics.		1975	47129
letter: corynebacterium parvum and anaesthetics.		1975	47551
letter: adjuvant contact suppression of experimental tumours.		1975	48032
letter: immunological control of cancer.		1975	48154
letter: toxicity of intravenous corynebacterium parvum.		1975	53574
letter: side-effects of intravenous corynebacterium parvum.		1975	53755
evidence for an allotypic marker on canine immunoglobulin.		1975	53927
[inhibition of antigenic competition by immunostimulants].	the diminution of immune response against srbc induced in mice, by a prior injection of hrbc was counteracted by addition of certain immunostimulants to srbc. the intensity of inhibition of antigenic competition was related to the quantity of immunostimulant added to srbc. some immunostimulants (b. abortus, lipopolysaccharide) were more active than others (c. parvum, poly i : c). to inhibit antigenic competition immunostimulant had to be injected after or in mixture with srbc never before.	1975	56240
analysis of anaerobic coryneform cell wall antigens by radioimmunoassay.		1975	56300
[effect of a polysan preparation for the treatment of acne on the growth of corynebacterium acnes and staphylococcus pyogenes aureus].		1975	125629
quantification of bacteria in isolated pilosebaceous follicles in normal skin.	a technique for quantitating bacteria in isolated pilosebaceous follicles is described. this involves microdissection of the follicles from biopsies of skin, using the method of chemical pretreatment of skin to facilitate the separation of the epidermis and epidermal appendages from the dermis. the aerobic cocci and anaerobic diphtheroids in pilosebaceous follicles in 66 biopsies of scalp and 48 biopsies of skin of the upper back were quantitated using this technique. on the back, aerobic staphy ...	1975	127814
ad hoc committee report: systemic antibiotics for treatment of acne vulgaris: efficacy and safety.		1975	128326
scientific approach to the treatment of acne vulgaris.		1975	129306
lipolytic activity of microorganisms in acne vulgaris.		1975	129776
ultrastructure of human sebaceous follicles and comedones following treatment with vitamin a acid.	ultrastructural findings in normal human sebaceous follicles, of comedones from acne patients, and from comedones during topical treatment with vitamin a acid (vaa) are described. in normal human sebaceous follicles, the two segments of the infundibulum-the acroinfundibulum and the infrainfundibulum-show differing ultramorphological patterns of keratinization. the incomplete horny layer of the infrainfundibulum is physiological and seems to be necessary for its normal function. on the other hand ...	1975	130781
[first clinical trials of treatment of primary liver cancer with immunostimulating agents administered by systemic or intratumoral route].		1975	170046
histological and combined chemoimmunostimulation therapy studies against a murine leukemia.	a graffi murine leukemia was utilized as a model system to investigate the effect of chemoimmunostimulation therapy. subcutaneous inoculation of approximately 1.0 times 10(6) tumor cells resulted in a rapidly growing tumor at the site of inoculation and subsequent development of splenomegaly and lymphoadenopathy. all animals succumbed to the leukemia within 24 to 30 days. treatment of diseased animals with two courses of cytoxan over a 2-week period resulted in a remission period of approximatel ...	1975	170212
suppression of cell-mediated tumour immunity by corynebacterium parvum.		1975	170531
effect of pretreatment with mycobacterium bovis (strain bcg) and immune syphilitic serum on rabbit resistance to treponema pallidum.	stimulation of the rabbit reticuloendothelial system with viable mycobacterium bovis (strain bcg), and other agents, had no effect on the development of syphilitic lesions after intradermal or intravenous inoculation with graded doses of treponema pallidum (virulent nichol's strain; mean infective doses less than 10). the simultaneous administration of immune syphilitic rabbit serum retarded the development of lesions, but this appeared to be due solely to the immune serum, suggesting no synergi ...	1975	172450
effect of corynebacterium acnes on interferon production in mouse peritoneal exudate cells.	corynebacterium acnes, an organism closely related to c. parvum, has been recognized to have a striking effect on the reticuloendothelial system, as well as on both humoral and cellular immunity. in mice previously exposed to c. acnes, serum interferon levels induced by injection of newcastle disease virus (ndv), chikungunya virus (cv), and polyinosinic-polycytidylic acid are suppressed. when peritoneal macrophages and lymphocytes from animals exposed to c. acnes were cultivated in vitro, their ...	1975	234914
[oral antigen treatment (oral vaccination) in acne diseases].		1975	236624
quantitative microbiology of the scalp in non-dandruff, dandruff, and seborrheic dermatitis.	the composition of the scalp microflora was assessed quantitatively in normal individuals and in patients with dandruff and seborrheic dermatitis, disorders characterized by increasing scaling. three organisms were constantly found: (1) pityrosporum, (2) aerobic cocci, and (3) corynebacterium acnes. pityrosporum (mainly pityrosporum ovale) made up 46% of the total microflora in normals, 74% in dandruff, and 83% in seborvheic dermatitis. the geometric mean number of organisms per cm-2 in non-dand ...	1975	237965
analysis of lipid composition of isolated human sebaceous gland homogenates after incubation with cutaneous bacteria. thin-layer chromatography.	the effects of specific species of skin bacteria on human sebaceous gland lipids in vitro were analyzed. isolated dissected sebaceous glands were pooled, homogenized, and sterilized, then incorporated into peptone-yeast extract medium and used as substrate for growth of propionibacterium acnes, p. granulosum, and staphylococcus epidermidis subgroup ii. the sebaceous lipids were analyzed by thin-layer chromatography before and after bacterial growth. the most striking effect of bacteria on sebace ...	1975	237966
the localization and distribution of gram-positive cocci in normal skin and in lesions of acne vulgaris.	the localization of gram-positive cocci in the normal skin and in the lesions of acne vulgaris was investigated using fluorescein-labeled antiserum raised to gram-positive, coagulase-negative cocci. the cocci were found in 10 of 19 specimens from normal facial skin and in 3 of 11 specimens from the normal skin of the rest of the body. the bacteria were found mostly in the openings of follicles, but in 6 of 10 facial skin specimens, they were also present deeply in the lumina of the dilated sebac ...	1975	239073
effect of corynebacterium parvum on the course of a listeria monocytogenes infection in normal and congenitally athymic (nude) mice.	spleen counts of listeria monocytogenes in normal mice challenged with various numbers of organisms were generally lower in mice injected 3 days previously with killed corynebacterium parvum. this increased resistance was unexpected since c. parvum generally inhibits t cell-mediated immunity, the functional immunity against listeria being t cell-dependent. the inhibitory effect on t cells seemed to be compensated by the stimulatory effect of c. parvum on macrophages. therefore, the experiments w ...	1975	808049
potentiation of the tumor-specific immune response by corynebacterium parvum.	strong, specific, cell-mediated antitumor immunity resulted from the sc injection into mice of corynebacterium parvum (cp) mixed with irradiated cells from mastocytoma p815 (ma), whereas injection of irradiated ma alone was without effect. maximum immunity was achieved with small doses of cp, and the injection sites of cp and irradiated ma did not need to be coincident but required common lymphoid drainage for immunity to result. the process was largely t-cell dependent but not dependent on the ...	1975	808637
[effect of immunostimulation by corynebacterium parvum on evolution and metastatic dissemination of lewis's tumor in mouse c57bl/6 mice].	treatment with corynebacterium parvum (c. parvum) produces a significant prolongation of survival time of lewis tumor bearing animals and reduces strikingly the incidence of pulmonary metastasis in syngeneic c57bl/6 mice. on the other hand, treatment with imuran, a known immunodepressive agent, reduces survival time and facilitates metastatic dissemination in the same model.	1975	809167
dichotomy between macrophage activation and degree of protection against listeria monocytogenes and toxoplasma gondii in mice stimulated with corynebacterium parvum.	in vivo and in vitro experiments were conducted to determine the effect of corynebacterium parvum treatment of mice on resistance of listeria monocytogenes and toxoplasma gondii. intravenous immunization with c. parvum conferred transient protection against intravenous challenge with listeria or an avirulent strain of toxoplasma but did not protect against a virulent strain of toxoplasma. compared with the level of protection conferred by c. parvum, a higher degree of resistance was noted when m ...	1975	811563
enhancement of resistance and suppression of immunization against experimental trypanosoma cruzi infection by corynebacterium parvum.	intravenous but not intraperitoneal injection of killed corynebacterium parvum either before or after intraperitoneal infection with the highly reticulotropic tulahuén strain of trypanosoma cruzi produced enhanced resistance against the infection in mice. in contrast, c. parvum had no effect when the infection was caused with the predominately myotropic y strain of t. cruzi. c. parvum given intravenously before immunization with killed culture forms of the y strain parasite consistently diminish ...	1975	811568
chemical and immunological studies on the cell walls of propionibacterium acnes strain c7 and corynebacterium parvum atcc 11829.	the chemical and immunological properties of the cell walls prepared from the cells of anaerobic coryneforms, propionibacterium acnes c7 and corynebacterium parvum atcc 11829, were partially investigated. the cell walls prepared from p. acnes c7 and c. parvum atcc 11829 were composed of fatty acids, polysaccharides consisting glucose, galactose and mannose and mucopeptides consisting mainly of alanine, glutamic acid, alpha, epsilon-diaminopimelic acid, glycine, muramic acid and glucosamine. as t ...	1975	811835
the effect of gold salts on tumour immunity and its stimulation by corynebacterium parvum.	the anti-inflammatory agent sodium aurothiomalate appears to act upon mononuclear phagocytes, inhibiting their lysosomal enzyme activity. evidence is presented that gold salts can increase the number of lung tumour nodules that develop following intravenous injection of tumour cells and pretreatment can enhance the take of a subcutaneous tumour inoculum. in contrast, they do not affect the later growth of tumour. gold salts can also suppress the action of systemically administered c. parvum in i ...	1975	813755