Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| pre-exposure rabies prophylaxis: efficacy of a new packaging and delivery system for intradermal administration of human diploid cell vaccine. | the efficacy of a newly designed syringe prepacked with human diploid cell vaccine in a sufficient quantity to deliver individual 0.1 ml doses intradermally was tested by injecting 40 veterinary students with a single dose on each of days 0, 7 and 28. a second group of 20 students received the ordinary series of three 1.0 ml intramuscular vaccine doses by needle and syringe. all participants in both groups developed neutralizing antibodies to rabies above the suggested minimum of 0.5 internation ... | 1984 | 6531959 |
| [sylvatic rabies: a pediatric problem?]. | rabies epizooty has been recently reported from several italian provinces: bolzano, udine, belluno, brescia, sondrio, varese, como and bergamo. the rate of spread of the infection through wild animals has been estimated in 50 km/year. we have reviewed the fundamental characters or rabies virus, the pathogenesis and clinical manifestations of disease. furthermore the fundamental guidelines of passive and active immunization will be stressed with spread emphasis to the pre-exposition active immuni ... | 1984 | 6533586 |
| antigenic characteristics of isolates associated with a new epizootic of raccoon rabies in the united states. | a panel of 23 monoclonal antibodies to the nucleocapsid protein of rabies virus was used to study the antigenic character of isolates of rabies virus from raccoons in the mid-atlantic region of the united states. comparison of the reaction pattern of these isolates with that of isolates of rabies virus collected from areas of major rabies outbreaks (skunk rabies in the midwestern united states, fox rabies in the northeastern united states, and raccoon rabies in the southeastern united states) su ... | 1984 | 6539356 |
| use of monoclonal antibodies to confirm vaccine-induced rabies in ten dogs, two cats, and one fox. | a panel of 8 monoclonal antibodies to rabies glycoprotein antigen was used to characterize the modified-live virus vaccines marketed in the united states during the last 10 years. thirteen of 14 rabies virus isolates from 11 dogs, 2 cats, and 1 fox suspected of developing vaccine-induced rabies were shown to have reactivity patterns that were identical to the vaccine administered. reactivity patterns for 20 rabies isolates from human beings, wild animals, or domestic animals with no history of r ... | 1984 | 6540768 |
| expression of rabies virus glycoprotein from a recombinant vaccinia virus. | rabies is one of the oldest diseases know to man, but its successful control has remained elusive. although effective vaccines of tissue culture origin against rabies do exist, such preparations are expensive. live vaccinia virus (vv) recombinants expressing influenza or hepatitis b antigens have recently been used to immunize against these diseases. we have now used this approach to produce a novel rabies vaccine. we first altered the rabies glycoprotein cdna by site-directed mutagenesis and re ... | 1984 | 6548799 |
| rabies antibody titres in vaccinated dogs. | in a field study, rabies virus neutralizing antibody titres were determined by the microtest modification of the rapid fluorescent focus inhibition test before and after primary vaccination in 30 puppies, and before and after booster vaccination in 59 previously vaccinated dogs. a commercial modified live virus vaccine was used. three weeks after primary vaccination the mean antibody titre was 102 +/- 90, but only 24 dogs presented for booster vaccination had detectable antibody levels (mean tit ... | 1984 | 17422460 |
| clinical trials in healthy volunteers with the new purified chick embryo cell rabies vaccine for man. | behringwerke has developed the new, safe and economical purified chick embryo cell (pcec) rabies vaccine. due to the purification by zonal centrifugation the compatibility of this vaccine is excellent. among 933 vaccinations in 219 healthy volunteers the only side-effect was mild pain at the injection-site in 17 vaccinations (1.7 per cent). the sero-conversion of pcec rabies vaccine was 100 per cent in the tested healthy volunteers. the kinetics of antibody induction after pcec rabies vaccine is ... | 1984 | 12055789 |
| rabies induced in a cat by high-egg-passage flury strain vaccine. | an adult male domestic short-hair cat developed posterior paralysis 22 days after being vaccinated for rabies with a high-egg-passage flury strain vaccine currently approved for use in cats. a diagnosis of rabies was confirmed by mouse inoculations, and viral typing using a panel of monoclonal antibodies demonstrated that it was vaccine induced. | 1983 | 12002593 |
| rabies in humans. | 1983 | 6554155 | |
| anti-idiotypic antibodies induce neutralizing antibodies to rabies virus glycoprotein. | rabbit anti-idiotypic antibodies (alpha id ab) were prepared against five murine monoclonal antibodies (mab) specific for the rabies virus glycoprotein. four of the mab were directed against three known, type-specific, neutralizing sites on the glycoprotein, and the other mab was directed against a topographically uncharacterized, nonneutralizing epitope. an absence of significant cross-reactivity among the alpha id ab for heterologous mab suggested that the alpha id ab were highly specific for ... | 1983 | 6605428 |
| persistence of rabies antibody in free-ranging raccoons. | the immune status of a wildlife population to rabies virus probably influences the occurrences of epizootics among that species in a given geographical area. this is not to say that enzootic transmission of the virus will not occur, but rather that attainment of epizootic levels may be hampered through herd immunity. after an epizootic of rabies in a raccoon population in the fall of 1970, a serologic surveillance program was initiated from november 1970 through august 1974. the surveillance pro ... | 1983 | 6619583 |
| mokola virus infection in cats and a dog in zimbabwe. | 1983 | 6623871 | |
| [specific and nonspecific humoral response to vaccination with the anti-rabies vaccination agents rabivac and vnukovo-32]. | 1983 | 6627311 | |
| rabies in oklahoma: report of a human case. | 1983 | 6631574 | |
| preliminary study on fixed rabies virus strain "roma". i: adaptation on bhk21/s13 cells. | in this study the attempts to adapt roma fixed rabies virus to bhk21/s13 cells and human diploid fibroblasts, for a better characterization of the virus, are reported. bhk21 cells were infected with the virus and maintained in culture for more than 100 passages. a persistently infected culture by rabies virus was obtained. attempts to propagate virus in human diploid fibroblasts were unsuccessful. | 1983 | 6633274 |
| [aspects of the immunogenic capacities of the fixed babeş rabies virus to vaccines prepared from nerve tissue of different categories of experimental animals]. | 1983 | 6635460 | |
| [antigenic activity and the reactogenicity of a concentrated, purified, uv-inactivated cultured rabies vaccine]. | the results of the study of concentrated, purified, uv-inactivated cell-culture rabies vaccine, obtained from strain vnukovo-22, passage 33-40, in the primary culture of syrian hamster kidney cells, demonstrated the pronounced antigenic potency of this vaccine: when introduced intramuscularly in 3-4 injections at certain intervals, it induced the production of virus-neutralizing antibodies in high titers. in tests on volunteers the vaccine proved to be nonreactogenic. | 1983 | 6637275 |
| a study of candidate rabies vaccines for a national reference preparation for the evaluation of antigenic potency. | an unconcentrated and a concentrated lot of rabies vaccine prepared in syrian hamster kidney cell culture from the vnukovo-32 strain have been examined for their suitability as national reference preparations for rabies vaccine. the antigenic potencies of the preparations were assessed by the nih test using both fixed and street strains of rabies virus and by the method of antibody induction. the candidate vaccines were calibrated in comparative assays with the who 3rd international reference pr ... | 1983 | 6643509 |
| rabies virus in the tonsils of a carrier dog. | a female dog, inoculated with a rabies isolate from the saliva of an apparently healthy ethiopian dog, developed rabies but later recovered without supportive treatment. rabies virus was isolated from the saliva collected 42, 169 and 305 days after recovery. sixteen months after it recovered, the dog suddenly died after giving birth to two stillborn puppies. at necropsy, viral antigen could be detected in the tonsils and the brain tissue, but viable virus was isolated from the palatine tonsils o ... | 1983 | 6651535 |
| antibody response to a single intradermal booster dose of rabies human diploid cell vaccine. | 1983 | 6654729 | |
| a continuous cell line, gk, derived from the kidney tissue of mongolian gerbil (meriones unguiculatus) and its virological application. | a fibroblast-like continuous cell line was established from the kidney tissue of the female mongolian gerbil (meriones unguiculatus) and designated as gk cell line. the cells were susceptible to the infection with several dna and rna animal viruses, particularly with four prototype strains of dengue viruses and the hep-flury strain of rabies virus. | 1983 | 6656002 |
| [therapeutic activity of the combined use of an interferon inducer and vaccine in experimental rabies]. | experiments in mice inoculated intramuscularly with a large dose of virulent street rabies virus demonstrated effectiveness of combined treatment with an interferon inducer (double-strand rna) and vaccine. the treatment was started 24 hours after inoculation. the degree of protection of the animals treated by the combined method depended on the site of ds-rna inoculation: intracerebral inoculation produced 58% protection (p less than 0.001), intravenous 35% (p less than 0,01), and intramuscular ... | 1983 | 6659475 |
| rabies neutralizing antibodies determination by the modified counterimmunoelectrophoresis test and the rapid fluorescent focus inhibition test. | the correlation between the modified counterimmunoelectrophoresis and the rapid fluorescent focus inhibition tests for detecting rabies virus antibodies in human sera was studied, using as reference the standard mouse neutralization test. statistical analyses showed good correlation among the three serological tests. there were no statistically significant differences in titers obtained by serum neutralization and rapid fluorescent focus inhibition tests and the estimated titers based on the res ... | 1983 | 6659741 |
| [preventive rabies immunization--is simplification in view?]. | 1983 | 6669819 | |
| study of the presence of rabies virus in indigenous bats. | one hundred and thirteen fruit eating and insectivorous bats were captured from different parts of bangladesh. antemortem and post mortem examinations of the bats for rabies were conducted. microscopic studies and biological tests were carried-out with bat's brain for the detection of rabies virus. the results were negative. it may therefore, be concluded that the insectivorous and fruit eating bats from different parts of bangladesh do not act as the reservoir for rabies virus. | 1983 | 6675666 |
| the use of various immunochemical, biochemical and biological methods for the analysis of rabies virus production in tissue cultures. | for the preparation of rabies vaccines, virus was grown in cultures of primary cells (bovine fetal kidney) or heteroploid cell lines (hak and vero). comparative analysis of concentrated and/or purified antigen has shown a good correlation between the protective capacity (as determined by the nih test for potency) on one hand, and hemagglutinating titer, optical absorbance at 280 nm and glycoprotein content (evaluated by the enzyme-immuno assay - eia) on the other. furthermore, the evaluation of ... | 1983 | 6677532 |
| protective antibodies after vaccination with human diploid cell rabies vaccine. | 1983 | 6681004 | |
| [modification of the incubation period of the fixed babeş strain in relation to the nature of the host cells. the effects on viral titer and on the immunogenic value of rabies vaccines]. | 1983 | 6336510 | |
| rhesus diploid rabies vaccine (adsorbed), a new rabies vaccine. ii. results of clinical studies simulating prophylactic therapy for rabies exposure. | rhesus diploid-cell-strain rabies vaccine (rdrv) (adsorbed) is a new rabies vaccine intended for use in man. sixty volunteers were given five doses of rdrv at 0, 3, 7, 14, and 28 days to simulate prophylactic treatment of persons exposed to a rabid animal. thirty-five volunteers were given commercial high-titer rabies immune globulin, 20 iu/kg, before the first dose of rdrv, and 25 were given rdrv without prior rabies immune globulin. antibody responses at 14, 28, and 42 days were comparable wit ... | 1983 | 6341639 |
| epidemiologic analysis of antigenic variations of street rabies virus: detection by monoclonal antibodies. | the nucleocapsid antigen of 204 strains of street rabies virus, which originated in europe, africa and asia, was analyzed by fluorescent antibody staining technique with a panel of 20 monoclonal antibodies specific for nucleocapsid of rabies and rabies-related viruses. a definite pattern of reactivity was observed with strains of the same geographic origin with the exception of strains originating from madagascar, thailand and iran which were more diversified. mice immunized with a vaccine prepa ... | 1983 | 6342369 |
| [identification of silvatic and arctic rabies strains using monoclonal antibodies]. | 1983 | 6346689 | |
| an in vivo and in vitro study of rabies virus infection of the rat superior cervical ganglia. | in the attempt to develop a homogeneous neuronal model to study rabies pathogenesis in vivo and in vitro, the superior cervical ganglia (scg) were chosen because of their unique features. in vivo infection of the scg was attempted by inoculation of fixed rabies virus into the anterior eye chamber. however, viral by this route as well as intracerebrally failed to infect this neuronal organ in adult rats whereas the infection was poorly efficient in 24 hours newborn rats. dissociated cell cultures ... | 1983 | 6347127 |
| rabies subunit vaccines. | 1983 | 6348210 | |
| immunofluorescent examination of the skin of rabies-infected animals as a means of early detection of rabies virus antigen. | correlations were made on immunofluorescence positivity to antirabies conjugate between cranium-derived nerve fibers in skin and traditional samplings of brain tissue from several species and illness categories of animals with naturally acquired rabies. the overall correlation of results from all categories was about 98% (n, 104) for those that were brain positive and 100% (n, 99) for those that were brain negative. some animals that ultimately developed rabies were found to have immunofluoresce ... | 1983 | 6355152 |
| experimental rabies in skunks: mechanisms of infection of the salivary glands. | striped skunks (mephitis mephitis) were inoculated into the right submandibular salivary gland with street rabies virus. they were killed at various times after inoculation and several tissues were examined by immunofluorescence and light microscopy. right and left superior cervical, nodose and trigeminal ganglia, medulla oblongata and at least three regions of right and left submandibular salivary glands were examined by the fluorescent antibody technique. intracerebral titrations of salivary g ... | 1983 | 6357414 |
| [comparison of 4 technics for serologic titration of antibodies against rabies virus in dogs]. | four different serological techniques were used for the determination of antibody levels against rabies virus in 55 vaccinated street dogs: mouse neutralization test (reference), rapid fluorescent focus inhibition test, plaque reduction test and immunoenzymatic test (protein a). the results obtained with each of the last three methods were compared with those obtained with the reference test: correlation coefficients were, respectively, 0.810, 0.812 and 0.682, each being significantly correlated ... | 1983 | 6358227 |
| rabies virus glycoprotein analogs: biosynthesis in escherichia coli. | the surface of rabies virus is composed of an approximately 60,000 dalton glycoprotein, in which most of the antigenic and immunogenic determinants of the virus reside. we have constructed plasmids for the direct expression in escherichia coli of the mature full length rabies glycoprotein gene and also for the expression of a glycoprotein gene which has been truncated to exclude the coding region for a hydrophobic, possibly transmembrane, domain of the protein. escherichia coli harboring the pla ... | 1983 | 6297004 |
| nucleotide sequence of a cdna clone encoding the entire glycoprotein from the new jersey serotype of vesicular stomatitis virus. | the nucleotide sequence of the mrna encoding the glycoprotein from the new jersey serotype of vesicular stomatitis virus (vsv) was determined from a cdna clone containing the entire coding region. the sequence of 12 5'-terminal noncoding nucleotides present in the mrna but not in the cdna clone was determined from a primer extended to the 5' terminus of the mrna. the mrna is 1,573 nucleotides long (excluding polyadenylic acid) and encodes a protein of 517 amino acids. only six nucleotides occur ... | 1983 | 6298453 |
| inhibition of rous sarcoma virus-induced transformation by preinfection with rhabdoviruses. | in vivo preinfection of chicks with rabies virus (rv) or vesicular stomatitis virus (vsv) ts 1026 inhibits tumour formation after superinfection with rous sarcoma virus (rsv). the degree of inhibition depends on the titre of the infecting viruses and the interval between rhabdovirus and rsv infection. in vitro, cells preinfected with vsv ts 1026 under non-permissive conditions and superinfected with rsv, are not transformed as judged by cell morphology, serum requirement for growth or the capaci ... | 1983 | 6300284 |
| immunoelectron microscopic localization of rabies virus antigen in central nervous system and peripheral tissue using low-temperature embedding and protein a-gold. | a protein a-gold technique was used in conjunction with low temperature embedding to visualize ultrastructurally mature virions and sites of viral replication in the brains of rabies virus-infected mice after peripheral inoculation of virus. the association of viral profiles and gold particles with synaptic membranes, microtubules and rough endoplasmic reticulum suggested a mechanism of rabies virus transport within the central nervous system. early interactions of inflammatory cells with the vi ... | 1983 | 6203925 |
| stability of human diploid-cell-strain rabies vaccine at high ambient temperatures. | a batch of lyophilised human diploid-cell-strain rabies vaccine was divided into three batches, which were exposed to different temperatures during their distribution to and storage at three centres in pakistan. vaccine potency after exposure to these temperatures was tested by measuring antibody response in those given the vaccine, and by three different laboratory tests. the results indicate that the vaccine retains its antigenicity for man and for laboratory tests despite continuous exposure ... | 1983 | 6132229 |
| rabies. | 1983 | 6132275 | |
| rabies vaccine prepared from the virus grown in japanese quail embryo cell cultures. | fixed rabies virus strain mniivp-74 was grown in japanese quail embryo cell cultures, concentrated by ultrafiltration and inactivated with beta-propiolactone. the resulting vaccine was markedly antigenic and immunogenic for laboratory animals. human volunteers injected with 2.0 ml vaccine on days 0, 3, 7, 14, 30 and 90 exhibited more intensive and longer antibody production than those injected daily for 14 days. | 1983 | 6133431 |
| stability of human diploid cell rabies vaccines. | 1983 | 6134059 | |
| structural proteins of fixed rabies virus in the suckling mouse brain. | structural proteins of fixed rabies virus grown in the suckling mouse brain were analysed by sds-polyacrylamide gel electrophoresis (page). the relative content of g protein to l, n and m1 proteins of brain-grown virus was much lower when compared with that of the virus grown in chick embryo fibroblasts. the results indicate that nucleocapsid complexes, consisting of l, n and m1 proteins were the predominant antigens accumulating in the brain. | 1983 | 6135337 |
| an economical regimen of human diploid cell strain anti-rabies vaccine for post-exposure prophylaxis. | vaccine regimens using 0.1 ml human diploid cell strain vaccine (hdcsv) given intradermally (id) in single and multiple sites, or with aluminum hydroxide adjuvant given subcutaneously (sc), were compared with the regimens of hdcsv and semple vaccine currently suggested by who. some groups were also given human rabies-immune globulin (hrig). neutralising antibody titres were monitored for 3 months. antibody was detected earliest in subjects given 0.1 ml hdcsv id at each of eight sites. the highes ... | 1983 | 6135830 |
| altered expression of rabies virus antigenic determinants associated with chronic infection and virulence. | 1983 | 6185633 | |
| characterization of an antigenic determinant of the glycoprotein that correlates with pathogenicity of rabies virus. | the pathogenicity of fixed rabies virus strains for adult mice depends on the presence of an antigenic determinant on the viral glycoprotein. two virus-neutralizing monoclonal antibodies have been used to identify this determinant. all pathogenic strains of fixed rabies virus bind to these antibodies and are neutralized by them, whereas nonpathogenic strains fail to react with these monoclonal antibodies and are not neutralized by them. antigenic variants of the rabies virus with altered glycopr ... | 1983 | 6185960 |
| [prophylactic and therapeutic activity of an interferon inducer in mice infected intracerebrally with rabies street virus]. | experiments in mice inoculated intracerebrally with street rabies virus demonstrated a protective effect of an interferon inducer (double-stranded rna of phage f2). a high degree of protection was observed after intracerebral inoculation of the inducer both 24 h before and 4 h after virus infection, with a considerable increase of the average life-span of the animals. intramuscular and intraperitoneal inoculation of the inducer proved ineffective. | 1983 | 6189300 |
| [effectiveness of dsrna as an interferon inducer in the intramuscular infection of mice with rabies street virus]. | a protective effect of double-stranded rna as interferon inducer was demonstrated in mice inoculated intramuscularly with street rabies virus. a significant degree of protection was observed when the inducer was inoculated intracerebrally and at the site of virus inoculation both 24 h before and 4 and 24 h after infection. inoculation of the inducer into the muscle opposite to the infected leg and subcutaneously into the back proved to be ineffective. it was established that rabies infection cou ... | 1983 | 6191440 |
| induction of antigen-specific antibody response in human peripheral blood lymphocytes in vitro by a dog kidney cell vaccine against rabies virus (dkcv). | in the present report an in vitro method for obtaining a secondary human antibody response to a dog kidney cell vaccine against rabies virus (dkcv) is described. cultures of peripheral blood mononuclear cells from normal rabies-immune and nonimmune donors were stimulated in vitro by dkcv. the production of virus-specific antibody in supernatant fluids was monitored by elisa. antibody was produced by lymphocytes from rabies-immune individuals, whereas those of nonimmune subjects consistently fail ... | 1983 | 6193180 |
| [intra-axonal circulation in peripheral nerves and its importance]. | 1983 | 6195741 | |
| intracytoplasmic neuronal inclusions in the hippocampus of non-rabid moose, alces alces (l.). | 1983 | 6196493 | |
| identification of rabies antigen in human and animal tissues. | 1983 | 6372590 | |
| genetic control of resistance to street rabies virus in mice. | resistance to intraperitoneally inoculated street rabies virus (srv) in mice was shown to be under genetic control. sjl/j, cba/j, dba/2j, and balb/can mice were resistant, whereas a/wysn/j and a.sw/snj mice were susceptible. in addition, female mice of the resistant balb/can and dba/2j strains were more resistant than their male counterparts. resistance was not controlled solely by the major histocompatibility locus because susceptible a.sw/snj and resistant sjl/j mice have the same h-2s haploty ... | 1983 | 6822785 |
| chemical and immunological analysis of the rabies soluble glycoprotein. | soluble glycoprotein (gs), purified from virion-depleted, rabies-infected tissue culture fluid, was chemically and immunologically analyzed. a comparison of this antigen with the virion-associated glycoprotein showed that gs lacks 58 amino acid residues from the carboxy terminus of the virion-associated glycoprotein. analysis with monoclonal antibodies revealed that all the epitopes of the viral glycoprotein are also present in the soluble glycoprotein. however, when tested for its ability to pr ... | 1983 | 6823748 |
| molecular basis of rabies virus virulence. ii. identification of a site on the cvs glycoprotein associated with virulence. | nine anti-g monoclonal antibodies were used to select mutants of the cvs strain of rabies virus resistant to neutralization. seven mutants were avirulent in adult mice and two others exhibited an attenuated pathogenicity. both categories were resistant to monoclonal antibodies 194-2 and 248-8. virulence appears to be associated with a particular configuration of a region of the glycoprotein which is located at the intersection of the epitopes recognized by these two monoclonal antibodies. our re ... | 1983 | 6827249 |
| studies on pathogenic, immunogenic, and protective efficiency of fox rabies virus before and after adaptation to cell culture: application to vaccination against rabies. | rabies virus from the submandibular salivary gland of a naturally infected fox was adapted to growth in bhk-21 cells. the pathogenicity of the original isolate and the cell culture adapted virus were compared by the intramuscular and oral routes in mice and foxes. animals surviving exposure were tested for serum rabies antibodies (immunogenic efficiency) and for their ability to survive a second challenge with rabies virus (protective efficiency). in mice, ratios between lethal and protective do ... | 1983 | 6831313 |
| the primary hamster kidney cell rabies vaccine: adaptation of viral strain, production of vaccine, and pre- and postexposure treatment. | the hamster kidney cell rabies vaccine was investigated as a substitute for classical nervous tissue rabies vaccine. the beijing strain of fixed rabies virus was adapted to primary hamster kidney cells (phkcs), and four types of rabies vaccine (plain, adjuvant, concentrated, and concentrated adjuvant vaccines) were developed for human use. the potencies of the vaccines met the requirements of the world health organization, and these vaccines elicited rather satisfactory antibody responses in vol ... | 1983 | 6833794 |
| antigenic sites on the cvs rabies virus glycoprotein: analysis with monoclonal antibodies. | antigenic variation in the glycoprotein of rabies (cvs-11) virus was studied. neutralization-resistant variant viruses were isolated in vitro at high frequency (10(-4) to 10(-5)) in the presence of anti-glycoprotein monoclonal antibody. analysis of these variants identified at least three functionally independent antigenic sites, based on the grouping of variants that were no longer neutralized by one or more of a panel of 24 monoclonal antibodies. competition radioimmunoassay suggested that one ... | 1983 | 6834008 |
| rapid test for detection of rabies antibodies in human serum. | a simple, sensitive, rapid method based on the principle of immunoadherence hemagglutination (iaha) has been devised for the detection of rabies antibody. in this test, fixation of complement to complexes of rabies antigen with specific antibodies is readily detected by agglutination of human erythrocytes bearing receptors for c3. sera from individuals undergoing preexposure rabies immunization were tested for rabies antibodies by the iaha method and by a virus neutralization test performed in t ... | 1983 | 6841582 |
| [effect of the interferon inducer rff2 on the course of an infection due to the rabies virus in mice]. | the data of the study on the influence of an interferon inducer, phage rff2 rna, on the course of infection with fixed rabies virus and on the formation of postvaccination immunity are presented. the inoculation of the inducer in a dose of 1 mg/kg was shown to produce interferon in the blood of white mice within 6 hours up to 320 units/ml which decreased by 24 hours to 20-40 units/ml. no protective effect, however, was observed upon intracerebral inoculation of white mice with fixed rabies virus ... | 1983 | 6845719 |
| prevalence of abortive canine rabies in chiang mai, thailand. | 1983 | 6854177 | |
| neurotropism of rabies virus. an in vitro study. | the relative susceptibility of neurons and glia, grown as monolayers in vitro, to rabies virus infection was explored. established cell lines of neuronal or glial phenotype and primary cultures of cells derived from mouse dorsal root ganglia (drc) or brain were used as homologues of the targets of rabies virus in the nervous system. fixed rabies virus (cvs) strain was used in most experiments; other fixed rabies strains (pv, hep, era) and a street rabies virus isolate were used in some. virus-ce ... | 1983 | 6864237 |
| a study of antibody levels in wild ruminants vaccinated against rabies. | the authors have vaccinated 22 fallow deer (dama dama) and 10 mouflons (ovis ammon musimon) against rabies with an inactivated vaccine: 4 fallow deer with 1 ml, 14 fallow deer and 10 mouflons with 2 ml, 4 animals were kept as controls (fallow deer). the antibody responses were checked by fluorescent foci inhibition carried out on blood samples collected during a two-year period. all the animals developed antibody titres and were still protected after 24 months. | 1983 | 6868344 |
| comparison of primary skunk brain and kidney and raccoon kidney cells with established cell lines for isolation and propagation of street rabies virus. | cell cultures prepared from skunk kidney, raccoon kidney, and skunk brain were compared with cer, murine neuroblastoma (c1300, clone na), baby hamster kidney (bhk-21, s-13), and dog kidney (mdck) cell lines for virus isolation and propagation of street and fixed rabies virus. the skunk brain cells were suitable for efficient replication of all the virus isolates. they were comparable to cer and murine neuroblastoma cells for virus isolation and propagation. none of the other cell cultures was sa ... | 1983 | 6885165 |
| [the effect of adjuvant substances on the antigenic activity of cellular antirabies vaccine in experiments on cattle]. | trials were conducted with young cattle to study the effect of adjuvants, applied subcutaneously and intramuscularly, upon the antigenic activity of live and inactivated cell rabies vaccine prepared from the vnukovo -32 strain at the level of the 107th series cell passage. cerebral vaccine of fermi type was also used in the trials for comparison. the antibodies were parallelly titrated by four methods, three of which were conducted in vitro. the levels of antirabies antibodies indicate a possibi ... | 1983 | 6426120 |
| the acetylcholine receptor as a cellular receptor for rabies virus. | characterization of specific host cell receptors for enveloped viruses is a difficult problem because many enveloped viruses bind to a variety of substrates which are not obviously related to tissue tropisms in the intact host. viruses with a limited cellular tropism in infected animals present useful models for studying the mechanisms by which virus attachment regulates the disease process. rabies virus is a rhabdovirus which exhibits a marked neuronotropism in infected animals. limited data su ... | 1983 | 6367238 |
| [use of monoclonal antibodies in virology]. | 1983 | 6322450 | |
| [rabies vaccine in czechoslovakia. ii. lyophilized rabies vaccine from brain tissue inactivated by uv irradiation]. | 1983 | 6218902 | |
| activity of human serum lipoproteins on the infectivity of rhabdoviruses. | the inhibiting activity of various human serum lipoprotein classes and their lipid components on the infectivity of rhabdoviruses has been studied. the research has been carried out according to different experimental procedures on both the vesicular stomatitis virus (indiana strain), and the fixed rabies virus (cvs strain). the results obtained have shown an inhibition of the infectivity of vsv and cvs, mainly linked to the very low and low density lipoprotein classes. it has also been demonstr ... | 1983 | 6306404 |
| [recent data on early interaction between rhabdovirus and the cell]. | 1982 | 6316285 | |
| inactivation of rabies virus in reagents used for the fluorescent rabies antibody test. | procedures for inactivating rabies virus in reagents used for the fluorescent rabies antibody test are described. mouse brain adsorbing suspensions containing greater than or equal to 10(9) 50% lethal doses of virus per ml were rendered noninfectious by treatment with 0.1% beta-propiolactone or by heating at 56 degrees for greater than or equal to 30 min. viable virus in tissue impression smears was inactivated by acetone fixation at 50 degrees c for greater than or equal to 30 min or by immersi ... | 1982 | 6749889 |
| small wild rodents rabies in czechoslovakia. | during a period of 1969-1979 a total of 3174 small wild rodents of the genus muridae and microtinae (predominantly microtus arvalis) were examined. the animals were trapped in five localities differing both in type of ecological conditions and epizootologic situation. fox-rabies occurred here either enzootically, or epizootologically, or had been completely absent for many years in one of the localities investigated. of the 71 isolated strains of rv 18 strains were isolated from brain, 25 from b ... | 1982 | 6749977 |
| oral immunization of foxes against rabies. laboratory and field studies. | a short description is given of the laboratory experience gained in oral immunization of foxes against rabies, and its application in a limited field trial in switzerland with an attempt to control two outbreaks of fox rabies. | 1982 | 6751678 |
| the dissemination of rabies virus into cranial nerves and other tissues of experimentally infected goats and dogs and naturally infected skunks. | immunofluorescence examination for rabies virus antigen performed on skin specimens acquired from experimentally inoculated rabid goats and some dogs, often show little or not fluorescence. this observation is contrary to results obtained by comparable examination of the skin of naturally infected animals and most experimentally infected dogs. in an effort to elucidate some factors associated with this experience, an experiment was performed to similarly examine the cranial nerves to see if the ... | 1982 | 6757169 |
| rabies-related viruses. | five viruses related to rabies occur in africa. two of these, obodhiang from sudan and kotonkan from nigeria, were found in insects and are only distantly related to rabies virus. the other three are antigenically more closely related to rabies. mokola virus was isolated from shrews in nigeria, lagos bat virus from fruit bats in nigeria, and duvenhage virus from brain of a man bitten by a bat in south africa. the public health significance of the rabies-related viruses was emphasized in zimbabwe ... | 1982 | 6758373 |
| [study of antigenic characteristics of strains of rabies virus in tunisia using monoclonal antibodies]. | 1982 | 6758715 | |
| [immunoenzymatic titration of glycoprotein, an in vitro technic for evaluation of the activity of antirabies vaccines]. | 1982 | 6759507 | |
| cytotoxicity reactions against target cells infected with rabies virus. | some aspects of the cytotoxicity reactions were studied in the rabies system. the antibody-dependent complement cytotoxicity (adc), the cellular cytotoxicity (cc), and the antibody-dependent cellular cytotoxicity (adcc) are shown, being the cytotoxic effect as evidenced by the 51cr released from the cells infected with the pasteur strain of rabies virus. some parameters such as time of cellular infection, the amount of infected cells, the concentration of complement, and the incubation time of t ... | 1982 | 6759519 |
| chiropteran rabies in minnesota: 1976-1980. | 1982 | 6759693 | |
| [indirect immunofluorescence microtest in the determination of antirabies antibodies]. | the a.a. describe an indirect fluorescent antibody microtest for the rapid detection and titration of antirabies antibodies. slides containing rabies antigen were prepared by planting 50% infected cells onto multiwelled teflon-coated slides. following fixation, slides were stored at -20 degrees c until used. the indirect fluorescent antibody microtest was compared to the rffit in titration of sera containing rabies antibodies. the test was found to be rapid, easy and reliable. | 1982 | 6765380 |
| amino acid sequence of the rabies virus glycoprotein deduced from its cloned gene. | double-stranded complementary dna was synthesized from rabies virus-specific glycoprotein mrna and inserted into the pst i site of pbr322. the glycoprotein inserted sequence contains approximately 1.75 kilobase pairs and lacks only approximately 35 nucleotides from the 5' terminus of the glycoprotein mrna. the nucleotide sequence indicates a polypeptide of 524 amino acids beginning with an initiation codon atg and ending with a termination of codon tga. the first 19 amino acids make up a signal ... | 1982 | 6897030 |
| [the early death phenomenon related to sensitization of mice with rabies antigen--qualitative study and kinetics]. | protection against challenge following rabies vaccination occurs early in the mouse. however, before this protection appears, vaccinated mice die earlier than control mice receiving a placebo. study of this 'early death' shows that this phenomenon occurs when challenge is made with the cvs fixed virus and a field isolate from the salivary glands of the fox; by different routes of inoculation and for various infectious doses, and finally, when this challenge is made before or after vaccination. t ... | 1982 | 6982148 |
| a single-radial-immunodiffusion technique for the assay of rabies glycoprotein antigen: application for potency tests of vaccines against rabies. | an assay for rabies glycoprotein antigen based on single-radial-immunodiffusion (srd) is described. rabies glycoprotein antigen at concentrations of 0.7 microgram/ml or greater (approx. 1 international unit, iu) produced well-defined srd reactions zones in immunoplates containing antibody to purified glycoprotein. plots of zone area against relative antigen concentration were linear. the method was found to be of suitable sensitivity fo in vitro potency assays of inactivated cell culture rabies ... | 1982 | 6802936 |
| thermostability of the rabies virion. optical density measurement technique applications. | the thermal degradation of rabies virus was determined by the variation in optical density at 260 nm during temperature rise. this variation, linked to denaturation of rna, was seen by an irreversible sigmoidal curve. analysis of the state of the virion by ultracentrifugation did not show any alteration in sedimentation. electron microscopy revealed a release of nucleic acid of the virions which were burst to a greater or lesser degree. the technical conditions of these measurements--speed of te ... | 1982 | 6813020 |
| [particularities of the morphogenesis of the rabies virus and of its morphology observed during routine culture controls through the electron microscope]. | whilst practising routine controls with an electron microscope on nil 2 cell cultures infected by the rabies virus, the occasion arose to reveal certain features of the morphogenesis of this virus and the particular action of glutaraldehyde which alters the aspect of the rabies virus. during the cultures, we witnessed, in succession, the production of morphologically normal virions, then progressively degraded virions whilst the cells recover and develop towards a chronic infection state. glutar ... | 1982 | 6813021 |
| is the acetylcholine receptor a rabies virus receptor? | rabies virus was found on mouse diaphragms and on cultured chick myotubes in a distribution coinciding with that of the acetylcholine receptor. treatment of the myotubes with alpha-bungarotoxin and d-tubocurarine before the addition of the virus reduced the number of myotubes that became infected with rabies virus. these findings together suggest that acetylcholine receptors may serve as receptors for rabies virus. the binding of virus to acetylcholine receptors, which are present in high densit ... | 1982 | 7053569 |
| dual role of the immune response in street rabiesvirus infection of mice. | the cellular and humoral immune responses of mice to footpad injection of salivary gland suspensions of street rabiesvirus were investigated. suppression of these responses with cyclophosphamide both increased the overall mortality rate from (50 to 100%) and delayed onset of disease signs and death for 1 to 2 weeks. despite the absence of disease signs in these immunosuppressed animals, virus was present in the central nervous system, as shown by fluorescent-antibody staining of corneal epitheli ... | 1982 | 7054123 |
| human diploid cell rabies vaccine. effectiveness of immunization with small intradermal or subcutaneous doses. | to determine antibody responses to small doses of human diploid cell rabies vaccine (hdcv), we determined rabies antibody titers in 124 volunteers who had been vaccinated with one of five primary preexposure regimens. in a sixth group of 47 persons previously vaccinated with duck embryo rabies vaccine (dev), we evaluated the booster responses after a 0.1-ml dose of intradermal (id) hdcv. persons in all five groups undergoing primary immunization received three doses of vaccine, one each on days ... | 1982 | 7057603 |
| rabies in ethiopia. | rabies is one of the most severe infectious diseases in ethiopia, with many cases of the disease diagnosed in various parts of the country. the dog is the species most responsible for human exposure, with over 98% of the human cases and vaccinations due to the bite of rabid or suspected rabid dogs. most of the treatments are due to stray dogs that bite, escape and are not available for observation. most of the people who die of rabies are under 40 years of age, and among adults, the majority of ... | 1982 | 7058785 |
| hemolysis and cell fusion by rhabdoviruses. | 1982 | 7060734 | |
| rabies treatment with vaccine of the fuenzalida-palacios type. | 1982 | 7074254 | |
| excretion of rabies virus in the saliva of dogs. | thirty-nine dogs were injected intramuscularly with either an ethiopian strain or a mexican strain of rabies virus. the excretion of rabies virus in the saliva was studied before and during illness. nine of 17 dogs that died after injection with the ethiopian strain had virus in the submaxillary glands. four of these dogs excreted virus in the saliva up to 13 days before signs of disease were observed. sixteen of 22 dogs that died after injection with the mexican strain had virus in the submaxil ... | 1982 | 7077094 |
| antibody responses to human diploid cell vaccine for rabies with and without human rabies immune globulin. | one hundred one volunteers with no exposure to rabies were given human diploid cell vaccine (hdcv) for rabies with or without 20 international units of human rabies immune globulin (hrig)/kg of body weight to evaluate schedules for therapy with hdcv and hrig after exposure. all of the volunteers who received three or more doses of hdcv alone or four or more doses of hdcv with hrig developed high titers of neutralizing antibodies by day 35, which persisted for at least 60 days. by day 7, of the 6 ... | 1982 | 7077095 |
| [specific activity of an uv-inactivated antirabies vaccine made from brain tissue administered in a shortened schedule]. | the results obtained in the study of the specific potency of rabies vaccine prepared from sheep brain tissue and inactivated by uv irradiation indicate that, even in the presence of the lowest immunogenicity index (0.5), 5-6 injections of the vaccine, made not daily, but at interval of 3 and 7 days, induced the production of antibodies in the titers not lower than those resulting from 14-20 daily injections of the same vaccine or fermi vaccine. the preparation inactivated by uv irradiation shoul ... | 1982 | 7080770 |
| specific activity of concentrated and purified cell culture rabies vaccine (cpcrv) from the strain vnukovo -32-107 in an experiment with therapeutical immunization of humans. | reactogenicity and specific activity of three series of concentrated and purified cell culture rabies vaccine (cpcrv) were studied in an experiment of therapeutical immunization of 300 human subjects bitten by domestic animals, category "c". cpcrv was well tolerated; when administered intramuscularly, it did not provoke local reactions, while general reactions, such as temporary headaches and indisposition, were observed in 4% of cases. intradermal revaccination with cpcrv was followed by local ... | 1982 | 7086124 |
| vaccine-induced rabies in four cats. | vaccine-induced rabies in 4 cats was characterized by rigid posterior paralysis. in 3 cats, paralysis began in 1 hindlimb and rapidly spread to the other hindlimb. later, forelimb and cranial nerve deficits were noticed. onset of clinical signs was 13 to 17 days after im vaccination with an era-strain modified live-virus rabies vaccine approved for use in cats. each cat eventually was euthanatized. in each case, brain tissue was found to contain rabies virus on fluorescent antibody and mouse ino ... | 1982 | 7096177 |
| evaluation of a human diploid cell strain rabies vaccine: final report of a three year study of pre-exposure immunization. | the antibody responses of 194 volunteers were studied for up to 3 years after primary immunization with one, two or three doses of human diploid cell rabies vaccine, administered either in 0.1 ml volumes intradermally (i.d.) or as 1.0 ml intramuscularly (i.m.). sero-conversion occurred in 95% of subjects after the first injection and in 100% after the second. the highest titres and most durable antibody responses were induced by three injections of vaccine. booster doses were administered either ... | 1982 | 7096998 |
| isolation and study of temperature-sensitive mutants of rabies virus. | one-hundred and seventeen temperature-sensitive (ts) mutants have been isolated from the challenge virus strain (cvs) of rabies virus (rv). the criterion used for this selection was the absence of plaque-forming units on cer cells under agarose medium at the non-permissive temperature (npt) of 38.5 degrees c. of these mutants, 102 were induced by 5-fluorouracil. this compound was much more effective as a mutagen than either nitrous acid or the alkylating agents ethyl methanesulphonate and methyl ... | 1982 | 7097248 |