Publications

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[susceptibility of some laboratory and wild mammals to infection by uzbek strains of leishmania tropica major isolated from gerbils (rhombomys opimus licht.)]. 19664238258
[a comparative study of the virulence of leishmania tropica major strains]. 19655869240
[changes in virulence of strains of leishmania tropica major]. 19655876190
[some pathomorphological changes in experimental leishmaniasis in cricetulus auratus in infection with the central asian strains of leishmania canis and leishmania tropica major]. 196314159547
[on the dimensions of the leishmanial forms of leishmania tropica major and leishmania tropica minor]. 196214031792
zoonotic disease in a peripheral population: persistence and transmission of leishmania major in a putative sink-source system in the negev highlands, israel.populations at the edge of their geographic distributions are referred to as peripheral populations. very little attention has been given to this topic in the context of persistence of infectious disease in natural populations. in this study, we examined this question using zoonotic cutaneous leishmaniasis (zcl) caused by leishmania major in the negev desert of israel as a model system. here, we suggest that the regional persistence of phlebotomus papatasi populations and l. major transmission i ...025072990
distribution, fauna and seasonal variation of sandflies, simultaneous detection of nuclear internal transcribed spacer ribosomal dna gene of leishmania major in rhombomys opimus and phlebotomus papatasi, in natanz district in central part of iran.zoonotic cutaneous leishmaniasis (zcl) due to leishmania major is increasing in many parts of iran. this disease originally is a disease found in gerbils. leishmania parasites are transmitted by sandflies that live and breed in gerbil burrows. nested pcr amplified leishmania its1-5.8s rrna gene in both main reservoir host "rhombomys opimus" and in the "phlebotomus papatasi" main vector of zcl, in iran. population differentiation and seasonal variation of sandflies were analyzed at a microgeograp ...022801285
the first detection of leishmania major in naturally infected sergentomyia minuta in portugal.phlebotomine sandflies of the genus sergentomyia are widely distributed throughout the old world. it has been suggested that sergentomyia spp are involved in the transmission of leishmania in india and africa, whereas phlebotomus spp are thought to be the sole vectors of leishmania in the old world. in this study, leishmania major dna was detected in one sergentomyia minuta specimen that was collected in the southern region of portugal. this study challenges the dogma that leishmania is exclusiv ...023828004
natural infection of north african gundi (ctenodactylus gundi) by leishmania tropica in the focus of cutaneous leishmaniasis, southeast tunisia.north african gundis (ctenodactylus gundi) were trapped in the leishmania (l.) tropica focus of cutaneous leishmaniasis, situated in southeast tunisia and evaluated for leishmania infection by real-time kinetoplast dna polymerase chain reaction (pcr). species identification was performed by internal transcribed spacer one (its1)-pcr-restriction fragment length polymorphism (rflp) and high-resolution melting (hrm) analysis of the 7sl rna gene. real-time pcr on blood was positive in 6 of 13 (46.2% ...022665601
resurgence of cutaneous leishmaniasis in israel, 2001-2012.cutaneous leishmaniasis has long been endemic in israel. after a 15-year period of moderate illness rates, reported incidence increased from 0.4 cases per 100,000 population in 2001 to 4.4 cases per 100,000 population in 2012, and the disease emerged in areas where its presence had previously been minimal. we analyzed all cases reported to the national surveillance system and found that outbreak patterns revealed an expansion of leishmania major infections over large areas in the southern part o ...025271882
the flagellar protein flag1/smp1 is a candidate for leishmania-sand fly interaction.leishmaniasis is a serious problem that affects mostly poor countries. various species of leishmania are the agents of the disease, which take different clinical manifestations. the parasite is transmitted by sandflies, predominantly from the phlebotomus genus in the old world and lutzomyia in the new world. during development in the gut, leishmania must survive various challenges, which include avoiding being expelled with blood remnants after digestion. it is believed that attachment to the gu ...025793476
identification of leishmania species by kinetoplast dna-polymerase chain reaction for the first time in khaf district, khorasan-e-razavi province, iran.cutaneous leishmaniasis (cl) is an endemic parasitic skin disease in many parts of iran including khorasan province. both clinical forms of the disease, anthroponotic cutaneous leishmaniasis (acl) and zoonotic cutaneous leishmaniasis (zcl) are present in this province. however, leishmaniasis molecular map is determined in four cities of khorasan, but several foci still are remained unknown.025709953
kazal-type serine proteinase inhibitors in the midgut of phlebotomus papatasi.sandflies (diptera: psychodidae) are important disease vectors of parasites of the genus leishmania, as well as bacteria and viruses. following studies of the midgut transcriptome of phlebotomus papatasi, the principal vector of leishmania major, two non-classical kazal-type serine proteinase inhibitors were identified (ppkzl1 and ppkzl2). analyses of expression profiles indicated that ppkzl1 and ppkzl2 transcripts are both regulated by blood-feeding in the midgut of p. papatasi and are also exp ...024037187
nested polymerase chain reaction and sequence- based detection of leishmania infection of sand flies in recently emerged endemic focus of zoonotic cutaneous leishmaniasis, southern iran.geographical distribution of zoonotic cutaneous leishmaniasis (zcl) has continuously been extended in recent years in iran. the beiza district is one of the newly-emerged endemic foci of zcl in southern iran. the main aim of the present study was to detect the vector(s) of zcl in this area.024031105
anti-toll-like receptor 2 and 4 antibodies suppress inflammatory response in mice.toll-like receptors (tlrs) 2 and 4 recognize different endogenous and exogenous agonists and play a distinct role in infection and inflammation. however, their ultimate effect in a given infectious and inflammatory disease is less understood. we produced polyclonal anti-murine tlr2 and tlr4 antibodies and investigated their effect on cutaneous leishmaniasis and inflammatory arthritis. administration of these antibodies to susceptible balb/c mice, infected in the footpad with leishmania major, re ...024801735
epidemiology, pathology and treatment of cutaneous leishmaniasis in taif region of saudi arabia.cutaneous leishmaniasis is an annoying and disfiguring disease affecting around 1,500,000 individuals globally. there are endemic pockets of this disease in taif region. in some patients, lesion often weeps and leads to scar formation. the study was conducted to see the efficacy of fluconazole and itraconazole in the patients of cutaneous leishmaniasis and the effect of these drugs on liver enzymes and kidney markers.025678921
antileishmanial activity of prenylated coumarins isolated from ferulago angulata and prangos asperula.leishmaniasis has a wide spectrum of signs and symptoms due to infection to numbers of leishmania species and makes enormous mortality and morbidity. there are clues of antileishmanial effects of prenylated coumarins. apiaceae family is one of the most important sources of coumarins. air-dried aerial parts of ferulago angulata and fruits of prangos asperula were extracted with n-hexane, using a soxhlet apparatus. the solvents were evaporated under reduced pressure. column chromatography and crys ...027651813
frequency of cutaneous leishmaniasis and species identification in suspected individuals from golestan province, northern iran in 2014.leishmaniasis is a zoonotic disease caused by species of protozoa of the genus leishmania. in recent years, incidence of cutaneous leishmaniasis has increasing trend in golestan province, north of iran. the aim of the present study was to identify the frequency of cutaneous leishmaniasis using pcr-rflp in patients referred to kalaleh health center, during 2013-14.027957442
identification of the causative agent of cutaneous leishmaniasis in chichaoua province, morocco.cutaneous leishmaniasis (cl) in morocco is caused by three species, leishmania major, l. tropica and l. infantum. cl has been known in chichaoua province since 2000. using dna extracted from microscopic slides and parasite cultures, collected in the years 2006 and 2009, we identified for the first time l. tropica as the causative agent of cl in this region. species identification was achieved by performing the its1-pcr-rflp approach. by using this method it was possible to identify parasites in ...022314244
a comprehensive review of cutaneous leishmaniasis in kerman province, southeastern iran-narrative review article.cutaneous leishmaniasis (cl) remains a serious public health concern in kerman province, eastern iran. this study was aimed to conduct a comprehensive review and highlights various aspects of cl in the province of kerman.025905072
multiple-stage linear ion-trap with high resolution mass spectrometry towards complete structural characterization of phosphatidylethanolamines containing cyclopropane fatty acyl chain in leishmania infantum.the structures of phosphatidylethanolamine (pe) in leishmania infantum are unique in that they consist of a rare cyclopropane fatty acid (cfa) containing pe subfamily, including cfa-containing plasmalogen pe species. in this contribution, we applied multiple-stage linear ion-trap combined with high-resolution mass spectrometry to define the structures of pes that were desorbed as [m - h](-) and [m - h + 2li](+) ions by esi, respectively. the structural information arising from ms(n) on both the ...024619546
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