Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| effects of corynebacterium parvum on granulocyte/macrophage production and toxicity of chemotherapy. | 1977 | 305373 | |
| a role for t lymphocytes in the antitumour action of systemic c. parvum. | the frequency of tumours arising from s.c. injection of a syngeneic chemically-induced fibrosarcoma (fsa) was not influenced by systemic administration of c. parvum (day + 3) except when doses less than the td50 were injected. then the number of takes was increased. the tumour normally grows progressively however regression was frequent in intact mice treated with c. parvum. tumour regression did not occur in t cell-depleted mice treated in the same way. splenic t cell-enriched populations of ce ... | 1977 | 305374 |
| possible mechanisms in the anti-tumour activity of c. parvum. | normal murine peritoneal macrophages exhibited anti-tumour cytotoxicity following simultaneous incubation with c. parvum and lymphoid cells from c. parvum-treated mice. both t- and b-lymphocytes appear to be involved in this macrophage activation which is mediated by a soluble factor(s) released by immune lymphoid cells in response to the specific immunising strain of c. parvum. cells capable of macrophage activation do not appear until 6 days following systemic c. parvum administration despite ... | 1977 | 305375 |
| a comparison of pyrogenicity and related properties seen in a suspension of corynebacterium parvum and a gramnegative organism. | when the pyrogenic properties of c. parvum and a gramnegative organism, s. typhimurium, were compared it was found that the onset of the pyrogenic response to c. parvum was delayed relative to that of s. typhimurium and that secondary responses rarely occurred. in further experiments the interaction of c. parvum and s. typhimurium was studied. although synergism was not demonstrated, the kinetics of the response to mixtures of the two vaccines was anomalous while pre-treatment of rabbits with c. ... | 1977 | 320069 |
| tumor immunology and immunotherapy. | tumor cells contain a variety of antigens, including tumor associated antigens. the tumor associated antigens can be clinically useful as markers for detection of cancer and some may also mediate host resistance against tumor growth. much emphasis has been placed on the detection of circulating tumor associated markers, with radioimmunoassays for carcinoembryonic antigen (cea) being extensively utilized. at present, cea does not appear to be promising for initial detection of cancer, but may fin ... | 1977 | 321899 |
| immunotherapy of cancer. | clinical studies have indicated a close relationship between immunological competency and the growth of human cancer. studies in animal systems have indicated that immunological mechanisms are important in host-tumor existence. a number of agents are in the process of being evaluated for their immunotherapeutic potential in patients with cancer. these include levamisole, bacille calmette guérin (bcg) and corynebacterium parvum. while the precise role of these agents in the treatment of human mal ... | 1977 | 322390 |
| [treatment of solid tumours by intratumoral injection of immunostimulants]. | intra-lesional injections of immunostimulants--bcg or corynebacterium parpum--induced a local cure of the mcfifj2(s) tumour and a remote therapeutic effect. when applied to rats multigrafted with the mcfifi2(s) tumour, local and distant cures were obtained in some situations. this indicates the likely intervention of a specific immune mechanism. quantilating the pulmonary metastasis in combination with local treatment of lewis mouse tumours showed that bcg plus c. parvum injected into the tumour ... | 1977 | 322574 |
| functional heterogeneity in macrophages activated by corynebacterium parvum: characterization of subpopulations with different activities in promoting immune responses and suppressing tumor cell growth. | peritoneal cells (pec) from mice injected i.p. with heat-killed corynebacterium parvum (cp) showed enhanced immunostimulatory (accessor or a cell) activity as measured by their ability to restore the immune responsiveness of nonadherent spleen cells to sheep erythrocytes (srbc) and polymeric flagellin (pol) of salmonella adelaide in vitro. this was true whether the pec and nonadherent spleen cells were in direct contact or separated by a cell-impermeable membrane which allowed the free passage o ... | 1977 | 323353 |
| immunological properties of propionibacterium acnes. i. potentiation and suppression on antibody response to sheep and hamster erythrocytes in mice. | adjuvant activity of phenol-treated cells of propionibacterium acnes c-7 in antibody response was investigated in icr mice. simultaneous administration (day 0) of p. acnes (i.p.) and sheep red blood cells (srbc) (i.v.) enhanced the formation of direct plaque-forming cells (pfc) on days 2, and the formation of indirect pfc response on day 7 and thereafter. conversely, pretreatment from 11 to 14 days before antigen injection suppressed markedly the antibody response. the potentiation and the suppr ... | 1977 | 323645 |
| effects of bcg and corynebacterium parvum on the haemopoietic precursor cells in continuously irradiated mice: possible mechanisms of action in immunotherapy. | 1977 | 324769 | |
| effect of anti-thymocyte serum, anti-macrophage serum, and latex particles on the therapeutic efficacy of bcg or corynebacterium liquefaciens (propionibacterium acnes c7) in syngeneic mice. | in a syngeneic mouse-tumor system, anti-thymocyte serum, anti-macrophage serum, and latex particles were used for a comparative study of the immunotherapeutic efficacy of intradermal inoculation of tumor cell-bcg and tumor cell-corynebacterium liquefaciens (=propionibacterium acnes c7) vaccines. anti-thymocyte serum treatment nullified suppression of tumor mediated by bcg (living and nonliving) and living c. liquefaciens. however, the effect of nonliving c. liquefaciens was not affected so much ... | 1977 | 324858 |
| [growth of non-sporing anaerobes in an oxygen-free blood culture system (author's transl)]. | the efficacy of the commercially available vacutainer blood culture system to support the growth of non-sporing anaerobes was compared with two laboratory-prepared blood culture media (supplemented thioglycollate medium and brain heart infusion). the media were inoculated with 10, 100 and 1000 organisms of the species tested, and the number of colony-forming units was determined at intervals of 8-10 hrs. analogous experiments were performed with batches of the media to which 10% vol/vol of human ... | 1977 | 325956 |
| immunologic aspects of cancer chemotherapy. | 1977 | 326163 | |
| adjuvant activity of propionibacterium acnes isolated from the human oral cavity. | 1977 | 326235 | |
| resistance to parental, allogeneic and xenogeneic hemopoietic grafts in irradiated mice. | 1977 | 326573 | |
| superoxide dismutase in anaerobic bacteria of clinical significance. | twenty-two anaerobic bacteria isolated from infected sites and normal fecal flora were assayed for superoxide dismutase (sod). the organisms were also classified according to their oxygen tolerance into aerotolerant, intermediate, and extremely oxygen-sensitive groups. there was a correlation between the enzyme level and the oxygen tolerance, in that the aerotolerant and intermediate organisms had sod, whereas the extremely oxygen-sensitive isolates had low or undetectable enzyme. among the oxyg ... | 1977 | 326669 |
| complement activation by the alternative pathway and macrophage enzyme secretion in the pathogenesis of chronic inflammation. | a number of stimuli known to induce acid hydrolase secretion from cultured macrophages were examined for their ability to activate c3 via the alternative pathway of the complement system. loss of haemolytically active c3 was checked in normal and c4-deficient guinea-pig serum. for comparison the interactions of cultured macrophages with other agents well known as potent activators of the alternative pathway of the complement system have been investigated. as judged by their activity in these ass ... | 1977 | 328387 |
| adjuvant protection against bacterial infection in granulocytopenic mice. | the hypothesis that the induction of nonspecific resistance to infection by immunostimulation prior to drug-induced granulocytopenia would afford increased protection to subsequent bacterial challenge was tested in a murine model of infection with pseudomonas aeruginosa or staphylococcus aureus in mice rendered granulocytopenic with cyclophosphamide. prior intraperitoneal immunostimulation of mice with complete freund's adjuvant (cfa) or mycobacterium bovis (bacille calmette-guèrin; bcg) increas ... | 1977 | 328788 |
| mechanisms of action of immunopotentiating agents in cancer therapy. | 1977 | 329658 | |
| penetration of cells into millipore diffusion chambers. | 1977 | 330180 | |
| plasmodium yoelii and plasmodium vinckei: the effects of nonspecific immunostimulation on murine malaria. | 1977 | 330190 | |
| in vivo transfer of antitumor activity by peritoneal exudate cells from mice treated with corynebacterium parvum: reduced effect in irradiated recipients. | 1977 | 330869 | |
| management of metastatic breast cancer. | 1977 | 330978 | |
| canine migration inhibitory factor: effect of corynebacterium parvum administration. | peripheral blood lymphocytes from dogs sensitized to streptolysin o (slo) were assayed for migration inhibitory factor (mif) production by the indirect mif test, using guinea pig peritoneal exudate cells as the source of macrophages. a specific direct correlation was established between the degree of inhibition of migration and the concentration of slo-stimulated supernatants from lymphocyte cultures (slo-s) of untreated normal dogs. undiluted slo-s inhibited migration by 66.8%, whereas a diluti ... | 1977 | 332636 |
| corynebacterium parvum as the priming agent in the production of tumor necrosis factor in the mouse. | 1977 | 333124 | |
| [porphyrinsynthesis by propionibacterium acnes (author's transl)]. | strains of p.a. were isolated from seborrheic filaments from 11 persons and investigated according to their production of porphyrins. after growing the organisms during a 5 resp. 10 days cultivation period on solid as well as in liquid culture medium the quantity and quality of the bacterial porphyrins were determined. there existed intense variations in quantity not only when the special strains were compared with each other but also when the same strains were treated with different preparation ... | 1977 | 334087 |
| mechanism of corynebacterium parvum anti-tumour activity. ii. protective effect in t-cell-deprived mice. | the natural resistance to syngeneic mammary carcinoma was reduced by thymectomy alone in adult c3h mice or in mice thymectomized, lethally irradiated and restored with bone-marrow cells (tx rb). the protective effect of c. parvum was not modified by adult thymectomy but it was reduced in tx rb mice. the injection of thymic cells to tx rb mice or the elimination of t cell precursors in bone-marrow cells injected in tx rb mice did not increase the protective effect of c. parvum. these results were ... | 1977 | 334678 |
| immunotherapy in the treatment of cancer. | this article is a review of immunotherapy in the treatment of cancer incorporating the history of immunotherapy in the nineteenth and twentieth centuries, assessment of the techniques currently in use and of possible future developments. although immunotherapy is not established as a therapeutic technique, evidence suggests that the immune response does influence the development of neoplastic cells. a better understanding of the immune response and its control may lead to the production of effic ... | 1977 | 337486 |
| the reversal of established enhancement in rat cardiac allografts. | established enhancement in rat cardiac allografts was challenged in a variety of ways in an attempt to provoke rejection. incompatible skin grafts, injections of sensitised lymphocytes, and the administration of the macrophage-stimulating agent corynebacterium parvum proved ineffective. however, levamisole, which stimulates both macrophages and sensitised lymphocytes, caused rejection in four of a group of six as rats bearing enhanced (august x as)f1 hybrid heart allografts. a combination of c. ... | 1977 | 339437 |
| corynebacterium parvum as an immunotherapeutic agent in an ovarian cancer model. | corynebacterium parvum, an anaerobic diptheroid, has been demonstrated to be therapeutic in several tumor models by stimulating immunologic defenses. formalin-killed c. parvum was investigated in the present study as an immunotherapeutic agent in the treatment of murine ovarian cancer, a model that closely simulates the activity of clinical disease. c. parvum successfully prolonged survival in murine ovarian cancer and its effectiveness improved with increasing dosage. the efficacy of c. parvum ... | 1977 | 560124 |
| [anerobic corynebacteria propionibacterium as immunostimulators and antioncogenic factors]. | 1977 | 564299 | |
| [antitumor effect of corynebacterium parvum]. | the protective effect produced by pre-treatment with c. parvum is studied in two syngeneic tumours: mammary carcinoma in c3h mice and lymphosarcoma in xvii mice. the best anti-tumour effect is obtained when both c. parvum and tumour cells are injected by the same route, which, however varies for the two tumours. the study of the recovery of c. parvum protective effect after its suppression by a sub-letal dose of x-irradiation shows that, in the c3h mice, it is parallel to the restoration of the ... | 1977 | 576780 |
| use of litmus milk agar for presumptive identification of cutaneous propionibacteria. | presumptive identification of cutaneous propionibacteria can be achieved with litmus milk agar as medium. | 1977 | 577927 |
| active experimental inhibition of cancer by corynebacterium parvum. | it has been demonstrated that 5 microgram corynebacterium parvum (mérieux, lyon) applied i.v. once weekly in mice of the strain c 3 h x swiss albino f 1 after three pregnancies effectively inhibits tumour growth. at this time those mice are 100% at risk. the appearance of tumours in the treated group is significantly delayed. | 1977 | 579449 |
| susceptibility to erythromycin of anaerobes of the genera bacteroides, fusobacterium, sphaerophorus, veillonella, clostridium, corynebacterium, peptococcus, peptostreptococcus. | the minimal inhibitory concentrations (mic) of erythromycin were determined by broth dilution tests for 313 anaerobic strains, most of which were clinical isolates. all the gram-positive anaerobes tested (84 peptococcaceae, including 21 peptostreptococcus anaerobius and 15 peptococcus variabilis; 65 corynebacterium acnes and 29 clostridium strains, including 13 c. perfringens) were sensitive (mic values 0.012 through 3.12 microgram erythromycin/ml); so were 111 cultures of gram-negative anaerobe ... | 1977 | 580038 |
| c. parvum immuntherapy of transplanted rat tumours. | c.parvum (wellcome cn 6134) has been tested for tumour suppression against a range of syngeneically transplanted rat tumours, both carcinogen-induced and of spontaneous origin. subcutaneous growth was not prevented by distant subcutaneous or intravenous injection of the preparation, although growth rates were sometimes depressed or accelerated. in contrast, c. parvum injected in admixture with tumour cells consistently suppressed their growth and with highly immunogenic tumours induced systemic ... | 1977 | 591131 |
| effect of corynebacterium parvum on peripheral blood platelets. | the level of peripheral blood platelets was determined after i.v. injection of corynebacterium parvum in normal c57bl mice and in those bearing the lewis lung carcinoma. twenty minutes after injection of a formalin-killed active strain (cn6134, (cn6134, which inhibited tumour metastases) or a killed inactive strain (cn 5888, which did not inhibit metastases) the number of circulating blood platelets was reduced by 50%. the level of platelets returned to control values by 8 h after the active, an ... | 1977 | 597475 |
| effect of corynebacterium parvum on subcutaneous and skeletal methylcholanthrene sarcoma implants. | 1977 | 598063 | |
| combination chemo-immunotherapy with adriamycin in experimental tumor systems. | 1977 | 598392 | |
| [immunological problems in cancer]. | 1977 | 601267 | |
| the complications of intravenous corynebacterium parvum infusion. | 100 intravenous infusions of corynebacterium parvum were given to thirty-six patients at a dose of 5 mg/m2. fever and rigors occurred in all patients but these acute side effects were acceptable to all but two patients. seventeen patients suffered a delayed fall in blood pressure, which was marked in eight of them but was generally well tolerated. one patient died 18 hr after infusion from extensive myocardial infarction. herpes labialis complicated the first infusion in nine instances, which ma ... | 1977 | 606444 |
| comparative studies on the cell wall composition of some anaerobic coryneforms of varying lympho-reticular stimulatory activity. | anaerobic diphtheroids possessing lympho-reticular stimulatory properties may differ considerably in their peptidoglycan composition. spleen weight-increasing activity of strains directly parallels their antitumour properties. p. granulosum strains, inactive in assays for lympho-reticular stimulation, appear to have a higher cell wall alanine content than most of the p. acnes and p. avidum strains tested. two p. acnes strains, however, had equivalently high alanine ratios and were stimulatory. t ... | 1977 | 608497 |
| studies using labelled c. parvum preparations in mice. | the in vivo distribution of 125i and fluorescein labelled c. parvum, after local and systemic injection mice has been studied. after i.v. injection large amounts were found in the liver, spleen and lungs, with less in the lymph nodes. the distribution after s. c. injection was more restricted; the bulk of inoculum was retained at the injection site and draining lymph node, and only small amounts were found in the liver and spleen. c. parvum was found in bone marrow, but not peritoneal cells afte ... | 1977 | 608498 |
| distribution of technetium-99m labeled corynebacterium parvum in normal and tumor bearing mice. | 1977 | 608499 | |
| distribution of 3h-thymidine-labelled c. parvum in mice. | little is known of the localisation of injected corynebacterium parvum. we therefore developed a method of radiolabelling this vaccine and determined its distribution in the mouse. live c. parvum (wellcome, strain cn 6134) was grown in the presence of 3h-thymidine and subsequently killed by formalin. a high activity, 1-6 x 10(5) cpm/0.1 ml of a 7 mg dry weight/ml concentrated suspension, was obtained. its biological properties (hepatosplenomegaly and antitumour effects) were similar to those of ... | 1977 | 608501 |
| further studies on the enhancement of the antibody response in vitro by c. parvum. | we have shown previously that spleen cells from mice pre-treated with c. parvum give enhanced antibody response when cultured in the presence of thymus-dependent antigens. in order to establish if c. parvum has a similar effect when added in vitro, spleen cells from untreated mice were cultured with c. parvum in marbrook chambers with sheep erythrocytes (srbc) as antigen. at concentrations of 35-140 microgram/ml/20 x 10(6) spleen cells c. parvum enhanced, but at higher concentrations suppressed ... | 1977 | 608502 |
| antibody responses, antitumour antibodies and ig class and subclass levels in c. parvum treated mice. | this paper summarises the results of extensive studies performed in our laboratory during the past three years aimed at establishing the effect of c. parvum administration on humoral immunity in normal mice and mice previously challenged with viable mc fibrosarcoma cells. this treatment was found to (a) increase the response to thymus dependent and independent antigens, (b) result in the production of circulating immunoglobulins which bound to tumour cells and syngeneic tissues in vitro, and (c) ... | 1977 | 608503 |
| monocytosis-inducing activity (mia) of serum in corynebacterium parvum treated mice. | intravenous injection of 548 microgram of c. parvum (lot 0407, mérieux laboratories, france) into c57bl mice produced rapidly appearing monocytopenia which was followed by marked and prolonged monocytosis after the third day. the serum of these animals, collected during the monocytopenic but not the monocytosis phase, showed monocytosis inducing activity (mia) as was demonstrated by the intravenous injection of the serum into normal test mice. serum from normal untreated mice or from mice given ... | 1977 | 608504 |
| cell mediated immunity to corynebacterium parvum and its role in tumor control. | the injection of c. parvum provokes a transient cell-mediated immune response to its own bacterial antigens. during this period a subcutaneous challenge dose results in the appearance of a characteristic delayed type hypersensitivity (dth) skin reaction. if a suspension of syngeneic tumor cells is included in this challenge, they are destroyed in immune but not control animals. similarly, solid tumors of limited size can be made to regress under these conditions. adoptive transfer studies reveal ... | 1977 | 608505 |
| potentiation of anamnestic humoral responses by a single intravenous injection of corynebacterium parvum (c. parvum) in adult rabbits. | 1977 | 608507 | |
| effect of corynebacterium parvum on the immune response of the guinea pig to ovalbumin. | 1977 | 608508 | |
| in vitro anti-tumour properties of peritoneal exudate cells of conventional germ-free and stimulated mice. | adherent cells of peritoneal exudates were obtained from conventional, or from germ-free mice or from mice having received in intraperitoneal infection of a variety of phlogogenic substances such as corynebacterium parvum (c. parvum) (mérieux) 500 microgram, thioglycolate (difco) 3 ml, bayol (esso) 0.50 ml + 0.50 ml culture medium, glycogene 1.2 ml. the cytotoxic properties adherent cells were studied in vitro by the chromium release technique (crt) and their cytostatic properties by the inhibit ... | 1977 | 608509 |
| effects and mode of action of corynebacterium parvum on murine tumour metastases. | the effects of corynebacterium parvum (c. parvum) on lewis lung tumour metastases have been studied. i.v. and i.p., but not s.c. c. parvum significantly reduced pulmonary metastases. when combined with excision of the primary tumour, c. parvum given not more than 2 days before caused slight reduction of metastases, but when given earlier, it caused significant reduction and some mice were cured. metastases were increased by silica or cortisone acetate but were unaffected by trypan blue. the anti ... | 1977 | 608510 |
| effects of surgery and c. parvum on tumour metastases in mice. | surgical operations depress immune responses. the aim of this study was to observe the effects of operation (amputation) on the growth of the lewis lung tumour and its metastases and to see if c. parvum counteracted them. anaesthesia alone, or with amputation, did not affect the growth of the primary tumour but c. parvum depressed it. anaesthesia did not affect the number of pulmonary metastases but amputation caused significant increase. c. parvum inhibited metastases and completely counteracte ... | 1977 | 608511 |
| a comparison of the antitumour activities of glucans and c. parvum. | after i.v. injection of glucans (yeast cell walls, lentinan and pseudonigeran) into cba mice, the peritoneal macrophages became cytostatic to r1 leukemia cells in vitro, and the mice showed resistance to lung nodule formation by i.v. injected t3 fibrosarcoma cells. the glucans were less active than c. parvum. none of the glucans reproducibly acted as an adjuvant when mixed with irradiated tumour cells; nor did they inhibit the growth of a subcutaneous tumour when injected i.v. or directly into t ... | 1977 | 608513 |
| in vivo transfer of antitumor activity by peritoneal exudate cells from mice treated with c. parvum. | we have investigated whether peritoneal exudate cells (pec) from c. parvum (cp) treated (c3hf/bu mice could transfer in vivo the resistance against a syngeneic fibrosarcoma (fsa). inhibition of tumour development and prolongation of survival of recipients were observed when cp-activated pec were admixed with fsa cells before their intraperitoneal (ip) or subcutaneous (sc) injections into normal mice. the antitumour activity increased with the increase of the ratio of effector to target cells. he ... | 1977 | 608514 |
| effects of c. parvum on radiation response of murine tumors. | the effects of intravenous c. parvum (cp) on the efficacy of fractionated gamma-irradiation in treating a fairly immunogenic fibrosarcoma (fsa) and a weakly immunogenic mammary carcinoma (mdah-mca-4) were studied in c3hf/bu mice. tumors were 8 mm in diameter at the start of irradiation. the fsa was exposed to 500 and the mdah-mca-4 to 750 rads daily for 3.6 or 10 days. the administration of 0.25 mg cp varied from 4 days before to 14 days after the start of irradiation. cp greatly augmented radio ... | 1977 | 608515 |
| chemo-immunotherapy of mouse tumours using cyclophosphamide and c. parvum. | treatment of a chemically induced mouse solid fibrosarcoma using either non-specific (c. parvum 350 mu i.v.), or specific active (s.c. c. parvum mixed with 5.10(5) irradiated tumour cells) immunotherapy, 4 days after a single dose of cyclophosphamide (200 mg/kg) was synergistically more effective than either c. parvum or drug treatment alone. a contributory factor may be that cyclophosphamide pretreatment has been shown to potentiate the specific antitumour immunity that arises from c. parvum in ... | 1977 | 608516 |
| increased sensitivity of c. parvum treated mice to ionizing whole body irradiation. | we have investigated whether c. parvum (cp)-induced stimulation of hematopoiesis affects the survival of mice exposed to the whole body irradiation (wbi). c3hf/bu mice treated with cp exhibit an increased hematopoietic colony forming activity in their spleens and blood, but not in their bone marrow, as determined by the exogenous spleen colony assay. also, cp-treated c3hf/bu as well as cba mice show an increase in their endogenous colonies. this increased hematopoietic activity caused by cp trea ... | 1977 | 608517 |
| experimental evaluation of nonspecific immunostimulation and chemotherapy in the intracranial tumor-bearing fisher rat. | one hundred sixty rats bearing intracranial tumors were divided into groups of 10 to evaluate c-i interval +, effect of chemotherapy alone (bcnu), chemotherapy and c. parvum, and c. parvum alone in the rat tumor model. all therapy was administered intraperitoneally: bcnu -5.2 mg/kg (40% of ld10) on the 9th and 16th post tumor implant day, and c. parvum-1.4 mg regardless of the body weight and the 6th or 23rd day and 6th and 23rd post tumor implant day. an additional group received bcnu on the 9t ... | 1977 | 608518 |
| the effect of pretreatment with corynebacterium parvum on the growth of a chemical induced transplanted murine tumor. | unspecific immunostimulation with or without specific tumor immunotherapy may well contribute to the control of minimal residual cancer. corynebacterium parvum (c.p.) has been shown to raise the level of immunocompetence in tumor bearing animals. experiments are reported, which aim at an evaluation of optimal conditions for an immunostimulation with c.p. prior to the transplantation of balb/c meth a ascitis. using different dosages, routes of injection and schedules of vaccination it was found, ... | 1977 | 608519 |
| effects of bcg and c. parvum treatment on human melanoma xenografts. | cba mice rendered immunodeficient by thymectomy, potentially lethal gamma-irradiation and reconstitution with bone marrow cells were used to grow a wide variety of human tumours as subcutaneous implants. samples of human melanoma obtained at surgery were successfully passaged by transplantation and produced rapidly growing tumours, some of which metastasized to lung, lymph nodes and the para-aortic node; this system was used as a model for the study of immunotherapy of melanoma. preliminary resu ... | 1977 | 608525 |
| the local effect of intravesical corynebacterium parvum in the dog. a preliminary study. | high doses of c. parvum introduced in the bladder of the dog provoke changes in the submucosa. the significance and importance of these modifications should be investigated. | 1977 | 608526 |
| comparison of bcg and c. parvum preparations for adjuvant contact therapy of a rat sarcoma. | 1977 | 608529 | |
| histological changes of intravascular coagulation in mice resulting from intravenous injection of c. parvum. | a histological study was made of liver and other tissues of mice at intervals after injection of c. parvum. as early as 20 min after injection occasional thrombi surrounded by polymorphs were seen in the alveolar capillaries. a general thrombosis rapidly developed in the hepatic vessels with consequent hepatic necrosis. thrombi also developed in splenic vessels. this intravascular coagulation was prolonged, lasting at least 7 days. there was evidence that fresh thrombi were being formed througho ... | 1977 | 608532 |
| effects of corynebacterium parvum vaccine on drug metabolism in the mouse. | mice of the cba strain were given a single intraperitoneal injection of c. parvum vaccine at 50 mg/m2. there followed a progressive increase in liver weight and in the duration of hexobarbitone sleeping time, accompanied by a marked decrease in liver microsomal protein and in cytochrome p-450/mg microsomal protein. that is to say, content of cytochrome p-450 was reduced out of proportion to the apparent loss of endoplasmic reticulum. these changes were paralleled by decreases in microsomal o-dem ... | 1977 | 608533 |
| effects of bcg and corynebacterium parvum on immune reactivity in melanoma patients. | sixteen patients with disseminated melanoma were immunised with either bcg (8 cases) or c. parvum (8 cases) on three occasions at 21 day intervals. blood for assay was taken immediately before the first immunisation and weekly for eight weeks thereafter. total white count tended to increase but little change was seen in lymphocyte and monocyte counts. serum igg increased after bcg but not with c. parvum, serum iga and igm did not alter. the 'e' rosette % did show some increase mainly after c. pa ... | 1977 | 608536 |
| the effect of corynebacterium parvum on human effector cells in peripheral blood. | 1977 | 608538 | |
| in vitro and in vivo effects of corynebacterium parvum on lymphocyte transformation. | using a range of doses the effect of c. parvum on the in vitro response of lymphocytes to pha was studied. c. parvum was not found to be mitogenic itself when added to unfractioned lymphocyte cultures from normal donors and patients with breast cancer, nor did it effect the response to pha in these cultures except at the highest dose (20 microgram/100,000 cells) when it was inhibitory. 21 patients with breast cancer treated with c. parvum were assessed by their in vitro response to pha prior to, ... | 1977 | 608539 |
| the effect of intravenous infusion of corynebacterium parvum on an immune profile of women with breast cancer. | an immunological profile has been measured in 21 patients with advanced breast cancer who were treated with c. parvum (wellcome strain cn6134). thirteen patients received a single i.v. dose of 15 mg of c. parvum and 8 received 4 mg i.v. on 5 successive days. the "profile" was recorded before and 7-10 days after treatment and included measurement of total white count, absolute lymphocyte and monocyte counts, pha response, b and t cell percentages. dncb and mantoux skin tests, immunoglobulin class ... | 1977 | 608540 |
| further studies on the serological effects of c. parvum immunotherapy in cancer patients. | previous serological studies undertaken in our laboratory have shown that the repeated administration of small doses of c. parvum to a small group of cancer patients resulted in a consistant increase in the levels of igg (especially the igg2b subclass), the development of antibodies to c. parvum and the transient appearance of 'rheumatoid factor like' substances in the serum (br. j. cancer, 32, 310, 1975). in the present paper we report the results of similar studies in small numbers of (a) inop ... | 1977 | 608542 |
| first impressions of i.v. c. parvum in patients with solid tumours. | 6 patients with solid tumours (4 malignant melanomas, one fibrosarcoma, one osteogenic sarcoma) received i.v. c. parvum alone or in combination therapy (radiotherapy, levamisole and/or vitamin a). the single doses of c. parvum ranged from 5.0-7.5 mg/m2; no. of doses ranged from 1-8; interval between doses ranged from 2-140 days. 2 patients with malignant melanoma had no measurable disease, one of them (stage i) still has no evidence of disease. the patient with fibrosarcoma appeared to have a mi ... | 1977 | 608543 |
| experience with the quality control testing of c. parvum suspension for clinical trial. | the control of c. parvum suspension presents special problems. the intended application of this preparation is in a therapeutic area where clinicians are accustomed to using defined chemical entities the biological activity of which are usually predictable according to weight of active principle administered, the route and number of doses. but the essential character of c. parvum is that of a vaccine in which the character of the active principle or principles is not clearly identified and can v ... | 1977 | 608544 |
| toxic and immunologic side effects of daily c. parvum-infusion in treatment-resistant cancer patients. | daily increasing intravenous doses of corynebacterium parvum (c.p.) up to 5 mg/m2 i.v. x 10-14 days were given to 6 patients with widespread metastatic neoplastic diseases resistant to radio- and chemotherapy. the immunotherapy treatment-cycles were evaluated for toxic and immunologic side effects and also for possible clinical benefit to the patients. immunotherapy with i.v.-c.p. was moderately well tolerated. subjective discomfort for the patients (headache, chills, nausea) was not better tole ... | 1977 | 608546 |
| a survey of patients' reactions to intravenous corynebacterium parvum therapy. | a survey was made of patients' reactions to high dose (21 mg) corynebacterium parvum therapy given intravenously over four hours. the patients completed a pro forma. rigors were the commonest side effect complained of being present in nearly all patients (24/25) and being very severe in one-third (10/25). other problems were nausea (15/25), vomiting (17/25), bone pain (12/25) and headaches (12/25). one-third also usffered with other less common side effects. overall, patients felt the side effec ... | 1977 | 608547 |
| intra-tumour c. parvum therapy in gastric carcinoma; a pilot study. | in a preliminary and toxicological study, eight patients with carcinoma of the stomach were treated by corynebacterium parvum immunotherapy prior to surgical excision. killed c. parvum suspension was injected at multiple sites directly into the tumour mass with the aid of fibre-optic gastroscope at doses of 1.5 mg, 4 mg or 8 mg. each patient received two injections of the same dose with an interval of 14 days. the second injections were made 14 to 18 days prior to surgery. no chemotherapy was ad ... | 1977 | 608548 |
| mouse tumour tests for quality control of c. parvum preparations. | description of two mouse tumor tests selected to control the quality of c. parvum pilot productions: transplanted ehrlich's ascitic tumor in inbred swiss mice and transplanted yc8 ascitic tumor in isogenic balb/c mice. the results obtained during three years of control are analyzed, particularly accuracy, long range adequacy and reproducibility of tumor challenges and c, parvum stimulations. the effects of some parameters of the tumor tests, e.g. dose-responses, treatment schedules, tumor-host r ... | 1977 | 608550 |
| c. parvum skin testing antigen: study on guinea pig model. | a skin-testing antigen produced from c. parvum has been developed for exploring cell-mediated immunity and specially c. parvum specific cell-mediated immunity by delayed cutaneous hypersensitivity (dch) reaction. the dch antigen and the techniques of intradermal injection and multiple puncture are described. dch reactions are carried out in c. parvum specifically sensitized guinea pigs: sensitization procedure and adjuvant (ifa and cfa) effects are reported. measures of dch reactions for differe ... | 1977 | 608551 |
| proposals for quality control methods of bacterial vaccines for immunostimulation. i. general considerations. | control methods for this type of vaccines include tests on identity, absence of contaminating microorganisms and safety which are required for any vaccine. in addition, for the control of vaccines for immunostimulation in cancer therapy some special methods for safety and potency testing are required. some assays are proposed, such as stimulation of lymphocytes in vivo and in vitro, stimulation of macrophages (listeria clearance) in mice and the prophylactic and therapeutic tumor model in mice. ... | 1977 | 608552 |
| the effect of intradermal administration of corynebacterium parvum on the immune response to hepatitis bs antigen. | the immunopotentiating effect of the intradermal administration of a course of four doses (0.25 ml) of a standard suspension of killed c. parvum (2 mg/ml) was studied in a group of 10 asymptomatic chronic hepatitis b surface antigen (hbsag) carriers, as well as in 11 persons with antibodies to hbsag (anti-hbs) and six without hbsag or anti-hbs. hbsag, anti-hbs, and leukocyte migration inhibition (lmi) studies were performed in pre- and post-inoculation blood samples. c. parvum produced a substan ... | 1977 | 609027 |
| measurement of phagocytic activity of reticuloendothelial system (res) by intralipid: effect of c parvum treatment. | 1977 | 617547 | |
| [study of the tolerance of a submucous injection of coryné parvum in the dog bladder]. | 1977 | 617754 | |
| effect of bcg and c. parvum on in vivo listeria clearance and tumor growth. comparative studies in normal and congenitally athymic (nude) mice. | clinically, it is important to know whether agents used for immunostimulation require the presence of functional thymus-derived (t) cells. previous studies showed that both bcg and c. parvum induced a macrophage-dependent enhanced in vivo listeria clearance and in vivo inhibition of a fibrosarcoma induced by 20-methylcholanthrene. these two models were re-evaluated in congenitally thymusless (nude or nu/nu) b10lp mice lacking functional t cells. in nu/nu mice, (1) bcg failed to enhance listeria ... | 1977 | 415917 |
| the effect of corynebacterium parvum on the proliferation of monocyte precursors in the bone marrow of mice. | the anti-tumour activity of c. parvum is thought to be mediated via the monocyte/macrophage system (scott, 1974). these cells originate from rapidly dividing precursors in the bone marrow and it might be at this level that c. parvum exerts its action. to test this hypothesis bone marrow t0 swiss mice has been cultured according to the method of bradley and metcalf (1966), which gives an index of the number of proliferating macrophage precursor cells at the time of sacrifice. experiments were set ... | 1977 | 415919 |
| conditions favouring the selection of either specific or non specific c. parvum-mediated, systemic antitumour immunity in mice. | accumulated data suggest that one of two antitumour mechanisms of c. parvum may predominate depending on the route of injection of c. parvum and its distribution in relation to the tumour. after systemic c. parvum the mechanism is considered to be immunologically non specific (i.e. not requiring tumour specific antigens) and mediated by c. parvum activated macrophages. after local injection of c. parvum the interaction (direct or lymph node mediated) between c. parvum and tumour specific antigen ... | 1977 | 415921 |
| proposals for quality control methods of bacterial vaccines for immunostimulation. iii. effect of bcg and c. parvum on in vivo listeria clearance and tumor growth. | two quality control methods for bcg and c. parvum are described. first, in vivo macrophage dependent-spleen clearance of listeria monocytogenes in inbred b10lp mice. bcg and c. parvum were administered intravenously prior to listeria inoculation (a prophylactic model). conditions for enhanced listeria clearance including dose, route and time interval were described for each vaccine. next, a tumor model was developed: i.e. a fibrosarcoma, chemically induced by 20-methylcholanthrene in inbred balb ... | 1977 | 415924 |
| [potentiation of immunologic memory by corynebacterium parvum and its mechanism]. | immune response to bovine serum albumin (bsa) at dose of 2,50 mg/kg which is rather a weak immunogen in rabbits, when given intravenous was highly potentiated when the animals received a previous single intravenous infection of 2 mg/kg of c. parvum, followed by subsequent bsa anamnestic challenges for several months. thus, the antibody amounts synthesized following the 1st anamnestic injection (3 weeks) were 0,260 mg/ml in the control versus, 0,800 mg/ml in the c. parvum pretreated groups; follo ... | 1977 | 417841 |
| effect of sensitization with propionibacterium acnes on the growth of listeria monocytogenes and treponema pallidum in rabbits. | sensitization of rabbits with propionibacterium acnes, a nonspecific stimulant of the reticuloendothelial system, was investigated as a means of enhancing resistance to treponema pallidum. a single i.v. dose of p. acnes given 3 or 7 days before challenge with listeria monocytogenes was capable of suppressing the growth of the heterologous organism, whereas a single i.v. dose 24 hr or 14 days before challenge was not. reactivation via i.v. elicitation with p. acnes 14 days after sensitization (1 ... | 1977 | 401511 |
| a special report: four-year study of a boy with combined immune deficiency maintained in strict reverse isolation from birth. | a 4-year study of a boy with combined immune deficiency is presented, and the impact of this disease on various aspects of his growth and development is examined. there is no evidence of immune deficiency in either parent or in the genetic background on the maternal side. three children of a brother of the mother's father may have had immune deficiencies but two have grown to be teenagers with no problems. another died. at autopsy, however, lymph nodes appeared normal. the deceased older brother ... | 1977 | 401538 |
| effect of bacterial products on inflammatory reactions in the dental pulp. | culture filtrates (extracellular components) and material obtained from disintegrated cells (intracellular components) of cultured plaque bacteria were studied for their capacity to induce inflammatory reactions in the dental pulp. class v cavities were prepared on the buccal surface of 94 teeth: 42 test and 52 control teeth in six adult monkeys. lyophilized bacterial components were sealed into the test cavities either alone or following an 8-h topical application of a solution of the same comp ... | 1977 | 402688 |
| antitumor activity of a brucella abortus preparation. | mice injected intraperitoneally with sarcoma-180 cells develop ascites and eventually die. intraperitoneal injection of a nonviable, aqueous... ether-extracted brucella abortus preparation (bru-pel) as early as 7 days before or as late as 7 days after injection of tumor cells significantly inhibited development of ascites and protected against death. bru-pel was not effective if injected after ascites was grossly apparent. bru-pel was significantly more active than a corynebacterium parvum prepa ... | 1977 | 404249 |
| bacteremia after upper gastrointestinal endoscopy. | during 24 months, 200 upper gastrointestinal endoscopies were performed on 193 patients. blood cultures were obtained before and five and 30 minutes after the procedure using thiol (50 ml) and trypticase soy broth (100 ml) media. the mean endoscopic time was 34 minutes. sixteen patients developed bacteremia (8%). twelve groups of microorganisms were detected in positive blood cultures: streptococcus (5 species), lactobacillus sp, veillonella alcalescens, staphylococcus aureus, staph epidermidis, ... | 1977 | 404974 |
| diphtheroid osteomyelitis. | isolates of either corynebacterium diphtheriae or propionibacterium acnes from osteomyelitis are not necessarily contaminants, as shown by the cases of three patients who had bone and joint infections in which these organisms were pathogenic (one in pure culture and two in mixed cultures). previous operation or other factors that compromise host resistance create the setting for these opportunistic organisms. penicillin with or without streptomycin is the treatment of choice, but if penicillin o ... | 1977 | 405396 |
| bacteraemia in asymptomatic human subjects. | 1977 | 405961 | |
| [radioprotection conferred by corynebacterium parvum against the lethality caused by x irradiation at sublethal and lethal doses in the mouse]. | intraperitoneal injection of corynebacterium parvum (c. parvum) into balb/c mice produces a protection against toxicity or lethality provoked by ionizing radiation (750 r and 950 r). survivals reaching nearly 90 days have been recorded. | 1977 | 406088 |
| ovarian cancer: use of multiple modality programs involving surgery, radiation therapy and chemotherapy. | appreciating the past reports of effectiveness for various therapeutic modalities in ovarian cancer, the gynecologic oncology group activated eight protocols. three involved epithelial lesions with randomized multimodality trials alone or in combination. the other protocols were devoted to registration of rare tumor case reports. conclusions are still difficult to reach due to inconsistencies in pathologic diagnoses and deficiencies in radiation therapy, chemotherapy and surgery inherent in the ... | 1977 | 406985 |
| antitumor activity of propionibacterium acnes (corynebacterium parvum) and isolated cytoplasmic fractions. | the tumor-inhibitory effect of an intralesional injection of propionibacterium acnes was of limited duration ("finite"). our model was the dba/2 syngeneic mouse injected with p815 mastocytoma cells (5 x 10(5)) into each rear footpad; only the left was treated, leaving the right as a "pseudometastasis." the finite effect occurred at approximately 21 days after the first treatment. subsequent i.p. treatments with p. acnes did not alter this effect, although they increased mean survival time. with ... | 1977 | 409491 |
| reticulostimulating properties of killed vaccines of anaerobic coryneforms and other organisms. | vaccines prepared from 115 strains of anaerobic coryneforms and other organisms were tested in mice for their reticulostimulating ability as judged by the degree of spleen hypertrophy produced after ip injection. almost all vaccines caused a statistically significant increase in spleen weight, but the ability to produce spleen ratios (test mean wt:control mean wt) of 4 or more was confined to propionibacterium acnes and p. avidum strains. p. acnes, type ii, gave high spleen ratios more frequentl ... | 1977 | 411938 |
| effect of the combination of corynebacterium parvum and levamisole on murine tumors. | 1977 | 413718 | |
| organ distribution of corynebacterium parvum labeled with iodine-125. | administration of iv, ip, single sc, multiple sc, and footpad injections of [125i]corynebacterium parvum in mice revealed different patterns of radioactive vaccine distribution in various organs. high deposition and retention were found in the liver, spleen, and gastrointestinal tract and less in the lungs, kidneys, thymus, and bone marrow. control animals given 125i showed very rapid clearance of the isotope and no retention in the organs. the pattern of distribution of [125i]c. parvum could be ... | 1977 | 833877 |