Publications

propionibacterium acnes-mediated humoral immune responses to tumor-specific antigens on rat liver cells transformed in vitro by chemical carcinogens.	effects of propionibacterium acnes on production of antibodies against tumor-specific membrane antigens were investigated in syngeneic inbred bd iv and bd vi rats. bd rat liver cell lines transformed in vitro by chemical carcinogens were used as target cells for tumor-specific antigens. by membrane immunofluorescence, antibodies against these rat liver cell lines were detected in syngeneic bd rat sera. antibodies were produced in syngeneic rats under the adjuvant effect of heat-killed p. acnes o ...	1978	281560
combined use of local irradiation and corynebacterium parvum in the treatment of the murine line 1 lung carcinoma.		1978	204955
synergistic lysis of erythrocytes by propionibacterium acnes.	sheep and human erythrocytes, partially processed by staphylococcus aureus or clostridium perfringens, were susceptible to lysis in the presence of propionibacterium acnes. p. acnes liberated a lipase that was detected on tween 80 agar and also on phospholipase c-precipitated egg yolk agar. such a lipase might have contributed in the process of an intensified cellular lysis. similar reactions were attempted with lactobacillus acidophilus, known to possess a nondiffusible lipase, and failed to pr ...	1978	212450
defective in vitro lymphoproliferative responses to herpes simplex virus in patients with frequently recurring herpes infections during the disease-free interval.		1978	213220
effect of silver nitrate application on the conjunctival flora of the newborn: and the occurrence of clostridial conjunctivitis.	newborn conjunctival cultures were obtained from 35 babies prior to silver nitrate application and 48 hours later. on initial culture, 46 facultative bacteria and 27 anaerobes were recovered; 48 facultative and 18 anaerobes were recovered after 48 hours. haemophilus vaginalis, bacteroides species and anaerobic cocci decreased in numbers, whereas s. epidermidis, micrococcus and propionibacterium acnes increased during this time interval. clostridial species were isolated from two cases who develo ...	1978	216788
effects of corynebacterium parvum on murine myeloid leukaemia.	the effects of c. parvum on rfm/un myeloid leukaemia were studied. mice inoculated with 7.0 mg but not 0.7 mg c. parvum i.p. survived significantly longer than untreated leukaemic mice (p less than 0.001). administration of silica abrogated the effects of c. parvum, whilst polyvinyl pyridine-n-oxide prevented the inhibitory effects of silica. these studies demonstrate that a single large dose of c. parvum, either before or after leukaemic-cell passage, can significantly prolong the survival of r ...	1978	217398
binding of microorganisms to the macrophage plasma membrane; effects of enzymes and periodate.	the nature of the binding of c. parvum organisms to the surface of glass-adherent mouse peritoneal exudate cells in vitro was studied using pretreatment of the cells with various enzymes and periodate. trypsin, pronase, beta-galactosidase, phospholipases a, c and d and periodate all caused a decrease in binding to 40-60% of untreated control. neuraminidase led to a 30% increase in binding. the binding ability returned to normal after 1 h at 37 degrees in culture medium following exposure to all ...	1978	205234
detection of alcohols and volatile fatty acids by head-space gas chromatography in identification of anaerobic bacteria.	a head-space gas chromatographic technique for the analysis of volatile bacterial metabolites is described. bacteroides fragilis, clostridium perfringens, and propionibacterium acnes, cultured in a glucose-containing peptone yeast extract medium, were studied. the head-space technique was compared with the injection of the complete liquid culture medium, and solvent extracts thereof, into the gas chromatograph. volatile fatty acids could be detected by all three methods, whereas alcohols produce ...	1978	203602
protection of mice against viral infection by corynebacterium parvum and bordetella pertussis.	mice could be significantly protected against infection with herpes simplex virus (hsv) by i.p. or i.v. injection of killed corynebacterium parvum 7 days before infection. this protection was seen in inbred strains of mice with a different degree of sensitivity to hsv and after both i.p. and i.v. infection. resistant mice immunosuppressed by x-irradiation and showing an increased susceptibility to hsv could also be protected by a previous injection of c. parvum. elevated levels of interferon wer ...	1978	212522
complement activation in acne vulgaris: in vitro studies with propionibacterium acnes and propionibacterium granulosum.	to better define the role of bacteria in inflammatory acne vulgaris, we have investigated the ability of four strains of propionibacterium acnes and three strains of propionibacterium granulosum to activate complement. complement activation was assayed by incubating normal human serum with varying concentrations of each strain and measuring residual total hemolytic complement activity. when serum was tested unaltered, p. acnes strains were approximately threefold more potent than an equal weight ...	1978	153333
acne: current concepts.		1978	153517
ultrastructural basis for the assay of topical acne treatments. transmission and scanning electron microscopy of untreated comedones.	after two decades of using systemic antibiotics as a main treatment for acne, emphasis is again being placed on topical agents. thus, it is highly desirable to have a procedure whereby the activity of the various compounds can be evaluated by direct visualization. scanning electron microscopy combined with transmission electron microscopy provide the tools for such in assay. this study describes the ultrastructure of untreated comedones and provides the baseline or control data necessary for tes ...	1978	151693
prostaglandin-like substances in propionibacterium acnes.		1978	152714
cellular immunity to p. acnes in the normal population and patients with acne vulgaris.	patients with varying degrees of acne, acne-free adult controls and samples of cord blood were investigated for cell mediated immunity to p. acnes using a leukocyte migration inhibition test. despite the fact that the mean migration index tended to decrease with acne severity, only the patients with severe acne showed cell-mediated immunity. it is suggested that when cellular immunity arises it is a late event which may contribute to inflammation but is probably not a factor in its initiation.	1978	150284
local microwave hyperthermia (43 degrees c) and stimulation of the macrophage and t-lymphocyte systems in treatment of guerin epithelioma in rats.		1978	146340
acne.		1978	147953
[polymorphous juvenile acne (author's transl)].	many factors may be involved in the pathogenesis of acne, the most important of them lie in the sebaceous follicle, in disturbances of the cornification of the follicular channels and in the bacterial flora of the hair follicles. the latter consists of a yeast (pityrosporon ovale), coagulase-negative aerobic staphylococci and propionibacterium acnes. p. acnes is found in the depth of the follicle. it is of particular importance for the pathogenesis because it produces a lipase which releases fat ...	1978	148004
skin surface glycerol levels in acne vulgaris.	free glycerol would be expected from biochemical considerations to be an end product of lipolysis of sebum triglycerides. glycerol was measured in skin surface washings of acne vulgaris patients, in acne vulgaris patients treated for at least 3 mo with oral tetracycline and in control subjects. surface glycerol in untreated acne subjects was significantly less than that expected theoretically, whereas the amounts of such glycerol in treated acne patients and in control subjects closely approache ...	1978	148480
complement activation by corynebacterium acnes.		1978	148901
[dandruff (pityriasis simplex capillitii)].	in this review of new studies about dandruff, methods for clinical (subjective) evaluation and quantitative (objective) appraisal of dandruff are described. current concepts about histopathology, cytology, biochemistry and etiopathogenesis of this common condition of the scalp are detailed.	1978	149094
on the propionibacteria in the pilosebaceous ducts of uninvolved skin of acne patients.	in 24 persons with a severe inflammatory acne and 48 control subjects, bacteria were sampled from the sebaceous gland exretory ducts with the glass sampling head method according to holland et al. after anaerobic culture bacterial counts were performed. the total numbers of p. acnes and the frequency of detection of p. granulosum were determined. the bacterial counts of p. acnes were almost idendical in the two collectives. p. granulosum was detected at a significantly higher frequence in the ac ...	1978	150822
dermatology: acne vulgaris.		1978	150871
nutritional requirements of anaerobic coryneforms.	the nutritional requirements of three species of anaerobic coryneforms and their serotypes (propionibacterium acnes types i and ii, p. avidum types i and ii, and p. granulosum) were determined. strains of p. avidum would consistently grow to a transmittance of 1 to 3% at 560 nm in a basal salts medium supplemented with glucose, pantothenate, biotin, thiamine, and 12 amino acids (alanine, arginine, cysteine, glutamine, glycine, histidine, isoleucine, methionine, phenylalanine, serine, tyrosine, a ...	1978	151095
[porphyrinsynthesis of propionibacterium acnes in acne and seborrhea (author's transl)].	the porphyrin productions of p a.-strains, isolated on the one hand from inlfammatory acne lesions, on the other hand from sebaceous follicle filaments from 10 persons each were compared quantitatively and qualitatively, after the appropriate material had been pooled, with respect to the acne strains one could observe a somewhat increased porphyrin production as well as the discharging of a precentually greater portion of porphyrins to the surrounding material. when separated by tlc the acne mat ...	1978	148872
effect of propionibacterium acnes or bcg on enzyme activities in spleen lymphocytes of donryu strain rats.	immunopotentiated rats, which were injected with propionibacterium acnes or bcg, had the 50% survival twice as long as those in untreated controls after intravenous inoculation of sato lung carcinoma (slc) cells. the amount of labeled tumor cells in the lung of the adjuvant-treated rats decreased significantly in the first 20 hr after intravenous injection of 51cr-labeled tumor cells compared to that of control animals. the elevated activities of atpase and acid phosphatase in the whole nucleate ...	1978	149684
an analysis of conditions allowing corynebacterium parvum to cause either augmentation or inhibition of natural killer cell activity against tumor cells in mice.	we have analyzed the impact of in vivo administration of corynebacterium parvum on the mouse immune system against murine tumors, using the natural cytotoxic ability against tumors of normal mouse lymphoid cells as a baseline. a striking difference was found depending on the route of administration. intravenous inoculation of bacteria would result in a significant decrease or sometimes complete abolition of natural cytotoxicity toward tumor cells of the spleen cells of treated mice. on the other ...	1978	149772
the chemoattractant properties of comedonal components.	acculation of clusters of polymorphonuclear leukocytes (pmn) along the periphery of the walls of comedones (predominantly of the closed variety), has been described as the first change marking the transition of quiescent, noninflamed lesions in acne, into inflammatory ones. the present study analyzed the chemoattractant properties of different comedonal components for human pmn in an effort to evaluate the potential significance of these substances in stimulating the chemotactic response of pmn ...	1978	152335
analysis of the water soluble extract of comedones.	the water soluble fraction of 713 open comedones, pooled from both the face and back of 47 subjects representing all grades of acne, were analyzed for total protein content, carbohydrate content, and for identification of specific proteins. in the water soluble fraction, the protein content represented 11.5%, and carbohydrate content 0.2% of the total comedonal crude weight. esterase and hyaluronidase activity was demonstrated. propionibacterium acnes antigenic material, serum albumin, and serum ...	1978	152336
hepatic arterial infusion of corynebacterium parvum and chemotherapy.		1978	152477
[gram-positive bacteria as adjuvants (author's transl)].	gram-positive bacteria or their constituents influence the immune response in various ways. for instance: listeria monocytogenes cellwall fraction acts as b-cell mitogen, in this way enhancing a humoral immune response. corynebacterium parvum acts as a macrophage stimulant evoking maximum macrophage activation. bcg, among other things, leads to an enhancement of a t-cell response to unrelated antigens. the hypothetical therapeutic consequences are discussed.	1978	96006
protection against chemotherapy toxicity by iv hyperalimentation.	a prospective randomized trial was conducted comparing the addition of iv hyperalimentation (ivh) to corynebacterium parvum, isophosphamide, and adriamycin (cia) chemoimmunotherapy in 26 patients with extensive squamous cell lung cancer. thirteen patients were entered in each treatment arm of the study and ivh was administered before and after the first course of cia for a total of 31 days. the major dose-limiting toxic effect of cia was leukopenia. less myelosuppression was observed for the pat ...	1978	99235
prostaglandin synthesis in spleen cell cultures of mice injected with corynebacterium parvum.		1978	102430
pharmacologic factors and manipulation of immunity systemic adjuvants in cancer therapy.	because of the experimental and clinical studies which have been extensively conducted with bacillus calmette-guérin (bcg) as a systemic adjuvant in cancer immunotherapy, we have analyzed the main factors and conditions which determine its beneficial action and have underlined some of these (eg, the dose factor which controls the amplification of suppressor cells which is probably responsible for failures and even the possible tumor-enhancing effect of immunotherapy). knowing those factors and c ...	1978	103616
adjuvant chemotherapy or chemoimmunotherapy in the management of primary malignant melanoma of level iii, iv, or v.		1978	111323
[immunotherapy today. ii. immunostimulating therapy].		1978	93770
adjvant treatment of tongue and floor of the mouth cancers.	since january 1974, 95 patients with anterior tongue and floor of the mouth cancers were included in a randomized trial. after stratification according to staging and initial treatment, one-third of the patients received chemotherapy for 2 years (methotrexate 400 mg followed by citrovorum factor 100 mg + bleomycin 60 mg/week, during the first 15 weeks), one-third of the patients received immunotherapy with weekly c. parvum injections during 2 years, while the remaining third did not receive any ...	1978	88754
abscesses of the frontal lobe of the brain secondary to covert dental sepsis.	the bacterial species found in pus aspirated from brain abscesses in two patients were typical of those found in dental sepsis. subsequently apical-root abscesses were demonstrated in the upper jaws of both patients. this evidence strongly suggests that these cerebral abscesses were secondary to dental sepsis which could have spread from the teeth to the frontal lobes by several possible antaomical pathways.	1978	79867
role of mononuclear infiltrating cells in pathogenesis of hepatitis.	mice that have been injected with corynebacterium parvum have mononuclear-cell infiltrates in the liver lobules. in such mice a small dose of lipopolysaccharide endotoxin produced a lethal hepatitis, with high serum-transaminase concentrations, glycogen depletion, and hypoglycaemia. it is suggested that lipopolysaccharide triggers the release from the infiltrating mononuclear cells of factors toxic for hepatocytes. similarly certain parasitic and virus infections and graft-versus-host reactions ...	1978	80531
possible mechanisms underlying the induction of cytotoxic macrophages by corynebacterium parvum: in vitro induction of cytotoxicity in normal macrophages by immune lymphocytes.		1978	81874
corynebacterium parvum and hyperthermia.		1978	82029
malignant angioendothelioma--effect of immunotherapy with corynebacterium parvum.		1978	83086
treatment of acne vulgaris with topically applied erythromycin and tretinoin.	a twice daily application of 2% erythromycin base in hydroalcoholic solution accompanied by once daily use of 0.05% tretinoin (retinoic acid) solution was substantially more effective than tretinoin or erythromycin alone for treatment of inflammatory acne of moderate severity. therapeutic enhancement by this combination can be attributed to the different modes of action, erythromycin acting chiefly by suppressing propionibacterium acnes, while tretinoin is comedolytic. in addition, by altering t ...	1978	83088
[immunostimulation].		1978	84450
aerobic and anaerobic bacteriology of acute otitis media in children.	tympanocentesis and aerobic and anaerobic cultivation of the middle-ear fluid obtained was performed through one or both tympanic membranes of 62 children with acute otitis media. aerobic bacteria alone, predominantely pneumococcus and hemophilus influenzae, were isolated from 57% of patients; anaerobic organisms alone, most commonly propionibacterium acnes and peptococcus, from 15%. thirteen percent yielded mixtures of aerobes and anaerobes, and several had multiple aerobic or anaerobic agents. ...	1978	22590
complement activation by propionibacterium acnes and bacteroides melaninogenicus.		1978	33641
the role of bacteria in acne vulgaris: a new approach.		1978	32979
effect of immunomodulators on thymocyte suppressive activity in mice.		1978	28950
resistance to marek's disease. effect of corynebacterium parvum and marek's tumor cell vaccines on tumorigenesis in chickens.	a study of nonspecific stimulation of the avian immune system with corynebacterium parvum and specific stimulation with marek's tumor cell vaccines revealed that nonspecifically stimulated outbred white leghorn-type cockerels had higher incidences of tumors than did controls. a study of tumor cell cytotoxicity of sera from marek's disease virus exposed birds indicated that humoral factors may play some role in tumor resistance.	1978	24754
[action of corynebacterium parvum on the activity of glycosidases and proteases of peritoneal macrophages in the mice].	glycosidase and peptidase of non-treated mouse peritoneal macrophages were characterized. the enzymatic activities of corynebacterium parvum stimulated mouse macrophages were compared to those of macrophages obtained from non-treated animals. all the enzymatic activities, but beta-c-galactosidase, were higher in stimulated mouse macrophages.	1978	102445
[effect of corynebacterium parvum on the glycosidases in guinea pig alveolar macrophages. role of the way of introduction (author's transl)].		1978	111745
studies on the regulation of lymphocyte reactivity by normal and activated macrophages.		1977	67900
immunochemotherapy in 34 cases of oat cell carcinoma of the lung with 19 complete responses.	thirty-four previously untreated patients with oat cell carcinoma of the lung were treated with a myelotoxic combination of cyclophosphamide, adriamycin, methotrexate, ccnu, and corynebacterium parvum (regimen a) every 4 weeks, interspersed with a non-myelotoxic combination including bleomycin, vincristine, dehydroemetine, and corynebacterium parvum (regimen b) weekly the other 3 weeks or when hematologic toxicity prohibited administration of regimen a. hematologic toxicity was frequent but was ...	1977	68827
[progress in medicine in individual presentations, xi. modern forms of therapy in acne].	several pathogenetic factors contribute to the development of acne vulgaris. these include genetic predisposition, hormonal influences, increasing sebaceous secretion, bacterial colonization of the follicle and keratinization defects in the follicular epithelium. modern acne therapy can take specific forms on the basis of recent research on pathogenesis. sebostatic therapy can be performed by the topical application of benzoyl peroxide or the systemic administration of hormones (oestrogens, anti ...	1977	73259
the bacteriology of skin cysts.	thirty-nine clinically uninflamed cysts of the three most common varieties, epidermoid cysts, trichilemmal cysts and steatocystoma multiplex were removed under sterile conditions and the contents cultured under aerobic and anaerobic conditions. seventy-three percent of epidermoid cysts grew significant numbers of organisms whereas none of the trichilemmal cysts did so. the organisms found were the common skin commensals, staphylococcus epidermidis biotype i, anaerobic gram positive cocci of the ...	1977	17428
bacteriocin-like activities of human dental plaque flora against oral anaerobic microorganisms.		1977	26477
mechanism of inhibition of immunization with irradiated tumour cells by a large dose of corynebacterium parvum.		1977	18742
immunotherapy of human cancer.		1977	65906
immunomodulation of host resistance to experimental viral infections in mice: effects of corynebacterium acnes, corynebacterium parvum, and bacille calmette-guérin.	resistance to a representative group of experimental virual infections in mice was significantly enhanced by nonspecific modulation of host defense mechanisms. corynebacterium acnes, corynebacterium parvum, and bacille calmette-guérin were effective in enhancing host resistance. animals treated seven to 10 days before inoculation of virus were protected against a lethal infection with herpesvirus hominis type 2, encephalomyocarditis virus, murine cytomegalovirus, or semliki forest virus. the pro ...	1977	192811
immunomodulator-induced resistance against herpes simplex virus.		1977	193122
[effect of corynebacterium parvum on the immune response in guinea pigs. ii. passive transfer of enhanced anamnestic response and delayed hypersensitivity observed after treatment with corynebacterium parvum].	after intradermal immunization with a mixture of corynebacterium parvum (c. parvum) and ovalbumin guinea pigs show a markedly increased anamnestic response to an intradermal booster of ovalbumin as compared to controls treated with ovalbumin only. at the same time a reaction of delayed type hypersensitivity is observed in the treated animals, but not in controls. the enhanced anamnestic response as well as the posivitive skin reaction were transferred to strain 2 histocompatible guinea pigs by p ...	1977	148949
[effect of corynebacterium parvum on the immune response in guinea pigs. i. mode of enhancement of the anamnestic response and development of delayted hypersensitivity after treatment with corynebacterium parvum].	the effect of corynebacterium parvum (c. parvuum) on the immune response of the guinea pig to ovalbumin varies with the protocol of immunization. the marked effect of c. parvum on the anamnestic response in the rabbit has been confirmed in the guinea pig when immunization is carried out intradermally with a mixture of c. parvum and ovalbumin. when c. parvum is given intravenously or subcutaneously or intradermally but separately from the antigen, this effect is not observed. whatever the route o ...	1977	148948
[blastogenic response in vitro of lymphocyte acne vulgaris].	32 patients with different degrees of acne and 10 healthy controls were studied. on every one of them the test for lymphocytic transformation was performed looking for the range of blastogenic response, using pha and ca. the positive findings with ca related to those obtained in normal subject would support the hypotesis that the cellular immunity as a response to ca antigens would be different in each patient according to the host local conditions.	1977	147371
a reevaluation of fatty acids as inflammatory agents in acne.	the currently widely held theory that intrafollicular free fatty acids (fa) are the primary agents instigating inflammatory changes in acne is based on circumstantial evidence. there is no direct evidence that fa in physiologic concentrations are inflammatory. in the present study the quantities of fa present in isolated pilosebaceous ducts and in isolated comedones were analyzed. using these values, the effect of fa on intracutaneous injection into human skin was investigated. the range of fa i ...	1977	137937
predominant cultivable microbiota in periodontosis.		1977	138729
acne fulminans: investigation of acute febrile ulcerative acne.	eight cases of acne fulminans (acute febrile ulcerative acne) are compared with 13 previously reported cases. this rare disorder of male teenage patients is characterized by the sudden appearance of highly inflammatory, tender, ulcerative and crusted lesions on the back, chest, and face: it is one of the most scarring acute dermatologic disorders of young patients. at the onset of the disease, all patients showed febrile temperatures and marked leukocytosis; other systemic symptoms occurred with ...	1977	139850
an acne-free naevus.	investigation of rare disorders may sometimes help in the understanding of common problems. we describe a patient with an unusual and previously unreported acne-free naevus occurring in an area severely affected by acne. investigation revealed smaller sebaceous glands, a reduced sebum excretion rate, decreased number of corynebacterium acnes in the pilosebaceous ducts and a reduced conversion of testosterone to 5 alphadihydrotestosterone in the areas which were free of acne compared with acne-be ...	1977	139913
the inability of a bacterial lipase inhibitor to control acne vulgaris.		1977	142119
[therapy of acne vulgaris using panoxyl].		1977	143138
an in vivo evaluation of the inflammatory effect of purified comedonal components in human skin.		1977	143497
lymphocyte transformation in subjects with nodulo cystic acne.	patients with severe nodulo-cystic acne are known to have elevated serum antibody levels and increased immediate hypersensitivity reactions to propionibacterium acnes. this organism is the predominant bacterium in normal pilosebaceous follicles of human skin, and can be consistently isolated from pustular lesions in acne. previously it had been observed that delayed cutaneous hypersensitivity reactions to p. acnes were negative in patients with acne. the present study investigated the proliferat ...	1977	143951
acne vulgaris: recent advances in pathogenesis and treatment.	hormonal factors, particularly androgens, appear to be important in the pathogenesis of acne vulgaris. the sebaceous glands in acne are more sensitive to normal blood levels of androgens, and are stimulated to produce more sebum. corynebacterium acnes in the sebaceous follicles act on triglycerides in the sebum to form free fatty acids which might alter the process of keratinization in the follicular canal. a microcomedo is formed which can progress to the clinical lesions of acne. sebum and its ...	1977	144774
[strains of propionibacterium acnes isolated from acne vulgaris (author's transl)].		1977	146146
[in vitro blastogenic response of lymphocytes in acne vulgaris (ii) fusing as mitogens isolated from propionibacterium acnes].		1977	153993
[the nitro-blue-tetrazolium test in acne vulgaris (9-12-77)].	41 patients with different av stages were studied with the quantitative nat test. in those cases where there was an inflammatory process (stages iii and iv) it was positive, while in was negative. the authors consider the relation between this test and the positive lymphoblastic transformation test to pa, which makes evident a coordinate action of the immune specific system and the granulocytic one. this facts show that av at the inflammatory stage is an immunologic systemic process and not only ...	1977	152829
mechanism of action of c. parvum on a solid, subcutaneous mouse tumour.	the effects of i.v. c. parvum on the growth of a.s.c. inoculum of the lewis lung carcinoma were studied in normal c57 b1 mice, and in those in which separate components of the immune response were impaired. c. parvum given either at the same time as tumour inoculation or when the carcinoma was 1 cm in diameter, and fully vascularised, reduced tumour growth. macrophages were impaired by silica (si), cortisone acetate (ca) or trypan blue (tb), and t cells by thymectomy and sublethal irradiation (t ...	1977	204533
immunological mechanisms in metastatic spread and the antimetastatic effects of c. parvum.	the effects of the host's immune response on metastatic spread was investigated by observing the numbers of pulmonary metastases that developed from an s.c. implant of the lewis lung carcinoma in c57bl mice in which different cell populations had been suppressed. macrophage function was impaired by treatment with silica (si), cortisone acetate (ca), or trypan blue (tb). t-cell function was depressed by adult thymectomy and sublethal irradiation, or by treatment with antilymphocyte serum (als). m ...	1977	193547
abrogation of antitumor effects of corynebacterium parvum and bcg by antimacrophage agents: brief communication.	the consistently demonstrable antitumor effect of corynebacterium parvum and bcg against a 7,12-dimethylbenz[a]anthracene-induced rat fibrosarcoma, growing either as a localized subcutaneous tumor or in ascites form, was abrogated by treatment of rats with antimacrophage agents such as silica or carrageenan.	1977	200763
enzymatic and hemolytic properties of propionibacterium acnes and related bacteria.	the production of chondroitin sulfatase, hyaluronidase, deoxyribonuclease, gelatinase, phosphatase, lecithinase, and hemolysins was examined in 95 strains of propionibacterium acnes and four related species of anaerobic, respectively, microaerophilic coryneform bacteria (p. avidum, p. lymphophilum, p. granulosum, and corynebacterium minutissimum). all enzymes could be demonstrated in at least one representative of the species tested. those propionibacterium species most frequently found in acne ...	1977	201661
possible involvement of natural killer cells in bone marrow graft rejection.	in the present study comparison between natural killer (nk) cells and cells responsible for rejection of bone marrow grafts was made. both cell populations were found to be inhibited by cyclophosphamide, silica, carrageenan, and c. parvum. the reactivity of both cell populations occurred late in life and was not expressed in infant mice. mice tolerant to bone marrow grafts and, therefore, accepting parental marrow transplants showed also decreased nk cell reactivities. these common features betw ...	1977	203349
protection against herpes simplex virus infection in mice by corynebacterium parvum.	corynebacterium parvum administered in mice prior to herpes simplex virus (hsv) infection significantly protected them against lethal encephalitis. this was seen both with a mouse strain highly susceptible to hsv and with one relatively resistant to hsv. mice immunosuppressed by cyclophosphamide and showing an increased mortality after hsv infection were also protected by c. parvum pretreatment. however, c. parvum given simultaneously with or after hsv infection did not exert a therapeutic effec ...	1977	194841
antibodies to bacterial and tumor-derived antigens in sera from normal guinea pigs.	antibodies that react with radiolabeled antigens derived from guinea pig line-10 tumor cells and mycobacterium bovis (bcg) were detected in sera from normal tumor-free strain-2 guinea pigs (ngps). binding by ngps to the two antigens was inhibited by extracts of either line-10 cells or bcg. binding by ngps to the line-10 antigen was inhibited by a number of other bacterial extracts. ngps was tested after absorption with a variety of cells including line-10, line-1, normal guinea pig spleen, norma ...	1977	197169
treatment of an intracerebral rat brain tumor with corynebacterium parvum and radiation.	rats bearing intracranial brain tumors were treated with single ip injections of the killed corynebacterium parvum, a single dose of x-rays, or a combination of both treatments. animals given injections of 2.6 mg c. parvum 12 days after implantation of the tumor had a median survival time (mst) of 50 days compared with an mst of 44 days for an untreated group. these animals given c. parvum had a 33% increased life-span (ils) that was significant at the p=0.05 level. although the mst of animals t ...	1977	206836
immunotherapy of cancer.		1977	301988
[is immunotherapy useful in bronchial carcinoma?].		1977	300502
the adjuvant effect of corynebacterium parvum: t-cell dependence of macrophage activation.	splenic and peritoneal macrophages from mice treated with corynebacterium parvum enhanced the antibody response in vitro of normal nonadherent spleen cells to srbc, but not to dnp-pol. this enhancement was dependent on the dose and time of administration of c. parvum and could be abrogated by pretreatment with carrageenan. macrophages from t-cell-depleted mice failed to enhance the response, but this ability was restored if the mice had been reconstituted with purified t lymphocytes. macrophages ...	1977	299769
effect of corynebacterium parvum on tumor growth in normal and athymic (nude) mice.	the effect of systemic or local injection of corynebacterium parvum at the tumor site on the growth of various murine tumors was studied in intact and congenitally athymic balb/c mice. systemic injection of c. parvum usually had a marked antitumor effect in both types of mouse. two lymphomas, which regressed spontaneously in untreated intact mice but not in athymic mice, grew progressively in intact mice given systemic c. parvum, though their growth was inhibited in similarly treated athymic mic ...	1977	299893
in vitro antitumor effect of lymphoid cells from corynebacterium parvum-treated mice: effect of route of c. parvum administration.	corynebacterium parvum administration in cba mice resulted in the stimulation in the peritoneal exudate and other lymphoid organs of cells which nonspecifically inhibited the tumor growth in vitro. the distribution of the antitumor activity in different organs was dependent on the route of c. parvum injection. both ip and iv treatments stimulated antitumor activity in the peritoneal exudate, whereas the sc route was ineffective. only iv treatment stimulated the antitumor activity in the blood, ...	1977	300113
effect of corynebacterium parvum on colony-stimulating factor and granulocyte-macrophage colony formation.	because corynebacterium parvum has tumor-inhibitory properties and stimulates granulocyte-macrophage production, it may have clinical value in combination with chemotherapy. the leukopoietic effect of killed suspensions of c. parvum was studied in mice using the technique of in vitro clonal culture of hematopoietic cells. after c. parvum injection, there was a prompt, sustained elevation of serum colony-stimulating factor followed by an increase in granulocyte-macrophage precursor cells in the s ...	1977	300651
immunological properties of propionibacterium acnes. i. potentiation and suppression on antibody response to sheep and hamster erythrocytes in mice.	adjuvant activity of phenol-treated cells of propionibacterium acnes c-7 in antibody response was investigated in icr mice. simultaneous administration (day 0) of p. acnes (i.p.) and sheep red blood cells (srbc) (i.v.) enhanced the formation of direct plaque-forming cells (pfc) on days 2, and the formation of indirect pfc response on day 7 and thereafter. conversely, pretreatment from 11 to 14 days before antigen injection suppressed markedly the antibody response. the potentiation and the suppr ...	1977	323645
immunotherapy of cancer.	clinical studies have indicated a close relationship between immunological competency and the growth of human cancer. studies in animal systems have indicated that immunological mechanisms are important in host-tumor existence. a number of agents are in the process of being evaluated for their immunotherapeutic potential in patients with cancer. these include levamisole, bacille calmette guérin (bcg) and corynebacterium parvum. while the precise role of these agents in the treatment of human mal ...	1977	322390
effects of corynebacterium parvum on granulocyte/macrophage production and toxicity of chemotherapy.		1977	305373
a role for t lymphocytes in the antitumour action of systemic c. parvum.	the frequency of tumours arising from s.c. injection of a syngeneic chemically-induced fibrosarcoma (fsa) was not influenced by systemic administration of c. parvum (day + 3) except when doses less than the td50 were injected. then the number of takes was increased. the tumour normally grows progressively however regression was frequent in intact mice treated with c. parvum. tumour regression did not occur in t cell-depleted mice treated in the same way. splenic t cell-enriched populations of ce ...	1977	305374
possible mechanisms in the anti-tumour activity of c. parvum.	normal murine peritoneal macrophages exhibited anti-tumour cytotoxicity following simultaneous incubation with c. parvum and lymphoid cells from c. parvum-treated mice. both t- and b-lymphocytes appear to be involved in this macrophage activation which is mediated by a soluble factor(s) released by immune lymphoid cells in response to the specific immunising strain of c. parvum. cells capable of macrophage activation do not appear until 6 days following systemic c. parvum administration despite ...	1977	305375
mechanism of corynebacterium parvum anti-tumour activity. ii. protective effect in t-cell-deprived mice.	the natural resistance to syngeneic mammary carcinoma was reduced by thymectomy alone in adult c3h mice or in mice thymectomized, lethally irradiated and restored with bone-marrow cells (tx rb). the protective effect of c. parvum was not modified by adult thymectomy but it was reduced in tx rb mice. the injection of thymic cells to tx rb mice or the elimination of t cell precursors in bone-marrow cells injected in tx rb mice did not increase the protective effect of c. parvum. these results were ...	1977	334678
[growth of non-sporing anaerobes in an oxygen-free blood culture system (author's transl)].	the efficacy of the commercially available vacutainer blood culture system to support the growth of non-sporing anaerobes was compared with two laboratory-prepared blood culture media (supplemented thioglycollate medium and brain heart infusion). the media were inoculated with 10, 100 and 1000 organisms of the species tested, and the number of colony-forming units was determined at intervals of 8-10 hrs. analogous experiments were performed with batches of the media to which 10% vol/vol of human ...	1977	325956
plasmodium yoelii and plasmodium vinckei: the effects of nonspecific immunostimulation on murine malaria.		1977	330190
a comparison of pyrogenicity and related properties seen in a suspension of corynebacterium parvum and a gramnegative organism.	when the pyrogenic properties of c. parvum and a gramnegative organism, s. typhimurium, were compared it was found that the onset of the pyrogenic response to c. parvum was delayed relative to that of s. typhimurium and that secondary responses rarely occurred. in further experiments the interaction of c. parvum and s. typhimurium was studied. although synergism was not demonstrated, the kinetics of the response to mixtures of the two vaccines was anomalous while pre-treatment of rabbits with c. ...	1977	320069
tumor immunology and immunotherapy.	tumor cells contain a variety of antigens, including tumor associated antigens. the tumor associated antigens can be clinically useful as markers for detection of cancer and some may also mediate host resistance against tumor growth. much emphasis has been placed on the detection of circulating tumor associated markers, with radioimmunoassays for carcinoembryonic antigen (cea) being extensively utilized. at present, cea does not appear to be promising for initial detection of cancer, but may fin ...	1977	321899
corynebacterium parvum as the priming agent in the production of tumor necrosis factor in the mouse.		1977	333124
[porphyrinsynthesis by propionibacterium acnes (author's transl)].	strains of p.a. were isolated from seborrheic filaments from 11 persons and investigated according to their production of porphyrins. after growing the organisms during a 5 resp. 10 days cultivation period on solid as well as in liquid culture medium the quantity and quality of the bacterial porphyrins were determined. there existed intense variations in quantity not only when the special strains were compared with each other but also when the same strains were treated with different preparation ...	1977	334087