Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| recombinant vaccinia viruses expressing the f, g or n, but not the m2, protein of bovine respiratory syncytial virus (brsv) induce resistance to brsv challenge in the calf and protect against the development of pneumonic lesions. | the immunogenicity and protective efficacy of recombinant vaccinia viruses (rvv) encoding the f, g, n or m2 (22k) proteins of bovine respiratory syncytial virus (brsv) were evaluated in calves, the natural host for brsv. calves were vaccinated either by scarification or intratracheally with rvv and challenged 6 to 7 weeks later with brsv. although replication of rvv expressing the f protein in the respiratory tract was limited after intratracheal vaccination, the levels of serum and pulmonary an ... | 1997 | 9400970 |
| secretory igm and iga antibodies to respiratory syncytial virus in nasopharyngeal aspirates: a diagnostic supplement to antigen detection. | rsv-shedding during an rsv-infection declines dramatically after the first week of infection. it could be of interest to be able to diagnose rsv-infection for a longer period of time by detection of specific rsv-igm and rsv-iga in nasopharyngeal aspirates (npa) in order to minimize unnecessary antibiotics. | 1997 | 9406652 |
| improved detection of respiratory syncytial virus in nasal aspirates by seminested rt-pcr. | a seminested rt-pcr for amplification of respiratory syncytial virus (rsv)-rna in nasal aspirates has been developed and used to test nasopharyngeal aspirates (npas) from 132 infants hospitalized with acute respiratory tract infections during winter epidemics. the results were compared with those obtained by virus isolation in tissue culture and antigen detection with an enzyme-linked immunosorbent assay (ag-elisa). rsv-rna was detected by seminested rt-pcr in 57 of the 59 samples that were posi ... | 1997 | 9407385 |
| update: respiratory syncytial virus activity -- united states, 1997-98 season. | respiratory syncytial virus (rsv), a common cause of winter outbreaks of acute respiratory disease, results in an estimated 90,000 hospitalizations and 4500 deaths each year from lower respiratory tract disease among infants and young children in the united states. outbreaks occur annually throughout the country. rsv activity in the united states is monitored by the national respiratory and enteric virus surveillance system (nrevss), a voluntary, laboratory-based system. this report summarizes t ... | 1997 | 9408044 |
| transfection of human endothelial cells. | the introduction of recombinant genes into endothelial cells provides a method to study specific gene products and their effect on cell function. in addition, endothelial cells can be used for implantation into vessels or prosthetic vascular grafts. because transfection efficiencies in human endothelial cells have been low, it is important to develop improved gene transfer techniques. therefore, several transfection methods were optimized and transfection efficiencies were determined. | 1997 | 9415297 |
| analysis of tissue-specific gene delivery by recombinant adenoviruses containing cardiac-specific promoters. | to approach heart muscle diseases by gene transfer, an adenoviral vector system was intended to be established suitable for gene expression in ventricular and/or atrial myocardium. | 1997 | 9415302 |
| pantropic retroviral vector integration, expression, and germline transmission in medaka (oryzias latipes). | pantropic retroviral vectors were used to introduce transgenes into japanese medaka (oryzias latipes). these vectors contain the long terminal repeat (ltr) sequence of moloney murine leukemia virus (mo-mlv) and a reporter gene (neo or lacz) regulated by the ltr sequence of rous sarcoma virus (rsv). because these pseudotyped retroviral vectors contain the vesicular stomatitis virus envelope glycoprotein (vsv-g), they have an extremely broad host cell range and can infect many no mammalian species ... | 1997 | 9418287 |
| [relationship between human parvovirus b19 infection and spontaneous abortion]. | to determine whether there is a relationship between parvovirus b19 infection and spontaneous abortion. | 1997 | 9639755 |
| local variability in respiratory syncytial virus disease severity. | respiratory syncytial virus (rsv) lower respiratory tract infections are considered to be a serious disease in centres such as the sophia children's hospital (rotterdam, the netherlands), but as more benign infections in others such as the geneva children's hospital (switzerland). to assess the clinical severity of rsv infections at the two sites, 151 infants primarily admitted with a virologically confirmed rsv infection were studied prospectively (1994-5) and retrospectively (1993-4) (55 infan ... | 1997 | 9487963 |
| [application of the polymerase chain reaction for detecting respiratory syncytial virus]. | the polymerase chain reaction (pcr) was developed in order to identify the respiratory syncytial virus by using the reference strain. the high sensitivity and specificity obtained show the pcr utility for detecting the rsv genoma and its application on the diagnosis. | 1997 | 9685955 |
| [animal experiment on gene therapy of ovarian cancer by adenovirus-mediated thymidine kinase gene transduction and ganciclovir administration in vivo]. | the efficacy and toxicity of adenovirus-mediated transduction of herpes simplex virus thymidine kinase gene started by rous sarcoma virus (adv/rsv-tk) followed by administration of ganciclovir (gcv) were studied in vivo. | 1997 | 9772431 |
| respiratory syncytial virus genotypes and disease severity among children in hospital. | to determine the spectrum of n and g genotypes of respiratory syncytial virus (rsv) causing respiratory tract infection and whether particular genotypes are associated with severity of infection. | 1997 | 9496185 |
| [effects of selenium supplement on acute lower respiratory tract infection caused by respiratory syncytial virus]. | an intervention study was conducted in 75 young children under one year hospitalized with pneumonia or bronchiolitis caused by respiratory syncytial virus (rsv) to evaluate therapeutic effectiveness of selenium (se) supplement on acute respiratory lower tract infection caused by rsv with randomly controlled and double-masked method. trial subjects were divided into two groups, one with 37 children in routine treatment and the other with 38 children in routine treatment plus se supplement. the co ... | 1997 | 9863072 |
| reduction of respiratory syncytial virus hospitalization among premature infants and infants with bronchopulmonary dysplasia using respiratory syncytial virus immune globulin prophylaxis. the prevent study group. | to determine the safety and efficacy of monthly prophylaxis with respiratory syncytial virus immune globulin, intravenous (rsv-igiv) for reduction of the incidence of rsv-associated hospitalization. | 1997 | 8989345 |
| increase in cd23+ b cells in infants with bronchiolitis is accompanied by appearance of ige and igg4 antibodies specific for respiratory syncytial virus. | infection with respiratory syncytial virus (rsv) may induce asthma-like symptoms and rsv-specific ige in infected infants as a result of th2-like response to rsv. the effect of rsv infection on the expression of b cell antigens cd21 and cd23, putative participants in th2 responses, was investigated. samples from bronchiolitic infants (n = 19) were tested by three-color immunofluorescence flow cytometry during the acute phase of infection and 4-6 weeks later. in 6 of 10 rsv-positive infants, the ... | 1997 | 8985193 |
| virus-specific memory and effector t lymphocytes exhibit different cytokine responses to antigens during experimental murine respiratory syncytial virus infection. | mice sensitized to the g (attachment) or f (fusion) glycoproteins of respiratory syncytial virus (rsv) expressed different patterns of cytokine production and lung pathology when challenged by intranasal infection with rsv. five days after challenge, mice sensitized to g glycoprotein produced high levels of interleukin-4 (il-4) and il-5 in the lungs and spleens and developed extensive pulmonary eosinophilia, while mice sensitized to f glycoprotein produced il-2 and developed a mononuclear cell i ... | 1997 | 8985399 |
| respiratory syncytial virus immune globulin intravenous. | to review the clinical data detailing the use of respiratory syncytial virus immune globulin intravenous (rsv-igiv) in infants and children. data sources; a medline search (1990-1996) was used to identify all publications that dealt with rsv-igiv clinical trials, pharmacology, and pharmacokinetics in infants and children. bibliographies of articles were also used. | 1997 | 8997472 |
| rhinovirus infection associated with serious lower respiratory illness in patients with bronchopulmonary dysplasia. | to determine the characteristics of rhinovirus infection in patients with bronchopulmonary dysplasia. | 1997 | 9002100 |
| detection of antibodies to respiratory syncytial virus attachment and nucleocapsid proteins with recombinant baculovirus-expressed antigens. | the ability to measure antibodies against individual respiratory syncytial virus (rsv) proteins is important in the analysis of immune responses to rsv. we expressed the nucleocapsid (n) protein and the group a and b rsv attachment (g) proteins from recombinant baculoviruses. the three recombinant rsv proteins were used individually in an enzyme-linked immunosorbent assay (elisa; bac-elisa for results from assays of all three proteins). the bac-elisa results were compared to the results obtained ... | 1997 | 9003595 |
| physiological effects of adenoviral gene transfer of sarcoplasmic reticulum calcium atpase in isolated rat myocytes. | in myocardial cells, relaxation is governed primarily by the sarcoplasmic reticulum (sr) ca(2+)-atpase transporting enzyme, which regulates ca2+ sequestration into the sr. human and experimental cardiomyopathies are associated with reduced sr ca(2+)-atpase activity. | 1997 | 9008460 |
| guidelines for prevention of nosocomial pneumonia. centers for disease control and prevention. | this document updates and replaces cdc's previously published "guideline for prevention of nosocomial pneumonia" (infect control 1982;3:327-33, respir care 1983;28:221-32, and am j infect control 1983;11:230-44). this revised guideline is designed to reduce the incidence of nosocomial pneumonia and is intended for use by personnel who are responsible for surveillance and control of infections in acute-care hospitals; the information may not be applicable in long-term-care facilities because of t ... | 1997 | 9036304 |
| adenovirus-mediated suicide gene therapy for experimental bladder cancer. | to determine the feasibility, safety, and efficacy of suicide gene therapy using adenoviral-mediated herpes simplex virus thymidine kinase gene (hsv-tk) and the prodrug ganciclovir (gcv) in a murine model of human transitional cell carcinoma. | 1997 | 9037277 |
| inhibition of respiratory syncytial virus replication by antisense oligodeoxyribonucleotides. | oligodeoxyribonucleotides targeted against respiratory syncytial virus (rsv) genomic rna inhibited rsv replication in cell culture by an apparent antisense mechanism. hep-2 cells were infected with rsv strain a2 and incubated in the presence of oligonucleotides. virus replication was measured by enzyme-linked immunosorbent assay (elisa), virus yield assay, or production of specific rsv mrnas. using elisa, 50% effective concentration (ec50) values were about 0.5-1 microm for an antisense oligonuc ... | 1997 | 9037376 |
| hypotension in transgenic mice overexpressing human bradykinin b2 receptor. | bradykinin binds to its receptor at target organs and exerts a wide spectrum of biological activities including vasodilation, smooth muscle contraction and relaxation, pain, and inflammation. to gain a better insight into the physiological function of this potent vasoactive peptide, we created transgenic mice that harbor the human bradykinin b2 receptor transgene under the control of the rous sarcoma virus 3'-ltr promoter (rsv-chbkr). expression of hbkr in these transgenic mice was identified in ... | 1997 | 9039147 |
| respiratory syncytial virus (rsv) immune globulin intravenous therapy for rsv lower respiratory tract infection in infants and young children at high risk for severe rsv infections: respiratory syncytial virus immune globulin study group. | to evaluate the efficacy of high-titer intravenous respiratory syncytial virus immune globulin (rsvig) in the treatment of children at high risk for severe rsv infection who were hospitalized with proven rsv. | 1997 | 9041304 |
| respiratory syncytial virus induces selective production of the chemokine rantes by upper airway epithelial cells. | the presence of histamine and eosinophil cationic protein in nasopharyngeal secretions of infants with respiratory syncytial virus (rsv)-induced bronchiolitis implies the activation of basophil and eosinophil leukocytes, but the specific mechanism of their recruitment has not been elucidated. chemokines are potent and selective leukocyte chemotactic molecules that are also expressed by airway epithelial cells. therefore, the pattern of chemokines produced in response to rsv infection was investi ... | 1997 | 9041319 |
| extracorporeal life support for the treatment of viral pneumonia: collective experience from the elso registry. extracorporeal life support organization. | viral pneumonia is the most common indication for pediatric extracorporeal life support (ecls). despite this fact, no previous studies have directly stratified patient outcome according to viral etiology. | 1997 | 9044128 |
| adenovirus-mediated delivery of human kallistatin gene reduces blood pressure of spontaneously hypertensive rats. | human kallistatin, or human tissue kallikrein-binding protein (hkbp), is a serine proteinase inhibitor (serpin). transgenic mice overexpressing rat kallikrein-binding protein are hypotensive. to elucidate therapeutic potentials of kallistatin in hypertension, the human kallistatin gene in an adenoviral vector was directly introduced into spontaneously hypertensive rats (shr) through portal vein injection. the kallistatin cdna construct (rsv-chkbp) under the promoter control of rous sarcoma virus ... | 1997 | 9048201 |
| targeting rna decay with 2',5' oligoadenylate-antisense in respiratory syncytial virus-infected cells. | treatment of human cells with 2',5' oligoadenylate covalently linked to antisense (2-5a-antisense) results in the selective cleavage of targeted rna species by 2-5a-dependent rnase l. here we show that 2-5a-antisense containing stabilizing modifications at both termini are effective in suppressing the replication of respiratory syncytial virus (rsv) in human tracheal epithelial cells. the affinity of 2-5a-antisense for different regions in the rsv m2 and l mrnas was predicted from a computer-gen ... | 1997 | 9050883 |
| cell lines containing and expressing the human herpesvirus 6a ts gene are protected from both h-ras and bpv-1 transformation. | human herpesvirus 6a (hhv-6a) strain u1102 was previously shown to contain a 1473 bp transformation suppressor gene (ts) (araujo et al., 1995). ts inhibited transformation of nih3t3 cells by h-ras and transcription of the h-ras and human immunodeficiency type 1 (hiv-1) promoters in transient transfection experiments. in the current study, stable nih3t3 cell lines expressing ts protein were established by transfection with prc-ts containing the ts gene under the control of the rous sarcoma virus ... | 1997 | 9050993 |
| splicing efficiency of human immunodeficiency virus type 1 tat rna is determined by both a suboptimal 3' splice site and a 10 nucleotide exon splicing silencer element located within tat exon 2. | we have previously demonstrated that an exon splicing silencer (ess) is present within human immunodeficiency virus type 1 (hiv-1)tat exon 2. this 20 nucleotide (nt) rna element acts selectively to inhibit splicing at the upstream 3'splice site (3'ss #3) flanking this exon. in this report, we have used in vitro splicing of mutated rna substrates to determine the sequences necessary and sufficient for the activity of the ess. the activity of the ess within tat exon 2 maps to a 10 nt core sequence ... | 1997 | 9016638 |
| antigenic and molecular analyses of the variability of bovine respiratory syncytial virus g glycoprotein. | antigenic variation among eight bovine respiratory syncytial virus (brsv) isolates was determined using monoclonal antibodies (mabs) specific for the attachment (g) protein. two major (and one intermediate) subgroups were identified, as well as one strain that did not fit any pattern. the subgroups could also be differentiated on the basis of the mr of the f protein cleavage product, f2. the nucleotide sequence of the g gene of seven of the brsv strains was determined and compared with published ... | 1997 | 9018058 |
| androgen-dependent cell cycle arrest and apoptotic death in pc-3 prostatic cell cultures expressing a full-length human androgen receptor. | to assess the function of androgen receptor in androgen-independent prostate cancer cells, human pc-3 prostate carcinoma cells, which lack androgen receptor (ar) expression, were transfected with a full length human ar cdna sequence inserted into an episomal expression vector system. several clonal lines of transfected cells expressing varying levels of a 110 kda ar, as determined by immunoblotting and ligand binding assay, were isolated. the expressed ectopic receptors displayed nuclear binding ... | 1997 | 9027364 |
| analysis of recombinant adeno-associated virus packaging and requirements for rep and cap gene products. | adeno-associated virus (aav) is a human parvovirus currently being developed as a vector for gene therapy applications. because the gene transfer vector commonly retains only the aav terminal repeats, propagation of recombinant aav (raav) requires that the viral replication (rep) and capsid (cap) proteins be supplied in trans. in an effort to optimize the production of these vectors, a panel of helper plasmids was constructed to determine if expression of the rep and/or cap genes is a limiting f ... | 1997 | 9032320 |
| altered rous sarcoma virus gag polyprotein processing and its effects on particle formation. | proteolytic processing of the rous sarcoma virus (rsv) gag precursor was altered in vivo through the introduction of amino acid substitutions into either the polyprotein cleavage junctions or the pr coding sequence. single amino acid substitutions (v(p2)s and p(p4)g), which are predicted from in vitro peptide substrate cleavage data to decrease the rate of release of pr from the gag polyprotein, were placed in the nc portion of the nc-pr junction. these substitutions do not affect the efficiency ... | 1997 | 9032340 |
| persistence of respiratory syncytial virus (rsv) infection and development of rsv-specific igg1 response in a guinea-pig model of acute bronchiolitis. | acute respiratory syncytial virus (rsv) bronchiolitis in children can result in sequelae of recurrent wheezing and asthma and production of rsv-specific immunoglobulin e (ige), but the pathogenesis of these sequeleae is poorly understood. guinea-pigs experimentally inoculated with human rsv show histological evidence of acute bronchiolitis and chronic persistence of viral antigens and genome in the lungs; whether this persistence is due to infectious replicating virus, and whether infected anima ... | 1997 | 9032486 |
| persistence of airway hyperresponsiveness and viral antigen following respiratory syncytial virus bronchiolitis in young guinea-pigs. | respiratory syncytial virus (rsv) bronchiolitis in infancy is known to be followed by chronic respiratory symptoms and airway hyperresponsiveness in a subgroup of patients. to further investigate the pathogenesis of rsv-induced chronic airway pathology, we infected young guinea-pigs at 4 weeks of age with rsv applied as an aerosol (n=30), and control guinea-pigs with virus-free culture medium (n=24). infection was confirmed by positive antibody titre to rsv after 6 weeks, and by typical patholog ... | 1997 | 9072998 |
| respiratory syncytial virus triggers synthesis of il-6 in balb/c mouse alveolar macrophages in the absence of virus replication. | cytokines produced by alveolar macrophages are likely involved in the regulation of the immune response arising from respiratory syncytial virus (rsv) infection. both infectious and uv-inactivated rsv were effective in inducing balb/c mouse alveolar macrophages to synthesize increased levels of il-6 mrna and secreted il-6 protein. no increase in il-1beta (either mrna or secreted protein) was observed. the augmented production of il-6 was activated by purified virus and was reduced by pretreating ... | 1997 | 9073384 |
| follow-up of children with respiratory syncytial virus bronchiolitis in 1986 and 1987: potential effect of ribavirin on long term pulmonary function. the bronchiolitis study group. | hospitalization for respiratory syncytial virus (rsv) bronchiolitis is considered a risk factor for reactive airway disease and/or abnormal pulmonary function tests (pfts) later in childhood. this study attempted to assess this observation with newer pfts and to determine whether ribavirin therapy of initial rsv infection may affect the long term outcome. | 1997 | 9076814 |
| standardization of enzyme-linked immunosorbent assays (elisas) for quantitative estimation of antibodies specific for infectious bovine rhinotracheitis virus, respiratory syncytial virus, parainfluenza-3 virus, and bovine viral diarrhea virus. | commercial enzyme-linked immunosorbent assays (elisas) for detection of serum antibodies to bovine viral diarrhea virus (bvdv), parainfluenza-3 virus (pi3v), respiratory syncytial virus (rsv), and infectious bovine rhinotracheitis virus (ibrv) were standardized to give a quantitative result when testing was performed at a single optimum dilution. for each test, serum samples were titrated and their end point titers calculated by an algebraic method directly from a plot of each titration series a ... | 1997 | 9087921 |
| respiratory syncytial virus bronchiolitis. | respiratory syncytial virus (rsv) bronchiolitis is associated with the clinical signs and symptoms of small airway obstruction. a major public health problem throughout the world, this condition is responsible for significant morbidity and mortality. management is primarily preventive, through strict hand washing, avoidance of exposure during the respiratory illness season and intravenously administered prophylactic anti-rsv immune globulin, especially in selected small infants with underlying c ... | 1997 | 9092277 |
| respiratory syncytial virus immune globulin intravenous: indications for use. american academy of pediatrics committee on infectious diseases, committee on fetus and newborn. | respiratory syncytial virus immune globulin intravenous (rsv-igiv) has been approved by the food and drug administration for use in the prevention of severe rsv infections in infants and children younger than 24 months with bronchopulmonary dysplasia or a history of premature birth (< or = 35 weeks of gestation). rsv-igiv administered monthly during the rsv season resulted in a 41% to 65% reduction in hospitalization rates in two clinical trials; however, rsv-igiv is costly, and intravenous admi ... | 1997 | 9093323 |
| analysis of linear epitopes recognised by the primary human antibody response to a variable region of the attachment (g) protein of respiratory syncytial virus. | the sites of linear epitopes in a variable region of the attachment (g) glycoprotein of respiratory syncytial virus (rsv) that are recognised by the human antibody response were examined. two sets of overlapping 12mer peptides each representing the carboxy-terminal 84 or 85 amino acids of the g protein of two group a isolates of human rsv were synthesised. these peptides were analysed using enzyme-linked immunosorbant assays (elisa) for their reactions with sera obtained from infants with primar ... | 1997 | 9093944 |
| antigenic structure of the central conserved region of protein g of bovine respiratory syncytial virus. | epitopes were resolved at the amino acid level for nine monoclonal antibodies (mabs) directed against the central conserved region of protein g of bovine respiratory syncytial virus (brsv-g). peptide binding studies showed which amino acids in the epitope contributed to antibody binding. the details of the epitopes were compared with the high-resolution structure of a synthetic peptide corresponding to the central conserved region of brsv-g, and this indicated which face of the central conserved ... | 1997 | 9094683 |
| acute respiratory distress syndrome caused by respiratory syncytial virus. | acute respiratory distress syndrome (ards) complicating severe respiratory syncytial virus (rsv) infection has been described in only a few infants. in contrast to the low mortality rates usually associated with rsv infections (< 5%), mortality rates in the range of 40-70% have been reported in pediatric patients with ards. however, studies on patients with ards are usually lumped with respect to causation, and the disease course of rsv-induced ards has not been previously studied. we examined t ... | 1997 | 9094725 |
| twenty years of outpatient respiratory syncytial virus infection: a framework for vaccine efficacy trials. | respiratory syncytial virus (rsv) is the most important viral respiratory pathogen of infancy and childhood. much has been written about inpatients with severe disease. inpatients, however, represent only a minority of rsv-infected children. we studied the characteristics of symptomatic outpatient rsv infection in healthy children to gain a better understanding of rsv disease and to provide a background for the testing of intervention strategies in children without high-risk conditions. | 1997 | 9099764 |
| does ribavirin impact on the hospital course of children with respiratory syncytial virus (rsv) infection? an analysis using the pediatric investigators collaborative network on infections in canada (picnic) rsv database. | to determine the relationship between receipt of aerosolized ribavirin and the hospital course of high-risk infants and children with respiratory syncytial virus (rsv) lower respiratory infection (lri). | 1997 | 9099772 |
| picnic (pediatric investigators collaborative network on infections in canada) study of the role of age and respiratory syncytial virus neutralizing antibody on respiratory syncytial virus illness in patients with underlying heart or lung disease. | to determine the effects of age and respiratory syncytial virus (rsv) antibody status on frequency and severity of rsv infections in children with underlying heart or lung disease. | 1997 | 9099774 |
| inducible high-level expression vector for mammalian cells, pef-lac carrying human elongation factor 1alpha promoter and lac operator. | we have constructed an inducible high-level expression vector, pef-lac. pef-lac has a modified human polypeptide chain elongation factor 1alpha (ef-1alpha) promoter containing three lactose operator sequences. using the cat reporter gene, we characterized the transcriptional activity of pef-lac. in the transient transfection of nih3t3 and baf3 cells, the transcriptional activity of pef-lac was higher than that of the original human elongation factor 1alpha promoter, simian virus 40 (sv40) promot ... | 1997 | 9099894 |
| potent inhibition of respiratory syncytial virus by polyoxometalates of several structural classes. | a series of polyoxometalates (pom) were synthesized and evaluated for anti-respiratory syncytial virus (rsv) activity. pom containing zirconium, tungsten, silicon, platinum, niobium or germanium of a variety of structural types have been evaluated. sixteen of the compounds had very striking anti-rsv activity against a clinical isolate, utah 89, with median effective concentration (ec50) values < or = 3 microm and selective indices > 80 as determined by viral cytopathic inhibition effect, neutral ... | 1997 | 9107383 |
| rsv infection of human airway epithelial cells causes production of the beta-chemokine rantes. | infection of airway epithelial cells with respiratory syncytial virus (rsv) results in the production of a restricted number of cytokines, which may modulate the inflammatory response to infection. to get a better understanding of epithelial cell-mediated inflammatory processes in rsv disease, the aim of the present study was to identify the production of mononuclear cell/eosinophil/mast cell inflammatory chemokines [monocyte chemotactic protein (mcp)-1, mcp-3, macrophage inflammatory protein-1b ... | 1997 | 9124609 |
| expression of mxa protein in blood lymphocytes discriminates between viral and bacterial infections in febrile children. | interferons (ifns), which are induced by viruses, form an essential part of host's defense systems against viral infections. the antiviral actions of ifns are mediated by several ifn-inducible gene products, one of which is mx protein. to evaluate whether mxa protein expression in lymphocytes could function as an indicator of endogenous ifn production in children with acute febrile illness, we analyzed mxa protein levels in peripheral blood lymphocytes by flow cytometry in the acute phase of the ... | 1997 | 9128286 |
| enhanced cytokine production by milk macrophages following infection with respiratory syncytial virus. | paired samples of milk and serum collected 3 days postpartum from 20 women were tested for the presence and level of interleukin (il)-1, il-6, il-12, tumor necrosis factor alpha (tnf-alpha), and interferon-gamma (ifn-gamma) by enzyme immunoassay. the expression of these cytokine mrnas in milk macrophages from eight donors were semiquantitatively analyzed by reverse transcriptase-polymerase chain reaction. the effects of respiratory syncytial virus (rsv) infection on cytokine production were dete ... | 1997 | 9129213 |
| respiratory syncytial virus specific serum antibodies in infants under six months of age: limited serological response upon infection. | the decline of maternal respiratory syncytial virus (rsv) specific serum antibodies was studied in 45 children during the first 6 months of life, using a virus neutralization assay and competition elisas measuring fusion protein and glycoprotein specific antibodies. in all children rsv neutralizing antibodies were demonstrated at birth, with titers ranging from 33 to 1382. the calculated mean half life of these antibodies was 26 days. furthermore, in a group of 38 children with suspected rsv inf ... | 1997 | 9131465 |
| growth factor ligands of tyrosine kinase receptors activate the rous sarcoma virus promoter by a ras- and raf-dependent mechanism. | in pc12 cells, ngf and other ligands of tyrosine kinase receptors increased the activity of the rous sarcoma virus (rsv) promoter. igf-1 stimulated the rsv promoter in sh-sy5y neuroblastoma cells. this promoter was also activated by oncogenic ras and raf in different cell types, and growth factor induction was inhibited by expression of dominant negative forms of ras and raf, showing that its effect is mediated by a ras- and raf-dependent mechanism. therefore, the rsv promoter should not be used ... | 1997 | 9133605 |
| immunological responses to respiratory syncytial virus infection in infancy. | to determine whether there is evidence of immunological responses in infants with respiratory syncytial virus (rsv) bronchiolitis by measuring inflammatory mediators in peripheral blood and, if found, whether these related to the severity of illness. | 1997 | 9135260 |
| severity of respiratory syncytial virus infection is related to virus strain. | the relationship between respiratory syncytial virus (rsv) strain and disease severity was assessed in 265 hospitalized infants over a 3-year period (1988-1991). a severity index of clinical and physiologic parameters was used to grade illness severity. multivariate analysis of 134 infants infected with group a rsv strains and 131 infants infected with group b strains indicated that prematurity, underlying medical conditions, group a rsv infection, and age < or =3 months were independently assoc ... | 1997 | 9086135 |
| immunoprophylaxis of group b respiratory syncytial virus infection in cotton rats. | two antigenic groups of respiratory syncytial virus (rsv) have been identified: a (rsv/a) and b (rsv/b). topical administration of human igg screened for high titers of antibody to rsv/a (rsvig) is protective against rsv/a infection in the cotton rat model. the study attempted to determine if topical rsvig would also be protective against rsv/b. cotton rats were pretreated intranasally with rsvig or with monospecific antiserum obtained from animals previously infected with rsv/a or rsv/b (day 0) ... | 1997 | 9086152 |
| the guinea pig as a model for the study of maternal immunization against respiratory syncytial virus infections in infancy. | maternal immunization might protect infants from severe disease due to respiratory syncytial virus (rsv). guinea pigs are susceptible to infections with rsv and transfer antibodies to their offspring prenatally. pregnant guinea pigs were immunized by infection with rsv and their offspring were challenged intranasally with rsv. pulmonary viral replication was compared among the pups born to immunized mothers (group a) and the pups from nonimmune mothers (group b) in two studies. mean (+/-sd) log1 ... | 1997 | 9086153 |
| phosphoprotein profile analysis of ruminant respiratory syncytial virus isolates. | to determine the apparent molecular weight for 24 ruminant respiratory syncytial viruses (rsv) on the basis of differences in the electrophoretic mobility of the phosphoprotein (p protein). | 1997 | 9140554 |
| subgroup specific protection of mice from respiratory syncytial virus infection with peptides encompassing the amino acid region 174-187 from the g glycoprotein: the role of cysteinyl residues in protection. | we identified subgroup specific protective epitopes represented by the amino acid regions 174-187 and 171-187 of the g glycoproteins from respiratory syncytial virus (rsv), subgroups a and b. mice immunized with coupled synthetic peptides corresponding to either the region 174-187 containing a cys186-->ser substitution or to the native region 171-187 were completely resistant to rsv infection but only to the respective virus. the protective activities of the peptides 174-187 were dependent on th ... | 1997 | 9141214 |
| induction of protective immunity in rodents by vaccination with a prokaryotically expressed recombinant fusion protein containing a respiratory syncytial virus g protein fragment. | a subunit approach to the development of a respiratory syncytial virus (rsv) vaccine was investigated. it involved the production, in escherichia coli, of an rsv (long) g protein fragment (g2na) as a c-terminal fusion partner to an albumin binding region (bb) of streptococcal protein g. g2na incorporated amino acid residues 130-230 and was specifically recognized by murine anti-rsv-a polyclonal serum. in mice, intraperitoneal immunization with bbg2na induced high anti-rsv-a serum elisa titers an ... | 1997 | 9143271 |
| cationic liposome-mediated expression of hiv-regulated luciferase and diphtheria toxin a genes in hela cells infected with or expressing hiv. | hiv-regulated expression of the diphtheria toxin a fragment gene (hiv-dt-a) is a potential gene therapy approach to aids. since cationic liposomes are safe and non-immunogenic for in vivo gene delivery, we examined whether lipofectamine or dmrie reagent could mediate the transfection of hiv-dt-a (ptha43) or the hiv-regulated luciferase gene (pluca43) into hiv-infected or uninfected hela cells. pluca43 was expressed at a 10(3)-fold higher level in hela/lav cells than in uninfected hela cells, whi ... | 1997 | 9150276 |
| t cell source of type 1 cytokines determines illness patterns in respiratory syncytial virus-infected mice. | manipulation of the cytokine microenvironment at the time of vaccination can influence immune responses to remote challenge, providing a strategy to study the molecular pathogenesis of respiratory syncytial virus (rsv) vaccine-enhanced disease in the mouse model. although treatment with antibody against il-4 or recombinant il-12 (ril-12) at the time of formalin-inactivated rsv vaccination induced a similar shift in the pattern of cytokine mrna expression upon live virus challenge, anti-il-4 trea ... | 1997 | 9151790 |
| in vitro assembly of virus-like particles with rous sarcoma virus gag deletion mutants: identification of the p10 domain as a morphological determinant in the formation of spherical particles. | retroviruses are unusual in that expression of a single protein, gag, leads to budding of virus-like particles into the extracellular space. we have developed conditions under which virus-like particles are formed spontaneously in vitro from fragments of rous sarcoma virus (rsv) gag protein purified after expression in escherichia coli. the ca-nc fragment of gag was shown previously to assemble into hollow cylinders (s. campbell and v. m. vogt, j. virol. 69:6487-6497, 1995). we have now extended ... | 1997 | 9151833 |
| treatment of respiratory syncytial virus bronchiolitis: 1995 poll of members of the european society for paediatric infectious diseases. | among the lower respiratory tract infections during infancy requiring hospitalization, respiratory syncytial virus (rsv) bronchiolitis is the most frequent disease entity. nevertheless treatment remains controversial. | 1997 | 9154540 |
| ribavirin therapy in bone marrow transplant recipients with viral respiratory tract infections. | treatment with ribavirin was instituted in 12 allogeneic and one autologous bone marrow transplant (bmt) recipients with proven respiratory syncytial virus (rsv), influenza b virus or parainfluenza virus infections. rsv was diagnosed in six cases, influenza b virus in four and parainfluenza virus in three patients. ribavirin was given orally or intravenously (15-20 mg/kg/day in three divided doses) and in nine cases with the addition of ribavirin inhalations (6 g/day). three patients required ve ... | 1997 | 9156264 |
| chicken yb-2, a y-box protein, is a potent activator of rous sarcoma virus long terminal repeat-driven transcription in avian fibroblasts. | we have previously reported on the cloning and characterization of chk-yb-2, a novel member of the y-box family of proteins, that binds to the sequence 5'-gtaccacc-3' present on the noncoding strand of the rous sarcoma virus (rsv) long terminal repeat (ltr) in a single-strand-specific manner. here, we demonstrate that deletion or mutation of this motif not only eliminates chk-yb-2 binding in vitro but also down-regulates rsv ltr-driven transcription in avian cells. selective abrogation of chk-yb ... | 1997 | 9060644 |
| improved oxygenation after discontinuing neuromuscular blockade. | to evaluate the effects of prolonged neuromuscular blockade (nmb) on oxygenation and duration of mechanical ventilation in children with respiratory failure. | 1997 | 9069009 |
| myogenin expression is necessary for commitment to differentiation and is closely related to src tyrosine kinase activity in quail myoblasts transformed with rous sarcoma virus. | quail myoblasts transformed with a temperature-sensitive mutant of rous sarcoma virus (qm-rsv cells) proliferate at 35.5 degrees c, a permissive temperature for rsv, but differentiate at 41 degrees c, a nonpermissive temperature, with the formation of multinucleated myotubes and the synthesis of muscle-specific proteins. tyrosine kinase activity of the src gene product derived from rsv is closely related to regulation of this temperature-dependent differentiation, and the cells obtain commitment ... | 1997 | 9157009 |
| [bronchiolitis: revision of 153 cases and comparative study of ribavirin treatment]. | we try in this paper to improve the knowledge of the main epidemiological, clinic, evolutive and therapeutic data in cases of children suffering from bronchiolitis in our medium; we analyze particularly the possible usefulness of ribavirin as a causal treatment. | 1997 | 9157802 |
| production of env-deficient rous sarcoma virus (rsv) early after infection. | production of defective virus particles during the early stage of rous sarcoma virus (rsv) infection of chicken embryo fibroblasts (cef) was examined. rsv harvested 2 days post infection (2pi) had 10 to 30 times lower specific infectivity (focus forming units/unit reverse transcriptase activity) than 5pi harvest. virus particles produced on day 2 contained less env proteins than particles harvested on day 5. the amount of other viral proteins was equal in particles harvested on day 2 and day 5. ... | 1997 | 9158953 |
| adjuvants influence the quantitative and qualitative immune response in balb/c mice immunized with respiratory syncytial virus fg subunit vaccine. | the ability of monophosphoryl lipid a (mpl), qs-21 and alum to alter the immunologic response to immunization with respiratory syncytial virus a chimeric fg construct (fg) subunit vaccine was examined in balb/c mice. fg/mpl, fg/alum, and fg/mpl/qs-21 combinations increased non-neutralizing antibody response, while fg/qs-21 did not. fg subunit vaccine with mpl, qs-21, or both had cytokine responses more closely resembling primary infection than fg/alum, with decreased interleukin-4 mrna levels an ... | 1997 | 9160520 |
| restriction pattern variability of respiratory syncytial virus during three consecutive epidemics in denmark. | a pcr-based assay was used to distinguish between respiratory syncytial virus (rsv) group a and b in order to analyze their prevalence in denmark in three consecutive epidemics during the winters of 1992/93, 1993/94 and 1994/95. a total of 96 rsv strains isolated from hospitalized children were examined, showing alternation of group prevalence. furthermore, the genetic variability of the rsv isolates was illustrated by restriction enzyme analysis of pcr products originating from a part of the f ... | 1997 | 9164473 |
| gene transfer into enteric neurons of the rat small intestine in organ culture using a replication defective recombinant herpes simplex virus type 1 (hsv1) vector, but not recombinant adenovirus vectors. | we have designed a system in which to test gene transfer into gut neurons consisting of an organ culture of neonatal rat small intestine. the tissue was exposed to herpes simplex- and adenovirus-derived vectors: (1) a temperature-sensitive herpes simplex virus-1 (hsv1) vector (tsk-beta gal) containing the lacz gene encoding beta-galactosidase (beta-gal), under the transcriptional control of the hsv1 immediate-early 3 (ie3) promoter; (2) rad35, an e1-/e3- replication-deficient adenovirus expressi ... | 1997 | 9176519 |
| antibodies against chlamydia pneumoniae, cytomegalovirus, enteroviruses and respiratory syncytial virus in patients with polymyalgia rheumatica. | to investigate the association between the onset of polymyalgia rheumatica (pmr) and prior or persistent infection with chlamydia pneumoniae or cytomegalovirus (cmv) (both known to infect the vessel wall) enteroviruses (ev) or respiratory syncytial virus (rsv). | 1997 | 9177926 |
| determinants and kinetics of cytokine expression patterns in lungs of vaccinated mice challenged with respiratory syncytial virus. | the development of a successful respiratory syncytial virus (rsv) vaccine will be advanced by an improved understanding of the pathogenesis of natural disease and vaccine-enhanced illness. using a murine model, we have examined cytokine message expression and cytokine secretion in lungs of mice primed with killed or live antigens and challenged with rsv. stable cytokine mrna expression was achieved if the prime-challenge interval was 2 weeks. the pattern of expression of interleukin-4 (il-4) and ... | 1997 | 9178456 |
| expression from cardiomyocyte-specific promoter after adenovirus-mediated gene transfer in vitro and in vivo. | adenoviruses are very attractive vectors for gene transfer into the cardiac muscle; however, their promiscuous tissue tropism, leading to an ectopic expression of the transgene, is a considerable practical limitation. to restrict expression of a reporter gene in cultured cardiomyocytes and in the heart of the rat, we have constructed a recombinant adenovirus (ad-mlc2 beta gal) containing the beta-galactosidase gene under the control of the rat ventricle-specific cardiac myosin light chain 2 (mlc ... | 1997 | 9181118 |
| nosocomial respiratory syncytial virus infections: prevention and control in bone marrow transplant patients. | to assess the effectiveness of a multifaceted infection control strategy in limiting the nosocomial transmission of respiratory syncytial virus (rsv) infection to patients in a bone marrow transplant (bmt) unit. | 1997 | 9181397 |
| [study on cellular immunity in children with respiratory syncytial virus associated acute lower respiratory infection]. | for exploring cellular immunity disturbances in children with acute lower respiratory infection (alri) caused by respiratory syncytial virus (rsv) the level of interleukin-2 (il-2) soluble interleukin-2 receptor (sil- 2r), the expression rate of interleukin-2 receptor (il-2r) on t cells and percentage of t lymphocyte subsets were determined in peripheral blood of 25 acute cases. the results showed that compared acute stage of rsv associated alri with recovery stage and control group, the level o ... | 1997 | 15617344 |
| [inhibition of respiratory syncytial virus (rsv) by moroxydine, allicin, alpha-interferon and their joint application]. | this paper reported the inhibition of respiratory syncytial virus by moroxydine (abob), allicin, alpha-interferon and their joint application. the results indicated that each of the three drugs inhibited rsv in hela cells, and the effective dosage of abob was 100 mg/l, alpha-interferon 1.5 x 10(4) u/l and allicin one eight hundred thousandth of the pure material. the combinations of 3 drugs showed synergism without antagonism, this not only decreased the dosage, toxicity but also enhanced the in ... | 1997 | 15617350 |
| respiratory viral infections in immunocompetent and immunocompromised persons. | the acute respiratory illnesses are the most common type of acute illness in the united states today. the respiratory viruses--which include influenza viruses, parainfluenza viruses, respiratory syncytial virus (rsv), rhinoviruses, coronaviruses, and adenoviruses--cause the majority of these illnesses. some of these viruses cause illness throughout the year, whereas others are most common in winter. all population groups experience these infections and illnesses. as the number of elderly persons ... | 1997 | 10868136 |
| community respiratory virus infections in immunocompromised patients with cancer. | community respiratory viruses, such as respiratory syncytial virus (rsv), influenza viruses, parainfluenza viruses, adenoviruses, and picornaviruses, are an important cause of respiratory disease in the immunocompromised adult with cancer. recent studies have demonstrated that a minimum of 31% of adult bone marrow transplant (bmt) recipients and 18% of adults with leukemia who are hospitalized with an acute respiratory illness have a community respiratory virus infection. the temporal occurrence ... | 1997 | 10868137 |
| community respiratory viruses in individuals with human immunodeficiency virus infection. | respiratory viruses, particularly influenza viruses, respiratory syncytial virus (rsv), parainfluenza viruses, and adenoviruses, are ubiquitous pathogens among humans, especially among young children. however, relatively little is known about the impact of these common infections on individuals with the human immunodeficiency virus (hiv). a review of the literature identifies three key areas that need further exploration. first, moderate-to-severe and even fatal lower respiratory viral illnesses ... | 1997 | 10868138 |
| respiratory virus infections after marrow transplant: the fred hutchinson cancer research center experience. | respiratory virus infections are becoming increasingly appreciated causes of morbidity and mortality in bone marrow transplant recipients. fred hutchinson cancer research center (fhcrc) has had considerable experience with respiratory syncytial virus (rsv), parainfluenza, influenza, and rhinovirus infections in these patients over the past decade. overall, rsv accounted for the majority of community-acquired respiratory virus infections (35%), followed by parainfluenza virus (30%), rhinovirus (2 ... | 1997 | 10868139 |
| community respiratory viruses: organ transplant recipients. | respiratory infections are common after solid organ transplantation, but the significance of community respiratory viral infections in this patient population has not been determined. review of the literature indicates that infection of organ transplant recipients by community respiratory viruses can result in significant morbidity with some associated mortality. these viruses include respiratory syncytial virus (rsv), parainfluenza virus (piv), influenza virus, and adenovirus. as in normal host ... | 1997 | 10868140 |
| infection control of nosocomial respiratory viral disease in the immunocompromised host. | among immunocompromised adults, such as bone marrow transplant recipients, more than half of respiratory viral infections are complicated by pneumonia, with an associated mortality rate > 50%. nosocomial transmission of respiratory viral pathogens, such as respiratory syncytial virus (rsv) and influenza, in the immunocompromised patient has been reported frequently and usually occurs during a community outbreak. in view of the poor outcome in this subset of patients, intensive efforts should be ... | 1997 | 10868143 |
| prevention and treatment of respiratory syncytial virus and parainfluenza viruses in immunocompromised patients. | immunocompromised patients are vulnerable to severe infections due to respiratory syncytial virus (rsv) and parainfluenza viruses (piv), and therefore prevention and treatment strategies must be considered. the prevention of rsv disease with high-titer rsv-specific immune globulin has been documented in very young children but has not been systematically studied in high-risk adults. vaccines against rsv and piv are under development, but their use in immunocompromised patients is problematic. ri ... | 1997 | 10868145 |
| detection and subgrouping of respiratory syncytial virus directly from nasopharyngeal aspirates. | objective: to develop a reverse transcription-polymerase chain reaction (rt-pcr)-based assay to identify the subgroup of the infecting respiratory syncytial virus (rsv) strain directly from nasopharyngeal aspirates (npas). methods: a total of 154 npas which were positive for rsv antigen by direct immunofluorescence were subjected to rt-pcr. the primers used were designed to give products for subgroup a and b which were of different sizes and easily visualized on agarose electrophoresis. the pcr ... | 1997 | 11864086 |
| regular pattern of respiratory syncytial virus and rotavirus infections and relation to weather in stockholm, 1984--1993. | objective: to seek the possible epidemiologic relationship between the two dominant pediatric infectious agents, respiratory syncytial virus (rsv) and rotavirus, and to analyze the relationship of rsv to influenza virus infections and climate. methods: in the laboratory register, we retrospectively identified pediatric cases less than 5 years of age from the period 1984--93 (including the winter of 1994). rsv was diagnosed by immunofluorescence in nasopharyngeal samples and rotavirus infections ... | 1997 | 11864206 |
| respiratory syncytial virus immune globulin. | respiratory syncytial virus (rsv) immune globulin is a purified human hyperimmune globulin that provides passive immunity against complicated rsv disease in select groups of infants and young children. according to microneutralisation assay results, its rsv-neutralising antibody concentration was significantly greater than that of nonspecific immune globulin, thereby suggesting the potential for more reliable protection against rsv infection. in 2 randomised double-blind trials, prophylaxis with ... | 1997 | 18020503 |
| perspectives for the chemotherapy of respiratory syncytial virus (rsv) infections. | respiratory syncytial virus (rsv) is the major respiratory pathogen in infants and young children. ribavirin is the only antiviral agent approved for the treatment of rsv infections, but its efficacy has remained controversial. in the past few years several compounds have been described that in vitro exhibit marked activity against rsv at a 50% effective concentration that is significantly lower, and with a selectivity index that is significantly higher, than that of ribavirin. among the most po ... | 1996 | 18611756 |
| [respiratory syncytial virus lower respiratory tract infection: our series]. | the authors report 57 cases of respiratory syncytial virus (rsv) lower respiratory tract infection. the diagnosis was performed by detection of specific serum antibodies of igm class or by direct detection of rsv antigens in nasopharyngeal specimens. most of the patients were younger than one year. no one had risk factors for severe rsv infection form. all patients recovered. the authors emphasize the difficulties to discriminate between bronchiolitis and interstitial pneumonitis on the basis of ... | 1996 | 12858027 |
| advances in the diagnosis of respiratory virus infections. | advances have been made in selecting sensitive cell lines for isolation, in early detection of respiratory virus growth in cells by rapid culture assays, in production of monoclonal antibodies to improve many tests such as immunofluorescence detection of virus antigens in nasopharyngeal aspirates, in highly sensitive antigen detections by time-resolved fluoroimmunoassays (tr-fias) and biotin-enzyme immunoassays (bioth-e), and, finally, in the polymerase chain reaction (pcr) detection of respirat ... | 1996 | 15566867 |
| detection of respiratory viruses in nasopharyngeal secretions with immunofluorescence technique for multiplex screening-an evaluation of the chemicon assay. | antigen detection with immunofluorescence is an efficient method for diagnosis of respiratory tract infections, but has previously not allowed for simple screening of many respiratory viruses. pools of monoclonal antibodies against various respiratory viruses are now available, and are potentially important tools for improvement of antigen detection in nasopharyngeal samples. | 1996 | 15566901 |
| [clinical, therapeutic and developmental aspects of acute bronchiolitis in tunisia]. | fourteen infants with severe acute bronchiolitis were admitted to the intensive care unit (icu) of tunis. this pathology represents 36% of severe bronchopulmonary infections admitted to this icu. their age ranged between 2 and 48 weeks (mean: 15 weeks). eight infants had hypotrophy. two infants had congenital heart disease and one infant had tracheo-bronchomalacia. viruses were found in 6/11 patients. respiratory syncytial virus (rsv) was identified in five patients and an adenovirus in one pati ... | 1996 | 9183423 |
| stable expression of anti-hpv 16 e7-ribozyme in cv-1 cell lines. | the hpv16 (human papilloma virus type 16) e7 gene product, an oncoprotein, has been considered to be involved in the pathogenesis of anogenital cancer, particularly of cervical cancer. in order to evaluate the effect of suppression of the expression of the e7 gene in cv-1 cells by ribozyme, rz523 with a transacting ribozyme targeted to the e7 rna and two processing ribozyme genes at the 5' and 3' flank was cloned into the eukaryotic expression plasmid prep9 under the control of rsv-ltr promoter. ... | 1996 | 9187492 |
| cell-mediated immune responses of lambs to experimental infection with bovine respiratory syncytial virus. | primary infection of lambs with bovine respiratory syncytial virus (rsv) was characterised by the presence of virus-specific cytotoxic cells in the peripheral blood as early as 5 days post-infection. these effector cells lysed virus-infected autologous targets in a self-restricted manner. depletion techniques revealed that cytotoxic activity was largely due to ovcd8+ cells. neutrophils obtained from experimentally infected lambs 5 to 10 days post-inoculation exhibited significant cytotoxic activ ... | 1996 | 9157688 |
| antigens of bovine respiratory syncytial virus in peripheral blood lymphocytes of experimentally infected lambs. | eight lambs were experimentally infected with bovine respiratory syncytial virus (rsv) and the distribution of viral antigen in lymphocyte subpopulations studied by flow cytometry. experimental infection with bovine rsv was characterised by significant changes in lymphocyte subpopulations. infection was followed by a significant (p <0.001) reduction in the number of cells expressing the ovcd5 epitope (t cells), due to a fall in the number of cells expressing the ovcd4 epitope (helper) and those ... | 1996 | 9157689 |
| respiratory syncytial virus infection in the elderly. | respiratory syncytial virus (rsv) is the most common cause of lower respiratory tract infections in infants and children throughout the world. respiratory syncytial virus infections in the elderly represent reinfections in the hosts who have had many prior episodes. thus, rsv infections are usually not considered serious in adults, since reinfections are generally known to result in mild disease. nevertheless, in adults, as in children, the infection has been reported to cause altered airway res ... | 1996 | 9072495 |