Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| hypoxia-inducible factor 1 and its role in viral carcinogenesis. | the advent of modern molecular biology has allowed for the discovery of several mechanisms by which oncoviruses promote carcinogenesis. remarkably, nearly all human oncogenic viruses increase levels of the transcription factor hypoxia-inducible factor 1 (hif-1). in this review, we highlight hif-1׳s significance in viral oncogenesis, while providing an in-depth analysis of its activation mechanisms by the following oncoviruses: human papillomaviruses (hpvs), hepatitis b/c viruses (hbv/hcvs), epst ... | 2014 | 24698149 |
| clinicopathologic, immunophenotypic, and eber in situ hybridization study of extranodal natural killer/t-cell lymphoma, nasal type in ãmulti-ethnic groups. | extranodal nasal-type nk/t-cell lymphoma (enktcl) is a common and geographic predominant disease in china. we observed the clinical and pathologic features of this tumor type and its relationship to epstein-barr virus (ebv), and focused on the epidermology and prevalence of enktcl in xinjiang, in order to improve the diagnostic and differential diagnosis ability. | 2014 | 24697118 |
| ct features and pathologic characteristics of lymphoepithelial carcinoma of salivary glands. | to investigate and analyze the typical ct findings of salivary gland lymphoepithelial carcinoma. | 2014 | 24696717 |
| editorial commentary: genetics and infectious mononucleosis. | 2014 | 24696239 | |
| a genetic basis for infectious mononucleosis: evidence from a family study of hospitalized cases in denmark. | circumstantial evidence from genome-wide association and family studies of various epstein-barr virus-associated diseases suggests a substantial genetic component in infectious mononucleosis (im) etiology. however, familial aggregation of im has scarcely been studied. | 2014 | 24696238 |
| evaluation and management of neck masses in children. | neck masses in children usually fall into one of three categories: developmental, inflammatory/reactive, or neoplastic. common congenital developmental masses in the neck include thyroglossal duct cysts, branchial cleft cysts, dermoid cysts, vascular malformations, and hemangiomas. inflammatory neck masses can be the result of reactive lymphadenopathy, infectious lymphadenitis (viral, staphylococcal, and mycobacterial infections; cat-scratch disease), or kawasaki disease. common benign neoplasti ... | 2014 | 24695506 |
| developing a potentially immunologically inert tetracycline-regulatable viral vector for gene therapy in the peripheral nerve. | viral vector-mediated gene transfer of neurotrophic factors is an emerging and promising strategy to promote the regeneration of injured peripheral nerves. unfortunately, the chronic exposure to neurotrophic factors results in local trapping of regenerating axons or other unwanted side effects. therefore, tight control of therapeutic gene expression is required. the tetracycline/doxycycline-inducible system is considered to be one of the most promising systems for regulating heterologous gene ex ... | 2014 | 24694534 |
| [primary cns lymphoma--an update]. | primary central nervous system lymphomas (pcnsl) in immunocompetent patients have long suffered from their rarity. biological studies as well as initiation of comparative prospective therapeutic studies have been delayed in this population. a significant improvement in survival was observed when radiotherapy was preceded by chemotherapy with high dose methotrexate (mtx). median survival improved from 16 months, with radiotherapy alone, to 35-45 months with combined treatments, at the cost of a r ... | 2014 | 24691194 |
| primary epstein-barr virus infection diffusing f18-fluorodeoxyglucose-positron emission tomography/computed tomography response monitoring of hodgkin's disease: a case report. | hodgkin's disease is highly curable by radiotherapy and/or chemotherapy, but refractory disease or early relapses are rarely cured by conventional salvage therapy. | 2014 | 24950966 |
| secondary diffuse large b-cell lymphoma after chemotherapy for acute myeloid leukemia: looking for the unexpected diagnosis. | development of epstein-barr virus (ebv) positive lymphoproliferative disorders in patients with immunosuppression has become more frequently reported. a patient with acute myeloid leukemia was treated to remission, when on follow-up 9 months after his initial diagnosis, he was noted to have a generalized rash and lymphadenopathy. evaluation of skin and bone marrow biopsies was suggestive of a relapsed leukemia, and treatment was initiated. fever evaluation revealed a high load of ebv in his bloo ... | 2014 | 24950422 |
| a computationally designed inhibitor of an epstein-barr viral bcl-2 protein induces apoptosis in infected cells. | because apoptosis of infected cells can limit virus production and spread, some viruses have co-opted prosurvival genes from the host. this includes the epstein-barr virus (ebv) gene bhrf1, a homolog of human bcl-2 proteins that block apoptosis and are associated with cancer. computational design and experimental optimization were used to generate a novel protein called bindi that binds bhrf1 with picomolar affinity. bindi recognizes the hydrophobic cleft of bhrf1 in a manner similar to other bc ... | 2014 | 24949974 |
| [some aspects of the treatment of adult patients with epstein-barr virus infection]. | the review analyzes the basic aspects of treatment policy in patients with different forms of epstein-barr virus infection. practical recommendations are given on the basis of the extensive literature data published in the past 20 years. | 2014 | 24754076 |
| long-term outcome after haploidentical stem cell transplant and infusion of t cells expressing the inducible caspase 9 safety transgene. | adoptive transfer of donor-derived t lymphocytes expressing a safety switch may promote immune reconstitution in patients undergoing haploidentical hematopoietic stem cell transplant (haplo-hsct) without the risk for uncontrolled graft versus host disease (gvhd). thus, patients who develop gvhd after infusion of allodepleted donor-derived t cells expressing an inducible human caspase 9 (ic9) had their disease effectively controlled by a single administration of a small-molecule drug (ap1903) tha ... | 2014 | 24753538 |
| risk of diffuse large b-cell lymphoma after solid organ transplantation in the united states. | non-hodgkin lymphoma arising in the context of immunosuppression is an important adverse outcome after solid organ transplantation. diffuse large b-cell lymphoma (dlbcl) is the most commonly diagnosed subtype of post-transplantation non-hodgkin lymphoma, but few studies of transplant recipients have examined subtype-specific risks. therefore, we examined dlbcl risk in the transplant cancer match study, including registry-based cancer ascertainment among 96,615 solid organ transplants performed f ... | 2014 | 24753070 |
| new brain lesions in a patient with sarcoidosis: is it neurosarcoidosis? | a 45-year-old woman with pulmonary sarcoidosis diagnosed 5 years previously, who was on treatment with prednisone and methotrexate for 1year, developed partial seizure with secondary generalization. mri showed three non-cavitary enhancing lesions in the cerebello-occipital region. these lesions were presumed to be neurosarcoidosis. methotrexate was discontinued, prednisone dose was increased and azathiopurine and levetiracetam were added. while on treatment, follow up imaging showed enlarging br ... | 2014 | 24751455 |
| an elderly patient with chronic active epstein-barr virus infection with severe hydroa vacciniforme-like eruptions associated with αβt-cell proliferation. | 2014 | 24628134 | |
| novel functional small rnas are selectively loaded onto mammalian ago1. | argonaute (ago) proteins function in rna silencing as components of the rna-induced silencing complex (risc). in lower organisms, the small interfering rna and mirna pathways diverge due in part to sorting mechanisms that direct distinct small rna (srna) duplexes onto specific ago-riscs. however, such sorting mechanisms appear to be lost in mammals. mirnas appear not to distinguish among ago1-4. to determine the effect of viral infection on the sorting system, we compared the content of deep-seq ... | 2014 | 24627180 |
| oncogenic effects of wnt5a in epstein-barr virus‑associated nasopharyngeal carcinoma. | the molecular events that drive the progression of epstein-barr virus (ebv)-associated nasopharyngeal carcinoma (npc) are still to be elucidated. here, we report for the first time the pathogenic significance of an npc-associated gene, wingless-type mmtv integration site family, member 5a (wnt5a) and the contribution of ebv to its expression. wnt5a is a representative wnt protein that activates non-canonical wnt signalling. with regard to its role in carcinogenesis, there is conflicting evidence ... | 2014 | 24626628 |
| evaluation of the architect epstein-barr virus (ebv) viral capsid antigen (vca) igg, vca igm, and ebv nuclear antigen 1 igg chemiluminescent immunoassays for detection of ebv antibodies and categorization of ebv infection status using immunofluorescence assays as the reference method. | commercial immunoassays for detecting igg and igm antibodies against epstein-barr virus (ebv), viral capsid antigens (vca), and iggs toward ebv nuclear antigen-1 (ebna-1) are routinely used in combination to categorize ebv infection status. in this study, we evaluated the performances of the architect ebv vca igg, vca igm, and ebna-1 igg chemiluminescent microparticle assays (cmias) in ebv serological analyses using indirect immunofluorescence assays and anticomplement immunofluorescence assays ... | 2014 | 24623623 |
| epstein-barr virus-positive primary cutaneous diffuse large b-cell lymphoma in an immunocompetent patient. | 2014 | 24648701 | |
| mcaf1 and rta-activated bzlf1 transcription in epstein-barr virus. | epstein-barr virus (ebv) expresses two transcription factors, rta and zta, which are involved in the transcriptional activation of ebv lytic genes. this study sought to elucidate the mechanism by which rta activates transcription of the zta-encoding gene, bzlf1, through the zii element in the gene promoter. in a dna affinity precipitation assay, atf2 was found to associate with an rta-interacting protein, mcaf1, at the zii element. the interaction between rta, mcaf1, and atf2 at the same site in ... | 2014 | 24598729 |
| t-cell therapy using a bank of ebv-specific cytotoxic t cells: lessons from a phase i/ii feasibility and safety study. | we report herein the results we obtained and the limitations we experienced during the production and use of a bank of epstein-barr virus (ebv)-transformed human cytotoxic t lymphocytes (ebv-ctls). to assess the feasibility and toxicity of this strategy, we selected and stored, in liquid nitrogen, 4 billion ebv-ctls from each of the 13 selected donors. subsequently, in a multicenter phase i/ii study, 11 patients with ebv-associated lymphoma resistant to conventional treatments received 1-3 doses ... | 2014 | 24598452 |
| human papillomavirus and epstein barr virus in head and neck carcinomas: suggestions for the new who classification. | in the 9 years since the last world health organization (who) classification for head and neck tumors, a great deal has changed. in particular, human papillomavirus (hpv) has emerged as the major etiologic agent and patient prognostic marker for squamous cell carcinoma, most profoundly in the oropharynx. it also casts a long shadow over all of the rest of head and neck cancer given its biologic and prognostic implications. by contrast, little has changed regarding our knowledge of epstein-barr v ... | 2014 | 24595417 |
| comparison of clinical features and ebv expression in histiocytic necrotizing lymphadenitis of children and adults. | histiocytic necrotizing lymphadenitis (hnl) is a self-limiting disease characterized by cervical lymphadenopathy and fever. epstein-barr virus (ebv) has been implicated as a cause of hnl in some reports but not in others. the aim of this study was to compare the clinical features and laboratory findings in children and adults with hnl and to evaluate the relationship between ebv infection and hnl. | 2014 | 24594231 |
| inflammatory pseudotumor of spleen. | inflammatory pseudotumor (ipt) is an uncommon tumor and its occurrence in spleen is rare. this tumor is composed of proliferation of spindle cells of unknown origin and etiology that mimic other tumors at clinical and histological evaluation. the most surmising etiology is epstein barr virus (ebv) and the most suspected origin is myofibroblasts, hence its synonym is "inflammatory myofibroblastic tumor." the clinical appearance of tumor is related to its location but the most ones are abdominal p ... | 2014 | 24592376 |
| primary hodgkin lymphoma of the central nervous system. | primary involvement of the central nervous system by hodgkin lymphoma is rare; most cases represent metastases. we report a primary hodgkin lymphoma presenting in the cerebellum of a 77-year-old man and review the literature on primary hodgkin lymphoma of the central nervous system. | 2014 | 24589557 |
| cellular immune controls over epstein-barr virus infection: new lessons from the clinic and the laboratory. | epstein-barr virus (ebv), a human herpesvirus with potent b cell growth transforming ability, induces multiple cellular immune responses in the infected host. how these host responses work together to prevent virus pathogenicity, and how immune imbalance predisposes to disease, remain poorly understood. here, we describe three ongoing lines of enquiry that are shedding new light on these issues. these focus on: (i) patients with infectious mononucleosis or its fatal equivalent, x-linked lymphopr ... | 2014 | 24589417 |
| role of the histone h3 lysine 9 methyltransferase suv39 h1 in maintaining epsteinn-barr virus latency in b95-8 cells. | the ability of epstein-barr virus (ebv) to establish latent infection is associated with infectious mononucleosis and a number of malignancies. in ebv, the product of the bzlf1 gene (zebra) acts as a master regulator of the transition from latency to the lytic replication cycle in latently infected cells. ebv latency is primarily maintained by hypoacetylation of histone proteins in the bzlf1 promoter by histone deacetylases. although histone methylation is involved in the organization of chromat ... | 2014 | 24588869 |
| specific aspects of modern life for people with multiple sclerosis: considerations for the practitioner. | multiple sclerosis (ms) is a chronic, debilitating, neurodegenerative disease that has a high impact on patients' quality of life. individuals are often diagnosed in early adulthood and are faced with the difficulty of managing their lifestyle within the context of this chronic illness. here we review factors that influence the disease course and the challenges that might be encountered when managing patients with ms. the majority of diagnosed patients are women of childbearing age, making pregn ... | 2014 | 24587828 |
| transcriptomic profile reveals gender-specific molecular mechanisms driving multiple sclerosis progression. | although the most common clinical presentation of multiple sclerosis (ms) is the so called relapsing-remitting ms (rrms), the molecular mechanisms responsible for its progression are currently unknown. to tackle this problem, a whole-genome gene expression analysis has been performed on rrms patients. | 2014 | 24587374 |
| rna compass: a dual approach for pathogen and host transcriptome analysis of rna-seq datasets. | high-throughput rna sequencing (rna-seq) has become an instrumental assay for the analysis of multiple aspects of an organism's transcriptome. further, the analysis of a biological specimen's associated microbiome can also be performed using rna-seq data and this application is gaining interest in the scientific community. there are many existing bioinformatics tools designed for analysis and visualization of transcriptome data. despite the availability of an array of next generation sequencing ... | 2014 | 24586784 |
| the epstein-barr virus-encoded microrna mir-bart9 promotes tumor metastasis by targeting e-cadherin in nasopharyngeal carcinoma. | micrornas (mirnas) are a family of small rna molecules that negatively regulate the expression of protein-coding genes and play critical roles in orchestrating diverse cellular processes. this regulatory mechanism is also exploited by viruses to direct their life cycle and evade the host immune system. epstein-barr virus (ebv) is an oncogenic virus that is closely associated with multiple human diseases, including nasopharyngeal carcinoma (npc), which is a highly metastatic type of tumor and is ... | 2014 | 24586173 |
| prevalence of human papillomavirus and epstein-barr virus dna in chinese children with tonsillar and/or adenoidal hypertrophy. | tonsillar and adenoidal hypertrophy are prevalent otolaryngologic disorders in children, but their pathogenesis is largely unknown. the presence of human papillomavirus (hpv) and epstein-barr virus (ebv) dna in 146 tonsil and/or adenoid tissue specimens from 104 chinese children with tonsillar and/or adenoidal hypertrophy were screened using flow-through hybridization gene-chip technology and real-time fluorescence-based quantitative pcr. then, the relationships between the prevalence of the vir ... | 2014 | 24615954 |
| sequence analysis of ebv immediate-early gene bzlf1 and brlf1 in lymphomas. | the immediate-early (ie) genes, bzlf1 and brlf1, play an important role in switching epstein-barr virus from the latent to the lytic state. the functions of the two ie genes and their respective proteins: zebra and rta have been well studied, but little is known about their dna coding sequence variations and disease association. in order to investigate the sequence variation patterns and elucidate their association with lymphomas, bzlf1 and brlf1 were analyzed in 26 and 33 lymphomas using pcr-di ... | 2014 | 24615673 |
| down-regulation of mirna-204 by lmp-1 enhances cdc42 activity and facilitates invasion of ebv-associated nasopharyngeal carcinoma cells. | nasopharayngeal carcinoma (npc) is an epstein-barr virus (ebv)-associated malignancy. it is known that micrornas are implicated in the progression of npc. however, the role of mir-204 in npc is poorly understood. in this study, we found that mir-204 was down-regulated in npc cells and tissues. low-level expression of mir-204 was significantly associated with a more aggressive and poor prognostic phenotype of npc. we further found that ebv-encoded latent membrane protein 1 (lmp-1) suppressed mir- ... | 2014 | 24613926 |
| antineutrophil cytoplasmic antibody-associated vasculitis associated with epstein-barr virus infection: a case report and review of the literature. | a 16-year-old female with fever was admitted to our hospital. on admission, her serum igm antibody against epstein-barr virus (ebv) was positive. then, the disease aggravated and acute kidney injury occurred gradually. antineutrophil cytoplasmic autoantibody (anca)-associated vasculitis (aav) was confirmed by serum test and kidney biopsy. the patient was treated with oral methylprednisolone. along with the disappearance of the igm anti-ebv antibody, the aav also relieved without relapse during f ... | 2014 | 24610176 |
| in reference to "use of the lymphocyte count as a diagnostic screen in adults with suspected epstein-barr virus infectious mononucleosis". | 2014 | 24610140 | |
| chronic active epstein-barr virus infection mimicking autoimmune hepatitis exacerbation in a patient with systemic lupus erythematosus. | chronic active epstein-barr virus infection (caebv) is characterized by chronic infectious mononucleosis-like symptoms. we report a very rare case with autoimmune hepatitis (aih) complicated by caebv. a 50-year-old woman with systemic lupus erythematosus (sle) complicated by aih began to suffer from acute respiratory failure and her clinical symptoms improved rapidly in response to steroid treatment. however, during the gradual tapering of the steroid dose, a steady increase of the serum hepatob ... | 2014 | 24608961 |
| best practices in the management of the psycho-oncologic aspects of head and neck cancer patients: recommendations from the european head and neck cancer society make sense campaign. | squamous cell carcinoma of the head and neck (scchn) is considered a worldwide health care problem. the majority of patients have a history of alcohol abuse and high-level tobacco consumption; however, scchn is also associated with exposure to viruses including human papillomavirus (hpv) and epstein-barr virus. a major problem facing scchn patients is that their disease is often diagnosed at an advanced stage where treatment options may not be curative, or can have severe post-treatment conseque ... | 2014 | 24608199 |
| acute epstein-barr virus infection and human immunodeficiency virus antibody cross-reactivity. | 2014 | 24608015 | |
| epstein barr virus: a prime candidate of breast cancer aetiology in sudanese patients. | breast cancer is the commonest cancer in sudanese women. reported genetic alterations in the form of mutations in tumor suppressors are low in frequencies and could not explain the peculiarities of the diseases including its focal nature. potential contributors disease aetiology include oncogenic viruses such as epstein-barr virus (ebv), an established culprit of nasopharyngeal carcinoma, one of the most frequent cancers in sudan.in this study, dna was extracted from malignant tissue samples and ... | 2014 | 24607238 |
| expression of epstein-barr virus-encoded latent membrane protein (lmp-1), p16 and p53 proteins in nonendemic nasopharyngeal carcinoma (npc): a clinicopathological study. | although the latent membrane protein type 1 (lmp1) is frequently expressed in epstein-barr virus (ebv) malignancies, its contribution to the pathogenesis of nasopharyngeal carcinoma (npc) is not fully defined. lmp1 functions as a viral mimic of the tnfr family member engaging a number of signaling pathways that induce morphological and phenotypic alterations. this study aimed to investigate the lmp1 expression and ebv infection in relation to clinical outcome and survival in a series of mexican ... | 2014 | 24606815 |
| a new model of lmp1-myc interaction in b cell lymphoma. | epstein-barr virus (ebv) is associated with aggressive b cell lymphomas (bcls). latent membrane protein 1 (lmp1) of ebv is an oncogenic protein required for ebv b cell transformation. however, lmp1 is a weak oncogene in mice. mice expressing myc inserted 5' of the eμ enhancer (imyc(eμ)), mimicking the t(8;14) translocation of endemic burkitt lymphoma, develop delayed onset bcls. to investigate potential cooperation between lmp1 and oncogenic myc, we produced mice expressing the lmp1 signaling do ... | 2014 | 24605938 |
| reproduction of epstein-barr virus infection and pathogenesis in humanized mice. | epstein-barr virus (ebv) is etiologically associated with a variety of diseases including lymphoproliferative diseases, lymphomas, carcinomas, and autoimmune diseases. humans are the only natural host of ebv and limited species of new-world monkeys can be infected with the virus in experimental conditions. small animal models of ebv infection, required for evaluation of novel therapies and vaccines for ebv-associated diseases, have not been available. recently the development of severely immunod ... | 2014 | 24605074 |
| genetics of epstein-barr virus micrornas. | the epstein-barr virus encodes at least 44 micrornas that are grouped in two clusters located around the bhrf1 gene and within the bart transcript. the expression pattern of these micrornas both depends on the lineage of the infected cells and on the type of viral latency. whilst bart micrornas are expressed in all ebv-infected tumors, the bhrf1 locus is nearly exclusively expressed in cells that display a type iii latency. however, the bart microrna expression level is several orders of magnitu ... | 2014 | 24602823 |
| analysis of host gene expression changes reveals distinct roles for the cytoplasmic domain of the epstein-barr virus receptor/cd21 in b-cell maturation, activation, and initiation of virus infection. | epstein-barr virus (ebv) attachment to human cd21 on the b-cell surface initiates infection. whether cd21 is a simple tether or conveys vital information to the cell interior for production of host factors that promote infection of primary b cells is controversial, as the cytoplasmic fragment of cd21 is short, though highly conserved. the ubiquity of cd21 on normal b cells, the diversity of this population, and the well-known resistance of primary b cells to gene transfer technologies have all i ... | 2014 | 24600013 |
| infectious mononucleosis accompanied by clonal proliferation of ebv-infected cells and infection of cd8-positive cells. | a 22-year-old male was admitted for a sustained fever of 2 months, lymphadenopathy, and liver dysfunction. anti-vca-igm antibody was positive, with elevated epstein-barr virus (ebv)-dna load in the peripheral blood. liver biopsy revealed infiltration of cd8-positive and ebv-positive cells. most peripheral blood mononuclear cells (pbmcs) were also positive for cd8, and showed detectable levels of ebv-dna. monoclonal proliferation of ebv-infected cells was detected in the pbmcs by southern blottin ... | 2014 | 24643771 |
| epstein-barr virus and mycobacterium avium subsp. paratuberculosis peptides are cross recognized by anti-myelin basic protein antibodies in multiple sclerosis patients. | epstein-barr virus and mycobacterium avium subsp. paratuberculosis (map) have been associated to multiple sclerosis (ms). we searched for antibodies against the homologous peptides epstein-barr virus nuclear antigen 1 (ebna1)400-413, map_0106c protein (map)121-132, and myelin basic protein (mbp)85-98 on a ms sardinian cohort, showing that these antibodies are highly prevalent among ms patients compared to healthy controls. competitive assay demonstrated that antibodies recognizing ebna1400-413 a ... | 2014 | 24642384 |
| pretreatment epstein-barr virus dna load and cumulative cisplatin dose intensity affect long-term outcome of nasopharyngeal carcinoma treated with concurrent chemotherapy: experience of an institute in an endemic area. | we retrospectively compared the long-term efficacy of concurrent chemoradiotherapy (ccrt) regimens (docetaxel vs. cisplatin), total dose intensity of cisplatin (> 200 vs. ≤ 200 mg/m2) and pretreatment plasma levels of epstein-barr virus (ebv) dna for nasopharyngeal carcinoma (npc), and investigated the prognostic factors. | 2014 | 24685911 |
| higher incidence of epstein-barr virus-induced lymphocyte transformation in multiple sclerosis. | epstein-barr virus (ebv) infection is associated with multiple sclerosis (ms), and ebv may transform lymphoblastoid cell lines more frequently in ms patients than controls, but it is not clear whether this reflects a higher viral load or an enhanced ability to reactivate ebv. | 2014 | 24684660 |
| paired study of 172 cases of nasopharyngeal carcinoma with or without dermatomyositis. | the prognosis and late adverse effects of radiotherapy (rt) in the patients with nasopharyngeal carcinoma (npc) with or without dermatomyositis (dm) were similar, although the npc patients with dm had higher epstein-barr virus (ebv) vca-iga titers and more severe acute side effects. gender, tnm stage, and chemotherapy were independent prognostic factors of overall survival for npc with dm. glucocorticoid treatment did not affect the survival of npc patients with dm. | 2014 | 24909624 |
| epstein-barr virus reactivation and hemophagocytic lymphohistiocytosis in a patient with chronic lymphocytic leukemia. | 2014 | 24660849 | |
| epstein-barr virus infection in an elderly nonimmunocompromised adult successfully treated with rituximab. | epstein-barr virus (ebv) is a ubiquitous virus that commonly affects children and adolescents. in addition to causing a viral illness, it is also associated with various malignancies in particular b cell lymphomas and lymphoproliferative disorders. differentiating between the two processes can be a diagnostic challenge. here, we present a case of an atypical ebv infection in an elderly patient with severe systemic symptoms, multiorgan involvement, lymphadenopathy, and negative ebv serology. exci ... | 2014 | 24660077 |
| cutaneous lymphomas: an update. part 2: b-cell lymphomas and related conditions. | : primary cutaneous b-cell lymphomas (pcbcl) are the second most common form of primary cutaneous lymphomas and account for approximately 25%-30% of all primary cutaneous lymphomas. both forms of low-grade malignant pcbcl, primary cutaneous follicle center lymphoma (pcfcl) and primary cutaneous marginal zone lymphoma of mucosa-associated lymphoid tissue-type (malt lymphoma) (pcmzl) represent the vast majority of pcbcl and show an indolent slowly progressive course and an excellent prognosis desp ... | 2014 | 24658377 |
| ebv-encoded mir-bart20-5p and mir-bart8 inhibit the ifn-γ-stat1 pathway associated with disease progression in nasal nk-cell lymphoma. | nasal nk-cell lymphoma (nnl) is an epstein-barr virus (ebv)-associated lymphoma of cytotoxic natural killer (nk) cell origin. because normal nk cells secrete the principal cytotoxic cytokine ifn-γ to suppress both tumor growth and viral replication, we investigated how ebv may have used mirnas of viral origin to inhibit the ifn-γ-stat1 pathway to facilitate viral replication and tumor growth. in ebv(-) jurkat cells, transfection of mir-bart20-5p and mir-bart8 inhibited translation of luciferase- ... | 2014 | 24655378 |
| virology. epstein-barr virus turns 50. | 2014 | 24653027 | |
| early detection of nasopharyngeal carcinoma using iga anti-ebna1 + vca-p18 serology assay. | nasopharyngeal carcinoma (npc) is the most common head and neck malignancy in indonesia. overall, it ranks fourth in males and sixth in females as the most prevalent type of cancer in that country. the data show that in the year 2011, npc incidence was considered to be intermediate (6.2/100,000 population per year). through histopathologic examination, about 70 to 80% of these cases were found to be type iii according to the who classificaton. npc carries an excellent prognosis if treated early, ... | 2014 | 24652560 |
| oncogenic viral prevalence in invasive vulvar cancer specimens from human immunodeficiency virus-positive and -negative women in botswana. | the primary aim of this study was to describe the prevalence of select oncogenic viruses within vulvar squamous cell carcinoma (vscc) and their association with human immunodeficiency virus (hiv) status in women in botswana, where the national hiv prevalence is the third highest in the world. | 2014 | 24651632 |
| expression of dual-specificity phosphatase 5 pseudogene 1 (dusp5p1) in tumor cells. | sequencing of individual clones from a newly established cdna library from the chemoresistant hodgkin's lymphoma cell line l-1236 led to the isolation of a cdna clone corresponding to a short sequence from chromosome 1. reverse transcriptase-polymerase chain reaction indicated high expression of this sequence in hodgkin's lymphoma derived cell lines but not in normal blood cells. further characterization of this sequence and the surrounding genomic dna revealed that this sequence is part of a hu ... | 2014 | 24651368 |
| systemic inflammatory response syndrome after administration of unmodified t lymphocytes. | systemic inflammatory response syndrome (sirs) is a rare systemic inflammatory response associated with fever, tachycardia, profound hypotension, and respiratory distress, which has been reported in cancer patients receiving t cells genetically modified with chimeric antigen receptors to retarget their specificity to tumor-associated antigens. the syndrome usually occurs following significant in vivo expansion of the infused cells and has been associated with tumor destruction/lysis. analysis of ... | 2014 | 24651135 |
| the epidemiology of infectious mononucleosis in northern scotland: a decreasing incidence and winter peak. | infection with epstein-barr virus (ebv) is almost ubiquitous in humans and generally occurs at two ages: infantile, which is usually asymptomatic and associated with poorer socioeconomic conditions, and adolescent, which causes infectious mononucleosis (im) in ~25% cases. the determinants of whether the infection causes im remain uncertain. we aimed to evaluate seasonality and temporal trends in im. | 2014 | 24650116 |
| [reamberin optimizes drug therapy in children with acute epstein-barr viral infection]. | the efficacy of a 1.5% reamberin solution possessing detoxicating, antihypoxant, antioxidant, and membrane-protective properties, used as a component of the complex infusion therapy in children with acute epstein-barr virus infection, has been estimated. the dynamics of the inflammatory process in children treated by the drug complex including reamberin is characterized by rapid relief of general symptoms, improvement of state, and reduction in length of the febrile period of disease as compared ... | 2014 | 24649599 |
| stat3 interrupts atr-chk1 signaling to allow oncovirus-mediated cell proliferation. | dna damage response (ddr) is a signaling network that senses dna damage and activates response pathways to coordinate cell-cycle progression and dna repair. thus, ddr is critical for maintenance of genome stability, and presents a powerful defense against tumorigenesis. therefore, to drive cell-proliferation and transformation, viral and cellular oncogenes need to circumvent ddr-induced cell-cycle checkpoints. unlike in hereditary cancers, mechanisms that attenuate ddr and disrupt cell-cycle che ... | 2014 | 24639502 |
| tracheal ulcer due to epstein-barr virus-positive diffuse large b-cell lymphoma of the elderly. | a 74-year-old man was referred to our hospital because of a tracheal stenosis circumscribed with soft tissue density and a left pulmonary nodule. open biopsy of a right submandibular lymph node revealed diffuse large b-cell lymphoma, and the malignant cells were positive for epstein-barr virus gene products. bronchofiberscopy revealed a tracheal necrotizing ulcer. after chemotherapy, the tracheal ulcer resolved. to our knowledge, this is the first report of a case of epstein-barr virus-positive ... | 2014 | 24636272 |
| posttransplant lymphoproliferative disorder after liver and kidney transplant. | we evaluated posttransplant lymphoproliferative disorder after solid-organ transplant. | 2014 | 24635813 |
| t-cell acute lymphoblastic leukemia after liver transplant. | t-cell posttransplant lymphoproliferative disorders after solid-organ transplant are rare and may be clinically aggressive. a 3-year-old boy had liver transplant from his grandfather because of hepatoblastoma. the immunosuppressive regimen was based on tacrolimus and prednisolone. at 22 months after transplant (age, 5 years), the patient presented to the hospital because of severe cough. computed tomography scan of the chest showed a large left mediastinal mass (9 × 7.2 × 7 cm) and left pleural ... | 2014 | 24635812 |
| burkitt lymphoma after transplant: an aggressive lymphoproliferative disease. | posttransplant lymphoproliferative disorder (burkitt lymphoma) may occur after liver transplant. a 3.5-year-old boy who was 17 months after liver transplant developed multiple millimeter-sized nodular lesions in the liver. before transplant, the patient tested seronegative for epstein-barr virus; within 1 month after transplant, he tested seropositive for epstein-barr virus (1000 copies). biopsy of the liver nodules showed posttransplant lymphoproliferative disorder (burkitt lymphoma). tacrolimu ... | 2014 | 24635811 |
| recurrence of primary sclerosing cholangitis in pediatric liver transplant recipients. | there is little detailed clinical information on recurrent primary sclerosing cholangitis (rpsc) after liver transplantation in children. our purpose was to describe the characteristics of children who had experienced rpsc after liver transplantation so that we could identify potential risk factors for recurrence. clinical information for pediatric patients undergoing transplantation for primary sclerosing cholangitis (psc) was retrospectively reviewed, and variables related to the pretransplant ... | 2014 | 24634351 |
| in response to "use of the lymphocyte count as a diagnostic screen in adults with suspected epstein-barr virus infectious mononucleosis". | 2014 | 24633810 | |
| g-quadruplexes regulate epstein-barr virus-encoded nuclear antigen 1 mrna translation. | viruses that establish latent infections have evolved unique mechanisms to avoid host immune recognition. maintenance proteins of these viruses regulate their synthesis to levels sufficient for maintaining persistent infection but below threshold levels for host immune detection. the mechanisms governing this finely tuned regulation of viral latency are unknown. here we show that mrnas encoding gammaherpesviral maintenance proteins contain within their open reading frames clusters of unusual str ... | 2014 | 24633353 |
| epstein-barr virus latent membrane protein-2a alters mitochondrial dynamics promoting cellular migration mediated by notch signaling pathway. | recently, migration and invasion of breast cancer cells have been linked with dysregulated mitochondrial dynamics. mitochondria are essential cellular organelles that undergo continuous dynamic cycles of fission and fusion. it has been proposed that a delicate balance between these two processes is important for many pathophysiological outcomes including cancer. epstein-barr virus (ebv) is a gamma herpesvirus that is associated with various lymphoid and epithelial malignancies. the viral latent ... | 2014 | 24632494 |
| epstein-barr virus positive inflammatory pseudo-tumour of the spleen: a case report and literature review. | epstein-barr virus positive inflammatory pseudo-tumour (ipt) of the spleen is an uncommon, frequently asymptomatic entity, which is typically picked up as an incidental finding on imaging. | 2014 | 24632301 |
| progress, prospects, and problems in epstein-barr virus vaccine development. | epstein-barr virus (ebv) is responsible for a farrago of acute and chronic human diseases including cancer. a prophylactic vaccine could reduce this disease burden. several ebv vaccines have been given to humans but none has been sufficiently studied to establish safety and efficacy. ebv vaccine development has been hampered by the lack of an animal model other than subhuman primates, proprietary issues, selection of an appropriate adjuvant, and failure to reach consensus on what an ebv vaccine ... | 2014 | 24632197 |
| dna-based hybridization chain reaction for an ultrasensitive cancer marker ebna-1 electrochemical immunosensor. | an ultrasensitive and selective electrochemical immunosensor was developed for the detection of epstein barr virus nuclear antigen 1 (ebna-1). firstly, a suspension of graphene sheets (gs) and multi-walled carbon nanotubes (mwcnts) was prepared with the aid of chitosan (cs) solution and then modified on a glassy carbon electrode (gce). gold nanoparticles (aunps) were then electrodeposited onto the surface of the gs-mwcnts film by cyclic voltammetry (cv) to immobilize the captured antibodies. aft ... | 2014 | 24632131 |
| acute epstein-barr virus pancreatitis with thoracic-abdominal abscess and portal compression. | 2014 | 24630949 | |
| epstein-barr virus-specific adoptive immunotherapy for progressive multiple sclerosis. | 2014 | 24622348 | |
| co-stimulatory blockade with belatacept in kidney transplantation. | calcineurin inhibitors (cnis) are the cornerstone of immunosuppression after transplantation but can exert negative effects on chronic allograft function and metabolic profile. belatacept, a selective co-stimulation blocker of t cells, is the first biologic agent approved for maintenance immunosuppression in kidney transplantation. studies reveal better preservation of glomerular filtration rate and improved metabolic end points with belatacept when compared to cnis. increased incidence of acute ... | 2014 | 24620724 |
| p53 expression is a strong marker of inferior survival in de novo diffuse large b-cell lymphoma and may have enhanced negative effect with myc coexpression: a single institutional clinicopathologic study. | to examine interactions among clinical factors and pathologic biomarkers in predicting the outcome of patients with diffuse large b-cell lymphoma (dlbcl) treated with rituximab-based immunochemotherapy. | 2014 | 24619762 |
| flow cytometric analysis of cerebrospinal fluid has low diagnostic yield in samples without atypical morphology or prior history of hematologic malignancy. | to identify pretest characteristics of cerebrospinal fluid (csf) specimens that will allow the rational use of flow cytometric analysis (fca) in the diagnosis of hematologic malignancy. | 2014 | 24619752 |
| genetic modification of cytotoxic t lymphocytes to express cytokine receptors. | adoptive transfer of tumor-infiltrating lymphocytes (til) or antigen-specific cytotoxic t lymphocytes (ctl) is safe and can be effective in cancer patients. achievement of clinical responses in these patients is associated with the in vivo expansion and persistence of the transferred t lymphocytes. for this reason, recombinant human interleukin-2 (il-2) is frequently used to support the in vivo survival of t lymphocytes infused into patients. however, il-2 also causes important side effects. thu ... | 2014 | 24619681 |
| [the visionary concept of "lymphoepithelioma" by a. schmincke in 1921. subsequent confusion over terminology and current approach to a solution]. | in 1921 alexander schmincke established the visionary concept of a clinically and histomorphologically defined carcinoma entity of different lymphoepithelial organs that he named "lymphoepithelioma". this nowadays mainly comprises non-keratinizing oropharyngeal carcinomas frequently associated with human papillomavirus (hpv) and non-keratinizing nasopharyngeal carcinomas mostly associated with epstein-barr virus (ebv). the term lymphoepithelioma was originally defined by a. schmincke and j. ewin ... | 2014 | 24619524 |
| the interplay between epstein-barr virus and b lymphocytes: implications for infection, immunity, and disease. | human b cells are the primary targets of epstein-barr virus (ebv) infection. in most cases, ebv infection is asymptomatic because of a highly effective host immune response, but some individuals develop self-limiting infectious mononucleosis, while others develop ebv-associated lymphoid or epithelial malignancies. the viral and immune factors that determine the outcome of infection are not understood. the ebv life cycle includes a lytic phase, culminating in the production of new viral particles ... | 2014 | 24619311 |
| from the radiologic pathology archives: mass lesions of the dura: beyond meningioma-radiologic-pathologic correlation. | meningioma is the most common mass involving the dura, making it number one in the differential diagnosis for any dural-based mass; however, a variety of other neoplastic and nonneoplastic lesions also involve the dura. knowledge of the dural anatomy can provide clues to the various processes that may involve this location. the neoplastic processes include both benign and malignant lesions such as hemangiopericytoma, lymphoma, solitary fibrous tumor, melanocytic lesions, epstein-barr virus-assoc ... | 2014 | 24617680 |
| [the entry of epstein-barr virus into b lymphocytes and epithelial cells during infection]. | epstein-barr virus (ebv) is a human herpesvirus associated with important human diseases, including infectious mononucleosis syndrome, malignant lymphoma, and nasopharyngeal carcinoma. the mechanism of ebv entry into host cells remains a subject of intensive research. after decades of study, researchers have identified several key proteins and different patterns of ebv intrusion into host cells. the viral surface glycoproteins, gp350/220, gp42, gb, gh, and gl, are involved in interactions with t ... | 2014 | 25272606 |
| [construction and immunological responses of recombinant adenovirus containing epstein-barr nuclear antigen 1 in mice]. | this study aimed to construct recombinant adenovirus expressing epstein-barr nuclear antigen 1 (ebna1) against nasopharyngeal carcinoma (npc). the c-terminal region fragment of the ebna1 gene of epstein-barr virus was amplified from the standard strain b95-8 by polymerase chain reaction (pcr). the gene fragment was inserted into the pdc316 shuttle plasmid using the ecori and bgiii restriction enzyme sites. the pdc316-ebna1 shuttle plasmid and pbhg helper plasmid were cotransfected into hek293 ce ... | 2014 | 25272599 |
| human dna tumor viruses generate alternative reading frame proteins through repeat sequence recoding. | kaposi's sarcoma-associated herpesvirus (kshv) and epstein-barr virus (ebv) are human dna tumor viruses that express nuclear antigens [latency-associated nuclear antigen 1 (lana1) and epstein-barr nuclear antigen 1 (ebna1)] necessary to maintain and replicate the viral genome. we report here that both lana1 and ebna1 undergo highly efficient +1/-2 programmed ribosomal frameshifting to generate previously undescribed alternative reading frame (arf) proteins in their repeat regions. ebna1(arf) enc ... | 2014 | 25271323 |
| spectrum of activity and mechanisms of resistance of various nucleoside derivatives against gammaherpesviruses. | the susceptibilities of gammaherpesviruses, including epstein-barr virus (ebv), kaposi's sarcoma-associated herpesvirus (kshv), and animal rhadinoviruses, to various nucleoside analogs was investigated in this work. besides examining the antiviral activities and modes of action of antivirals currently marketed for the treatment of alpha- and/or betaherpesvirus infections (including acyclovir, ganciclovir, penciclovir, foscarnet, and brivudin), we also investigated the structure-activity relation ... | 2014 | 25267682 |
| viral reprogramming of the daxx histone h3.3 chaperone during early epstein-barr virus infection. | host chromatin assembly can function as a barrier to viral infection. epstein-barr virus (ebv) establishes latent infection as chromatin-assembled episomes in which all but a few viral genes are transcriptionally silent. the factors that control chromatin assembly and guide transcription regulation during the establishment of latency are not well understood. here, we demonstrate that the ebv tegument protein bnrf1 binds the histone h3.3 chaperone daxx to modulate histone mobility and chromatin a ... | 2014 | 25275136 |
| visual diagnosis: 12-month-old boy with persistent rash and lymphadenopathy. | gianotti-crosti syndrome (gcs) is a self-limiting, papular or papulovesicular, symmetric, acral exanthem that typically presents subsequent to viral infection, bacterial infection, or immunization in a child 1 to 4 years old. the rash can persist for 2 to 10 weeks. recent infection with epstein-barr virus is the most common serologic finding in patients who have developed gcs. the diagnosis is often made after the child has been unsuccessfully treated for a more common cause of an acral rash (eg ... | 2014 | 25274975 |
| environmental exposures and the risk of multiple sclerosis investigated in a norwegian case-control study. | several environmental exposures, including infection with epstein-barr virus, low levels of vitamin d and smoking are established risk factors for multiple sclerosis (ms). also, high hygienic standard and infection with parasites have been proposed to influence ms risk. the aim of this study was to investigate the influence of various environmental exposures on ms risk in a norwegian cohort, focusing on factors during childhood related to the hygiene hypothesis. | 2014 | 25274070 |
| host genetic variants and gene expression patterns associated with epstein-barr virus copy number in lymphoblastoid cell lines. | lymphoblastoid cell lines (lcls) are commonly used in molecular genetics, supplying dna for the hapmap and 1000 genomes projects, used to test chemotherapeutic agents, and informing the basis of a number of population genetics studies of gene expression. the process of transforming human b cells into lcls requires the presence of epstein-barr virus (ebv), a double-stranded dna virus which through b-cell immortalisation maintains an episomal virus genome in every cell of an lcl at variable copy n ... | 2014 | 25290448 |
| primary esophageal burkitt's lymphoma: a rare case report and review of literature. | esophageal lymphoma is a rare condition, accounting for less than 1% of all gastrointestinal lymphomas. primary extra nodal esophageal lymphoma constitutes less than 0.2% cases of the total esophageal lymphomas. the definition of primary gi lymphoma has differed among authors. the etiology of the disease is unknown, with the role of epstein-barr virus being controversial. the common symptoms of patients with esophageal lymphoma include dysphasia, odynophagia, weight loss, chest pain or present a ... | 2014 | 25289138 |
| primary squamous cell carcinoma of the stomach: a case report. | pure squamous cell carcinoma (scc) of the stomach is rare and resembles scc arising elsewhere in the body. the pathogenesis of scc remains unclear and controversial. at present, <100 cases of primary scc of the stomach have been reported. the current study presents a case of scc of the stomach in a 61-year-old male. total gastrectomy was performed and a 7.0×6.7×4.5-cm tumor with a superiorly located ulcer was identified in the cardia. upon histological examination, a moderately-differentiated sc ... | 2014 | 25289093 |
| [a clinicopathologic and prognosis study of epstein-barr virus positive diffuse large b-cell lymphoma in west-southern china]. | to investigate the clinicopathologic features, immunophenotype, and the prognosis related factors of epstein-barr virus (ebv) positive diffuse large b-cell lymphoma (dlbcl) in west-southern china. | 2014 | 25286694 |
| [a case of crohn's disease following an infection by epstein-barr virus]. | infection by the epstein-barr virus (ebv) has been linked to the development of autoimmune diseases and recent studies have investigated its specific influence on inflammatory bowel diseases. this is a case report of a 20 year old patient who was diagnosed with crohn's disease following a prolonged manifestation of infectious mononucleosis. the current information regarding the association between ebv and the development of inflammatory bowel diseases is discussed. | 2014 | 25286632 |
| acetylation changes at lysine 5 of histone h4 associated with lytic gene promoters during reactivation of kaposi's sarcoma-associated herpesvirus. | kaposi's sarcoma-associated herpesvirus (kshv) is a pathogenic agent of kaposi's sarcoma, primary effusion lymphoma and multicentric castleman's disease in humans. similarly to other gammaherpesviruses such as epstein-barr virus (ebv) and herpesvirus saimiri (hvs), kshv displays two alternative life cycles, latent and lytic one. the transactivation from latency to the lytic phase is the result of transcriptional changes in the kshv genome caused by the replication and transcriptional activator ( ... | 2014 | 25283865 |
| management of lymph node metastases from an unknown primary site to the head and neck (review). | cancer of unknown primary site (cup) is an intriguing clinical phenomenon found in ~3-9% of all head and neck cancers. it has not yet been determined whether cup forms a distinct biological entity with specific genetic and phenotypic characteristics, or whether it is the clinical presentation of metastasis in patients with an undetected primary tumor and no visible clinical signs. the treatment of patients with cervical lymph node metastases from cup remains controversial, due to the lack of ran ... | 2014 | 25279174 |
| utilising proteomic approaches to understand oncogenic human herpesviruses (review). | the γ-herpesviruses epstein-barr virus and kaposi's sarcoma-associated herpesvirus are successful pathogens, each infecting a large proportion of the human population. these viruses persist for the life of the host and may each contribute to a number of malignancies, for which there are currently no cures. large-scale proteomic-based approaches provide an excellent means of increasing the collective understanding of the proteomes of these complex viruses and elucidating their numerous interactio ... | 2014 | 25279171 |
| epstein-barr virus nuclear antigen 3a promotes cellular proliferation by repression of the cyclin-dependent kinase inhibitor p21waf1/cip1. | latent infection by epstein-barr virus (ebv) is highly associated with the endemic form of burkitt lymphoma (ebl), which typically limits expression of ebv proteins to ebna-1 (latency i). interestingly, a subset of ebls maintain a variant program of ebv latency - wp-restricted latency (wp-r) - that includes expression of the ebna-3 proteins (3a, 3b and 3c), in addition to ebna-1. in xenograft assays, wp-r bl cell lines were notably more tumorigenic than their counterparts that maintain latency i ... | 2014 | 25275486 |
| mrna structural constraints on ebna1 synthesis impact on in vivo antigen presentation and early priming of cd8+ t cells. | recent studies have shown that virally encoded mrna sequences of genome maintenance proteins from herpesviruses contain clusters of unusual structural elements, g-quadruplexes, which modulate viral protein synthesis. destabilization of these g-quadruplexes can override the inhibitory effect on self-synthesis of these proteins. here we show that the purine-rich repetitive mrna sequence of epstein-barr virus encoded nuclear antigen 1 (ebna1) comprising g-quadruplex structures, limits both the pres ... | 2014 | 25299404 |