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immunotherapy from malignant disease. 1978348035
some examples of interactions between drugs in cancer chemotherapy.drug combinations in cancer treatment are widely utilized because they frequently result in better therapeutic activity than the single treatments. the mechanism(s) by which this can be achieved may reside in an enhanced chemotherapeutic effect or in reduced toxicity, it being difficult to dissociate the two aspects. to underline this difficulty, experimental studies will be reported. a first example illustrates the interaction between phenobarbital and cyclophosphamide. depending on the schedul ...1978348085
combination chemotherapy plus methanol extracted residue of bacillus calmette-guérin or corynebacterium parvum in stage iii lung cancer.seventy-six patients with stage iii bronchogenic carcinoma were treated with monthly adriamycin, cyclophosphamide, cis-dichlorodiammineplatinum(ii), and vincristine. in addition, they were randomized to receive either no immunotherapy, the methanol extracted residue of bacillus calmette-guérin (mer), or corynebacterium parvum (c. parvum). age, histology, extent of disease, prior therapy, and performance status were comparable in the three treatment groups. twelve patients (16%) died having recei ...1978350388
chemo-immunotherapy for unresectable bronchogenic carcinoma.seventy-nine patients with metastatic or unresectable bronchogenic carcinoma were treated with a regimen of combination chemotherapy which included methotrexate, oncovin (vincristine), cyclophosphamide, and adriamycin (moca), and were randomized to receive no additional therapy, immunotherapy with bacillus calmette-guérin, or immunotherapy with corynebacterium parvum (c. parvum). the response rate and estimated median survival time were 68% and 42 weeks in small cell carcinoma and 18% and 29 wee ...1978350397
immunity to transplantable carcinogen-induced fibrosarcomas in b2/b2 chickens. i. use of bacterial adjuvants in induction of immunity demonstrable in winn tests. 1978354799
combination chemoimmunotherapy for extensive non-oat cell lung cancer.in a prospective randomized trial, sc corynebacterium parvum (c. parvum) immunotherapy did not significantly affect the responses and survival of 49 non-oat cell lung cancer patients receiving isophosphamide and adriamycin chemotherapy. remissions (tumor regression greater than 50%) were seen in five of 23 patients receiving an intensive c. parvum schedule and in three of 26 patients receiving a nonintensive c. parvum schedule (22% versus 12%). median survival was 20 weeks for patients given int ...1978356968
the effect of intramural injection of immunotherapeutic agents on bladder histology and systemic humoral response.bacillus calmette-guerín (bcg), corynebacterium parvum, and various mycobacterium fragments were injected intramurally into mouse bladders and the resulting systemic humoral stimulation and local histologic reactions were evaluated. c. parvum and methanol extracted residue of bcg elicited significant immunostimulation without producing irreversible bladder damage. the severe histologic disruption caused by bcg could be reduced by the antituberculus drug isoniazed without abrogating the humoral s ...1978361626
[immuno-chemotherapy in patients with disseminated metastasizing stage iii melanoma. randomized study with methyl-ccnu versus c. parvum plus methyl-ccnu].34 patients with disseminated malignant melanoma (stage iii) were randomized to the following therapy groups: chemotherapy (meccnu, nsc 99441; 200 mg/m2, given orally every 8 weeks), or immuno-chemotherapy (1 mg corynebacterium parvum i.v., on days 1-4 + meccnu 200 mg/m2 on day 8, repeated every 7 weeks). total therapy response rate was 33%; total and partial remissions were achieved in 26% of the patients receiving chemotherapy, and in 40% under immuno-chemotherapy. interim life table analysis ...1978362293
multimodal immunotherapy of primary gastrointestinal tumors in rats. 1. histologic correlation.the effect of multimodal immunotherapy was studied in rats bearing primary gastrointestinal tumors induced by 1,2-dimethylhydrazine dihydrochloride. multimodal immune manipulation consisted of combinations of splenectomy, c. parvum, unblocking serum, unblocked lymphoid cells, and levamisole. such immunologic intervention resulted in significant inhibition of tumor growth, and their metastasis. ten of 10 untreated rats, 8 of 8 rats treated with splenectomy alone and 10 of 10 rats treated with nor ...1978363250
immunomodulation by corynebacterium parvum. 1. variable effects on anti-sheep erythrocyte antibody responses.corynebacterium parvum injected i.p. 1--16 days prior to i.p. antigen inoculation virtually abolished both igm and igg primary responses to 1 x 10(8) srbc. the suppression was significantly marked at antigen doses ranging from 1 x 10(6)--1 x 10(9) srbc but not at 5 x 10(9) srbc. as little as 56 microgram c. parvum caused a marked suppression of the response to 1 x 10(8) srbc. in secondary responses c. parvum given either one day before priming with 1 x 10(8) srbc or one day before secondary chal ...1978363603
[immunotherapy of malignant diseases. a way towards the goal?]. 1978305530
induction of interferon production in mouse spleen cell cultures by corynebacterium parvum. 1978307432
a role for t lymphocytes in tumour inhibition and enhancement caused by systemic administration of corynebacterium parvum. 1978308542
effect of corynebacterium parvum on human t-lymphocyte interferon production and t-lymphocyte proliferation in vitro. 1978309789
further observations on the inhibition of tumor growth by corynebacterium parvum with cyclophosphamide. v. comparison of the effects of tilorone hydrochloride, levamisole, methanol-soluble fraction of mycobacterium butyricum, bcg, and a nonviable aqueous ether extract of brucella abortus preparation in treatment of mice with tumors. 1978413929
organ distribution of technetium-99m-labeled corynebacterium parvum in normal and tumor-bearing mice. 1978618580
correlation of antitumor chemoimmunotherapy with serum inhibition of tumor cell destruction.the administration of cyclophosphamide and corynebacterium parvum in combination results in tumor growth inhibition greater than that resulting from the use of either agent alone. the precise mechanism(s) by which this chemoimmunotherapy combination results in a synergistic inhibiting effect is not known. the possibility was entertained that the tumor effect might be related to a greater decrease in serum-mediated interference with cellular cytotoxicity, i.e., "blocking" activity, by both agents ...1978618581
influence of immunotherapeutic agents on the progression of spontaneously arising, metastasizing rat mammary adenocarcinomas of varying immunogenicities. 1978618584
immune responses during administration of adriamycin and corynebacterium parvum. 1978618689
[immunological and immunotherapeutical aspects of cancer (author's transl)]. 1978619481
[finding of anaerobic bacteria in blood cultures].out of the blood cultures sent to the bacteriology laboratory of hospital del niño dif, during the period of one year, in 1.4% of samples, isolation of anaerobic bacteria was obtained. isolation was more frequent in infants under one year of age, but specially in newborns. the species most frequently found were propionibacterium acnes, bacteroides melaninogenicus and clostridium subterminale. the presence of this finding in blood cultures of infants is noted, but there is no purpose to establish ...1978619923
heterologous immunity between piroplasms and malaria parasites: the simultaneous elimination of plasmodium vinckei and babesia microti from the blood of doubly infected mice.mice which have recovered from infections with the avirulent piroplasm babesia microti are also resistant to challenge with the virulent malaria parasite plasmodium vinckei. in mice infected with p. vinckei before the peak of the b. microti infection the numbers of malaria parasites in the blood increase until that peak and are then eliminated at the same time as the piroplasms. in mice infected with p. vinckei at or after the peak there is no apparent multiplication and the malaria parasites be ...1978622306
regional variations of cutaneous propionibacteria.propionibacterium acnes, p. avidum, and p. granulosum were quantitatively measured in 50 young adults. the scalp, forehead, external auditory canal, alae nasi, anterior nares, groin, rectum, and antecubital and popliteal fossa were sampled. these represent various cutaneous microenvironments, differing in moisture, density of sweat, sebaceous glands, and extent of anaerobiosis. these studies show that the propionibacteria are ubiquitous on the skin, with p. acnes predominant in both prevalence a ...1978623473
treatment of malignant ascitic and pleural effusion with corynebacterium parvum.six patients with malignant effusions, five from adenocarcinomas and one from a melanoma, were treated by intrapleural or intraperitoneal corynebacterium parvum. in each case there was a definite reduction in the effusions with a significant decrease in the number of malignant cells; in most cases the effusions stopped completely. although none of the patients lived for more than a year after treatment, they were undoubtedly more comfortable, as they no longer required frequent paracentesis. in ...1978623981
use of bacteriophage typing to distinguish propionibacterium acne types i and ii.strains of serotypes i and ii of propionibacterium were compared for phage sensitivity. the two serotypes could be distinguished by using a typing set consisting of 16 bacteriophages at concentrations that demonstrated selective lysis of serotype i or ii bacterial strains. seven phage types were found; three were composed exclusively of serotype i, and four were exclusively composed of serotype ii organisms. generally, serotype i strains were more sensitive to phage lysis than were serotype ii s ...1978624772
antitumor activity of purified cell walls from corynebacterium parvum.cell walls (cw), containing peptidoglycan and carbohydrate, were prepared from corynebacterium parvum and tested for lymphoreticular stimulation and antitumor effects in cba-t6t6 mice. cw did not induce splenomegaly. peritoneal macrophages became cytostatic to rl leukemia cells in vitro after ip injection of cw or of peptidoglycan but not of carbohydrate; however, on a dry-weight basis the activity was low (less than 10%) compared with that of c. parvum. tumor outgrowth was significantly suppres ...1978625069
immunotherapy of an established rat mammary adenocarcinoma (13762a) with intratumor injection of corynebacterium parvum.we studied the effects of intratumor injection of corynebacterium parvum vaccine on the survival of 13762a tumor-bearing rats. vaccine injection of established (7-day-old) tumors produced dose-related prolongation of survival and cured some animals. although 30 to 40% of the vaccine-injected primary tumors regressed, recurrences and continued growth of metastases ultimately killed one-fourth of the regressors. rats given 1500 microgram of c. parvum intratumorally at 7 days, with or without later ...1978626972
enhancement by corynebacterium parvum of the normal and tumor tissue response to hyperthermia.the effect of corynebacterium parvum treatment on the response of tumor and normal tissue to hyperthermia (43.5 degrees) was studied. animals were c3hf/sed mice from our defined flora mouse colony. the time at hyperthermia that achieved control of one-half of methylcholanthrene-induced fibrosarcomas and the foot reaction were examined after treatment. c. parvum, if given 3 to 32 days before hyperthermia, enhanced the reaction to local hyperthermia of normal tissue. no enhancement was observed if ...1978626985
natural cell-mediated cytotoxicity in rats. ii. in vivo augmentation of nk-cell activity.natural cell-mediated cytotoxicity in rats as well as in mice has been shown to vary consistently with age, with peak levels detectable at 5-10 weeks. the levels of cell-mediated cytotoxicity against tumor cells could be augmented in strains of inbred rats with either high or low levels of natural reactivity, by ip injection of a variety of agents, including c. parvum, lcmv, krv, and poly i:c. the specificity of the augmented cytotoxicity appeared to be the same as the specificity of natural kil ...1978627428
corynebacterium parvum-induced resistance to a methylcholanthrene fibrosarcoma. 1978627989
modification of radiation responses of murine tumors by misonidazole (ro 07-0582), host immune capability, and corynebacterium parvum.the hypoxic cell sensitizer misonidazole (ro 07-0582),1-(2-nitro-1-imidazolyl)-3-methoxy-2-propanol, significantly enhanced the local control of the weakly immunogenic c3h mouse mammary carcinoma mdah-mca-4 (8-mm diameter) by single doses of radiation. the dose modification factor (dmf) was 2.33 when the drug was given ip to inbred c3hf/bu mice in a dose of 1 mg/g body weight 30 minutes before irradiation of the tumor. the dmf in a highly immunogenic 3-methylcholanthrene-induced c3h fibrosarcoma ...1978633396
immunotherapy of cancer with corynebacterium parvum. 1978637374
comparative studies of porphyrin production in propionibacterium acnes and propionibacterium granulosum.porphyrin production by propionibacterium acnes and that by propionibacterium granulosum were compared. porphyrin synthesized by both organisms was identified as coproporphyrin iii on the bases of absorption and fluorescence spectra and behavior on paper chromatography and thin-layer chromatography. quantitative, rather than qualitative, differences in production were found between these organisms. in general, p. granulosum produced significantly greater amounts (p less than 0.001) of porphyrin ...1978637914
studies with a spontaneous mouse tumor. i. growth in normal mice and response to corynebacterium parvum.growth of isogeneic transplants of a spontaneous murine adenocarcinoma, which is virtually devoid of tumour-specific transplantation antigens, is inhibited by i.v. injection of c. parvum 3 days after tumour inoculation, or by mixing a small dose of c. parvum with the tumour inoculum. moreover, the therapeutic effect of cyclophosphamide, followed by i.v. or i.p. injection of c. parvum 5 days later, on established transplants of the same tumour is greater than that of cyclophosphamide alone. these ...1978638014
endophthalmitis caused by propionibacterium acnes.we treated a man who developed endopthalmitis six weeks after a seemingly minor injury. cultures were positive for propionibacterium acnes, an anerobic, gram-positive rod that is a normal inhabitant of the conjunctiva but is rarely a cause of endophthalmitis. the patient underwent vitrectomy and lensectomy with intravitreal injection of antibiotics followed by systemic cephalothin and prednisone. clinical and visual improvement was rapid.1978638845
phase i studies of c. parvum given intravenously: effects of dexamethasone on its biologic and toxic properties.three biologic effects were clearly associated with c. parvum infusions: a) granulocytosis with lymphomonocytopenia, b) increase in responsiveness to phytohemmagglutinin and c) increase of specific antibodies to c. parvum antigens. addition of dexamethasone moderately altered the kinetics of leukocyte changes without affecting other properties. side effects after intravenous administration of c. parvum (2.5 mg/m2) consisted primarily of chills and fever which lasted for periods of 6-24 hours. s ...1978638994
thymoindependent antigentic stimulation in nude mice: response to polyvinylpyrrolidone and adjuvant effects of corynebacterium parvum and lh1.the humoral thymoindependent response to polyvinylpyrrolidone (pvp) measured by the farr test, was not different in athymic nude and phenotypically normal mice. in athymic and normal mice, this response was significantly increased by cornebacterium parvum administered at the time of immunization. a recently synthetized compound, lh1 (3alpha-n-[2 aminoethanol]-amino 5-alpha-pregnane-20-one) was, however, a better immunostimulant of the anti-pvp response in athymic mice.1978640744
effects of amputation and corynebacterium parvum on tumour metastases in mice.the effects of operation (lower-limb amputation) on the growth of the lewis lung tumour and its metastases were studied. the role of c. parvum in counteracting these effects was investigated. anaesthesia alone or with amputation did not affect primary tumour growth. c. parvum depressed this growth. anaesthesia did not affect the number of pulmonary metastases, but amputation caused a significant increase. c. parvum inhibited metastases and completely counteracted the effects of operation on them ...1978646927
corynebacterium parvum enhances colonic cancer in dimethylhydrazine-treated rats. 1978646934
decreased hepatic drug demethylation in patients receiving chemo-immunotherapy.the effect of immunotherapy and chemotherapy on hepatic n-demethylation of aminopyrine was studied by means of the aminopyrine breath test (abt) in 32 patients with cancer. the aminopyrine breath test (abt) was decreased in 3 of 11 patients (27.3%) receiving intradermal bcg (+/- dtic) at a dose of 3 x 10(7) viable organisms. one of 4 (25%) patients receiving intradermal bcg (+/- dtic) at 3 x 10(8) viable organisms per dose developed an altered abt. changes were not seen in patients receiving aer ...1978647621
monocyte function in patients with solid neoplasms during immunotherapy with corynebacterium parvum.the present studies were performed in order to evaluate monocyte function in patients with solid neoplasms before and after administration of c. parvum. the results demonstrate that monocytes from cancer patients display increased numbers of c3 and fc receptor sites after administration of c. parvum. it is concluded that characterization of monocyte receptor activity may be helpful in monitoring the effects of immunotherapy in the immune system.1978647625
induction of spleen cell growth and dna polymerase activity by corynebacterium parvum.corynebacterium parvum induces rapid proliferation of spleen cells with concomitant rapid increases in dna synthesis as measured by [3h]thymidine uptake and increase in dna polymerase activity. cell number increased exponentially over 10 days. dna polymerase activity increased 8-fold after c. parvum stimulation. the rapidity of response indicated a population response to the stimulus, and the data are consistent with a direct stimulation of spleen cell proliferation by c. parvum.1978647675
effect of aerobic and anaerobic corynebacteria on reaginic antibody response in mice. 1978661628
radiation-induced inhibition of splenocyte locomotion and its protection by c. parvum. 1978663069
prospective randomized evaluation of the role of limb-sparing surgery, radiation therapy, and adjuvant chemoimmunotherapy in the treatment of adult soft-tissue sarcomas. 1978663826
nephrotoxicity from cancer immunotherapy.because systemic intravenous immunotherapy with corynebacterium parvum is an effective immunopotentiating and immunotherapeutic agent in animals, clinical studies of this agent have been undertaken. toxicities in man have been noted, but most are treated symptomatically. three patients with metastatic melanoma developed oliguria, edema, diffuse bilateral pulmonary infiltrates, azotemia, hypoalbuminemia and hypocomplementemia, while receiving intravenous c. parvum therapy. all had renal biopsies ...1978666183
immunity to transplantable carcinogen-induced fibrosarcomas in b2/b2 chickens. iii. tumor growth inhibition by local delayed hypersensitivity reactions to unrelated antigens.delayed hypersensitivity (dh) reaction to human ig, corynebacterium parvum or allogeneic cells at the site of tumor cell injection, suppressed the fibrosarcoma (scfs) growth in chickens. spleen cells of sc chickens sensitized to human ig or c. parvum suppressed scfs growth when adoptively transferred with tumor cells, but only when the sensitizing antigen was present locally. this suppression did not occur in irradiated recipients, scfs i cells injected into wattles of chickens immune to the tum ...1978668800
response of malignant melanoma to plasma exchange, surgical debulking, and corynebacterium parvum.a 48 year old man with extensive cutaneous and subcutaneous metastatic malignant melanoma responded to treatment by repeated plasma exchanges, partial surgical debulking of tumor masses, and intravenous corynebacterium parvum. circulating immune complexes were measured by the serum c1q binding method. tumor regression coincided with serum c1q binding reduction to normal levels. clinical relapse was preceeded by recurrent elevation of serum c1q binding activity.1978669835
effects of corynebacterium parvum and cortisone on the primary lewis tumour and its metastases.the effects of corynebacterium parvum and cortisone acetate (ca) on the primary lewis lung carcinoma and its pulmonary metastases were investigated. c. parvum given iv either on the same day or 7 days after tumour inoculation, reduced primary tumour growth, while 2.5 mg ca (high-dose) given sc 4 and 11 days after tumour, alone or in combination with c. parvum, administered on day 0, reduced primary tumour growth to the same extent as c. pravum alone. high-dose ca given on days 2 and 6 had no eff ...1978669856
induction of interferon in mice injected with heat-killed corynebacterium anaerobium. 1978671815
electrophoretic protein patterns and enzyme mobilities in anaerobic coryneforms.the soluble protein patterns and electrophoretic mobilities of malate and succinate dehydrogenases and catalase have been examined in 25 strains of propionibacterium acnes, p. granulosum, and p. avidum. a distinctive protein pattern for each species was found, and it was possible also to distinguish the serotypes within p. acnes and p. avidum. strains of p. acnes, p. granulosum, and p. avidum could be differentiated by the mobilities of their malate dehydrogenases. catalase activity was detected ...1978677876
anaerobic flora of the normal human conjunctival sac.specimens from the conjunctival sacs of 92 healthy eyes were cultured on two separate occasions to determine the presence or absence of a persistent anaerobic flora. aerobic bacteria and fungi were also studied for comparison. of the 184 eye cultures, 112 (60.9%) contained at least one microorganism. obligate anaerobes were recovered from 51.6% (95/184) of the cultures. propionibacterium acnes, the predominant anaerobe encountered, was present in 49.5% (91/184) of the eyes. aerobic and facultati ...1978678185
coagulation and fibrinolysis during the infusion of corynebacterium parvum in man. 1978678428
effect of corynebacterium parvum on the proliferative rate of granulocyte-macrophage progenitor cells and the toxicity of chemotherapy.we have studied the interaction of corynebacterium parvum and a variety of cell cycle-specific and cell cycle-nonspecific chemotherapeutic agents on granulocyte-macrophage progenitor cells [colony-forming units culture (cfu-c)] in c57bl/6 mice. in vitro tritiated thymidine suicide studies showed an increased rate of proliferation of bone marrow cfu-c 24 hr after c. parvum injection. in vivo toxicity of cell cycle-specific agents but not of cell cycle-nonspecific agents for bone marrow cfu-c was ...1978679169
comparison of the inhibition of tumor growth following local or systemic administration of corynebacterium parvum or other immunostimulating agents with or without cyclophosphamide. 1978679170
rate of tumour inhibition by activated macrophages in vitro. 1978679868
cytotoxic activity of human blood monocytes against cultured breast cancer cells.cytotoxic activity of blood monocytes from 19 healthy individuals was examined in vitro against the cultured floating cells of human breast cancer origin. target tumor cells inoculated on monocyte cultures and maintained for 5 days were reduced in number, compared with the control cultues of tumor cells alone. increased cytotoxicity of the monocytes was noted after in vitro activation by heat-killed corynebacterium liquefaciens (propionibacterium acnes). c. liquefaciens of the same dose as used ...1978680464
interferon production and lymphocyte stimulation in human leucocyte cultures stimulated by corynebacterium parvum.killed c. parvum organisms stimulated a lymphoproliferative response in human peripheral leucocyte cultures of both adult and cord blood origin. they also induced high titres of interferon in cultures of adult leucocytes, but there was no correlation between the degree of lymphocyte stimulation and of interferon production. a considerable variability between donors was seen in both assays. the amount of interferon produced in c. parvum-stimulated cultures was considerably higher than that stimul ...1978688696
in vitro activity of tiamulin (81.723 hfu), a new pleuromulin derivative, against clinically significant anaerobes.the susceptibility of more than 40 strains of gram-negative and gram-positive anaerobes to tiamulin (sandoz 81.723 hfu), a new pleuromulin (pleuromutilin) derivative, was determined by broth dilution and agar dilution tests. the influences of density of the inoculum upon mics was studied by a specially designed pour plate-technique. bacteroides fragilis, b. vulgatus, b. splanchnicus, b. oralis, b. asaccharolyticus, b. melaninogenicus, fusobacterium fusiforme (f. nucleatum), sphaerophorus necroph ...1978690009
preliminary observations on the use of corynebacterium parvum in patients with primary intracranial tumors: effect on intracranial pressure.it has been observed that patients with metastatic brain lesions developed neurologic symptoms when given corynebacterium parvum. to obtain more information in patients with intracranial mass lesions, intracranial pressures (icp) were measured or observed in six patients undergoing c. parvum therapy. all patients except two (one previously shunted, one recently operated) demonstrated a profound increase in icp. it is presumed that either edema is formed within brain and tumor tissue (inasmuch as ...1978692136
immunoproliferative alterations in lymphoid tissues and liver in mice stimulated with corynebacterium parvum.morphological alterations in the spleen, liver, lymph nodes, thymus, bone marrow and blood were studied in dba and balb/c mice treated with corynebacterium parvum. the spleen lymph nodes and liver increased in size and weight, whereas thymus showed decrease in weight compared to the control group. a marked, early proliferation of monocytes in the bone marrow preceded infiltrations by macrophages in lymph nodes, spleen and liver. these infiltrations were closely related to the vascular structures ...1978696333
failure of preoperative c. parvum vaccine to modify secondary disease following excision of two non-immunogenic murine carcinomas.sadler and castro (1976) reported that a single dose of c. parvum vaccine given i.p. or i.v. to mice 4 days before excision of subcutaneous transplants of lewis lung carcinoma significantly reduced the incidence of lung metastases in the operated mice. in similarly designed experiments, using 2 different carcinomas of spontaneous origin in our own inbred mouse colonies, we were unable to demonstrate any influence of c. parvum vaccine on the incidence or latent period of secondary disease in oper ...1978698036
bacteriologic examination of autologous blood. 1978705401
a preliminary study of intralesional, intralymph node, intravenous and intraperitoneal corynebacterium parvum treatments in patients with advanced cancer.twenty-one patients with squamous cell carcinoma of oral cavity and/or cervical lymph node and four patients with soft tissue sarcomas were given intralesional (2-4 mg/m2) and intralymph node (2-4 mg/m2) c. parvum injections followed by 5 intravenous (2-4 mg/m2) c. parvum treatments and conventional therapies. seven patients with stage iii ovarian carcinomas were given intraperitoneal (2-4 mg/m2) c. parvum injections followed by conventional therapies. the local and systemic effects of the c. pa ...1978709538
combined radiotherapy and corynebacterium parvum treatment of rat tumors with different immunogenicity. 1978711536
lysozyme levels and macrophage content of tumor tissue in c3h mice bearing fibrosarcoma transplants treated by radiation and corynebacterium parvum. 1978711553
bacteriological investigation on biopsy specimens from patients with sarcoidosis.biopsy specimens, mostly lymph nodes, removed under aseptic conditions, were emulsified and the homogenate was inoculated in various media, which were incubated aerobically or anaerobically. only propionibacterium acnes was isolated in high incidence and the highest concentration of bacteria was 6.5 x 10(5) per g tissue: 28 and 31 out of 40 lymph nodes were positive on solid and on liquid media, respectively. p.acnes was also isolated from control non-sarcoidosis lymph nodes: 4 and 8 out of 14 w ...1978713130
characterization of propionibacterium acnes isolated from biopsy specimens obtained from patients with sarcoidosis. 1978713132
pigment vs cholesterol cholelithiasis: bacteriology of gallbladder stone, bile, and tissue correlated with biliary lipid analysis. 1978717347
toxicity manifestations following intravenous corynebacterium parvum administration to patients with ovarian and cervical carcinoma.manifestations of clinical toxicity were evaluated following 341 courses of intravenous corynebacterium parvum adjuvant immunotherapy in patients with ovarian and cervical carcinoma. most patients exhibited symptoms of minor toxicity, which decreased in intensity as subsequent courses of therapy were administered. temperature elevations to 38.5 degrees c. were the most objectively measured signs of toxicity but temperature elevations greater than 38.5 degrees c. occurred following only 20.5 per ...1978717456
destruction of regional lymph node metastases of rat mammary adenocarcinoma 13762a by treatment with corynebacterium parvum.intratumoral administration of corynebacterium parvum to 13762a tumor-bearing rats on day 7 of tumor growth, followed by primary tumor excision on day 20, regularly cured about 40% of the animals and significantly prolonged survival in the remainder. rats treated by surgery alone on either day 7 or day 20 died with metastases to axillary lymph nodes and lungs. tumor was established in axillary lymph nodes by day 7. therefore, intratumoral injection of c. parvum on day 7 destroyed metastases alre ...1978719637
positive 67ga-citrate scans in patients receiving corynebacterium parvum.gallium-67 citrate imaging for the staging of lymphomas was performed in three patients receiving corynebacterium parvum (c. parvum) immunotherapy. unexpected uptake at the site of c. parvum injections was identified and although the mechanism of localization is not determined by this study, similarities between c. parvum's known actions and the postulated mechanism of 67ga-citrate localization are compared.1978719980
immune prophylaxis of experimental cancer by corynebacterium parvum.fractionated administration of c.p. i.v. in mice at risk from sarcomas after injection of 0.2 mg mca leads to a significant prolongation of the period of latency under certain circumstances. experimental groups which have received the immune stimulator for 6 weeks immediately after the cancerogenic factor show the best results. after tumour manifestation there is no perceptible preventive effect of c.p.1978720440
further observations on the inhibition of tumor growth by corynebacterium parvum with cyclophosphamide--viii. 1978721660
electron capture gas-liquid chromatographic study of metabolites produced by some arthritic transudate-associated organisms in vitro and in vivo in rabbit models.computerized, frequency-pulsed, modulated electron capture gas-liquid chromatography was used to study the acid metabolites produced in vitro in fetal calf serum and in vivo in an animal chamber model. several strains of diplostreptococcus agalactiae, propionibacterium acnes, staphylococcus aureus, and streptococcus serogroups a, b, and g were studied. all of these organisms have been reported to be associated with arthritic transudates in humans. metabolites were detected by this method from de ...1978721944
differential susceptibility of propionibacterium acnes, p. granulosum and p. avidum to free fatty acids.the susceptibility of 98 propionibacterium acnes, p. granulosum and p. avidum strains isolated from acne cases and appropriate reference strains to decanoic, dodecanoic, octadeca-9,12 dienoic, and octadeca-9,12,15 trienoic acids was investigated using minimal inhibitory concentration estimation by an agar dilution techique. the tested acids showed their relative antibacterial activity in the following order: c18:3 delta 9,12,15 greater than c18:2 delta 9,12 greater than c12:0 greater than c10:0 ...1978722112
propionicins, bacteriocins produced by propionibacterium avidum.one hundred strains of propionibacterium acnes, granulosum and avidum were tested for susceptibility toward bacteriocins produced extracellularly by eight strains of propionibacterium avidum. some bacteriocin-producing strains were inhibitory for all strains tested. a name propionicins, is proposed for bacteriocins produced by p. avidum.1978726736
effect of glucan and other adjuvants on the clearance of radiolabeled tumor cells from mouse lungs.the iv injection of two forms of glucan (diluzio and yamamura), corynebacterium parvum, or bacillus calmette-guérin (bcg) caused a significant increase in the rate and extent of clearance of subsequently injected radiolabeled t1699 carcinoma cells from the lungs of syngeneic dba2 mice. dose-response curves were obtained for each agent, the relative rates of clearance of radiolabeled cells were established, and preliminary sequential comparative studies were undertaken. the optimum dose for c. pa ...1978728905
comparative effects of corynebacterium parvum, brucella abortus extract, bacillus calmette-guérin, glucan, levamisole, and tilorone with or without cyclophosphamide on tumor growth, macrophage production, and macrophage cytotoxicity in a murine mammary tumor model.in this laboratory, it has been repeatedly demonstrated (using a murine mammary tumor model) that the combination of cyclophosphamide (cy) and corynebacterium parvum (cp) is more effective than either agent alone in the control of tumor growth. this paper presents information obtained in our model comparing findings on the effects of cp with a brucella abortus extract (bru-pel; bp) and glucan (gl) on tumor growth. in addition, the influence of those agents as well as bacillus calmette-guérin, ti ...1978728912
effect of topical application of dexamethasone on propionibacteria in the pilosebaceous duct.a preparation of dexamethasone 0.02% in eutanol g (n octyldodecanol) was applied once daily for three weeks, to the right side of the forehead of 25 male healthy test subjects. eutanol g without dexamethasone was applied in the same way to the left side of the forehead. before and at the end of the treatment period bacteria were removed from the pilo-sebaceous ducts by the method of holland et al. [8]. bacteria that grew under anaerobic conditions were evaluated quantitatively. dexamethasone ind ...1978729607
saprophytic bacterial flora in the sebaceous gland infundibulum in diabetes mellitus. 1978736608
propionibacteria as a cause of shunt and postneurosurgical infections.propionibacterium acnes was isolated from postoperative specimens from nine neurosurgical patients. the role of p. acnes in postneurosurgical infection is discussed.1978739055
studies on putative adult worm-derived vaccines and adjuvants for protection against schistosoma mansoni infection in mice.intraperitoneal transfer of viable adult worms of schistosoma mansoni did not confer protection against a challenge infection to recipient mice. antigens of schistosome origin were evaluated for their ability, with and without concomitantly administered nonspecific adjuvants, to stimulate protective immunity against s. mansoni. freshly perfused ground worms or a putative membrane antigen extracted with 0.5 m kc1 from adult worms, when injected together with corynebacterium parvum (or in a single ...1978739318
purification and properties of a bacteriocin-like substance (acnecin) of oral propionibacterium acnes.propionibacterium acnes cn-8, isolated from human dental plaque, was grown in a liquid medium, and its bacteriocin-like substance (acnecin) was extracted from the cells by ultrasonic treatment. acnecin was purified to a homogeneous state with recovery of 47%. specific activity increased 72-fold in comparison with the crude extract. the properties of acnecin were as follows. (i) acnecin may consist of five subunits with a molecular weight of about 12,000. (ii) its isoelectric point was 5.5. (iii) ...1978742876
a bladder tumor model response to immunotherapy.the author presented results of bcg and corynebacterium parvum treatment of the transplantable mouse fanft bladder tumor carried in the host's leg. a comparison was made of the results of treatment with bcg alone and c. parvum alone or either used in conjunction with cytoxan upon effectiveness in increasing animal survival and retarding tumor growth.1978748789
local corynebacterium parvum therapy in early breast cancer: a pilot study. 1978750126
studies on resistance to marek's disease tumorigenesis: effect of immune stimulation, tumour-cell vaccines, and herpesvirus of turkeys on tumour immunity. 1978751899
bacteriocin (acnecin) activity of oral propionibacterium acnes. 1978291496
altered toxicity of 5-fluorouracil following treatment with corynebacterium parvum.recent studies have demonstrated that systemic corynebacterium parvum increases serum granulocyte-macrophage colony-stimulating factor and stimulates the proliferation of granulocyte-macrophage progenitor cells. it was hypothesized that more rapid cycling of granulocyte-macrophage progenitor cells would render the cells more sensitive to a cell cycle-specific chemotherapeutic agent. the colony-forming ability of bone marrow granulocyte-macrophage progenitor cells was assayed in vitro with soft a ...1978304762
[the so-called adjuvant corynebacterium parvum]. 1978304802
colony stimulating and inhibiting activities in mouse serum after corynebacterium parvum-endotoxin treatment. 1978304892
suppression of rat t cell proliferation by corynebacterium parvum: t cell requirement for induction. 1978304893
mechanism of nonspecific macrophage-mediated cytotoxicity: evidence for lack of dependence upon oxygen.peritoneal macrophages elicited in c3h/hj mice by the i.p. injection of corynebacterium parvum were cytotoxic to allogeneic virus-transformed fibroblasts in vitro. cytotoxicity was demonstrated in a morphologic (plaque) assay, and quantitated by measuring macrophage-mediated inhibition of incorporation of 3h-thymidine by the target cells. the cytotoxic effect was well established by 6 hr of macrophage-fibroblast interaction, and was retained in cultures from which the supernatant was removed bef ...1978340584
suppression of natural killer cell cytotoxicity by splenocytes from corynebacterium parvum-injected, bone marrow-tolerant, and infant mice.natural killer (nk) cell cytotoxicity to yac-1 lymphoma was investigated in mice tolerant to bone marrow grafts (bm-tolerant), corynebacterium parvum- (c. parvum) treated mice, and infant mice. also the comparison was made between the nk cell and the hemopoietic-resistance effector (hr-e) cells. it was found that the bm-tolerant mice and c. parvum-treated mice showed either no or markedly decreased nk cell cytotoxicity. these mice were also nonresponders to bone marrow grafts in vivo. the lack o ...1978342602
antitumor activity of corynebacterium parvum. 1978343523
liver abscess in normal children with fever of unknown origin. 1978263854
tumor immunology of experimental osteosarcoma.a spontaneous ap positive c3h murine os was used to determine the effects of various treatment modalities. ap served as a useful circulating biomarker of the in vivo tumor growth. in animals whose tumor was amputated, the elevation of the marker indicated the presence of pulmonary metastases. it was used to establish the time of recurrence after a partially effective chemotherapy or combination modality. in this model, when the neoplasm was surgically excised at 10 days posttransplantation, 70-- ...1978278687
effect of corynebacterium parvum on tumor growth in the central nervous system of mice. 1978278860
propionibacterium acnes-mediated humoral immune responses to tumor-specific antigens on rat liver cells transformed in vitro by chemical carcinogens.effects of propionibacterium acnes on production of antibodies against tumor-specific membrane antigens were investigated in syngeneic inbred bd iv and bd vi rats. bd rat liver cell lines transformed in vitro by chemical carcinogens were used as target cells for tumor-specific antigens. by membrane immunofluorescence, antibodies against these rat liver cell lines were detected in syngeneic bd rat sera. antibodies were produced in syngeneic rats under the adjuvant effect of heat-killed p. acnes o ...1978281560
effects of corynebacterium parvum on murine myeloid leukaemia.the effects of c. parvum on rfm/un myeloid leukaemia were studied. mice inoculated with 7.0 mg but not 0.7 mg c. parvum i.p. survived significantly longer than untreated leukaemic mice (p less than 0.001). administration of silica abrogated the effects of c. parvum, whilst polyvinyl pyridine-n-oxide prevented the inhibitory effects of silica. these studies demonstrate that a single large dose of c. parvum, either before or after leukaemic-cell passage, can significantly prolong the survival of r ...1978217398
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