Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| structures of withanosides i, ii, iii, iv, v, vi, and vii, new withanolide glycosides, from the roots of indian withania somnifera dunal. and inhibitory activity for tachyphylaxis to clonidine in isolated guinea-pig ileum. | seven new withanolide glycosides called withanosides i, ii, iii, iv, v, vi, and vii were isolated from an indian natural medicine, ashwagandha, the roots of indian withania somnifera dunal. (solanaceae), together with four known compounds, withaferin a, 5 alpha,20 alpha(f)(r)-dihydroxy-6 alpha,7 alpha-epoxy-1-oxowitha-2,24-dienolide, physagulin d, and coagulin q. the structures of withanosides i, ii, iii, iv, v, vi, and vii were determined based on chemical and physicochemical evidence. principa ... | 2001 | 11408168 |
| reversal of paclitaxel induced neutropenia by withania somnifera in mice. | the effect of aqueous extract of withania somnifera (l. solanaceae) was studied against paclitaxel induced neutropenia in mice. after paclitaxel 1 mg/kg, i.v. administration significant fall in total wbc and absolute neutrophil count was observed on day 3 and day 5. w. somnifera (200 mg/kg, p.o.) per se produced significant increase in neutrophil counts. w. somnifera (200 mg/kg, p.o.) when administered for 4 days before paclitaxel treatment and continued for 12 days caused significant reversal o ... | 2001 | 11480235 |
| adaptogenic activity of a glyco-peptido-lipid fraction from the alcoholic extract of trichopus zeylanicus gaertn. | a glyco-peptido lipid fraction ("af") from the alcoholic extract of trichopus zeylanicus gaertn. was evaluated for putative antistress activity in a battery of tests. "af" exhibited significant antistress activity in dose dependent manner in all the parameters studied, against the different stresses use to induce non-specific stress. ashwagandha, the commercial extract of withania somnifera roots was used as control: a preliminary acute toxicity study in mice showed a good margin of safety, as t ... | 2001 | 11515718 |
| neuroprotective effects of withania somnifera dunn. in hippocampal sub-regions of female albino rat. | the neuroprotective effects of w. somnifera were studied on stressed adult female swiss albino rats. experimental rats were subjected to immobilization stress for 14 h and were treated with a root powder extract of w. somnifera available as stresscom capsules (dabur india ltd). control rats were maintained in completely, non stressed conditions. thionin stained serial coronal sections (7 microm) of brain passing through the hippocampal region of stressed rats (e(1) group) demonstrated 85% degene ... | 2001 | 11536389 |
| microorganisms asssociated with withania somnifera leaves. | microorganisms including bacteria, actinomycetes and fungi were recovered from the leaves of withania somnifera, which were collected from two altitudinal ranges (0-300 m and 1700-2000 m) in the asir region, saudi arabia. types and numbers of microorganisms varied according to the altitude and the month of collection. the number of microorganisms was higher on old leaves than that on young ones in most cases. low altitude exhibited more microorganisms than high altitude. the relationship between ... | 2001 | 11770847 |
| clastogenic effects of dietary supplement--spirulina alga, and some medicinal plant products from boswellia serrata, withania somnifera on mice. | pretreatment of aqueous extracts of zyrulina (spirulina), aswagandha (withania) and nopane (boswellia) on colchicine induced chromosome damage showed weakness of clastogenic activity in swiss albino mice. none of the treatments increased significantly the number of chromosome aberrations. | 2001 | 11883518 |
| anti-oxidant effect of withania somnifera glycowithanolides in chronic footshock stress-induced perturbations of oxidative free radical scavenging enzymes and lipid peroxidation in rat frontal cortex and striatum. | the antioxidant activity of withania somnifera (ws) glycowithanolides was assessed in chronic footshock stress induced changes in rat brain frontal cortex and striatum. the stress procedure, given once daily for 21 days, induced an increase in superoxide dismutase (sod) and lipid peroxidation (lpo) activity, with concomitant decrease in catalase (cat) and glutathione peroxidase (gpx) activities in both the brain regions. ws glycowithanolides (wsg), administered orally 1 h prior to the stress pro ... | 2001 | 11137343 |
| effect of certain plant extracts on alpha-amylase activity. | ethanolic extracts of punica granatum, mangifera indica, boerhaavia diffusa, embelia ribes, phyllanthus maderaspatensis, and withania somnifera, were tested for their effect on alpha-amylase activity (in vitro). p. granatum and m. indica were found to exhibit interesting alpha-amylase inhibitory activity. | 2001 | 11223231 |
| the effect of aqueous extracts of cynomorium coccineum and withania somnifera on testicular development in immature wistar rats. | the effect of lyophilized aqueous extract of cynomorium coccineum and withania somnifera on testicular development and on serum levels of testosterone, icsh and fsh was studied in immature male wistar rats. there was a notable increase in testicular weight of animals treated with both extracts. histological examination revealed an apparent increase in the diameter of seminiferous tubules and the number of seminiferous tubular cell layers in the testes of treated rats as compared with control one ... | 2001 | 11282435 |
| indian medicinal plants as antiradicals and dna cleavage protectors. | celastrus paniculatus l. (celastraceae) (cp), picrorhiza kurroa l. (scrophulariaceae) (pk) and withania somnifera l. (solanaceae) (ws) are indian medicinal plants having a remarkable reputation, as a factor of health care, among the indigenous medical practitioners. the plants exhibit varying degrees of therapeutic value some of which useful in the treatment of cognitive dysfunction, epilepsy, insomnia, rheumatism, gout, dyspepsia. in this work, we have investigated the free radical scavenging c ... | 2001 | 11315755 |
| calystegine distribution in some solanaceous species. | the distribution of eight calystegines (a(3), a(5), b(1), b(2), b(3), b(4), c(1) and n(1)) and their content was investigated by gas chromatography coupled to mass spectrometry (gc-ms) in datura metel, atropa belladonna, hyoscyamus albus, mandragora autumnalis, solanum sodomaeum, withania somnifera, withania frutescens and brunfelsia nitida. the most frequently encountered calystegines were a(3), b(1), b(2) and b(3), while distribution of n(1) and c(1) was more limited. in all the investigated s ... | 2001 | 11557078 |
| stress induced neuron degeneration and protective effects of semecarpus anacardium linn. and withania somnifera dunn. in hippocampus of albino rats: an ultrastructural study. | effects of herbal formulations were studied on hippocampal neuron cell bodies. study was carried out in adult swiss albino rats. experimental rats (e) were divided into three groups. group e1 rats were given immobilization stress for 14 hr/day for 30 days. rats in e2 and e3 group were given daily single dose (40 mg/kg/body wt.) of alcoholic extract of s. anacardium and w. somnifera. after 1 hr giving the plant extract, the rats were subjected to stress. treatment continued for 14 hr for 30 days. ... | 2000 | 11324152 |
| anxiolytic-antidepressant activity of withania somnifera glycowithanolides: an experimental study. | the roots of withania somnifera (ws) are used extensively in ayurveda, the classical indian system of medicine, and ws is categorized as a rasayana, which are used to promote physical and mental health, to provide defence against disease and adverse environmental factors and to arrest the aging process. ws has been used to stabilize mood in patients with behavioural disturbances. the present study investigated the anxiolytic and antidepressant actions of the bioactive glycowithanolides (wsg), is ... | 2000 | 11194174 |
| curative property of withania somnifera dunal root in the context of carbendazim-induced histopathological changes in the liver and kidney of rat. | the liver and kidney of rat underwent severe histopathological lesions when treated with a single bolus dose of carbendazim, a fungicide, particularly affecting the hepatocytes and the renal corpuscles, respectively. the effects appear to be manifestations of the microtubule-disrupting activity of carbendazim. treatment of carbendazim-treated rats with the powder of tuberous root of withania somnifera (ashwagandha) for 48 days resulted in complete cure of these organs. the results indicate that ... | 2000 | 11194179 |
| adaptogenic activity of siotone, a polyherbal formulation of ayurvedic rasayanas. | siotone (st) is a herbal formulation comprising of withania somnifera, ocimum sanctum, asparagus racemosus, tribulus terristris and shilajit, all of which are classified in ayurveda as rasayanas which are reputed to promote physical and mental health, improve defence mechanisms of the body and enhance longevity. these attributes are similar to the modern concept of adaptogenic agents, which are, known to afford protection of the human physiological system against diverse stressors. the present s ... | 2000 | 11218827 |
| adrenocorticosterone alterations in male, albino mice treated with trichopus zeylanicus, withania somnifera and panax ginseng preparations. | the levels of corticosterone were estimated by the hplc method in the adrenal glands of stressed (5 h constant swimming) male albino mice treated with trichopus zeylanicus, withania somnifera and panax ginseng preparations and compared with non-treated stressed and normal controls. the treatments increased the corticosterone levels in all the groups. the physical endurance (increased survival time) of swimming mice also increased in all the treated groups, except in the group treated with withan ... | 2000 | 10685111 |
| adaptogenic and cardioprotective action of ashwagandha in rats and frogs. | pharmacological and metabolic effects of ashwagandha (withania somnifera l. (solanaceae)) used in ayurveda as a herbal tonic and health food were studied. ashwagandha was shown to increase swimming time in rats in physical working capacity test, i.e. rats swimming endurance test. significant increase in relative heart weight and glycogen content in myocardium and liver was also observed in ashwagandha treated group. ashwagandha treatment increased the duration of contractility in functional test ... | 2000 | 10720789 |
| withania somnifera root extract in the regulation of lead-induced oxidative damage in male mouse. | the importance of withania somnifera root extract in the regulation of lead toxicity with special reference to lipid peroxidative process has been investigated in liver and kidney tissues. while lead treatment (0.5 mg kg(-1)body wt. day(-1)for 20 days) enhanced hepatic and renal lipid peroxidation (lpo), administration of plant extract in the doses of 0.7 g kg(-1)and 1.4 g kg(-1)body wt. day(-1)along with equivalent doses of lead acetate for 20 days significantly decreased lpo and increased the ... | 2000 | 10816336 |
| the effect of extracts of cynomorium coccineum and withania somnifera on gonadotrophins and ovarian follicles of immature wistar rats. | the effects of water extracts of cynomorium coccineum and withania somnifera on ovarian follicular development and serum levels of fsh and lh were studied in immature 17-day-old and 25-day-old-wistar rats. water extracts of the plants were given to the animals per os in a dose of 47 mg/100 g body weight for 6 days. serum levels of fsh and lh were measured by elisa. folliculogenesis was studied with a light microscope. in 25-day-old rats, extracts of both plants elicited significant changes in go ... | 2000 | 10861976 |
| dendrite extension by methanol extract of ashwagandha (roots of withania somnifera) in sk-n-sh cells. | extension of dendrites and axons in neurons may compensate for and repair damaged neuronal circuits in the dementia brain. our aim in the present study was to explore drugs activating neurite outgrowth and regenerating the neuronal network. we found that the methanol extract of ashwagandha (roots of withania somnifera; 5 microg/ml) significantly increased the percentage of cells with neurites in human neuroblastoma sk-n-sh cells. the effect of the extract was dose- and time-dependent mrna levels ... | 2000 | 10884056 |
| review on some plants of indian traditional medicine with antioxidant activity. | a lot of medicinal plants, traditionally used for thousands of years, are present in a group of herbal preparations of the indian traditional health care system (ayurveda) named rasayana proposed for their interesting antioxidant activities. among the medicinal plants used in ayurvedic rasayana for their therapeutic action, some of these have been throughly investigated. in the present paper seven plants (emblica officinalis l., curcuma longa l., mangifera indica l., momordica charantia l., sant ... | 2000 | 10904144 |
| immunomodulatory activity of withania somnifera. | administration of an extract from the powdered root of the plant withania somnifera was found to stimulate immunological activity in babl/c mice. treatment with five doses of withania root extract (20 mg/dose/animal; i.p.) was found to enhance the total wbc count (17125 cells/mm(3)) on 10th day. bone marrow cellularity (27x10(6) cells/femur) as well as alpha-esterase positive cell number (1800/4000 cells) also increased significantly (p<0.001) after the administration of withania extract. treatm ... | 2000 | 10904163 |
| association of l-dopa with recovery following ayurveda medication in parkinson's disease. | ayurveda, the indian system of traditional medicine, uses a concoction of several spices, herbs and minerals for the treatment of diseases. in a clinical prospective study we have evaluated the efficacy of ayurveda treatment (a concoction in cow's milk of powdered mucuna pruriens and hyoscyamus reticulatus seeds and withania somnifera and sida cordifolia roots) in 18 clinically diagnosed (with a mean hoen and yahr value of 2.22) parkinsonian patients. as per ayurveda principles, 13 patients unde ... | 2000 | 10930594 |
| effect of withania somnifera glycowithanolides on iron-induced hepatotoxicity in rats. | glycowithanolides, consisting of equimolar concentrations of sitoindosides vii-x and withaferin a, isolated from the roots of withania somnifera dunal, have been reported to have an antioxidant effect in the rat brain frontal cortex and striatum. in the present study, the effect of 10 days of oral administration of these active principles, in graded doses (10, 20 and 50 mg/kg), was noted on iron overload (feso(4), 30 mg/kg, i.p.) induced hepatotoxicity in rats. apart from hepatic lipid peroxidat ... | 2000 | 11054855 |
| hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (withania somnifera, dunal) root. | hypoglycemic, diuretic and hypocholesterolemic effects of roots of w. somnifera (ashvagandha) were assessed on human subjects. six mild niddm subjects and six mild hypercholesterolemic subjects were treated with the powder of roots of w. somnifera for 30 days. suitable parameters were studied in the blood and urine samples of the subjects along with dietary pattern before and at the end of treatment period. decrease in blood glucose was comparable to that of an oral hypoglycemic drug. significan ... | 2000 | 11116534 |
| antistressor effect of withania somnifera. | withania somnifera is an indian medicinal plant used widely in the treatment of many clinical conditions in india. its antistressor properties have been investigated in this study using adult wistar strain albino rats and cold water swimming stress test. the results indicate that the drug treated animals show better stress tolerance. | 1999 | 10075127 |
| adaptogenic properties of six rasayana herbs used in ayurvedic medicine. | plants from all over the world such as eleutherococcus senticosus, panax ginseng, raponticum carthamoides, rhodiola rosea, withania somnifera and ocimum sanctum have been extensively evaluated for their adaptogenic potential. however, none of them has been successfully introduced as an adaptogen in the clinic. this paper discusses some of the problems in evaluation of adaptogens which have precluded their inclusion as clinically useful drugs. we further discuss our results with six rasayana plan ... | 1999 | 10404532 |
| studies on immunomodulatory activity of withania somnifera (ashwagandha) extracts in experimental immune inflammation. | the immunomodulatory activities of an indian ayurvedic medicinal preparation, i.e. extracts from ashwagandha, withania somnifera (l.) dunal (solanaceae), namely wst and ws2, were studied in mice for immune inflammation: active paw anaphylaxis and delayed type hypersensitivity (dth). immunomodulatory effect was assessed in if ige-mediated anaphylaxis as reduction of ovalbumin-induced paw edema, in animals treated with ws2 at doses of 150 and 300 mg/kg, and the results were compared with the stand ... | 1999 | 10616957 |
| withania somnifera and bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice. | the effects of daily administration of withania somnifera root extract (1.4 g/kg body wt.) and bauhinia purpurea bark extract (2.5 mg/kg body wt.) for 20 days on thyroid function in female mice were investigated. while serum triiodothyronine (t3) and thyroxine (t4) concentrations were increased significantly by bauhinia, withania could enhance only serum t4 concentration. both the plant extracts showed an increase in hepatic glucose-6-phosphatase (g-6-pase) activity and antiperoxidative effects ... | 1999 | 10619390 |
| subacute toxicity study of the combination of ginseng (panax ginseng) and ashwagandha (withania somnifera) in rats: a safety assessment. | ginseng (panax ginseng) and ashwagandha (withania somnifera) are widely used as geriatric tonics. both individually have not shown any toxicity on long term administration. study was planned to assess the safety of the combination by doing subacute toxicity study in rats with 90 days oral administration using three doses. food consumption, body weight, haematological, biochemical and histopathological parameters were studied. there was significant increase in body weight, food consumption and li ... | 1998 | 10225062 |
| therapeutic efficacy of ashwagandha against experimental aspergillosis in mice. | therapeutic efficacy of an indian ayurvedic medicinal preparation, ashwagandha [withania somnifera l. dunal (solanceae; root)] was evaluated against experimental aspergillosis in balb/c mice. ashwagandha given orally once daily for 7 consecutive days in a dose of 100 mg/kg after intravenous infection of aspergillus fumigatus prolonged the survival period of infected mice. this protective activity was probably related to the observed increases in phagocytosis and intracellular killing of peritone ... | 1998 | 9543708 |
| effect of ashwagandha on lipid peroxidation in stress-induced animals. | the aqueous suspension of root extract of an indian drug ashwagandha (withania somnifera l. (solanaceae)) was evaluated for its effect on lipid peroxidation (lpo) in stress-induced animals. elevation of lpo was observed in rabbits and mice after intravenous administration of 0.2 microg/kg of lipopolysaccharide (lps: from klebsiella pneumoniae) and 100 microg/kg of peptidoglycan (pgn: from staphylococcus aureus), respectively. the peak was reached immediately after pgn and 2-6 h after lps adminis ... | 1998 | 9582008 |
| systemic administration of defined extracts from withania somnifera (indian ginseng) and shilajit differentially affects cholinergic but not glutamatergic and gabaergic markers in rat brain. | although some promising results have been achieved by acetylcholinesterase inhibitors, an effective therapeutic intervention in alzheimer's disease still remains an important goal. sitoindosides vii-x, and withaferin-a, isolated from aqueous methanol extract from the roots of cultivated varieties of withania somnifera (known as indian ginseng), as well as shilajit, a pale-brown to blackish brown exudation from steep rocks of the himalaya mountain, are used in indian medicine to attenuate cerebra ... | 1997 | 9017665 |
| modification of bone marrow radiosensensitivity by medicinal plant extracts. | withaferin a (wa), a steroidal lactone, and plumbagin (pl), a naphthoquinone, from the roots of withania somnifera and plumbago rosea, respectively, have been shown to possess growth inhibitory and radiosensitizing effects on experimental mouse tumours. an aqueous extract of the leaves of ocimum sanctum (oe) was found to protect mice against radiation lethality. therefore, the radiomodifying effects of the above plant products on the bone marrow of the adult swiss mouse was studied. single doses ... | 1997 | 9227253 |
| effect of some indian herbs on macrophage functions in ochratoxin a treated mice. | the effect of indian herbs namely, asparagus racemosus, tinospora cordifolia, withania somnifera and picrorhiza kurrooa on the functions of macrophages obtained from mice treated with the carcinogen ochratoxin a (ota) was investigated. the chemotactic activity of murine macrophages was significantly decreased by 17 weeks of treatment with ota compared with controls. production of interleukin-1 (il-1) and tumor necrosis factor (tnf) was also markedly reduced. treatment with asparagus racemosus, t ... | 1997 | 9324000 |
| antioxidant activity of glycowithanolides from withania somnifera. | antioxidant activity of active principles of withania somnifera, consisting of equimolar concentrations of sitoindosides vii-x and withaferin a, was investigated for their effects on rat brain frontal cortical and striatal concentrations of superoxide dismutase (sod), catalase (cat) and glutathione peroxidase (gpx). results were compared with effects induced by deprenyl, an agent with well documented antioxidant activity. active glycowithanolides of w. somnifera (wsg) (10 and 20 mg/kg, i.p.), ad ... | 1997 | 9332168 |
| effect of trasina, an ayurvedic herbal formulation, on pancreatic islet superoxide dismutase activity in hyperglycaemic rats. | diabetes mellitus was induced in male cf strain rats by streptozotocin (stz) and hyperglycaemia and superoxide dismutase (sod) activity of pancreatic islet cells was assessed on days 7, 14, 21 and 28. stz induced significant hyperglycaemia and a concomitant decrease in islet cell sod activity. transina (tr), an ayurvedic herbal formulation comprising of withania somnifera, tinospora cordifolia, eclipta alba, ocimum sanctum, picrorrhiza kurroa and shilajit, had little per se effect on blood sugar ... | 1997 | 9332177 |
| antitumor and radiosensitizing effects of withaferin a on mouse ehrlich ascites carcinoma in vivo. | the antitumor and radiosensitizing effects of withaferin a (wa), a steroidal lactone from withania somnifera, was studied on ehrlich ascites carcinoma in vivo. the acute ld50(14) for wa in swiss mice was approximately 80 mg/kg. twenty-four hours after i.p. inoculation of 10(6) tumor cells, wa was injected i.p. at different dose fractions (5 or 7.5 mg/kg x 8, 10 mg/kg x 5, 20 or 30 mg/kg x 2) with or without abdominal gamma irradiation (rt, 75. gy) after the first drug dose. increase in life span ... | 1996 | 8619948 |
| studies on the immunomodulatory effects of ashwagandha. | the immunomodulatory activity of an indian ayurvedic medicinal preparation, ashwagandna (withania somnifera (l. dunal)) was studied in mice with myelosuppression induced by one or more of the following three compounds: cyclophosphamide, azathioprin, or prednisolone. the assessment of immunomodulatory activity was carried out by hematological and serological tests. a significant modulation of immune reactivity was observed in all the three animal models used. ashwagandha prevented myelosuppressio ... | 1996 | 8866726 |
| withanolide composition and in vitro culture of italian withania somnifera. | from italian plants of withania somnifera six withanolides were isolated, whose structures allowed us to assign the italian race of w. somnifera to the israel chemotype iii. in vitro cultures of italian w. somnifera under different conditions were obtained, as well as infection by agrobacterium rhizogenes. hplc analysis of in vitro derived tissues showed low contents of withanolides. | 1996 | 17252448 |
| withanolide production by root cultures of withania somnifera transformed with agrobacterium rhizogenes. | transformed root cultures of withania somnifera dunal (solanaceae) were obtained by infecting shoots cultured in vitro with agrobacterium rhizogenes lba 9402. they grew axenically in the absence of exogenous plant growth regulators in murashige and skoog's medium containing 3% (w/v) sucrose. the root cultures synthesized several withanolides of which withanolide d was isolated and identified. transformed root (clone hr (1)) showed a growth index of 20.07 and a withanolide d yield of 0.30 mg g(-1 ... | 1996 | 17252504 |
| withania somnifera dunal (ashwagandha): potential plant source of a promising drug for cancer chemotherapy and radiosensitization. | study of antitumor and radiosensitizing properties of w. somnifera (ashwagandha), a well known medicinal plant, have yielded encouraging results. the alcoholic extract of the dried roots of the plant as well as the active component withaferin a isolated from the extract showed significant antitumor and radiosensitizing effects in experimental tumors in vivo, without any noticeable systemic toxicity. withaferin a gave a sensitizer enhancement ratio of 1.5 for in vitro cell killing of v79 chinese ... | 1996 | 9055640 |
| in vivo growth inhibitory and radiosensitizing effects of withaferin a on mouse ehrlich ascites carcinoma. | adult swiss albino mice were inoculated intraperitoneally (i.p.) with 10 (6) ehrlich ascites carcinoma cells. twenty-four hours later they were given an i.p. injection of 10-60 mg/kg of withaferin a (wa), isolated from the roots of withania somnifera. the tumor growth and tumor free animal survival were studied for up to 120 days. in another experiment 30 mg/kg wa was injected i.p. to mice at 1, 3 or 5 days after tumor cell injection with or without acute abdominal exposure to 7.5 gy gamma radia ... | 1995 | 7656229 |
| antitumor and radiosensitizing effects of withania somnifera (ashwagandha) on a transplantable mouse tumor, sarcoma-180. | antitumor and radiosensitizing effects of alcoholic root extract of w. somnifera and their modification by heat were studied in vivo on sarcoma-180 grown on the dorsum of adult balb/c mouse. ashwagandha (at) was injected (ip) at a dose of 500 mg/kg body wt for 10 consecutive days into mouse bearing tumor of 50 +/- 5 mm3, with or without a local treatment of 10 gy gamma radiation (rt) or hyperthermia at 43 degrees c for 30 min (ht) or both on 5th day of at. the response was assessed on the basis ... | 1993 | 8225418 |
| anti-granuloma activity of iraqi withania somnifera. | the granuloma-tissue formation inhibiting activity of various fractions of an extract of the aerial parts of withania somnifera were established using subcutaneous cotton-pellet implantation in rats. antiinflammatory activity was retained in the methanolic fractions of the plant extract and was comparable to that of a 5 mg/kg dose of hydrocortisone sodium succinate. activity was attributed to the high content of biologically active steroids in the plant, of which withaferin a is known to be a ma ... | 1992 | 1434685 |
| in vivo growth inhibitory effect of withania somnifera (ashwagandha) on a transplantable mouse tumor, sarcoma 180. | withania somnifera is a medicinal plant used in the treatment of a variety of ailments in the ayurvedic system. alcoholic extract of the root of the plant was injected(ip) at daily doses of 200 to 1000 mg/kg body wt for 15 days starting from 24 hr after intradermal inoculation of 5 x 10(5) cells of s-180 in balb/c mice. solid tumor growth was monitored for 100 days. doses of 400 mg/kg and above produced complete regression of tumor after an initial growth, the percentage of complete response (cr ... | 1992 | 1512021 |
| treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. | the clinical efficacy of a herbomineral formulation containing roots of withania somnifera, the stem of boswellia serrata, rhizomes of curcuma longa and a zinc complex (articulin-f), was evaluated in a randomized, double-blind, placebo controlled, cross-over study in patients with osteoarthritis. after a one-month single blind run-in period, 42 patients with osteoarthritis were randomly allocated to receive either a drug treatment or a matching placebo for a period of three months. after a 15-da ... | 1991 | 1943180 |
| new bioactive compounds of plant origin. | crude extracts of withania somnifera (ws) and polygonum equisetiforme (pe) as well as the pure compounds isolated therefrom were screened for antibacterial and antifungal activity against 20 bacterial and 17 fungal cultures. the crude extract of pe and ws inhibited the growth of t. mentagrophyte, m. canis and a. boydii at an mic of 450-500 microg/ml whereas the pure compounds inhibited the growth at mic of 300-350 micro/ml. species of corynebacterium, bacillus, streptococcus and staphylococcus w ... | 1991 | 16414690 |
| contributions to the pharmacodynamic study of roots of withania somnifera dun species of pakistani origin. note iii: testing of analgesic activity of dichlormethanic and methanolic extract from withania somnifera roots. | 1990 | 2131560 | |
| anti-inflammatory activity of some iraqi plants using intact rats. | five plants (myrtus communis, apium graveolens, matricaria chamomilla, withania somnifera and achillea santolina) grown in iraq were assessed for their anti-inflammatory activity on intact rats by measuring the suppression of carrageenan-induced paw edema produced by 1/10 of the intraperitoneal ld50 doses for the respective 80% ethanol extracts. acetylsalicylic acid was used as the standard drug. results showed that the plants possessed varying degrees of anti-inflammatory activity and were clas ... | 1989 | 2601356 |
| withania somnifera, a plant with a great therapeutical future. | withania somnifera dun is a plant which drew the interest of many researchers in several countries, either for its active principles or for the extremely important pharmacodynamic or pharmacotherapeutic properties it has and first of all for the content in withanolides, substances with a sterol structure. | 1989 | 2814052 |
| long term effect of herbal drug withania somnifera on adjuvant induced arthritis in rats. | 1988 | 3248848 | |
| effect of withania somnifera on glycosaminoglycan synthesis in carrageenin-induced air pouch granuloma. | the effect of w. somnifera on glycosaminoglycan synthesis in the granulation tissue of carrageenin-induced air pouch granuloma was studied. w. somnifera was shown to exert significant inhibitory effect on incorporation of 35s into the granulation tissue. the uncoupling effect on oxidative phosphorylation (adp/o ratio reduction) was also observed in the mitochondria of granulation tissue. further, mg2+ dependent atpase activity was found to be influenced by w. somnifera. w. somnifera also reduced ... | 1987 | 2963652 |
| pharmacological studies on leaves of withania somnifera. | 1986 | 3703993 | |
| studies of medicinal plants of sri lanka. part 14: toxicity of some traditional medicinal herbs. | seventy five medicinal plants of the traditional ayurvedic pharmacopoeia of sri lanka have been screened chemically for alkaloids and pyrrolizidine alkaloids. of these, crotolaria juncea l. was found to contain pyrrolizidine alkaloids with biological effects consistent with pyrrolizidine alkaloid toxicity. feeding trials in rats with three plants lacking pyrrolizidine alkaloids, namely aegle marmelos (l.) corr., hemidesmus indicus (l.) ait. f. and terminalia chebula retz. produced hepatic lesion ... | 1985 | 4058035 |
| in vitro absorption of [14c]leucine during inflammation and the effect of antiinflammatory drugs in the jejunum of rats. | 1. inflammation was induced in the hindlegs of rats by formalin injection and the in vitro absorption of [14c]leucine was studied. 2. treatment of rats with formalin caused a reduction in the in vitro absorption of leucine from the mucosa of jejunum. 3. oral administration of oxyphenbutazone or a herbal anti-inflammatory drug (withania somnifera) prior to formalin injection resulted in no alteration in the jejunal absorption of [14c]leucine. | 1983 | 6860324 |
| influence of extra-intestinal inflammation on the in vitro absorption of 14c-glucose and the effects of anti-inflammatory drugs in the jejunum of rats. | inflammation was induced in the hind legs of rats by formalin injection and the in vitro jejunal absorption of 14c-glucose was studied. treatment of rats with formalin caused a reduction in the in vitro absorption of glucose from the jejunum. oral administration of oxyphenbutazone or a herbal anti-inflammatory drug (withania somnifera) prior to formalin injection, resulted in no alteration in the jejunal absorption of glucose. | 1983 | 6872332 |
| treatment of tropical eosinophilia with an ayurvedic compound - a clinical trial. | the effect of an ayurvedic preparation consisting of swasakutara, curcuma longa (haridra) and withania somnifera (asvagandha) is accessed in 12 patients of tropical eosinphilia. the modern control drug hetrazan is used in another batch of 11 patients for comparison. the ayurvedic compound causes complete relief of most of the clinical signs and symptoms associated with the disease and reduces e.s.r. significantly. however the drug has no effect on the level of circulating eosinophils. | 1983 | 22556981 |
| current status of plant products reported to inhibit sperm. | this report reviews research on plant-derived agents that prevent sperm production if taken orally by the male or that incapacitate or kill sperm on contact if used vaginally by the female. it would be of great value to develop fertility inhibitors that are totally selective for reproductive systems and enzymes, and there is a possibility that a plant-derived drug may have this effect. plants that have been studied for their fertility inhibiting effects in the male include: aristolochia indica l ... | 1982 | 12179631 |
| variations in the antitumour constituents of withania somnifera dunal. | 1974 | 4416850 | |
| [morphology and anatomy of indian roots of withania somnifera (author's transl)]. | 1974 | 4427962 |