Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| absence of seizure activity following focal cerebral injection of enkephalins in a primate. | baboons (papio papio) with photosensitive have been chronically prepared with guide cannulae and deep electrodes to study the effects of focal injections of opioids. in the hippocampus, amygdala and thalamus (centre median) 50--100 micrograms morphine, 20--100 micrograms met-enkephalin or 2--10 micrograms fk 33,824 do not induce local or general electrographic or motor signs of epilepsy. the acute epileptogenic effect of morphine and enkephalins observed in rats is not a general phenomenon where ... | 1981 | 7302294 |
| [the problem of the use of mercurials cosmetics in senegal (author's transl)]. | the use of skin-lightening preparations appears to be a problem for the coloured women in africa as well as for the black people in general. the mercurial creams occupy a place of choice into the most useful products for the skin depigmentation. an epidemiological study from twenty senegalese women using mercurials cosmetics has permitted to determine a mean value of 155,75 +/- 75,38 ppm hg in scalp hair while the normal level is less than 10 ppm. an experimental study was realised with monkeys ... | 1981 | 7302943 |
| [new data from a comparative study of cerebral blood volume and eeg during epileptic seizures in papio papio (author's transl)]. | a new approach to the cerebral and extracerebral circulation phenomenon, during generalized seizure discharges (gsd) in the baboon is described. it is based upon the measurement of comparative variations of the regional blood volume (rbv) a new technique. first results demonstrate the existence of an extracerebral vascular structure of the face which is quite sensitive to the ictal phenomenon and which we have named the 'nasal region'. on the whole, when bursts of spike/waves occur the mean arte ... | 1981 | 7345492 |
| [modification of frontal and occipital cortical excitability provoked by trains of flashes in papio papio (author's transl)]. | the experimental conditions necessary for obtaining an evoked paroxysmal response from the frontal cortex were studied in the baboon papio papio. the trigger stimulus was comprised of an isolated flash preceded by a train of intermittent light stimulation (sli). two conditions were necessary for the appearance of paroxysmal responses: a subconvulsant dose of dl-allylglycine had to be injected at least 3 h previous to recording, and a sufficient number of sli trains had to be presented to the ani ... | 1981 | 7345487 |
| opposite effects of lorazepam on two kinds of myoclonus in the photosensitive papio papio. | the action of lorazepam was studied in photosensitive baboons. animals were either naturally very photosensitive or rendered photosensitive by a previous injection of allylglycine. intravenous administration of varying doses, from 0.05 to 0.5 mg/kg, of lorazepam blocked the myoclonus induced by intermittent light stimulation in all the animals. however, in the naturally photosensitive baboon the injection of lorazepam favoured the appearance of spontaneous myoclonus with no important eeg modific ... | 1981 | 6172264 |
| cortical unit activity during intermittent photic stimulation in papio papio. relationship with paroxysmal fronto-rolandic activity. | extracellular records have been made in the fronto-rolandic (fr), parietal and occipital cortical areas in papio papio injected with allylglycine and paralysed with a synthetic curarizing agent. the organization of the unit discharges in the absence of intermittent light stimulation (ils) is normal. during ils, unit discharges in the fr cortex are organized in bursts of high frequency that are synchronous with the spikes of the eeg paroxysmal discharges (pd) in the same territory; this burst-org ... | 1981 | 6166452 |
| [impairments in initiation and execution of a visually-guided movement in baboon during cooling or after lesion of the internal pallidal segment (author's transl)]. | in the present experiment, the participation of the internal part of the globus pallidus (gp) in the initiation and the execution of a pointing movement was investigated in four baboons (papio papio). the effects of gp exclusion on the response latency, the movement execution time and the pointing accuracy were analyzed. two different methods were used to exclude the gp. in two cases, cryogenic blockade was induced using a chronic cryoprobe, implanted contralaterally to the operant hand. two oth ... | 1981 | 7230049 |
| characterization of a proteoglycan of high electrophoretic mobility. | proteoglycans from articular cartilage of young baboons (papio papio) were fractionated on an associative density gradient. material from the top of the gradient was shown to contain a proteoglycan of high electrophoretic mobility on large porosity gels. associated and/or contaminating proteins were removed by ion-exchange chromatography on deae-cellulose and subsequent gel filtration on sepharose 4b in the presence of 0.1% sds. the electrophoretically homogeneous proteoglycan (kd 0.43 on sephar ... | 1981 | 7470505 |
| cerebral and extracerebral blood volume in generalized seizures in the baboon papio papio. | relative variations of the cerebral and extracerebral blood volume (cbv) were measured continuously by a novel atraumatic method in baboons to explore the relationship between changes in the systemic circulation and in the cerebral (and extracerebral) vascular responses, before, during and after generalized seizures induced by photic stimulation. major bursts of generalized spikes and waves are accompanied by an increase of the mean arterial pressure and of the cerebral blood volume and a decrea ... | 1981 | 6161785 |
| [observation of a photosensitive syndrome in macaca nemestrina (author's transl)]. | out of a group of 12 m. nemestrina (originating from malaysia), 9 adults had shown clinical signs induced by ils at 25 c/sec. six of them (3 males, 3 females) were very photosensitive; however, only 2 presented eyelid and/or head jerks after the end of ils (level 4), but never a generalized seizure. tactile periorbital stimuli favoured myoclonus. in all but the two of level 4, the intensity of clinical signs varied from one day to the next. in all implanted adult macaques, spontaneous paroxysmal ... | 1981 | 7323374 |
| calcification of thymic hassal's corpuscles in prenatal and postnatal nonhuman primates. | calcification of thymic hassal's corpuscles was found in three prematurely delivered fetuses, one each of the species papio papio, macaca mulatta, and saimiri sciureus. the cause of these lesions was not determined. | 1980 | 7464030 |
| paroxysmal visual evoked potentials (pveps) in papio papio. ii. evidence for a facilitatory effect of intermittent photic stimulation. | 1980 | 6160980 | |
| paroxysmal visual evoked potentials (pveps) in papio papio. i. morphological and topographical characteristics. comparison with paroxysmal discharges. | 1980 | 6160979 | |
| sustained limbic seizures induced by intraamygdaloid kainic acid in the baboon: symptomatology and neuropathological consequences. | in papio papio baboons chronically prepared for cortical and deep electroencephalographic recording, injection of kainic acid into the amygdala (7 animals) or temporal pole (2 animals) gave rise to focal epileptic discharges lasting 15 to 150 hours. electrographically, the seizure activity spread ipsilaterally and contralaterally within the limbic system but did not become generalized. the principal associated motor signs were arrest of movement and oral automatisms. histological examination aft ... | 1980 | 6254439 |
| a medulloblastoma in a baboon (papio papio). | a transitional medulloblastoma was found in the cerebellum of a young female baboon. the primary lesion that permitted its discovery was papillary and retinal edema in the peripapillary zone. | 1980 | 7421118 |
| eeg and anticonvulsant effects of dipropylacetic acid and dipropylacetamide in the baboon papio papio. | the ability of dipropylacetic acid (dpa) and dipropylacetamide (dpm) to modify eeg and seizure activity was assessed in 4 female and 3 male papio papio. doses of 30-60 mg/kg of dpa given at intervals over an 8 h period produced blood levels of 19-44 micrograms/ml which were not protective against intermittent light stimulation (ils). administration of 150-200 mg/kg doses at intervals over a 36 h period produced blood levels greater than 150 micrograms/ml and were highly protective against ils. s ... | 1980 | 6158417 |
| circadian periodicity of brain activity and urinary excretion in the epileptic baboon. | a 24-h rhythm in the proclivity of the baboon papio papio to exhibit a seizure response to intermittent light stimulation (ils) has been uncovered. seizure response to ils was found to be greatest in the morning at about 0900 h, 2 h after lights on, and least severe in the evening at about 2000 h 1 h after lights off. urine cortisol and potassium excretion rhythms followed the same pattern as seizure susceptibility and sodium rhythms were 3 or 4 delayed. mean values for urine cortisol per 4 h ra ... | 1980 | 6772040 |
| proteoglycan populations of baboon (papio papio) cartilages from different anatomical sites: gel electrophoretic analysis of dissociated proteoglycans and of fractions obtained by density gradient centrifugation. | proteoglycans extracted by 4 m guanidinium chloride from different cartilages and vertebral discs of young baboons (papio papio) were purified by ion-exchange chromatography and assessed by gel electrophoresis. proteoglycans fractionated by equilibrium density gradient centrifugation under 'dissociative' conditions were similarly purified and assessed. (1) non-fractionated proteoglycans from articular, nasal, laryngeal, tracheal, costal, vertebral plate and ear cartilage and from anulus fibrosus ... | 1980 | 6770906 |
| effects of the bicyclic gaba agonist, thip, on myoclonic and seizure responses in mice and baboons with reflex epilepsy. | thip, 4,5,6,7-tetra hydroisoxazolo[5,4-c]pyridine-3-ol, has been evaluated as an anticonvulsant in dba/2 mice showing audiogenic seizures, and in baboons, papio papio, with photosensitive epilepsy. no protection against seizures was seen after thip, 1-4 mg/kg, intraperitoneally in mice. thip, 8 mg/kg, reduced clonic and subsequent seizure responses at 1 h. it also reduced rectal temperature and impaired posture and spontaneous activity. in baboons thip, 0.25-8 mg/kg, iv, failed to protect agains ... | 1980 | 6767614 |
| experimental study on epileptogenic transference phenomena in kindled senegales baboons, papio papio. | 1980 | 7216051 | |
| initiation of a goal-directed movement in the monkey. role of the cerebellar dentate nucleus. | the participation of the dentate nucleus (dn) in the initiation of a voluntary movement was investigated in five baboons (papio papio). in these experiments, we have analyzed the effects of excluding the dn on the latency (reaction time, rt) of a learned goal-directed movement. two techniques were for excluding the dn. in three animals, the structure was cooled with a probe, stereotaxically implanted on the side ipsilateral to the active hand. in two others, a partial electrolytic destruction of ... | 1980 | 7428885 |
| [stereological analysis of normal papio papio liver parenchymal cells (author's transl)]. | stereological analysis of normal papio papio liver parenchymal cells has been performed according to the method of weibel (1969). the study was carried out on liver samples collected from 3 males and 3 females. sampling was done at three levels of magnification (x 250, x 5 000, x 15 000) without taking into consideration the lobular variations. the lobular stereological model included the hepatocyte, all the cellular organelles and the extra-hepatocytic space compartment. surface and volume dens ... | 1980 | 7212697 |
| gamma-glutamyl transferase distribution in the organs of papio papio and macaca fascicularis. | tissue distribution of non solubilized gamma-glutamyl transferase (ggt) was studied in eight baboons and ten macaques. in both, ggt is mainly in kidney, pancreas and liver. this tissue distribution of ggt is roughly similar to that observed in man. | 1980 | 6107384 |
| dna sequence of baboon highly repeated dna: evidence for evolution by nonrandom unequal crossovers. | a highly repeated dna was isolated from the west african baboon (papio papio) as a 343-base-pair fragment after digestion of total baboon dna with the restriction endonuclease bamhi. the dna sequence of this fragment was obtained by chemical cleavage methods and is compared with the dna sequence of related highly repeated primate dnas from african green monkey (cercopithecus aethiops) and man. the 343-base-pair baboon repeat consists of two related but nonidentical wings of 172 and 171 base pair ... | 1980 | 6246524 |
| silent delta-globin gene in old world monkeys. | the delta polypeptide chain is present in the adult hemoglobin of all higher primates except old world monkeys. because old world monkeys have evolved from higher primate ancestors, it can be concluded that the ability to synthesize this polypeptide has been lost relatively recently. it is shown here that the gene for delta globin exists in two of these species, the rhesus monkey (macaca mulatta) and the baboon (papio papio). restriction endonuclease fragments of monkey genomic dna bearing the d ... | 1980 | 6251467 |
| transient abolition of generalized photosensitive epileptic discharge in humans by apomorphine, a dopamine-receptor agonist. | apomorphine, an agonist of dopamine receptors, blocks or significantly reduces photically induced seizures in the baboon (papio papio). we therefore studied the effect of subcutaneously administered apomorphine in 11 patients with generalized photosensitive epilepsy. visual evoked potentials were not altered by apomorphine, but in nine patients apomorphine transiently blocked the epileptic photosensitivity for an average of 45 minutes. therefore, dopaminergic mechanisms play a role in the pathop ... | 1980 | 7191513 |
| rapid evolution of animal mitochondrial dna. | mitochondrial dna was purified from four species of higher primates (guinea baboon, rhesus macaque, guenon, and human) and digested with 11 restriction endonucleases. a cleavage map was constructed for the mitochondrial dna of each species. comparison of the maps, aligned with respect to the origin and direction of dna replication, revealed that the species differ from one another at most of the cleavage sites. the degree of divergence in nucleotide sequence at these sites was calculated from th ... | 1979 | 109836 |
| maternal-fetal transfer of melatonin in the non-human primate. | melatonin was detected in the circulation of the near-term rhesus monkey (macaca mulatta) and baboon (papio papio) fetus. we determined whether the source could be the mother by studying placental transfer of melatonin in the rhesus monkey. when [3h]melatonin was administered i.v. to the mother it promptly appeared in the fetal circulation; the rates of disappearance of [3h]melatonin in the maternal and fetal circulations were parallel. the rapid decrease in circulating [3h]melatonin was associa ... | 1979 | 113767 |
| contribution of vision to muscle responses in monkey during free-fall: visual stabilization decreases vestibular dependent responses. | in a previous study the muscle responses from the lower limbs were studied in the baboon (papio-papio) during sudden falls. on the other hand, recent findings concerning the role of vision in the control of posture during rapid perturbations in man have stimulated the present investigation. emg activities were recorded from the fully conscious animal using chronic electrodes implanted in various muscles (splenius, quadriceps femoris, soleus, and tibialis anterior). for testing, the monkey was se ... | 1979 | 115701 |
| photomyoclonic seizures in the baboon, papio papio. | the inborn seizure response of papio papio to intermittent light stimulation has been reviewed as a model of human epilepsy. the electrographic and clinical features have been described and useful methodology has been outlined. a diurnal cyclicity in seizure responsiveness has been described with greatest seizure severity at 8 am in parallel with a rise in urinary output of cortisol. hormonal influences on the seizure response have been described for ethinyl estradiol, thyroxin, and triiodothyro ... | 1979 | 39008 |
| comparison of the karyotypes of four cercopithecoidae: papio papio, p. anubis, macaca mulatta, and m. fascicularis. | the karyotypes of two species of baboons, papio papio and p. anubis, and of two species of macaca, m. mulatta and m. fascicularis, are compared after the use of numerous banding techniques. no difference was detected between the karyotype of the two papio species. however, a minor change in the t-staining of a short segment, probably heterochromatic, could be detected between the papio species and m. mulatta. a paracentric inversion exists between these three and m. fascicularis. these karyotype ... | 1979 | 83931 |
| liver microsomal oxidations in baboon (papio papio). | 1. the activity of baboon (papio papio) hepatic microsomes was evaluated using several model substrates. 2. as with other species studied in this laboratory, baboon microsomal enzyme activities were in the decreasing order: aldrin epoxidation greater than p-nitroanisole o-demethylation greater dihydroisodrin hydroxylation greater than benzo(a)pyrene oxidations. 3. substrate, time, protein and cofactor requirements were examined. 4. activities of stored frozen tissue and microsomal pellets remain ... | 1979 | 117644 |
| electroencephalographic and behavioral effects of a gaba agonist (muscimol) on photosensitive epilepsy in the baboon, papio papio. | muscimol, 0.25-1.0 mg/kg, i.v., was administered acutely to 4 adolescent baboons, papio papio, that show photically induced epilepsy. on the eeg, slowing of background rhythms was associated with the appearance of spikes, polyspikes, and recurring symmetrical spike-wave complexes. these changes were maximal 0.5-2 hr after muscimol injection. regular testing with intermittent light stimulation showed either no change from control responses or a more severe epileptiform eeg 0.1-3 hr after muscimol ... | 1979 | 113208 |
| effects of opiate-like peptides, morphine, and naloxone in the photosensitive baboon, papio papio. | the effects of intracerebroventricular (i.c.v.) or systemic injections of met- or leu-enkephalin, beta-endorphin, fk 33.824 (d-ala2, mephe4, met(o5)-ol-enkephalin) and of morphine and naloxone have been studied in baboons, papio papio, which spontaneously show photically induced epileptic responses. animals were chronically implanted with epidural or deep recording electrodes and a cannula in one lateral ventricle, and tested whilst seated in a primate chair. in some animals the natural syndrome ... | 1979 | 223724 |
| osteosarcoma of the mandible of a baboon (papio papio): morphological and virological (oncornavirus) studies, with a review of neoplasms previously described in baboons. | 1979 | 118988 | |
| anticonvulsant action of yg 19-256 in baboons with photosensitive epilepsy. | yg 19-256, 4-(1,3,4,9b-tetrahydro-5 methyl-2h-indeno[1,2-c]pyridine-2-yl)-2-butanone methane sulphonate, 1-3 mg/kg i.v., abolished or reduced photically-induced myoclonic responses for 1.5-6.5 h in baboons, papio papio, without producing signs of acute neurological toxicity. | 1979 | 111964 |
| anticonvulsant activity in photosensitive baboons, papio papio, of two new 1,5 benzodiazepines. | two new 1,5 benzodiazepines have been evaluated acutely as anticonvulsants in baboons, papio papio, with photosensitive epilepsy. bau 426 (8-chlor-6-[2-chlorphenyl]-4h-s-triazolo-[4,3-a] [1,5-benzodiazepin-5-[6-h]on) and bau 500 (analogue of bau 426 with [2-trifluor methylphenyl] substituted for [2-chlorphenyl]), 0.1--5.0 mg/kg, were administered i.v. to baboons with and without priming with d,l allylglycine. bau 426 or bau 500, 0.1--0.2 mg/kg, produced partial or transient protection against ph ... | 1979 | 108705 |
| [desmodonte renewal in baboons (papio papio)]. | turnover of desmodontal ligament is analysed in the baboon using labeling, biochemical and histological techniques. in baboons, as previously observed in rodents, turnover of proteins labelled by 3h glycine may be described by a single exponential after the ninth day, the half life of which is more than two weeks. biochemical data show that proteins renewed are mostly collagen. | 1979 | 109222 |
| contribution of dehydroepiandrosterone and its sulfate to estradiol in baboon pregnancy. | the metabolic clearance rates (mcr), conversion ratios (c), interconversion (rho), production rates (pr), secretion rates (sr), and relative contributions of maternal dehydroepiandrosterone (d) and d-sulfate (ds) to serum estradiol (e2) were determined in five pregnant baboons (papio papio; 154-167 days gestation, term = 184 days) by constant intravenous infusion of [3h]ds and [14c]d. mcr-d (mean +/- se) was greater (39.2 +/- 3.3 1/day.kg, p less than 0.001) than mcr-ds (3.1 +/- 0.3 1/day.kg). b ... | 1978 | 150235 |
| identification of 7xi-hydroxytetrahydrocortisol and 7xi-hydroxytetrahydrocortisone from urine of newborn baboons (papio papio). | two highly polar, unconjugated metabolltes of tetrahydrocortisol and tetrahydrocortisone, which had been shown previously to account for greater than 40% of [14c]cortisol (f) administered to baboon neonates, were isolated from urine of a term newborn animal. metabolites were extracted with ethyl acetate, purified by sequential paper chromatography and crystallization, and identified by chemical and biochemical procedures. both metabolites of f are 5beta-pregnanes with a hydroxyl of unknown orien ... | 1978 | 663983 |
| mechanisms involved in mandibular condylopathy secondary to intraarticular injections of glucocorticoids. | pharmacologic doses of triamcinolone hexacetonide were injected intramuscularly or intraarticularly in immature papio papio baboons. the mandibular condyle served as a model for histologic examinations concerning the effect of glucocorticoid hormone on cartilage and bone. biochemical examinations of blood and urine indicated the development of distinct hypophosphatemia, hypercalcemia followed by hyperphosphaturia, and hypocalciuria. serum alkaline phosphatase activity rose during the initial pha ... | 1978 | 413894 |
| negative effects of chronic hemicerebellectomy of epileptiform after-discharges elicited by focal cortical stimulation in baboons (papio papio). | the influence of chronic hemicerebellectomy on cortical epileptiform after-discharge (ad) induced by focal electrical stimulation was studied in the baboon. these preliminary results include 22 ads elicited from motor cortex and 22 ads elicited from premotor cortex before and after hemicerebellectomy. only full-developed, generalized seizures with postictal silence were considered. eeg morphology, average duration and average current threshold were compared for each set of ictal events. no signi ... | 1978 | 75096 |
| [buccal candidiasis and intestinal invagination in captive baboons, papio papio]. | 1978 | 715290 | |
| [pharmacologic approach to papio papio photosensitive epilepsy]. | 1978 | 98965 | |
| red cell and serum enzymes of guinea baboon (papio papio). | variants of some erythrocyte and serum enzymes have been studied among several blood samples of guinea baboon (papio papio). variation occurred in two red cell enzymes, g6pd and nadh diaphorase, and in serum esterase. all studied animals had a complete uniformity in other enzyme systems (acp, 6pgd, ca, ak, and cholinesterase at e1 locus). data obtained in the present work have been discussed and compared with those reported among other baboon species. | 1978 | 96267 |
| [identity of karyotypes of papio papio and macaca mulatta in r, g, c banding and ag-nor]. | 1978 | 115371 | |
| complete or almost complete analogy of chromosome banding between the baboon (papio papio) and man. | 1978 | 97206 | |
| blockade of epileptic responses in the photosensitive baboon, papio papio, by two irreversible inhibitors of gaba-transaminase, gamma-acetylenic gaba (4-amino-hex-5-ynoic acid) and gamma-vinyl gaba (4-amino-hex-5-enoic acid). | the anticonvulsant potency and neurological toxicity of two new catalytic inhibitors of gaba-transaminase have been assessed in acute experiments in baboons with a natural syndrome of photic epilepsy. gamma-acetylenic gaba, 160--200 mg/kg, or gamma-vinyl gaba, 450--950 mg/kg, intravenously, gave complete protection against generalised myoclonus or seizure responses induced by photic stimulation (in baboons without or with priming with subconvulsant doses of allylglycine). the protection became m ... | 1978 | 100812 |
| [candidiasis and obstructive intestinal tumor in a captive baboon 'papio papio' (desm.)]. | report of a case of candidiasis of the digestive tract associated to an obstructive epithelial tumor, with great invasive ability, in a captive baboon, papio papio (desm.). included is a discussion of the incidence of some intestinal disturbances involving candidiasis of subhuman primates. | 1978 | 104181 |
| secondarily generalized convulsive seizures induced by daily amygdaloid stimulation in rhesus monkeys. | amygdaloid kindling in rhesus monkeys resulted in development of secondarily generalized convulsive seizures in an average of 196 days. prior pharmacologic (bemegride) kindling accelerated this seizure development in one animal. none of the animals reached the stage 5 primary generalized seizure of baboons (papio papio), even after 400 daily amygdaloid stimulations. seizure stage instability, with frequent regression to an earlier stage, and the difficulty of establishing a generalized seizure t ... | 1978 | 106328 |
| myoclonus developing after vermisectomy in photosensitive papio papio. | two vermisectomized photosensitive baboons exhibited two different types of myoclonus, one induced by intermittent light stimulation (ils) and the other occuring "spontaneously". the characteristics of these two types of myoclonus are described from a clinical and from an ecog point of view. myoclonus induced by ils (ml) started at the eyelids and secondarily invaded the face and body; it was always preceded by frontorolandic spike-waves or polyspike-waves. the "spontaneous" myoclonus which foll ... | 1978 | 78825 |
| photosensitive epilepsy in papio papio as a model for drug studies. | photically-induced epilepsy in papio papio provides a convenient model for assessing the efficacy and the acute neurological toxicity of new anticonvulsant drugs prior to clinical trial. its drug sensitivity is broadly comparable to that of generalized seizures in man. it also shares some specific properties with syndromes of reflex epilepsy in man. | 1978 | 220003 |
| mycobacterium bovis infection in baboons (papio papio). | two tuberculin-positive baboons in a primate colony were found to have grossly visible tuberculous lesions in the liver, spleen, lung, and mediastinal lymph nodes on necropsy. results of histopathologic examination of the tissues showed granulomas with langhans giant cells. an acid-fast organism was isolated from tissues of each baboon; the isolates were identified as mycobacterium bovis by being negative for niacin production and nitrate reduction and by their susceptibility to thiophen-2-carb ... | 1977 | 324436 |
| [the sheath of scarpa ganglion cells in the baboon papio papio]. | the sheath of the bipolar perikarya of the vestibular ganglion (scarpa) in papio papio is made up of several schwann cells which concur to form loose myelin, and at most five layers of compact myelin. most of the schwann cytoplasmic layers stop at the emergence of both neurites, forming at the point an incomplete ranvier half-node. the constitution of the vestibular perikaryal sheath in papio is intermediate between those previously described in the rat and in the human. | 1977 | 404837 |
| human pb, human post-pb, and nonhuman primate pb proteins: immunological and biochemical relationships. | the isolation and characterization of a protein from human parotid saliva termed the "post-pb protein" is described. by several criteria, this protein is closely related to the human pb proteins. when reacted against antisera to human pb protein in double diffusion, the post-pb protein is found to be related to the pb proteins by lines of identity. however, when the partial n-terminal amino acid sequences of the post-pb protein and pb proteins are compare, the sequences are not identical. becaus ... | 1977 | 412494 |
| connections of latero-dorsal nucleus of the thalamus. ii. experimental study in papio papio. | modifications of the latero-dorsal (l.d.) nucleus of the thalamus have been observed earlier in man in relation to limbic lesion of various etiologies. our proposal was to determine the role of l.d. in memory disturbances. we attempted to study the connections of l.d. in papio papio baboon after surgical lesion using silver impregnations as well as traditional techniques. we found three afferent pathways: from the fornix, the posterior cingulate and the parietal cortex (area 7). the most importa ... | 1977 | 412567 |
| nonhuman primates: laboratory animals of choice for neurophysiologic studies of sleep. | a systematic study was made of several nonhuman primates to learn more about their relative usefulness for studies of sleep. species studied included the guinea baboon (papio papio), kenya or yellow baboon (p cynocephalus), olive baboon (p anubis), sacred baboon (p hamadryas), vervet monkey (cercopithecus aethiops), rhesus monkey (macaca mulatta), bonnet monkey (m radiata), crab-eating monkey (m fascicularis), patas monkey (erythrocebus patas), chimpanzee (pan troglodytes), mongoose lemur (lemur ... | 1977 | 201798 |
| increasing fetal adrenal formation of cortisol from pregnenolone during baboon (papio papio) gestation. | 1977 | 413590 | |
| proteoglycan populations of baboon (papio papio) articular cartilage. | 1. gel electrophoresis of proteoglycans extracted with use of 4 m-guanidinium chloride from baboon (papio papio) articular cartilage and purified on deae-cellulose in 8 m-urea yielded three bands on electrophoresis in polyacrylamide/agarose gels: two wide bands close together (i and ii) and a third, thinner and more rapidly moving band (iii). 2. gel electrophoresis of fractions from direct 'dissociative' gradients showed that these bands were partially separated (buoyant density of i greater tha ... | 1977 | 405971 |
| seizure activity in photosensitive baboons following antidepressant drugs and the role of serotoninergic mechanisms. | laboratroy and clinical evidence indicates that tricyclic antidepressants lower seizure threshold and in high doses may induce generalised seizures. in baboons with photosensitive epilepsy (papio papio) the effects of 2 tricyclic antidepressants (imipramine and chlorimipramine) and of maprotiline and nomi fensine have been studied (i.v. dose range 1-20 mg/kg. imipramine, chlorimipramine and maprotiline (10 mg/kg i.v.) lowered seizure threshold to a comparable extent, whereas nomifensine (10 mg/k ... | 1977 | 402667 |
| effect of nomifensine on brain amines and epilepsy in photosensitive baboons. | 1. the literature, both clinical and experimental, suggests that tricyclic antidepressants are potentially epileptogenic. using the experimental model of epilepsy provided by the photosensitive baboon, papio papio, the epileptic potential of four antidepressant drugs, two of which are tricyclic, has been assessed. the drugs used were imipramine 1, 10 and 20 mg/kg, chlorimipramine 1, 10 and 20 mg/kg, maprotiline 1 and 10 mg/kg and nomifensine 10 and 20 mg/kg. in a second series of experiments the ... | 1977 | 911646 |
| influence of cortisone on seizure activity in the papio papio model of epilepsy. | 1977 | 408824 | |
| a comparison of the effects of chronically administered diazepam and phenobarbital and learning in the papio papio model of epilepsy. | 1977 | 408818 | |
| [biological and biochemical characterization of a new isolate of baboon papio papio endogenous type c virus]. | a new strain of baboon papio papio endogeneous type c virus was isolated from the testis of an animal of this species. the strain was characterized biochemically and biologically. it presents a host-range different from that of the prototype strain of the same virus. | 1977 | 195750 |
| acute dystonia as an idiosyncratic response to neuroleptics in baboons. | among 25 baboons, papio papio, 2 consistently showed acute dystonic reactions, with mouthing, compulsive gnawing and limb and trunk dystonia, following the intravenous administration of neuroleptics and related drugs (haloperidol, 0-6-1-2 mg/kg; pimozide 0-5-2-5 mg/kg; chlorpromazine 5-25 mg/kg; metoclopramide 1-5-1-7 mg/kg; oxyperomide 0-25-1-0 mg/kg). the syndrome was not seen after thioridazine (3-7 mg/kg). the dystonic responses occurred within 1-2 h of drug injection and lasted for 2-24 h. ... | 1977 | 406964 |
| serum dehydroepiandrosterone and dehydroepiandrosterone sulphate in baboon (papio papio) pregnancy. | dehydroepiandrosterone (d) and dehydroepiandrosterone sulphate (ds) concentrations were determined by radioimmunoassay in peripheral sera of non-pregnant, pregnant (55 days to term) and newborn baboons and in umbilical sera of animals delivered by caesarean section close to term. d concentrations (mean +/- sd, microng/100 ml, n) in non-pregnany animals (1.61 +/- 1.32, 23) were not different (p greater than 0.05) from those during pregnancy (1.80 +/- 1.21, 101). ds concentrations, expressed as un ... | 1977 | 141185 |
| serum progesterone in the pregnant baboon (papio papio). | 1976 | 819050 | |
| [eeg effects of sodium nitroprusside and hemodynamic references]. | a study was performed on baboons (papio papio) of various hemodynamic and eeg effects of sodium nitroprussiate (snp), substance with powerful vasodilator action. three different procedures of drug injection were used: (1) in isolation, either in doses close to those used in clinical practice or in high doses; (2) after neuroleptanalgesia (nla); (3) after causing vasospasm. with isolated snp, effects on blood pressure were unstable; in certain cases hypotension could be maintained only with toxic ... | 1976 | 56263 |
| [toporaphy of chromosome banding in papio papio]. | results are given of a study of chromosome banding patterns of papio papio. the 22 chromosomes are described and illustrated and their measurements are given. | 1976 | 818939 |
| [experimental study of the cerebrovascular effects of sodium nitroprusside in the baboon papio papio. its action on the experimental vasospasm]. | sodium nitroprusside (snp) has been suggested as hypotensive agent in the surgery of cerebral aneurysms. as a preliminary step to neurosurgery, a study of its cerebro-vascular and eeg action had been carried out in 42 papio-papio baboons. on the unanaesthetized analgesic-free animal, doses below 20 mumg/kg/min. induce only a moderate decrease of mean arterial blood pressure (mabp), a slight rise of intracranial pressure (icp) and a neat fall of cerebro-vascular resistance (cvr) without eeg modif ... | 1976 | 822367 |
| biogenic amines and the photomyoclonic syndrome in the baboon, papio papio. | the role of biogenic amines in the proclivity of the baboon, papio papio, to exhibit an epileptoid response to flashing light was studied. intraventricular injections of epinephrine and norepinephrine reduced or blocked the photomyoclonic syndrome without modifying ongoing behavior. epinephrine was effective at doses of 100 mg and more, and norepinephrine was effective at doses of 250 mg and more. neither intraventricular injections of as much as 1.5 mg of dopamine and 1.0 mg of serotonin nor ch ... | 1976 | 812981 |
| the relationship between the anticonvulsant properties of sc-13504 and its plasma levels, measured by polarography, in baboons with photosensitive epilepsy. | sc-13504 was given intravenously to baboons with photosensitive epilepsy, papio papio, with and without prior administration of allylglycine. plasma levels of the drug were determined by differential pulse polarography and correlated with behavioural changes and the anticonvulsant action of the drug. protection against photically induced seizures or self-sustaining myoclonic responses was seen 30 to 120 min after sc-13504, 4-8 mg/kg (when plasma levels were 1 mug/ml or greater). eeg and neurolog ... | 1976 | 827776 |
| epilepsy and sleep organization in the baboon papio papio. | effects of different types of epileptic seizure on the sleep organization of baboon were studied through 12 h polygraphic recordings. photically induced myoclonic jerking did not modify sleep organization. photically induced genalized convulsions produced an increase of the waking stage (awa) and reduction of rem stage. pentetrazol-induced generalized convulsions not only increased awa and reduced rem, but also elicited various modifications of stages i, ii and iii. daily generalized convulsions ... | 1976 | 62652 |
| the identification of 3alpha,6beta,11beta,17,21-pentahydroxy-5beta-pregnan-20-one (6beta-hydroxy-thf)--the major urinary steroid of the baboon (papio papio). | 1976 | 827658 | |
| inhibition of reflex epilepsy by (+/-)-n-n-propylnorapomorphine. | in baboons, papio papio, spontaneously showing photosensitive epilepsy, myoclonic responses to intermittent photic stimulation were reduced or abolished for up to four hours by (+/-)-n-n-propylnorapomorphine (npa) 0.05-0.2 mg/kg body weight, given i.v. in animals pretreated with allyglycine, 200 mg/kg, a transient abolition of myoclonic responses followed npa, 0.2 mg/kg. in dba/2 mice, seizures following auditory stimulation were attenuated or abolished by npa 0.025-0.1 mg/kg given intraperitone ... | 1976 | 824145 |
| [action of ketamine of paroxysmal discharges provoked by air emboli in the baboon papio papio]. | ketamine was administered to 18 baboons (papio papio) to disrupt epileptic discharges elicited through intracarotid air injection. discharge suppression was obtained in all animals but could be preceded by a phase of enhancement of the epileptic patterns, which rendered necessary the injection of a supplementary dose. the mechanisms of ketamine action are discussed, in connection with data from the literature. some of the latter suggest that its use in proved epileptics facilitates paroxystic pa ... | 1976 | 60222 |
| effects of drugs modifying brain levels of catecholamines on photically induced epilepsy in papio papio. | the behavioral and electrographic effects of dl-amphetamine, disulfiram, fla-63, and propranolol on the photically induced epilepsy of the senegalese baboon were evaluated. amphetamine produced somatic hypokinesia with enhancement of eye movements, diminution of spontaneous paroxysmal activity, and little change in photosensitivity. the acute effects of disulfiram and fla-63 were poor, but the latter was lethal in the days following administration. propranolol showed no consistent effects. parti ... | 1976 | 976217 |
| measurement of anticonvulsant activity in the papio papio model of epilepsy. | the status of papio papio as a model of clinical epilepsy has been reviewed. the anticonvulsant effects of single doses of various classic and experimental agents have been compared against seizures induced in the p. papio by intermittent light stimulation. long-acting but not short-acting barbiturates have been shown fully to control seizures with minor sedative effects. diphenylhydantoin (in chronic doses only) and trimethadione are often effective but not consistently so. diazepam and clonaze ... | 1976 | 821787 |
| modifications and development of spinal reflexes in the alert baboon (papio papio) following an unilateral vestibular neurotomy. | unilateral vestibular neurotomy performed on 6 baboons was followed by the classical postural and locomotor postoperative disorders. postoperative spinal reflex excitability was studied in these awake baboons by measuring monosynaptic recruitment ratios in soleus motoneuronal pool and the recovery cycle of the monosynaptic response. vestibular neurotomy induces: (1) asymmetrical spinal reflexes with a decrease of the recruitment on the side of the section and an increase on the opposite side. (2 ... | 1976 | 821586 |
| the metabolic clearance rates and interconversion of cortisol and cortisone in pregnant and nonpregnant baboons. | pregnancy alters the pattern of maternal cortisol (f) metabolism and increases the maternal serum cortisol-binding capacity (cbc) of baboons. to determine whether these changes are associated with alterations in f clearance,the metabolic clearance rate (mcr) and interconversion (p) of f and cortisone (e) were measured by continuous infusion of (3h)f and (14c)e in 9 regularly menstruating and 7 pregnant baboons (papio papio). in nonpregnant animals, the values (x +/- se) for mcr-e (488 +/- 48 1/d ... | 1976 | 954656 |
| [differences in distribution of type i and type ii collagens in the superficial and intermediary zones of articular cartilage]. | undecalcified frozen sections, 40 mu thick, were cut from the knee articular cartilage of young adult baboons (papio papio). the sections were freeze dried and the superficial and the intermediate zones were separated by microdissection under a binocular dissecting microscope. the material of each zone was cleaved with cnbr and the major peptides were analyzed by discelectrophoresis in sds polyacrylamide. peptides alpha, cb 3,5 and alpha, (ii) cb 10 were used as characteristic markers for type i ... | 1976 | 825275 |
| spontaneous recurrent seizure state induced by daily electric amygdaloid stimulation in senegalese baboons (papio papio). | daily electrical stimulation of the amygdala in senegalese baboons (papio papio) resulted in the development of generalized convulsive seizures focal onset through five distinct clinical stages in an average of 72 days. the chronologic pattern of electroclinical features suggested that vertical intrahemispheric ictal dissemination was of primary importance in the progressive seizure development. some animals developed spontaneous recurrence of both partial complex and primary generalized seizure ... | 1976 | 814482 |
| [frontal cerebral cortex and photic epilepsy of the baboon papio papio (author transl)]. | it was discovered in 1966 that the senegalese baboon (papio papio) exhibits a photosensitive epilepsy. this finding has led, among other work, to the neurophysiological study of this epilepsy. although in some characteristics the baboon's photosensitive epilepsy differs from that of man, it can be considered that this animal presents a real model of essential epilepsy, for the study of the human disease. 2. in the baboon, the eeg disturbances triggered by intermittent light stimulation at 25 hz ... | 1976 | 819647 |
| metabolic clearance and production rates of progesterone in non-pregnant and pregnant baboons (papio papio). | the metabolic clearance rate (mcr) of progesterone was examined in the baboon to determine whether the increased serum progesterone concentrations during gestation result from increased production or decreased clearance. mcr was determined by constant infusion of [3h]progesterone in 6 non-pregnant baboons and 13 pregnant animals, between 58 and 175 days gestation. progesterone mcr (mean+/-se) was significantly greater in pregnant (1316+/-105 1/day, p less than 0.025; 87.3 +/- 6.2 1/day/kg, p les ... | 1976 | 825366 |
| the metabolism of cortisol by term baboon neonates (papio papio). | the metabolism of iv administered (4-14c)cortisol (f) was examined in 3 female, spontaneously delivered, term baboons less than 24th old. sixty and 80% of 14c was recovered in urine within 24 and 68 h,respectively. the distribution of urinary 14c was 44.7% unconjugated, 18.1% glucuronoside, 3.3% sulfate, and 24% unextractable with ethyl acetate. the metabolites were isolated by chromatography and crystallization. eight per cent of unconjugated and 60% of glucuronoside metabolites were more polar ... | 1976 | 954646 |
| type c viruses from kirsten sarcoma-transformed mink cells co-cultivated with primate cells and expressing p30 antigens related to feline leukemia virus. | two type c viruses with new antigenic and biological properties were isolated by co-cultivating secondary cell strains established from the kidneys of a baboon (papio papio) and a patas monkey (erythrocebus patas) with mink cells non-productively transformed by kirsten sarcoma virus. both new isolates (designated pp-1r and ep-1r) contain major structural proteins (p30) that are immunologically most closely related to the p30 proteins of feline leukemia viruses. the reverse transcriptases of both ... | 1976 | 60495 |
| [an electrophysiological study of direct occipito-frontal connections in centrum semi-ovale of papio papio]. | 1. evoked responses to single visual stimuli (vep) and driving by intermittent light stimulation (ils) were recorded with macroelectrodes from the central white matter (centrum semiovale) of 12 papio papio baboons. 2. two types of vep were identified: veps with constant morphology, localized in the long associative bundles connecting the occipital, temporal and frontal lobes; veps with variable morphology and without any preferential localization; these probably originate from other types of fib ... | 1975 | 45946 |
| the sleep of the baboon, papio papio, under natural conditions and in the laboratory. | the sleep pattern of sixteen baboons (papio papio) was studied under two very different conditions: (1) in a laboratory at marseilles, the monkey being immobilized in a restraining chair in a soundproof cubicle; (2) in an african reserve, the monkey being housed in a large cage placed in its natural environment. some very marked differences emerged. sleep in the laboratory was longer (by 24 min) and richer in stage 3 and paradoxical sleep. in africa, however, the sleep showed much more stage 1, ... | 1975 | 53145 |
| neurophysiology of photically induced epilepsy in papio papio. | this chapter critically reviews arguments supporting the role of the frontal cortex in light-sensitive epilepsy of the baboon papio papio in the light of the most recent neurophysiological research. in particular, it is known that spontaneous or ils-induced paroxysmal discharges, as well as generalized seizures, originate in the frontorolandic cortical region. in this region during ils, neurons behave in the same manner as hyperexcitable neurons in focal epileptogenic lesions of animals and man. ... | 1975 | 1146641 |
| excessive light sensitivity in papio papio: its variation with age, sex, and geographic origin. | excessive sensitivity (levels 3 and 4) in a population of 1,122 papio papio was related with age, sex, and geographical origin. (1) age. there was no clinical response to intermittent light stimulation under the age of 5 months. these was no difference between animals 6 months to 2 years (j1) and those aged 2 to 4 years (j2). adult females were less often light sensitive (levels 3 and 4 = 32.9%) than immature females (52.4%). adult males could usually not be tested, but were probably less often ... | 1975 | 1149713 |
| recurrent spontaneous seizure state induced by prefrontal kindling in senegalese baboons, papio papio. | in our earlier study of amygdaloid kindling in papio papio (pp), the development of partial complex seizure and of focal motor seizure was correlated with bifrontal theta discharge and increasing rolandic spike discharge respectively and the final stage was characterized by primary generalized convulsive seizure. since the latter seizure pattern is known to originate from the frontal focus in man, the frontal cortex became suspect in the development of the final stage seizure pattern. daily pref ... | 1975 | 1201534 |
| [effect of cannabis on learning in the cynocephalic monkey (papio papio)]. | chronic treatment of monkeys with cannabis reduce the speed of acquisition of learned behavior, yet, learning is nevertheless possible. after acquisition, cannabis administration disturb the responses in the learning test. in this two experimental procedures, tolerance occurs to the effects of cannabis. | 1975 | 126742 |
| polymorphism of the ca-i locus of carbonic anhydrase in baboon. | polymorphism of erythrocytic carbonic anhydrase was studied by means of the usual technique of starch gel electrophoresis in papio papio, papio hamadryas, papio cynocephalus and papio anubis. in a sample containing both papio cynocephalus and papio anubis, examples of the homozygote ca-ib/ca-ib were found. a study of parental transmission established the ca-ib allelic form. | 1975 | 804560 |
| [generic characteristics and specific characteristics of the ponto-geniculo-occipital spike activity (pgo) in 2 baboons, papio hamadryas and papio papio]. | 1975 | 167907 | |
| [evolution of visual evoked responses during various states of vigilance in papio papio (author's transl)]. | averaged evoked responses (aer) to light flashes were recorded in baboons (papio papio) during wakefulness, slow-wave sleep and rapid eye movement (rem) periods, at the visual cortex, retrocalcarine sulcus, optic tract (ot), lateral geniculate (lg) and pulvinar. waking aers were composed: in the ot, of a negative, low amplitude wave at 13.3 msec (i), a high amplitude wave at 34.8 msec (ii), a negative wave at 72 msec (iii) and a late component at 151 msec; in the lg, a small positive wave (ii) w ... | 1975 | 172195 |
| proceedings: spontaneous spike and wave with anterior distribution in association with fits induced by photic stimulation in papio papio. report of a case. | 1975 | 52534 | |
| effects of tetrahydrocannabinols on kindled amygdaloid seizures and photogenic seizures in senegalese baboons, papio papio. | intraperitoneal injections of delta 8-tetrahydrocannabinol (thc) and delta 9-thc failed to affect myoclonic response to photic stimulation in senegalese baboons (papio papio). however, both isomers of thc exerted dose-related antiepileptic effects upon established kindled convulsions provoked by electrical stimulation of amygdala in the same species. delta 9-thc was more potent than delta 8-thc, in terms of both antiepileptic effects and general toxicity. the antiepileptic effects of the thc iso ... | 1975 | 810346 |
| photically induced epilepsy in papio papio as a model for drug studies. | neurophysiological studies employing drugs have been undertaken in the natural syndrome of photically induced epilepsy in the senegalese baboon papio papio. gaba-mediated inhibition, both pre- and posysynaptic, plays an important role in the epileptic manifestations seen in this syndrome synapses can significantly modify photically induced epileptic responses, partly as a result of changes in afferent activity. the level of activity in dopaminergic systems can also modify the epileptic signs. am ... | 1975 | 1170711 |
| a primate model for testing anticonvulsant drugs. | senegalese baboons (papio papio), with a natural syndrome of photosensitive epilepsy, consistently show generalized myoclonic jerks if stimulated stroboscopically at hourly intervals, two to eight hours after the intravenous administration of allylglycine, 200 mg/kg. this provides a model for testing the acute antiepileptic effects of established or new drugs. the relationship between concentration of drug, antiepileptic action, and acute neurological toxic effects can be studied. pnehobarbital ... | 1975 | 237498 |
| electroencephalographic effects of fenfluramine and norfenfluramine in the baboon, papio papio. | 1975 | 809780 |