Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| the antioxidant effects of aqueous and organic extracts of panax quinquefolium, panax notoginseng, codonopsis pilosula, pseudostellaria heterophylla and glehnia littoralis. | the roots of panax quinquefolium, panax notoginseng, glehnia littoralis, codonopsis pilosula and pseudostellaria heterophylla were extracted with an aqueous extraction method and also with an organic extraction method. the aqueous extracts of glehnia littoralis and codonopsis pilosula were the most potent in inhibiting erythrocyte hemolysis. the aqueous extracts of panax quinquefolium and panax notoginseng had lower potencies while the aqueous extract of pseudostellaria heterophylla and the orga ... | 2004 | 15234766 |
| liquid chromatographic method for determination of four active saponins from panax notoginseng in rat urine using solid-phase extraction. | four major active saponins (ginsenosides rg1, rb1, rd and notoginsenoside r1) in panax notoginseng were determined in rat urine after oral and intravenous administration of total saponins of p. notoginseng (pns), and the urine samples were treated with solid-phase extraction (spe) prior to liquid chromatography. a reversed-phase liquid chromatography system with ultraviolet detection and a zorbax sb-c18 column was used. the within-day and between-day assay coefficients of variation for the four ... | 2004 | 15261811 |
| scale-up of centrifugal impeller bioreactor for hyperproduction of ginseng saponin and polysaccharide by high-density cultivation of panax notoginseng cells. | scale-up of a novel centrifugal impeller bioreactor (cib) was demonstrated for production of valuable plant-specific secondary metabolites by high-density cell cultures. initial kla was identified to be a key factor affecting cell growth and production of ginseng saponin and polysaccharide by high-density cultivation of panax notoginseng cells in a 3-l cib. a high level of ginseng saponin and polysaccharide production was obtained at an initial kla value of 30.2 h(-1). a maximum dry cell weight ... | 2004 | 15296432 |
| total saponins of panax notoginseng protected rabbit iliac artery against balloon endothelial denudation injury. | to investigate whether total panax notoginseng saponins (pns) could protect endothelium of rabbit iliac artery against balloon endothelial denudation (bed) injury. | 2004 | 15339390 |
| adjuvant effect of panax notoginseng saponins on the immune responses to ovalbumin in mice. | in this study, the haemolytic activities of panax notoginseng saponins (pns) and its adjuvant potentials on the cellular and humoral immune responses of icr mice against ovalbumin (ova) were evaluated. we determined the haemolytic activity of pns using 0.5% rabbit red blood cell. pns showed a slight haemolytic effect, with its haemolytic percents being 11.59 and 3.60% at the concentrations of 500 and 250 microg/ml, respectively. furthermore, the adjuvant potential of pns at three dose levels on ... | 2004 | 15364435 |
| [effect of total saponins of panax notoginseng on transdifferentiation of rats' tubular epithelial cell induced by il-1alpha]. | to study whether total saponins of panax notoginseng (pns) can prevent renal interstitial fibrosis occurrence through blocking the il-1alpha induced tubular epithelial cell and decrease the secretion of extracellular matrix (ecm). | 2004 | 15366598 |
| hplc determination of four active saponins from panax notoginseng in rat serum and its application to pharmacokinetic studies. | four main active saponins (ginsenosides rg1, rb1, rd and notoginsenoside r1) in panax notoginseng in rat serum after oral and intravenous administration of total saponins of p. notoginseng (pns) to rats were determined using a simple and sensitive high-performance chromatographic method. the serum samples were pretreated with solid-phase extraction before analysis. the calibration curves for the four saponins were linear in the given concentration ranges. the intra-day and inter-day assay coeffi ... | 2004 | 15484230 |
| [effect of total panax notoginseng saponins on the activity of human endothelial nitric oxide synthase gene promoter]. | to study the mechanism of total panax notoginseng saponin (tpns) in regulating the transcription activity of human endothelial nitric oxide synthase (henos) gene promoter. | 2004 | 15485778 |
| [inhibiting effects of panax notoginseng extracts on proliferation of ges-1 cells and mnng-transformed ges-1 cells]. | through cell cultivation, we studied the inhibiting effects of the serum of the dog fed with panax notoginseng extracts on precancerous gastric cells, trying to find the best time points or periods when the extracts' function was the strongest after administration of the extracts to the dog. | 2004 | 15539025 |
| [isolation and identification of minor bioactive saponins from the leaves of panax notoginseng]. | the minor bioactive saponins of the total saponin from the leaves of panax notoginseng (burk.) f. h. chen. were separated and purified by column chromatographies on silica gel and thin layer gel. four compounds were identified as: ginsenoside c-k (i) [20 (s) -protopanaxadiol 20-o-beta-d-glucopyranoside], ginsenoside-rh1 (ii) [20 (s) -protopanaxatriol-6-o-beta-d-glucopyranoside], ginsenoside-mc (iii) [20 (s)-protopanaxadiol 20-o-alpha-l-arabinofuranosyl (1 --> 6) -d-glucopyranoside] and notoginse ... | 2004 | 15551962 |
| [the historical condition in the spread of sanqi (panax notoginseng) in the ming dynasty]. | a well-known and extensively applied chinese herbs for promoting blood circulation and resolving blood stasis, san qi (pana notoginseng) is one of the medicinal plants first applied by the minority ethnic groups in southwestern china originally grown in wenshan of yunnan and baise of guangxi, china. the doctors in inland china began to know and apply it in the ming dynasty, indicating that the spread of medicine is restricted and influenced not only by geographical positions but also by social e ... | 2004 | 15555246 |
| high-performance liquid chromatographic method with quantitative comparisons of whole chromatograms of raw and steamed panax notoginseng. | a high-performance liquid chromatographic (hplc) method coupled with chromatographic pattern matching was developed to differentiate whole chromatograms of raw and steamed panax notoginseng objectively and quantitatively. the major peaks differentiating chromatograms of raw and steamed samples were also identified for the first time in this herb. the raw and steamed p. notoginseng roots and its products were successfully differentiated. the quantitative differences between the chromatograms were ... | 2004 | 15584233 |
| [fingerprinting of panax notoginseng by high-performance liquid chromatography]. | fingerprinting of panax notoginseng was performed by high-performance liquid chromatography using agilent hypersil c18 (250.0 mm x 4.0 mm, 5 microm) column with the mobile phase of acetonitrile and water and gradient elution. the detection wavelength was set at 203 nm. the method is simple and reliable to identify and evaluate the quality of panax notoginseng. | 2004 | 15604072 |
| comparative study of the composition of tcm radix notoginseng extract samples before and after acetylation with uv and elsd detection. | to study the derivation, acetylation specifically, as well as the application of evaporative light-scattering detector (elsd) detection of panax notoginseng extract for a better understanding of its components, as well as to study the authentication of this traditional chinese medicine (tcm). | 2004 | 15605098 |
| [effects of lingfasu on embryoid and plantlet formation of panax notoginseng in vitro]. | on the medium ms added the right amount of 2,4-d and lfs (angustmycin) and cultured under dark condition, the callus from stem segments of panax notoginseng could induce a lot of embryoids. in 2-3 months, the ratio of embryoid formation reached about 90%. then transplanted on ms + 2,4-d 1.5 mg/l + lfs 2 mg/l and cultured under light 20001x, near 30% embryoids could grow and develop as robust plantlets. | 2004 | 15850351 |
| interactions of a herbal combination that inhibits growth of prostate cancer cells. | pc spes is an eight-component herbal product marketed for the treatment of prostate cancer. the manufacturer of pc spes claims that the herbal combination is a synergistic blend, but the purported synergy has never been tested. we examined the interaction in cell culture of these eight individual herbal components by the use of an isobologram. | 2004 | 15060741 |
| [clinical observation on effect of xuesaitong injection as auxiliary treatment of severe craniocerebral injury]. | to evaluate the effect of xuesaitong injection (xsti, a preparation of panax notoginseng) as auxilliary treatment of severe craniocerebral injury. | 2004 | 15074087 |
| [identification of panax notoginseng and its preparations by lc/ms]. | to develop a method of identifying the existing of panax notoginseng in products of traditional chinese medicine compound danshen. | 2004 | 15127621 |
| [effect of panax notoginseng saponin on procoagulant activity and differentiation induction in nb4 cells]. | to investigate the effect of panax notoginseng saponin (pns) on procoagulant activity (pca) and differentiation induction in nb4 cells. | 2004 | 14976894 |
| [experimental studies of panax notoginseng saponines and ginkgo biloba extracts on preventing acute oxygen toxicity]. | to investigate the preventive effects of panax notoginseng saponines (pns) and ginkgo biloba extracts (gbe) on acute oxygen toxicity and the possible mechanisms. | 2004 | 21166216 |
| [studies on formulations of panax notoginsenosides for intranasal administration]. | to develop high bioavailability preparations without irritation for panax notoginsenosides. | 2003 | 14992002 |
| [study on the anti-apopotosis induced by hypoxia/hypoglycemia and reoxygenation of panax notoginseng saponins in cultured rat hippocampal neurons]. | to study the inhibitory effects of panax notoginseng saponins(pns) on apoptosis induced by hypoxia/hypoglycemia and reoxygenation in cultured rat hippocampal neurons. | 2003 | 15015268 |
| [industrialization of medicinal plant tissue culture]. | compared with other countries, the industrialization of medicinal plant tissue culture is more important for our country because china is consuming and exporting the most amounts of herb materials in the world. each year, many papers and patents are published on cell cultures of popular medicinal plants, such as taxus sp., catharanthus roseus, and panax ginseng, and, meanwhile, the research on organ cultures of medicinal plants is increasing very quickly, which is deepening the study of medicina ... | 2003 | 15139118 |
| [fingerprint construction of panax notoginseng]. | to provide application and identification basis for panax notoginseng by constructing the hplc-fp of panax notoginsing. | 2003 | 15139137 |
| panax notoginseng (burk.) effects on fibrinogen and lipid plasma level in rats fed on a high-fat diet. | several studies have shown that notoginsenoides improve diastolic function in hypertensive subjects, induce the fibrinolytic system in in vitro models and act as antiproliferative agents on vessel leiomyocytes. our aim was to evaluate their effect on fibrinogen and lipid plasma levels compared with a well-known hmgcoa reductase inhibitor. seventy wistar male adult rats on a fat-enriched diet were treated orally with p. notoginseng pulverized root (43 mg/kg/day or 86 mg/kg/day; 20 animals per gro ... | 2003 | 12601683 |
| pharmacokinetics and bioavailability of ginsenoside rb1 and rg1 from panax notoginseng in rats. | panax notoginseng is used as a therapeutic agent to stop haemorrhages and a tonic to promote health in chinese medicine. currently saponins of p. notoginseng (pns) are especially given attentions for their hemorheological properties. the pharmacokinetic profiles of the main pns are still not accurately investigated. therefore, our preliminary aim is to elucidate the pharmacokinetic features of ginsenoside rb(1) (rb(1)) and ginsenoside rg(1) (rg(1)), two of the main pns in rats. firstly, quantiti ... | 2003 | 12648814 |
| liquid chromatography/mass spectrometry of malonyl-ginsenosides in the authentication of ginseng. | different negative ion electrospray (es) source conditions are required to concentrate the ion current in [m-h](-) for malonylated and non-malonylated ginsenosides. however, both can be ionised optimally in a single liquid chromatography/mass spectrometry (lc/ms) analysis by employing switchable voltages in the post-source ion optics of a quadrupole ion trap mass spectrometer. coupled with automatic ms/ms scanning and post-acquisition neutral loss data analysis, this method provides a means of p ... | 2003 | 12539190 |
| [effects of panax notoginseng saponins on the expression of tumor necrosis factor alpha and secretion phospholipase a2 in rats with liver fibrosis]. | 2003 | 12546751 | |
| [comparison of amino acid contents in panax notoginseng from different habitats]. | to determine the contents of amino acid and study the characters of sanqi (panax notoginseng) from different habitats. | 2003 | 12795215 |
| authentication of panax notoginseng by 5s-rrna spacer domain and random amplified polymorphic dna (rapd) analysis. | the great majority of panax species are well-known herbal medicines in the orient, and many of them share a close resemblance in appearance and chemical composition. among these panax species, the root of p. notoginseng (sanqi) is a unique herb that has distinct clinical usage. here, the 5s-rrna spacer domains were isolated from p. notoginseng, p. japonicus var. major, p. stipuleanatus, p. quinquefolius, p. ginseng, p. zingiberensis, and p. wangianus, and four common adulterants of p. notoginsen ... | 2003 | 12865989 |
| structures of new dammarane-type triterpene saponins from the flower buds of panax notoginseng and hepatoprotective effects of principal ginseng saponins. | the saponin fraction from the flower buds of panax notoginseng exhibited protective effect on liver injury induced by d-galactosamine and lipopolysaccharide. from the saponin fraction with hepatoprotective effect, five new dammarane-type triterpene saponins, notoginsenosides-o (1), -p (2), -q (3), -s (4), and -t (5), were isolated together with nine known protopanaxadiol oligoglycosides. the structures of the new saponins were elucidated on the basis of chemical and physicochemical evidence. the ... | 2003 | 12880307 |
| effects of panax notoginseng saponins on myocardial gsalpha mrna expression and atpase activity after severe scald in rats. | the aim of this study was to investigate the changes of myocardial gsalpha mrna expression and atpase and the effects of panax notoginseng saponins (pns) on that after burns in rats. wistar rats were exposed to a 95 degrees c water bath for 10s to produce 30% tbsa skin-full-thickness scalds. myocardial gsalpha mrna level, camp content and adenyl cyclase (ac) activities were determined with dot blotting hybridization, radioimmunoassay and indirect method, respectively. the atpase activities in pl ... | 2003 | 12927977 |
| isolation of dammarane saponins from panax notoginseng by high-speed counter-current chromatography. | the chinese phytomedicinal formulation sanqi zongdai pian, traditionally prepared from crude extracts from roots of panax notoginseng (araliaceae), contains highly polar dammarane saponins which were separated at a preparative scale using high-speed counter-current chromatography (hsccc). in each operation, 283 mg methanolic extract of five tablets was separated and yielded pure 157, 17, 13 and 56 mg of ginsenoside-rb1, notoginsenoside-r1, ginsenoside-re and ginsenoside-rg1, respectively, n-hexa ... | 2003 | 12967182 |
| studies on the interaction of total saponins of panax notoginseng and human serum albumin by fourier transform infrared spectroscopy. | total saponins of panax notoginseng (tpns), isolated from the roots of panax notoginseng (burk) f.h. chen, have been considered as the main active components of san-chi and have various therapeutical actions. their interactions with human serum albumin have been investigated by fourier transformed infrared spectrometry and fluorescence methods. the results showed that tpns combined with hsa through c=o and c-n groups of polypeptide chain. the drug-protein combination caused the significant loss ... | 2003 | 14499835 |
| analysis of saponins in raw and steamed panax notoginseng using high-performance liquid chromatography with diode array detection. | a reversed-phase high-performance liquid chromatography-diode array detection method was developed and validated for the simultaneous determination of six saponins (notoginsenoside r1, ginsenosides rg1, re, rb1, rc, rd) in raw and steamed panax notoginseng. linearity (r2 > 0.9988), intra- and inter-day precision (rsd < 4%), limit of detection (0.008-0.013 mg/ml), limit of quantification (0.027-0.042 mg/ml) of the saponins were determined. the method was successfully applied to 11 pairs of raw an ... | 2003 | 14518765 |
| [observation of blooming habits of panax notoginseng]. | this paper reported the whole process of blooming habits of panax notoginseng and pollens scattering regularities in wenshan, yunnan province. it can provide reference for the pollenation of hybridization. | 2003 | 14528688 |
| effects of san qi on gastric secretion and protective factors of gastric mucosa in the rat with precancerous lesion of stomach. | in the model rat with precancerous lesion of stomach induced by the combined method of insertion of a spring into the pylorus and high salt hot paste, effects of san qi ([symbol: see text] radix notoginseng) on gastric secretion and protective factors of stomach were investigated. the results indicated that gastric secretion, gastric mucosal blood flow (gmbf) and aminohexose content lowered significantly, and malondialdehyde (mda) increased significantly (p < 0.01) in the model group as compared ... | 2003 | 14535198 |
| protection by hot water extract of panax notoginseng on chronic ethanol-induced hepatotoxicity. | the purpose of this study was to investigate the antioxidant effects of a hot water extract of panax notoginseng (png) against chronic ethanol-induced hepatotoxicity. fifty mice were divided into fi ve equal groups with 10 in each group. group 1 (control) received saline, whereas group 2 received ethanol (70%, 0.1 ml, p.o.) once daily for 4 weeks, which induced hepatotoxicity, manifested biochemically by a significant elevation of serum enzyme activities, such as sgot and sgpt. hepatotoxicity wa ... | 2003 | 14595601 |
| haemolytic activities and immunologic adjuvant effect of panax notoginseng saponins. | to evaluate haemolytic activities and adjuvant effect of panax notoginseng saponins (pns). | 2003 | 14627501 |
| chemical assessment of roots of panax notoginseng in china: regional and seasonal variations in its active constituents. | root of panax notoginseng (radix notoginseng, sanqi) is a well-known traditional chinese medicine and is mainly cultivated in wenshan of yunnan, china. the active constituents include saponin, dencichine, flavonoid, and polysaccharide; however, the levels of these components vary in different geographical regions of growth and also show a seasonal variation. by using high-performance liquid chromatography and spectrophotometry, the contents of notoginsenoside r1, ginsenoside r(g1), r(b1), r(d), ... | 2003 | 14705886 |
| synthesis of oligosaccharide derivatives related to those from sanqi, a chinese herbal medicine from panax notoginseng. | oligosaccharide derivatives from sanqi, a chinese herbal medicine derived from panax notoginseng, methyl beta-d-galactopyranosyl-(1-->3)-[alpha-l-arabinofuranosyl-(1-->6)]-alpha-d-galactopyranoside, diosgenyl beta-d-galactopyranosyl-(1-->3)-[alpha-l-arabinofuranosyl-(1-->6)]-alpha-d-galactopyranoside, and methyl beta-d-galactopyranosyl-(1-->3)-[alpha-l-arabinofuranosyl-(1-->6)]-alpha-d-galactopyranosyl-(1-->4)-beta-d-galactopyranosyl-(1-->3)-[alpha-l-arabinofuranosyl-(1-->6)]-alpha-d-galactopyra ... | 2002 | 11890886 |
| a xylanase from roots of sanchi ginseng (panax notoginseng) with inhibitory effects on human immunodeficiency virus-1 reverse transcriptase. | a xylanase with a molecular weight of 15 kda, which is lower than those of previously reported xylanases, was isolated from the roots of the medicinal herb panax notoginseng. the xylanase exhibits a temperature optimum of 50 degrees c and a ph optimum between 5 and 6. it inhibits hiv-1 reverse transcriptase with an ic(50) of 10 microm, but does not affect translation in a cell-free rabbit reticulocyte system when tested up to 70 microm. the enzyme is adsorbed on cm-cellulose, affi-gel blue gel a ... | 2002 | 12138018 |
| estrogen-like activity of ginsenoside rg1 derived from panax notoginseng. | ginsenosides have demonstrated pharmacological effects in the central nervous, cardiovascular, and endocrine systems. we hypothesize that ginsenosides might mediate some of their actions by binding to the estrogen receptor, as they share many of the protective actions of estrogen in various physiological systems. the present study is aimed to determine whether ginsenoside rg1 can act like an estrogen analog in stimulating human breast cancer cell growth as well as in the activation of estrogen r ... | 2002 | 12161497 |
| pananotin, a potent antifungal protein from roots of the traditional chinese medicinal herb panax notoginseng. | the roots of the sanchi ginseng, panax notoginseng, were extracted with an aqueous buffer. the extract was chromatographed on a cm-cellulose column to remove extraneous unadsorbed proteins. the adsorbed fraction was dialyzed and chromatographed on affi-gel blue gel. the adsorbed fraction was again collected, dialyzed and applied on a column of mono s. the second peak was dialyzed and chromatographed on an fplc-gel filtration superdex 75 column. an antifungal protein with an n-terminal sequence s ... | 2002 | 12451495 |
| protective effects of trilinolein extracted from panax notoginseng against cardiovascular disease. | trilinolein is a triacylglycerol purified from a commonly used traditional chinese medicine panax notoginseng. trilinolein has been reported to provide a number of beneficial effects including reducing thrombogenicity and arrhythmias and increasing erythrocyte deformability. additionally, trilinolein has been reported to be an antioxidant, which can counteract free radical damage associated with atherogenesis, and myocardial damage seen with ischaemia and reperfusion. these pharmacologic effects ... | 2002 | 12466054 |
| [the research of technique of panax notoginseng seed coating for culturing seedlings]. | to screen seed coating formulation and to investigate culturing seedling technique for panax notoginseng (sanqi). | 2002 | 12685341 |
| [protective effects and its mechanism of panaxatriol saponins isolated from panax notoginseng on cerebral ischemia]. | to study the protective effects and its mechanism of panaxatriol saponins isolated from panax notoginseng (pts) on focal cerebral ischemia in rat brain. | 2002 | 12774330 |
| [effect of dan-shen, san-qi of different proportion on platelet aggregation and adhesion in normal rabbits]. | to observe the effect of the crude extracts of dan-shen root and san-qi of different proportion on platelet aggregation and adhesion in normal rabbits. | 2002 | 12776499 |
| [a review of adverse effects of panax notoginseng (burk.) f.h.chen]. | 2002 | 14748374 | |
| [saponins with low sugar chain from the leaves of panax notoginseng (burk) f. h. chen]. | six saponins with low sugar chain were isolated from the leaves of panax notoginseng (burk) f. h. chen. their structures were elucidated as 20(r)-ginsenoside rh2(i), 20(r)-ginsenoside rg3(ii), ginsenoside mc(iii), ginsenoside f1(iv), ginsenoside rh1(v) and daucosterol(vi) by spectroscopic analysis and comparison with authentic samples. compounds i-iv were first isolated from the plant. | 2002 | 12583159 |
| [seedling quality and root rot on panax notoginseng]. | the experiment was carried on the relationship between seedling quality and root rot on sanqi (panax notoginseng). the result showed that seedlings from new reclamation land, the root rot disease was fewer and existing rate of seedling was higher than that of seedlings from old gardenplot. therefore, selecting ill-free and robust seedling is one of important measure for the control of root rot on sanqi cultivation. | 2002 | 12583185 |
| [effect of panax notoginseng saponins on human kidney fibroblast]. | to study the effect of panax notoginseng saponins (pns) on cell proliferation, type i collagen secretion and integrin beta 1 expression in human kidney fibroblast (kfb). | 2002 | 12585173 |
| manipulation of ginsenoside heterogeneity in cell cultures of panax notoginseng by addition of jasmonates. | manipulation of the heterogeneity of ginsenosides with different pharmacological activities was attempted by adding methyl jasmonate (mja) or dihydro-methyl jasmonate (hmja) to suspension cultures of a high-saponin-producing cell line of panax notoginseng. compared with hmja, mja not only increased ginsenoside content to a large degree but also significantly altered the ratio of rb to rg groups of ginsenosides. the ginsenoside rd was not detected in either control cultures (without mja addition) ... | 2002 | 16233164 |
| effect of bottom clearance on performance of airlift bioreactor in high-density culture of panax notoginseng cells. | a fed-batch cultivation of panax notoginseng cells in a concentric-tube airlift reactor was performed to study the effects of bottom clearance on cell growth and the production of ginseng saponin and polysaccharide. at a bottom clearance of 4.0 cm, the highest cell density of 29.1+/-1.6 g/l by dry weight was obtained, and the accumulation of saponin and polysaccharide also reached a maximum, i.e., 2.39+/-0.43 and 2.73+/-0.40 g/l, respectively. cell growth and metabolite production were limited a ... | 2001 | 16233116 |
| sensitization of a tumor, but not normal tissue, to the cytotoxic effect of ionizing radiation using panax notoginseng extract. | the aim of the present study was to investigate any sensitization effect of the panax notoginseng extract (pne) and the purified saponin (rb1) on the radiation response of an experimental tumor (kht sarcoma) in mice, in comparison with any effects on a normal tissue (bone marrow). pne at a concentration of 0.1-100 mg/kg produced an increase in tumor radiosensitivity. the sensitization effect was maximal at 10 mg/kg and at 30 minutes after injection. higher doses were toxic to the bone marrow ste ... | 2001 | 11789595 |
| a validated method for quantitative determination of saponins in notoginseng (panax notoginseng) using high-performance liquid chromatography with evaporative light-scattering detection. | a gradient high-performance liquid chromatographic (hplc) method with evaporative light-scattering detection (elsd) for the determination of major saponins in a chinese traditional herbal medicine, panax notoginseng, is described. samples were analysed by means of a reverse-phase column (waters spherisorb ods-2, c-18) using acetonitrile and water under gradient conditions as the mobile phase over 60 min. the elsd used was set at an evaporating temperature of 35 degrees c and pressurized air pres ... | 2001 | 11804394 |
| [identification of notoginseng(panax notoginseng) and its adulterants using dna sequencing]. | to analyze the nuclear ribosomal rna small subunit (18s rrna) and chloroplast matk gene sequence of notoginseng (panax notoginseng) in order to provide molecular evidence for its genuine origin identification. | 2001 | 11563185 |
| improvement of panax notoginseng cell culture for production of ginseng saponin and polysaccharide by high density cultivation in pneumatically agitated bioreactors. | a panax notoginseng cell culture was successfully scaled up from shake flask to 1.0-l bubble column reactor and concentric-tube airlift reactor. high-density bioreactor batch cultivation was carried out using a modified ms medium. the maximum cell density in batch cultures reached 20.1, 21.0 and 24.1 g/l in the shake flask, bubble column and airlift reactors, respectively, and their corresponding biomass productivity was 950, 1140 and 1350 mg/(l x d) for each. the productivity of ginseng saponin ... | 2001 | 11587572 |
| bioactive saponins and glycosides. xix. notoginseng (3): immunological adjuvant activity of notoginsenosides and related saponins: structures of notoginsenosides-l, -m, and -n from the roots of panax notoginseng (burk.) f. h. chen. | new dammarane-type triterpene saponins, notoginsenosides-l, -m, and -n, were isolated from the glycosidic fraction of the dried roots of panax notoginseng (burk.) f. h. chen. their structures were elucidated on the basis of chemical and physicochemical evidence. immunological adjuvant activities of the principal notoginsenosides and related dammarane-type triterpene saponins were examined and notoginsenosides-d, -g, -h, and -k were found to increase the serum igg level in mice sensitized with ov ... | 2001 | 11724237 |
| effects of hepatocyte growth-promoting factor and panax notoginseng saponins on intrasplenic hepatocellular autotransplantation. | to increase the weight of liver tissue mass present in spleen and to shorten the regeneration period of transplanted hepatocytes by stimulating dna synthesis and protection against ischemic-reperfusion injury. | 2001 | 11743884 |
| [studies on saponin accumulative in regularities panax notoginseng (burk) f. h. chen]. | to determine the optimal harvest time for p. notoginseng through studying the changes of saponin contents with growth periods. | 2001 | 12525115 |
| isolation of a small chitinase-like antifungal protein from panax notoginseng (sanchi ginseng) roots. | an antifungal protein, with a molecular weight of 15 kda and an n-terminal sequence analogous to those of chitinases, was first isolated from the chinese medicinal material panax notoginseng, using cation exchange chromatography and affinity chromatography. the protein was adsorbed on cm-cellulose, affi-gel blue gel and mono s. it exerted antifungal activity against coprinus comatus, fusarium oxysporum and mycosphaerella arachidicola but not against rhizoctonia solani. the protein was devoid of ... | 2001 | 11311860 |
| effects of ginsenoside rb2 and rc on inferior human sperm motility in vitro. | the purpose of the study was to investigate the effects of two constituents of panax notoginseng flower extract, ginsenoside rb2 and rc, on human sperm motility and progression in vitro. semen samples were collected from 20 patients with sperm motility between 20% and 40% of normal. all samples had sperm counts of over 20 million per milliliter, in accordance with the world health organization standard. sperm were separated by a percoll discontinuous gradient technique, and divided into a percol ... | 2001 | 11321473 |
| isolation of a novel thermolabile heterodimeric ribonuclease with antifungal and antiproliferative activities from roots of the sanchi ginseng panax notoginseng. | an isolation procedure, consisting of ion exchange chromatography on cm-sepharose, affinity chromatography on affi-gel blue gel, and fast protein liquid chromatography on mono s, was utilized to purify a base-nonspecific, heterodimeric ribonuclease (rnase) with diverse activities from roots of the sanchi ginseng panax notoginseng. the rnase is unique in that it consists of two different nonglycoprotein subunits with a molecular weight of 27 and 29 kda, respectively. the latter subunit is charact ... | 2001 | 11444859 |
| panax notoginseng saponins attenuated cisplatin-induced nephrotoxicity. | to study protective effects of panax notoginseng saponins (pns) against cisplatin-nephrotoxicity. | 2000 | 11324427 |
| the ameliorating effects of the cognitive-enhancing chinese herbs on scopolamine-induced amnesia in rats. | ameliorating effects were investigated of the cognitive-enhancing chinese herbs administered orally for 1 week-panax ginseng (pg), panax notoginseng (png), dioscorea opposita (do), gastrodia elata (ge), salvia miltiorrhiza (sm), acorus gramineus (ag), coptis chinensis (cc), polygonum multiflorum (pm), cyperus rotundus (cr) and psoralea corylifolia (pc)-on the scopolamine (scop)-induced amnesia by using a passive avoidance task in rats. of ten chinese herbs, only pg, png, ge and cc prolonged the ... | 2000 | 10925408 |
| ustoo pc-spes surveys: review of studies and update of previous survey results. | in 1997, we resolved to survey ustoo members and other men known at that time to be taking pc-spes, a chinese herb combination that contains eight herbs: chrysanthemum, dyers woad, licorice, reishi, san-qi ginseng, rabdosia, saw palmetto, and baikal skullcap. the survey showed positive results, with respondents experiencing a decline in serum prostate specific antigen (psa), most to the undetectable range. of these patients, 88% maintained a low psa concentration, whereas 12% had a rise from nad ... | 2000 | 11062386 |
| orally administered panax notoginseng influence on rat spontaneous behaviour. | panax notoginseng root is highly prized in china for its supposed hemorheological properties. its behavioural effects are still not scientifically investigated; therefore, our preliminary study aim is to evaluate the influence of this phyto-drug on rats spontaneous behaviour. high quality p. notoginseng root dry extract has been orally administered through gastric tube for 10 days in two doses (43 and 86 mg/kg in a volume of 5 ml/kg per day) and its effects on locomotion, emotional reactivity an ... | 2000 | 11090991 |
| genetic heterogeneity of ribosomal rna gene and matk gene in panax notoginseng. | previously, 185 ribosomal rna gene and matk gene sequences of chinese herbal medicines, ginseng radix, panacis japonici rhizoma and panacis quinquefolli radix were shown to correspond with those of the original plants, panax ginseng, p. japonicus and p. quinquefolius, respectively, with the species-specific sequences especially for 18s rrna gene sequences. in p. notoginseng and its derivative, notoginseng radix, however, we found two genetic groups with respect to both gene sequences. five base ... | 2000 | 11105576 |
| effects of panax notoginseng saponins on vascular endothelial cells in vitro. | to investigate the inhibition of endothelium-dependent in vitro vascular relaxation induced by the total saponins (gensenosides) from panax notoginseng (pns) and the effect of pns on the cytosolic ca2+ concentration on cultured bovine pulmonary artery endothelial cells. | 2000 | 11603283 |
| [effect of panax notoginseng saponins combined isovolumic haemodilution on the retinal microcirculation of patients with retinal vein occlusion]. | to study the effect of panax notoginseng saponins (pns) or isovolumic haemodilution (ihd) and combination of pns with ihd on retinal microcirculation of patients with retinal vein occlusion (rvo). | 2000 | 12206008 |
| [determination of organochlorine pesticide multi-residues in astragalus membranaceus (fisch.) bge. var. mongholicus (bge.) hsiao, panax notoginseng (burk.) f. h. chen and p. quin quefolium l]. | to determine 15 organochlorine pesticide residues in astragalus membranaceus, panax notoginseng and p. quinquefolium. | 2000 | 12515220 |
| [studies on initial infection sources and channels of black spot on panax notoginseng (burk.) f.h. chen]. | to probe into the occurring and developing regularities of black spot on panax notoginseng for disease control. | 2000 | 12516450 |
| [effects of cultivating measures on root rot of panax notoginseng]. | to probe into the effects of cultivating measures on root rot of panax notoginseng for the integrate control. | 2000 | 12575264 |
| [effect of panax notoginseng saponin on ca2+, cam in craniocerebral injury]. | to explore the change of nerve cell ca(2+)-overload, ca(2+)-cam and the effect of panax notoginseng saponin (pns) on it in craniocerebral injury. | 1999 | 11783273 |
| [cerebral protective effects of some compounds isolated from traditional chinese herbs]. | to study the cerebral protective effects of some compounds isolated from traditional chinese herbs. | 1999 | 12205950 |
| [effects of rg1 on calcium channel of guinea pig ventricular myocytes]. | to evaluate the effect of rg1 (purified saponin of panax notoginseng) on l-ca2+ channel of guinea pig ventricular myocytes. | 1999 | 12205963 |
| [application study of yangkang biological fertilizer on panax notoginseng cultivation]. | yangkang biological fertilizer was sprayed on panax notoginseng. the result indicated that the yield and the surviving rate can be raised 25.2% and 15.2% respectively. the best spraying practice were: in the unfolding stage of leaves (april) and bloom stage (july), with yangkang biological fertilizer plus water (1:400), at four times every stage. | 1999 | 12571908 |
| [analysis of the vestiges of farm chemicals for panax notoginseng]. | the vestiges of farm chemicals in panax notoginseng plants and medicinal materials from main production areas in wenshan district was analyzed in this study. the result showed that the samples from the places contained hexachloro-cyclohexane and ddt. and the vestiges of hexachloro-cyclohexane was about 0.016-0.101 mg/kg, that of ddt was about 0.15-0.143 mg/kg. the content of cu, zn, pb, cd was lower than national standard of p. r. c. | 1999 | 12575102 |
| improvement of early postburn cardiac function by use of panax notoginseng and immediate total eschar excision in one operation. | cardiac dysfunction development in the early stage postburn has been an important problem in burn treatment. however, no effective therapies are available for use in clinical practice. in this study, we sought to determine whether early total eschar excision (eee) in one operation and the traditional chinese herb panax notoginseng (pns) would be helpful in improving early postburn cardiac function. 160 wistar rats were randomly divided into burn (burn group, n = 50), burn treated with eee (eee g ... | 1999 | 10090382 |
| effect of panax notoginseng extracts on inferior sperm motility in vitro. | the purpose of this study was to investigate the effects of panax notoginseng extracts on inferior sperm motility in vitro. semen samples were collected from 23 patients with sperm motility between 20% and 40%. the sperm count was over 20 x 10(6)/ml in accordance with the world health organization standard. 1.0 mg/ml and 2.0 mg/ml of panax notoginseng extracts including aqueous extract, n-butanol extract, and polysaccharide fraction on sperm motility and progression were evaluated by computer as ... | 1999 | 10354824 |
| effects of four herbal extracts on adjuvant-induced inflammation and hyperalgesia in rats. | to evaluate the effects of four herbal medicine extracts on a rat model of inflammatory hyperalgesia. design/interventions: inflammation was induced by injecting complete freund's adjuvant (cfa) into one hindpaw of each rat. four herbs that are routinely prescribed in traditional chinese medicine for treatment of pain were used: duhuo (radix angelicae pubescentis), bai jiang cao (patriniae herba cum radice), yan hu suo (rhizoma corydalis) and sanqui (panax notoginseng). the crude water extracts ... | 1999 | 10537242 |
| anti-carcinogenic activity of the roots of panax notoginseng. ii. | the extract of the roots of panax notoginseng (araliaceae) exhibited a significant anti-tumor-promoting activity on two-stage carcinogenesis of mouse skin tumors induced by 7,12-dimethylbenz[a]anthracene (dmba) as an initiator and a mycotoxin, fumonisin b1, as a non-12-o-tetradecanoylphorbol-13-acetate (non-tpa) type promoter. further, the extract exhibited the anti-tumor-initiating activity on two-stage carcinogenesis of mouse skin tumors induced by a nitric oxide donor, (+/-)-(e)-methyl-2-[(e) ... | 1999 | 10549877 |
| anti-inflammatory effects of total saponins of panax notoginseng. | to study the anti-inflammatory effects of total saponins of panax notoginseng (pns). | 1999 | 10678152 |
| extracellular ca2+ regulates the respiratory burst of human neutrophils. | the role of extracellular calcium in the activation of respiratory burst in human neutrophils was studied by using the receptor agonist, n-formyl-methionyl-leucyl-phenylalanine (fmlp), and the activator of protein kinase c phorbol myristate acetate (pma). the level of intracellular free calcium was measured by using both cell suspensions and single cells in the presence and absence of extracellular calcium. the ca2+-atpase inhibitor, thapsigargin, was used to activate higher ca2+ influx, while a ... | 1998 | 9739175 |
| [comparative study on effect of panax notoginseng and ticlid in treating early diabetic nephropathy]. | to explore the ameliorative effect and mechanism of panax notoginseng (png) and ticlid in treating early diabetic nephropathy (dn). | 1998 | 11475719 |
| [studies on control of root rot on panax notoginseng]. | chemical control tests of pot, plot and field for panax notoginseng root rot were conducted during 1995-1996. the results indicated that the chemical control is a effect measure to control rapidly occurring and spreading of panax notoginseng root rot. it was the best treatment to coordinate use of bactericide and fungicide, obviously better than alone or mixed use of fungicide and also better than alone use of bactericide. in the pot and plot tests, the best coordinate treatment was the treatmen ... | 1998 | 12567944 |
| [influence of seedling assortment on panax notoginseng growth and yield]. | making panax notoginseng seedling assortment according to seedling size before transplanting, the result shows that the influence is better, the yield of root tuber and fruit is higher. culturing good seedling is the fundamental measure to increase yield of p. notoginseng. | 1998 | 12567972 |
| [effect of total saponins of panax notoginseng (tspns) on myocardial intracellular ca2+ and activity of calcium pump of membrane of sarcoplasmic reticulum in shr]. | a comparative study was conducted on the action of tspns, ns and captopril in treating shr, with wky of similar ages taken as normal control. the results demonstrate that tspns helps increase the effect of calcium pump on the membrane of sarcoplasmic reticulum, decrease the myocardial intracellular ca2+ and reduce the mass of the left ventricular muscle. | 1998 | 11596240 |
| [relationship between root rot on panax notoginseng burk. f. h. chen and its environmental conditions]. | to probe into the relationship between root rot on panax notoginseng and its environmental conditions for integrate control of the disease. | 1998 | 12242819 |
| [observation of therapeutic effect by combined administration of salvia miltiorrhiza, ligustrazine and panax notoginseng on late hemorrhagic shock of rabbits]. | to explore the therapeutic mechanism of salvia miltiorrhize, ligustrazine and panax notoginseng in treating late hemorrhagic shock in rabbit. | 1997 | 9863115 |
| effect of saponins of panax notoginseng on synaptosomal 45ca uptake. | to explore the calcium uptake antagonism of saponins of panax notoginseng (pns). | 1997 | 10072935 |
| [clinical and experimental study of improving left ventricular diastolic function by total saponins of panax notoginseng]. | to investigate the effect of total saponins of panax notoginseng (tspns) on left ventricular diastolic function in patients with essential hypertension (eh) and possible mechanism. | 1997 | 10322816 |
| bioactive saponins and glycosides. viii. notoginseng (1): new dammarane-type triterpene oligoglycosides, notoginsenosides-a, -b, -c, and -d, from the dried root of panax notoginseng (burk.) f.h. chen. | the glycosidic fraction from the dried roots of panax notoginseng (burk.) f.h. chen was found to show protective effect on liver injury induced by d-galactosamine and lipopolysaccharide. from the glycosidic fraction with hepatoprotective effect, nine new dammarane-type triterpene oligoglycosides, notoginsenosides-a, -b, -c, -d, -e, -g, -h, -i, and -j and an acetylenic fatty acid glycoside, notoginsenic acid beta-sophoroside, were isolated together with fourteen known dammarane-type triterpene ol ... | 1997 | 9214709 |
| effect of notoginsenoside r1 on the synthesis of components of the fibrinolytic system in cultured smooth muscle cells of human pulmonary artery. | we have previously reported that notoginsenoside r1 (ng-r1) increases the synthesis of tissue-type plasminogen activator (t-pa) and decreases plasminogen activator inhibitor-1 (pai-1) activity in cultured human endothelial cells from different vascular sources. it was the aim of this study to investigate whether the effect of ng-r1 on the synthesis of components of the fibrinolytic system is also operative in another cell type of the blood vessel wall, the smooth muscle cell. therefore cultured ... | 1997 | 9220151 |
| [progress in the study on protective effect of saponins panax notoginseng on ischemic brain damage]. | 1996 | 9387754 | |
| immunostimulating polysaccharides from panax notoginseng. | the main purpose of this study is to prepare and characterize polysaccharides from panax notoginseng, investigate their effects on immune system in vitro in order to find new immunostimulants for the prevention and supporting treatment of infection and immunodeficiency related diseases. | 1996 | 8865311 |
| studies on the neuroexcitotoxin beta-n-oxalo-l-alpha,beta-diaminopropionic acid and its isomer alpha-n-oxalo-l-alpha,beta-diaminopropionic acid from the root of panax species. | the neuroexcitotoxic nonprotein amino acid, beta-n-oxalo-l-alpha,beta-diaminopropionic acid (beta-n-odap) was found in panax species such as panax ginseng 'c.a. meyer' (cultivated in northeastern china), panax quinquefolius (l), panax notoginseng 'f.h. chen' (cultivated in southwestern china), korean red ginseng and jilin (china) red ginseng. beta-n-odap was verified to be a natural substance, and its isomer alpha-n-oxalo-l-alpha,beta-diaminopropionic acid (alpha-n-odap) is very likely an artifa ... | 1996 | 8907498 |
| vascular effects of selected antihypertensive drugs derived from traditional medicinal herbs. | 1. the pharmacological actions of the active ingredients extracted or purified from two selected traditional chinese medicinal plants on vascular smooth muscles are briefly reviewed. the active ingredients of these herbal drugs include tetrandrine (tet) and total ginseng saponins (tgs). these natural products have been clinically used in china for the treatment of cardiovascular diseases due to their vasodilatory and antihypertensive actions. 2. studies from this laboratory have confirmed previo ... | 1995 | 9072399 |
| effects of panax notoginseng saponins on posthypoxic cell damage of neurons in vitro. | to study cerebral protective mechanism of panax notoginseng saponins (pns). | 1995 | 8701752 |