Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| kaposi's sarcoma-associated herpesvirus-encoded microrna mir-k12-11 attenuates transforming growth factor beta signaling through suppression of smad5. | kaposi's sarcoma-associated herpesvirus (kshv) encodes 12 pre-micrornas (pre-mirnas). current studies have shown that these mirnas are involved in regulation of viral and host gene expression, implicating a role in the maintenance of viral latency and suppression of antiviral innate immunity. however, the functions of these mirnas remain largely unknown. on the basis of the sequence homology between oncogenic mir-155 and kshv-encoded mir-k12-11, we hypothesized that mir-k12-11 could attenuate tr ... | 2011 | 22013049 |
| histone modifications in herpesvirus infections. | in eukaryotic cells, gene expression is not only regulated by transcription factors but also by several epigenetic mechanisms including post-translational modifications of histone proteins. there are numerous histone modifications described to date and methylation, acetylation, ubiquitination and phosphorylation are amongst the best studied. in parallel, certain viruses interact with the very same regulatory mechanisms, hereby manipulating the normal epigenetic landscape of the host cell, to fit ... | 2011 | 22188068 |
| Breach of the nuclear lamina during assembly of herpes simplex viruses. | Beneath the inner nuclear membrane lies the dense meshwork of the nuclear lamina, which provides structural support for the nuclear envelope and serves as an important organizing center for a number of nuclear and cytoplasmic constituents and processes. Herpesviruses have a significant and wide-ranging impact on human health, and their capacity to replicate and cause disease includes events that occur in the host cell nucleus. Herpesviruses begin assembly of progeny virus in the nuclei of infect ... | 2011 | 21941110 |
| Evolving evidence implicates cytomegalovirus as a promoter of malignant glioma pathogenesis. | ABSTRACT: Human cytomegalovirus (HCMV) was first reported to be strongly associated with human malignant gliomas in 2002. HCMV is a herpesvirus that causes congenital brain infection and multi-organ disease in immumocompromised individuals. Malignant gliomas are the most common and aggressive adult brain tumors and glioblastoma multiforme (GBM), the highest grade glioma, is associated with a life expectancy of less than two years. HCMV gene products encode for multiple proteins that can promote ... | 2011 | 22030012 |
| Phototherapy in the treatment of cutaneous herpesvirus manifestations. | There is a considerable need for effective and safe treatment of cutaneous herpesvirus lesions. Current common approaches are limited to expensive or multidose oral pills. This systematic review of evidence-based approaches to phototherapy for the various manifestations of the herpesvirus discusses original publications of controlled clinical trials and case reports that were identified through searches in PubMed, MEDLINE, and Ovid. Interventions included photodynamic therapy (PDT), UV light, an ... | 2011 | 22017068 |
| Infectious agents associated with schizophrenia: A meta-analysis. | Schizophrenia is a highly disabling and limiting disorder for patients and the possibility that infections by some microorganisms may be associated to its development may allow prevention and recovery. In the current study we have done a meta-analysis of studies that have assessed the possible association between detection of different infectious agents and schizophrenia. We report results that support the idea that there is a statistically significant association between schizophrenia and infec ... | 2011 | 22104141 |
| quantitation of human herpesvirus-6a, -6b and -7 dnas in whole blood, mononuclear and polymorphonuclear cell fractions from healthy blood donors. | diagnosis of human herpesvirus-6a (hhv-6a), -6b (hhv-6b) or -7 (hhv-7) infections is often based on the measure of viral load in blood. | 2011 | 22133730 |
| acute primary canine herpesvirus-1 dendritic ulcerative keratitis in an adult dog. | we present a report of dendritic ulcerative keratitis in a 4-year old locally immunosuppressed dog suspected to result from acute primary canine herpesvirus-1 (chv-1) infection. the dog was presented for evaluation of mild blepharospasm and conjunctival hyperemia in the right eye (od) shortly after attending a public boarding facility. for approximately 3 months, the dog had been receiving topical prednisolone acetate 1.0% and tacrolimus 0.02% in both eyes (ou) q12h for treatment of follicular c ... | 2011 | 22051326 |
| Measurement of γHV68 Infection in Mice. | ?-Herpesviruses (?-HVs) are notable for their ability to establish latent infections of lymphoid cells(1). The narrow host range of human ?-HVs, such as EBV and KSHV, has severely hindered detailed pathogenic studies. Murine ?-herpesvirus 68 (?HV68) shares extensive genetic and biological similarities with human ?-HVs and is a natural pathogen of murid rodents(2). As such, evaluation of ?HV68 infection of mice inbred strains at different stages of viral infection provides an important model for ... | 2011 | 22127138 |
| EBV-specific immune responses in patients with multiple sclerosis responding to IFN{beta} therapy. | Background: Symptomatic primary infection with the human ?-herpesvirus Epstein-Barr virus (EBV) and elevated immune responses to EBV are associated with the development and progression of multiple sclerosis (MS). Interferon-beta (IFNß), first-line treatment for relapse-onset MS, exhibits complex immunoregulatory and antiviral activities. Objective: To determine EBV-specific immune responses in patients with MS during IFNß therapy. Methods: We evaluated cellular and hu ... | 2011 | 22020417 |
| intragenic and extragenic suppression of a mutation in herpes simplex virus 1 ul34 that affects both nuclear envelope targeting and membrane budding. | late in infection herpesviruses move dna-filled capsids from the nucleus to the cytoplasm by enveloping dna-containing capsids at the inner nuclear membrane (inm) and deenveloping them at the outer nuclear membrane. this process requires two conserved herpesvirus proteins, pul31 and pul34. interaction between pul34 and pul31 is essential for targeting both proteins to the nuclear envelope (ne), and sequences that mediate the targeting interaction have been mapped in both proteins. here, we show ... | 2011 | 21900173 |
| Expression and characterization of UL16 gene from duck enteritis virus. | Previous studies have indicated that the UL16 protein and its homologs from herpesvirus were conserved and played similar roles in viral DNA packaging, virion assembly, budding, and egress. However, there was no report on the UL16 gene product of duck enteritis virus (DEV). In this study, we analyzed the amino acid sequence of UL16 using bioinformatics tools and expressed in Escherichia coli Rosetta (DE3) induced by isopropy1-ß-D-thiogalactopyranoside (IPTG). The recombinant protein was produced ... | 2011 | 21861926 |
| Cytokine Homologs of Human Gammaherpesviruses. | Gammaherpesviruses such as Epstein-Barr virus (EBV, human herpesvirus 4) and Kaposi sarcoma-associated herpesvirus (KSHV, human herpesvirus 8) establish lifelong infection in the host. To further this lifestyle, they encode homologs of cellular cytokines and cytokine receptors with the overarching goal to escape from or to blunt host antiviral defenses. EBV encodes mimics of human interleukin (hIL)-10 and a G protein-coupled receptor protein with sequence similarity to CXCR, whereas KSHV encodes ... | 2011 | 22142220 |
| Novel mouse xenograft models reveal a critical role of CD4+ T cells in the proliferation of EBV-infected T and NK cells. | Epstein-Barr virus (EBV), a ubiquitous B-lymphotropic herpesvirus, ectopically infects T or NK cells to cause severe diseases of unknown pathogenesis, including chronic active EBV infection (CAEBV) and EBV-associated hemophagocytic lymphohistiocytosis (EBV-HLH). We developed xenograft models of CAEBV and EBV-HLH by transplanting patients' PBMC to immunodeficient mice of the NOD/Shi-scid/IL-2R?(null) strain. In these models, EBV-infected T, NK, or B cells proliferated systemically and reproduced ... | 2011 | 22028658 |
| Coordinated destruction of cellular messages in translation complexes by the gammaherpesvirus host shutoff factor and the mammalian exonuclease Xrn1. | Several viruses encode factors that promote host mRNA degradation to silence gene expression. It is unclear, however, whether cellular mRNA turnover pathways are engaged to assist in this process. In Kaposi's sarcoma-associated herpesvirus this phenotype is enacted by the host shutoff factor SOX. Here we show that SOX-induced mRNA turnover is a two-step process, in which mRNAs are first cleaved internally by SOX itself then degraded by the cellular exonuclease Xrn1. SOX therefore bypasses the re ... | 2011 | 22046136 |
| comparison of humoral immune responses to epstein-barr virus and kaposi's sarcoma-associated herpesvirus using a viral proteome microarray. | epstein-barr virus (ebv) is a ubiquitous herpesvirus, and kaposi's sarcoma-associated herpesvirus (kshv) has a restricted seroprevalence. both viruses are associated with malignancies that have an increased frequency in individuals who are coinfected with human immunodeficiency virus type 1 (hiv-1). | 2011 | 21990424 |
| Actin' up: herpesvirus interactions with Rho GTPase signaling. | Herpesviruses constitute a very large and diverse family of DNA viruses, which can generally be subdivided in alpha-, beta- and gammaherpesvirus subfamilies. Increasing evidence indicates that many herpesviruses interact with cytoskeleton-regulating Rho GTPase signaling pathways during different phases of their replication cycle. Because of the large differences between herpesvirus subfamilies, the molecular mechanisms and specific consequences of individual herpesvirus interactions with Rho GTP ... | 2011 | 21994732 |
| production of recombinant herpesvirus saimiri-based vectors. | herpesvirus saimiri (hvs) is capable of infecting a range of human cell types with high efficiency. the viral genome persists as high-copy-number, circular, nonintegrated episomes that segregate to progeny upon cell division. this allows hvs-based vectors to transduce stably a dividing cell population and provide sustained transgene expression for an extended period of time both in vitro and in vivo. moreover, the insertion of a bacterial artificial chromosome (bac) cassette into the hvs genome ... | 2011 | 22135662 |
| ccaat/enhancer binding proteins play a role in orilyt-dependent genome replication during mhv-68 de novo infection. | murine gammaherpesvirus 68 (mhv-68), a member of the gammaherpesvirus family, replicates robustly in permissive cell lines and is able to infect laboratory mice. mhv-68 has emerged as a model for studying the basic aspects of viral replication and host-virus interactions of its human counterparts. herpesvirus genome replication is mediated through a cis-element in the viral genome called the origin of lytic replication (orilyt). a family of transcription factors, ccaat/enhancer binding proteins ... | 2011 | 21748596 |
| Canine parvovirus-2b-associated erythema multiforme in a litter of English Setter dogs. | Erythema multiforme (EM) was diagnosed in a litter of English Setter puppies. The puppies developed erythematous cutaneous lesions at the age of 2 weeks. Microscopically, there was individual keratinocyte apoptosis associated with lymphocyte exocytosis in all layers of the epidermis. Intranuclear viral inclusions were seen in multiple tissues and organs. Tissues from the tongue, lymph node, spleen, skin, and small intestine were positive for Canine parvovirus-2 (CPV-2) and negative for Canine di ... | 2011 | 21908294 |
| Recombinant herpesvirus of turkeys as a vector-based vaccine against highly pathogenic H7N1 avian influenza and Marek's disease. | A major challenge for poultry vaccination is the design of vaccines that protect against multiple pathogens via a single protective dose delivered through mass vaccination methods. In this investigation, we examined herpesvirus of turkeys (HVT) as a vaccine vector for delivery of haemagglutinin (HA) antigen of highly pathogenic H7N1 avian influenza virus that can act as a dual vaccine against avian influenza and Marek's disease. The HVT vector was developed using reverse genetics based on an inf ... | 2011 | 21907750 |
| Small RNA deep-sequencing identifies microRNAs and other small non-coding RNAs from human herpesvirus 6 (HHV-6B). | Roseolovirus, or human herpesvirus 6 (HHV-6) is a ubiquitous human pathogen infecting over 95% of the population by the age of two years. As with other herpesviruses, reactivation of HHV-6 can present with severe complications in immunocompromised individuals. Recent studies have highlighted the importance of herpesvirus-derived micro (mi)RNAs in modulating both cellular and viral gene expression. An initial report, which computed the likelihood of various viruses to encode for miRNAs, did not p ... | 2011 | 22114334 |
| lethal human herpesvirus-6 encephalitis after cord blood transplant. | f. forest, s. duband, s. pillet, m.-l. stachowicz, j. cornillon, j.-m. dumollard, m. peoc'h. lethal human herpesvirus-6 encephalitis after cord blood transplant. transpl infect dis 2011: 13: 646-649. all rights reserved abstract: clinical, biological, pathological, and imaging findings were all suggestive of lethal human herpesvirus-6-associated encephalitis in a 61-year-old man who had undergone a cord blood transplant. the neuropathological findings of this unusual autopsy case and the pathoge ... | 2011 | 21883755 |
| antibody evasion by a gammaherpesvirus o-glycan shield. | all gammaherpesviruses encode a major glycoprotein homologous to the epstein-barr virus gp350. these glycoproteins are often involved in cell binding, and some provide neutralization targets. however, the capacity of gammaherpesviruses for long-term transmission from immune hosts implies that in vivo neutralization is incomplete. in this study, we used bovine herpesvirus 4 (bohv-4) to determine how its gp350 homolog--gp180--contributes to virus replication and neutralization. a lack of gp180 had ... | 2011 | 22114560 |
| Avian polyomavirus infection of a fledgling budgerigar (Melopsittacus undulatus) and differential diagnoses of viral inclusions in psittacine birds--case report and mini-review. | A two-week-old budgerigar (Melopsittacus undulatus) of an outdoor aviary died suddenly and was submitted for determination the cause of illness and death. Macroscopically, the sparsely feathered animal was in a poor body condition. Histopathological examination revealed in various mesenchymal and epithelial tissues, numerous up to 15 microm in diameter large intranuclear, amphophilic to basophilic inclusion bodies with a clearing of the centre. Additionally, a feather dysplasia and retention hyp ... | 2011 | 22059291 |
| Development of a set of multiplex standard polymerase chain reaction assays for the identification of infectious agents from aborted bovine clinical samples. | The current study describes the development of a set of 5 multiplex polymerase chain reaction (mPCR) assays for the simultaneous detection of abortive infection agents in bovine fetal tissues, including Brucella spp., Leptospira spp., and Campylobacter fetus (mPCR1); Hammondia heydorni, Neospora caninum, and Toxoplasma gondii (mPCR2); Coxiella burnetii and Chlamydophila psittaci (mPCR3); Mycoplasma bovis, Mycoplasma bovigenitalium, and Ureaplasma diversum (mPCR4); and Bovine viral diarrhea virus ... | 2011 | 21908306 |
| hiv-negative disseminated kaposi's sarcoma in a taiwanese patient. | kaposi's sarcoma is a common malignancy associated with hiv/aids. herein, we describe the case of a 26-year-old man who presented with bilateral neck and inguinal lymphadenopathy, a massive tumor on the gum, and a nodule over the left eye. a series of tests, including tumor biopsies, were performed, and disseminated kaposi's sarcoma with human herpesvirus 8 infection was diagnosed. to test for hiv, we used enzyme-linked immunosorbent assay and real-time polymerase chain reaction, but the results ... | 2011 | 22208543 |
| pathology of kaposi's sarcoma-associated herpesvirus infection. | kaposi's sarcoma-associated herpesvirus (kshv; human herpesvirus 8) is a human herpesvirus, classified as a gamma-herpesvirus. kshv is detected in kaposi's sarcoma (ks), primary effusion lymphoma (pel), and some cases of multicentric castleman's disease (mcd). similar to other herpes viruses, there are two phases of infection, latent and lytic. in kshv-associated malignancies such as ks and pel, kshv latently infects almost all tumor cells. quantitative pcr analysis revealed that each tumor cell ... | 2011 | 21904536 |
| clinical characteristics of patients with epstein barr virus in cerebrospinal fluid. | the role of epstein-barr (ebv) virus in central nervous system (cns) infections is not fully resolved. it is clearly associated with lymphoproliferative disease of immunosuppressed persons, and may cause encephalitis. | 2011 | 22018204 |
| The periodontal pathogen Porphyromonas gingivalis induces the Epstein-Barr virus lytic switch transactivator ZEBRA by histone modification. | Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus that usually results in latent infection of B cells. The EBV BZLF1 gene product ZEBRA is a master regulator of the transition from latency to the lytic replication cycle. In the latent state, hypoacetylation of histone proteins in the BZLF1 promoter by histone deacetylases (HDACs) is primarily involved in maintaining EBV latency. Although the mechanism that regulates the switch between latency and lytic replication has been a central res ... | 2011 | 22178321 |
| multiple defects, including premature apoptosis, prevent kaposi's sarcoma-associated herpesvirus replication in murine cells. | the development of a mouse model for kaposi's sarcoma-associated herpesvirus (kshv) infection has been impeded by the limited host range of the virus. here, we have examined the molecular basis of this host range restriction. kshv efficiently enters murine cells and establishes latency. however, ectopic expression of the lytic switch protein rta (replication and transcription activator) in these cells induces little viral gene expression and no virus production. upon treatment with histone deace ... | 2011 | 22130538 |
| a possible case of caprine-associated malignant catarrhal fever in a domestic water buffalo (bubalus bubalis) in switzerland. | abstract: | 2011 | 22132808 |
| Delineation of a core RNA element required for Kaposi's sarcoma-associated herpesvirus ORF57 binding and activity. | The Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 protein is an essential multifunctional regulator of gene expression. ORF57 interaction with RNA is necessary for ORF57-mediated posttranscriptional functions, but little is known about the RNA elements that drive ORF57-RNA specificity. Here, we investigate the cis-acting factors on the KSHV PAN RNA that dictate ORF57 binding and activity. We show that ORF57 binds directly to the 5' end of PAN RNA in KSHV-infected cells. Furthermore, we em ... | 2011 | 21889182 |
| infection of peripheral blood mononuclear cells with neuropathogenic equine herpesvirus type-1 strain ab4 reveals intact interferon-a induction and induces suppression of anti-inflammatory interleukin-10 responses in comparison to other viral strains. | the recent increase in incidence, morbidity, and mortality of neurological disease induced by equine herpesvirus type 1 (ehv-1) has suggested a change of virulence of the virus. the exact mechanisms by which ehv-1 induces neurologic disease are not known. environmental, viral, and host risk factors might contribute to neurological manifestation. here, we investigated innate interferon-a (ifn-a), interleukin-10 (il-10) and il-4 responses after infection of equine peripheral blood mononuclear cell ... | 2011 | 21764140 |
| Restricted Kaposi's sarcoma (KS) herpesvirus transcription in KS lesions from patients on successful antiretroviral therapy. | Kaposi's sarcoma (KS) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV; human herpesvirus 8). KS is an AIDS-defining cancer, and it is changing in the post-antiretroviral therapy (post-ART) era. In countries with ready access to ART, approximately one-third of KS cases present in patients with undetectable HIV loads and CD4 counts of =200 cells/µl. This is in contrast to pre-ART era KS, which was associated with systemic HIV replication and CD4 counts of =200 cells/µl. Using primary pa ... | 2011 | 22045987 |
| Herpesvirus telomerase RNA (vTR) with a mutated template sequence abrogates herpesvirus-induced lymphomagenesis. | Telomerase reverse transcriptase (TERT) and telomerase RNA (TR) represent the enzymatically active components of telomerase. In the complex, TR provides the template for the addition of telomeric repeats to telomeres, a protective structure at the end of linear chromosomes. Human TR with a mutation in the template region has been previously shown to inhibit proliferation of cancer cells in vitro. In this report, we examined the effects of a mutation in the template of a virus encoded TR (vTR) on ... | 2011 | 22046133 |
| structure-function analysis of varicella-zoster virus glycoprotein h identifies domain-specific roles for fusion and skin tropism. | enveloped viruses require membrane fusion for cell entry and replication. for herpesviruses, this event is governed by the multiprotein core complex of conserved glycoproteins (g)b and gh/gl. the recent crystal structures of gh/gl from herpes simplex virus 2, pseudorabies virus, and epstein-barr virus revealed distinct domains that, surprisingly, do not resemble known viral fusogens. varicella-zoster virus (vzv) causes chicken pox and shingles. vzv is an α-herpesvirus closely related to herpes s ... | 2011 | 22025718 |
| Antigen-specific IFN-gamma and IL-4 production in caprine herpesvirus infected goats. | The analysis of cytokines secreted by antigen-specific lymphocytes is hampered in goats by the paucity of species-specific reagents yet it is crucial to study immune responses to infections. To overcome this limit, two commercial kits designed to measure soluble bovine IL-4 (by ELISA) and frequencies of bovine IFN-gamma secreting cells (by ELISPOT) were tested for cross-reactivity in goats. In addition, an ELISA specific to bovine/ovine IL-4 and employing two monoclonal antibodies, clones CC313 ... | 2011 | 22063880 |
| latent kshv infection increases the vascular permeability of human endothelial cells. | kaposi sarcoma-associated herpesvirus (kshv) is associated with 3 different human malignancies: kaposi sarcoma (ks), primary effusion lymphoma, and multicentric castleman disease. the ks lesion is driven by kshv-infected endothelial cells and is highly dependent on autocrine and paracrine factors for survival and growth. we report that latent kshv infection increases the vascular permeability of endothelial cells. endothelial cells with latent kshv infection display increased rac1 activation and ... | 2011 | 21881052 |
| Detection of herpes simplex virus type-1 in patients with fibrotic lung diseases. | The current study intends to investigate i) the incidence of herpes viruses including Herpes Simplex Virus type-1 (HSV-1), Cytomegalovirus (CMV) and Human Herpes Virus -6, -7, -8 (HHV6, HHV7, HHV8) in two biological samples, bronchoalveolar lavage fluid (BALF) and lung tissue biopsy, in different forms of pulmonary fibrosis, and ii) the induction of molecular pathways involved in fibrosis by herpesvirus infection in primary cell cultures. PCR was employed for the detection of CMV, HHV6-8 and HSV ... | 2011 | 22205929 |
| A duck enteritis virus-vectored bivalent live vaccine provides fast and complete protection against H5N1 avian influenza virus infection in ducks. | Ducks play an important role in the maintenance of highly pathogenic H5N1 avian influenza viruses (AIVs) in nature, and the successful control of AIVs in ducks has important implications for the eradication of the disease in poultry and its prevention in humans. The inactivated influenza vaccine is expensive, labor-intensive, and usually needs 2 to 3 weeks to induce protective immunity in ducks. Live attenuated duck enteritis virus (DEV; a herpesvirus) vaccine is used routinely to control lethal ... | 2011 | 21865383 |
| adoptive immunotherapy with virus-specific t cells. | viral infections are still common causes of morbidity and mortality in immunosuppressed patients after allogeneic hematopoietic stem cell transplantation. infections caused by virus such as cytomegalovirus, adenovirus and epstein-barr virus are well-known. in addition, several other viruses such as polyomavirus and human herpesvirus 6 have been recently reported to be causes of significant complications. as the delay in recovery of virus-specific cellular immune response after transplant is asso ... | 2011 | 21925094 |
| proteasome inhibitors induce apoptosis and reduce viral replication in primary effusion lymphoma cells. | primary effusion lymphoma (pel) is an aggressive neoplasm caused by kaposi's sarcoma-associated herpesvirus (kshv). this study provides evidence that proteasomal activity is required for both survival of pel cells stably harboring the kshv genome and viral replication of kshv. we evaluated the cytotoxic effects of proteasome inhibitors on pel cells. the proteasome inhibitors mg132, lactacystin, and proteasome inhibitor i dramatically inhibited cell proliferation and induced apoptosis of pel cell ... | 2011 | 22074820 |
| Identification of a novel herpesvirus associated with cutaneous ulcers in a fisher (Martes pennanti). | On December 8, 2008, a male fisher (Martes pennanti) housed in a quarantine enclosure at the St-Félicien Zoo was found dead with multiple skin ulcers on the muzzle and plantar pads. At necropsy, no major findings were found, and a specific cause of death was not determined microscopically. However, at the borders of ulcerated sites, there were increased numbers of koilocytes, with perinuclear vacuolation and nuclear enlargement. A pan-herpesvirus nested polymerase chain reaction (PCR) assay was ... | 2011 | 21908360 |
| Involvement of viral factors with head and neck cancers. | The incidence of head and neck cancer remains high and is associated with many deaths in both Western and Asian countries. Common risk factors in head and neck carcinoma are smoking and alcohol abuse, however, in an increasing proportion of cases, no significant smoking or drinking history has been reported. The infectious nature of oncogenic viruses sets them apart from other carcinogenic agents. As such, a thorough study of both the pathogenesis of viral infection and the host response is cruc ... | 2011 | 22078009 |
| field efficacy of different vaccines against infectious bursal disease in broiler flocks. | a field study was performed to determine the efficacy of three commercially available vaccines against infectious bursal disease (ibd) in commercial broilers raised in a high ibd virus (ibdv) risk area. live attenuated intermediate and intermediate plus vaccines were used in four flocks. birds were vaccinated orally at the estimated vaccination time. three broiler flocks were vaccinated subcutaneously with a turkey herpesvirus (hvt)-ibd vector vaccine at one day old. evaluation of the efficacy o ... | 2011 | 21727070 |
| molecular basis for herpesvirus entry mediator recognition by the human immune inhibitory receptor cd160 and its relationship to the cosignaling molecules btla and light. | cd160 was recently identified as a t cell coinhibitory molecule that interacts with the herpesvirus entry mediator (hvem) on antigen-presenting cells to deliver a potent inhibitory signal to cd4(+) t cells. hvem also binds to the coinhibitory receptor btla (b- and t-lymphocyte attenuator) and the costimulatory receptor light (which is homologous to lymphotoxins, exhibits inducible expression, and competes with the herpes simplex virus glycoprotein d for hvem, a receptor expressed by t lymphocyte ... | 2011 | 21959263 |
| skin mucus of cyprinus carpio inhibits cyprinid herpesvirus 3 binding to epidermal cells. | abstract: cyprinid herpesvirus 3 (cyhv-3) is the aetiological agent of a mortal and highly contagious disease in common and koi carp. the skin is the major portal of entry of cyhv-3 in carp after immersion in water containing the virus. in the present study, we used in vivo bioluminescence imaging to investigate the effect of skin mucus removal and skin epidermis lesion on cyhv-3 entry. physical treatments inducing removal of the mucus up to complete erosion of the epidermis were applied on a de ... | 2011 | 21816061 |
| Viral Interferon Regulatory Factors decrease the induction of Type I and Type II IFN during Rhesus Macaque Rhadinovirus Infection. | Kaposi's sarcoma-associated herpesvirus and rhesus macaque rhadinovirus (RRV), two closely related ?-herpesviruses, are unique in their expression of viral homologs of cellular interferon regulatory factors (IRFs), termed viral IRFs (vIRFs). To assess the role of the vIRFs during de novo infection, we have utilized the bacterial artificial chromosome clone of RRV(17577) (WT(BAC) RRV) to generate a recombinant virus with all 8 of the vIRFs deleted (vIRF-ko RRV). Infection of primary rhesus fibrob ... | 2011 | 22156526 |
| Human herpesvirus 6 in biopsies from patients with gastrointestinal symptoms after allogeneic stem cell transplantation. | Gastrointestinal complications are frequent after allogeneic stem cell transplantation (allo-SCT). Main differential diagnoses are graft-versus-host disease (GvHD) and viral infections. In this retrospective analysis, we included 50 patients with severe vomiting or diarrhea in the first year after allo-SCT. One hundred two biopsies obtained by colonoscopy or endoscopy of the upper gastrointestinal tract were analysed by conventional histology for signs of GvHD and by qualitative polymerase chain ... | 2011 | 22048789 |
| deciphering the role of epstein-barr virus in the pathogenesis of t and nk cell lymphoproliferations. | abstract: epstein-barr virus (ebv) is a highly successful herpesvirus, colonizing more than 90% of the adult human population worldwide, although it is also associated with various malignant diseases. primary infection is usually clinically silent, and subsequent establishment of latency in the memory b lymphocyte compartment allows persistence of the virus in the infected host for life. ebv is so markedly b-lymphotropic when exposed to human lymphocytes in vitro that the association of ebv with ... | 2011 | 21899744 |
| sequencing of bovine herpesvirus 4 v.test strain reveals important genome features. | bovine herpesvirus 4 (bohv-4) is a useful model for the human pathogenic gammaherpesviruses epstein-barr virus and kaposi's sarcoma-associated herpesvirus. although genome manipulations of this virus have been greatly facilitated by the cloning of the bohv-4 v.test strain as a bacterial artificial chromosome (bac), the lack of a complete genome sequence for this strain limits its experimental use. | 2011 | 21846388 |
| outbreak of human herpesvirus type 1 infection in nonhuman primates (callithrix penincillata). | human herpesvirus type 1 (hhv-1) is widely dispersed among the human population. although infection is often asymptomatic in humans, nonhuman primates develop a severe and often fatal infection. in august 2006, 13 black-tufted marmosets (callithrix penincillata) from a group of 14 presented with clinical apathy, anorexia, and ataxia. physical examination revealed conjunctivitis, erosive or ulcerative lesions on the skin, and swollen lymph nodes. of the 14 animals captured, 10 died. grossly, ulce ... | 2011 | 21719834 |
| ß-HHVs and HHV-8 in Lymphoproliferative Disorders. | Similarly to Epstein-Barr virus (EBV), the human herpesvirus-8 (HHV-8) is a ?-herpesvirus, recently recognized to be associated with the occurrence of rare B cell lymphomas and atypical lymphoproliferations, especially in the human immunodeficiency virus (HIV) infected subjects. Moreover, the human herpesvirus-6 (HHV-6), a ß-herpesvirus, has been shown to be implicated in some non-malignant lymph node proliferations, such as the Rosai Dorfman disease, and in a proportion of Hodgkin's lymphoma ca ... | 2011 | 22110893 |
| Kaposi's Sarcoma Herpesvirus microRNAs Target Caspase 3 and Regulate Apoptosis. | Kaposi's sarcoma herpesvirus (KSHV) encodes a cluster of twelve micro (mi)RNAs, which are abundantly expressed during both latent and lytic infection. Previous studies reported that KSHV is able to inhibit apoptosis during latent infection; we thus tested the involvement of viral miRNAs in this process. We found that both HEK293 epithelial cells and DG75 cells stably expressing KSHV miRNAs were protected from apoptosis. Potential cellular targets that were significantly down-regulated upon KSHV ... | 2011 | 22174674 |
| induction of cd56(+) t cells after prolonged activation of t cells in vitro: a possible mechanism for cd4(+) t-cell depletion in acquired immune deficiency syndrome patients. | the pathogenic mechanisms responsible for depletion of cd4(+) t cells in aquired immune deficiency syndrome (aids) are not fully understood. systemic immune activation mediated by persistent infection of human immunodeficiency virus (hiv) seems to be one of the predictors of disease progression. we predicted that certain lymphocytes responsible for cd4(+) t-cell depletion could be induced in patients during prolonged activation of lymphocytes. therefore, we have established an in vitro long-term ... | 2011 | 21741423 |
| resveratrol inhibits proliferation and survival of epstein barr virus-infected burkitt's lymphoma cells depending on viral latency program. | resveratrol (3,4',5-trihydroxy-trans-stilbene), a polyphenolic natural product, shows chemopreventive properties against several cancers, heart diseases, inflammation, and viral infections. epstein barr virus (ebv), a γ-herpesvirus, contributes to the development of several human cancers including burkitt's lymphoma (bl). in this study, we asked whether treatment with resveratrol would affect the viability of ebv-positive bl cells displaying different forms of latency. we report here that resver ... | 2011 | 21856773 |
| direct and specific binding of the ul16 tegument protein of herpes simplex virus to the cytoplasmic tail of glycoprotein e. | the ul16 tegument protein of herpes simplex virus (hsv) is conserved throughout all of the herpesvirus families. previous studies have shown that the binding of hsv to heparan sulfate molecules on the host cell triggers the release of ul16 from the capsid, but the mechanism by which the signal is sent from the virion surface into the tegument is unknown. here, we report that a glutathione s-transferase chimera bearing the cytoplasmic tail of viral glycoprotein e (ge) is capable of binding to ul1 ... | 2011 | 21734044 |
| Rapamycin with Antiretroviral Therapy in AIDS-Associated Kaposi Sarcoma: An AIDS Malignancy Consortium Study. | PURPOSE: The mammalian target of rapamycin (mTOR) is activated in Kaposi sarcoma (KS) and its inhibitor, rapamycin, has induced KS regression in transplant-associated KS. This study aimed to evaluate rapamycin's safety and toxicity in HIV-infected individuals with KS receiving antiretroviral therapy (ART), investigate rapamycin interactions with both protease inhibitor (PI)-containing and non-nucleoside reverse transcriptase inhibitor (NNRTI)-containing ART regimens, and assess clinical and biol ... | 2011 | 22067664 |
| the intrinsic antiviral defense to incoming hsv-1 genomes includes specific dna repair proteins and is counteracted by the viral protein icp0. | cellular restriction factors responding to herpesvirus infection include the nd10 components pml, sp100 and hdaxx. during the initial stages of hsv-1 infection, novel sub-nuclear structures containing these nd10 proteins form in association with incoming viral genomes. we report that several cellular dna damage response proteins also relocate to sites associated with incoming viral genomes where they contribute to the cellular front line defense. we show that recruitment of dna repair proteins t ... | 2011 | 21698222 |
| Murine gamma herpesvirus 68 hijacks MAVS and IKKß to abrogate NF?B activation and antiviral cytokine production. | Upon viral infection, mitochondrial antiviral signaling (MAVS) protein serves as a key adaptor to promote cytokine production. We report here that murine gamma herpesvirus 68 (?HV68), a model virus for oncogenic human gamma herpesviruses, subverts cytokine production via the MAVS adaptor. During early infection, ?HV68 hijacks MAVS and IKKß to induce the site-specific phosphorylation of RelA, a crucial subunit of the transcriptionally active NF?B dimer, which primes RelA for the proteasome-mediat ... | 2011 | 22110409 |
| human herpesvirus 6 and 7 reactivation and disease activity in multiple sclerosis. | recent studies have focused on the associations between human herpesvirus 6 (hhv-6) and human herpesvirus 7 (hhv-7), and multiple sclerosis (ms). the aim of this study was to investigate the associations between hhv-6 and hhv-7 reactivation and ms disease activity, and interleukin 12 (il-12) and tumor necrosis factor α (tnf-α) production. material and methods. the frequency of plasma viremia by nested polymerase chain reaction and transcription of viral mrna in peripheral blood mononuclear cells ... | 2011 | 22186115 |
| activation of pi3k/akt and erk mapk signal pathways is required for the induction of lytic cycle replication of kaposi's sarcoma-associated herpesvirus by herpes simplex virus type 1. | kaposi's sarcoma-associated herpesvirus (kshv) is causally linked to several acquired immunodeficiency syndrome-related malignancies, including kaposi's sarcoma (ks), primary effusion lymphoma (pel) and a subset of multicentric castleman's disease. regulation of viral lytic replication is critical to the initiation and progression of ks. recently, we reported that herpes simplex virus type 1 (hsv-1) was an important cofactor that activated lytic cycle replication of kshv. here, we further invest ... | 2011 | 22032493 |
| recent publications in medical microbiology and immunology: a retrospective. | a look back is done to some clinical and basic research activities recently published in medical microbiology and immunology. the review covers clinical experiences and in vitro experiments to understand the emergency, pathogenicity, epidemic spread, and vaccine-based prevention of avian and swine-origin flu. some new developments and concepts in diagnosis, (molecular) epidemiology, and therapy of aids, viral hepatitis c, and herpesvirus-associated diseases are outlined. regulation of immune sys ... | 2011 | 22033658 |
| kshv regulation of fibulin-2 in kaposi's sarcoma implications for tumorigenesis. | kaposi's sarcoma is an angioproliferative tumor caused by kaposi's sarcoma-associated herpesvirus (kshv) infection of vascular endothelial cells. fibulins, proteins that associate with extracellular matrix (ecm) proteins, may have both tumor-suppressive and oncogenic activities. we found that the expression of fibulin-2 protein and mrna were decreased 50-fold and 26-fold, respectively, in 10-day kshv-infected dermal microvascular endothelial cells (dmvec). using quantitative rt-pcr, we found a f ... | 2011 | 21741351 |
| mammalian alphaherpesvirus mirnas. | mammalian alphaherpesviruses are major causes of human and veterinary disease. during productive infection, these viruses exhibit complex and robust patterns of gene expression. these viruses also form latent infections in neurons of sensory ganglia in which productive cycle gene expression is highly repressed. both modes of infection provide advantageous opportunities for regulation by micrornas. thus far, published data regarding micrornas are available for six mammalian alphaherpesviruses. no ... | 2011 | 21736960 |
| inbreeding depression increases susceptibility to bovine tuberculosis in lions: an experimental test using an inbred-outbred contrast through translocation. | disease can dramatically influence the dynamics of endangered wildlife populations, especially when they are small and isolated, with increased risk of inbreeding. in hluhluwe-imfolozi park (hip), a small, enclosed reserve in south africa, a large lion (panthera leo) population arose from a small founder group in the 1960s and started showing conspicuous signs of inbreeding. to restore the health status of the hip lion population, outbred lions were translocated into the existing population. in ... | 2011 | 21719814 |
| The Cytomegaloviral Protein pUL138 Acts as Potentiator of Tumor Necrosis Factor (TNF) Receptor 1 Surface Density To Enhance ULb'-Encoded Modulation of TNF-a Signaling. | Human cytomegalovirus is a ubiquitous herpesvirus that establishes lifelong latent infection. Changes in immune homeostasis induce the reactivation of lytic infection, which is mostly inapparent in healthy individuals but often causes overt disease in immunocompromised hosts. Based on discrepant tumor necrosis factor receptor 1 surface disposition between human cytomegalovirus AD169 variants differing in the ULb' region, we identified the latency-associated gene product pUL138, which also is exp ... | 2011 | 21976655 |
| An antisense transcript in the human cytomegalovirus UL87 gene region. | ABSTRACT: | 2011 | 22074130 |
| Inhibition of the inflammasome response by a viral protein that interacts with NLRs. | Pattern recognition receptors (PRRs) constitute the first line of host defense against bacterial, fungal and viral pathogens. Upon sensing microbial infection, PRRs initiate a cascade of signal transduction and transcriptional events to induce the production of inflammatory cytokines. As a result, many pathogens have evolved to evade PRR detection and activation in order to establish a successful infection. In a recent report, we described how a viral protein named Orf63 encoded by Kaposi's sarc ... | 2011 | 21966559 |
| case reports of neuro-chikungunya in southern thailand. | abstract. there has been a recent increase in reports of neurologic complications as major causes of morbidity and mortality in chikungunya virus infection. as a part of 2004-2009 global outbreaks, an unprecedented large chikungunya epidemic occurred in southern thailand during 2008-2009 in which 49,069 cases were reported. during this period, we encountered two patients with meningoencephalitis and another patient with myeloneuropathy among 1,018 cases diagnosed as chikungunya in our hospital. ... | 2011 | 21813863 |
| rare, unusual, and less common virus infections after organ transplantation. | the present article reviews the epidemiology, clinical presentation, prevention, and management of rare, unusual, and less common viruses that infect transplant recipients. | 2011 | 22001713 |
| a leucine zipper motif of a tegument protein triggers final envelopment of human cytomegalovirus. | the gene product of human cytomegalovirus (hcmv) ul71 is conserved throughout the herpesvirus family. during hcmv infection, pul71 is required for efficient virion egress and involved in the final steps of secondary envelopment leading to infectious viral particles. we found strong indications for an oligomerization of pul71 under native conditions when recombinant pul71 was negatively stained and analyzed by electron microscopy. oligomerization of pul71 during infection was further verified by ... | 2011 | 22205740 |
| human herpesvirus 8 viral interleukin-6 interacts with splice variant 2 of vitamin k epoxide reductase complex subunit 1. | viral interleukin-6 (vil-6) specified by human herpesvirus 8 is, unlike its cellular counterpart, secreted very inefficiently and can signal via vil-6(2):gp130(2) signaling complexes from the endoplasmic reticulum (er) compartment. intracellular, autocrine activities of vil-6 are important for proproliferative and prosurvival activities of the viral cytokine in latently infected primary effusion lymphoma (pel) cells. however, the molecular determinants of vil-6 er localization and function are u ... | 2011 | 22130532 |
| kinetics and pathogenicity of oral infection by equine herpesvirus-9 in mice and suckling hamsters. | the pathogenesis and kinetics of oral infection by equine herpesvirus (ehv)-9 were studied in mice and hamsters. after oral inoculation of 10(5) plaque-forming units (pfu) of virus, 1-week-old suckling hamsters showed varying severity of neurological disease from 72hours post inoculation (hpi) and all of these animals had died by 96-áhpi. four-week-old icr mice inoculated orally with 4+ù10(4)pfu of virus showed no clinical signs, but they developed erosive and ulcerative gastritis from 36-áhpi. ... | 2011 | 21741053 |
| nuclear envelope breakdown can substitute for primary envelopment-mediated nuclear egress of herpesviruses. | herpesvirus nucleocapsids assemble in the nucleus but mature to infectious virions in the cytoplasm. to gain access to this cellular compartment, nucleocapsids are translocated to the cytoplasm by primary envelopment at the inner nuclear membrane and subsequent fusion of the primary envelope with the outer nuclear membrane. the conserved viral pul34 and pul31 proteins play a crucial role in this process. in their absence, viral replication is strongly impaired but not totally abolished. we used ... | 2011 | 21680518 |
| a-ásilence element involved in kaposi+äs-ásarcoma-associated herpesvirus orf11 gene expression. | 2011 | 21692569 | |
| prevalence of respiratory pathogens in diseased, non-vaccinated, routinely medicated veal calves. | the prevalence of respiratory pathogens in diseased veal calves was determined in 24 respiratory disease outbreaks in 15 herds in belgium. bacteria were cultured from nasopharyngeal swabs and seroconversion against viruses and mycoplasma bovis was determined on paired sera. at the individual calf level, mycoplasma species, mannheimia haemolytica and pasteurella multocida, were isolated from 70.5 per cent, 21.5 per cent and 26.0 per cent of swabs, respectively. at the herd level, the presence of ... | 2011 | 21831999 |
| molecular data of ul24 homolog gene (orf37) from brazilian isolates of equine herpesvirus type 1. | equine herpesvirus type 1 (ehv-1) is associated with abortions, respiratory distress, and neurological disturbances in horses. the orf37 of ehv-1 encodes a protein homolog to ul24 gene product of human herpesvirus that has been associated with neurovirulence. in the present work, orf37 pcr fragments derived from two brazilian ehv-1 isolates, a german isolate and an american reference strain were sequenced and characterized by molecular phylogenetic analysis. this genomic region is highly conserv ... | 2011 | 21684566 |
| surveillance programme for important equine infectious respiratory pathogens in the usa. | the prevalence and epidemiology of important viral (equine influenza virus [eiv], equine herpesvirus type 1 [ehv-1] and ehv-4) and bacterial (streptococcus equi subspecies equi) respiratory pathogens shed by horses presented to equine veterinarians with upper respiratory tract signs and/or acute febrile neurological disease were studied. veterinarians from throughout the usa were enrolled in a surveillance programme and were asked to collect blood and nasal secretions from equine cases with acut ... | 2011 | 21676986 |
| aspects of bovine herpesvirus-1 infection in dairy and beef herds in the republic of ireland. | infection with bovine herpesvirus-1 (bhv-1) causes a wide range of disease manifestations, including respiratory disease and abortion, with world-wide distribution. the primary objective of the present study was to describe aspects of bhv-1 infection and control on irish farms, including herd-level seroprevalence (based on pooled sera) and vaccine usage. | 2011 | 21699677 |
| secondary lymphoid tissue as an important site for wu polyomavirus infection in immunocompetent children. | the polyomaviruses ki and wu (kipyv and wupyv) have been identified in respiratory specimens from children with acute respiratory infections, which suggests the respiratory tract as a possible site of infection. however, the persistence of infection in the lymphoid system is unknown. fresh samples (n = 211) of tonsils, adenoids, and peripheral blood mononuclear cells (pbmcs) from 83 immunocompetent children (mean age 4.8 years) were tested for amplification of the kipyv vp1 and wupyv vp2 genes. ... | 2011 | 21678449 |
| identification of a novel marine fish virus, singapore grouper iridovirus-encoded micrornas expressed in grouper cells by solexa sequencing. | micrornas (mirnas) are ubiquitous non-coding rnas that regulate gene expression at the post-transcriptional level. an increasing number of studies has revealed that viruses can also encode mirnas, which are proposed to be involved in viral replication and persistence, cell-mediated antiviral immune response, angiogenesis, and cell cycle regulation. singapore grouper iridovirus (sgiv) is a pathogenic iridovirus that has severely affected grouper aquaculture in china and southeast asia. comprehens ... | 2011 | 21559453 |
| molecular detection of murine herpesvirus 68 in ticks feeding on free-living reptiles. | the mhv-68 (designed as murid herpesvirus 4 (muhv 4) strain 68) isolated from two rodents, myodes glareolus and apodemus flavicollis, is considered as a natural pathogen of free-living murid rodents. recently, the detection of mhv antibodies in the blood of animals living in the same biotope as mhv-infected mice has suggested that ticks may have a role in the transmission of this pathogen. ixodes ricinus is one the most abundant tick species in europe known to transmit multiple pathogens causing ... | 2011 | 21732020 |
| differentiating inherited human herpesvirus type 6 genome from primary human herpesvirus type 6 infection by means of dried blood spot from the newborn screening card. | to differentiate active human herpesvirus type 6 (hhv-6) infection from inherited hhv-6 (ihhv-6), we analyzed dried blood spots from archived newborn screening cards in 3 patients with high hhv-6 dna copy numbers. two patients were positive for hhv-6 dna as neonates suggesting ihhv-6. in 1 patient, the absence of hhv-6 dna excluded ihhv-6. | 2011 | 21840541 |
| malignant catarrhal fever in cows due to ovine herpesvirus type 2. | 2011 | 21842548 | |
| nationwide cyprinid herpesvirus 3 contamination in natural rivers of japan. | cyprinid herpesvirus 3 (cyhv-3) disease is a significant threat for common and koi carp cultivators and for freshwater ecosystems. to determine the prevalence of cyhv-3 in japanese rivers, a nationwide survey of all national class-a rivers was undertaken in the summer of 2008. the virus was concentrated from river water samples using the cation-coated filter method. cyhv-3 dna was detected in 90 rivers, representing 90% of 103 successfully analysed rivers. more than 100,000 copies of cyhv-3 dna ... | 2011 | 21723573 |
| high levels of light and low levels of soluble herpesvirus entry mediator in sera of patients with atopic dermatitis. | 2011 | 21623877 | |
| kshv virf-2 inhibits type 1 interferon signalling by targeting isgf-3. | kaposi's sarcoma-associated herpesvirus (kshv) encodes four viral interferon regulatory factors (virf-1-4). we investigated the mechanism and consequences of virf-2-mediated inhibition of interferon-response element (isre) signalling following type i interferon (ifn) induction. western blot and electrophoretic mobility shift assays identified the interferon stimulated gene factor-3 (isgf-3) components stat-1 and irf-9 as the proximal targets of virf-2 activity. the biological significance of vir ... | 2011 | 21697347 |
| cytoplasmic localized infected cell protein 0 (bicp0) encoded by bovine herpesvirus 1 inhibits +¦ interferon promoter activity and reduces irf3 (interferon response factor 3) protein levels. | bovine herpesvirus 1 (bhv-1), an alpha-herpesvirinae subfamily member, establishes a life-long latent infection in sensory neurons. periodically, bhv-1 reactivates from latency, infectious virus is spread, and consequently virus transmission occurs. bhv-1 acute infection causes upper respiratory track infections and conjunctivitis in infected cattle. as a result of transient immune-suppression, bhv-1 infections can also lead to life-threatening secondary bacterial pneumonia that is referred to a ... | 2011 | 21689696 |
| the p53 tumor suppressor is stabilized by inhibitor of growth 1 (ing1) by blocking polyubiquitination. | the inhibitor of growth tumor suppressors (ing1-ing5) affect aging, apoptosis, dna repair and tumorigenesis. plant homeodomains (phd) of ing proteins bind histones in a methylation-sensitive manner to regulate chromatin structure. ing1 and ing2 contain a polybasic region (pbr) adjacent to their phds that binds stress-inducible phosphatidylinositol monophosphate (ptin-mp) signaling lipids to activate these ings. ing1 induces apoptosis independently of p53 but other studies suggest proapoptotic in ... | 2011 | 21731648 |
| the polymorphic hcmv glycoprotein ul20 is targeted for lysosomal degradation by multiple cytoplasmic dileucine motifs. | human cytomegalovirus (hcmv) is a widespread and persistent beta-herpesvirus. the large dna genome of hcmv encodes many proteins that are non-essential for viral replication including numerous proteins subverting host immunosurveillance. one of them is the barely characterized ul20, which is encoded adjacent to the well-defined immunoevasins ul16 and ul18. ul20 is a type i transmembrane glycoprotein with an immunoglobulin-like ectodomain that is highly polymorphic among hcmv strains. here, we sh ... | 2011 | 21689255 |
| differentiated neuroblastoma cells provide a highly efficient model for studies of productive varicella-zoster virus infection of neuronal cells. | varicella-zoster virus (vzv) is a highly species-specific herpesvirus which targets sensory ganglionic neurons. this species specificity has limited the study of many aspects of vzv pathogenesis, including neuronal infection. we report development of a highly efficient neuroblastoma cell model to study productive vzv infection of neuronal cells. we show that differentiation of sh-sy5y neuroblastoma cells yields a homogenous population of neuronal-like cells that are permissive to the full vzv re ... | 2011 | 21632750 |
| metastatic kaposi's sarcoma with perirectal involvement diagnosed with endoscopic ultrasound-guided echobrush cytology sampling. | aids-related kaposi's sarcoma (ks) is a low-grade vascular tumor that occurs in association with human herpesvirus 8 infection. here we report the case of a 21-year-old male with recently diagnosed cutaneous ks who presented with rectal bleeding and anal pruritus. initial endoscopic evaluation was nondiagnostic. ct imaging showed diffuse lymphadenopathy including perirectal involvement which was suspicious for metastatic ks. echoendoscopy with needle biopsies and echobrush sampling of the lymph ... | 2011 | 21829398 |
| treatment with valacyclovir, famciclovir, or antiretrovirals reduces human herpesvirus-8 replication in hiv-1 seropositive men. | human herpesvirus-8 (hhv-8) replication is a key factor in kaposi sarcoma, primary effusion lymphoma, and castleman disease pathogenesis. in vitro data suggest that antivirals inhibit hhv-8 replication, but little data exist in humans. daily oropharyngeal swabs were analyzed from hiv/hhv-8 dually infected men enrolled in three previous clinical trials of valacyclovir and famciclovir for hiv-1 and/or hsv-2 suppression. fifty-eight participants contributed 6,036 swabs. hhv-8 was detected in 1,128 ... | 2011 | 21837785 |
| pseudorabies virus in wild swine: a global perspective. | suid herpesvirus 1 (suhv1, syn. aujeszky's disease virus [adv] or pseudorabies virus [prv]), which belongs to the family herpesviridae, subfamily alphaherpesvirinae, genus varicellovirus is the causative agent of aujeszky's disease (ad, pseudorabies), a notifiable disease, that causes substantial economic losses to the swine industry in countries, where ad is present. members of the family suidae (true pigs) are the only natural hosts for prv, although the virus can infect numerous other mammals ... | 2011 | 21837416 |
| retroviral expression of mir2 decreases both surface mhc class i and the alloimmune ctl response. | the immune response to allogeneic cells in tissue-engineered constructs is a major barrier to their successful application in the treatment of many human diseases. specifically, the t cell-mediated immune response, initiated through the recognition of cell surface mhci molecules, is the primary cause of acute cellular allograft rejection. in this study, we altered expression of mhci through viral immunomodulatory mechanisms to examine whether allogeneic cells could be made to 'mimic' viral evasi ... | 2011 | 21695793 |
| common, emerging, vector-borne and infrequent abortogenic virus infections of cattle. | this review deals with the aetiology and the diagnosis of bovine viral abortion. while the abortion rates on beef and dairy cattle farms usually do not exceed 10%, significant economic losses because of abortion storms may be encountered. determining the cause of abortions is usually a challenge, and it generally remains obscure in more than 50% of the necropsy submitted foetuses. bovine viral diarrhoea virus and bovine herpesvirus-1 are the most common viruses causally associated with bovine ab ... | 2011 | 21733134 |
| inhibition of primary effusion lymphoma engraftment in scid mice by morpholino oligomers against early lytic genes of kaposi's sarcoma-associated herpesvirus. | kaposi's sarcoma-associated herpesvirus (kshv) is associated with several malignant diseases, including kaposi's sarcoma, primary effusion lymphoma (pel) and multicentric castleman's disease. the objectives of this study were to investigate the use of peptide-conjugated phosphorodiamidate morpholino oligomers (ppmos) against kshv early lytic genes and to assess their efficacy in severe combined immunodeficiency disease (scid) mice against pel engraftment. ppmos are short, single-stranded dna ana ... | 2011 | 21817187 |
| ostreid herpesvirus 1 detection and relationship with crassostrea gigas spat mortality in france between 1998 and 2006. | abstract: since its molecular characterisation, ostreid herpesvirus 1 (oshv-1) has been regularly detected in crassostrea gigas in france. although its pathogenicity was demonstrated on larval stages, its involvement during mortality outbreaks at the juvenile stage was highly suspected but not evidenced. to investigate mortality outbreaks, the french national network for surveillance and monitoring of mollusc health (repamo) carried out two surveys in juvenile c. gigas. the first survey lasted f ... | 2011 | 21635731 |