Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| genome-wide analysis of epstein-barr virus identifies variants and genes associated with gastric carcinoma and population structure. | epstein-barr virus is a ubiquitous virus and is associated with several human malignances, including the significant subset of gastric carcinoma, epstein-barr virus-associated gastric carcinoma. some epstein-barr virus-associated diseases are uniquely prevalent in populations with different geographic origins. however, the features of the disease and geographically associated epstein-barr virus genetic variation as well as the roles that the variation plays in carcinogenesis and evolution remain ... | 2017 | 29034771 |
| the infectious basis of acpa-positive rheumatoid arthritis. | rheumatoid arthritis (ra) is associated with hla-drb1 shared epitope (hla-drb1se) and anti-citrullinated protein autoantibodies (acpas). acpas precedes the onset of clinical and subclinical ra. there are strong data for three infectious agents as autoimmunity triggers in ra, namely porphyromonas gingivalis and aggregatibacter actinomycetemcomitans causes of periodontal disease (pd), and epstein-barr virus (ebv). p. gingivalis expresses arginine gingipains, that cleave proteins at the arginine re ... | 2017 | 29033912 |
| determination of molecular subtypes of diffuse large b-cell lymphoma using a reverse transcriptase multiplex ligation-dependent probe amplification classifier: a calym study. | diffuse large b-cell lymphoma (dlbcl) is the most common non-hodgkin lymphoma. it includes three major subtypes termed germinal center b-cell-like, activated b-cell-like, and primary mediastinal b-cell lymphoma. with the emergence of novel targeted therapies, accurate methods capable of interrogating this cell-of-origin classification should soon become essential in the clinics. to address this issue, we developed a novel gene expression profiling dlbcl classifier based on reverse transcriptase ... | 2017 | 29054399 |
| murine gammaherpesvirus 68: a small animal model for gammaherpesvirus-associated diseases. | murine gammaherpesvirus 68 (mhv68) is a naturally occurring pathogen of murid rodents that is genetically related to the human gammaherpesviruses epstein-barr virus (ebv) and kaposi sarcoma-associated herpesvirus (kshv). viral, immunologic, and disease parameters following experimental infection of laboratory mice with mhv68 closely resemble what occurs during primary ebv infection of humans, which suggests that mhv68 infection of mice offers a small animal model to study in general the pathogen ... | 2017 | 29052141 |
| ebv infection and glucose metabolism in nasopharyngeal carcinoma. | to establish persistent infection in cells, viruses evolve strategies to alter host cellular pathways to regulate cell proliferation and energy metabolism which support viral infection. epstein-barr virus (ebv) undergoes both lytic and latent infection to achieve persistent and lifelong infection in human. ebv readily infects human b cells, driving their transformation to proliferative lymphoblastoid cell lines (lcl), and eventually establishes lifelong latent infection in memory b cells. in con ... | 2017 | 29052133 |
| current progress in ebv-associated b-cell lymphomas. | epstein-barr virus (ebv) was the first human tumor virus discovered more than 50 years ago. ebv-associated lymphomagenesis is still a significant viral-associated disease as it involves a diverse range of pathologies, especially b-cell lymphomas. recent development of high-throughput next-generation sequencing technologies and in vivo mouse models have significantly promoted our understanding of the fundamental molecular mechanisms which drive these cancers and allowed for the development of the ... | 2017 | 29052132 |
| magt1-mediated disturbance of mg2+ homeostasis lead to exhausted of hbv-infected nk and cd8+ t cells. | the magnesium transporter 1 (magt1) is a critical regulator of basal intracellular free magnesium ([mg2+]i) levels. it has been shown that magt1 was involved in the disorder in mg2+ homeostasis after epstein-barr virus (ebv) infection. here, we identified the effects of magt1-mediated disturbance of mg2+ homeostasis on chronic hepatitis b virus (hbv)-infected natural killer (nk) and cd8+ t cells. the expression of magt1 was gradually decreased with the increase of infected time in cd8+ t cells, ... | 2017 | 29051561 |
| characterization of the subcellular localization of epstein-barr virus encoded proteins in live cells. | epstein-barr virus (ebv) is the pathogenic factor of numerous human tumors, yet certain of its encoded proteins have not been studied. as a first step for functional identification, we presented the construction of a library of expression constructs for most of the ebv encoded proteins and an explicit subcellular localization map of 81 proteins encoded by ebv in mammalian cells. viral open reading frames were fused with enhanced yellow fluorescent protein (eyfp) tag in eukaryotic expression plas ... | 2017 | 29050259 |
| rare case of pulmonary lymphomatoid granulomatosis in conjunction with tuberculosis: a case report. | lymphomatoid granulomatosis is a very rare epstein-barr virus-driven lymphoproliferative disease. this disease has high mortality owing to its low incidence in conjunction with nonspecific presentations, which contribute to delays in diagnosis. | 2017 | 29049243 |
| chronic active epstein-barr virus infection as the initial symptom in a janus kinase 3 deficiency child: case report and literature review. | with the progress of sequencing technology, an increasing number of atypical primary immunodeficiency (pid) patients have been discovered, including janus kinase 3 (jak3) gene deficiency. | 2017 | 29049190 |
| gastric cancer: immunohistochemical classification of molecular subtypes and their association with clinicopathological characteristics. | gastric cancer is traditionally divided into intestinal and diffuse histological subtypes, but recent molecular analyses have led to novel classification proposals based on genomic alterations. while the intestinal- and diffuse-type tumours are distinguishable from each other at the molecular level, intestinal-type tumours have more diverse molecular profile. the technology required for comprehensive molecular analysis is expensive and not applicable for routine clinical diagnostics. in this stu ... | 2017 | 29046940 |
| [differential diagnosis of mediastinal and hilar lymphadenopathy with focus on occupational diseases]. | hilar and mediastinal lymphadenopathy may represent a diagnostic challenge in clinical practice. this article is intended to facilitate differential diagnosis by a systematic description of relevant pathologies, notably with occupational etiology. clinical findings of relevant diseases, i. e. of tuberculosis, chronic beryllium disease, sarcoidosis, lung cancer, malignant lymphoma, epstein-barr virus infection, and histoplasmosis are compared.case history, imaging and laboratory tests have import ... | 2017 | 29046010 |
| primary central nervous system extranodal nasal-type natural killer/t-cell lymphoma with cd20 expression. | we report a unique case of primary cns extranodal natural killer/t-cell lymphoma (pcns enktcl) with cd20 expression and the monoclonal rearrangement of ig heavey chain (igh) gene. resection specimens were evaluated using he-stained sections, immunohistochemistry, in situ hybridization and pcr. histopathologic examination, immunohistochemistry and molecular studies showed the intermediate-sized lymphoma cells expressing cd2, cd3ε, granzyme b, tia-1, cd20 and epstein-barr virus-encoded rna, with g ... | 2017 | 29063643 |
| analysis of immunogenicity of intracellular ctar fragments of epstein-barr virus latent phase protein lmp1. | intracellular fragments of latent phase protein lmp1 of epstein-barr virus, denoted as ctar1/2/3, can trigger a variety of cell cascades and contribute to the transforming potential of the virus. generation of recombinant proteins ctar1/2/3 is expected to yield more ample data on functional and immunogenic characteristics of lmp1. we created genetic constructs for prokaryotic expression of lmp1 ctar fragments and selected optimal conditions for their production and purification. using a new libr ... | 2017 | 29063322 |
| diabetes and risk of kaposi's sarcoma: effects of high glucose on reactivation and infection of kaposi's sarcoma-associated herpesvirus. | patients with diabetes are generally prone to pathogen infection and tumor progression. here, we investigated the potential association between diabetes and kaposi's sarcoma (ks), a tumor linked to infection with kaposi's sarcoma-associated herpesvirus (kshv). by using taiwan's national health insurance research database, we found that diabetes is statistically associated with increased risk of ks in a case-control study. since a high level of blood sugar is the hallmark of diabetes, we determin ... | 2017 | 29113328 |
| elevated expression of ebv and tlrs in the brain is associated with rasmussen's encephalitis. | rasmussen's encephalitis (re) is a rare pediatric neurological disorder, the etiology of which remains unclear. it has been speculated that the immunopathogenesis of re involves damage to neurons, which eventually leads to the occurrence of re. viral infection may be a critical factor in triggering re immunopathogenesis. in this study, we analyzed the expression of epstein-barr virus (ebv) antigens as well as of toll-like receptor 3 (tlr3), tlr9, and downstream adapter tirdomain-containing adapt ... | 2017 | 29116594 |
| the regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers. | activation of specific sets of protein kinases by intracellular signal molecules has become more and more apparent in the past decade. phosphorylation, one of key posttranslational modification events, is activated by kinase or regulatory protein and is vital for controlling many physiological functions of eukaryotic cells such as cell proliferation, differentiation, malignant transformation, and signal transduction mediated by external stimuli. moreovers, the reversible modification of phosphor ... | 2017 | 29116588 |
| prognostic value of plasma epstein-barr virus dna level during posttreatment follow-up in the patients with nasopharyngeal carcinoma having undergone intensity-modulated radiotherapy. | the value of epstein-barr virus (ebv) dna assay during posttreatment follow-up of the patients with nasopharyngeal carcinoma (npc) presenting with different pretreatment plasma ebv dna levels remains unclear. in the present study, we aimed to evaluate the prognostic value of plasma ebv dna assay during posttreatment follow-up in the patients with npc who have undergone intensity-modulated radiotherapy. | 2017 | 29116021 |
| identification of epstein-barr virus in the human placenta and its pathologic characteristics. | epstein-barr virus (ebv), a common pathogen in humans, is suspected as the cause of multiple pregnancy-related pathologies including depression, preeclampsia, and stillbirth. moreover, transmission of ebv through the placenta has been reported. however, the focus of ebv infection within the placenta has remained unknown to date. in this study, we proved the expression of latent ebv genes in the endometrial glandular epithelial cells of the placenta and investigated the cytological characteristic ... | 2017 | 29115077 |
| risk factors and clinical outcomes of pediatric liver transplant recipients with post-transplant lymphoproliferative disease in a multi-ethnic asian cohort. | we aimed to evaluate clinical characteristics, risk factors, and disease outcomes for liver transplant recipients (ltr) with post-transplant lymphoproliferative disease (ptld) at our center. | 2017 | 29071779 |
| two cases of angioimmunoblastic t-cell lymphoma with concomitant positive serology for acute epstein-barr virus infection. | 2017 | 29071053 | |
| managing epstein-barr virus and other risk factors in ms-future perspectives. | here, we discuss the rationale and feasibility of treatment directed against the modifiable risk factors in multiple sclerosis. the established environmental risk factors vitamin d insufficiency, cigarette smoke exposure, adolescence overweight, and epstein-barr virus infection are reviewed. already available measures to target these risk factors are discussed. | 2017 | 29068493 |
| is the hygiene hypothesis relevant for the risk of multiple sclerosis? | the hygiene hypothesis, suggesting that low exposure to pathogens early in life can increase the risk for immune-mediated diseases, has been proposed as an explanation for the increase in incidence of allergy and autoimmune diseases in industrialized countries during the last decades. several aspects of the hygiene hypothesis have been related to ms. already in 1966, the risk of ms was suggested to be higher in individuals with high hygienic standard during childhood. further, an episode of infe ... | 2017 | 29068485 |
| the perivascular microenvironment in epstein-barr virus positive primary central nervous system lymphoma: the role of programmed cell death 1 and programmed cell death ligand 1. | it has been shown that high expression of certain immune checkpoint molecules, including those of the programmed death protein 1/programmed death ligand 1 (pd-1/pd-l1) axis, can be utilized to regulate immunosuppression in the microenvironment of malignant neoplasms. for the purpose of clarifying the immune-escape mechanism of primary central nervous system lymphomas (pcnsls), particularly in epstein-barr virus (ebv)-positive cases, markers for pd-1, pd-l1, tumor-associated macrophages (tams), a ... | 2017 | 29067721 |
| iatrogenic solid tumors following immunosuppressive therapy. | immunosuppression induced by chronic medication, such as occurs post-transplantation, may increase a patient's risk of developing solid tumors. these are often rare tumors characterized by odd presentations. this review focuses on commonly encountered iatrogenic, non-hematopoietic solid tumors following immunotherapy and provides a practical approach to their diagnosis. all of the malignancies covered in this review are viral-induced. they include human papillomavirus (hpv)-associated carcinomas ... | 2017 | 29066044 |
| the battle of rna synthesis: virus versus host. | transcription control is the foundation of gene regulation. whereas a cell is fully equipped for this task, viruses often depend on the host to supply tools for their transcription program. over the course of evolution and adaptation, viruses have found diverse ways to optimally exploit cellular host processes such as transcription to their own benefit. just as cells are increasingly understood to employ nascent rnas in transcription regulation, recent discoveries are revealing how viruses use n ... | 2017 | 29065472 |
| gammaherpesviral tegument proteins, pml-nuclear bodies and the ubiquitin-proteasome system. | gammaherpesviruses like epstein-barr virus (ebv) and kaposi's sarcoma-associated herpesvirus (kshv) subvert the ubiquitin proteasome system for their own benefit in order to facilitate viral gene expression and replication. in particular, viral tegument proteins that share sequence homology to the formylglycineamide ribonucleotide amidotransferase (fgarat, or pfas), an enzyme in the cellular purine biosynthesis, are important for disrupting the intrinsic antiviral response associated with promye ... | 2017 | 29065450 |
| epstein-barr virus infection and oral squamous cell carcinoma risk: a meta-analysis. | the evidence for association between epstein-barr virus (ebv) infection and risk of oral squamous cell carcinoma (oscc) is inconsistent in the literature. therefore, this meta-analysis was conducted to clarify this association. | 2017 | 29065191 |
| evaluation of pd1/pdl1 expression and their clinicopathologic association in ebv-associated lymphoproliferative disorders in nonimmunosuppressed patients. | epstein-barr virus (ebv)-associated lymphoproliferative disorders (lpd)/lymphomas in nonimmunosuppressed patients represent a unique entity and have been proposed to be related to immune senescence. engagement of programmed cell death 1 (pd1) by its ligand programmed death ligand 1 (pdl1) inhibits t-cell activation, and leads to t-cell exhaustion. in clinical trials, therapeutic antibodies that block the pd1-pdl1 axis have shown promising therapeutic activity in certain types of lymphomas. altho ... | 2017 | 29084057 |
| [advances on epstein-barr virus related post-transplant lymphoproliferative disorders after allogeneic hematopoietic stem cell transplantation]. | 2017 | 29081206 | |
| [clinical features of mononucleosis because of epstein-barr virus and cytomegalovirus co-infection in adult patients]. | objective: to identify the clinical features of mononucleosis caused by co-infection of epstein-barr virus (ebv) and cytomegalovirus (cmv) in adult patients. methods: a total of 103 inpatients with mononucleosis in peking university third hospital from may 2013 to may 2016 were collected as the study subjects.the patients were divided into three groups according to the responsible pathogens: 33 patients infected with ebv and cmv, 53 infected with ebv alone and 17 infected with cmv alone.furtherm ... | 2017 | 29081150 |
| cytokines associated with burkitt's lymphoma in western kenya. | burkitt's lymphoma (bl) is a common aggressive non-hodgkin's lymphoma in east and central africa among children. persistent infections with epstein barr virus or plasmodium falciparum are associated with immune hyperstimulation. it is hypothesised that inadvertent cytokine responses to infections indirectly or directly influence b cell neoplastic transformation through c-myelocytomatosis (c-myc) gene translocation. we sought to describe cytokines in children and adolescents with bl. participants ... | 2017 | 29078819 |
| is epstein-barr virus infection associated with the pathogenesis of microscopic colitis? | epstein-barr virus (ebv) has been associated with inflammation in the colon, particularly in patients with inflammatory bowel disease (ibd). even if a relevant plasmocytosis, similar to ibd, is present in microscopic colitis (mc), the frequency of ebv infection in this setting is unknown. | 2017 | 29078077 |
| 18f-fdg pet for detection of primary tracheobronchial t-/natural killer-cell-derived posttransplant lymphoproliferative disorder after lung transplantation. | posttransplant lymphoproliferative disorder (ptld) is a rare, but potentially devastating complication of solid organ transplantation. epstein-barr virus-associated ptlds of t-cell origin are exceedingly rare. we present the case of a 20-year-old man with extranasal t-/natural killer-cell-derived ptld after lung transplantation who underwent an f-fdg pet/ct scan for staging of disease. the f-fdg-pet scan demonstrated an unusual pattern of lymphomatous involvement limited to the recipients trache ... | 2017 | 29076909 |
| multiple oncogenic viruses are present in human breast tissues before development of virus associated breast cancer. | multiple oncogenic viruses including, mouse mammary tumor virus, bovine leukemia virus, human papilloma virus, and epstein barr virus, have been identified as separate infectious pathogens in human breast cancer. here we demonstrate that these four viruses may be present in normal and benign breast tissues 1 to 11 years before the development of same virus breast cancer in the same patients. | 2017 | 29075317 |
| serology of viral infections and tuberculosis screening in an ibd population referred to a tertiary centre of southern italy. | with the introduction of more potent immunosuppressive agents in inflammatory bowel disease, prevention of opportunistic infections has become necessary by introducing screening programs. prevalence of the most important infectious agents may vary in different geographical areas. the aim of our study was to assess the immune status for hepatitis b, varicella, mononucleosis, and cytomegalovirus infection together with the determination of the hepatitis c and tuberculosis status in southern italy. | 2017 | 29075289 |
| protective effect of rituximab in chronic graft-versus-host disease occurrence in allogeneic transplant patients with epstein barr virus viremia. | b cells are involved in chronic graft-versus-host disease (cgvhd) pathogenesis, and rituximab may have a therapeutic effect on cgvhd in allogeneic hematopoietic stem cell transplantation (allo-hsct) patients. herein, we retrospectively evaluated the prophylactic effect of rituximab on cgvhd in a group of chinese allo-hsct patients. a total of 102 patients, who suffered epstein barr virus (ebv) viremia within 100 days after allo-hsct, were included in this study. fifty patients received rituximab ... | 2017 | 29075063 |
| ebv latent membrane protein 2a orchestrates p27kip1 degradation via cks1 to accelerate myc-driven lymphoma in mice. | epstein-barr virus (ebv) establishes lifelong infection in b lymphocytes of most human hosts and is associated with several b lymphomas. during latent infection, ebv encodes latent membrane protein 2a (lmp2a) to promote the survival of b cells by mimicking host b-cell receptor signaling. by studying the roles of lmp2a during lymphoma development in vivo, we found that lmp2a mediates rapid myc-driven lymphoma onset by allowing b cells to bypass myc-induced apoptosis mediated by the p53 pathway in ... | 2017 | 29074502 |
| intratumoural pd-l1 expression is associated with worse survival of patients with epstein-barr virus-associated gastric cancer. | this study investigated the clinical relevance and prognostic impact of the overall expression of programmed cell death protein ligand-1 (pd-l1) and programmed cell death protein ligand-2 (pd-l2), in patients with epstein-barr virus-associated gastric cancer (ebvagc). | 2017 | 29073638 |
| the epstein-barr virus b-zip protein zta recognizes specific dna sequences containing 5-methylcytosine and 5-hydroxymethylcytosine. | the epstein-barr virus (ebv) b-zip transcription factor zta binds to many dna sequences containing methylated cg dinucleotides. using protein binding microarrays (pbms), we analyzed the sequence specific dna binding of zta to four kinds of double-stranded dna (dsdna): (1) dna containing cytosine in both strands, (2) dna with 5-methylcytosine (5mc) in one strand and cytosine in the second strand, (3) dna with 5-hydroxymethylcytosine (5hmc) in one strand and cytosine in the second strand, and (4) ... | 2017 | 29072898 |
| characterization of an anti-fetal achr monoclonal antibody isolated from a myasthenia gravis patient. | we report here the sequence and functional characterization of a recombinantly expressed autoantibody (mab 131) previously isolated from a myasthenia gravis patient by immortalization of thymic b cells using epstein-barr virus and tlr9 activation. the antibody is characterized by a high degree of somatic mutations as well as a 6 amino acid insertion within the vhcdr2. the recombinant mab 131 is specific for the γ-subunit of the fetal achr to which it bound with sub-nanomolar apparent affinity, a ... | 2017 | 29089519 |
| actionable gene-based classification toward precision medicine in gastric cancer. | intertumoral heterogeneity represents a significant hurdle to identifying optimized targeted therapies in gastric cancer (gc). to realize precision medicine for gc patients, an actionable gene alteration-based molecular classification that directly associates gcs with targeted therapies is needed. | 2017 | 29089060 |
| the conundrum of the epstein-barr virus-associated gastric carcinoma in the americas. | epstein-barr virus-associated gastric carcinoma shows a higher prevalence in the americas than asia. we summarize all studies of epstein barr virus-associated gastric carcinoma in the americas, focusing on host characteristics, environmental associations and phylogeographic diversity of epstein-barr virus strains. in the americas, the prevalence of epstein barr virus-associated gastric carcinoma is 11.4%, more frequent in males and portray predominantly diffuse-type histology. ebers, ebnas, bart ... | 2017 | 29088902 |
| irak4 is essential for tlr9-induced suppression of epstein-barr virus bzlf1 transcription in akata burkitt's lymphoma cells. | burkitt's lymphoma (bl) is the most common childhood cancer in equatorial africa, and is endemic to areas where people are chronically co-infected with epstein-barr virus (ebv) and the malaria pathogen plasmodium falciparum. the contribution of these pathogens in the oncogenic process remains poorly understood. we showed earlier that the activation of toll-like receptor (tlr) 9 by hemozoin, a disposal product formed from the digestion of blood by p. falciparum, suppresses the lytic reactivation ... | 2017 | 29088270 |
| adenovirus-associated acute appendicitis: an under-recognized relationship? | acute appendicitis (aa) is one of the most common causes of a surgical abdomen worldwide, occurring most frequently in those age 10 to 29 years. adenovirus (adv) is a rare but reported cause of aa in children and a well-recognized cause of intussusception in infants and young children. annually, about 36,000 basic military trainees (bmts) undergo initial training at joint base san antonio lackland, texas. before reintroduction of the adv 4/7 vaccine in november 2011, one-third of bmts developed ... | 2017 | 29087922 |
| epstein-barr virus brlf1 induces genomic instability and progressive malignancy in nasopharyngeal carcinoma cells. | nasopharyngeal carcinoma (npc) is a serious health problem in china and southeast asia. relapse is the major cause of mortality, but mechanisms of relapse are mysterious. epstein-barr virus (ebv) reactivation and host genomic instability (gi) have correlated with npc development. previously, we reported that lytic early genes dnase and balf3 induce genetic alterations and progressive malignancy in npc cells, implying lytic proteins may be required for npc relapse. in this study, we show that imm ... | 2017 | 29108278 |
| lymphoproliferative disorders with concurrent hhv8 and ebv infection: beyond primary effusion lymphoma and germinotropic lymphoproliferative disorder. | lymphoproliferative disorders (lpd) characterised by human herpesvirus 8 (hhv8) and epstein-barr virus (ebv) infection are rare and two entities are included in the world health organisation classification: primary effusion lymphoma (pel) and germinotropic lpd. these two entities have very different clinicopathological presentations and prognosis. here we describe two cases of hhv8-positive, ebv-positive lymphoma with clinicopathological features that are not consistent with either pel or germin ... | 2017 | 29105119 |
| pathogenic role of exosomes in epstein-barr virus (ebv)-associated cancers. | exosomes are 40- to 100-nm membrane-bound small vesicles that carry a great variety of cellular cargoes including proteins, dna, messenger rnas (mrnas), and micrornas (mirnas). these nanovesicles are detected in various biological fluids such as serum, urine, saliva, and seminal fluids. exosomes serve as key mediators in intercellular communication by facilitating the transfer and exchange of cellular components from cells to cells. they contain various pathogenic factors whereby their adverse e ... | 2017 | 29104494 |
| association between epstein barr virus and tongue squamous cell carcinoma in iranian patients. | detection of epstein-barr virus in oral squamous cell carcinoma suggests its involvement in the carcinogenesis of oral cavity. but, there are few studies on the incidence of ebv genome in squamous cell carcinomas at specific locations in the oral cavity like tongue and with different tumor progression. in this study the presence of ebv genome in tongue squamous cell carcinoma (tscc) in iranian patients were investigated. accordingly, a total of 94 cases with tscc were firstly analyzed for the pr ... | 2017 | 29103768 |
| single nucleotide polymorphism rs2274084 of gap junction protein beta 2 gene among epstein-barr virus-associated tumors. | gap junction protein beta 2 gene (gjb2) encodes one of connexins- connexin 26 (cx26), which mainly expressed in epithelial cells. cx26 is usually considered a channel to exchange information between cells, which plays a critical role in tumor cell proliferation. | 2017 | 29103018 |
| a rare localised nasal cd30+ primary cutaneous t-cell lymphoma following liver transplantation. | cutaneous t-cell post-transplant lymphoproliferative disorder (ptld) is a rare clinical presentation that can potentially turn aggressive in solid-organ transplant recipients if not detected and intervened on early. we encountered a rare case of rapidly worsening primary cutaneous cd30-positive, epstein-barr virus-negative anaplastic large cell lymphoma (alcl) of t-cell origin, manifesting as an isolated nasal tip lesion in a 71-year-old man 4 years after orthotopic liver transplantation. excisi ... | 2017 | 29103006 |
| early disseminated lyme disease masquerading as mononucleosis: a case report. | disseminated lyme disease can be difficult to diagnose, as it begins with nonspecific signs and symptoms, which, if not treated correctly, can lead to atrioventricular conduction blocks and meningitis. in addition, the diagnosis can be further complicated by potentially false-positive test results. | 2017 | 29102094 |
| how immunologic and genetic biomarkers impact hodgkin lymphoma classification, diagnosis, and management: a huge potential that yet needs to be exploited. | "ne è passata di acqua sotto i ponti." it has been a long time since the diagnosis of hodgkin lymphoma (hl) was exclusively based on the detection of typical reed-sternberg cells and the recognition of the characteristic morpho-histological background, as well as on the pathologist's skill. the discovery of immunologic, molecular genetic and virologic biomarkers has provided an objective contribution to the diagnosis and a scientific basis for a modern classification of hl. recent updates have c ... | 2017 | 29099538 |
| hodgkin's lymphoma arising in a case of mycosis fungoides: an unusual association. | mycosis fungoides is a cutaneous t-cell lymphoma with a high risk for developing secondary malignancies, especially b-cell lymphoproliferative disorders. about 40 cases of hodgkin's lymphoma associated with mycosis fungoides have been reported in literature till date. we report a case of a 35-year-old gentleman who presented with intensely itchy reddish lesions all over the body. multiple skin biopsies taken from the lesions on scalp and back confirmed the clinical diagnosis of mycosis fungoides ... | 2017 | 29098990 |
| epstein-barr virus dna load kinetics analysis in allogeneic hematopoietic stem cell transplant recipients: is it of any clinical usefulness? | there is a lack of clinical information regarding the usefulness of plasma epstein-barr virus (ebv) dna load kinetics analyses in the management of ebv infections in allogeneic hematopoietic stem cell transplantation (allo-hsct) recipients. namely, it remains unknown whether this type of analysis can help physicians to anticipate the development of high-level ebv dnaemia episodes requiring rituximab treatment or predict the risk of recurrent ebv dnaemia or post-transplant lymphoproliferative dis ... | 2017 | 29096390 |
| age-related macular degeneration: a connection between human herpes virus-6a-induced cd46 downregulation and complement activation? | viruses are able to interfere with the immune system by docking to receptors on host cells that are important for proper functioning of the immune system. a well-known example is the human immunodeficiency virus that uses cd4 cell surface molecules to enter host lymphocytes and thereby deleteriously destroying the helper cell population of the immune system. a more complicated mechanism is seen in multiple sclerosis (ms) where human herpes virus-6a (hhv-6a) infects astrocytes by docking to the c ... | 2017 | 29093709 |
| epstein-barr virus infection in multiple sclerosis patients. | multiple sclerosis (ms) is the most common inflammatory autoimmune cns disease, with unknown etiology. we aimed to determine the coexistence of ms with antibodies to epstein-barr virus and its gene sequences (ebna1 and bhrf1). the study included 60 ms patients and 60 control subjects. serum samples were processed by elisa for detection of ebv antibodies, and latent ebv genes were determined by real time pcr in blood samples. while 18 (30%) ms cases had anti- ebv igm antibodies, all controls were ... | 2017 | 29120577 |
| humanised mouse models for haematopoiesis and infectious diseases. | "humanised" mouse models have emerged over past years as powerful tools for investigating human haematopoiesis and immunity. they allowed the identification of key factors for the maintenance and function of normal and leukaemic human haematopoietic stem cells. these findings have been widely used to dissect the pathogenesis of multiple myeloid and lymphoid neoplasms, such as acute myeloid leukaemia and acute lymphoblastic leukaemia. furthermore, these models can serve as a stepping-stone to cli ... | 2017 | 29120027 |
| computer-aided design of an epitope-based vaccine against epstein-barr virus. | epstein-barr virus is a very common human virus that infects 90% of human adults. ebv replicates in epithelial and b cells and causes infectious mononucleosis. ebv infection is also linked to various cancers, including burkitt's lymphoma and nasopharyngeal carcinomas, and autoimmune diseases such as multiple sclerosis. currently, there are no effective drugs or vaccines to treat or prevent ebv infection. herein, we applied a computer-aided strategy to design a prophylactic epitope vaccine ensemb ... | 2017 | 29119120 |
| pediatric pulmonary epstein-barr virus-positive diffuse large b-cell lymphoma: a case report and review of the literature. | non-hodgkin's lymphoma (nhl) is a common malignancy of childhood; however, a lung primary presentation is an uncommon finding, as is finding an association with the epstein-barr virus (ebv). we report the case of a 23-month-old female who developed ebv-associated diffuse large b-cell lymphoma (dlbcl) that was initially thought to be pneumonia. extensive tissue necrosis, focal angioinvasion, and angiodestruction were observed. she was refractory to various therapy regimens, subsequently developed ... | 2017 | 29119031 |
| association of dna repair genes polymorphisms and mutations with increased risk of head and neck cancer: a review. | dna repair mechanisms allow maintain genomic stability and proper functioning within the cells. any aberrations may cause an increased risk of many diseases such as cancer. the most crucial risk factors for head and neck squamous cell carcinoma are behavioral factors, predominantly chronic exposure to tobacco, alcohol addiction, and infection with human papillomavirus or epstein-barr virus. these agents can induce dna damage; therefore, cells must activate appropriate mechanisms in order to func ... | 2017 | 29143133 |
| correction to: abstracts : 29th european congress of pathology. | in poster sessions, the first-author name was missing from the authorship group originally listed for abstract ps-13-001 (page s176), entitled "gastric carcinoma with lymphoid stroma: analysis of microsatellite instability and epstein-barr virus status". the correct authorship group is shown above. | 2017 | 29143111 |
| clinical and pathological characterization of epstein-barr virus-associated gastric carcinomas in portugal. | to determine the prevalence of epstein-barr virus (ebv)-associated gastric carcinomas in the north region of portugal and to study its clinicopathological characteristics. | 2017 | 29142476 |
| the epstein-barr virus episome maneuvers between nuclear chromatin compartments during reactivation. | the human genome is structurally organized in three-dimensional space to facilitate functional partitioning of transcription. we learned that the latent episome of the human epstein-barr virus (ebv) preferentially associates with gene-poor chromosomes and avoids gene-rich chromosomes. kaposi's sarcoma-associated herpesvirus behaves similarly, but human papillomavirus does not. contacts localize on the ebv side to orip, the latent origin of replication. this genetic element, and the ebna1 protein ... | 2017 | 29142137 |
| epstein-barr virus-positive mucocutaneous ulcer in a patient with polycythemia vera treated with oral hydroxyurea. | 2017 | 29139148 | |
| correction for ansari et al., "constitutive interferon-inducible protein 16-inflammasome activation during epstein-barr virus latency i, ii, and iii in b and epithelial cells". | 2017 | 29138330 | |
| programmed death ligand-1 and met co-expression is a poor prognostic factor in gastric cancers after resection. | programmed death-ligand 1 (pd-l1) plays an essential protein for immune evasion, contributing to tumor development and progression. recent studies have reported met as an upregulator for pd-l1 overexpression through an oncogenic pathway. however, an association between pd-l1 expression with met has not been reported in gastric cancer.the prognostic significance of pd-l1 and its association with epstein-barr virus (ebv), microsatellite instability (msi), and mucin phenotype remain controversial. ... | 2017 | 29137273 |
| ebv and apoptosis: the viral master regulator of cell fate? | epstein-barr virus (ebv) was first discovered in cells from a patient with burkitt lymphoma (bl), and is now known to be a contributory factor in 1-2% of all cancers, for which there are as yet, no ebv-targeted therapies available. like other herpesviruses, ebv adopts a persistent latent infection in vivo and only rarely reactivates into replicative lytic cycle. although latency is associated with restricted patterns of gene expression, genes are never expressed in isolation; always in groups. h ... | 2017 | 29137176 |
| [the prognostic significance of plasma epstein-barr virus dna in patients with diffuse large b cell lymphoma]. | to retrospectively analyze the prognostic significance of plasma epstein-barr virus (ebv) dna in 122 patients with diffuse large b cell lymphoma (dlbcl). plasma ebv dna positivity was related to advanced disease stage (p=0.030), b symptoms (p=0.004) and elevated serum lactic dehydrogenase (ldh) (p=0.001). furthermore, univariate analysis indicated that plasma ebv dna level was associated with worse overall survival (os) (hr=0.223, 95%ci 0.096-0.518, p<0.001) and worse progression free survival ( ... | 2017 | 29136714 |
| unsuspected lymphomatoid granulomatosis in a patient with antisynthetase syndrome. | clinical diagnosis of lymphomatoid granulomatosis (lyg) often is difficult, especially in patients with multiple comorbidities. we present a 60-year-old woman with worsening fatigue, night sweats, unintentional weight loss, and dyspnea of 2 weeks' duration. her medical history was remarkable for recent radiation therapy for recurrent breast cancer and antisynthetase syndrome complicated by interstitial lung disease and controlled with azathioprine. computed tomography showed ground-glass opaciti ... | 2017 | 29136066 |
| latent membrane protein 1 is a novel determinant of epstein-barr virus genome persistence and reactivation. | epstein-barr virus (ebv) is a ubiquitous gammaherpesvirus that persistently infects humans, with nearly 95% seropositivity in adults. infection in differentiating epithelia is permissive, but ebv-associated nasopharyngeal carcinoma (npc) tumors harbor a clonal and nonproductive latent infection. however, in explanted npc cultures and epithelial cell lines, episomal ebv genomes are frequently lost. the resulting unstable infection has hampered efforts to study the determinants of ebv persistence ... | 2017 | 29134204 |
| interferon-γ-inducible protein 16 (ifi16) is required for the maintenance of epstein-barr virus latency. | epstein-barr virus (ebv) exhibits both lytic and latent (lat. i, ii, and iii) phases in an infected individual. it's during the latent phase of ebv that all ebv-associated cancers, including burkitt's lymphoma, nasopharyngeal carcinoma and lymphoproliferative disease arise. interferon-γ-inducible protein 16 (ifi16) is a well-established innate immune sensor and viral transcriptional regulator involved in response to invading dna viruses. during latency, ifi16 remains in the nucleus, in part boun ... | 2017 | 29132393 |
| a dramatic case of odynophagia. | we report the case of a 77-year-old male with a history of aortic stenosis and interstitial lung disease, who debuted 3 years ago with an outbreak of necrotic and very painful canker sores. the severity of the lesions and their refractory response to treatment led to several hospital admissions and multiple consultations to different specialists (ent, rheumatology, dermatology, ophthalmology, cardiology, and internal medicine). during this time, the patient received central parenteral nutrition ... | 2017 | 29128948 |
| posttransplant lymphoproliferative disorder in solid organ and hematopoietic stem cell transplantation. | posttransplant lymphoproliferative disorders (ptld) represent an immunosuppression-related lymphoid or plasmacytic proliferation that occur in the setting of solid organ transplant or allogeneic hematopoietic stem cell transplantation (hsct). ptld is a devastating consequence of hsct and solid organ transplantation with a high morbidity and mortality. most commonly, ptld is related to epstein-barr virus (ebv) infection, but an increasing number of non-ebv-related cases are occurring. initial the ... | 2017 | 29128025 |
| gastric carcinomas with lymphoid stroma: categorization and comparison with solid-type colonic carcinomas. | to determine whether histologic features could help identify gastric carcinomas with lymphoid stroma associated with microsatellite instability (msi) (ie, "medullary carcinomas"), epstein-barr virus (ebv) infection (termed lymphoepithelioma-like carcinomas in other organ systems), or neither. | 2017 | 29126141 |
| assessment of the combined effect of epstein-barr virus and plasmodium falciparum infections on endemic burkitt lymphoma using a multiplex serological approach. | epstein-barr virus (ebv) is a necessary cause of endemic burkitt lymphoma (ebl), while the role of plasmodium falciparum in ebl remains uncertain. this study aimed to generate new hypotheses on the interplay between both infections in the development of ebl by investigating the igg and igm profiles against several ebv and p. falciparum antigens. serum samples collected in a childhood study in malawi (2005-2006) from 442 hiv-seronegative children (271 ebl cases and 171 controls) between 1.4 and 1 ... | 2017 | 29123514 |
| encephalitis treatment - a case report with long-term follow-up of ebv pcr in cerebrospinal fluid. | epstein-barr virus (ebv) has been found to cause infectious mononucleosis multiple times, but has been associated rarely with ebv encephalitis. also, whenever it is diagnosed, it is always treated symptomatically. | 2017 | 29123419 |
| epstein-barr virus hijacks dna damage response transducers to orchestrate its life cycle. | the epstein-barr virus (ebv) is a ubiquitous virus that infects most of the human population. ebv infection is associated with multiple human cancers, including burkitt's lymphoma, hodgkin's lymphoma, a subset of gastric carcinomas, and almost all undifferentiated non-keratinizing nasopharyngeal carcinoma. intensive research has shown that ebv triggers a dna damage response (ddr) during primary infection and lytic reactivation. the ebv-encoded viral proteins have been implicated in deregulating ... | 2017 | 29144413 |
| [atypical profile problem in serological diagnosis of ebv]. | epstein-barr virus (ebv) is the causative agent of infectious mononucleosis. burkitt's lymphoma, nasopharyngeal carcinoma and post-transplant lymphoproliferative diseases are also associated with ebv. diagnosis is frequently based on detection of specific antibodies. using three parameters (anti vca-igm, anti vca-igg and anti ebna-1 igg), it is possible to define infection status and diagnose acute or past infection. however, sometimes the detection of atypical serological profiles makes it diff ... | 2017 | 29153068 |
| host immune response index in gastric cancer identified by comprehensive analyses of tumor immunity. | tumor infiltrating lymphocytes (til) in epstein-barr virus (ebv)-associated/microsatellite-unstable (msi) gastric carcinomas (gc) constitute immune-active principal cellular components of tumor microenvironment and contribute to better prognosis. with the remarkable success of cancer immunotherapies, there is an urgent need for a comprehensive understanding of tumor-immune interactions in patients with gc in the context of host immune response. to identify gc subtype-specific immune response gen ... | 2017 | 29147610 |
| spontaneous development of epstein-barr virus associated human lymphomas in a prostate cancer xenograft program. | prostate cancer research is hampered by the lack of in vivo preclinical models that accurately reflect patient tumour biology and the clinical heterogeneity of human prostate cancer. to overcome these limitations we propagated and characterised a new collection of patient-derived prostate cancer xenografts. tumour fragments from 147 unsupervised, surgical prostate samples were implanted subcutaneously into immunodeficient rag2-/-γc-/- mice within 24 hours of surgery. histologic and molecular cha ... | 2017 | 29145505 |
| burkitt lymphoma and cavernous sinus syndrome with breast uptake on 18f-fdg-pet/ct: a case report. | burkitt lymphoma (bl) is a type of non-hodgkin lymphoma that arises in the b-cells. cavernous sinus involvement is rare, especially in adults. here we report an unusual case of a 30-year-old hiv-positive woman with bl and cavernous sinus syndrome who also had intense bilateral breast uptake, related to menstrual cycle. fluorine-18 2-fluoro-2-deoxyglucose (18f-fdg) positron emission tomography/computed tomography (pet/ct) has been found to be useful in the management of bl. | 2017 | 29145302 |
| human herpesvirus 8 in perinatally hiv-infected children with interstitial lung disease. | human herpesvirus 8 (hhv-8) is associated with the pathogenesis of kaposi sarcoma and interstitial pneumonitis in adults. this study aims to evaluate association between hhv-8 and interstitial lung disease in hiv-infected children. | 2017 | 29165615 |
| a case of hodgkin lymphoma mimicking lymphomatoid granulomatosis diagnosed at autopsy. | hodgkin lymphoma and lymphomatoid granulomatosis (lyg) are entities that contain a small number of large, variably epstein-barr virus (ebv)-positive neoplastic cells scattered within background non-neoplastic mixed inflammatory infiltrate. the 2 entities can typically be distinguished histologically by the angiocentric and angiodestructive pattern of lymphomatoid granulomatosis (lyg); also, they differ in overall prognosis. herein, we report a case of hodgkin lymphoma in a 64-year-old caucasian ... | 2017 | 29165611 |
| clinicopathological and immunohistochemical study of head and neck langerhans cell histiocytosis from latin america. | langerhans cell histiocytosis (lch) is an inflammatory myeloid neoplastic proliferation with variable clinical behavior caused by the accumulation of cd1a+/cd207+ histiocytes, associated with a variable number of eosinophils, lymphocytes, plasma cells and multinucleated giant cells, most commonly observed in male children. lch is uncommon in the head and neck region, occurring as ulcerated and reddened plaques or nodules that cause destruction of adjacent soft tissues and bone. the exact etiolog ... | 2017 | 29164473 |
| tick-borne transmission of murine gammaherpesvirus 68. | herpesviruses are a large group of dna viruses infecting mainly vertebrates. murine gammaherpesvirus 68 (mhv68) is often used as a model in studies of the pathogenesis of clinically important human gammaherpesviruses such as epstein-barr virus and kaposi's sarcoma-associated herpesvirus. this rodent virus appears to be geographically widespread; however, its natural transmission cycle is unknown. following detection of mhv68 in field-collected ticks, including isolation of the virus from tick sa ... | 2017 | 29164067 |
| cd56-negative aggressive nk cell leukemia relapsing as multiple cranial nerve palsies: case report and literature review. | aggressive natural killer cell leukemia (ankl) is extremely rare and habitually manifests as a systemic disease with multiorgan failure that rapidly evolves to death. the neoplastic natural killer (nk) cells usually harbor the epstein-barr virus (ebv) with a latent viral infection pattern type ii; they often have a cytoplasmic cd3ε+ and surface cd3-, cd2+, and cd56+ immunophenotype, and they show complex genetic abnormalities affecting multiple tumor suppressor genes and oncogenes. we present a ... | 2017 | 29163992 |
| impact of chronic viral infection on t-cell dependent humoral immune response. | during the last decades, considerable efforts have been done to decipher mechanisms supported by microorganisms or viruses involved in the development, differentiation, and function of immune cells. pathogens and their associated secretome as well as the continuous inflammation observed in chronic infection are shaping both innate and adaptive immunity. secondary lymphoid organs are functional structures ensuring the mounting of adaptive immune response against microorganisms and viruses. inside ... | 2017 | 29163507 |
| therapeutic strategies against epstein-barr virus-associated cancers using proteasome inhibitors. | epstein-barr virus (ebv) is closely associated with several lymphomas (endemic burkitt lymphoma, hodgkin lymphoma and nasal nk/t-cell lymphoma) and epithelial cancers (nasopharyngeal carcinoma and gastric carcinoma). to maintain its persistence in the host cells, the virus manipulates the ubiquitin-proteasome system to regulate viral lytic reactivation, modify cell cycle checkpoints, prevent apoptosis and evade immune surveillance. in this review, we aim to provide an overview of the mechanisms ... | 2017 | 29160853 |
| [infection by the epstein-barr virus between the years 2006-2015 in the health area of santiago de compostela. relationship with age and sex]. | in spain, the age and sex to which the primary infection by ebv is produced is poorly studied. the objective of this work is to know its relation with the presence of the primary infection by ebv between the years 2006 and 2015 in our health area. | 2017 | 29160648 |
| retraction: the epstein-barr virus-encoded mir-bart22 targets map3k5 to promote host cell proliferative and invasive abilities in nasopharyngeal carcinoma. | [this retracts the article doi: 10.7150/jca.15753.]. | 2017 | 29158784 |
| immune activation and benefit from avelumab in ebv-positive gastric cancer. | response to immune checkpoint therapy can be associated with a high mutation burden, but other mechanisms are also likely to be important. we identified a patient with metastatic gastric cancer with meaningful clinical benefit from treatment with the anti-programmed death-ligand 1 (pd-l1) antibody avelumab. this tumor showed no evidence of high mutation burden or mismatch repair defect but was strongly positive for presence of epstein-barr virus (ebv) encoded rna. analysis of the cancer genome a ... | 2017 | 29155997 |
| methotrexate-associated lymphoproliferative disease with multiple pulmonary nodules in a patient with rheumatoid arthritis. | a 62-year-old woman with rheumatoid arthritis and secondary sjögren's syndrome took methotrexate (mtx) 5 mg three times a week regularly but gradually developed an intermittent fever, oral ulcers and productive cough with mucopurulent sputum for about 2 weeks. image study found multiple nodular lesions and lymphadenopathies in bilateral lungs. empirical antibiotics for 1 week failed to alleviate the fever. a transbronchial biopsy in the right fourth bronchus showed infiltration of abnormally enl ... | 2017 | 29196307 |
| characterization of the ebv-induced persistent dna damage response. | epstein-barr virus (ebv) is an oncogenic herpesvirus that is ubiquitous in the human population. early after ebv infection in vitro, primary human b cells undergo a transient period of hyper-proliferation, which results in replicative stress and dna damage, activation of the dna damage response (ddr) pathway and, ultimately, senescence. in this study, we investigated ddr-mediated senescence in early arrested ebv-infected b cells and characterized the establishment of persistent dna damage foci. ... | 2017 | 29194355 |
| clinical significance of plasma epstein-barr virus dna in pulmonary lymphoepithelioma-like carcinoma (lelc) patients. | 2017 | 29191777 | |
| pretreatment epstein-barr virus dna in whole blood is a prognostic marker in peripheral t-cell lymphoma. | because there are few studies regarding the clinical impact of circulating ebv-dna in peripheral t-cell lymphomas (ptcls), we tried to evaluate the role of ebv-dna in whole blood as a prognostic factor for ptcl. we retrospectively reviewed 110 ptcl patients with median age of 63 (20-94) years. forty-seven patients (42.7%) showed positive results for ebv-dna, and these patients also had stage iii/iv disease, elevated lactic dehydrogenase, and low albumin level (p = 0.007, p = 0.004, p = 0.002, re ... | 2017 | 29190917 |
| in response to: smit d, meyer d, maritz j, et al. "polymerase chain reaction and goldmann-witmer coefficient to examine the role of epstein-barr virus in uveitis". | 2017 | 29190161 | |
| epstein-barr virus clonality and plasmacytosis in a patient with atypical angioimmunoblastic t cell lymphoma. | 2017 | 29189897 | |
| ebv+ hhv-8+ multicentric castleman disease with plasmablastic aggregates in an hiv+ man: an evolving clinicopathologic entity. | we report a case of ebv+ and hhv-8+ multicentric castleman disease with plasmablastic aggregates in an hiv-positive individual. a 41-year-old man presented in early 2015 with fevers, sweats, weight loss, intractable itching, and on subsequent testing was found to be hiv positive. investigations showed cervical lymphadenopathy and splenomegaly. he was treated for hiv and his symptoms resolved. his symptoms recurred in january 2016, and a provisional diagnosis of multicentric castleman disease was ... | 2017 | 29198143 |
| bacterial artificial chromosomes establish replication timing and sub-nuclear compartment de novo as extra-chromosomal vectors. | the role of dna sequence in determining replication timing (rt) and chromatin higher order organization remains elusive. to address this question, we have developed an extra-chromosomal replication system (e-bacs) consisting of ∼200 kb human bacterial artificial chromosomes (bacs) modified with epstein-barr virus (ebv) stable segregation elements. e-bacs were stably maintained as autonomous mini-chromosomes in ebna1-expressing hela or human induced pluripotent stem cells (hipscs) and established ... | 2017 | 29294101 |