Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| recruitment of minority adolescents and young adults into randomised clinical trials: testing the design of the technology enhanced community health nursing (tech-n) pelvic inflammatory disease trial. | pelvic inflammatory disease (pid) disproportionately affects adolescent and young adult (aya) women and can negatively influence reproductive health trajectories. few randomized controlled trials (rcts) have focused on strategies to improve outpatient adherence or to reduce reproductive morbidity in this population. this paper describes the research methods and preliminary effectiveness of recruitment, retention, and intervention strategies employed in a novel rct designed to test a technology-e ... | 2016 | 27617108 |
| loop-mediated isothermal amplification targeting actin dna of trichomonas vaginalis. | trichomoniasis caused by trichomonas vaginalis is a common sexually transmitted disease. its association with several health problems, including preterm birth, pelvic inflammatory disease, cervical cancer, and transmission of human immunodeficiency virus, emphasizes the importance of improved access to early and accurate detection of t. vaginalis. in this study, a rapid and efficient loop-mediated isothermal amplification-based method for the detection of t. vaginalis was developed and validated ... | 2016 | 27417089 |
| a novel point-of-care testing strategy for sexually transmitted infections among pregnant women in high-burden settings: results of a feasibility study in papua new guinea. | sexually transmitted and genital infections in pregnancy are associated with an increased risk of adverse maternal and neonatal health outcomes. high prevalences of sexually transmitted infections have been identified among antenatal attenders in papua new guinea. papua new guinea has amongst the highest neonatal mortality rates worldwide, with preterm birth and low birth weight major contributors to neonatal mortality. the overall aim of our study was to determine if a novel point-of-care testi ... | 2016 | 27268218 |
| a systematic review of point of care testing for chlamydia trachomatis, neisseria gonorrhoeae, and trichomonas vaginalis. | objectives. systematic review of point of care (poc) diagnostic tests for sexually transmitted infections: chlamydia trachomatis (ct), neisseria gonorrhoeae (ng), and trichomonas vaginalis (tv). methods. literature search on pubmed for articles from january 2010 to august 2015, including original research in english on poc diagnostics for sexually transmitted ct, ng, and/or tv. results. we identified 33 publications with original research on poc diagnostics for ct, ng, and/or tv. thirteen articl ... | 2016 | 27313440 |
| comparative analysis of syndromic and pcr-based diagnostic assay reveals misdiagnosis/ overtreatment for trichomoniasis based on subjective judgment in symptomatic patients. | trichomoniasis, a sexually transmitted disease (std), is caused by trichomonas vaginalis in both men and women. screening of trichomoniasis is problematic in resource challenged settings as currently available, inexpensive diagnostic methods are of low sensitivity and/or specificity. in india, national aids control organization (naco) recommended syndromic case management (scm) for treatment. the objective of the present study was to compare the utility of the naco-nacp iii algorithms for sti/rt ... | 2016 | 27146362 |
| prevalence and risk factors of three curable sexually transmitted infections among women in nairobi, kenya. | sexually transmitted infections (stis) are a major public health problem, especially in developing countries. the complications of untreated stis in the female genital tract and their role in adverse pregnancy and perinatal outcomes have been well documented. the prevalence of stis in kenya among women in the general population has not been extensively studied and there is a lack of guidelines for screening of non-pregnant women. knowledge of the prevalence of curable stis among this population ... | 2016 | 27026347 |
| acceptability and feasibility of sexually transmitted infection testing and treatment among pregnant women in gaborone, botswana, 2015. | chlamydia trachomatis (ct), neisseria gonorrhoeae (ng), and trichomonas vaginalis (tv) are curable sexually transmitted infections (stis) that can cause adverse maternal and birth outcomes. most countries do not conduct routine testing during antenatal care. we present data on the acceptability and feasibility of testing and treating pregnant women for stis in an antenatal clinic in gaborone, botswana. | 2016 | 27119076 |
| prevalence of trichomonas vaginalis in women visiting 2 obstetrics and gynecology clinics in daegu, south korea. | this study explored epidemiological trends in trichomoniasis in daegu, south korea. wet mount microscopy, pcr, and multiplex pcr were used to test for trichomonas vaginalis in vaginal swab samples obtained from 621 women visiting 2 clinics in daegu. of the 621 women tested, microscopy detected t. vaginalis in 4 (0.6%) patients, pcr detected t. vaginalis in 19 (3.0%) patients, and multiplex pcr detected t. vaginalis in 12 (1.9%) patients. testing via pcr demonstrated high sensitivity and high neg ... | 2016 | 26951983 |
| suboptimal trichomonas vaginalis antigen test performance in a low-prevalence sexually transmitted infection community. | 2016 | 26659216 | |
| clinical laboratory assessment of mycoplasma genitalium transcription-mediated amplification using primary female urogenital specimens. | following analysis of primary cervix, vagina, and first-void female urine specimens for chlamydia trachomatis, neisseria gonorrhoeae, and trichomonas vaginalis via commercial transcription-mediated amplification (tma), residual material was subjected to mycoplasma genitalium research-use-only tma. representation within a 2,478-specimen retrospective study set was established by comparison to a 6-month audit of clinical c. trachomatis tma (12,999 specimens) on the basis of the c. trachomatis dete ... | 2016 | 26659209 |
| prevalence of reproductive tract infections and the predictive value of girls' symptom-based reporting: findings from a cross-sectional survey in rural western kenya. | reproductive tract infections (rtis), including sexually acquired, among adolescent girls is a public health concern, but few studies have measured prevalence in low-middle-income countries. the objective of this study was to examine prevalence in rural schoolgirls in kenya against their reported symptoms. | 2016 | 26819339 |
| alcohol use problems and sexual risk among young adult african american mothers. | studies have documented high levels of alcohol use and sexual risk among young mothers. we examined parenting satisfaction and self-efficacy in relation to alcohol use problems and sexual risk among 346 young african american women enrolled in an hiv prevention trial, 41 % (n = 141) of whom were mothers. among mothers, greater parenting satisfaction was associated with a reduced likelihood of problematic alcohol use, having multiple sex partners, and testing positive for trichomonas vaginalis. r ... | 2016 | 26499334 |
| microbiological characteristics of chlamydia trachomatis and neisseria gonorrhoeae infections in south african women. | we analyzed data of 263 women with at least one genital or anorectal sexually transmitted infection from a cross-sectional study conducted in rural south africa. we provide new insights concerning the concurrence of chlamydia trachomatis, neisseria gonorrhoeae, mycoplasma genitalium, and trichomonas vaginalis infections as well as the characteristics of bacterial loads. | 2015 | 26511740 |
| clinical and laboratory testing for trichomonas vaginalis infection. | trichomonas vaginalis infection is highly prevalent in the united states and worldwide. traditional clinical diagnostic methods fail to identify more than half of these infections that, if left untreated, can result in adverse pregnancy outcomes and an exacerbated risk of both acquisition and transmission of hiv. women bear a disproportionate amount of the burden of these infections, and testing among populations at risk for this disease should be provided. molecular technologies have expanded o ... | 2015 | 26491181 |
| prevalence of 7 sexually transmitted organisms by multiplex real-time pcr in fallopian tube specimens collected from saudi women with and without ectopic pregnancy. | ectopic pregnancy (ep) is associated with maternal morbidity and occasionally mortality during the first trimester. a history of sexually transmitted infection (sti) and pelvic inflammatory disease have been implicated as major risk factors for ep. our aim was to measure the prevalence of chlamydia trachomatis (ct), neisseria gonorrhoeae, mycoplasma genitalium (mg), ureaplasma parvum/urealyticum, gardnerella vaginalis, trichomonas vaginalis and herpes simplex virus (hsv)-1&2 in fallopian tubes c ... | 2015 | 26666587 |
| patient-delivered partner treatment for chlamydia, gonorrhea, and trichomonas infection among pregnant and postpartum women in kenya. | patient-delivered partner treatment (pdpt) for sexually transmitted infections (stis) increases rates of partner treatment and decreases reinfection, but has not been evaluated during pregnancy. | 2015 | 26462189 |
| relationship between female genital tract infections, mucosal interleukin-17 production and local t helper type 17 cells. | t helper type 17 (th17) cells play an important role in immunity to fungal and bacterial pathogens, although their role in the female genital tract, where exposure to these pathogens is common, is not well understood. we investigated the relationship between female genital tract infections, cervicovaginal interleukin-17 (il-17) concentrations and th17 cell frequencies. forty-two cytokines were measured in cervicovaginal lavages from hiv-uninfected and hiv-infected women. frequencies of th17 cell ... | 2015 | 26302175 |
| the contribution of cervicovaginal infections to the immunomodulatory effects of hormonal contraception. | particular types of hormonal contraceptives (hcs) and genital tract infections have been independently associated with risk of hiv-1 acquisition. we examined whether immunity in women using injectable depot medroxyprogesterone acetate (dmpa), combined oral contraceptives (coc), or no hcs differs by the presence of cervicovaginal infections. immune mediators were quantified in cervical swabs from 832 hiv-uninfected reproductive-age ugandans and zimbabweans. bacterial infections and hiv were diagn ... | 2015 | 26330510 |
| use of a risk quiz to predict infection for sexually transmitted infections: a retrospective analysis of acceptability and positivity. | individuals who are sexually active may want to make a decision as to whether they are at risk for having a sexually transmitted infection (sti) such as chlamydia trachomatis, neisseria gonorrhoeae and trichomonas vaginalis. our goal was to develop and evaluate a simple self-taken sexual risk quiz for participants, ordering an online sti self-collection test kit to determine whether the score predicted infection status. | 2015 | 26285773 |
| trichomonas vaginalis: a review of epidemiologic, clinical and treatment issues. | trichomonas vaginalis (tv) is likely the most common non-viral sexually transmitted infection (sti) in the world. it is as an important source of reproductive morbidity, a facilitator of hiv transmission and acquisition, and thus it is an important public health problem. despite its importance in human reproductive health and hiv transmission, it is not a reportable disease and surveillance is not generally done. this is problematic since most persons infected with tv are asymptomatic. metronida ... | 2015 | 26242185 |
| abuse impedes prevention: the intersection of intimate partner violence and hiv/sti risk among young african american women. | intimate partner violence (ipv) is associated with risky sexual behavior and stis among diverse groups of women. ipv was examined as a moderator of efficacy for an hiv/sti intervention. 848 african american women, 18-29, were randomly assigned to an hiv/sti intervention or control condition. participants completed measures on sociodemographics, ipv, risky sexual behavior and received sti testing. ipv predicted inconsistent condom use and a risky sexual partner over 12-month follow-up. a signific ... | 2015 | 25399033 |
| management of non-gonococcal urethritis. | non-gonococcal urethritis (ngu), or inflammation of the urethra, is the most common treatable sexually transmitted syndrome in men, with approximately 20-50 % of cases being due to infection with chlamydia trachomatis and 10-30 % mycoplasma genitalium. other causes are ureaplasma urealyticum, trichomonas vaginalis, anaerobes, herpes simplex virus (hsv) and adenovirus. up to half of the cases are non-specific. urethritis is characterized by discharge, dysuria and/or urethral discomfort but may be ... | 2015 | 26220178 |
| rna biosignatures in adolescent patients in a pediatric emergency department with pelvic inflammatory disease. | adolescents are at high risk for pelvic inflammatory disease (pid). because accurate diagnosis of pid is difficult, and complications of untreated pid are significant, novel methods to improve diagnosis are essential. | 2015 | 26125533 |
| overdiagnosis of urinary tract infection and underdiagnosis of sexually transmitted infection in adult women presenting to an emergency department. | urinary tract infections (utis) and sexually transmitted infections (stis) are commonly diagnosed in emergency departments (eds). distinguishing between these syndromes can be challenging because of overlapping symptomatology and because both are associated with abnormalities on urinalysis (ua). we conducted a 2-month observational cohort study to determine the accuracy of clinical diagnoses of uti and sti in adult women presenting with genitourinary (gu) symptoms or diagnosed with gu infections ... | 2015 | 26063863 |
| epidemiology and treatment of trichomoniasis. | trichomonas vaginalis is the most common nonviral sexually transmitted infection (sti) in the world. it was once thought to be a nuisance sti, but it is now being recognized as an important source of reproductive morbidity and a facilitator of hiv transmission and acquisition, and thus it is an important public health problem. the prevalence of t. vaginalis varies greatly by geography and risk group, but is more common among persons of african descent and appears to increase with age, though thi ... | 2015 | 25925796 |
| evaluating hiv prevention programs: herpes simplex virus type 2 antibodies as biomarker for sexual risk behavior in young adults in resource-poor countries. | measuring effectiveness of hiv prevention interventions is challenged by bias when using self-reported knowledge, attitude or behavior change. hiv incidence is an objective marker to measure effectiveness of hiv prevention interventions, however, because new infection rates are relatively low, prevention studies require large sample sizes. herpes simplex virus type 2 (hsv-2) is similarly transmitted and more prevalent and could thus serve as a proxy marker for sexual risk behavior and therefore ... | 2015 | 26010772 |
| sexually transmitted infections, benign prostatic hyperplasia and lower urinary tract symptom-related outcomes: results from the prostate, lung, colorectal and ovarian cancer screening trial. | to examine whether a history of sexually transmitted infections (stis) or positive sti serology is associated with prevalent and incident benign prostatic hyperplasia (bph)/lower urinary tract symptoms (luts)-related outcomes in the prostate, lung, colorectal and ovarian cancer screening trial. | 2015 | 25601300 |
| a sexually transmitted infection screening algorithm based on semiparametric regression models. | sexually transmitted infections (stis) with chlamydia trachomatis, neisseria gonorrhoeae, and trichomonas vaginalis are among the most common infectious diseases in the united states, disproportionately affecting young women. because a significant portion of the infections present no symptoms, infection control relies primarily on disease screening. however, universal sti screening in a large population can be expensive. in this paper, we propose a semiparametric model-based screening algorithm. ... | 2015 | 25900920 |
| prevalence of sexually transmitted infections including hiv in street-connected adolescents in western kenya. | the objectives of this study were to characterise the sexual health of street-connected adolescents in eldoret, kenya, analyse gender disparity of risks, estimate the prevalence of sexually transmitted infections (stis), and identify factors associated with stis. | 2015 | 25714102 |
| prevalence of mycoplasma genitalium and mycoplasma hominis in urogenital tract of brazilian women. | the role of mycoplasma hominis and m. genitalium in urogenital tract infections remains unknown. furthermore these mollicutes present a complex relationship with the host immune response. the role of inflammatory cytokines in infections also makes them good candidates to investigate bacterial vaginosis and mycoplasma genital infections. therefore, the aim of this study was to detect the above-mentioned mollicutes by quantitative polymerase chain reaction (qpcr) methodologies in vaginal swabs and ... | 2015 | 25886914 |
| prevalence of 3 sexually transmitted infections in a pediatric emergency department. | this study aimed to determine the prevalence of chlamydia trachomatis, neisseria gonorrheae, and trichomonas vaginalis and to describe factors associated with sexually transmitted infection (sti) in a pediatric emergency department (ed). | 2015 | 25654676 |
| polymerase chain reaction as a diagnostic tool for six sexually transmitted infections - preliminary results. | sexually transmitted infections are a very frequent and under-diagnosed cause of illness worldwide. a high number of detection methods and a large range of specimens in which sexually transmitted infections can be determined are available at the moment. polymerase chain reaction performed on first void urine offers the advantage of being non-invasive, self-collectable and has high sensitivity and specificity. we looked to determine the frequency of chlamydia trachomatis, neisseria gonorrhoeae, t ... | 2015 | 26528045 |
| characterization of specific rapd markers of virulence in trichomonas vaginalis isolates. | as for human trichomoniasis the host-parasite relationship is very complex, and the broad ranges of clinical symptoms are unlikely be attributable to a single pathogenic mechanism. specific random amplified polymorphic dna (rapd) markers of 490 bp, 720 bp and 460 bp using the primers tv-5, opa-6 and opa-11, respectively, were reported. this was the first description of possible genetic virulence markers of the infection by t. vaginalis. the aim of this study was to characterize the specific rapd ... | 2015 | 26622300 |
| genital infections and risk of premature rupture of membranes in mulago hospital, uganda: a case control study. | inflammatory mediators that weaken and cause membrane rupture are released during the course of genital infections among pregnant women. we set out to determine the association of common genital infections (trichomonas vaginalis, syphilis, neisseria gonorrhea, chlamydia trachomatis, group b streptococcus, bacterial vaginosis, herpes simplex virus type 2 and candidiasis) and premature rupture of membranes in mulago hospital, uganda. | 2015 | 26475265 |
| characteristics of women enrolled into a randomized clinical trial of dapivirine vaginal ring for hiv-1 prevention. | women in sub-saharan africa are a priority population for evaluation of new biomedical hiv-1 prevention strategies. antiretroviral pre-exposure prophylaxis is a promising prevention approach; however, clinical trials among young women using daily or coitally-dependent products have found low adherence. antiretroviral-containing vaginal microbicide rings, which release medication over a month or longer, may reduce these adherence challenges. | 2015 | 26061040 |
| changes in the contribution of genital tract infections to hiv acquisition among kenyan high-risk women from 1993 to 2012. | the objective of this study was to understand temporal trends in the contribution of different genital tract infections to hiv incidence over 20 years of follow-up in a cohort of high-risk women. | 2015 | 26125141 |
| rho gtpases as pathogen targets: focus on curable sexually transmitted infections. | pathogens have evolved highly specialized mechanisms to infect hosts. several microorganisms modulate the eukaryotic cell surface to facilitate their engulfment. once internalized, they hijack the molecular machinery of the infected cell for their own benefit. at different stages of phagocytosis, particularly during invasion, certain pathogens manipulate pathways governed by small gtpases. in this review, we focus on the role of rho proteins on curable, sexually transmitted infections caused by ... | 2015 | 26023809 |
| female reproductive hormones and biomarkers of oxidative stress in genital chlamydia infection in tubal factor infertility. | genital chlamydia infection (gci) and the associated pathologies have been implicated in tubal infertility. though the actual pathologic mechanisms are still uncertain, oxidative stress and other factors have been implicated. the purpose of the study was to determine the possible contribution of female reproductive hormones and biomarkers of oxidative stress in genital chlamydial infection to tubal occlusion. | 2015 | 25927024 |
| multipurpose prevention technologies: the future of hiv and sti protection. | every day, more than 1 million people are newly infected with sexually transmitted infections (stis) that can lead to morbidity, mortality, and an increased risk of human immunodeficiency virus (hiv) acquisition. existing prevention and management strategies, including behavior change, condom promotion, and therapy have not reduced the global incidence and prevalence, pointing to the need for novel innovative strategies. this review summarizes important issues raised during a satellite session a ... | 2015 | 25759332 |
| sexually transmitted pathogens, depression, and other manifestations associated with premenstrual syndrome. | this study investigated whether sexually transmitted infections and lifestyle variables are associated with premenstrual syndrome (pms) as well as particular manifestations commonly associated with pms. data were gathered from medical records of 500 regularly cycling women. the following infectious agents were investigated: human papillomavirus, chlamydia trachomatis, neisseria gonorrheae, gardnerella vaginalis, candida albicans, and trichomonas vaginalis. bivariate tests and multivariate logist ... | 2015 | 26272230 |
| value of bacterial culture of vaginal swabs in diagnosis of vaginal infections. | vaginal and cervical swab culture is still very common procedure in our country's everyday practice whereas simple and rapid diagnostic methods have been very rarely used. the aim of this study was to show that the employment of simple and rapid diagnostic tools [vaginal fluid wet mount microscopy (vfwmm), vaginal ph and potassium hydroxide (koh) test] offers better assessment of vaginal environment than standard microbiologic culture commonly used in serbia. | 2015 | 26226725 |
| performance evaluation of a dna chip assay in the identification of major genitourinary pathogens. | to prevent the recurrence of genitourinary infections and to reduce the risks of their complications, accurate and rapid diagnosis are required. stdetect® chip is a dna chip which allows for the simultaneous detection of 13 major genitourinary pathogens in a single vaginal swab or urine specimen. we evaluated the analytical performance of the stdetect® chip for detecting target pathogens that commonly cause genitourinary infections. | 2015 | 25533217 |
| modulatory effect of iron chelators on adenosine deaminase activity and gene expression in trichomonas vaginalis. | trichomonas vaginalis is a flagellate protozoan that parasitises the urogenital human tract and causes trichomoniasis. during the infection, the acquisition of nutrients, such as iron and purine and pyrimidine nucleosides, is essential for the survival of the parasite. the enzymes for purinergic signalling, including adenosine deaminase (ada), which degrades adenosine to inosine, have been characterised in t. vaginalis. in the evaluation of the ada profile in different t. vaginalis isolates trea ... | 2015 | 26517498 |
| utility of microbiological profile of symptomatic vaginal discharge in rural women of reproductive age group. | symptomatic vaginal discharge is the most frequent symptom in women of reproductive age group. owing to social stigma majority of affected women hesitate to seek medical consultation. therefore the actual incidence of vaginal discharge is much more than what is reported. the aim of the study is to determine the microbiological profile of symptomatic vaginal discharge in rural area and its utility in the management of genital tract infection. | 2015 | 25954668 |
| anaerobic respiration: in vitro efficacy of nitazoxanide against mitochondriate acanthamoeba castellanii of the t4 genotype. | acanthamoeba is an opportunistic protist pathogen that is responsible for serious human and animal infection. being one of the most frequently isolated protists from the environment, it is likely that it readily encounters microaerophilic environments. for respiration under anaerobic or low oxygen conditions in several amitochondriate protists, decarboxylation of pyruvate is catalyzed by pyruvate ferredoxin oxidoreductase instead of pyruvate dehydrogenase. in support, nitazoxanide, an inhibitor ... | 2015 | 26297676 |
| mucosal blood group antigen expression profiles and hiv infections: a study among female sex workers in kenya. | the abo blood group antigens are carbohydrate moieties expressed on human red blood cells however; these antigens can also be expressed on some other cells particularly the surface of epithelial cells and may be found in mucosal secretions. in many human populations 80% secrete abo antigens (termed 'secretors') while 20% do not (termed 'non-secretors'). furthermore, there are disease conditions that are associated with secretor status. | 2015 | 26186209 |
| genome mining offers a new starting point for parasitology research. | parasites including helminthes, protozoa, and medical arthropod vectors are a major cause of global infectious diseases, affecting one-sixth of the world's population, which are responsible for enormous levels of morbidity and mortality important and remain impediments to economic development especially in tropical countries. prevalent drug resistance, lack of highly effective and practical vaccines, as well as specific and sensitive diagnostic markers are proving to be challenging problems in p ... | 2015 | 25563615 |
| analytical performance of multiplex real-time pcr for six sexually transmitted pathogens. | most organisms that cause sexual transmitted diseases (stds) are fastidious pathogens that are difficult to detect with conventional microbiological methods and the proportions of multiple infections were noted up to 39.3% among the sti-positive subjects. however, only a few multiplex pcr and multiplex real-time pcr tests that can screen more than six microorganisms that cause stds have been assessed. | 2015 | 26732001 |
| a mixed methods approach to assess the likelihood of testing for sti using self-collected samples among behaviourally bisexual women. | behaviourally bisexual women (women who have sex with women and men (wswm)) are more likely to report a history of sexually transmitted infections (sti) than women who have sex exclusively with men or exclusively with women. barriers to care may prohibit wswm from seeking sti testing. the present study investigated participant willingness to self-collect oral, vaginal and anal samples for sti testing. | 2015 | 25637328 |
| a multiplex pcr assay for the simultaneous detection of chlamydia trachomatis, neisseria gonorrhoeae, and trichomonas vaginalis. | for developing countries, sexually transmitted infections (stis) and their complications are ranked in the top 5 disease categories for which adults seek medical treatment. chlamydia trachomatis (ct), neisseria gonorrhoeae (ng), and trichomonas vaginalis (tv) are the three most common stis worldwide, with tv accounting for over half of the cases. in developing countries, traditional methods for diagnosing stis are laborious, often not very sensitive, and have a long turnaround time with most rec ... | 2015 | 25595915 |
| detection of mycoplasma genitalium from male primary urine specimens: an epidemiologic dichotomy with trichomonas vaginalis. | a total of 2750 male urines subjected to a transcription-mediated amplification (tma)-based mycoplasma genitalium assay yielded 188 positive results (6.84%). this rate was similar to chlamydia trachomatis (6.87%; p = 0.96) and greater than neisseria gonorrhoeae (4.0%) and trichomonas vaginalis (2.3%; p < 0.0002). mean age of m. genitalium-infected males (30.8) was similar to n. gonorrhoeae (p = 0.78) but less than t. vaginalis (mean, 41.6; p < 0.0001). a total of 266 sti clinic encounters had at ... | 2015 | 25934156 |
| distribution of human papillomavirus (hpv) genotypes and bacterial vaginosis presence in cervical samples from paraguayan indigenous. | to determine the frequency of human papillomavirus (hpv) types and to assess bacterial vaginosis (bv) possible associations with cervical infections in indigenous paraguayan women of the department of presidente hayes. | 2015 | 26283550 |
| prevalence and risk factors for chlamydia trachomatis, neisseria gonorrhoeae and trichomonas vaginalis infection in pregnant women in papua new guinea. | to determine the prevalence of, and risk factors associated with, chlamydia trachomatis, neisseria gonorrhoeae and trichomonas vaginalis infection in pregnant women in madang, papua new guinea (png). | 2015 | 25313204 |
| prevalence of trichomonas vaginalis, chlamydia trachomatis, neisseria gonorrhoeae and human papillomavirus in a sexual health clinic setting in urban sri lanka. | the prevalences of trichomonas vaginalis, chlamydia trachomatis, neisseria gonorrhoeae, and human papillomavirus (hpv) in sri lanka are not well reported; the objective of this study is to describe the prevalences of these four sexually transmitted infections among attendees of sexual health clinic in an urban setting. vaginal swabs were collected from consenting women attending a sexual health clinic and tested for the presence of the above sexually transmitted infections using nucleic acid amp ... | 2015 | 25258396 |
| epidemiology of sexually transmitted infections in rural haitian men. | the study attempts to determine the prevalence of organisms associated with urethritis in men in rural southwestern haiti and to determine the association with demographic, clinical and laboratory variables. a standardised verbal interview was conducted; genital examinations were done; urethral swabs were collected for nucleic acid amplification testing, and first void urine was obtained for urinalysis. the mean participant age was 54; 88.8% lived in a rural area. swabs were positive for trichom ... | 2015 | 25228665 |
| comparison of cervico-vaginal colonization among sexually active women by intrauterine device use. | in this study we aimed to evaluate the effect of intrauterine devices (iuds) on cervico-vaginal colonization. | 2015 | 26409733 |
| evaluation of the new amplisens multiplex real-time pcr assay for simultaneous detection of neisseria gonorrhoeae, chlamydia trachomatis, mycoplasma genitalium, and trichomonas vaginalis. | in this study, we performed an evaluation of the new ce-marked multiplex real-time amplisens n.gonorrhoeae/c.trachomatis/m.genitalium/t.vaginalis-multiprime-frt pcr assay compared to aptima tests, i.e., aptima combo 2 assay, aptima trichomonas vaginalis assay (fda-approved), and two different aptima mycoplasma genitalium assays (research use only; one of them only used for discrepancy analysis). vaginal swabs (n = 209) and first-void urine (fvu) specimens from females (n = 498) and males (n = 55 ... | 2015 | 26299582 |
| prevalence of vulvovaginitis and relation to physical findings in girls assessed for suspected child sexual abuse. | the presence of sexually transmitted infections (stis) in patients with suspected sexual abuse is uncommon in the field of pediatrics. | 2015 | 26294142 |
| diagnosis and treatment of bacterial prostatitis. | prostate inflammation is a common syndrome, especially in men under 50. it usually presents with voiding symptoms and pain in the genitourinary area, and sometimes as sexual dysfunction. based on clinical and laboratory characteristics, prostatitis is classified as acute bacterial prostatitis, chronic bacterial prostatitis, chronic inflammatory and non-inflammatory prostatitis or chronic pelvic pain syndrome, and asymptomatic inflammatory prostatitis. bacterial prostatitis is most often caused b ... | 2015 | 26086164 |
| the role of chlamydia trachomatis in high-risk human papillomavirus persistence among female sex workers in nairobi, kenya. | little is known about risk factors for persistent high-risk human papillomavirus (hrhpv) infection in low-income settings, and prior research has not quantified the relative duration of hrhpv infections stratified by risk factors. we compared the duration of hrhpv infection among female sex workers (fsws) by exposure to sexually transmitted infections (stis), using a highly sensitive biomarker assay. | 2015 | 25970306 |
| sexual assault and sexually transmitted infections in adults, adolescents, and children. | survivors of sexual assault are at risk for acquiring sexually transmitted infections (stis). we conducted literature reviews and invited experts to assist in updating the sexual assault section for the 2015 centers for disease control and prevention sexually transmitted diseases (std) treatment guidelines. new recommendations for sti management among adult and adolescent sexual assault survivors include use of nucleic acid amplification tests (naats) for detection of trichomonas vaginalis by va ... | 2015 | 26602623 |
| advances in the understanding and treatment of male urethritis. | neisseria gonorrhoeae and chlamydia trachomatis are well-documented urethral pathogens, and the literature supporting mycoplasma genitalium as an etiology of urethritis is growing. trichomonas vaginalis and viral pathogens (herpes simplex virus types 1 and 2 and adenovirus) can cause urethritis, particularly in specific subpopulations. new data are emerging regarding the potential role of bacterial vaginosis-associated bacteria in urethritis, although results are inconsistent regarding the patho ... | 2015 | 26602615 |
| high prevalence and incidence of asymptomatic sexually transmitted infections during pregnancy and postdelivery in kwazulu natal, south africa. | we report the prevalence and incidence of 3 treatable sexually transmitted pathogens (neiserria gonorrhoeae, chlamydia trachomatis, and trichomonas vaginalis) in women who were hiv infected or at high risk for hiv infection, in pregnancy and postpartum, respectively. | 2015 | 25504300 |
| incidence of curable sexually transmissible infections among adolescents and young adults in remote australian aboriginal communities: analysis of longitudinal clinical service data. | to undertake the first comprehensive analysis of the incidence of three curable sexually transmissible infections (stis) within remote australian aboriginal populations and provide a basis for developing new control initiatives. | 2015 | 25371420 |
| coinfection with chlamydia trachomatis, neisseria gonorrhoeae and trichomonas vaginalis: a cross-sectional analysis of positivity and risk factors in remote australian aboriginal communities. | to determine the co-occurrence and epidemiological relationships of chlamydia trachomatis (ct), neisseria gonorrhoeae (ng) and trichomonas vaginalis (tv) in a high-prevalence setting in australia. | 2015 | 25352691 |
| prevalence and factors associated with sexually transmitted infections among hiv positive women opting for intrauterine contraception. | women living with hiv/aids (wlha) are a high risk group for sexually transmitted infections (stis). however, the majority of women with stis are asymptomatic. data on prevalence of stis among wlha in uganda are limited. the objective of the study was to determine prevalence and factors associated with stis among wlha opting for intrauterine contraceptive device (iud). | 2015 | 25859659 |
| opportunities and pitfalls of molecular testing for detecting sexually transmitted pathogens. | in the last 20 years, nucleic acid amplification tests (naats) have gradually replaced traditional methods for the detection of sexually transmitted infections. naat technology comes with some considerable benefits for diagnosis, including increased sensitivity, rapid result turnaround and suitability for high throughput screening of asymptomatic individuals using more-readily available specimens. however, the transition to naat has not come without its problems. false-negative and false-positiv ... | 2015 | 25714587 |
| prevalence of trichomonas vaginalis, mycoplasma genitalium and ureaplasma urealyticum in men with urethritis attending an urban sexual health clinic. | we conducted a study to determine the prevalence of trichomonas vaginalis (tv), mycoplasma genitalium (mg) and ureaplasma urealyticum (uu) in men with urethritis, attending an urban sexual health clinic, in order to inform screening and treatment policies. men attending an urban sexual health clinic between june 2011 and january 2012 were evaluated. urine samples were collected from men with urethritis and tested for chlamydia trachomatis (ct), neisseria gonorrhoeae (gc) and tv using transcripti ... | 2015 | 24925897 |
| n-terminal presequence-independent import of phosphofructokinase into hydrogenosomes of trichomonas vaginalis. | mitochondrial evolution entailed the origin of protein import machinery that allows nuclear-encoded proteins to be targeted to the organelle, as well as the origin of cleavable n-terminal targeting sequences (nts) that allow efficient sorting and import of matrix proteins. in hydrogenosomes and mitosomes, reduced forms of mitochondria with reduced proteomes, nts-independent targeting of matrix proteins is known. here, we studied the cellular localization of two glycolytic enzymes in the anaerobi ... | 2015 | 26475173 |
| identification of cytolytic vaginosis versus vulvovaginal candidiasis. | this study aimed to observe the morphological characteristic of vaginal discharge in patients with cytolytic vaginosis (cv) under the microscope and to identify it in patients with cv and in patients with vulvovaginal candidiasis (vvc). | 2015 | 25279977 |
| synthesis of nitro(benzo)thiazole acetamides and in vitro antiprotozoal effect against amitochondriate parasites giardia intestinalis and trichomonas vaginalis. | we synthesized four 5-nitrothiazole (1-4) and four 6-nitrobenzothiazole acetamides (5-8) using an easy two step synthetic route. all compounds were tested in vitro against amitochondriate parasites giardia intestinalis and trichomonas vaginalis, showing excellent antiprotozoal effects. ic₅₀'s of the most potent compounds range from nanomolar to low micromolar order, being more active than their drugs of choice. compound 1 (ic₅₀=122 nm), was 44-times more active than metronidazole, and 10-fold mo ... | 2015 | 25801157 |
| effect of recombinant prophenin 2 on the integrity and viability of trichomonas vaginalis. | trichomonas vaginalis is the causal agent of trichomoniasis, which is associated with preterm child delivery, low birth weight, and an increased risk of infection by human papilloma virus and human immunodeficiency virus following exposure. several reports have established increasing numbers of trichomoniasis cases resistant to metronidazole, the agent used for treatment, and it is therefore important to identify new therapeutic alternatives. previously, our group reported the effect of tritrpti ... | 2015 | 25815316 |
| trichomonas vaginalis infection induces vaginal cd4+ t-cell infiltration in a mouse model: a vaccine strategy to reduce vaginal infection and hiv transmission. | complications related to the diagnosis and treatment of trichomonas vaginalis infection, as well as the association between t. vaginalis infection and increased transmission of and susceptibility to human immunodeficiency virus, highlight the need for alternative interventions. we tested a human-safe, aluminum hydroxide-adjuvanted whole-cell t. vaginalis vaccine for efficacy in a balb/c mouse model of vaginal infection. | 2015 | 25616405 |
| a review of evidence-based care of symptomatic trichomoniasis and asymptomatic trichomonas vaginalis infections. | trichomonas vaginalis is the most prevalent nonviral sexually transmitted infection, affecting an estimated 3.7 million women and men in the united states. health disparities are prominent in the epidemiology of this infection, which affects 11% of women aged ≥40 years and a disproportionately high percentage of black women. particularly high prevalences have been identified among sexually transmitted disease (std) clinic patients and incarcerated individuals. this article reviews and updates sc ... | 2015 | 26602621 |
| the efficacy of 2-nitrovinylfuran derivatives against leishmania in vitro and in vivo. | despite recent advances in the treatment of some forms of leishmaniasis, the available drugs are still far from ideal due to inefficacy, parasite resistance, toxicity and cost. the wide-spectrum antimicrobial activity of 2-nitrovinylfuran compounds has been described, as has their activity against trichomonas vaginalis and other protozoa. thus, the aim of this study was to test the antileishmanial activities of six 2-nitrovinylfurans in vitro and in a murine model of leishmaniasis. minimum paras ... | 2015 | 25946239 |
| the efficacy of 2-nitrovinylfuran derivatives against leishmania in vitro and in vivo. | despite recent advances in the treatment of some forms of leishmaniasis, the available drugs are still far from ideal due to inefficacy, parasite resistance, toxicity and cost. the wide-spectrum antimicrobial activity of 2-nitrovinylfuran compounds has been described, as has their activity against trichomonas vaginalis and other protozoa. thus, the aim of this study was to test the antileishmanial activities of six 2-nitrovinylfurans in vitro and in a murine model of leishmaniasis. minimum paras ... | 2015 | 25807467 |
| high rates of double-stranded rna viruses and mycoplasma hominis in trichomonas vaginalis clinical isolates in south brazil. | trichomonas vaginalis is the etiological agent of trichomoniasis, the most common non-viral sexually transmitted disease (std) in world, with 276.4 million new cases each year. t. vaginalis can be naturally infected with mycoplasma hominis and trichomonasvirus species. this study aimed to evaluate the prevalence of t. vaginalis infected with four distinct t. vaginalis viruses (tvvs) and m. hominis among isolates from patients in porto alegre city, south brazil. an additional goal of this study w ... | 2015 | 26160539 |
| polyamine quinoline rhodium complexes: synthesis and pharmacological evaluation as antiparasitic agents against plasmodium falciparum and trichomonas vaginalis. | a series of mono- and bis-salicylaldimine ligands and their corresponding rh(i) complexes were prepared. the compounds were characterised using standard spectroscopic techniques including nmr, ir spectroscopy and mass spectrometry. the salicylaldimine ligands and complexes were screened for antiparasitic activity against two strains of plasmodium falciparum i.e. the nf54 cq-sensitive and k1 cq-resistant strain as well as against the g3 isolate of trichomonas vaginalis. the monomeric salicylaldim ... | 2015 | 26226082 |
| improved antiparasitic activity by incorporation of organosilane entities into half-sandwich ruthenium(ii) and rhodium(iii) thiosemicarbazone complexes. | a series of ferrocenyl- and aryl-functionalised organosilane thiosemicarbazone compounds was obtained via a nucleophilic substitution reaction with an amine-terminated organosilane. the thiosemicarbazone (tsc) ligands were further reacted with either a ruthenium dimer [(η(6-i)prc6h4me)ru(μ-cl)cl]2 or a rhodium dimer [(cp*)rh(μ-cl)cl]2 to yield a series of cationic mono- and binuclear complexes. the thiosemicarbazone ligands, as well as their metal complexes, were characterised using nmr and ir s ... | 2015 | 25559246 |
| conservation of transit peptide-independent protein import into the mitochondrial and hydrogenosomal matrix. | the origin of protein import was a key step in the endosymbiotic acquisition of mitochondria. though the main translocon of the mitochondrial outer membrane, tom40, is ubiquitous among organelles of mitochondrial ancestry, the transit peptides, or n-terminal targeting sequences (ntss), recognised by the tom complex, are not. to better understand the nature of evolutionary conservation in mitochondrial protein import, we investigated the targeting behavior of trichomonas vaginalis hydrogenosomal ... | 2015 | 26338186 |
| stop codon recognition in the early-diverged protozoans giardia lamblia and trichomonas vaginalis. | two classes of polypeptide release factors (rfs) are responsible for maintaining accuracy in translation termination; however, their detailed mechanism of action and evolutionary history of these factors remain elusive. the structure and function of rfs vary in bacteria and eukaryotes, a fact that is suggestive of evolutionary changes in the translation termination system. giardia lamblia (diplomonada) and trichomonas vaginalis (parabasalia) are considered as early-diverged eukaryotes. the class ... | 2015 | 26310515 |
| anti-retroviral lectins have modest effects on adherence of trichomonas vaginalis to epithelial cells in vitro and on recovery of tritrichomonas foetus in a mouse vaginal model. | trichomonas vaginalis causes vaginitis and increases the risk of hiv transmission by heterosexual sex, while tritrichomonas foetus causes premature abortion in cattle. our goals were to determine the effects, if any, of anti-retroviral lectins, which are designed to prevent heterosexual transmission of hiv, on adherence of trichomonas to ectocervical cells and on tritrichomonas infections in a mouse model. we show that trichomonas asn-linked glycans (n-glycans), like those of hiv, bind the manno ... | 2015 | 26252012 |
| vulvovaginitis: screening for and management of trichomoniasis, vulvovaginal candidiasis, and bacterial vaginosis. | to review the evidence and provide recommendations on screening for and management of vulvovaginal candidiasis, trichomoniasis, and bacterial vaginosis. | 2015 | 26001874 |
| trichomonas gypaetinii n. sp., a new trichomonad from the upper gastrointestinal tract of scavenging birds of prey. | in the context of an epidemiological study carried out by several wildlife recovery centers in spain, trichomonads resembling trichomonas gallinae were found in the oropharyngeal cavity of 2 egyptian vultures (neophron percnopterus) and 14 cinereous vultures (aegypius monachus) which did not show any symptoms of trichomonosis. in order to characterize them, these isolates along with seven other t. gallinae isolates obtained from different hosts and from different geographical origin were analyze ... | 2015 | 25273632 |
| is trichomonas tenax a parasite or a commensal? | trichomonas tenax is considered a commensal organism found under poor oral hygiene conditions. t. tenax presents morphological similarities with t. vaginalis, and there are doubts concerning whether this protist is a parasite and whether it is a genetic variant of t. vaginalis. this study aimed to investigate the capacity of t. tenax to cause mammalian cell damage and compare its cytotoxicity with that of t. vaginalis. protozoan-host cell interaction assays were performed with madin-darby canine ... | 2015 | 25835639 |
| successful treatment of refractory trichomonas vaginalis infection using intravenous metronidazole. | trichomonas vaginalis is a sexually transmitted protozoan infection resulting in a vulvo-vaginitis and altered vaginal discharge in symptomatic women. since its introduction in the 1960 s, metronidazole has been the first-line drug for trichomonal infection. other nitroimidazoles, such as tinidazole, are used as alternative regimens with similar activity but at a greater expense. treatment failure usually represents patient non-compliance or reinfection, although metronidazole resistance has pre ... | 2015 | 25161176 |
| drug-free chitosan coated poly(isobutylcyanoacrylate) nanoparticles are active against trichomonas vaginalis and non-toxic towards pig vaginal mucosa. | the present work reports a non-conventional therapeutic strategy based on the use of vaginally-applied formulations for the treatment of trichomoniasis due to trichomonas vaginalis without adding a drug. | 2015 | 25319099 |
| trichomonas vaginalis infections are rare among young patients attending an sti clinic in sweden. | 2015 | 25137630 | |
| modulation of dendritic cell function by trichomonas vaginalis-derived secretory products. | trichomoniasis caused by the parasitic protozoan trichomonas vaginalis is the most common sexually transmitted disease in the world. dendritic cells are antigen presenting cells that initiate immune responses by directing the activation and differentiation of naïve t cells. in this study, we analyzed the effect of trichomonas vaginalis-derived secretory products on the differentiation and function of dendritic cells. differentiation of bone marrow-derived dendritic cells in the presence of t. va ... | 2015 | 24965578 |
| epidemiology and laboratory characteristics of trichomonas vaginalis infection in croatian men with and without urethritis syndrome: a case-control study. | the main objective of this study is to determine the prevalence of trichomoniasis in men with and without symptoms of urethritis, with concomitant analysis of sociodemographic and behavioural specificities of both groups. also, the objective is to evaluate laboratory methods used in the diagnostics of this parasitic disease. | 2015 | 25568091 |
| emphysematous vaginitis. | emphysematous vaginitis is a rare condition, characterized by the presence of multiple gas-filled cysts in the vaginal and/or exocervical mucosa. although its etiology is not completely understood, it is self-limited, with a benign clinical course. vaginal discharge, sometimes bloody, and pruritus are the most common symptoms. chronic and acute inflammation can be found, and diseases that impair the immune system and pregnancy have been associated with this condition. | 2015 | 25551590 |
| direct diagnosis of trichomonas vaginalis infection on archived pap smears using nested pcr. | little information is available concerning pcr-based direct detection of trichomonas infections on archived pap (papanicolaou)-stained smears. this study investigates dna extraction and amplification from archived pap smears. trichomonas vaginalis is a parasitic protozoan that infects the urogenital tract of women. | 2015 | 25633887 |
| protocols for the routine screening of drug sensitivity in the human parasite trichomonas vaginalis. | trichomonas vaginalis is a sexually transmitted protozoan parasite of humans. treatment of trichomoniasis is almost completely dependent on the old drug metronidazole and is hampered by resistance. new drug development, like routine screening for drug resistance, has however been hampered by the lack of reliable screening protocols with sufficient throughput. here we report on two separate in vitro protocols that use fluorescent dyes and allow for standardized drug sensitivity testing on the req ... | 2015 | 25618339 |
| dithiocarbamate-thiourea hybrids useful as vaginal microbicides also show reverse transcriptase inhibition: design, synthesis, docking and pharmacokinetic studies. | prophylactic prevention is considered as the most promising strategy to tackle sti/hiv. twenty-five dithiocarbamate-thiourea hybrids (14-38) were synthesized as woman controlled topical vaginal microbicides to counter trichomonas vaginalis and sperm along with rt inhibition potential. the four promising compounds (18, 26, 28 and 33) were tested for safety through cytotoxic assay against human cervical cell line (hela) and compatibility with vaginal flora, lactobacillus. docking study of most pro ... | 2015 | 25592712 |
| comparison of four diagnostic techniques for detection of trichomonas vaginalis infection in females attending tertiary care hospital of north india. | trichomonas vaginalis causes a common sexually transmitted disease trichomoniasis, which may lead to increased risk of transmission of human immunodeficiency virus infection and other pelvic inflammatory diseases. wet mount examination is the most common test for diagnosis, but it has low sensitivity. acridine orange staining can be used for diagnosis, but it requires special microscopic facility. culture is considered as the gold standard, but it takes a long time for diagnosis. osom trichomona ... | 2015 | 25673589 |
| the recombinant prepro region of tvcp4 is an inhibitor of cathepsin l-like cysteine proteinases of trichomonas vaginalis that inhibits trichomonal haemolysis. | trichomonas vaginalis expresses multiple proteinases, mainly of the cysteine type (cps). a cathepsin l-like 34kda cp, designated tvcp4, is synthesized as a 305-amino-acid precursor protein. tvcp4 contains the prepro fragment and the catalytic triad that is typical of the papain-like cp family of clan ca. the aim of this work was to determine the function of the recombinant tvcp4 prepro region (pptvcp4r) as a specific inhibitor of cps. we cloned, expressed, and purified the recombinant tvcp4 prep ... | 2015 | 25499446 |
| trichomonas vaginalis origins, molecular pathobiology and clinical considerations. | to integrate a selection of the most recent data on trichomonas vaginalis origins, molecular cell biology and t. vaginalis interactions with the urogenital tract microbiota with trichomoniasis symptoms and clinical management. | 2015 | 25485651 |
| gene-expression analysis of cold-stress response in the sexually transmitted protist trichomonas vaginalis. | trichomonas vaginalis is the etiologic agent of trichomoniasis, the most common nonviral sexually transmitted disease in the world. this infection affects millions of individuals worldwide annually. although direct sexual contact is the most common mode of transmission, increasing evidence indicates that t. vaginalis can survive in the external environment and can be transmitted by contaminated utensils. we found that the growth of t. vaginalis under cold conditions is greatly inhibited, but rec ... | 2015 | 25440978 |
| natural and synthetic compound anti-trichomonas vaginalis: an update review. | trichomonas vaginalis is a flagellate protozoan that causes trichomonosis, a sexually transmitted disease of worldwide importance. however, the infection has long received much less attention than other parasitic and sexually transmitted diseases. this negligence leads to poor diagnosis and underestimated prevalence values, and consequently, it has been associated to increasing acquisition and transmission of hiv, pregnancy outcomes, infertility, pelvic inflammatory disease, and cervical and pro ... | 2015 | 25786392 |
| prevalence of trichomonas vaginalis infection among egyptian women using culture and latex agglutination: cross-sectional study. | this is a cross-sectional study carried out in the obstetrics and gynecology department at kasr al- ainy cairo university hospitals. | 2015 | 25783642 |