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inhibition of propionibacterium acnes associated biofilm formation by decanediol. 201627188522
comparison effect of azithromycin gel 2% with clindamycin gel 1% in patients with acne.acne vulgaris is the most common skin disease. local and systemic antimicrobial drugs are used for its treatment. but increasing resistance of propionibacterium acnes to antibiotics has been reported.201627169103
nasal and conjunctival screening prior to refractive surgery: an observational and cross-sectional study.to investigate bacterial flora of clinically healthy conjunctiva and nasal cavity among patients prior to refractive surgery, as well as the characteristics of patients with methicillin-resistant staphylococcus aureus (mrsa) colonisation.201627160843
osteomyelitis of the humerus caused by propionibacterium acnes.propionibacterium acnes is a fastidious slow-growing anaerobic gram-positive bacillus best known for causing acne. however, it only occasionally has been isolated from invasive infections. in that setting, slow growth and low virulence may lead to indolent presentations and diagnostic delays as illustrated by the following case.201627159477
influence of a polymerizable eugenol derivative on the antibacterial activity and wettability of a resin composite for intracanal post cementation and core build-up restoration.eugenol has been used in dentistry due to its ability to inhibit the growth of a range of microorganisms, including facultative anaerobes commonly isolated from infected root canals. the aim of this study was to evaluate the antibacterial activity of the experimental composites containing eugenyl methacrylate monomer (egma), a polymeric derivative of eugenol, against a range of oral bacteria, commonly associated with failure of coronal and endodontic restorations. in vitro composite behavior and ...201627130610
quantification of the antibody response to propionibacterium acnes in a patient with prosthetic valve endocarditis: - a case report.the isolation of propionibacterium acnes in blood cultures is often considered a contaminant. on rare occasions, p. acnes can cause severe infections, including endocarditis and intravascular prosthesis-associated infections. to evaluate the discrimination between a contaminant and a clinically relevant infection we used an ouchterlony test system to quantify the antibody response to p. acnes in a patient with a proven p. acnes endocarditis.201627126586
absence or low density of propionibacterium acnes in comedonal lesions of acne patients? a surface to inside study of skin fluorescence. 201627125260
microbiota of an italian grana-like cheese during manufacture and ripening, unraveled by 16s rrna-based approaches.the microbial ecology of cheese involves a rich and complex interaction between starter lactic acid bacteria and nonstarter lactic acid bacteria (nslab), mainly originating from raw milk and/or from the environment, that can contribute to the final characteristics of cheese. the aim of the present research was the exploration of the active microbiota by rna-based approaches during the manufacturing and ripening of a grana-like cheese. reverse transcriptase pcr (rt-pcr)-denaturing gradient gel el ...201627107125
propionibacterium acnes infected intervertebral discs cause vertebral bone marrow lesions consistent with modic changes.modic type i change (mc1) are vertebral bone marrow lesions adjacent to degenerated discs that are specific for discogenic low back pain. the etiopathogenesis is unknown, but occult discitis, in particular with propionibacteria acnes (p. acnes), has been suggested as a possible etiology. if true, antibiotic therapy should be considered for patients with mc1. however, this hypothesis is controversial. while some studies report up to 40% infection rate in herniated discs, others fail to detect inf ...201627101067
a silent ghost in the right atrium. 201627082775
efficacy of red or infrared light-emitting diodes in a mouse model of propionibacterium acnes-induced inflammation.laser/light-based devices may provide an alternative to conventional acne therapeutics in some patients with nonresponsive acne.201627081265
pulmonary mucosa-associated lymphoid tissue lymphoma associated with pulmonary sarcoidosis: a case report and literature review.differentiating low-grade lymphoma from preexisting sarcoidosis is difficult because of their pathological similarity. this article describes a case of pulmonary mucosa-associated lymphoid tissue lymphoma associated with pulmonary sarcoidosis. the patient, a 45-year-old japanese man, presented with a 10-year history of pulmonary sarcoidosis and 5-year history of ocular sarcoidosis with histologic findings. because only the right s3 lung nodule had gradually enlarged, partial resection was perfor ...201627067783
prosthetic valve endocarditis due to propionibacterium acnes.to study the characteristics of patients with propionibacterium acnes prosthetic valve endocarditis (pve) who required surgery.201627052748
which is the best treatment for prosthetic joint infections due to propionibacterium acnes: need for further biofilm in vitro and experimental foreign-body in vivo studies? 201627045190
zolav(®) (a p-carboethoxy-tristyrylbenzene derivative) [corrected]: a new antibiotic for the treatment of acne.acne is a prominent skin condition affecting >80% of teenagers and young adults and ~650 million people globally. isotretinoin, a vitamin a derivative, is currently the standard of care for treatment. however, it has a well-established teratogenic activity, a reason for the development of novel and low-risk treatment options for acne.201627042015
the challenge of propionibacterium acnes and revision shoulder arthroplasty: a review of current diagnostic options.propionibacterium acnes is the most common cause of infection after shoulder arthroplasty. whereas there are several methods that can aid in the diagnosis of p. acnes infection, there is not a single "gold standard" because of the difficulties inherent in identifying this bacterium. we present an evidence-based discussion of the demographic, clinical, and radiographic predictors of p. acnes infection and review the current options for diagnosis.201627038565
clinical analysis of propionibacterium acnes infection after total knee arthroplasty.propionibacterium acnes is a common cause of upper extremity arthroplasty infection and usually presents in an indolent subacute fashion. it is not well described how total knee arthroplasty (tka) patients infected with p acnes present.201627036925
microbiologic profile of infections in presumed aseptic revision spine surgery.intra-operative cultures may be obtained in revision spine surgery despite the absence of pre-operative clinical markers of infection. the microbiologic profile of culture positive cases in which there is no clear evidence of infection preoperatively has not been described. the aim of this investigation is to report on the microbiologic profile of unexpected culture positive revision spine surgery cases.201627026016
propionibacterium prosthetic joint infection: experience from a retrospective database analysis.with improved diagnostic methods and longer prosthesis indwelling time, the frequency of diagnosed propionibacterium prosthetic joint infections (pji) is increasing. data on clinical, microbiological, radiological and surgical treatment are limited, and importance of this organism in pji is probably underestimated.201627017334
physical modalities (devices) in the management of acne.treatment options for acne vulgaris are enhanced by laser and light therapy. both visible and laser light are effective treatments for acne. visible light and many lasers target propionibacterium acnes porphyrins while others act as anti-inflammatory mediators or reduce sebaceous gland activity. compared with topical and systemic therapies, laser and light therapies have few if any side effects and appear to be safe during pregnancy. if patients prefer at home light treatments, several devices a ...201627015782
the clinical relevance of antibiotic resistance: thirteen principles that every dermatologist needs to consider when prescribing antibiotic therapy.antibiotics are commonly used by dermatologists in clinical practice, primarily because of the overall track record of favorable efficacy and safety with the most commonly used agents. during the past decade, increased attention has been given to the problems associated with antibiotic resistance. this article summarizes important principles gleaned from the continued efforts of the scientific panel on antibiotic use in dermatology; other groups working diligently in this area, such as the cente ...201627015776
the relationship of proper skin cleansing to pathophysiology, clinical benefits, and the concomitant use of prescription topical therapies in patients with acne vulgaris.patients often perceive the cause of their acne to be related to a lack of proper cleansing, therefore many patients attempt to treat their acne either alone or with prescription therapy by frequent aggressive cleansing with harsh cleansing agents. altered epidermal barrier function, inflammation, and propionibacterium acnes are related to acne vulgaris (av) pathophysiology; proper cleansing can favorably modulate the development of av. the available clinical studies support gentle cleansing in ...201627015773
outcomes in the treatment of periprosthetic joint infection after shoulder arthroplasty: a systematic review.although many case series have been published on the treatment of shoulder periprosthetic joint infection (pji), few provide direct comparison of outcomes. this systematic review synthesizes the available english literature on shoulder pji to quantify treatment effectiveness.201627012542
propionibacterium acnes brain abscess in an immunocompetent man in the absence of prior neurosurgery.propionibacterium acnes is a rare, but established, cause of intracranial abscesses. we describe a case of p. acnes brain abscess in an immunocompetent man without prior neurosurgery. a 49-year old man with mild psoriasis presented with a two-week history of gait changes, generalized weakness and a two-day history of headaches, aphasia and confusion. imaging revealed a left thalamic mass and surgical biopsy suggested a pyogenic abscess. cultures of biopsy samples of the abscess grew p. acnes alo ...201626999913
[bacterial vaginosis: efficacy of a local treatment with a gel containing a fraction derived from propinibacterium acnes].bacterial vaginosis (bv) is favored by a decreased activity of vaginal immune system. the fraction derived from propionibacterium acnes is known to activate the immune system and is used parenterally to treat respiratory and urinary infections. the employ of a fraction derived from propionibacterium acnes locally, in the context of the vaginal immune system, is made possible by a vaginal gel in which this fraction is associated with hyaluronic acid, well-known for its moisturizing activity, and ...201626990097
an in vitro model for bacterial growth on human stratum corneum.the diversity and dynamics of the skin microbiome in health and disease have been studied recently, but adequate model systems to study skin microbiotas in vitro are largely lacking. we developed an in vitro system that mimics human stratum corneum, using human callus as substrate and nutrient source for bacterial growth. the growth of several commensal and pathogenic bacterial strains was measured for up to one week by counting colony-forming units or by quantitative pcr with strain-specific pr ...201626976779
discovery of a novel seminal fluid microbiome and influence of estrogen receptor alpha genetic status.bacteria harbored in the male reproductive system may influence reproductive function and health of the male and result in developmental origins of adult health and disease (dohad) effects in his offspring. such effects could be due to the seminal fluid, which is slightly basic and enriched with carbohydrates; thereby, creating an ideal habitat for microbes or a potential seminal fluid microbiome (sfm). using wild-type (wt) and estrogen receptor-alpha (esr1) knockout (ko) male mice, we describe ...201626971397
a myrtus communis extract enriched in myrtucummulones and ursolic acid reduces resistance of propionibacterium acnes biofilms to antibiotics used in acne vulgaris.recent works present evidence of propionibacterium acnes growing as a biofilm in cutaneous follicles. this formation of clusters is now considered as an explanation for the in vivo resistance of p. acnes to the main antimicrobials prescribed in acne vulgaris.201626969384
the formulation of bacteriophage in a semi solid preparation for control of propionibacterium acnes growth.to isolate and characterise phage which could lyse p. acnes and to formulate the phage into a delivery form for potential application in topical treatment of acne infection.201626964063
dilemmas surrounding the diagnosis of deep brain stimulation electrode infection without associated wound complications: a series of two cases.when wounds are benign, diagnosis of deep brain stimulation (dbs) electrode infection and associated intraparenchymal infection can be challenging. only a couple, such cases exist in literature. since infections of the central nervous system can be life-threatening, prompt diagnosis is necessary to prevent neurological injury. employed within the appropriate context, magnetic resonance imaging (mri) of the brain, as well as laboratory data and clinical presentation, may help guide diagnosis.201626958428
frequency and typing of propionibacterium acnes in prostate tissue obtained from men with and without prostate cancer.prostate cancer is the most common cancer among men in western countries but the exact pathogenic mechanism of the disease is still largely unknown. an infectious etiology and infection-induced inflammation has been suggested to play a role in prostate carcinogenesis and propionibacterium acnes has been reported as the most prevalent microorganism in prostatic tissue. we investigated the frequency and types of p. acnes isolated from prostate tissue samples from men with prostate cancer and from ...201627284286
endocarditis in patients with ascending aortic prosthetic graft: a case series from a national multicentre registry.endocarditis in patients with ascending aortic prosthetic graft (aapg) is a life-threatening complication. the purpose of this study was to examine the clinical presentation and prognosis of patients with aapg endocarditis included in a large prospective infectious endocarditis multicentre study.201627283156
synovitis, acne, pustulosis, hyperostosis, and osteitis (sapho) syndrome - a challenging diagnosis not to be missed.sapho syndrome manifests as chronic inflammation of bones and joints, which may or may not be accompanied by skin changes. the term sapho is an acronym that stands for synovitis, acne, pustulosis (usually palmoplantar), hyperostosis and osteitis. the bones most commonly affected are those in the anterior chest wall (mainly the sternum, clavicles and sternocostoclavicular joints), the vertebrae and the sacroiliac joints, but peripheral and flat bones may also be involved, especially in children. ...201627263075
propionibacterium namnetense sp. nov., isolated from a human bone infection.a polyphasic taxonomic study was performed on two gram-positive-staining, anaerobic, pleomorphic, rod-shaped strains isolated from human bone and tissue samples. sequencing of the 16s rrna genes revealed that the strains belong to a novel species within the genus propionibacterium, most closely related to propionibacterium acnes subsp. acnes and propionibacterium acnes subsp. elongatum with similarity values of 98.4 % and 98.1 %, respectively. in addition, protein-coding genes for rpob, reca and ...201627259292
propionibacterium acnes biofilm - a sanctuary for staphylococcus aureus?the purpose of this study was to measure the effect of combined culture of propionibacterium acnes and staphylococcus aureus on biofilm formation under different oxygen concentrations. we measured planktonic growth and biofilm formation of p. acnes and s. aureus alone and together under aerobic and anaerobic conditions. both p. acnes and s. aureus grew under anaerobic conditions. when grown under anaerobic conditions, p. acnes with or without s. aureus formed a denser biomass biofilm than did s. ...201627241780
unusual acute onset of abdominal aortic endograft infection by propionibacterium acnes after coil embolization for type ii endoleak.propionibacterium acnes, an anaerobic gram-positive bacillus that inhabits the skin, has rarely been incriminated in abdominal aortic endograft infection. it is usually responsible for typical delayed and low-grade postoperative infections. we report the case of a 66-year-old patient who developed acute p. acnes aortic stent-graft infection 9 days after percutaneous embolization for type ii endoleak. the stent graft had been implanted 2 years before. because of persistent signs of sepsis and dis ...201627238987
propionibacterium acnes induces an adjuvant effect in b-1 cells and affects their phagocyte differentiation via a tlr2-mediated mechanism.b-1 lymphocytes are present in large numbers in the mouse peritoneal cavity, as are macrophages, and are responsible for natural igm production. these lymphocytes migrate to inflammatory foci and are also involved in innate immunity. it was also demonstrated that b-1 cells are able to differentiated into phagocytes (b-1cdp), which is characterized by expression of f4/80 and increased phagocytic activity. b-1 cell responses to antigens and adjuvants are poorly characterized. it has been shown tha ...201627233619
the use of oral antibiotics in treating acne vulgaris: a new approach.although acne is not an infectious disease, oral antibiotics have remained a mainstay of treatment over the last 40 years. the anti-inflammatory properties of oral antibiotics, particularly the tetracyclines, are efficacious in treating inflammatory acne lesions. common prescribing practices in dermatology exert significant selection pressure on bacteria, contributing to the development of antibiotic resistance. antibiotic use for acne not only promotes resistance in propionibacterium acnes, but ...201627306750
is propionibacterium acnes related to disc degeneration in adults? a systematic review.to systematically review the evidence linking propionibacterium acnes with the development of symptomatic degenerative disc disease.201627603410
ten questions on prosthetic shoulder infection.prosthetic shoulder infection can cause significant morbidity secondary to pain and stiffness. symptoms may be present for years before diagnosis because clinical signs are often absent and inflammatory markers may be normal. an emerging common culprit, propionibacterium acnes, is hard to culture and so prolonged incubation is necessary. a negative culture result does not always exclude infection and new synovial fluid biochemical markers such as α defensin are less sensitive than for lower limb ...201627583013
erratum to: frequency and typing of propionibacterium acnes in prostate tissue obtained from men with and without prostate cancer.[this corrects the article doi: 10.1186/s13027-016-0074-9.].201627335583
inhibitory effects of schisandra chinensis extract on acne-related inflammation and uvb-induced photoageing.schisandra chinensis (turcz.) baill. (schisandraceae) fruit extract (sfe) has been reported to induce non-specific tissue protection against inflammation in vivo. however, the effects of sfe on propionibacterium acnes-stimulated acne and uvb-irradiated photoageing have yet to be investigated.201627328727
ereply. towards better understanding and management of propionibacterium acnes in cases of prosthetic valve endocarditis. 201627325659
ecomment. towards better understanding and management of propionibacterium acnes in cases of prosthetic valve endocarditis. 201627325658
saddle nose with sarcoidosis: "a great imitator" of relapsing polychondritis.sarcoidosis is a systemic granulomatous disease that can affect any organ including the nose. nasal crusting and congestion are common nasal symptoms of sarcoidosis, whereas cases of saddle-nose deformity are rarely reported. we describe here a case of sarcoidosis that presented with saddle nose resembling relapsing polychondritis. since sarcoidosis shares clinical features with relapsing polychondritis, the differential diagnosis of saddle nose can be challenging without a clear pathology.201627321667
draft genome sequence of highly rifampin-resistant propionibacterium namnetense nts 31307302t isolated from a patient with a bone infection.propionibacterium namnetense was recently described as a potential bone pathogen, which is closely related to propionibacterium acnes, a skin commensal microorganism. here, we report the draft genome sequence of the highly rifampin-resistant strain nts 31307302(t) isolated from a patient with a tibia infection.201627516511
evaluation of the antioxidative, antibacterial, and anti-inflammatory effects of the aloe fermentation supernatant containing lactobacillus plantarum hm218749.1.little work is done to develop aloe vera (av) using probiotics. to explore the potential benefits, the antioxidant effects and the antibacterial effects on foodborne pathogens of aloe fermentation supernatant were evaluated in vitro. our results indicated that the aloe fermentation supernatant fermented by lactobacillus plantarum hm218749.1 had very strong scavenging capacities of the dpph (86%), o2 (•-) (85%), (•)oh (76%), and fe(2+) chelation (82%) and reducing powers (242.5 mg/l), and the inh ...201627493450
analysis of postoperative thoracolumbar spine infections in a prospective randomized controlled trial using the centers for disease control surgical site infection criteria.wound infections following spinal surgery place a high toll on both the patient and the healthcare system. although several large series studies have examined the incidence and distribution of spinal wound infection, the applicability of these studies varies greatly since nearly every study is either retrospective and/or lacks standard inclusion criteria for defining surgical site infection. to address this void, we present results from prospectively gathered thoracolumbar spine surgery data for ...201627441172
heterogeneity and antibiotic resistance in propionibacterium acnes isolates and its therapeutic implications: blurring the lines between commensal and pathogenic phylotypes.acne vulgaris is a multifactorial skin disease associated with the colonization of propionibacterium acnes. antibiotics are a mainstay of treatment for acne, yet the emergence of resistance against the currently approved antibiotics is a serious concern. in this case report, a slow responder had multiple propionibacterium acnes isolates with varied levels of sensitivity to the conventional antibiotics. the bacterial isolates obtained from acne samples collected from the patient were analyzed for ...201627424878
drug eruption secondary to vancomycin-laden spacer in the shoulder: a case report. 201627422463
effects of 5-aminolevulinic acid photodynamic therapy on tlrs in acne lesions and keratinocytes co-cultured with p. acnes.to investigate the effect of 5-aminolevulinic acid photodynamic therapy (ala-pdt) on the expression of toll like receptors (tlrs) in human keratinocytes and its role in acne treatment.201627421917
recent progress in the research about propionibacterium acnes strain diversity and acne: pathogen or bystander?recent progress has steadily reported the existence of the diverse strains of propionibacterium acnes, and these studies have contributed to the elucidation of their contradictory roles between normal commensals and pathogens. in this review, the authors aimed to provide an update on the recent understanding of research about p. acnes strain diversity and acne, analyzing the potential implications for clinical applications. before the era of genomic research, p. acnes was known to be distinguish ...201627421121
antibiotic-resistant acne: getting under the skin.propionibacterium acnes is a key pathogenic factor in the development of acne. antibiotics are the first choice of treatment for mild-to-moderate, mixed, papular/pustular, and moderate nodular acne, and an alternative choice in severe, nodular/conglobate acne. the emergence of resistance to the currently available antibiotics poses a serious set-back to this algorithm, and the reduced arsenal can diminish efficacy of treatment. this emerging situation should catalyze innovations in dermatology; ...201627416310
topical and oral antibiotics for acne vulgaris.antibiotics, both oral and topical, have been an integral component of the management of acne vulgaris (av) for approximately 6 decades. originally thought to be effective for av due to their ability to inhibit proliferation of propionibacterium acnes, it is now believed that at least some antibiotics also exert anti-inflammatory effects that provide additional therapeutic benefit. to add, an increase in strains of p acnes and other exposed bacteria that are less sensitive to antibiotics used to ...201627416309
glove contamination during endodontic treatment is one of the sources of nosocomial endodontic propionibacterium acnes infections.the opportunistic propionibacterium acnes recovered frequently from failed endodontic treatments might be the result of nosocomial endodontic infections. the study was aimed to determine if gloves worn by dentists could be one of the sources of these nosocomial infections and to investigate the p. acnes phylotypes involved.201627395473
thoracic aortic graft infections secondary to propionibacterium species: two cases and review of the literature.aortic graft infections are a rare occurrence, most commonly secondary to gram-positive organisms (staphylococcus and streptococcus species). we present 2 cases of thoracic aortic graft infections secondary to anaerobic bacteria, propionibacterium species. the first case, a 40-year-old male, was found to have an anastomotic aneurysm at the distal anastomosis of a previous thoracoabdominal aneurysm repair. during the open repair of his anastomotic aneurysm, the original graft was not incorporated ...201627381316
antimicrobial activity of sebocytes against propionibacterium acnes via toll-like receptor 2 and lysosomal pathway. 201627375109
propionibacterium avidum as an etiological agent of prosthetic hip joint infection.propionibacterium acnes is well-established as a possible etiologic agent of prosthetic joint infections (pjis). other propionibacterium spp. have occasionally been described as a cause of pjis, but this has not previously been the case for p. avidum despite its capacity to form biofilm. we describe two patients with prosthetic hip joint infections caused by p. avidum. both patients were primarily operated with an anteriorly curved skin incision close to the skin crease of the groin, and both we ...201627355425
strains of the propionibacterium acnes type iii lineage are associated with the skin condition progressive macular hypomelanosis.progressive macular hypomelanosis (pmh) is a common skin disorder that causes hypopigmentation in a variety of skin types. although the underlying aetiology of this condition is unclear, there is circumstantial evidence that links the skin bacterium propionibacterium acnes to the condition. we now describe the first detailed population genetic analysis of p. acnes isolates recovered from paired lesional and non-lesional skin of pmh patients. our results demonstrate a strong statistical associati ...201627555369
anti-acne, anti-dandruff and anti-breast cancer efficacy of green synthesised silver nanoparticles using coriandrum sativum leaf extract.in this present investigation, agnps were green synthesised using coriandrum sativum leaf extract. the physicochemical properties of agnps were characterised using uv-visible spectrophotometer, field emission scanning microscopy/energy dispersive x-ray (fesem/edx), fourier transformed infrared spectroscopy (ft-ir), x-ray diffraction (xrd) and brunauer-emmett-teller (bet) analysis. further, in vitro anti-acne, anti-dandruff and anti-breast cancer efficacy of green synthesised agnps were assessed ...201627541567
prevalence of propionibacterium acnes in intervertebral discs of patients undergoing lumbar microdiscectomy: a prospective cross-sectional study.the relationship between intervertebral disc degeneration and chronic infection by propionibacterium acnes is controversial with contradictory evidence available in the literature. previous studies investigating these relationships were under-powered and fraught with methodical differences; moreover, they have not taken into consideration p. acnes' ability to form biofilms or attempted to quantitate the bioburden with regard to determining bacterial counts/genome equivalents as criteria to diffe ...201627536784
a novel 23s rrna mutation in propionibacterium acnes confers resistance to 14-membered macrolides. 201627530860
[confusion over the term "contamination rate" as it pertains to blood cultures].the blood culture contamination rate is often used to validate specimen-collection procedures. cumitech has set its optimal target to be 2% to 3%. however, the term "contamination rate" has been defined in many ways, limiting its generalizability. the definitions used in earlier studies can be divided into two categories; definitions based on clinical judgements, and those based on preset rules. according to each principle, the equation must be composed of a defined numerator and denominator. th ...201627529972
treatment modalities for acne.acne is a common inflammatory skin disease which affects the pilosebaceous units of the skin. it can have severe psychological effects and can leave the patient with severe skin scarring. there are four well-recognized pathological factors responsible for acne which is also the target for acne therapy. in this review, different treatment options are discussed, including topical (i.e., retinoids, and antibiotics) and systemic (i.e., retinoids, antibiotics, and hormonal) treatments. since the gene ...201627529209
incidence of propionibacterium acnes in initially culture-negative thioglycollate broths-a prospective cohort study at a danish university hospital.the aim of this study was to prospectively investigate the incidence of propionibacterium acnes in thioglycollate broths reported as culture-negative at the department of clinical microbiology, rigshospitalet, to evaluate whether 5 days of incubation was enough to find all relevant cases. five hundred thioglycollate broths reported as culture-negative after 5 days were consecutively collected and incubated for at least a further 9 days (at least 14 days of incubation in total). only tissue sampl ...201627521804
sequential antimicrobial treatment with linezolid for neurosurgical infections: efficacy, safety and cost study.evidence for the effectiveness of linezolid in neurosurgical infections (nsis) is growing. the comfortable oral dosage and tolerance of linezolid opens the possibility for sequential antimicrobial treatment (sat) in stable patients after a period of intravenous treatment.201627520361
propionibacterium acnes infection associated with cancerous prostate hypertrophy. 201627629109
evaluation of intraoperative glove change in prevention of postoperative cerebrospinal fluid shunt infections, and the predictors of shunt infection.we have previously suggested that surgical gloves could be a possible means for transferring microorganisms from skin flora to shunt material during surgery. the objectives of this study were to examine (1) whether the rate of shunt infections was reduced after introducing intraoperative glove change before handling the shunt material; (2) clinical presentation of shunt infections, microbiological data, and treatment management; and (3) predictors of shunt infections.201627626705
assessment of a new biological complex efficacy on dysseborrhea, inflammation, and propionibacterium acnes proliferation.acne vulgaris is a common chronic inflammatory disease of the pilosebaceous unit triggered by propionibacterium acnes. a bakuchiol, ginkgo biloba extract, and mannitol (bgm) complex has been developed to provide patients with acne with a specific dermocosmetic to be used adjunctively with conventional treatments.201627621660
delayed propionibacterium acnes surgical site infections occur only in the presence of an implant.whether propionibacterium acnes (p. acnes) causes surgical-site infections (ssi) after orthopedic surgery is controversial. we previously reported that we frequently find p. acnes in intraoperative specimens, yet none of the patients have clinically apparent infections. here, we tracked p. acnes for 6 months in a mouse osteomyelitis model. we inoculated p. acnes with an implant into the mouse femur in the implant group; the control group was treated with the bacteria but no implant. we then obse ...201627615686
animal models of implant-related low-grade infections. a twenty-year review.the demand for joint replacement and surgical treatment is continuously increasing, thus representing a clinical burden and a cost for the healthcare system. among several pathogens involved in implant-related infections, staphylococci account for the two-thirds of clinically isolated bacteria. despite most of them are highly virulent microorganisms (staphylococcus aureus, escherichia coli, pseudomonas aeruginosa), low virulent bacteria (staphylococcus epidermidis, propionibacterium acnes) are r ...201627718217
lack of effectiveness of antibiotics in chronic low back pain with modic 1 changes. 201627697400
de novo propionibacterium acnes septic arthritis.we report the third identifiable case of septic arthritis due to propionibacterium acnes arising in the absence of prior surgical intervention. this anaerobic gram-positive bacillus is now recognised as an important cause of postoperative infections, typically presenting in an indolent fashion some months after surgery. reports of de novo septic arthritis due to p. acnes are exceedingly rare. our case adds to the literature and significantly broadens the reported pathogenic potential of the orga ...201627671986
arid5a exacerbates ifn-γ-mediated septic shock by stabilizing t-bet mrna.adenine-thymine (at)-rich interactive domain containing protein 5a (arid5a) is an rna-binding protein that has been shown to play an important immune regulatory function via the stabilization of il-6 and stat3 mrna. however, the role of arid5a in the overwhelming and uncontrolled immune response that leads to septic shock is unknown. here, we report that arid5a-deficient mice are highly resistant to lipopolysaccharide (lps)-induced endotoxic shock and secrete lower levels of major proinflammator ...201627671645
proposal to reclassify propionibacterium acnes type i as propionibacterium acnes subsp. acnes subsp. nov. and propionibacterium acnes type ii as propionibacterium acnes subsp. defendens subsp. nov.recently, it has been proposed that strains of propionibacterium acnes from the type iii genetic division should be classified as p. acnessubsp. elongatum subsp. nov., with strains from the type i and ii divisions collectively classified as p. acnessubsp. acnes subsp. nov. under such a taxonomic re-appraisal, we believe that types i and ii should also have their own separate rank of subspecies. in support of this, we describe a polyphasic taxonomic study based on the analysis of publicly availab ...201627670798
propionibacterium acnes, coagulase-negative staphylococcus, and the "biofilm-like" intervertebral disc.patients scheduled for spinal surgery were screened prospectively for a microbial presence associated with intervertebral disc specimens. inclusion was limited to patients requiring surgery for any of five conditions: study patients with cervical spine intervertebral herniation (ivh), lumbar spine ivh, lumbar spine discogenic pain, and control patients with idiopathic scoliosis/scheurermann's kyphosis or trauma/neuromuscular deformity. exclusion criteria included ongoing systemic infection, abno ...201627669046
isolation of propionibacterium acnes among the microbiota of primary endodontic infections with and without intraoral communication.the presence of opportunistic pathogens such as propionibacterium acnes (p. acnes) may contribute to the endodontic pathology. the presence of p. acnes may be influenced by different endodontic conditions. the aims of the study were firstly, to identify p. acnes within the whole cultivable microbiota of primary endodontic infections, to investigate which p. acnes phylotypes predominate in such infections and secondly to determine if the presence of an "open" communication (e.g. a sinus) can be a ...201626856712
effect of vitamin d on the expression of inflammatory biomarkers in cultured sebocytes treated with propionibacterium acnes or ultraviolet b irradiation. 201627746658
propionibacterium acnes inhibits foxm1 and induces cell cycle alterations in human primary prostate cells.propionibacterium acnes has been detected in diseased human prostate tissue, and cell culture experiments suggest that the bacterium can establish a low-grade inflammation. here, we investigated its impact on human primary prostate epithelial cells. microarray analysis confirmed the inflammation-inducing capability of p. acnes but also showed deregulation of genes involved in the cell cycle. qpcr experiments showed that viable p. acnes downregulates a master regulator of cell cycle progression, ...201627424770
reduced ability to detect surface-related biofilm bacteria after antibiotic exposure under in vitro conditions.background and purpose - antibiotic treatment of patients before specimen collection reduces the ability to detect organisms by culture. we investigated the suppressive effect of antibiotics on the growth of non-adherent, planktonic, and surface-related biofilm bacteria in vitro by using sonication and microcalorimetry methods. patients and methods - biofilms of staphylococcus aureus, s. epidermidis, escherichia coli, and propionibacterium acnes were formed on porous glass beads and exposed for ...201627775462
propionibacterium acnes susceptibility and correlation with hemolytic phenotype.many studies have noted an increase in the number of recognized cases of invasive infections due to propionibacterium acnes, especially after shoulder replacement surgery. the increase in the number of recognized cases of p. acnes, a nonspore-forming, anaerobic, gram-positive organism, appears due to both an increase in the number of shoulder operations being performed and more specimens being sent for anaerobic cultures. nevertheless, the optimal surgical and antibiotic management of p. acnes r ...201627773990
different propionibacterium acnes phylotypes induce distinct immune responses and express unique surface and secreted proteomes.propionibacterium acnes is a skin commensal bacterium that contributes to the development of acne vulgaris and other infections. recent work revealed that p. acnes clinical isolates can be classified into distinct phylotypes, several of which have associations with healthy skin or acne. we sought to determine if these phylotypes induce different immunological responses and express protein factors that may contribute to their disease associations. we found that acne-associated p. acnes phylotypes ...201627377696
two cases of non-prosthetic bone and joint infection due to propionibacterium acnes. 201626507785
propionibacterium acnes overabundance and natural killer group 2 member d system activation in corpus-dominant lymphocytic gastritis.corpus-dominant lymphocytic gastritis (lyg) is characterized by cd8(+) t-cell infiltration of the stomach epithelium by a so far uncharacterized mechanism. although helicobacter pylori is typically undetectable in lyg, patients respond to h. pylori antibiotic eradication therapy, suggesting a non-h. pylori microbial trigger for the disease. comparative microbiota analysis of specimens from lyg, h. pylori gastritis and healthy controls precluded involvement of h. pylori in lyg but identified prop ...201627538697
transcriptomic analysis of propionibacterium acnes biofilms in vitro.propionibacterium acnes is a well-known commensal of the human skin connected to acne vulgaris and joint infections. it is extensively studied in planktonic cultures in the laboratory settings but occurs naturally in biofilms. in this study we have developed an in vitro biofilm model of p. acnes and studied growth features, matrix composition, matrix penetration by fluorescent-labeled antibiotics as well as gene expression. antibiotic susceptibility of biofilms was studied and could be enhanced ...201627725231
a novel enzyme with antioxidant capacity produced by the ubiquitous skin colonizer propionibacterium acnes.the role of the skin microbiota in human health is poorly understood. here, we identified and characterized a novel antioxidant enzyme produced by the skin microbiota, designated roxp for radical oxygenase of propionibacterium acnes. roxp is uniquely produced by the predominant skin bacterium p. acnes, with no homologs in other bacteria; it is highly expressed and strongly secreted into culture supernatants. we show that roxp binds heme, reduces free radicals, and can protect molecules from oxid ...201627805044
in vitro antimicrobial susceptibility patterns of propionibacterium acnes isolated from patients with acne vulgaris.propionibacterium acnes has been implicated in the development of acne vulgaris. rampant use of topical and systemic antibiotics for acne vulgaris has led to resistance due to selective pressure. this study aimed to determine antibiotic resistance of p. acnes.201627801379
optimal length of cultivation time for isolation of propionibacterium acnes in suspected bone and joint infections is more than 7 days.diagnosis of propionibacterium acnes bone and joint infection is challenging due to the long cultivation time of up to 14 days. we retrospectively studied whether reducing the cultivation time to 7 days allows accurate diagnosis without losing sensitivity. we identified patients with at least one positive p. acnes sample between 2005 and 2015 and grouped them into "infection" and "no infection." an infection was defined when at least two samples from the same case were positive. clinical and mic ...201627733637
emergence of fluoroquinolone-resistant propionibacterium acnes caused by amino acid substitutions of dna gyrase but not dna topoisomerase iv.with the aim of elucidating the mechanisms of fluoroquinolones resistance in propionibacterium acnes, we determined the susceptibility of fluoroquinolones in 211 isolates from patients with acne vulgaris. we identified five isolates (2.4%) with reduced susceptibility to nadifloxacin (minimum inhibitory concentration ≥ 4 μg/ml). determination of the sequences of the dna gyrase (gyra and gyrb) and dna topoisomerase (parc and pare) genes showed the amino acid substitutions ser101leu and asp105gly o ...201627793740
two-stage revision for infected shoulder arthroplasty.periprosthetic shoulder infections (psis) are challenging to treat and often result in significant patient morbidity. without a standardized treatment protocol, psis are often managed similarly to periprosthetic hip and knee infections. because 2-stage revision is the gold standard for treating periprosthetic hip and knee infections, we performed a case series and literature review to determine its effectiveness in psis.201627887875
draft genome sequences of four propionibacterium acnes strains isolated from implant-related infections.propionibacterium acnes was previously described as a potential implant-related pathogen. here, we report the draft genome sequence of four p. acnes strains, isolated from spine material, hip arthroplasty, and knee arthroplasty infections in france belonging to different sequence types (st18, st27, and st36).201627979946
solitary tentorial sarcoid granuloma associated with propionibacterium acnes infection: case report.sarcoidosis is a systemic granulomatous disease with unknown cause, which very rarely occurs exclusively in the central nervous system. the authors performed biopsy sampling of a mass that developed in the left tentorium cerebelli that appeared to be a malignant tumor. the mass was diagnosed as a sarcoid granuloma, which was confirmed with the onset of antibody reaction product against propionibacterium acnes. findings suggesting sarcoidosis to be an immune response to p. acnes infection have re ...201627885956
modic changes in the adjacent vertebrae due to disc material infection with propionibacterium acnes in patients with lumbar disc herniation.modic changes (mcs) in vertebral bones are induced by two mechanisms of mechanical factors and infection. as propionibacterium acnes (p. acnes) have been reported to be associated with lbp. the aim of this study is to evaluate the mcs in patients with disc herniation and positive for p. acnes.201627885471
contamination of the surgical field with propionibacterium acnes in primary shoulder arthroplasty.propionibacterium acnes is a common pathogen identified in postoperative shoulder infection. it has been shown to be present in culture specimens during primary shoulder arthroplasty; however, recent work has suggested that it is most likely to be a contaminant. our aim was to identify the potential sources of contamination in shoulder arthroplasty.201627869623
lipase-sensitive transfersomes based on photosensitizer/polymerizable lipid conjugate for selective antimicrobial photodynamic therapy of acne.acne vulgaris is a common skin problem affecting nearly 90% of adolescents and its development is associated with a colonization of propionibacterium acnes (p. acnes). although antibiotics have commonly been used to treat acne, antibiotic resistance of p. acnes is an emerging issue to be solved. in this study, a new way of photodynamic acne therapy is developed using p. acnes lipase-sensitive transfersome (dspe-peg-pheo a (dpp) transfersome). for enhanced selectivity and skin penetration efficie ...201627863184
propionibacterium skull base osteomyelitis complicated by internal carotid artery pseudoaneurysm.the microbiology of skull base osteomyelitis (sbo) is evolving. we present here the first case of sbo caused by propionibacterium acnes leading to the development of a pseudoaneurysm of the internal carotid artery. otolaryngologists should recognize this pathogen as a potential cause of invasive temporal bone infection to optimize prompt diagnosis and treatment. laryngoscope, 2016.201627861948
a precision microbiome approach using sucrose for selective augmentation of staphylococcus epidermidis fermentation against propionibacterium acnes.acne dysbiosis happens when there is a microbial imbalance of the over-growth of propionibacterium acnes (p. acnes) in the acne microbiome. in our previous study, we demonstrated that staphylococcus epidermidis (s. epidermidis, a probiotic skin bacterium) can exploit glycerol fermentation to produce short-chain fatty acids (scfas) which have antimicrobial activities to suppress the growth of p. acnes. unlike glycerol, sucrose is chosen here as a selective fermentation initiator (sfi) that can sp ...201627834859
propionibacterium acnes: time-to-positivity in standard bacterial culture from different anatomical sites.propionibacterium acnes infections are likely under-recognized and underreported. this is partly because of low clinical suspicion, perceived non-pathogenicity, or lack of adequate culture incubation time. we conducted a study to assess the optimal incubation period to recover p. acnes from specimens acquired during the workup of suspected clinical infections.201627829959
chronic post-operative iris prosthesis endophthalmitis in a patient with traumatic aniridia: a case report.post-operative endophthalmitis is a serious complication of intraocular surgery which may present acutely or chronically. chronic post-operative endophthalmitis is characterized by decreased visual acuity, mild pain, and low-grade uveitis several weeks or months after intraocular surgery which may be responsive to corticosteroids, but recur upon tapering. low virulence organisms such as propionibacterium acnes are the most common culprit organisms, and treatment most often consists of both intra ...201627829389
tlr-2 recognizes propionibacterium acnes camp factor 1 from highly inflammatory strains.propionibacterium acnes (p. acnes) is an anaerobic, gram-positive bacteria encountered in inflammatory acne lesions, particularly in the pilosebaceous follicle. p. acnes triggers a strong immune response involving keratinocytes, sebocytes and monocytes, the target cells during acne development. lipoteicoic acid and peptidoglycan induce the inflammatory reaction, but no p. acnes surface protein interacting with toll-like receptors has been identified. p. acnes surface proteins have been extracted ...201627902761
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