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therapeutic drug monitoring. 20102863512
the antineoplastic effect of methylprednisolone pulse therapy in two patients with glucocorticoid receptor-positive glioblastoma multiforme.glucocorticoids in high concentrations inhibit in vitro the growth rate of glioblastoma multiforme. this presupposes the presence of glucocorticoid receptors in the cytoplasma. glucocorticoid receptor positive patients with histological glioblastoma multiforme were postoperatively treated with high dose methylprednisolone pulse therapy during which ct-scanning initially demonstrated tumor regression. one patient's tumor size was unchanged after 24 weeks, whereas in the other patient, the tumor s ...20102833058
metaphyseal dysostosis schmidt type. 20103251840
[neoplastic hypercalcemia with renal insufficiency: treatment with dichloromethylene diphosphonate]. 20102935356
dual action of excitatory amino acids on the metabolism of inositol phosphates in striatal neurons.glutamate is able to stimulate inositol phosphate (ip) formation in striatal neurons in primary culture, mainly via an excitatory amino acid receptor of the quisqualate subtype. in the present study we show that carbachol (carb)-(a cholinergic agonist), but not neurotensin or norepinephrine-induced ip production could be reduced by 40% when measured in the presence of glu. the inhibition of the carb response by glu was dose dependent and reproduced by n-methyl-d-aspartate (nmda). quisqualate eli ...20102890092
the acth stimulation test in depression. 20103037614
the acth stimulation test in depression. 20103037614
a program for in vitro fertilization and embryo transfer at the southern california fertility institute, inc. 20102932511
somatostatin octapeptide (sms 201-995) in the medical treatment of acromegaly.parenteral somatostatin has been used to suppress growth hormone secretion in acromegalic patients, but long-term treatment is hampered by its short half-life of a few minutes in the circulation. an octapeptide analogue of somatostatin (sms 201-995) has recently been developed that has greater potency and selectivity in suppressing growth hormone than the native hormone. in this study somatostatin and somatostatin octapeptide infusions were compared in 13 patients with active acromegaly. the oct ...20102876497
[prognosis of obstetrical hemorrhages in multiparous women]. 20102955711
sulphadiazine desensitisation in aids patients. 20092857234
history of medicine in alaska. harriet crocker jackson schirmer, m.d. 20092662801
elevation of factor vii activity and mass in young adults at risk of ischemic heart disease.the northwick park heart study found that elevation of factor vii in middle-aged subjects was an independent risk factor for subsequent ischemic heart disease. the present study was designed to determine whether factor vii elevation is present at a younger age and whether zymogen or activated factor vii is responsible for this elevation. a group of 20 asymptomatic first degree relatives (mean age 34.9 years) of patients with premature ischemic heart disease were compared with 15 age-matched norm ...20092794283
[written information on prescribed drugs provided by pharmacies]. 20092815030
[written information on prescribed drugs provided by pharmacies]. 20092815030
arthropathy of the wrist in leprosy--what changes are caused by long-standing peripheral nerve palsy?a radiographical screening study of 338 leprotic patients was performed. clinically, according to a nerve score (ns) designed by us, 12.9% of 674 hands showed mild nerve palsy (ns 5 or 6), 75.9% moderate (ns 3 or 4), and 11.4% severe (ns less than 2). twenty-nine hands of 26 patients (ns 4.2 on average) demonstrated abnormal changes of the wrist joint on radiographs. we classified them into four groups: (a) lunate collapse (four patients), (b) scaphoid nonunion (eight), (c) scaphoid cyst (three) ...20092774872
[treatment of cancer of the bladder]. 20092653234
morning glory syndrome associated with marked persistent hyperplastic primary vitreous and lens colobomas.a case of morning glory syndrome with striking persistence of primary vitreous is presented. the hypothesis that the syndrome is an expression of abnormal closure of the embryonic fissure is substantiated by the coexistence of lens colobomas. furthermore, the marked primary vitreous hyperplasia shows the way in which persistence of primary vitreous influences the clinical expression with respect to optic pit and colobomas of the optic nerve.20092765452
consumer use of nondispensing professional pharmacy services.this study attempted to identify and develop an understanding of the use of 13 nondispensing services (ndss) by consumers in the community pharmacy practice setting. a self-administered, postage prepaid questionnaire was sent to 1000 indiana consumers randomly selected from telephone directories. a 45.5 percent response rate was achieved after one original mailing and two follow-ups. most consumers had not used ndss except for advice on nonprescription drugs and advice on minor health problems. ...20092718499
failla memorial lecture. the search for critical cellular targets damaged by heat. 20092694212
antihypertensive therapy: newer concepts and agents.major advances have taken place in recent years with respect to our understanding of hypertensive diseases, the mechanisms of action of other therapeutic agents, and the introduction of new classes of drugs. standard therapy today uses the basic of employing nonpharmacological modalities. thereafter a stepped-care program with pharmacological entities has been advocated using diuretic, antiadrenergic, and vasodilating agents. however, new modes of action have been introduced therapeutically duri ...20092866842
[radioactivity of air in the vicinity of medical linear accelerators].some mathematical expressions are given for the calculation of the activity concentration (13n,15o) in the surroundings of medical electron accelerators with a maximum photon energy up to 25 mev. the author differentiates between prolonged irradiations typical of physical operation or maintenance work and shorter irradiations separated into fractions which are typical of the treatment of patients. in most cases the calculated concentrations are considerably lower than the limit values valid e.g. ...20092772819
progress in the functional analysis of rickettsial genes through directed mutagenesis of rickettsia prowazekii phospholipase d. 200919995185
cluster of sylvatic epidemic typhus cases associated with flying squirrels, 2004-2006.in february 2006, a diagnosis of sylvatic epidemic typhus in a counselor at a wilderness camp in pennsylvania prompted a retrospective investigation. from january 2004 through january 2006, 3 more cases were identified. all had been counselors at the camp and had experienced febrile illness with myalgia, chills, and sweats; 2 had been hospitalized. all patients had slept in the same cabin and reported having seen and heard flying squirrels inside the wall adjacent to their bed. serum from each p ...200919624912
molecular detection of bartonella quintana in human body lice from mexico city. 200919793127
the realities of biodefense vaccines against rickettsia.rickettsia prowazekii, r. rickettsii, r. conorii, and r. typhi are serious biologic weapon threats because of high infectivity of low dose aerosols, stable small particle aerosol infectivity, virulence causing severe disease, difficulty in establishing a timely diagnosis, ineffectiveness of usual empiric treatments, potential for engineered complete antimicrobial resistance, lower level of immunity, availability of the agents in nature, and feasibility of propagation, stabilization, and dispersa ...200919837287
louse- and flea-borne rickettsioses: biological and genomic analyses.in contrast to 15 or more validated and/or proposed tick-borne spotted fever group species, only three named medically important rickettsial species are associated with insects. these insect-borne rickettsiae are comprised of two highly pathogenic species, rickettsia prowazekii (the agent of epidemic typhus) and r. typhi (the agent of murine typhus), as well as r. felis, a species with unconfirmed pathogenicity. rickettsial association with obligate hematophagous insects such as the human body l ...200919036234
rickettsia prowazekii infection of endothelial cells increases leukocyte adhesion through alphavbeta3 integrin engagement. 200919438625
directed mutagenesis of the rickettsia prowazekii pld gene encoding phospholipase d.rickettsia prowazekii, the causative agent of epidemic typhus, is an obligately intracytoplasmic bacterium, a lifestyle that imposes significant barriers to genetic manipulation. the key to understanding how this unique bacterium evades host immunity is the mutagenesis of selected genes hypothesized to be involved in virulence. the r. prowazekii pld gene, encoding a protein with phospholipase d activity, has been associated with phagosomal escape. to demonstrate the feasibility of site-directed ...200919506016
prediction of rickettsial skin eschars in humans using an experimental guinea pig model.until now, when a new rickettsia species was isolated in a tick, it was not possible to predict whether it was a human pathogen or if it would cause a skin eschar at the infection site. guinea pigs are injected intradermally with 25 different rickettsia species or subspecies: 16 induced an eschar, 5 induced inflammatory lesions and 4 have no effect. we observed that the occurrence of skin eschars in this model was significantly correlated (p <0.05) with observations of skin eschars in humans (14 ...200919527779
mitochondrial porin vdac 1 seems to be functional in rickettsial cells.we have recently shown that rickettsia prowazekii (typhus group rickettsiae) cells incorporate human mitochondrial porin vdac1. here, i report on the import of porin by rickettsiae of spotted fever group. it was shown that rickettsial cells of heavy band of renografin density gradient, known as permeabilized rickettsiae, contain much more vdac 1 compared to the cells of light band, that is, non-permeabilized rickettsiae. these data hint at a functionality of mitochondrial porin in rickettsial ce ...200919538262
ecology of rickettsia in south america.until the year 2000, only three rickettsia species were known in south america: (i) rickettsia rickettsii, transmitted by the ticks amblyomma cajennense, and amblyomma aureolatum, reported in colombia, argentina, and brazil, where it is the etiological agent of rocky mountain spotted fever; (ii) rickettsia prowazekii, transmitted by body lice and causing epidemic typhus in highland areas, mainly in peru; (iii) rickettsia typhi, transmitted by fleas and causing endemic typhus in many countries. d ...200919538276
men of peace and the search for the perfect pesticide: conscientious objectors, the rockefeller foundation, and typhus control research. 200919618798
[single photon emission computed tomography by using n-isopropyl-p-[123i]-iodoamphetamine and 99mtc-hexamethyl propyleneamine oxime in a patient with herpes simplex encephalitis].single photon emission computed tomographies (spects) by using n-isopropyl-p-[123i-imp]-iodo-amphetamine (123i-imp) and 99mtc-hexamethyl propyleneamine oxime (99mtc-hm-pao) were serially performed in a 70 yrs. old male with herpes simplex encephalitis (hse), and the chronological changes of accumulations were studied. accumulations of both 123i-imp and 99mtc-hm-pao increased initially, and then decreased with the stage of hse being advanced. the sequential appearance of the lesion in hse with 12 ...20092786584
meta-analysis: appropriate tool for the integration of nursing research? 20092798158
[the staghorn calculus: anatrophic nephrolithotomy versus percutaneous litholapxy and extracorporeal shockwave therapy versus extracorporeal shockwave lithotripsy monotherapy. a report of over 6 years' experience].from 1982 to december 1987, 71 with incomplete (c4 by rocco) and 37 with complete (c5 by rocco) staghorn calculi underwent anatrophic nephrolithotomy (an; n = 29), or combined percutaneous nephrostolithotomy and eswl (pcnl + eswl; n = 21), or eswl monotherapy without or with preoperative jj stenting (n = 37/21). the patients with incomplete staghorn calculi (c4) and preoperative ureteral stenting were free of stones after 6 months in 15 of 17 cases (88%), which is comparable to our results with ...20092741262
sce induction by ccnu and pregnancy. 20092704378
[plastic surgery in otorhinolaryngology: reconstruction flaps in oncologic surgery]. 20092701493
levels and sources of stress in medical students.levels of stress, as measured by the general health questionnaire, were assessed in 318 medical students in their fourth year at three british universities. mean scores were higher than those in other groups within the general population, and the estimated prevalence of emotional disturbance was 31.2%, a proportion similar to that reported in medical students in the united states. there were no differences in prevalence or in mean scores of stress between the sexes. twelve (4%) students reported ...20093085772
mast cell-mediated inflammation in asthma. 20092688493
effects of x-ray irradiation on natural killer (nk) cell system. ii. increased sensitivity to natural killer cytotoxic factor (nkcf).irradiation with low-doses of x-rays of tumor cells elevated their susceptibility to lysis by natural killer (nk) cells in an accompanying paper. cytotoxicity assays conducted at the single cell level revealed that x-ray irradiation of k562 cells did not affect the number of effector-target conjugates but increased the frequency of dead conjugated target cells. during interaction with k562 cells large granular lymphocytes released a soluble cytotoxic factor (nkcf) that killed the target cells. x ...20092621326
subclinical wilms' tumor in incomplete drash syndrome. 20092820862
subclinical wilms' tumor in incomplete drash syndrome. 20092820862
cyclosporin a inhibits activation-induced cell death in t-cell hybridomas and thymocytes.one mechanism by which the immune system develops the ability to discriminate self from nonself is the deletion of autoreactive t-cell clones during thymic maturation. the drug cyclosporin a (csa) has been shown to interfere with this process, allowing the escape of normally 'forbidden' t-cell clones and the appearance of autoimmune disease. recently, it has been demonstrated that immature thymocytes undergo programmed cell death (apoptosis) upon activation via the t-cell receptor. a similar phe ...20092786609
[intraoperative monitoring of cerebral function and carotid hemodynamics during carotid endarterectomy].the authors investigated the hemodynamics and monitored the cerebral function to perform the carotid endarterectomy (cea) safely. the hemodynamics were investigated by measurements of carotid arterial blood flow by an electromagnetic flow meter before and after cea. and a doppler flow meter applied directly to the carotid arteries to analyze the flow parameters such as peak frequencies (pf), mean frequencies (mf), mode frequencies (mo f) and % window. we used routinely our specially designed shu ...20092812257
[intraoperative monitoring of cerebral function and carotid hemodynamics during carotid endarterectomy].the authors investigated the hemodynamics and monitored the cerebral function to perform the carotid endarterectomy (cea) safely. the hemodynamics were investigated by measurements of carotid arterial blood flow by an electromagnetic flow meter before and after cea. and a doppler flow meter applied directly to the carotid arteries to analyze the flow parameters such as peak frequencies (pf), mean frequencies (mf), mode frequencies (mo f) and % window. we used routinely our specially designed shu ...20092812257
[left ventricular pressure-volume diagram determined by forward and backward formatting of radionuclide ventriculography and analog pressure data].pressure-volume (pv) loop is of great value for the assessment of left ventricular (lv) function, but its clinical application has been limited by methodological complexity. a new system was developed to make accurate loop with simplified procedure, and was applied to clinical and interventional study. the system constitutes of a mobile gamma camera, a poly-amplifier and a data processor (gms-550u, toshiba medical) installed in cardiac catheterization labo for simultaneous raw data handling and ...20092786583
[hydration of complementary 9-methyladenine.1-methyluracil pairs at low temperatures according to data from field mass spectrometry].the hydration of nucleotide bases of m9ade(a), m1ura(u) and a complementary pair a.u was studied by field ionization mass-spectrometry at room and low (170 k) temperatures in vacuum. enthalpies of a.u-pair formation and its monohydrate a.u(h2o) were measured using temperature dependences of association constants. from the analysis of intensities of mass-spectrum peaks, corresponding to monohydrates u(h2o), a(h2o), a.u(h2o), a.u-pair and initial components a, u, and also measured enthalpies it is ...20092742892
a preliminary study of mercury contamination in the surface soil and river sediment of the roscio district, bolivar state, venezuela.the present study constitutes a comparison of mercury in surface soil and river sediments of a contaminated and an uncontaminated area of venezuela. in the contaminated area, gold prospectors have been using mercury to separate gold from auriferous sand and rock powders for many years. the baseline level of mercury in the river sediments of the uncontaminated area (manzanares river, sucre state) was 0.06 micrograms g-1, while in the contaminated area in the roscio district of bolivar state the c ...20092727674
diverticular disease of the appendix.a retrospective study of diverticular disease of the appendix was made in 3,343 consecutive instances of appendectomies. a 2 per cent incidence of diverticular disease was found. these instances were classified into four morphologic types: 1, acute diverticulitis; 2, acute appendicitis with acute diverticulitis; 3, acute appendicitis with diverticulum, and 4, appendix with diverticulum. types 1, 2 and 3 were divided into subgroups with or without perforation. the elements of clinical behavior in ...20092909128
personality hardiness, occupational stress, and burnout in critical care nurses.personality hardiness, occupational stress, and burnout were investigated in 100 critical care nurses. hardiness was predictive of occupational stress and burnout. hierarchical multiple regressions revealed that one of the three dimensions of hardiness, commitment to work, was the only variable to account for significant amounts of variance (up to 24%) across three of four measures of burnout. the study did not provide support for the stress buffering effect of hardiness. that is, an interaction ...20092727324
elevation of c-myc protein by dna strand breakage.the intracellular level of the c-myc protein is elevated in a dose and time dependent manner by dna strand breakage. lesions introduced by either alkylating agents or gamma irradiation are capable of stimulating increased production of c-myc protein. in addition, inhibition of dna strand break rejoining maintains the level of the c-myc protein in an elevated state, whilst inhibition of dna replication does not cause an increase in c-myc protein. we conclude that chromatin perturbation via dna st ...20092687769
[nursing is my life (maria-irena nieliwódzka)]. 20092694197
environment: peculiar pigment cell neoplasm in fish.chromatophoroma in the croaker (nibea mitsukurii) showed a unique geographic distribution. the contribution of environmental chemicals to the cause of chromatophoroma in the feral croaker is considered likely on the basis of the following results in our studies. 1) chromatophoroma was induced in tank-reared n. mitsukurii by administration of certain kinds of known carcinogens such as 7,12-dimethyl-benz(a)anthracene, n-methyl-n'-nitro-n-nitrosoguanidine, and nifurpirinol. 2) local accumulation of ...20092715659
[infections with herpes viruses in gynecology and obstetrics].genital herpes is a sexually transmitted infection that is feared in particular during birth, when the virus can infect the baby during its passage through the birth canal, and lead to the death of the neonate or lasting severe morbidity. much more frequent, however, is recurrent herpes genitalis that can occur up into old age, and which is usually nothing worse than a nuisance. owing to the wide spectrum of possible symptoms and their intensity, it is not infrequently recognized either very lat ...20092680836
[image quality of various venous catheters in ultrasound under standardized conditions].seven different types of venous catheters were visualised under standardised conditions with a 5 mhz linear scanner for comparison of their respective imaging qualities. under these conditions, all catheters were readily identifiable regardless of fabric and width. any formation of loops or knots could also be visualised.20092652292
infectious potential of aerosolized particles. 20082686550
[blood cell kinetics in the spleen].the mean intrasplenic blood cell transit time (stt), splenic blood cell volume (sv) and the slow mixing splenic blood cell volume (ssv) have been measured in normal subjects and patients with congestive and infiltrative splenomegaly. the normal red cell sv was 0.47 +/- 0.14 (mean +/- sd) % of the circulating red cell volume (rcv). in patients with congestive and infiltrative splenomegaly, sv was 9.82 +/- 3.55% and 0.96 +/- 0.71% of rcv, respectively. the ssv was 69.1 +/- 8.4% of the sv in normal ...20082601044
infectious potential of aerosolized particles. 20082686550
[prostatism. routine urography]. 20082426824
saliva: 3. xerostomia--aetiology and management. 20082636197
saliva: 3. xerostomia--aetiology and management. 20082636197
[a night at a hospital: monologue by a night-duty nurse]. 20082632866
a reappraisal of the terverticillate penicillia using biochemical, physiological and morphological features. i. numerical taxonomy.three-hundred-and-forty-eight strains representing the major species of terverticillate penicillia, and including representatives of other closely and distantly related species, were included in a numerical taxonomic study. one-hundred characters were derived from morphological features, physiological and biochemical activities and sem micrographs. strains were compared by both gower's coefficient and pattern difference, and clustered using the average linkage algorithm. thirty-seven species or ...20082614375
do nurses consistently document incontinence?1. urinary incontinence is inconsistently documented on medical records of nursing home residents. 2. documentation of urinary incontinence by professional nurses may be improved by changes in organizational factors such as staffing, policy implementation, and staff education. 3. forms that employ cue words for eliminative status show more documentation of continence status than forms that have an open format. 4. evaluation of changes in nursing practice in the nursing home setting can benefit f ...20082600365
[space-occupying lesions in the gallbladder in cholecystolithiasis. freiburg gastroenterology consultation]. 20082725428
recurrent anaphylactoid reaction during caesarean section.a 28-year-old woman presented for emergency caesarean section at 31 weeks' gestation with deranged liver function and a history of recurrent anaphylactoid reactions during previous pregnancy-related anaesthetics. the anaesthetic management and outcome of this case is presented.20082774125
outrageous and beyond the bounds of decency. 20082778844
sidewinder retention sutures for closure of the abdominal wall.reported herein, a technique of sutures placement that avoids certain objections to the traditional style of retention sutures is described. it is particularly useful in patients undergoing repeated laparotomy and in patients whose wounds are closed in a layered manner and who are at high risk for dehiscence.20082525819
two cytochrome p-450 isoforms catalysing o-de-ethylation of ethoxycoumarin and ethoxyresorufin in higher plants.the o-dealkylating activities of 7-ethoxycoumarin o-de-ethylase (ecod) and 7-ethoxyresorufin o-de-ethylase (erod) have been fluorimetrically detected in microsomes prepared from manganese-induced jerusalem artichoke tubers. cytochrome p-450 dependence of the reactions was demonstrated by light-reversed co inhibition, nadph-dependence, nadh-nadph synergism and by use of specific inhibitors: antibodies to nadph-cytochrome p-450 reductase, mechanism-based inactivators and tetcyclasis. apparent km v ...20082241905
stigmatizing artifacts and their effect on personal space.examining the relationship between personal space and a stigmatizing artifact, a white cane, with 58 randomly selected subjects indicated that significantly more personal space was accorded a person with an apparent visual impairment.20082608848
[measurement of orthodontic appliance force using prototype sensors].in introductory remarks the most important biomechanical principles, which are relevant for the research, and conditions which must be satisfied presented in intraoral measuring of orthodontic forces were pointed out. first the aim of the research was defined, and then the investigation of mechanical properties of acrylics as a material for orthodontic appliances were carried out. the type of strain gauges, bonds and measuring system configurations, as well as measuring amplifiers and recording ...20082635572
differential expression of the il-2 receptor subunits, p55 and p75 on various populations of primary peripheral blood mononuclear cells.unstimulated pbl were examined for expression of il-2r subunits, il-2rp55 and il-2rp75, by two-color flow cytometric analyses using mab. nkh-1+ non-t non-b cells expressed il-2rp75 but not il-2rp55, and the il-2rp75 sites on purified nkh-1+ cells were determined to be 1630 sites/cell by binding of 125i-labeled tu27 mab specific for il-2rp75. in the cd4+ t cell population, il-2rp55+ cells were significantly detected, but little or marginally of the il-2rp75+ cells. however, il-2rp75+ cells were s ...20082584707
[clinical study of osteoporosis]. 20082614196
bites and stings. part 2. bees and vespids. 20082519523
self-injury in psychiatric in-patients.suicide and self-injury in-patients were identified on the basis of a retrospective content analysis of special incidence reports completed the preceding year at an urban state psychiatric hospital. select clinical and biodemographic variables were then examined, and in order to determine the importance of these variables in the prediction of incident severity, a multiple regression analysis was performed. schizophrenic patients were found to be significantly over-represented among both the self ...20082246100
epidemic typhus.epidemic typhus is transmitted to human beings by the body louse pediculus humanus corporis. the disease is still considered a major threat by public-health authorities, despite the efficacy of antibiotics, because poor sanitary conditions are conducive to louse proliferation. until recently, rickettsia prowazekii, the causal agent, was thought to be confined to human beings and their body lice. since 1975, r prowazekii infection in human beings has been related to contact with the flying squirr ...200818582834
genotyping rickettsia prowazekii isolates.we developed a typing method that can differentiate 8 strains of rickettsia prowazekii into 7 genotypes. this method can be used to type and trace the origin of r. prowazekii isolated from samples collected during epidemics after a bioterrorism attack.200818680662
[the role of turkish physicians in the vaccination against typhus during the years of world war i].during the years of world war i, several severe typhus epidemics were seen in erzurum and nearby cities. a total of 164 health officers, 125 of whom were physicians, struggled against the epidemic in the region but also they lost their lives due to typhus. vaccination against typhus was one of the means of fighting the epidemic. however, there were some claims that a small group of turkish physicians injected typhus-contaminated serum into armenian civilians during world war i, and that this sho ...200818697428
the genome of borrelia recurrentis, the agent of deadly louse-borne relapsing fever, is a degraded subset of tick-borne borrelia duttonii.in an effort to understand how a tick-borne pathogen adapts to the body louse, we sequenced and compared the genomes of the recurrent fever agents borrelia recurrentis and b. duttonii. the 1,242,163-1,574,910-bp fragmented genomes of b. recurrentis and b. duttonii contain a unique 23-kb linear plasmid. this linear plasmid exhibits a large polyt track within the promoter region of an intact variable large protein gene and a telomere resolvase that is unique to borrelia. the genome content is char ...200818787695
dna microarray analysis of the heat shock transcriptome of the obligate intracytoplasmic pathogen rickettsia prowazekii.here we present the first oligonucleotide dna microarray analysis of global gene expression changes in the obligate intracytoplasmic pathogen rickettsia prowazekii using temperature upshift as a model stress condition, and we describe a methodology for isolating highly purified rickettsial rna. in toto, 23 transcripts were significantly increased by temperature upshift (> or = 2.0-fold; p < 0.05), and no transcripts demonstrated reproducible decreases. array results for three heat shock-inducibl ...200818952868
infection of endothelial cells with virulent rickettsia prowazekii increases the transmigration of leukocytes.rickettsia prowazekii, the etiologic agent of epidemic typhus, infects vascular endothelium, leading to vasculitis and tissue infiltration of leukocytes. murine and human endothelial cells (ecs) were infected with r. prowazekii, including the virulent breinl strain and the attenuated madrid e strain. the transendothelial migration (tm) of murine and human peripheral blood mononuclear cells (pbmcs) across ecs infected with breinl organisms was significantly increased compared with that for uninfe ...200818171297
rickettsial diseases: from rickettsia-arthropod relationships to pathophysiology and animal models.rickettsiae cause spotted fevers and typhus-related diseases in humans. some of these diseases occur worldwide and are life-threatening, for example, epidemic typhus is still a major health problem despite the apparent efficiency of antibiotic treatment. in addition, rickettsia prowazekii, the agent of epidemic typhus, and r. rickettsii, the agent of rocky mountain spotted fever, are microorganisms that could potentially be used as bioweapons to induce panic in the population. rickettsiae are ob ...200818366341
[the epidemiology of rat louse-borne typhus]. 200818557364
typhus fever in pondicherry. 200819301703
[cultivation of the clothes lice adapted to feeding on rabbits].a race of clothes lice adapted to feeding on rabbits is kept at a laboratory longer than 50 years. for this period, more than 850 insect generations undergoing no change in a number of biological tests and morphological indices have been obtained. they have retained a high susceptibility to provacheck rickettsia infection. all infected lice die, partially with the signs of hemolytic imbibition. their rickettsial accumulation is as high as 10(5.0) id50 per insect for albino rats.200818561401
serological evidence of typhus group rickettsia in a homeless population in houston, texas.we tested sera from 176 homeless people in houston for antibodies against typhus group rickettsiae (tgr). sera from 19 homeless people were reactive to tgr antigens by elisa and ifa. two people had antibodies against rickettsia prowazekii (epidemic typhus) and the remaining 17 had antibodies against rickettsia typhi (murine typhus).200818697325
comparison of correspondence analysis methods for synonymous codon usage in bacteria.synonymous codon usage varies both between organisms and among genes within a genome, and arises due to differences in g + c content, replication strand skew, or gene expression levels. correspondence analysis (ca) is widely used to identify major sources of variation in synonymous codon usage among genes and provides a way to identify horizontally transferred or highly expressed genes. four methods of ca have been developed based on three kinds of input data: absolute codon frequency, relative ...200818940873
[the use of imaging procedures following kidney transplantation--diagnostic strategy].despite the continuously increasing number of successfully transplanted kidneys, graft and patient are still "threatened" by several postoperative complications as acute and chronic rejection, acute tubular necrosis, urologic and vascular complications and disorders caused by immunosuppressive medication. an early and safe detection of these conditions is of high clinical importance and a challenge to diagnostic imaging. all radiologic methods and nuclear medicine have their value for transplant ...20082678232
[the use of imaging procedures following kidney transplantation--diagnostic strategy].despite the continuously increasing number of successfully transplanted kidneys, graft and patient are still "threatened" by several postoperative complications as acute and chronic rejection, acute tubular necrosis, urologic and vascular complications and disorders caused by immunosuppressive medication. an early and safe detection of these conditions is of high clinical importance and a challenge to diagnostic imaging. all radiologic methods and nuclear medicine have their value for transplant ...20082678232
contrast dependence of short-range apparent motion.the apparent motion of band-pass filtered random dot kinematograms was assessed by measurements of two alternative direction discrimination performance. in the case of two-dimensional (isotropically filtered) stimuli, the results were largely independent of contrast: at michelson contrasts of 5 and 50%, near-perfect direction discrimination was obtainable for a limited range of displacements. however for one-dimensional (grating) stimuli, apparent motion seems to be highly dependent on contrast. ...20082336804
[comments on the paper by w. sauer and h. nolte. complications of 3260 hip endoprosthesis implantations under spinal anesthesia]. 20082293260
effects of estradiol and progesterone on diabetes-associated utero-ovarian atrophy in c57bl/ksj (db/db) mutant mice.the modulating effects of estradiol (e: 1 microgram/3.5 days) and progesterone (p: 2 mg/3.5 days) on the obesity and hyperinsulinemic and hyperglycemic components of the diabetes-obesity syndrome in female c57bl/ksj (db/db) mice, which includes cellular atrophy and adiposity in the reproductive tract, were examined and compared to corresponding control (+/?) parameters. all control and diabetic mice received oil (vehicle control), e, or p treatments starting at 4 weeks of age. body weight, serum ...20082686492
effects of estradiol and progesterone on diabetes-associated utero-ovarian atrophy in c57bl/ksj (db/db) mutant mice.the modulating effects of estradiol (e: 1 microgram/3.5 days) and progesterone (p: 2 mg/3.5 days) on the obesity and hyperinsulinemic and hyperglycemic components of the diabetes-obesity syndrome in female c57bl/ksj (db/db) mice, which includes cellular atrophy and adiposity in the reproductive tract, were examined and compared to corresponding control (+/?) parameters. all control and diabetic mice received oil (vehicle control), e, or p treatments starting at 4 weeks of age. body weight, serum ...20082686492
complete duodenogastric reflux: a scintigraphic sign of significant duodenal pathology.complete reflux of duodenal contents into the stomach with persistent retention on hepatobiliary scintigraphy or radionuclide gastrointestinal bleeding studies is a relatively rare occurrence. two cases of complete duodenogastric reflux are reported: one case in a patient with a perforated duodenal diverticulum and the other in a patient with an inflamed, bleeding duodenal ulcer. the finding of complete duodenogastric reflux and persistent retention in the stomach should instigate a thorough eva ...20082504893
[ki-1 large cell lymphoma with secondary xanthomatous infiltration of the lesions by chemotherapy]. 20082575882
acceptance of placebo-control trial design by progressive multiple sclerosis patients. the canadian cooperative multiple sclerosis study group. 20082648191
acceptance of placebo-control trial design by progressive multiple sclerosis patients. the canadian cooperative multiple sclerosis study group. 20082648191
[other methods of delivery]. 20082603102
the children of teenage mothers: patterns of early childbearing in two generations.twenty years after a mostly black group of baltimore women became adolescent mothers, the majority of their first-born children had not become adolescent parents, a finding that challenges the popular belief that the offspring of teenage mothers are themselves destined to become adolescent parents. almost all of the offspring had had intercourse by age 19. about half of the young women had experienced a pregnancy before that age, and approximately one-third of the young men reported having impre ...20082347409
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