Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| analysis of seroprevalence against coxiella burnetii in a sample of farm workers in western sicily. | little is known about the development of chronic q fever caused by coxiella burnetii in occupational risk groups and in the general population in italy, as well as in many countries in the world. the aim of this study was to highlight the presence of the infection in a sample of workers operating outdoors (but not directly in contact with animals), in three provinces of western sicily, in order to detect the human seroprevalence and compare the obtained data with those found in animals raised in ... | 2016 | 27007520 |
| detection of coxiella burnetii in ambient air after a large q fever outbreak. | one of the largest q fever outbreaks ever occurred in the netherlands from 2007-2010, with 25 fatalities among 4,026 notified cases. airborne dispersion of coxiella burnetii was suspected but not studied extensively at the time. we investigated temporal and spatial variation of coxiella burnetii in ambient air at residential locations in the most affected area in the netherlands (the south-east), in the year immediately following the outbreak. one-week average ambient particulate matter < 10 μm ... | 2016 | 26991094 |
| risungbinella massiliensis sp. nov., a new member of thermoactinomycetaceae isolated from human gut. | a novel filamentous bacterium, designated gd1(t), was isolated from the gut microbiota of a 38-year-old male who suffered from a coxiella burnetii vascular for which he received multiple a broad-spectrum antibiotic cocktail at the time of the stool collection. the strain was isolated as a part of culturomics study by cultivation on 5 % sheep blood agar in aerobic condition at 28 °c, after 14 days of incubation. strain gd1(t) shows 16s rrna gene sequence similarities of 98.01 % to the type strain ... | 2016 | 26984352 |
| modifications in the glycerophospholipid composition between the coxiella burnetii phase i and phase ii cells suggest an association with phase variation of the bacterium. | glycerophospholipids (gp) extracted from the coxiella burnetii strain nine mile in virulent phase i (nm i) and low virulent phase ii (nm ii) were analyzed by fourier transform ion cyclotron resonance (ft-icr) mass spectrometry (ms) that gave a superior mass resolution and mass accuracy allowing unambiguous peak recognition and precise assignment of ions. we showed that gp present in the pathogen's outer membrane underwent considerable modifications during the phase variation that might be relate ... | 2016 | 26982464 |
| treatment of an abdominal aortic aneurysm infected by coxiella burnetii using a cryopreserved allograft. | q fever is a worldwide zoonosis caused by an intracellular bacillus named coxiella burnetii (cb) and is a rare cause of vascular infections. we report a case of abdominal aortic aneurysm infected by cb with bilateral paravertebral abscesses and contiguous spondylodiscitis treated by open repair using a cryopreserved allograft and long-term antibiotic therapy by oral doxycycline and oral hydroxychloroquine for a duration of 18 months. twenty months after the operation, the patient had no infectio ... | 2016 | 26968369 |
| embolization of a large rapidly growing aortic pseudo-aneurysm not amenable to open or endovascular repair. | to report the case of a rapidly growing aortic false aneurysm because of q fever infection that was managed by embolization. | 2016 | 26968368 |
| coxiella burnetii seroprevalence and risk factors in cattle farmers and farm residents in three northeastern provinces and inner mongolia autonomous region, china. | little is known about coxiella burnetii infection among cattle farmers and farm residents in china. thus, the present study was conducted to detect the seroprevalence of c. burnetii infection and estimate associated risk factors among cattle farmers and farm residents in china. a cross-sectional study was designed, and sera of 362 people living or working on 106 cattle farms were tested for c. burnetii igg and igm antibodies by immunofluorescence assay. overall c. burnetii seroprevalence was 35. ... | 2016 | 26966688 |
| molecular identification of q fever in patients with a suspected diagnosis of dengue in brazil in 2013-2014. | q fever is an important cause of undifferentiated fever that is rarely recognized or reported in brazil. the objective of this study was to look for the presence of coxiella burnetii during a dengue fever outbreak in the municipality of itaboraí, rio de janeiro, brazil, where this bacterium had previously infected humans and domesticated animals. blood samples from clinically suspected dengue fever patients were tested by polymerase chain reaction (pcr) for c. burnetii; the dna was detected in n ... | 2016 | 26928831 |
| [q fever : a rare differential diagnosis of granulomatous disease]. | q fever is a worldwide distributed zoonotic disease with a mostly benign course, which regularly reoccurs in germany. this report is about a patient with sporadic serologically proven q fever, which also showed typical histopathological findings with nonspecific granulomatous hepatitis, usually seen in acute disease. the bone marrow biopsy revealed so-called doughnut granulomas, which are not pathognomonic but a typical finding in q fever. this case report impressively underlines that the histom ... | 2016 | 26919849 |
| comparison of pcr-electrospray ionization mass spectrometry with 16s rrna pcr and amplicon sequencing for detection of bacteria in excised heart valves. | identification of the causative pathogen of infective endocarditis (ie) is crucial for adequate management and therapy. a broad-range pcr-electrospray ionization mass spectrometry (pcr-esi-ms) technique was compared with broad-spectrum 16s rrna pcr and amplicon sequencing (16s rrna pcr) for the detection of bacterial pathogens in 40 heart valves obtained from 34 definite infective endocarditis patients according to the modified duke criteria and six nonendocarditis patients. concordance between ... | 2016 | 27629895 |
| physiological characterization of the hematophagy of ornithodoros rostratus (acari: argasidae) on live hosts. | ornithodoros rostratus is an argasid tick and its importance is based on its hematophagy and the resulting transmission of pathogens such as rickettsia rickettsii and coxiella burnetii to its vertebrate hosts. in the face of a lack of physiological studies related to hematophagy in argasid ticks, this paper aims to identify and characterize the events that occur throughout the feeding by o. rostratus on live hosts. electrical signals and alterations on the feeding site were monitored using intra ... | 2016 | 27625415 |
| q fever (coxiella burnetii) knowledge and attitudes of australian cat breeders and their husbandry practices. | a q fever outbreak in a small animal veterinary hospital, associated with a cat caesarean section, initiated a cat seroprevalence study (n = 712) that found circulating antibodies to coxiella burnetii was highest in cattery-confined breeding cats (9.3%). these findings stimulated interest about potential sources of c. burnetii infection for cats and humans associated with cats. cat breeders are potentially a group at increased risk of c. burnetii infection, and this study sought to identify pote ... | 2016 | 27621095 |
| coxiella symbionts are widespread into hard ticks. | ticks are blood-feeding arthropods and can harbor several bacteria, including the worldwide zoonotic disease q-fever agent coxiella burnetii. recent studies have reported a distinct group of coxiella mostly associated with ixodidae ticks, including the primary endosymbionts of amblyomma americanum. in the present work, a screening for coxiella infection was performed by 16s ribosomal dna (rdna) gene analyses in 293 tick samples of 15 different species sampled worldwide, including brazil, colombi ... | 2016 | 27595990 |
| coxiella burnetii (q fever) seropositivity and associated risk factors in sheep and goat farm workers in ontario, canada. | coxiella burnetii is a zoonotic bacterium that causes q fever, a potentially severe disease of humans. the objectives of this study were to determine the seroprevalence and risk factors for c. burnetii exposure in sheep and goat farm workers in ontario, canada. between august 2010 and march 2012, 172 farm workers from 78 sheep and goat farms were surveyed regarding demographics, lifestyle, farm practices, and medical history. sera from these people were collected and analyzed for q fever titers ... | 2016 | 27585364 |
| value of 18f-fdg pet/ct in diagnosing chronic q fever in patients with central vascular disease. | the aim of this study is to describe the value of 2-deoxy-2-[18f]fluoro-d-glucose positron emission tomography/computed tomography (18f-fdg pet/ct) in diagnosing chronic q fever in patients with central vascular disease and the added value of 18f-fdg pet/ct in the diagnostic combination strategy as described in the dutch consensus guideline for diagnosing chronic q fever. | 2016 | 27571945 |
| 18f-fdg pet/ct as a central tool in the shift from chronic q fever to coxiella burnetii persistent focalized infection: a consecutive case series. | because q fever is mostly diagnosed serologically, localizing a persistent focus of coxiella burnetii infection can be challenging. f-fluorodeoxyglucose positron emission tomography/computed tomography (f-fdg pet/ct) could be an interesting tool in this context.we performed a retrospective study on patients diagnosed with c burnetii infection, who had undergone f-fdg pet/ct between 2009 and 2015. when positive f-fdg pet/ct results were obtained, we tried to determine if it changed the previous d ... | 2016 | 27559944 |
| detection and risk factors of coxiella burnetii infection in dairy cattle based on bulk tank milk samples in center of iran. | infection with coxiella burnetii has a worldwide distribution in ruminants and is associated with abortions and reproductive problems in this group of animals. this study aimed to determine the prevalence of c. burnetii dna in bulk tank milk (btm) of dairy cattle herds and to identify the risk factors of infection. this cross-sectional study was conducted in spring 2015. a total of 163 btm samples from 74 commercial and 89 traditional dairy cattle herds in isfahan, iran was tested for the is1111 ... | 2016 | 27836035 |
| evaluation of qpcr and phase i and ii antibodies for detection of coxiella burnetii infection in cattle. | diagnosis of q fever in cattle is not easy due to the need to test the samples by both serological and molecular methods. aim of this study was to evaluate qpcr, and phase i and ii antibodies for detection of c. burnetii infection in cattle. a total of 187 bovine blood and vaginal swabs, and 97 milk samples, were tested. limitations of serological tests were that the available indirect enzyme linked immunosorbent assay (ielisa) could lose positive results if antibody titres were low; or phase ii ... | 2016 | 27663372 |
| use of 18f-fdg pet/ct for diagnosis of vascular graft infection with spread to sternum caused by coxiella burnetii. | 2016 | 27356964 | |
| the natural history of acute q fever: a prospective australian cohort. | a detailed description of the natural history of acute q fever, caused by infection with coxiella burnetii, aim: : to significantly increase understanding of the illness. | 2016 | 27037328 |
| coxiella burnetii avirulent nine mile phase ii induces caspase-1-dependent pyroptosis in murine peritoneal b1a b cells. | our recent study demonstrated that virulent coxiella burnetii nine mile phase i (nmi) is capable of infecting and replicating within peritoneal b1a cells and that b1a cells play an important role in host defense against c. burnetii infection in mice. however, it remains unknown if avirulent nine mile phase ii (nmii) can infect and replicate in b1a cells and whether nmi and nmii can differentially interact with b1a cells. in this study, we examined if nmi and nmii can differentially modulate host ... | 2016 | 27736781 |
| coxiella burnetii genotypes in iberian wildlife. | to investigate if coxiella burnetii, the causative agent of q fever, genotypes circulating in wildlife are associated with those infecting livestock and humans, multiple-locus variable number tandem-repeat analysis (mlva-6-marker) was carried out over c. burnetii obtained from red deer (cervus elaphus), eurasian wild boar (sus scrofa), european wild rabbit (oryctolagus cuniculus), black rat (rattus rattus), and wood mouse (apodemus sylvaticus). mlva typing was performed by using six variable loc ... | 2016 | 27216529 |
| coxiella burnetii chronic pericarditis: a case report. | coxiella burnetii is capable of causing a variety of acute and chronic infections. we present a case of pericarditis with serologically confirmed chronic c. burnetii infection. this case report emphasises the justification of serological testing for chronic c. burnetii infection in patients with prolonged or recurrent pericarditis, particularly in countries endemic for c. burnetii infection. | 2016 | 27762219 |
| analysis of coxiela burnetti dihydrofolate reductase via in silico docking with inhibitors and molecular dynamics simulation. | coxiella burnetii is a gram-negative bacterium able to infect several eukaryotic cells, mainly monocytes and macrophages. it is found widely in nature with ticks, birds, and mammals as major hosts. c. burnetii is also the biological warfare agent that causes q fever, a disease that has no vaccine or proven chemotherapy available. considering the current geopolitical context, this fact reinforces the need for discovering new treatments and molecular targets for drug design against c. burnetii. am ... | 2016 | 27726597 |
| the sero-epidemiology of coxiella burnetii in humans and cattle, western kenya: evidence from a cross-sectional study. | evidence suggests that the intracellular bacterial pathogen coxiella burnetii (which causes q fever) is widespread, with a near global distribution. while there has been increasing attention to q fever epidemiology in high-income settings, a recent systematic review highlighted significant gaps in our understanding of the prevalence, spatial distribution and risk factors for q fever infection across africa. this research aimed to provide a one health assessment of q fever epidemiology in parts o ... | 2016 | 27716804 |
| chronic q fever: a missed prosthetic valve endocarditis possibly for years. | chronic coxiella burnetii endocarditis usually develops in people with underlying heart disease and accounts for 60-70% of chronic q fever. onset is generally insidious and manifestations are atypical. the authors report a case of coxiella burnetii prosthetic valve endocarditis in a 53 years- old patient with recurrent mechanical valve dehiscence on mitral position. he lived in a rural area with sheep and goats on the surroundings. during a 9 year- period, he was submitted to three cardiac mitra ... | 2016 | 27713859 |
| vasodilator-stimulated phosphoprotein activity is required for coxiella burnetii growth in human macrophages. | coxiella burnetii is an intracellular bacterial pathogen that causes human q fever, an acute flu-like illness that can progress to chronic endocarditis and liver and bone infections. humans are typically infected by aerosol-mediated transmission, and c. burnetii initially targets alveolar macrophages wherein the pathogen replicates in a phagolysosome-like niche known as the parasitophorous vacuole (pv). c. burnetii manipulates host camp-dependent protein kinase (pka) signaling to promote pv form ... | 2016 | 27711191 |
| identification of coxiella burnetii cd8+ t-cell epitopes and delivery by attenuated listeria monocytogenes as a vaccine vector in a c57bl/6 mouse model. | coxiella burnetii is a gram-negative bacterium that causes acute and chronic q fever. because of the severe adverse effect of whole-cell vaccination, identification of immunodominant antigens of c. burnetii has become a major focus of q fever vaccine development. we hypothesized that secreted c. burnetii type iv secretion system (t4ss) effectors may represent a major class of cd8(+) t-cell antigens, owing to their cytosolic localization. twenty-nine peptides were identified that elicited robust ... | 2016 | 27703037 |
| detection of coxiella burnetii infection in a saharawi dorcas gazelle (gazella dorcas neglecta). | coxiella burnetii, the causative agent of q fever, can infect a wide range of host species, but limited information exists on the occurrence and implications of infection in wild species. this study describes a natural infection in a population of dorcas gazelles ( gazella dorcas ) from a zoo. a 9-yr-old male saharawi dorcas gazelle ( gazella dorcas neglecta) tested positive on enzyme-linked immunosorbent assay (elisa) and fecal polymerase chain reaction (pcr). despite treatment with oxytetracyc ... | 2016 | 27691954 |
| detection and genotyping of coxiella burnetii in pigs, south korea, 2014-2015. | we assessed coxiella burnetii prevalence and genotypes in pigs in south korea during 2014-2015. prevalence was low among 1,030 samples tested by elisa and immunofluorescent assay and 1,124 samples tested by pcr. despite this finding, possible transmission of c. burnetii from pigs to humans cannot be excluded. | 2016 | 27869590 |
| climate change effects on airborne pathogenic bioaerosol concentrations: a scenario analysis. | the most recent ipcc report presented further scientific evidence for global climate change in the twenty-first century. important secondary effects of climate change include those on water resource availability, agricultural yields, urban healthy living, biodiversity, ecosystems, food security, and public health. the aim of this explorative study was to determine the range of expected airborne pathogen concentrations during a single outbreak or release in a future climate compared to a historic ... | 2016 | 27890966 |
| the effector cig57 hijacks fcho-mediated vesicular trafficking to facilitate intracellular replication of coxiella burnetii. | coxiella burnetii is an intracellular bacterial pathogen that infects alveolar macrophages and replicates within a unique lysosome-derived vacuole. when coxiella is trafficked to a host cell lysosome the essential dot/icm type iv secretion system is activated allowing over 130 bacterial effector proteins to be translocated into the host cytosol. this cohort of effectors is believed to manipulate host cell functions to facilitate coxiella-containing vacuole (ccv) biogenesis and bacterial replicat ... | 2016 | 28002452 |
| seroprevalence of q fever in patients undergoing heart valve replacement surgery. | q fever, caused by the rickettsia coxiella burnetii, is a worldwide zoonotic disease with both acute and chronic manifestations. endocarditis is the principal chronic manifestation. q fever can easily be mistaken for degenerative valve disease due to its indolent presentation, the fastidious nature of the organism (routine cultures are negative), and the absence of a typical echocardiographic and macroscopic appearance for endocarditis. prosthetic valve failure, with associated morbidity and mor ... | 2016 | 27989050 |
| coxiella burnetii employs the dot/icm type iv secretion system to modulate host nf-κb/rela activation. | coxiella burnetii is the causative agent of q fever and an obligate intracellular pathogen in nature that survives and grows in a parasitophorous vacuole (pv) within eukaryotic host cells. c. burnetii promotes intracellular survival by subverting apoptotic and pro-inflammatory signaling pathways that are typically regulated by nuclear transcription factor-κb (nf-κb). we and others have demonstrated that c. burnetii nmii proteins inhibit expression of pro-inflammatory cytokines and induce express ... | 2016 | 28066723 |
| massive dispersal of coxiella burnetii among cattle across the united states. | q-fever is an underreported disease caused by the bacterium coxiella burnetii, which is highly infectious and has the ability to disperse great distances. it is a completely clonal pathogen with low genetic diversity and requires whole-genome analysis to identify discriminating features among closely related isolates. c. burnetii, and in particular one genotype (st20), is commonly found in cow's milk across the entire dairy industry of the usa. this single genotype dominance is suggestive of hos ... | 2016 | 28348863 |
| microbiological and parasitological survey of zoonotic agents in apparently healthy feral pigeons. | microbiological and parasitological investigation was carried out on a colony of feral pigeons, located in a green area near the main hospital of a central italy city. one hundred pigeons were submitted to clinical examination. cloacal swabs, grouped in pool of 4 samples, were analyzed to detect the presence of coxiella burnetii, chlamydia psittaci, chlamydophila spp. using a biomolecular procedure, while individual cloacal samples were examined for salmonella spp., campylobacter spp., and yeast ... | 2016 | 27487504 |
| seroprevalence of q fever, brucellosis, and bluetongue in selected provinces in lao people's democratic republic. | this study has determined the proportional seropositivity of two zoonotic diseases, q fever and brucellosis, and bluetongue virus (btv) which is nonzoonotic, in five provinces of lao people's democratic republic (pdr) (loungphabang, luangnumtha, xayaboury, xiengkhouang, and champasak, and vientiane province and vientiane capital). a total of 1,089 samples from buffalo, cattle, pigs, and goats were tested, with seropositivity of btv (96.7%), q fever (1.2%), and brucellosis (0.3%). the results of ... | 2016 | 27430548 |
| community-acquired pneumonia related to intracellular pathogens. | community-acquired pneumonia (cap) is associated with high rates of morbidity and mortality worldwide; the annual incidence of cap among adults in europe has ranged from 1.5 to 1.7 per 1000 population. intracellular bacteria are common causes of cap. however, there is considerable variation in the reported incidence between countries and change over time. the intracellular pathogens that are well established as causes of pneumonia are legionella pneumophila, mycoplasma pneumoniae, chlamydophila ... | 2016 | 27276986 |
| molecular evidence of vector-borne pathogens in dogs and cats and their ectoparasites in algiers, algeria. | in algeria, only limited information is currently available on the prevalence of emergent canine and feline vector-borne diseases. the aim of the present work was to detect by qpcr vector-associated bacteria in stray dogs and cats and their ectoparasites from algiers. 18/117 (15.38%) dogs and 2/107 (1.87%) cats were positive for at least one vector-borne agent. coxiella burnetii and bartonella henselae were identified in 1/117 (0.85%) dog individually. ehrlichia canis dna was detected in 17/117 ... | 2016 | 27012917 |
| absence of serological evidence of rickettsia spp., bartonella spp., ehrlichia spp. and coxiella burnetii infections in american samoa. | little is known about the epidemiology of zoonotic diseases in american samoa (pacific). a review of literature did not identify any published information on human rickettsia spp., bartonella spp., ehrlichia spp. or coxiella burnetii infections in this country. to determine the presence of these diseases, we conducted a serosurvey of american samoans. the presence of immunoglobulin g antibodies against rickettsia felis, rickettsia typhi, rickettsia conorii, c. burnetii, bartonella henselae, bart ... | 2016 | 26965788 |
| mixed methods survey of zoonotic disease awareness and practice among animal and human healthcare providers in moshi, tanzania. | zoonoses are common causes of human and livestock illness in tanzania. previous studies have shown that brucellosis, leptospirosis, and q fever account for a large proportion of human febrile illness in northern tanzania, yet they are infrequently diagnosed. we conducted this study to assess awareness and knowledge regarding selected zoonoses among healthcare providers in moshi, tanzania; to determine what diagnostic and treatment protocols are utilized; and obtain insights into contextual facto ... | 2016 | 26943334 |
| q fever is an old and neglected zoonotic disease in kenya: a systematic review. | q fever is a neglected zoonosis caused by the bacterium coxiella burnetii. the knowledge of the epidemiology of q fever in kenya is limited with no attention to control and prevention programs. the purpose of this review is to understand the situation of q fever in human and animal populations in kenya in the past 60 years, and help identify future research priorities for the country. | 2016 | 27048480 |
| molecular survey of zoonotic agents in rodents and other small mammals in croatia. | croatia is a focus for many rodent-borne zoonosis. here, we report a survey of 242 rodents and small mammals, including 43 myodes glareolus, 131 apodemus flavicollis, 53 apodemus agrarius, three apodemus sylvaticus, six sorex araneus, four microtus arvalis, one microtus agrestis, and one muscardinus avellanarius, collected at eight sites in croatia over an 8-year period. multiplex masstag polymerase chain reaction (pcr) was used for detection of borrelia, rickettsia, bartonella, babesia, ehrlich ... | 2016 | 26711522 |
| serological survey of coxiella burnetii at the wildlife-livestock interface in the eastern pyrenees, spain. | coxiella burnetii is a zoonotic bacterium that infects a wide range of animal species and causes the disease q fever. both wild and domestic ruminants may be relevant in the epidemiology of c. burnetii infection. in order to investigate the significance of the ruminant host community in the alpine and subalpine ecosystems of the eastern pyrenees, northeastern spain, in the epidemiology of q fever, a serological survey was performed on samples from 599 wild and 353 sympatric domestic ruminants. | 2016 | 27121001 |
| molecular survey on the presence of zoonotic arthropod-borne pathogens in wild red deer (cervus elaphus). | to estimate the prevalence of some zoonotic tick-borne pathogens in red deer (cervus elaphus) living in italian areas with high risk of arthropod exposure, blood samples from 60 red deer were tested by pcr for a. phagocytophilum, borrelia burgdorferi s.l., coxiella burnetii, francisella tularensis, and piroplasms. thirty-four (56.67%) animals resulted positive for one or more pathogens. in particular, 24 (40%) red deer were positive for a. phagocytophilum, 16 (26.67%) for babesia divergens, 6 (1 ... | 2016 | 27477510 |
| molecular survey on zoonotic tick-borne bacteria and chlamydiae in feral pigeons (columba livia domestica). | to determine the presence of zoonotic tick-borne bacteria in feral pigeons (columba livia domestica) from urban areas. | 2016 | 27086148 |
| seroprevalence of infectious diseases in saiga antelope (saiga tatarica tatarica) in kazakhstan 2012-2014. | 286 serum samples were collected from three sub-populations of saiga in kazakhstan (betpakdala, ustyurt and volga-ural) between 2012 and 2014, and were tested for the presence of antibodies to brucella spp., bluetongue virus, peste des petits ruminants (ppr) virus, akabane virus, schmallenberg virus, chlamydophila, toxoplasma, mycobacterium avium subspecies paratuberculosis and coxiella burnetii (q fever). seropositives to coxiella burnetii of saiga were detected and the adjusted seroprevalence ... | 2016 | 27094147 |
| chronic q fever in alberta: a case of coxiella burnetii mycotic aneurysm and concomitant vertebral osteomyelitis. | chronic q fever is a potentially life-threatening infection from the intracellular, gram-negative coxiella burnetii. it presents most commonly as endocarditis or vascular infection in people with underlying cardiac or vascular disease. we discuss a case of a 67-year-old male with coxiella burnetii vascular infection of a perirenal abdominal aortic graft. the patient had a history of an abdominal aortic aneurysm (aaa) repair 5 years earlier. he presented with a 12 × 6 × 8 cm perirenal pseudoaneur ... | 2016 | 27366178 |
| molecular epidemiological surveillance to assess emergence and re-emergence of tick-borne infections in tick samples from china evaluated by nested pcrs. | an investigation was performed to detect eight pathogens in ticks collected from grass tips or animals in the southern, central and northeast regions of china. dna samples extracted from ticks were collected from ten different locations in eight provinces of china and subjected to screening for tick-borne pathogens, including borrelia burgdorferi sensu lato, ehrlichia spp., rickettsia spp., babesia/theileria spp., ehrlichia ruminantium, coxiella burnetii, and francisella tularensis, using nested ... | 2016 | 26943995 |
| molecular detection of rickettsia, anaplasma, coxiella and francisella bacteria in ticks collected from artiodactyla in thailand. | a total of 79 ticks collected from sambar deer (cervus unicolor), barking deer (muntiacus muntjak) and wild boar (sus scrofa) were examined by pcr for the presence of rickettsia, anaplasma, coxiella, and francisella bacteria. of the 79 ticks, 13% tested positive for rickettsia, 15% tested positive for anaplasma, 4% tested positive for coxiella, and 3% tested positive for francisella. interestingly, triple infection with anaplasma, rickettsia and francisella was determined in a dermacentor auratu ... | 2016 | 26934997 |
| anaplasma marginale and theileria annulata in questing ticks from portugal. | ticks are ubiquitous arthropods and vectors of several pathogenic agents in animals and humans. monitoring questing ticks is of great importance to ascertain the occurrence of pathogens and the potential vector species, offering an insight into the risk of disease transmission in a given area. in this study 428 host-seeking ticks, belonging to nine species of ixodidae and collected from 17 of the 23 portuguese mainland subregions, were screened for several tick-borne agents with veterinary relev ... | 2016 | 27394441 |
| molecular detection and genotyping of coxiella-like endosymbionts in ticks that infest horses in south korea. | members of the genus coxiella can be transmitted from ticks to humans during contact with animals; coxiella may thus spread from the infected horses or ticks to humans. in this study, the presence of coxiella burnetii and coxiella-like endosymbionts (cle) in ticks found on infested horses was determined using pcr and genotyping. a total of 213 ticks were randomly collected from 51 horses (4-5 ticks per horse) raised on jeju island, korea, between 2009 and 2013. all ticks were morphologically ide ... | 2016 | 27792764 |
| first identification and description of rickettsioses and q fever as causes of acute febrile illness in nicaragua. | rickettsial infections and q fever present similarly to other acute febrile illnesses, but are infrequently diagnosed because of limited diagnostic tools. despite sporadic reports, rickettsial infections and q fever have not been prospectively studied in central america. | 2016 | 28036394 |
| false detection of coxiella burnetii-what is the risk? | 2016 | 27190242 | |
| multiple pathogens including potential new species in tick vectors in côte d'ivoire. | our study aimed to assess the presence of different pathogens in ticks collected in two regions in côte d'ivoire. | 2016 | 26771308 |
| the ecological niche of dermacentor marginatus in germany. | the ixodid tick dermacentor marginatus (sulzer, 1776) is endemic throughout southern europe in the range of 33-51 (°) n latitude. in germany, however, d. marginatus was exclusively reported in the rhine valley and adjacent areas. its northern distribution limit near giessen is located at the coordinates 8.32 (°) e/50.65 (°) n. particularly with regard to the causative agents of rickettsioses, tularemia, and q fever, the observed locations as well as the potential distribution of the vector d. ma ... | 2016 | 26993325 |
| atypical aetiology in patients hospitalised with community-acquired pneumonia is associated with age, gender and season; a data-analysis on four dutch cohorts. | microorganisms causing community-acquired pneumonia (cap) can be categorised into viral, typical and atypical (legionella species, coxiella burnetii, mycoplasma pneumoniae, and chlamydia species). extensive microbiological testing to identify the causative microorganism is not standardly recommended, and empiric treatment does not always cover atypical pathogens. in order to optimize epidemiologic knowledge of cap and to improve empiric antibiotic choice, we investigated whether atypical microor ... | 2016 | 27317257 |
| coxiella burnetii effector cvpb modulates phosphoinositide metabolism for optimal vacuole development. | the q fever bacterium coxiella burnetii replicates inside host cells within a large coxiella-containing vacuole (ccv) whose biogenesis relies on the dot/icm-dependent secretion of bacterial effectors. several membrane trafficking pathways contribute membranes, proteins, and lipids for ccv biogenesis. these include the endocytic and autophagy pathways, which are characterized by phosphatidylinositol 3-phosphate [pi(3)p]-positive membranes. here we show that the c. burnetii secreted effector coxie ... | 2016 | 27226300 |
| type i interferon counters or promotes coxiella burnetii replication dependent on tissue. | coxiella burnetii is an intracellular pathogen and the cause of q fever. gamma interferon (ifn-γ) is critical for host protection from infection, but a role for type i ifn in c. burnetii infection has not been determined. type i ifn supports host protection from a related pathogen, legionella pneumophila, and we hypothesized that it would be similarly protective in c. burnetii infection. in contrast to our prediction, ifn-α receptor-deficient (ifnar(-/-)) mice were protected from c. burnetii-ind ... | 2016 | 27068091 |
| complementation of arginine auxotrophy for genetic transformation of coxiella burnetii by use of a defined axenic medium. | host cell-free (axenic) culture of coxiella burnetii in acidified citrate cysteine medium-2 (accm-2) has provided important opportunities for investigating the biology of this naturally obligate intracellular pathogen and enabled the development of tools for genetic manipulation. however, accm-2 has complex nutrient sources that preclude a detailed study of nutritional factors required for c. burnetii growth. metabolic reconstruction of c. burnetii predicts that the bacterium cannot synthesize a ... | 2016 | 26969695 |
| development of an ex vivo tissue platform to study the human lung response to coxiella burnetii. | coxiella burnetii is an intracellular bacterial pathogen that causes human q fever, an acute debilitating flu-like illness that can also present as chronic endocarditis. disease typically occurs following inhalation of contaminated aerosols, resulting in an initial pulmonary infection. in human cells, c. burnetii generates a replication niche termed the parasitophorous vacuole (pv) by directing fusion with autophagosomes and lysosomes. c. burnetii requires this lysosomal environment for replicat ... | 2016 | 26902725 |
| disease burden of 32 infectious diseases in the netherlands, 2007-2011. | infectious disease burden estimates provided by a composite health measure give a balanced view of the true impact of a disease on a population, allowing the relative impact of diseases that differ in severity and mortality to be monitored over time. this article presents the first national disease burden estimates for a comprehensive set of 32 infectious diseases in the netherlands. | 2016 | 27097024 |
| coxiella burnetii dormancy in a fatal ten-year multisystem dysfunctional illness: case report. | in a previous study of a q fever outbreak in birmingham, our group identified a non-infective complex of coxiella burnetii (c.b.) antigens able to survive in the host and provoked aberrant humoral and cell-mediated immunity responses. the study led to recognition of a possible pathogenic link between c.b. infection and subsequent long-term post q fever fatigue syndrome (qfs). this report presents an unusually severe case of c.b. antigen and dna detection in post-mortem specimens from a patient w ... | 2016 | 27091026 |
| primary role for toll-like receptor-driven tumor necrosis factor rather than cytosolic immune detection in restricting coxiella burnetii phase ii replication within mouse macrophages. | coxiella burnetii replicates within permissive host cells by employing a dot/icm type iv secretion system (t4ss) to translocate effector proteins that direct the formation of a parasitophorous vacuole. c57bl/6 mouse macrophages restrict the intracellular replication of the c. burnetii. nine mile phase ii (nmii) strain. however, eliminating toll-like receptor 2 (tlr2) permits bacterial replication, indicating that the restriction of bacterial replication is immune mediated. here, we examined whet ... | 2016 | 26787725 |
| studying coxiella burnetii type iv substrates in the yeast saccharomyces cerevisiae: focus on subcellular localization and protein aggregation. | coxiella burnetii is a gram-negative obligate parasitic bacterium that causes the disease q-fever in humans. to establish its intracellular niche, it utilizes the icm/dot type ivb secretion system (t4bss) to inject protein effectors into the host cell cytoplasm. the host targets of most cognate and candidate t4bss-translocated effectors remain obscure. we used the yeast saccharomyces cerevisiae as a model to express and study six c. burnetii effectors, namely anka, ankb, ankf, cbu0077, caea and ... | 2016 | 26821324 |
| the inhibition of the apoptosis pathway by the coxiella burnetii effector protein caea requires the ek repetition motif, but is independent of survivin. | absrtact coxiella burnetii is an obligate intracellular bacterium that causes query (q) fever, a zoonotic disease. it requires a functional type iv secretion system (t4ss) which translocate bacterial effector proteins into the host cell cytoplasm and thereby facilitates bacterial replication. to date, more than 130 effector proteins have been identified, but their functions remain largely unknown. recently, we demonstrated that one of these proteins, caea (cbu1524) localized to the host cell nuc ... | 2016 | 26760129 |
| infra-red radiometry and thermography: their applications in rheumatology. | 2016 | 5085090 | |
| anti-obesity action of fenfluramine. | 2016 | 5070964 | |
| [pathogenetic mechanisms in immunological diseases]. | 2016 | 5109581 | |
| rheumatoid arthritis and malabsorption. | 2016 | 5031698 | |
| [comparative measurements of agglutination percentages with anti-rh standard]. | 2016 | 4987785 | |
| [basic principles in treating infectious diseases in the middle-aged and elderly]. | 2016 | 4757716 | |
| changes in factor xi (plasma thromboplastin antecedent) levels during pregnancy. | 2016 | 4721140 | |
| isolation of trypanosomes in reference to the progress in microbiological purification techniques. | 2016 | 4722008 | |
| the use of laboratory animals. notes for the guidance of research workers. | 2016 | 4700674 | |
| the study of cells in cerebrospinal fluid by electron microscopy. a new method. | 2016 | 4898019 | |
| [neuraminic acid and serum proteins in the blood of patients with allergic rhinitis]. | 2016 | 4918168 | |
| erythrocyte-tube wall interactions in laminar flow of blood suspensions. | 2016 | 4916741 | |
| a pedigree showing that yta is not in the lutheran blood-group system. | 2016 | 4959170 | |
| [glia impregnation in paraffin sections]. | 2016 | 4888605 | |
| electron microscopic study of tonsillar reticulosarcoma. i. features of malignancy in tumor cells. | 2016 | 4886966 | |
| on prolonged survival of massive skin allografts in mice. | 2016 | 4880326 | |
| chemical evolution and the origin of life. a comprehensive bibliography. | 2016 | 4940450 | |
| treatment of systemic sclerosis. | 2016 | 4959071 | |
| contrasting behavior patterns of mentally retarded and emotionally disturbed children. | 2016 | 4867074 | |
| avoidance of nuclear family relationships in schizophrenia. | 2016 | 4850718 | |
| community mental health centers--quantity or quality? | 2016 | 4841129 | |
| metal substitutions and inhibition of thermolysin: spectra of the cobalt enzyme. | 2016 | 4843146 | |
| pressure measurements in the long-term follow up of peripheral vascular disease. | 2016 | 4853758 | |
| [letter: the placing of physicians in catastrophe preparedness]. | 2016 | 4822316 | |
| [value of hysterosalpingography in the diagnosis of tubal endometriosis]. | 2016 | 4822290 | |
| hyperlibido. | 2016 | 4806964 | |
| observations of the chemotherapy of hookworm infection. | 2016 | 4807485 | |
| [further studies on industrial sudden deafness]. | 2016 | 4798294 | |
| photosensitive eczema. | 2016 | 4793618 | |
| x-linked retinitis pigmentosa. | 2016 | 4784907 | |
| white therapists and negro patients. | 2016 | 5042989 | |
| [marcel péan, honorary professor of the beirut faculty, 1892-1966]. | 2016 | 4866362 | |
| conditions of appearance of local response and action potential in a simple mathematical model of nerve. | 2016 | 4758110 | |
| otolaryngologic and ophthalmologic reconstructive plastic surgery. | 2016 | 4750177 |