Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| flexible bronchoscopy contribution in the approach of diagnosis and treatment of children's respiratory diseases: the experience of a unique pediatric unit in tunisia. | our study aimed at assessing the role of flexible bronchoscopy (fb) in improving diagnosis and management of children's respiratory conditions in the pediatric unit of fb, newly created and unique in tunisia. | 2016 | 27358613 |
| bacterial-viral load and the immune response in stable and exacerbated copd: significance and therapeutic prospects. | chronic obstructive pulmonary disease (copd) is characterized by persistent airflow limitation and an abnormal inflammatory response of the lung. bacteria and viruses are a major cause of copd exacerbations and may contribute to copd progression by perpetuating the inflammatory response in the airways. bacterial variety diminishes with increasing copd severity. respiratory viruses can colonize the lower respiratory tract in stable copd, altering the respiratory microbiome and facilitating second ... | 2016 | 27042037 |
| in vitro activity of gepotidacin, a novel triazaacenaphthylene bacterial topoisomerase inhibitor, against a broad spectrum of bacterial pathogens. | gepotidacin inhibits bacterial dna replication through a mode different from that of fluoroquinolones. gepotidacin and comparators were tested by broth and agar dilution against clinical isolates. the in vitro activities of gepotidacin were comparable against methicillin-susceptible and -resistant staphylococcus aureus (mssa and mrsa, respectively) isolates (mic90, 0.5 μg/ml). the gepotidacin mic90s were as follows (in micrograms per milliliter) for the indicated bacteria: streptococcus pyogenes ... | 2016 | 26729499 |
| comparative genomic analyses of the moraxella catarrhalis serosensitive and seroresistant lineages demonstrate their independent evolution. | the bacterial speciesmoraxella catarrhalishas been hypothesized as being composed of two distinct lineages (referred to as the seroresistant [sr] and serosensitive [ss]) with separate evolutionary histories based on several molecular typing methods, whereas 16s ribotyping has suggested an additional split within the ss lineage. previously, we characterized whole-genome sequences of 12 sr-lineage isolates, which revealed a relatively small supragenome when compared with other opportunistic nasoph ... | 2016 | 26912404 |
| sinus balloon dilation as treatment for acute sphenoid sinusitis with impaired vision for a child. | this paper is about sinus balloon dilatation in treatment of acute left sphenoid sinusitis with left impaired vision in a child. balloon catheter dilatation (bcd) of the sinus ostia is a new technique. it has been shown to be a minimally invasive technique to manage chronic sinusitis. however, this method is rarely used in the treatment of acute sinusitis. so far, we know of no reported cases of sinus balloon dilatation in treatment of this case, especially for children. | 2016 | 27006660 |
| respiratory microbiome of new-born infants. | the respiratory tract, once believed to be sterile, harbors diverse bacterial communities. the role of microorganisms within health and disease is slowly being unraveled. evidence points to the neonatal period as a critical time for establishing stable bacterial communities and influencing immune responses important for long-term respiratory health. this review summarizes the evidence of early airway and lung bacterial colonization and the role the microbiome has on respiratory health in the sho ... | 2016 | 26942168 |
| community-acquired moraxella catarrhalis bacteremic pneumonia: two case reports and review of the literature. | moraxella (formerly branhamella) catarrhalis was discovered at the end of the nineteenth century, and for many decades it was considered to be a harmless commensal of the upper respiratory tract. it is a gram-negative, aerobic diplococcus considered to be the third most common pathogen isolated in childhood sinusitis and otitis media and in adult chronic lower respiratory disease, as well as an etiological agent of pneumonia in immunosuppressed patients or those with chronic obstructive pulmonar ... | 2016 | 26989548 |
| the role of respiratory viruses in the etiology of bacterial pneumonia: an ecological perspective. | pneumonia is the leading cause of death among children less than 5 years old worldwide. a wide range of viral, bacterial and fungal agents can cause pneumonia: although viruses are the most common etiologic agent, the severity of clinical symptoms associated with bacterial pneumonia and increasing antibiotic resistance makes bacterial pneumonia a major public health concern. bacterial pneumonia can follow upper respiratory viral infection and complicate lower respiratory viral infection. seconda ... | 2016 | 26884414 |
| complementary and alternative medicine treatment options for otitis media: a systematic review. | otitis media (om) has numerous presentations in children. together with conventional medical therapies aimed to prevent and/or treat om, a rising number of complementary and alternative medicine (cam) treatment options can be offered. since om is common in children, parents may ask healthcare professionals about possible cam therapies. many physicians feel that their knowledge is limited regarding these therapies, and that they desire some information. therefore, we conducted a literature review ... | 2016 | 26871802 |
| composition and dynamics of the respiratory tract microbiome in intubated patients. | lower respiratory tract infection (lrti) is a major contributor to respiratory failure requiring intubation and mechanical ventilation. lrti also occurs during mechanical ventilation, increasing the morbidity and mortality of intubated patients. we sought to understand the dynamics of respiratory tract microbiota following intubation and the relationship between microbial community structure and infection. | 2016 | 26865050 |
| clinical spectrum of primary ciliary dyskinesia in childhood. | although the triad of bronchiectasis, sinusitis and situs inversus was first described by kartagener in 1933, the clinical spectrum of primary ciliary dyskinesia is still under investigation. heterotaxy defects as well as upper and lower respiratory tract symptoms are the main manifestations in childhood. it is now recognized that situs inversus is encountered in only half of patients. the first lower respiratory symptoms may be present from infancy as neonatal respiratory distress. the most com ... | 2016 | 26862502 |
| microbial yield from physiotherapy assisted sputum production in respiratory outpatients. | sputum is a key diagnostic sample for those with chronic chest conditions including chronic and allergic aspergillus-related disease, but often not obtained in clinic. the objective of this study was to evaluate physiotherapeutic interventions to obtain sputum from those not able to spontaneously produce and the subsequent microbiological result. | 2016 | 26831895 |
| randomized clinical trial of a sustained-exposure ciprofloxacin for intratympanic injection during tympanostomy tube surgery. | this exploratory clinical trial evaluated the safety and clinical activity of a novel, sustained-exposure formulation of ciprofloxacin microparticulates in poloxamer (oto-201) administered during tympanostomy tube placement in children. | 2016 | 26296929 |
| does il-17 respond to the disordered lung microbiome and contribute to the neutrophilic phenotype in asthma? | th17/il-17 plays an important role in host defense and hyperimmune responses against pathogenic bacteria accompanied by the recruitment of neutrophils. th17-associated immune response is also involved in the pathogenesis of asthma, which is known as a noninfectious allergic airway disease and has been shown to be heterogeneous. th17-associated inflammation usually contributes to the neutrophilic phenotype, which is often characterized by greater severity, airflow obstruction, and steroid resista ... | 2016 | 26941484 |
| susceptibility of urinary tract bacteria to newer antimicrobial drugs. | urinary tract infections (utis) are among the commonest types of bacterial infections. the antibiotic treatment for utis is associated with important medical and economic implications. many different microorganisms can cause utis though the most common pathogens are e. coli and members of family enterobacteriaceae. the knowledge of etiology and antibiotic resistance pattern of the organisms causing urinary tract infection is essential. the present study was undertaken to evaluate trends of antib ... | 2016 | 27275323 |
| a novel mechanism for the biogenesis of outer membrane vesicles in gram-negative bacteria. | bacterial outer membrane vesicles (omvs) have important biological roles in pathogenesis and intercellular interactions, but a general mechanism of omv formation is lacking. here we show that the vacj/yrb abc (atp-binding cassette) transport system, a proposed phospholipid transporter, is involved in omv formation. deletion or repression of vacj/yrb increases omv production in two distantly related gram-negative bacteria, haemophilus influenzae and vibrio cholerae. lipidome analyses demonstrate ... | 2016 | 26806181 |
| the vaccine candidate substrate binding protein sbp2 plays a key role in arginine uptake, which is required for growth of moraxella catarrhalis. | moraxella catarrhalis is an exclusively human pathogen that is an important cause of otitis media in children and lower respiratory tract infections in adults with chronic obstructive pulmonary disease. a vaccine to prevent m. catarrhalis infections would have an enormous global impact in reducing morbidity resulting from these infections. substrate binding protein 2 (sbp2) of an abc transporter system has recently been identified as a promising vaccine candidate antigen on the bacterial surface ... | 2016 | 26597985 |
| α/β coiled coils. | coiled coils are the best-understood protein fold, as their backbone structure can uniquely be described by parametric equations. this level of understanding has allowed their manipulation in unprecedented detail. they do not seem a likely source of surprises, yet we describe here the unexpected formation of a new type of fiber by the simple insertion of two or six residues into the underlying heptad repeat of a parallel, trimeric coiled coil. these insertions strain the supercoil to the breakin ... | 2016 | 26771248 |
| osteopontin that is elevated in the airways during copd impairs the antibacterial activity of common innate antibiotics. | bacterial infections of the respiratory tract contribute to exacerbations and disease progression in chronic obstructive pulmonary disease (copd). there is also an increased risk of invasive pneumococcal disease in copd. the underlying mechanisms are not fully understood but include impaired mucociliary clearance and structural remodeling of the airways. in addition, antimicrobial proteins that are constitutively expressed or induced during inflammatory conditions are an important part of the ai ... | 2016 | 26731746 |
| management of acute otitis media in children six months of age and older. | acute otitis media (aom) continues to be a common infection in young children. milder disease, usually due to viruses or less virulent bacteria, resolves equally quickly with or without antibiotics. a bulging tympanic membrane, especially if yellow or hemorrhagic, has a high sensitivity for aom that is likely to be bacterial in origin and is a major diagnostic criterion for aom. perforation of the tympanic membrane with purulent discharge similarly indicates a bacterial cause. immediate antibiot ... | 2016 | 26941560 |
| an independent evaluation of a novel peptide mimetic, brilacidin (pmx30063), for ocular anti-infective. | brilacidin (bri), a novel defensin mimetic, was evaluated as an ocular anti-infective. | 2016 | 26501484 |
| a new model for non-typeable haemophilus influenzae middle ear infection in the junbo mutant mouse. | acute otitis media, inflammation of the middle ear, is the most common bacterial infection in children and, as a consequence, is the most common reason for antimicrobial prescription to this age group. there is currently no effective vaccine for the principal pathogen involved, non-typeable haemophilus influenzae (nthi). the most frequently used and widely accepted experimental animal model of middle ear infection is in chinchillas, but mice and gerbils have also been used. we have established a ... | 2016 | 26611891 |
| genotypic characterization of methicillin-resistant staphylococcus aureus recovered at baseline from phase 3 pneumonia clinical trials for ceftobiprole. | baseline methicillin-resistant staphylococcus aureus (mrsa) isolates from patients with nosocomial and community-acquired pneumonia collected during phase 3 trials for ceftobiprole were characterized. eighty-four unique isolates from patients enrolled in europe (50.0%), asia-western pacific region (apac; 20.2%), north america (19.0%), latin america (8.3%), and south africa (2.4%) were included. antimicrobial susceptibility testing was performed by broth microdilution and isolates screened for pa ... | 2016 | 26230870 |
| a comprehensive review of the nasal microbiome in chronic rhinosinusitis (crs). | chronic rhinosinusitis (crs) has been known as a disease with strong infectious and inflammatory components for decades. the recent advancement in methods identifying microbes has helped implicate the airway microbiome in inflammatory respiratory diseases such as asthma and copd. such studies support a role of resident microbes in both health and disease of host tissue, especially in the case of inflammatory mucosal diseases. identifying interactive events between microbes and elements of the im ... | 2016 | 26510171 |
| clinical characteristics of the patients with bacteremia due to moraxella catarrhalis in children: a case-control study. | invasive diseases due to moraxella catarrhalis are rare in children, even in immunocompromised hosts. therefore, data regarding clinical characteristics and risk factors of such patients are limited. the aim of this study is to compare the clinical characteristics of patients with bacteremia due to moraxella catarrhalis against those with bacteremia due to streptococcus pneumoniae and haemophilus influenzae. | 2015 | 26861621 |
| clinical characteristics of the patients with bacteremia due to moraxella catarrhalis in children: a case-control study. | invasive diseases due to moraxella catarrhalis are rare in children, even in immunocompromised hosts. therefore, data regarding clinical characteristics and risk factors of such patients are limited. the aim of this study is to compare the clinical characteristics of patients with bacteremia due to moraxella catarrhalis against those with bacteremia due to streptococcus pneumoniae and haemophilus influenzae. | 2015 | 26861621 |
| a phase 1 randomized, double-blind, placebo-controlled, crossover trial of das181 (fludase®) in adult subjects with well-controlled asthma. | influenza virus (ifv) infection is associated with increased morbidity and mortality in people with underlying lung disease. treatment options for ifv are currently limited and antiviral resistance is a growing concern. das181, an inhaled antiviral with a unique mechanism of action, has shown promise in early clinical trials involving generally healthy human subjects. this study was undertaken to assess the safety and tolerability of das181 in individuals with underlying reactive airway disease. | 2015 | 26830468 |
| a phase 1 randomized, double-blind, placebo-controlled, crossover trial of das181 (fludase®) in adult subjects with well-controlled asthma. | influenza virus (ifv) infection is associated with increased morbidity and mortality in people with underlying lung disease. treatment options for ifv are currently limited and antiviral resistance is a growing concern. das181, an inhaled antiviral with a unique mechanism of action, has shown promise in early clinical trials involving generally healthy human subjects. this study was undertaken to assess the safety and tolerability of das181 in individuals with underlying reactive airway disease. | 2015 | 26830468 |
| bacterial communities vary between sinuses in chronic rhinosinusitis patients. | chronic rhinosinusitis (crs) is a common and potentially debilitating disease characterized by inflammation of the sinus mucosa for longer than 12 weeks. bacterial colonization of the sinuses and its role in the pathogenesis of this disease is an ongoing area of research. recent advances in culture-independent molecular techniques for bacterial identification have the potential to provide a more accurate and complete assessment of the sinus microbiome, however there is little concordance in resu ... | 2015 | 26834708 |
| bacterial communities vary between sinuses in chronic rhinosinusitis patients. | chronic rhinosinusitis (crs) is a common and potentially debilitating disease characterized by inflammation of the sinus mucosa for longer than 12 weeks. bacterial colonization of the sinuses and its role in the pathogenesis of this disease is an ongoing area of research. recent advances in culture-independent molecular techniques for bacterial identification have the potential to provide a more accurate and complete assessment of the sinus microbiome, however there is little concordance in resu ... | 2015 | 26834708 |
| staphylococcus epidermidis and biofilm-associated neutrophils in chronic rhinosinusitis. a pilot study. | a key role of bacterial biofilm in the pathogenesis of chronic rhinosinusitis (crs) with (crswnp) and without nasal polyps (crssnp) is commonly accepted. however, the impact of some bacterial species isolated from inflamed sinus mucosa on biofilm formation is unclear. in particular, the role of staphylococcus epidermidis as aetiological agents of crs is controversial. moreover, the effect of biofilm formation on neutrophil infiltration and activity in crswnp calls for explanation. in this study, ... | 2015 | 26765504 |
| staphylococcus epidermidis and biofilm-associated neutrophils in chronic rhinosinusitis. a pilot study. | a key role of bacterial biofilm in the pathogenesis of chronic rhinosinusitis (crs) with (crswnp) and without nasal polyps (crssnp) is commonly accepted. however, the impact of some bacterial species isolated from inflamed sinus mucosa on biofilm formation is unclear. in particular, the role of staphylococcus epidermidis as aetiological agents of crs is controversial. moreover, the effect of biofilm formation on neutrophil infiltration and activity in crswnp calls for explanation. in this study, ... | 2015 | 26765504 |
| streptococcus pneumoniae colonisation in children and adolescents with asthma: impact of the heptavalent pneumococcal conjugate vaccine and evaluation of potential effect of thirteen-valent pneumococcal conjugate vaccine. | the main aim of this study was to evaluate streptococcus pneumoniae carriage in a group of school-aged children and adolescents with asthma because these results might indicate the theoretical risk of invasive pneumococcal disease (ipd) of such patients and the potential protective efficacy of the 13-valent pneumococcal conjugate vaccine (pcv13). | 2015 | 26753924 |
| streptococcus pneumoniae colonisation in children and adolescents with asthma: impact of the heptavalent pneumococcal conjugate vaccine and evaluation of potential effect of thirteen-valent pneumococcal conjugate vaccine. | the main aim of this study was to evaluate streptococcus pneumoniae carriage in a group of school-aged children and adolescents with asthma because these results might indicate the theoretical risk of invasive pneumococcal disease (ipd) of such patients and the potential protective efficacy of the 13-valent pneumococcal conjugate vaccine (pcv13). | 2015 | 26753924 |
| clinical features of children hospitalized with influenza a and b infections during the 2012-2013 influenza season in italy. | influenza is a major public health issue worldwide. it is characterized by episodes of infection that involve hundreds of millions of people each year. since that in the seasons 2010-2011 and 2011-2012 the circulation of flub was decreasing we evaluated the clinical presentation, demographic characteristics, admitting department, and length of stay in children who contracted influenza admitted to bambino gesù children's hospital, during the 2012-2013 influenza season, with the aim to establish i ... | 2015 | 26743673 |
| clinical features of children hospitalized with influenza a and b infections during the 2012-2013 influenza season in italy. | influenza is a major public health issue worldwide. it is characterized by episodes of infection that involve hundreds of millions of people each year. since that in the seasons 2010-2011 and 2011-2012 the circulation of flub was decreasing we evaluated the clinical presentation, demographic characteristics, admitting department, and length of stay in children who contracted influenza admitted to bambino gesù children's hospital, during the 2012-2013 influenza season, with the aim to establish i ... | 2015 | 26743673 |
| multidrug-resistant neisseria gonorrhoeae isolates from nanjing, china, are sensitive to killing by a novel dna gyrase inhibitor, etx0914 (azd0914). | we tested the activity of etx0914 against 187 neisseria gonorrhoeae isolates from men with urethritis in nanjing, china, in 2013. the mic50, mic90, and mic range for etx0914 were 0.03 μg/ml, 0.06 μg/ml, and ≤0.002 to 0.125 μg/ml, respectively. all isolates were resistant to ciprofloxacin, and 36.9% (69/187) were resistant to azithromycin. of the isolates, 46.5% were penicillinase-producing n. gonorrhoeae (ppng), 36% were tetracycline-resistant n. gonorrhoeae (trng), and 13% (24 isolates) had an ... | 2015 | 26482313 |
| multidrug-resistant neisseria gonorrhoeae isolates from nanjing, china, are sensitive to killing by a novel dna gyrase inhibitor, etx0914 (azd0914). | we tested the activity of etx0914 against 187 neisseria gonorrhoeae isolates from men with urethritis in nanjing, china, in 2013. the mic50, mic90, and mic range for etx0914 were 0.03 μg/ml, 0.06 μg/ml, and ≤0.002 to 0.125 μg/ml, respectively. all isolates were resistant to ciprofloxacin, and 36.9% (69/187) were resistant to azithromycin. of the isolates, 46.5% were penicillinase-producing n. gonorrhoeae (ppng), 36% were tetracycline-resistant n. gonorrhoeae (trng), and 13% (24 isolates) had an ... | 2015 | 26482313 |
| single lung transplantation in a patient with retrospective positive cross-match. | lung transplantation is a method useful in such non-malignant end-stage parenchymal and vascular diseases as: chronic obstructive pulmonary disease (copd), idiopathic interstitial pulmonary fibrosis, cystic fibrosis, or primary pulmonary hypertension. the main aim of this procedure is to extend the patient's lifespan and quality of life. however, the availability of the operation is limited by organ access. in this paper we present the case of a 58-year-old female in the fourth stage of copd, wh ... | 2015 | 26855654 |
| detection of bacteria in middle ear effusions based on the presence of allergy: does allergy augment bacterial infection in the middle ear? | bacterial infection, eustachian tube dysfunction, allergies, and immunologic factors are major causes of otitis media with effusion (ome). however, the exact pathogenesis of ome is still unclear. this study evaluated whether allergy influences bacterial growth in middle ear effusions. | 2015 | 26714647 |
| trans-basement membrane migration of eosinophils induced by lps-stimulated neutrophils from human peripheral blood in vitro. | in the airways of severe asthmatics, an increase of neutrophils and eosinophils is often observed despite high-dose corticosteroid therapy. we previously reported that interleukin-8-stimulated neutrophils induced trans-basement membrane migration (tbm) of eosinophils, suggesting the link between neutrophils and eosinophils. concentrations of lipopolysaccharide (lps) in the airway increase in severe asthma. as neutrophils express toll-like receptor (tlr)4 and can release chemoattractants for eosi ... | 2015 | 27730145 |
| lifespan of restriction-modification systems critically affects avoidance of their recognition sites in host genomes. | avoidance of palindromic recognition sites of type ii restriction-modification (r-m) systems was shown for many r-m systems in dozens of prokaryotic genomes. however the phenomenon has not been investigated systematically for all presently available genomes and annotated r-m systems. we have studied all known recognition sites in thousands of prokaryotic genomes and found factors that influence their avoidance. | 2015 | 26689194 |
| continued high incidence of children with severe influenza a(h1n1)pdm09 admitted to paediatric intensive care units in germany during the first three post-pandemic influenza seasons, 2010/11-2012/13. | previous influenza surveillance at paediatric intensive care units (picus) in germany indicated increased incidence of picu admissions for the pandemic influenza subtype a(h1n1)pdm09. we investigated incidence and clinical characteristics of influenza in children admitted to picus during the first three post-pandemic influenza seasons, using active screening. | 2015 | 26678835 |
| bronchiectasis: a bacteriological profile. | the occurrence of bronchiectasis can involve a combination of many environmental factors, including infection. the aim of our work is to determine the bacteriological profile of bronchiectasis. this is a retrospective study of 100 patients hospitalized in between january 2010 and july 2013. the average age was 48 years with a 58% female predominance. symptomatology was by a bronchial syndrome in 90% of cases. bacteriological examination was able to isolate the microbe in 35% of cases. in our stu ... | 2015 | 27047618 |
| in vitro antimicrobial activity and effect on biofilm production of a white grape juice (vitis vinifera) extract. | background. the aim of the present study was to evaluate the antimicrobial effect of a white grape juice extract (wgje) against a range of gram-positive and gram-negative bacteria, yeasts, and the fungus aspergillus niger. wgje was also tested on the production of bacterial biofilms in vitro. results. wgje inhibited in vitro most gram-positive bacteria tested, staphylococcus aureus atcc 6538p being the most sensitive strain (mic values of 3.9 μg/ml). the effect was bactericidal at the concentrat ... | 2015 | 26770255 |
| haemophilus influenzae induces steroid-resistant inflammatory responses in copd. | chronic obstructive pulmonary disease (copd) is an inflammatory disorder partially resistant to glucocorticoids. a reduced histone deacetylase (hdac) activity has been proposed to explain this resistance. haemophilus influenzae frequently colonizes the airways of copd patients, where it enhances inflammation. the effects of haemophilus influenzae on hdac activity have not been investigated before. | 2015 | 26642881 |
| functional metagenomics of the bronchial microbiome in copd. | the course of chronic obstructive pulmonary disease (copd) is frequently aggravated by exacerbations, and changes in the composition and activity of the microbiome may be implicated in their appearance. the aim of this study was to analyse the composition and the gene content of the microbial community in bronchial secretions of copd patients in both stability and exacerbation. taxonomic data were obtained by 16s rrna gene amplification and pyrosequencing, and metabolic information through shotg ... | 2015 | 26632844 |
| putative invasive pulmonary aspergillosis in critically ill patients with chronic obstructive pulmonary disease: a matched cohort study. | patients with advanced chronic obstructive pulmonary disease (copd) are at risk for developing invasive pulmonary aspergillosis. a clinical algorithm has been validated to discriminate colonization from putative invasive pulmonary aspergillosis (pipa) in aspergillus-positive respiratory tract cultures of critically ill patients. we focused on critically ill patients with copd who met the criteria for pipa. | 2015 | 26631029 |
| mycobacterium tuberculosis infection induces hdac1-mediated suppression of il-12b gene expression in macrophages. | downregulation of host gene expression is one of the many strategies employed by intracellular pathogens such as mycobacterium tuberculosis (mtb) to survive inside the macrophages and cause disease. the underlying molecular mechanism behind the downregulation of host defense gene expression is largely unknown. in this study we explored the role of histone deacetylation in macrophages in response to infection by virulent mtb h37rv in manipulating host gene expression. we show a significant increa ... | 2015 | 26697414 |
| comparative efficacy and safety of cefixime and ciprofloxacin in the management of adults with community-acquired pneumonia in ibadan, nigeria. | initial antibiotic therapy in upper and lower respiratory tract infections is usually empirical. however, the decreasing susceptibility of respiratory pathogens to antibacterials have raised concerns about the decreasing efficacy of currently available antibiotics. | 2015 | 27162517 |
| chronic rhinosinusitis pathogenesis. | there are a variety of medical conditions associated with chronic sinonasal inflammation, including chronic rhinosinusitis (crs) and cystic fibrosis. in particular, crs can be divided into 2 major subgroups based on whether nasal polyps are present or absent. unfortunately, clinical treatment strategies for patients with chronic sinonasal inflammation are limited, in part because the underlying mechanisms contributing to disease pathology are heterogeneous and not entirely known. it is hypothesi ... | 2015 | 26654193 |
| bacterial flora in the sputum and comorbidity in patients with acute exacerbations of copd. | to determine in patients admitted with an acute exacerbation of chronic obstructive pulmonary disease (ae-copd) the association between the isolation of potential pathogens in a conventional sputum culture and comorbidities. | 2015 | 26664106 |
| parental views on acute otitis media (aom) and its therapy in children--results of an exploratory survey in german childcare facilities. | acute otitis media (aom) is one of the main reasons for medical consultation and antibiotic use during childhood. although 80% of aom cases are self-limiting, antibiotic prescription is still high, either for physician- or for parent-related factors. this study aims to identify parental knowledge about, beliefs and attitudes towards, and experiences with aom and its therapy and thus to gain insights into parents' perspectives within the german health care system. | 2015 | 26620979 |
| frequency of bacterial agents isolated from patients with chronic sinusitis in northern iran. | sinusitis is a disease with significant health problems. diagnosis of sinusitis is clinical. the golden standard for detection of microorganisms that cause sinusitis is the culture of sinus drainage discharge. | 2015 | 26652093 |
| frequency of bacterial agents isolated from patients with chronic sinusitis in northern iran. | sinusitis is a disease with significant health problems. diagnosis of sinusitis is clinical. the golden standard for detection of microorganisms that cause sinusitis is the culture of sinus drainage discharge. | 2015 | 26652093 |
| early administration of azithromycin and prevention of severe lower respiratory tract illnesses in preschool children with a history of such illnesses: a randomized clinical trial. | many preschool children develop recurrent, severe episodes of lower respiratory tract illness (lrti). although viral infections are often present, bacteria may also contribute to illness pathogenesis. strategies that effectively attenuate such episodes are needed. | 2015 | 26575060 |
| acinetobacter baumannii extracellular oxa-58 is primarily and selectively released via outer membrane vesicles after sec-dependent periplasmic translocation. | carbapenem-resistant acinetobacter baumannii (crab) shelter cohabiting carbapenem-susceptible bacteria from carbapenem killing via extracellular release of carbapenem-hydrolyzing class d β-lactamases, including oxa-58. however, the mechanism of the extracellular release of oxa-58 has not been elucidated. in silico analysis predicted oxa-58 to be translocated to the periplasm via the sec system. using cell fractionation and western blotting, oxa-58 with the signal peptide and c terminus deleted w ... | 2015 | 26369971 |
| viral infection in adults with severe acute respiratory infection in colombia. | to identify the viral aetiology in adult patients with severe acute respiratory infection (sari) admitted to sentinel surveillance institutions in bogotá in 2012. | 2015 | 26576054 |
| prevalence and molecular characterizations of enterovirus d68 among children with acute respiratory infection in china between 2012 and 2014. | ev-d68 is associated with respiratory tract infections (rtis). since its first isolation, ev-d68 has been detected sporadically. however, the us and canada have experienced outbreaks of ev-d68 infections between august and december 2014. this study aimed to investigate the molecular epidemiology and clinical characteristics of ev-d68 in chongqing, southwestern china. from january 2012 to november 2014, 1876 nasopharyngeal aspirate specimens (npas) were collected from hospitalized children with r ... | 2015 | 26568267 |
| next generation protein based streptococcus pneumoniae vaccines. | all currently available streptococcus pneumoniae (spn) vaccines have limitations due to their capsular serotype composition. both the 23-valent spn polysaccharide vaccine (ppv) and 7, 10, or 13-valent spn conjugate vaccines (pcv-7, 10, -13) are serotype-based vaccines and therefore they elicit only serotype-specific immunity. emergence of replacement spn strains expressing other serotypes has consistently occurred following introduction of capsular serotype based spn vaccines. furthermore, capsu ... | 2015 | 26539741 |
| next generation protein based streptococcus pneumoniae vaccines. | all currently available streptococcus pneumoniae (spn) vaccines have limitations due to their capsular serotype composition. both the 23-valent spn polysaccharide vaccine (ppv) and 7, 10, or 13-valent spn conjugate vaccines (pcv-7, 10, -13) are serotype-based vaccines and therefore they elicit only serotype-specific immunity. emergence of replacement spn strains expressing other serotypes has consistently occurred following introduction of capsular serotype based spn vaccines. furthermore, capsu ... | 2015 | 26539741 |
| the nutraceutical properties of ovotransferrin and its potential utilization as a functional food. | ovotransferrin or conalbumin belong to the transferrin protein family and is endowed with both iron-transfer and protective activities. in addition to its well-known antibacterial properties, ovotransferrin displays other protective roles similar to those already ascertained for the homologous mammalian lactoferrin. these additional functions, in many cases not directly related to iron binding, are also displayed by the peptides derived from partial hydrolysis of ovotransferrin, suggesting a dir ... | 2015 | 26556366 |
| high prevalence of antibiotic resistance in nasopharyngeal bacterial isolates from healthy children in rural uganda: a cross-sectional study. | in uganda, the main causes of death in children under 5 years of age are malaria and pneumonia--often due to delayed diagnosis and treatment. in preparation for a community case management intervention for pneumonia and malaria, the bacterial composition of the nasopharyngeal flora and its in vitro resistance were determined in children aged five or under to establish baseline resistance to commonly used antibiotics. | 2015 | 26305429 |
| yersinia pestis uses the ail outer membrane protein to recruit vitronectin. | yersinia pestis, the agent of plague, requires the ail (attachment invasion locus) outer membrane protein to survive in the blood and tissues of its mammalian hosts. ail is important for both attachment to host cells and for resistance to complement-dependent bacteriolysis. previous studies have shown that ail interacts with components of the extracellular matrix, including fibronectin, laminin and heparan sulfate proteoglycans, and with the complement inhibitor c4b-binding protein. here, we dem ... | 2015 | 26377177 |
| formulation of thermosensitive in situ otic gel for topical management of otitis media. | antibiotics and antiinflammatory agents are the primary and main therapeutic categories in the treatment of otitis media. one of the simpler and feasible approaches of minimizing the problem of repeated use and subsequent resistance is development of sustained release formulation. therefore, the present investigation aimed to develop a sustained release in situ gel formulation containing combination of broad spectrum antibiotic and antiinflammatory agents for the management of otits media. the p ... | 2015 | 26997706 |
| immune dysfunction in patients with chronic obstructive pulmonary disease. | chronic obstructive pulmonary disease (copd) is a complex chronic disease. chronic inflammation is the hallmark of copd, involving the interplay of a wide variety of cells in the lung microenvironment. cigarette smoke (cs) induces chronic lung inflammation and is considered a key etiological factor in the development and pathogenesis of copd. structural and inflammatory cells in the lung respond to cs exposure by releasing proinflammatory mediators that recruit additional inflammatory immune cel ... | 2015 | 26595735 |
| the sputum microbiome in chronic obstructive pulmonary disease exacerbations. | acute exacerbations of chronic obstructive pulmonary disease (copd) are thought to be associated with--and perhaps to mediate--accelerated loss of lung function in copd. although the application of culture-independent methods for detection of bacteria have shown copd to be associated with marked differences in the burden, diversity, and composition of the bronchial bacterial microbiome, few studies have examined the changes associated with community-acquired exacerbations of the disease. in a lo ... | 2015 | 26595736 |
| gram-stain-based antimicrobial selection reduces cost and overuse compared with japanese guidelines. | the gram stain has been used as an essential tool for antimicrobial stewardship in our hospital since the 1970s. the objective of this study was to clarify the difference in the targeted therapies selected based on the gram stain and simulated empirical therapies based on the antimicrobial guidelines used in japan. | 2015 | 26503359 |
| incidences and influences of device-associated healthcare-associated infections in a pediatric intensive care unit in japan: a retrospective surveillance study. | device-associated healthcare-associated infections (da-hais) are a major problem in pediatric intensive care units (picus). however, there are no data available regarding the incidences of da-hais in picus in japan and their influences on length of picu stay and mortality. the objective of this study was to investigate the incidences of three common da-hais in a picu and their influences on length of picu stay and mortality in japan. | 2015 | 26509039 |
| novel moraxella catarrhalis prophages display hyperconserved non-structural genes despite their genomic diversity. | moraxella catarrhalis is an important pathogen that often causes otitis media in children, a disease that is not currently vaccine preventable. asymptomatic colonisation of the human upper respiratory tract is common and lack of clearance by the immune system is likely due to the emergence of seroresistant genetic lineages. no active bacteriophages or prophages have been described in this species. this study was undertaken to identify and categorise prophages in m. catarrhalis, their genetic div ... | 2015 | 26497500 |
| fine particulate matter in acute exacerbation of copd. | chronic obstructive pulmonary disease (copd) is a common airway disorder. in particular, acute exacerbations of copd (aecopd) can significantly reduce pulmonary function. the majority of aecopd episodes are attributed to infections, although environmental stress also plays a role. increasing urbanization and associated air pollution, especially in developing countries, have been shown to contribute to copd pathogenesis. elevated levels of particulate matter (pm) in polluted air are strongly corr ... | 2015 | 26557095 |
| zabofloxacin versus moxifloxacin in patients with copd exacerbation: a multicenter, double-blind, double-dummy, randomized, controlled, phase iii, non-inferiority trial. | a new quinolone, zabofloxacin, has now been developed; hence, a non-inferiority trial is needed to compare this new compound with another widely used quinolone to examine its efficacy and safety for the treatment of chronic obstructive pulmonary disease (copd) exacerbations. this was a prospective, multicenter, double-blind, double-dummy, randomized, controlled, parallel-group, phase iii, non-inferiority clinical trial designed to compare oral zabofloxacin (367 mg once daily for 5 days) with mox ... | 2015 | 26543359 |
| synergy and mode of action of ceftazidime plus quercetin or luteolin on streptococcus pyogenes. | streptococcus pyogenes causes streptococcal toxic shock syndrome. the recommended therapy has been often failure through the interfering of beta-lactamase-producing bacteria (blpb). the present study was to investigate antibacterial activity, synergy, and modes of action of luteolin and quercetin using alone and plus ceftazidime against s. pyogenes. the mics of ceftazidime, luteolin, and quercetin against all s. pyogenes were 0.50, 128, and 128 µg ml(-1), respectively. a synergistic effect was e ... | 2015 | 26576195 |
| distribution of major pathogens from sputum and bronchoalveolar lavage fluid in patients with noncystic fibrosis bronchiectasis: a systematic review. | noncystic fibrosis (non-cf) bronchiectasis remains as a common health problem in asia. pathogens' distribution in airways of patients with non-cf bronchiectasis is important for doctors to make right decision. | 2015 | 26481748 |
| reduced middle ear infection with non-typeable haemophilus influenzae, but not streptococcus pneumoniae, after transition to 10-valent pneumococcal non-typeable h. influenzae protein d conjugate vaccine. | in october 2009, 7-valent pneumococcal conjugate vaccine (pcv7: prevenar(tm) pfizer) was replaced in the northern territory childhood vaccination schedule by 10-valent pneumococcal haemophilus influenzae protein d conjugate vaccine (phid-cv10; synflorix(™) glaxosmithkline vaccines). this analysis aims to determine whether the reduced prevalence of suppurative otitis media measured in the phid-cv10 era was associated with changes in nasopharyngeal (np) carriage and middle ear discharge (ed) micro ... | 2015 | 26482232 |
| evaluation of the new bd max gc real-time pcr assay, analytically and clinically as a supplementary test for the bd probetec gc qx amplified dna assay, for molecular detection of neisseria gonorrhoeae. | the new bd max gc real-time pcr assay showed high clinical and analytical sensitivity and specificity. it can be an effective and accurate supplementary test for the bd probetec gc qx amplified dna assay, which had suboptimal specificity, and might also be used for initial detection of neisseria gonorrhoeae. | 2015 | 26468501 |
| familial and microbiological contribution to the otitis-prone condition. | our group has an ongoing clinical research project investigating the immunology of the otitis-prone (op) phenotype. in light of evidence that this condition arises from underlying immunological defects, we examined our sample population of stringently defined op (sop) children suffering 3 episodes of acute otitis media within 6 months or 4 within a year for a familial association with the sop phenotype. | 2015 | 26490785 |
| atraumatic splenic rupture cases presenting with hemorrhagic shock and coagulopathy treated by splenic artery occlusion using a microballoon catheter before splenectomy. | atraumatic splenic rupture (asr) is an uncommon pathologic condition in which bleeding from the spleen occurs for a variety of nontraumatic reasons. while the current trend in traumatic splenic rupture is nonoperative management including transcatheter arterial embolization, the current recommendation for the treatment of most patients with asr is splenectomy. in this report, we describe two cases of asr presenting with hemorrhagic shock and complicated by anticoagulation therapy. in patients wi ... | 2015 | 26443017 |
| lipopolysaccharide transport to the cell surface: biosynthesis and extraction from the inner membrane. | the cell surface of most gram-negative bacteria is covered with lipopolysaccharide (lps). the network of charges and sugars provided by the dense packing of lps molecules in the outer leaflet of the outer membrane interferes with the entry of hydrophobic compounds into the cell, including many antibiotics. in addition, lps can be recognized by the immune system and plays a crucial role in many interactions between bacteria and their animal hosts. lps is synthesized in the inner membrane of gram- ... | 2015 | 26370941 |
| effectiveness of polyvalent bacterial lysate and autovaccines against upper respiratory tract bacterial colonization by potential pathogens: a randomized study. | polyvalent bacterial lysate (pbl) is an oral immunostimulating vaccine consisting of bacterial standardized lysates obtained by lysis of different strains of bacteria. autovaccines are individually prepared based on the results of smears obtained from the patient. both types of vaccine can be used to treat an ongoing chronic infection. this study sought to determine which method is more effective against nasal colonization by potential respiratory tract pathogens. | 2015 | 26434686 |
| current concepts in the pathogenesis and treatment of chronic suppurative otitis media. | otitis media (om) is an inflammation of the middle ear associated with infection. despite appropriate therapy, acute om (aom) can progress to chronic suppurative om (csom) associated with ear drum perforation and purulent discharge. the effusion prevents the middle ear ossicles from properly relaying sound vibrations from the ear drum to the oval window of the inner ear, causing conductive hearing loss. in addition, the inflammatory mediators generated during csom can penetrate into the inner ea ... | 2015 | 26248613 |
| nitric oxide production inhibition and anti-mycobacterial activity of extracts and halogenated sesquiterpenes from the brazilian red alga laurencia dendroidea j. agardh. | red algae of the genus laurencia j. v. lamouroux are a rich source of secondary metabolites with important pharmacological activities such as anti-tumoral, anti-inflammatory, anti-fungal, anti-viral, anti-leishmanial, anti-helminthic, anti-malarial, anti-trypanosomal, anti-microbial as well as anti-bacterial against mycobacterium tuberculosis. | 2015 | 27013803 |
| detection of antimicrobial activity of banana peel (musa paradisiaca l.) on porphyromonas gingivalis and aggregatibacter actinomycetemcomitans: an in vitro study. | banana is used widely because of its nutritional values. in past, there are studies that show banana plant parts, and their fruits can be used to treat the human diseases. banana peel is a part of banana fruit that also has the antibacterial activity against microorganisms but has not been studied extensively. since, there are no studies that relate the antibacterial activity of banana peel against periodontal pathogens. hence, the aim of this study is to determine the antimicrobial activity of ... | 2015 | 26681854 |
| poor memory b cell generation contributes to non-protective responses to dtap vaccine antigens in otitis-prone children. | we recently identified a cohort of children with recurrent episodes of acute otitis media (aom) who fail to generate protective antibody titres to otopathogens and several vaccine antigens. in this study we determined the antibody levels against dtap vaccine antigens, diphtheria toxoid (dt), tetanus toxoid (tt) and acellular pertussis toxoid (pt) in sera from 15 stringently defined otitis-prone (sop) children and 20 non-otitis-prone (nop) children. we found significantly lower concentrations of ... | 2015 | 26138025 |
| nitrate, nitrite and nitric oxide reductases: from the last universal common ancestor to modern bacterial pathogens. | the electrochemical gradient that ensues from the enzymatic activity of cytochromes such as nitrate reductase, nitric oxide reductase, and quinol oxidase contributes to the bioenergetics of the bacterial cell. reduction of nitrogen oxides by bacterial pathogens can, however, be uncoupled from proton translocation and biosynthesis of atp or nh4(+), but still linked to quinol and nadh oxidation. ancestral nitric oxide reductases, as well as cytochrome c oxidases and quinol bo oxidases evolved from ... | 2015 | 26426528 |
| nitrate, nitrite and nitric oxide reductases: from the last universal common ancestor to modern bacterial pathogens. | the electrochemical gradient that ensues from the enzymatic activity of cytochromes such as nitrate reductase, nitric oxide reductase, and quinol oxidase contributes to the bioenergetics of the bacterial cell. reduction of nitrogen oxides by bacterial pathogens can, however, be uncoupled from proton translocation and biosynthesis of atp or nh4(+), but still linked to quinol and nadh oxidation. ancestral nitric oxide reductases, as well as cytochrome c oxidases and quinol bo oxidases evolved from ... | 2015 | 26426528 |
| il-22 defect during streptococcus pneumoniae infection triggers exacerbation of chronic obstructive pulmonary disease. | progression of chronic obstructive pulmonary disease (copd) is linked to episodes of exacerbations caused by bacterial infections due to streptococcus pneumoniae. our objective was to identify during copd, factors of susceptibility to bacterial infections among cytokine network and their role in copd exacerbations. s. pneumoniae was used to sub-lethally challenge mice chronically exposed to air or cigarette smoke (cs) and to stimulate peripheral blood mononuclear cells (pbmc) from non-smokers, s ... | 2015 | 26870795 |
| prevention of exacerbations in patients with copd and vitamin d deficiency through vitamin d supplementation (precovid): a study protocol. | vitamin d is well known for its function in calcium homeostasis and bone mineralisation, but is increasingly studied for its potential immunomodulatory properties. vitamin d deficiency is a common problem in patients with copd. previous studies have not demonstrated a beneficial effect of vitamin d on exacerbation rate in copd patients. however, subgroup analyses suggested protective effects in vitamin d deficient patients. our objective is to assess the effect of vitamin d supplementation on ex ... | 2015 | 26399451 |
| serum antibody response to moraxella catarrhalis proteins omp cd, oppa, msp22, hag, and pila2 after nasopharyngeal colonization and acute otitis media in children. | there is no licensed vaccine for moraxella catarrhalis (mcat), which is a prominent bacterium causing acute otitis media (aom) in children and lower respiratory tract infections in adults. nasopharyngeal (np) colonization caused by respiratory bacteria results in natural immunization of the host. to identify mcat antigens as vaccine candidates, we evaluated the development of naturally induced antibodies to 5 mcat surface proteins in children 6-30 months of age during mcat np colonization and ao ... | 2015 | 26392013 |
| in vitro activity of azd0914, a novel bacterial dna gyrase/topoisomerase iv inhibitor, against clinically relevant gram-positive and fastidious gram-negative pathogens. | azd0914, a new spiropyrimidinetrione bacterial dna gyrase inhibitor with a novel mode of inhibition, has activity against bacterial species commonly cultured from patient infection specimens, including fluoroquinolone-resistant isolates. this study assessed the in vitro activity of azd0914 against key gram-positive and fastidious gram-negative clinical isolates collected globally in 2013. azd0914 demonstrated potent activity, with mic90s for azd0914 of 0.25 mg/liter against staphylococcus aureus ... | 2015 | 26195518 |
| metabolomic profiling of plasma from patients with tuberculosis by use of untargeted mass spectrometry reveals novel biomarkers for diagnosis. | although tuberculosis (tb) is a reemerging disease that affects people in developing countries and immunocompromised populations in developed countries, the current diagnostic methods are far from optimal. metabolomics is increasingly being used for studies on infectious diseases. we performed metabolome profiling of plasma samples to identify potential biomarkers for diagnosing tb. we compared the plasma metabolome profiles of tb patients (n = 46) with those of community-acquired pneumonia (cap ... | 2015 | 26378277 |
| the conserved carboxyl domain of morc, an inner membrane protein of aggregatibacter actinomycetemcomitans, is essential for membrane function. | morphogenesis protein c (morc) of aggregatibacter actinomycetemcomitans is important for maintaining the membrane morphology and integrity of the cell envelope of this oral pathogen. the morc sequence and operon organization were found to be conserved in gammaproteobacteria, based on a bioinformatic analysis of 435 sequences from representative organisms. functional conservation of morc was investigated using an a. actinomycetemcomitans morc mutant as a model system to express morc homologs from ... | 2015 | 26205976 |
| the conserved carboxyl domain of morc, an inner membrane protein of aggregatibacter actinomycetemcomitans, is essential for membrane function. | morphogenesis protein c (morc) of aggregatibacter actinomycetemcomitans is important for maintaining the membrane morphology and integrity of the cell envelope of this oral pathogen. the morc sequence and operon organization were found to be conserved in gammaproteobacteria, based on a bioinformatic analysis of 435 sequences from representative organisms. functional conservation of morc was investigated using an a. actinomycetemcomitans morc mutant as a model system to express morc homologs from ... | 2015 | 26205976 |
| oral use of streptococcus salivarius k12 in children with secretory otitis media: preliminary results of a pilot, uncontrolled study. | secretory otitis media (som) remains a common disease among children. although its cause is not yet perfectly established, the pathology, often a sequel of acute otitis media (aom), is mainly characterized by persistent fluid in the middle ear cavity. twenty-two children with a diagnosis of som were treated daily for 90 days with an oral formulation containing the oral probiotic streptococcus salivarius k12 (bactoblis(®)). after treatment, the children were evaluated for aom episodes and subject ... | 2015 | 26396541 |
| population density profiles of nasopharyngeal carriage of 5 bacterial species in pre-school children measured using quantitative pcr offer potential insights into the dynamics of transmission. | bacterial vaccines can reduce carriage rates. colonization is usually a binary endpoint. real time quantitative pcr (qpcr) can quantify bacterial dna in mucosal samples over a wide range. using culture and single-gene species-specific qpcrs for streptococcus pneumoniae (lyta), streptococcus pyogenes (ntpc), moraxella catarrhalis (ompj), haemophilus influenzae (hdp) and staphylococcus aureus (nuc) and standard curves against log-phase reference strain broth cultures we described frequency and pea ... | 2015 | 26367344 |
| population density profiles of nasopharyngeal carriage of 5 bacterial species in pre-school children measured using quantitative pcr offer potential insights into the dynamics of transmission. | bacterial vaccines can reduce carriage rates. colonization is usually a binary endpoint. real time quantitative pcr (qpcr) can quantify bacterial dna in mucosal samples over a wide range. using culture and single-gene species-specific qpcrs for streptococcus pneumoniae (lyta), streptococcus pyogenes (ntpc), moraxella catarrhalis (ompj), haemophilus influenzae (hdp) and staphylococcus aureus (nuc) and standard curves against log-phase reference strain broth cultures we described frequency and pea ... | 2015 | 26367344 |
| minimally invasive sampling method identifies differences in taxonomic richness of nasal microbiomes in young infants associated with mode of delivery. | to date, there is a limited understanding of the role of the airway microbiome in the early life development of respiratory diseases such as asthma, partly due to a lack of simple and minimally invasive sample collection methods. in order to characterize the baseline microbiome of the upper respiratory tract (urt) in infants, a comparatively non-invasive method for sampling the urt microbiome suitable for use in infants was developed. microbiome samples were collected by placing filter paper in ... | 2015 | 26370110 |
| minimally invasive sampling method identifies differences in taxonomic richness of nasal microbiomes in young infants associated with mode of delivery. | to date, there is a limited understanding of the role of the airway microbiome in the early life development of respiratory diseases such as asthma, partly due to a lack of simple and minimally invasive sample collection methods. in order to characterize the baseline microbiome of the upper respiratory tract (urt) in infants, a comparatively non-invasive method for sampling the urt microbiome suitable for use in infants was developed. microbiome samples were collected by placing filter paper in ... | 2015 | 26370110 |
| pseudomonas aeruginosa uses dihydrolipoamide dehydrogenase (lpd) to bind to the human terminal pathway regulators vitronectin and clusterin to inhibit terminal pathway complement attack. | the opportunistic human pathogen pseudomonas aeruginosa controls host innate immune and complement attack. here we identify dihydrolipoamide dehydrogenase (lpd), a 57 kda moonlighting protein, as the first p. aeruginosa protein that binds the two human terminal pathway inhibitors vitronectin and clusterin. both human regulators when bound to the bacterium inhibited effector function of the terminal complement, blocked c5b-9 deposition and protected the bacterium from complement damage. p. aerugi ... | 2015 | 26368530 |
| impaired innate copd alveolar macrophage responses and toll-like receptor-9 polymorphisms. | dysfunctional innate responses of alveolar macrophages to nontypeable haemophilus influenzae, moraxella catarrhalis and streptococcus pneumoniae contribute to morbidity in chronic obstructive pulmonary disease (copd). our earlier studies discovered impaired copd alveolar macrophage responses to toll-like receptor (tlr) ligands of nontypeable h. influenzae and provide rationale for further evaluation of tlr signaling. while the role of tlr single nucleotide polymorphisms is increasingly recognize ... | 2015 | 26361369 |