Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| characterization of carbapenem-resistant acinetobacter baumannii strains isolated from hospitalized patients in palestine. | the american centers for disease control and prevention (cdc) recognizes acinetobacter baumannii as a source of global outbreaks and epidemics especially due to its increasing resistance to commercially available antibiotics. in this study, 69 single patient multidrug resistant isolates collected from all over palestine, except gaza, were studied. all the isolates were resistant to all the β-lactam antibiotics including the carbapenems. of the 69 isolates, 82.6% were positive for blaoxa-23, 14.5 ... | 2017 | 28814955 |
| [distribution and drug resistance of pathogens at hematology department of jiangsu province from 2014 to 2015: results from a multicenter, retrospective study]. | objective: to describe the distribution and drug resistance of pathogens at hematology department of jiangsu province from 2014 to 2015 to provide reference for empirical anti-infection treatment. methods: pathogens were from hematology department of 26 tertiary hospitals in jiangsu province from 2014 to 2015. antimicrobial susceptibility testing was carried out according to a unified protocol using kirby-bauer method or agar dilution method. collection of drug susceptibility results and corresp ... | 2017 | 28810329 |
| pulmonary delivery of tea tree oil-β-cyclodextrin inclusion complexes for the treatment of fungal and bacterial pneumonia. | bacterial pneumonia is a common cause of death worldwide. tea tree oil (tto) is a potent antimicrobial natural product, which is formulated in dry powder inhalers (dpis) for the treatment of fungal and bacterial pneumonia. | 2017 | 28809447 |
| development and use of personalized bacteriophage-based therapeutic cocktails to treat a patient with a disseminated resistant acinetobacter baumannii infection. | widespread antibiotic use in clinical medicine and the livestock industry has contributed to the global spread of multidrug-resistant (mdr) bacterial pathogens, including acinetobacter baumannii we report on a method used to produce a personalized bacteriophage-based therapeutic treatment for a 68-year old diabetic patient with necrotizing pancreatitis complicated by a mdr a. baumannii infection. despite multiple antibiotic courses and efforts at percutaneous drainage of a pancreatic pseudocyst, ... | 2017 | 28807909 |
| activity of the β-lactamase inhibitor ln-1-255 against carbapenem-hydrolyzing class d β-lactamases from acinetobacter baumannii. | the number of infections caused by gram-negative pathogens carrying carbapenemases is increasing, and the group of carbapenem-hydrolyzing class d β-lactamases (chdls) is especially problematic. several clinically important chdls have been identified in a. baumannii, including oxa-23, oxa-24/40, oxa-58, oxa-143, oxa-235, and the chromosomally encoded oxa-51. the selection and dissemination of carbapenem-resistant a. baumannii strains constitutes a serious global threat. carbapenems have been succ ... | 2017 | 28807908 |
| conessine as a novel inhibitor of multidrug efflux pump systems in pseudomonas aeruginosa. | holarrhena antidysenterica has been employed as an ethnobotanical plant for the treatment of dysentery, diarrhoea, fever, and bacterial infections. biological activities of the principle compound, conessine including anti-diarrhoea and anti-plasmodial effects were documented. our previous study reported potency of holarrhena antidysenterica extract and conessine as resistance modifying agents against extensively drug-resistant acinetobacter baumannii. this study aimed to investigate (i) whether ... | 2017 | 28806947 |
| integron-mediated antibiotic resistance in acinetobacter baumannii isolated from intensive care unit patients, babol, north of iran. | we investigated the integron types and their relation with antibiotic resistance among a. baumannii isolates collected from intensive care unit patients, babol, north of iran. | 2017 | 28804720 |
| bacterial infections post-living-donor liver transplantation in egyptian hepatitis c virus-cirrhotic patients: a single-center study. | to determine risk factors, causative organisms and antimicrobial resistance of bacterial infections following living-donor liver transplantation (ldlt) in cirrhotic patients. | 2017 | 28804572 |
| efficacy of radiant catalytic ionization to reduce bacterial populations in air and on different surfaces. | air contamination by biological agents is often observed in medical or veterinary facilities and industrial plants. bioaerosols may sediment and pose the surface contamination. microorganisms present on them may become a source of infections among humans and food contamination. this study determined the use of oxidative gases, including ozone and peroxide, generated by the radiant catalytic ionization (rci) cell for the inactivation of acinetobacter baumannii, escherichia coli, enterococcus faec ... | 2017 | 28803189 |
| mouse models of acinetobacter baumannii infection. | this unit describes basic protocols for infecting mice through intranasal and intraperitoneal routes with acinetobacter baumannii to induce associated pneumonia and sepsis, the two most common manifestations of clinical infections with this pathogen. by selecting the appropriate protocols and bacterial strains of different virulence, these mouse models provide an opportunity to study the infection pathogenesis and host-immune responses, and to evaluate the efficacies of prophylactic and therapeu ... | 2017 | 28800159 |
| synergy and mechanism of action of α-mangostin and ceftazidime against ceftazidime-resistant acinetobacter baumannii. | to address the resistance of acinetobacter baumannii to β-lactam antibiotics, combination therapy between different antibiotic classes is increasingly used. the antibacterial activity of α-mangostin (amt) alone or in combination with ceftazidime (ctz) was investigated against ceftazidime-resistant a. baumannii dmst 45378 (crab). initial screening showed that a. baumannii strains possessed ampc β-lactamase (ampc), extended-spectrum beta-lactamase (esbl) and metallo-β-lactamases (mbl). minimum inh ... | 2017 | 28799218 |
| virulence profiles and innate immune responses against highly lethal, multidrug-resistant nosocomial isolates of acinetobacter baumannii from a tertiary care hospital in mexico. | virulence profiles and innate immune responses were studied in acinetobacter baumannii from nosocomial infections collected over one year in a tertiary care hospital in mexico. a. baumannii were identified by vitek 2 system followed by susceptibility tests. carbapenemase genes, active efflux mechanism to imipenem and meropenem and outer membrane proteins profile were analyzed to evaluate their role on the activity of carbapenem resistance. all isolates were genotyped by pulsed field gel electrop ... | 2017 | 28797068 |
| biosurfactant and enzyme mediated crude oil degradation by pseudomonas stutzeri na3 and acinetobacter baumannii mn3. | the present study focuses on the optimization of biosurfactant (bs) production using two potential biosurfactant producer pseudomonas stutzeri na3 and acinetobacter baumannii mn3 and role of enzymes in the biodegradation of crude oil. the optimal conditions for p. stutzeri na3 and a. baumannii mn3 for biodegradation were ph of 8 and 7; temperature of 30 and 40 °c, respectively. p. stutzeri na3 and a. baumannii mn3 produced 3.81 and 4.68 g/l of bs, respectively. gas chromatography mass spectromet ... | 2017 | 28794933 |
| decontamination of hospital surfaces with multijet cold plasma: a method to enhance infection prevention and control? | objective to evaluate the efficacy of a multijet cold-plasma system and its efficacy in decontaminating 2 surfaces commonly found in hospitals design an in vitro study of common causes of healthcare-acquired infection methods log10 9 cultures of methicillin-resistant staphylococcus aureus, vancomycin-resistant enterococci, extended spectrum β-lactamase-producing escherichia coli, and acinetobacter baumannii were applied to 5-cm2 sections of stainless steel and mattress. human serum albumin (hsa) ... | 2017 | 28793943 |
| device-associated healthcare-associated infections (da-hai) and the caveat of multiresistance in a multidisciplinary intensive care unit. | device-associated healthcare-associated infections (da-hai), including ventilator-associated pneumonia (vap), central-line-associated blood stream infection (clabsi), and catheter-related urinary tract infection (cauti), are considered as principal contributors to healthcare hazard and threat to patient safety as they can cause prolonged hospital stay, sepsis, and mortality in the icu. the study intends to characterize da-hai in a tertiary care multidisciplinary icu of a teaching hospital in eas ... | 2017 | 28790779 |
| [the reliability of using impenem, meropenem, cefoperazone-sulbactam and piperacillin-tazobactam to treat nosocomial gram-negative bacterial infections with monte carlo simulation]. | objective: to evaluate the reliability of using imipenem, meropenem, cefoperazone-sulbactam, piperacillin-tazobactam in the treatment of hospital-acquired gram-negative bacterial infections with monte carlo simulation(mcs). methods: the mic of the four agents collected from hospital-acquired infections were detected in accordance with broth dilution method of clinical and laboratory standard institute (clsi). mcs were conducted with mics and the pharmacokinetics parameters of the four agents bas ... | 2017 | 28789493 |
| bioprospecting marine actinomycetes for multidrug-resistant pathogen control from rameswaram coastal area, tamil nadu, india. | a potent streptomyces bacillaris strain ram25c4 was isolated for controlling methicillin-resistant staphylococcus aureus and multidrug-resistant bacteria such as staphylococcus aureus, acinetobacter baumannii, and pseudomonas aeruginosa. a total of 131 actinomycetes were isolated from the rameswaram coastal region, tamil nadu, india. among 131 actinomycetes, maximum number of actinomycetes (55%) isolated at the distance of 3-6 m from seashore. out of 131 actinomycetes, 85% of the actinomycetes e ... | 2017 | 28785779 |
| evaluation of photodynamic therapy effect along with colistin on pandrug-resistant acinetobacter baumannii. | pandrug-resistant acinetobacter baumannii (pdrab) are including colistin resistant starins (corab) which cause infections potentially untreatable infections. recently, incidence of these strains are increasing worldwide. therefore, new approaches, methods and strategies are urgently needed for treatment and eradication of infections due to pdrab. so the aim of this study was to evaluate the efficacy of photodynamic therapy (pdt) in combination treatment with colistin against pdrab. | 2017 | 28785129 |
| amino acid profiling and antimicrobial activity of cucurbita moschata and lagenaria siceraria seed protein hydrolysates. | cucurbita moschata and lagenaria siceraria seed proteins were extracted and hydrolysed with trypsin in order to recover antibacterial peptides. amino acid content and molecular weight distribution were estimated to justify their co-relationship with antimicrobial activity. antimicrobial activities of c. moschata and l. siceraria seed protein hydrolysates against three gram-negative bacteria and two gram-positive bacteria were evaluated. seed protein hydrolysates of both of these plants have sign ... | 2017 | 28783965 |
| molecular epidemiology of carbapenem-resistant acinetobacter baumannii in a tertiary care hospital in egypt: clonal spread of blaoxa-23. | of great concern is the increased frequency of carbapenem-resistant acinetobacter baumannii (crab) causing healthcare-associated infections. different classes of β-lactamases are involved in this resistance through hydrolyzing carbapenems. multilocus sequence typing (mlst) has been applied successfully for characterizing different varieties of bacterial pathogens epidemiologically. in the present study, we aimed to type and characterize the resistance profile of clinical isolates of crab causing ... | 2017 | 28783427 |
| frequency of class 1 integron and genetic diversity of acinetobacter baumannii isolated from medical centers in kermanshah. | acinetobacter baumannii has emerged as an important pathogen in hospital and environment that can acquire transport element and antibiotic-resistant genes. the aim of this study was to determine the resistances to different antibiotics, frequency of class 1 integron in a. baumannii and then molecular typing for a. baumannii isolated from intensive care unit (icu). | 2017 | 28781486 |
| antibacterial activity of exogenous glutathione and its synergism on antibiotics sensitize carbapenem-associated multidrug resistant clinical isolates of acinetobacter baumannii. | a major clinical impact of a. baumannii is hospital-acquired infections including ventilator-associated pneumonia. the treatment of this pathogen is often difficult due to its innate and acquired resistance to almost all commercially available antibiotics. infections with carbapenem-associated multidrug resistant a. baumannii is the most problematic. glutathione is a tripeptide thiol-antioxidant and antibacterial activity of exogenous glutathione was reported in some bacteria. however, clinical ... | 2017 | 28781060 |
| acinetobacter baumannii virulence is enhanced by the combined presence of virulence factors genes phospholipase c (plcn) and elastase (lasb). | the ability of multidrug resistance acinetobacter baumannii to persist in any circumstances regard to the acquisition of many virulence factors genes and antibiotic resistance genes is major concern in the hospitals environments. in this study, thirty a. baumannii isolates were collected from blood infections from hospitalized patients were subjected to screening for virulence factors genes plcn and lasb by conventional pcr. the pathogenicity of representative isolates bearing these gene were te ... | 2017 | 28780324 |
| aortic root abscess caused by multidrug-resistant acinetobacter baumannii and treated with medical therapy only: a case report. | 2017 | 28778594 | |
| methylation, crystallization and sad phasing of the csu pilus csuc-csue chaperone-adhesin subunit pre-assembly complex from acinetobacter baumannii. | acinetobacter baumannii is one of the most difficult gram-negative bacteria to control and treat. this pathogen forms biofilms on hospital surfaces and medical devices using csu pili assembled via the archaic chaperone-usher pathway. to uncover the mechanism of bacterial attachment to abiotic surfaces, it was aimed to determine the crystal structure of the pilus tip adhesin csue. the csuc-csue chaperone-subunit pre-assembly complex was purified from the periplasm of escherichia coli overexpressi ... | 2017 | 28777087 |
| molecular epidemiology of multidrug-resistant clinical isolates of acinetobacter baumannii : a 10-year analysis in a large tertiary care university hospital in central europe with international admissions. | over the last 10 years, multidrug resistant acinetobacter baumannii has been spreading worldwide as emerging microorganisms that negatively impact on the outcome of in-hospital patients. | 2017 | 28776101 |
| sensitivity of levofloxacin in combination with ampicillin-sulbactam and tigecycline against multidrug-resistant acinetobacter baumannii. | the selection of alternative treatment options with antibiotic combinations may be used for successful managing of multidrug-resistant acinetobacter baumannii. the aim of this study was to determine the synergistic effects of ampicillin-sulbactam combined with either levofloxacin or tigecycline against mdr a. baumannii. | 2017 | 28775819 |
| biofilm formation and antibiotic susceptibility in dispersed cells versus planktonic cells from clinical, industry and environmental origins. | we examined the cell-surface physicochemical properties, the biofilm formation capability and the antibiotic susceptibility in dispersed cells (from an artificial biofilm of alginate beads) and compared with their planktonic (free-swimming) counterparts. the strains used were from different origins, such as clinical (acinetobacter baumannii ab4), cosmetic industry (klebsiella oxytoca eu213, pseudomonas aeruginosa eu190), and environmental (halomonas venusta mat28). in general, dispersed cells ad ... | 2017 | 28770446 |
| biosynthesized silver nanoparticles: are they effective antimicrobials? | silver nanoparticles (agnps) are increasingly being used in medical applications. therefore, cost effective and green methods for generating agnps are required. | 2017 | 28767978 |
| a case report of intraventricular tigecycline therapy for intracranial infection with extremely drug resistant acinetobacter baumannii. | intracranial infection with acinetobacter baumannii is a tough problem due to the presence of multiresistance and drugs poor penetration through the blood brain barrier (bbb). tigecycline is effective to cure a baumannii, but it can only be used intravenously which is also difficult to pass bbb. so, it will be a breakthrough if intraventricular (ivt) tigecycline is used in the clinical therapy. however, this treatment has been reported quite rarely until now. | 2017 | 28767605 |
| [analysis of drug resistance of acinetobacter baumannii in wound of children with traffic injury and its relationship with antibiotic use]. | objective: to know the drug resistance of acinetobacter baumannii (ab) in wound of children with traffic injury and its relationship with antibiotic use. methods: wound exudate of 226 children with traffic injury admitted to our unit from january 2010 to december 2015 were collected. api bacteria identification panels and fully automatic microbiological identification system were used to identify pathogens. kirby-bauer paper disk diffusion method was used to detect the drug resistance of pathoge ... | 2017 | 28763905 |
| global assessment of small rnas reveals a non-coding transcript involved in biofilm formation and attachment in acinetobacter baumannii atcc 17978. | many strains of acinetobacter baumannii have been described as being able to form biofilm. small non-coding rnas (srnas) control gene expression in many regulatory circuits in bacteria. the aim of the present work was to provide a global description of the srnas produced both by planktonic and biofilm-associated (sessile) cells of a. baumannii atcc 17978, and to compare the corresponding gene expression profiles to identify srnas molecules associated to biofilm formation and virulence. srna was ... | 2017 | 28763494 |
| antibiotic susceptibility profiles of non-fermenting gram-negative bacilli at a tertiary care hospital in patiala, india. | non-fermenting gram-negative bacilli (nfgnb) have emerged as a major cause of healthcare-associated infections and are innately resistant to many antibiotics. | 2017 | 28762368 |
| antimicrobial activities of widely consumed herbal teas, alone or in combination with antibiotics: an in vitro study. | because of increasing antibiotic resistance, herbal teas are the most popular natural alternatives for the treatment of infectious diseases, and are currently gaining more importance. we examined the antimicrobial activities of 31 herbal teas both alone and in combination with antibiotics or antifungals against some standard and clinical isolates of pseudomonas aeruginosa, acinetobacter baumannii, escherichia coli, klebsiella pneumoniae, enterococcus faecalis, methicillin susceptible/resistant s ... | 2017 | 28761777 |
| a short d-enantiomeric antimicrobial peptide with potent immunomodulatory and antibiofilm activity against multidrug-resistant pseudomonas aeruginosa and acinetobacter baumannii. | antimicrobial peptides (amps) represent a promising therapeutic alternative for the treatment of antibiotic-resistant bacterial infections. the present study investigates the antimicrobial activity of new, rationally-designed derivatives of a short α-helical peptide, rr. from the peptides designed, rr4 and its d-enantiomer, d-rr4, emerged as the most potent analogues with a more than 32-fold improvement in antimicrobial activity observed against multidrug-resistant strains of pseudomonas aerugin ... | 2017 | 28761101 |
| caspase-11 plays a protective role in pulmonary a. baumannii infection. | activation of caspase-11 by some gram negative bacteria triggers caspase-1/il-1β pathway independent of canonical inflammasomes. acinetobacter baumannii (a. baumannii) are gram negative, conditional pathogenic bacteria, which can lead to severe pulmonary infection in hospitalized patients. a. baumannii were revealed to activate canonical and noncanonical inflammasome pathway in bone marrow-derived macrophages (bmdms). pulmonary infection of caspase-11(-/-) mice with a. baumannii showed that casp ... | 2017 | 28760936 |
| antibacterial activity of human simulated epithelial lining fluid concentrations of amikacin inhale alone and in combination with meropenem against acinetobacter baumannii. | acinetobacter baumannii(acbn) is a mdr organism causing pneumonia in ventilated patients. high mics often result in insufficient lung exposures, thus poor outcomes have been observed with parenteral antimicrobials. amikacin inhale(amk-i), is a drug-device combination of amikacin and a pulmonary drug delivery system device. we aimed to describe the pharmacodynamic profile of human simulated epithelial lining fluid(elf) exposures of amk-i and intravenous meropenem alone and in combination against ... | 2017 | 28758820 |
| cluster-distinguishing genotypic and phenotypic diversity of carbapenem-resistant gram-negative bacteria in solid-organ transplantation patients: a comparative study. | solid-organ transplant recipients may display high rates of colonization and/or infection by multidrug-resistant bacteria. we analysed and compared the phenotypic and genotypic diversity of carbapenem-resistant (cr) strains of klebsiella pneumoniae, pseudomonas aeruginosa and acinetobacter baumannii isolated from patients in the solid organ transplantation department of our hospital. | 2017 | 28758635 |
| risk factors and predictors of carbapenem-resistant pseudomonas aeruginosa and acinetobacter baumannii mortality in critically ill bacteraemic patients over a 6-year period (2010-15): antibiotics do matter. | acinetobacter baumannii and pseudomonas aeruginosa provoke serious infections, especially in intensive care unit (icu) patients. | 2017 | 28758623 |
| the causes of post-operative meningitis: the comparison of gram-negative and gram-positive pathogens. | in this study, we aim to determine the microbiological etiology in critically ill neurosurgical patients with nosocomial meningitis (nm) and show the impact of gram-negative rods and differences of patient's characteristics, clinical and prognostic measures between gram-negative and gram-positive meningitis. | 2017 | 28758186 |
| acinetobacter baumannii lipopolysaccharide influences adipokine expression in 3t3-l1 adipocytes. | acinetobacter baumannii is one of the most important nosocomial opportunistic pathogen worldwide. in addition, obesity has been associated with an increased risk of nosocomial infection, suggesting that there may be an association between a. baumannii and white adipose tissue. however, the effects of a. baumannii on adipocytes have not been well studied at the molecular level. here, we investigated the potential role of a. baumannii-derived lipopolysaccharides (lps) as signaling molecules that a ... | 2017 | 28757686 |
| incidence, risk factors and outcome of multi-drug resistant acinetobacter baumannii acquisition during an outbreak in a burns unit. | multi-drug resistant acinetobacter baumannii (mr-ab) can cause outbreaks in a burns unit (bu). we aimed to study the incidence, risk factors and outcome of mr-ab colonization during an outbreak. | 2017 | 28751010 |
| polymyxins for cns infections: pharmacology and neurotoxicity. | central nervous system (cns) infections caused by multi-drug resistant (mdr) gram-negative bacteria present a major health and economic burden worldwide. due to the nearly empty antibiotic discovery pipeline, polymyxins (i.e. polymyxin b and colistin) are used as the last-line therapy against gram-negative 'superbugs' when all other treatment modalities have failed. the treatment of cns infections due to multi-drug resistant gram-negative bacteria is problematic and associated with high mortalit ... | 2017 | 28750947 |
| stability of bacteriophages in burn wound care products. | bacteriophages could be used along with burn wound care products to enhance antimicrobial pressure during treatment. however, some of the components of the topical antimicrobials that are traditionally used for the prevention and treatment of burn wound infection might affect the activity of phages. therefore, it is imperative to determine the counteraction of therapeutic phage preparations by burn wound care products before application in patients. five phages, representatives of two morphologi ... | 2017 | 28750102 |
| occurrence of the mcr-1 colistin resistance gene and other clinically relevant antibiotic resistance genes in microbial populations at different municipal wastewater treatment plants in germany. | seven wastewater treatment plants (wwtps) with different population equivalents and catchment areas were screened for the prevalence of the colistin resistance gene mcr-1 mediating resistance against last resort antibiotic polymyxin e. the abundance of the plasmid-associated mcr-1 gene in total microbial populations during water treatment processes was quantitatively analyzed by qpcr analyses. the presence of the colistin resistance gene was documented for all of the influent wastewater samples ... | 2017 | 28744270 |
| phenotype microarray analysis of the aders two-component system in acinetobacter baumannii. | acinetobacter baumannii is a nosocomial pathogen capable of resistance to multiple antimicrobials. the aders two-component system (tcs) is associated with antimicrobial resistance by controlling the adeabc efflux pump. to elucidate modulation by aders, we made an a. baumannii mutant lacking the aders tcs and characterized it using phenotype microarray (pm) analysis. after disrupting the aders operon, lower expression of adeabc efflux pump was observed in the mutant strain. pm analysis showed tha ... | 2017 | 28741095 |
| evolution of acinetobacter baumannii in vivo: international clone ii, more resistance to ceftazidime, mutation in ptk. | acinetobacter baumannii is an important nosocomial pathogen worldwide. a more comprehensive understanding of the within-host genomic evolution of a. baumannii would provide a molecule basis for improving treatment of a. baumannii infection. to understand the evolutionary mechanism facilitating a. baumannii survived in human body, we here reported the genomic analysis of a. baumannii isolated sampled from chinese patients. we used whole-genome sequence of a. baumannii isolates from the same patie ... | 2017 | 28740486 |
| clinical antibiotic-resistant acinetobacter baumannii strains with higher susceptibility to environmental phages than antibiotic-sensitive strains. | antibiotic-resistant acinetobacter baumannii is associated with nosocomial infections worldwide. here, we used clinically isolated a. baumannii strains as models to demonstrate whether antibiotic resistance is correlated with an increased susceptibility to bacteriophages. in this study, 24 active phages capable of infecting a. baumannii were isolated from various environments, and the susceptibilities of both antibiotic-sensitive and antibiotic-resistant strains of a. baumannii to different phag ... | 2017 | 28740225 |
| contribution of tetb efflux pump on minocycline susceptibility among carbapenem-resistant acinetobacter baumannii. | minocycline, a semi-synthetic tetracycline developed in the 1970s, has become an important treatment option against mdr a. baumannii infections, particularly those caused by carbapenem-resistant strains (1).…. | 2017 | 28739789 |
| emergence of different acinetobacter baumannii clones in a croatian hospital and correlation with antibiotic susceptibility. | during routine diagnostic laboratory work, the clinical microbiologist observed an increase of acinetobacter baumannii isolates with three different carbapenem susceptibility patterns: susceptible, intermediate and resistant. isolates belonging to the same carbapenem susceptibility phenotype exhibited identical susceptibility/resistance patterns to non-β-lactam antibiotics. this prompted us to analyse the mechanisms of carbapenem-resistance and the molecular epidemiology of the isolates. a total ... | 2017 | 28735048 |
| management of an acinetobacter baumannii outbreak in an intensive care unit. | acinetobacter baumannii is a ubiquitous pathogen resistant to desiccation and responsible for healthcare-associated infections (hai), especially in intensive care units (icu) where it is responsible for 5-10% of hais. an a. baumannii outbreak occurred in the icu of the university hospital of angers, france. | 2017 | 28734630 |
| osmotic compounds enhance antibiotic efficacy against acinetobacter baumannii biofilm communities. | biofilm-associated infections are a clinical challenge in part because a hydrated matrix protects the bacterial community from antibiotics. herein, we evaluated how different osmotic compounds [maltodextrin, sucrose and polyethylene glycol (peg)] enhance antibiotic efficacy against acinetobacter baumannii biofilm communities. established test-tube biofilms (24 h, strain atcc 17978) were treated with osmotic compounds in the presence or absence of 10x the minimum inhibitory concentration of diffe ... | 2017 | 28733283 |
| desiccation and ethanol resistances of multidrug resistant acinetobacter baumannii embedded in biofilm: the favorable antiseptic efficacy of combination chlorhexidine gluconate and ethanol. | globally, multidrug-resistant acinetobacter baumannii (mdrab) has emerged as an important pathogen in nosocomial outbreaks. this study aimed to investigate the correlation between the biofilm formation and survival of mdrabs, and to investigate the antiseptic efficacy of hand sanitizers for the mdrabs, embedded with biofilm (mdrab-bs). | 2017 | 28732564 |
| antimicrobial efficacy and synergy of metal ions against enterococcus faecium, klebsiella pneumoniae and acinetobacter baumannii in planktonic and biofilm phenotypes. | the effects of metal ion solutions (silver, copper, platinum, gold and palladium) were determined individually and in combination against enterococcus faecium, acinetobacter baumannii and klebsiella pneumoniae. platinum, gold and palladium showed the greatest antimicrobial efficacy in zone of inhibition (zoi) assays. when tested in combinations using zoi assays, gold/platinum, gold/palladium and platinum/palladium were indicative of synergy. microbial inhibitory concentration demonstrated platin ... | 2017 | 28724953 |
| molecular characterization and genetic relatedness of clinically acinetobacter baumanii isolates conferring increased resistance to the first and second generations of tetracyclines in iran. | the increasing resistance of acinetobacter baumannii to antibiotics has recently been regarded as a notable therapeutic difficulty. evaluating resistance rates of some a. baumannii isolates to tetracyclines had an impact on understanding the antibiotic resistance dissemination. by comparing genetic characteristics and relatedness of a. baumannii isolates, we are able to determine the transition dynamics of outbreak isolates. | 2017 | 28724383 |
| extensively and multi drug-resistant acinetobacter baumannii recovered from technosol at a dump site in croatia. | in a karst pit above city of rijeka in croatia the hazardous industrial waste was continuously disposed from 1955 to 1990, and later it was periodically used as an illegal dump site. the surface part of a technosol at the edge of dump was analysed mineralogically, geochemically and bacteriologically. from the technosol rich in petroleum hydrocarbons and heavy metals three isolates of acinetobacter baumannii were recovered. isolates from technosol shared many features that are previously describe ... | 2017 | 28724243 |
| combination of polymyxin b and meropenem eradicates persister cells from acinetobacter baumannii strains in exponential growth. | 2017 | 28721845 | |
| a human biofilm-disrupting monoclonal antibody potentiates antibiotic efficacy in rodent models of both staphylococcus aureus and acinetobacter baumannii infections. | many serious bacterial infections are antibiotic-refractory due to biofilm formation. a key structural component of biofilm is extracellular dna which is stabilized by bacterial proteins, including those from the dnabii family. trl1068 is a high affinity human monoclonal antibody against a dnabii epitope conserved across both gram-positive and gram-negative bacterial species. in the current study, the efficacy of trl1068 for disruption of biofilm was demonstrated in vitro in the absence of antib ... | 2017 | 28717038 |
| novel fri1-like viruses infecting acinetobacter baumannii-vb_abap_as11 and vb_abap_as12-characterization, comparative genomic analysis, and host-recognition strategy. | acinetobacter baumannii is a gram-negative, non-fermenting aerobic bacterium which is often associated with hospital-acquired infections and known for its ability to develop resistance to antibiotics, form biofilms, and survive for long periods in hospital environments. in this study, we present two novel viruses, vb_abap_as11 and vb_abap_as12, specifically infecting and lysing distinct multidrug-resistant clinical a. baumannii strains with k19 and k27 capsular polysaccharide structures, respect ... | 2017 | 28714913 |
| prioritizing multiple therapeutic targets in parallel using automated dna-encoded library screening. | the identification and prioritization of chemically tractable therapeutic targets is a significant challenge in the discovery of new medicines. we have developed a novel method that rapidly screens multiple proteins in parallel using dna-encoded library technology (elt). initial efforts were focused on the efficient discovery of antibacterial leads against 119 targets from acinetobacter baumannii and staphylococcus aureus. the success of this effort led to the hypothesis that the relative number ... | 2017 | 28714473 |
| a1s_2811, a chea/y-like hybrid two-component regulator from acinetobacter baumannii atcc17978, is involved in surface motility and biofilm formation in this bacterium. | two-component systems in acinetobacter baumannii are associated with its virulence, drug resistance, motility, biofilm formation, and other characteristics. in this study, we used recab , a genetic engineering method, to investigate the function of a1s_2811 in a. baumannii strain atcc17978. a1s_2811, a hypothetical hybrid sensor histidine kinase/response regulator, has four histidine-containing phosphotransfer domains, a chea-like regulatory domain, and a chey-like receiver domain at its c termi ... | 2017 | 28714256 |
| emergence of carbapenem-resistant acinetobacter baumannii st787 in clinical isolates from blood in a tertiary teaching hospital in northern taiwan. | the purpose of this study is to investigate the predominant clones of carbapenem-resistant acinetobacter baumannii (crab) in our hospital in taiwan by pulsed-field gel electrophoresis (pfge) and multilocus sequence typing (mlst) technique. | 2017 | 28711441 |
| bad bacteria in acute appendicitis: rare but relevant. | bacterial infections are a factor for morbidity in patients with acute appendicitis (aa). the spreading of multidrug-resistant (mdr) bacteria is a significant problem in surgery, and the most relevant mdr pathogens are summarized as enterobacteriaceae, staphylococcus aureus, klebsiella pneumoniae, acinetobacter baumannii, pseudomonas aeruginosa, and enterococci (eskape) bacteria. data regarding the species and distribution of bacteria in aa are available, but information about the resistances an ... | 2017 | 28710611 |
| the clinical and microbiological characteristics of infections in burn patients from the formosa fun coast dust explosion. | bloodstream infection is a leading cause of mortality among burn patients. this study aimed to evaluate the risk factors, causative pathogens, and the relationship between bloodstream infections and other infections among burn patients from the formosa fun coast dust explosion. | 2017 | 28705768 |
| isolation and whole-genome sequence analysis of the imipenem heteroresistant acinetobacter baumannii clinical isolate hrab-85. | heteroresistance is a phenomenon in which there are various responses to antibiotics from bacterial cells within the same population. here, we isolated and characterised an imipenem heteroresistant acinetobacter baumannii strain (hrab-85). | 2017 | 28705755 |
| effect of secondary metabolite of actinidia deliciosa on the biofilm and extra-cellular matrix components of acinetobacter baumannii. | acinetobacter baumannii, opportunistic nosocomial pathogen, increases gradually in the clinical setup. the high level of resistance mechanisms acquired by these bacteria makes their eradication difficult and biofilm formation is one of them. biofilm comprises of closely packed bacterial population crowded together by extra-cellular matrix (ecm). ecm contains bacterial secreted polymers such as exopolysaccharides (eps), proteins and extracellular-dna (e-dna) and rarely amyloidogenic proteins. bio ... | 2017 | 28705748 |
| pharmacodynamics of minocycline against acinetobacter baumannii studied in a pharmacokinetic model of infection. | minocycline (min) is an old antibiotic which may have an important role in the treatment of multidrug gram-negative infection as the burden of such infectious increase. | 2017 | 28705678 |
| in-vitro activity of the novel fluorocycline eravacycline against carbapenem non-susceptible acinetobacter baumannii. | the activity of eravacycline was compared with anti-acinetobacter reference antimicrobials against carbapenem non-susceptible acinetobacter baumannii isolates associated with an acquired oxa or up-regulation of the intrinsic oxa-51-like enzyme. antimicrobial susceptibility testing was performed by broth microdilution of 286 non-duplicate, carbapenem non-susceptible a. baumannii isolates to eravacycline, amikacin colistin, doxycycline, imipenem, levofloxacin, meropenem, minocycline, sulbactam, ti ... | 2017 | 28705668 |
| development of silver nanoparticles loaded chitosan-alginate constructs with biomedical potentialities. | herein, a facile biosynthesis of silver nanoparticles (agnps) and agnps-loaded chitosan-alginate constructs with biomedical potentialities is reported. the uv-vis spectroscopic profile confirmed the synthesis of agnps using methanolic leaves extract of euphorbia helioscopia. the newly developed agnps were characterized using various analytical and imaging techniques including uv-vis and ft-ir spectroscopy, x-ray diffraction (xrd), scanning electron microscopy (sem), energy dispersive spectroscop ... | 2017 | 28705499 |
| genotypic diversity among multidrug resistant pseudomonas aeruginosa and acinetobacter species at mulago hospital in kampala, uganda. | multidrug resistant pseudomonas aeruginosa and acinetobacter species are common causes of nosocomial infections worldwide. recently we reported the occurrence of carbapenem resistant enterobacteriaceae, p. aeruginosa and acinetobacter species at mulago national referral hospital in kampala, uganda, but the isolates were not analyzed for genetic relatedness. herein we report the intra-species genotypic diversity among p. aeruginosa and acinetobacter baumannii isolated from hospitalized patients a ... | 2017 | 28705201 |
| carbapenemase detection among carbapenem-resistant glucose-nonfermenting gram-negative bacilli. | accurate detection of carbapenemase-producing glucose-nonfermenting gram-negative bacilli (cpnfs), including pseudomonas aeruginosa and acinetobacter baumannii, is necessary to prevent their dissemination within health care settings. we performed a method comparison study of 11 phenotypic carbapenemase detection assays to evaluate their accuracy for the detection of cpnfs. a total of 96 carbapenem-resistant glucose-nonfermenting isolates were included, of which 29% produced carbapenemases. all c ... | 2017 | 28701421 |
| community-acquired bloodstream infections caused by acinetobacter baumannii: a matched case-control study. | acinetobacter baumannii is an important nosocomial pathogen worldwide. its role in community-acquired infection remains controversial and has rarely been reported. | 2017 | 28701266 |
| antimicrobial susceptibility among gram-positive and gram-negative organisms collected from the latin american region between 2004 and 2015 as part of the tigecycline evaluation and surveillance trial. | the in vitro activity of tigecycline and comparator agents was evaluated against gram-positive and gram-negative isolates collected in latin american centers between 2004 and 2015 as part of the tigecycline evaluation and surveillance trial (t.e.s.t.) global surveillance study. | 2017 | 28701170 |
| magnetic extraction of acinetobacter baumannii using colistin-functionalized γ-fe2o3/au core/shell composite nanoclusters. | acinetobacter baumannii is a gram-negative bacterium of increasing concern due to its virulence and persistence in combat and healthcare environments. the incidence of both community-acquired and nosocomial a. baumannii infections is on the rise in foreign and domestic healthcare facilities. treatment options are limited due to the acquisition of multidrug resistance to the few effective antibiotics. currently, the most effective pharmaceutically based treatment for multidrug-resistant a. bauman ... | 2017 | 28696672 |
| impact of broad-spectrum antimicrobial treatment on the ecology of intestinal flora. | suppression of intestinal flora by broad-spectrum antimicrobial agents facilitated risk of colonization or infection with resistant pathogen. we aimed to investigate the changes in bowel carriage of target resistant microorganisms (tro) among patients treated with three different classes of pseudomonas-sparing broad-spectrum antimicrobial agents (ertapenem, moxifloxacin and flomoxef) with anaerobic coverage. risk factors for developing colonization of tro were also analyzed. | 2017 | 28693929 |
| comparison of in-house and commercial real time-pcr based carbapenemase gene detection methods in enterobacteriaceae and non-fermenting gram-negative bacterial isolates. | carbapenemase-producing gram-negative bacteria are increasing globally and have been associated with outbreaks in hospital settings. thus, the accurate detection of these bacteria in infections is mandatory for administering the adequate therapy and infection control measures. this study aimed to establish and evaluate a multiplex real-time pcr assay for the simultaneous detection of carbapenemase gene variants in gram-negative rods and to compare the performance with a commercial rt-pcr assay ( ... | 2017 | 28693493 |
| incidence of oxa-23 and oxa-58 carbapenemases coexpressed in clinical isolates of acinetobacter baumannii in tunisia. | acinetobacter baumannii is an important opportunistic and multidrug-resistant pathogen responsible for nosocomial infections in health facilities. the aim of this study was to characterize the molecular mechanisms of carbapenem resistance in a. baumannii isolates isolated from mohamed kassab orthopedic institute in tunis, tunisia. twenty-five imipenem-resistant a. baumannii clinical isolates collected between 2013 and 2016 were identified using api 20ne and were confirmed by matrix-assisted lase ... | 2017 | 28691891 |
| investigation and analysis of the characteristics and drug sensitivity of bacteria in skin ulcer infections. | skin ulcer is a common type of disease affecting patients' health and quality of life, and bacterial infection increases the difficulty of its management. | 2017 | 28689800 |
| prolonged and high dosage of tigecycline - successful treatment of spondylodiscitis caused by multidrug-resistant acinetobacter baumannii: a case report. | the incidence of infectious spondylodiscitis has been increasing over the last few years. this reflects the expanding elderly and immunocompromised populations and the rising implementation of invasive spinal procedures. infection may be inoculated into the disc space directly during invasive spinal procedures. osteomyelitis caused by acinetobacter species is rare and mainly caused by multidrug-resistant strains. | 2017 | 28687078 |
| should we treat patients with only one set of positive blood cultures for extensively drug-resistant acinetobacter baumannii the same as multiple sets? | acinetobacter species are not considered skin commensals and under-treatment is an overriding concern when caring for critically-ill patients who are mostly at risk of extensively drug-resistant acinetobacter baumannii (xdrab) infections. hence even a single blood culture yielding xdrab will tend to prompt intervention. however, field observations suggest that patients with single-positive blood cultures had milder disease and were more likely to be recruited in interventional studies than those ... | 2017 | 28686744 |
| phytochemical studies on two australian anigozanthos plant species. | phytochemical studies of two australian anigozanthos (kangaroo paw) species, a. rufus and a. pulcherrimus, resulted in the identification of 13 secondary metabolites. 2-amino-6-o-p-coumarylheptanedioic acid (3) and chalcone-5'-o-(4-o-p-coumaryl)-o-β-d-glucopyranoside (12) are reported as new compounds and are accompanied by nine flavonoids (2, 5-11, 13) and two anthocyanins (1, 4). compounds 1 and 4 were isolated as red solids from a. rufus and are likely responsible for the coloration of the fl ... | 2017 | 28682615 |
| the respiratory threat posed by multidrug resistant gram-negative bacteria. | respiratory infections are a major cause of global mortality and morbidity. in recent years, an increased incidence of multidrug-resistant (mdr) gram-negative bacteria (gnb) has been described. microorganisms such as pseudomonas aeruginosa, escherichia coli, klebsiella pneumoniae or acinetobacter baumannii have been identified as causative pathogens of different respiratory tract infections. several studies have detected mdr-gnb in patients with community-acquired and nosocomial pneumonia. furth ... | 2017 | 28681941 |
| assessment of surgical risk factors in the development of ventilator-associated pneumonia in neurosurgical intensive care unit patients: alarming observations. | ventilator-associated pneumonia (vap) is the most frequent nosocomial infection in patients receiving mechanical ventilation (mv) and contributes to a longer intensive care unit (icu) stay, duration of mv, and a high morbidity and mortality. | 2017 | 28681751 |
| therapeutic drug monitoring for colistin therapy in severe multi-resistant acinetobacter intracerebral abscess: a single case study with high-dose colistin and review of literature. | intracranial infections due to multidrug- resistant (mdr) gram-negative pathogens are associated with increased morbidity and mortality. as therapeutic options are limited and systemic drug penetration into the infection focus is difficult, intraventricular therapy has been described. | 2017 | 28680633 |
| human neutrophils phagocytose and kill acinetobacter baumannii and a. pittii. | acinetobacter baumannii is a common cause of health care associated infections worldwide. a. pittii is an opportunistic pathogen also frequently isolated from acinetobacter infections other than those from a. baumannii. knowledge of acinetobacter virulence factors and their role in pathogenesis is scarce. also, there are no detailed published reports on the interactions between a. pittii and human phagocytic cells. using confocal laser and scanning electron microscopy, immunofluorescence, and li ... | 2017 | 28676640 |
| clinical and in vitro efficacy of colistin plus vancomycin and rifampin against colistin-resistant acinetobacter baumannii causing ventilator-associated pneumonia. | we present the case of a patient with ventilator-associated pneumonia (vap) caused by a pan-resistant acinetobacter baumannii successfully treated with the combination colistin plus vancomycin plus rifampin, whose in vitro activity was investigated by checkerboard method and killing testing. furthermore, the serum bactericidal activity (sba) was assessed. our case shows that an innovative regimen consisting of colistin plus antimicrobials active only against gram-positive microorganisms might re ... | 2017 | 28675246 |
| titanium surfaces immobilized with the major antimicrobial fragment fk-16 of human cathelicidin ll-37 are potent against multiple antibiotic-resistant bacteria. | infections on implanted medical devices are a challenging problem, especially when bacteria form difficult-to-treat biofilms. antimicrobial peptides are considered to be a solution due to their potency against antibiotic-resistant superbugs. previously, the authors' laboratory demonstrated the prevention of staphylococcal biofilm formation in an animal catheter model by injecting merecidin (formerly known as 17biphe2), a peptide engineered based on the only human cathelicidin. this study documen ... | 2017 | 28675109 |
| current problematic and emergence of carbapenemase-producing bacteria: a brief report from a libyan hospital. | a collection of 94 gram-negative bacteria isolates, showing different antimicrobial resistance phenotypes including to the carbapenem classes was investigated. strains were originated form clinical sources from a single hospital in tripoli, libya during 2015 and were identified based on cultural and phenotypic characteristics, and fully characterized by the vitek automated system. forty-eight percent (48%) of the collection was identified as acinetobacter baumannii, 50% klebsiella pneumoniae and ... | 2017 | 28674573 |
| subinhibitory concentrations of trimethoprim and sulfamethoxazole prevent biofilm formation by acinetobacter baumannii through inhibition of csu pilus expression. | acinetobacter baumannii is emerging as a multidrug-resistant nosocomial pathogen of increasing threat to human health worldwide. pili are important bacterial virulence factors, playing a role in attachment to host cells and biofilm formation. the csu pilus, which is assembled via the chaperone-usher secretion system, has been studied in a. baumannii atcc 19606. here we show that, in opposition to previous reports, the common laboratory strain atcc 17978 produces csu pili. we found that, although ... | 2017 | 28674047 |
| the distribution of carbapenem- and colistin-resistance in gram-negative bacteria from the tamil nadu region in india. | the occurrence of carbapenem- and colistin-resistance among gram-negative bacteria is increasing worldwide. the aim of this study was to understand the distribution of carbapenem- and colistin-resistance in two areas in tamil nadu, india. | 2017 | 28671537 |
| targeted surveillance and infection-related risk factors of nosocomial infection in patients after neurosurgical operation. | the purpose of this study was to investigate the risk factors of nosocomial infection in patients after neurosurgical operations, so as to provide reasonable, effective preventative measures in the future. a total of 1,600 patients with brain tumors, hydrocephalus, craniocerebral trauma and vascular disease treated in the neurosurgery room were chosen for targeted surveillance; and through analysis on the clinical data of patients, the incidence of nosocomial infection, the site of infection and ... | 2017 | 28671080 |
| extended-spectrum beta-lactamase producing gram negative bacteria in iran: a review. | the emergence and spread of extended spectrum β-lactamase (esbl)-producing gram- negative bacteria (gnb), particularly in enterobacteriaceae, acinetobacter baumannii, and pseudomonas aeruginosa, have increased all over the world. esbls are characterized by their ability to hydrolyze β-lactams, early cephalosporins, oxyimino-thiazolyl cephalosporins, and monobactams, but not cephamycins or carbapenems. the rate of nosocomial infections caused by esbl-producing gnb in asia pacific has increased an ... | 2017 | 28670639 |
| dna-triplex forming purine repeat containing genes in acinetobacter baumannii and their association with infection and adaptation. | 2017 | 28670571 | |
| inhaled colistin monotherapy for respiratory tract infections in adults without cystic fibrosis: a systematic review and meta-analysis. | inhaled colistin is becoming increasingly popular against respiratory tract infections due to multidrug resistant (mdr) gram-negative bacteria since it may overcome the problems associated with iv administration. | 2017 | 28669836 |
| meropenem selection induced overproduction of the intrinsic carbapenemase as well as phenotype divergence in acinetobacter baumannii. | acinetobacter baumannii 37662 is a carbapenem-susceptible isolate with blaoxa-51-like as the sole carbapenemase gene. following selection with meropenem (mem) at a subinhibitory concentration, two morphologically different mutants, designated 37662rm1 and 37662rm2, were obtained and characterised. compared with the parent strain, resistant mutant 37662rm1 grew at a slower rate and had impaired capsule synthesis, whereas 37662rm2 grew fast and abolished capsule synthesis. in addition, the latter ... | 2017 | 28669829 |
| sensitivity and specificity of matrix-associated laser desorption/ionization - time of flight mass spectrometry (maldi-tof ms) in discrimination at species level for acinetobacter bacteremia. | we aimed to establish the role of maldi-tof ms on species discrimination of phenotypically indistinguishable a. baumannii, a. pittii and a. nosocomialis. compared to multiplex pcr, the gold standard, maldi-tof ms yielded a high sensitivity for a. baumannii (97.9%) and specificity for a. pittii (98.9%) and a. nosocomialis (100%). | 2017 | 28669800 |
| origin of the abgri1 antibiotic resistance island found in the comm gene of acinetobacter baumannii gc2 isolates. | 2017 | 28666372 | |
| etx2514 is a broad-spectrum β-lactamase inhibitor for the treatment of drug-resistant gram-negative bacteria including acinetobacter baumannii. | multidrug-resistant (mdr) bacterial infections are a serious threat to public health. among the most alarming resistance trends is the rapid rise in the number and diversity of β-lactamases, enzymes that inactivate β-lactams, a class of antibiotics that has been a therapeutic mainstay for decades. although several new β-lactamase inhibitors have been approved or are in clinical trials, their spectra of activity do not address mdr pathogens such as acinetobacter baumannii. this report describes t ... | 2017 | 28665414 |
| does acinetobacter baumannii serve as a source for blandm dissemination into enterobacteriaceae in hospitalized patients? | the goal was to study the possibility that acinetobacter baumannii serve as an epidemiologically significant source for transmission of the blandm gene to enterobacteriaceae by horizontal gene transfer (hgt) in hospitalized patients. the study was done at the tel-aviv sourasky medical center from december 2014 until august 2015. clinical and surveillance rectal cultures were collected as per hospital policies and were analyzed for the presence of new delhi metallo-beta-lactamase-producing entero ... | 2017 | 28665176 |
| analysis of acinetobacter baumannii resistance patterns in patients with chronic obstructive pulmonary disease (copd) in terms of choice of effective empiric antibiotic therapy. | <b>introduction.</b> multi-resistant acinetobacter baumannii isolated from patients has become one of the most hazardous pathogens in health care settings. the aim of the study was to analyze pneumonia caused by acinetobacter baumannii in patients hospitalized because of exacerbation of chronic obstructive pulmonary diseases (copd), who were admitted to the pulmonology ward of the masovian specialistic hospital in radom (mss). the incidence and drug sensitivity of these non-fermenting rods were ... | 2017 | 28664714 |