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ecological factors influencing small mammal infection by anaplasma phagocytophilum and borrelia burgdorferi s.l. in agricultural and forest landscapes.small mammals are key components of numerous tick-borne disease systems, as hosts for immature ticks and pathogen reservoirs. to study the factors influencing tick-borne infection in small mammals, we trapped small mammals and collected questing ticks in spring and autumn in 2012 and 2013 at 24 sites in a 10x15 km rural landscapes (brittany, france). tissue samples were screened by real-time pcr for anaplasma phagocytophilum and borrelia burgdorferi sensu lato. of the two dominant small mammal s ...201728799685
risk factors for severe infection, hospitalization, and prolonged antimicrobial therapy in patients with babesiosis.babesiosis is an emerging tick-borne disease transmitted by the hard tick ixodes scapularis, which also transmits lyme disease. better gradation of prognostic indicators are needed to determine which patients may develop serious complications requiring hospitalization, and to provide early guidance on appropriate therapy. in this study, we evaluated 128 patients with smear or real time polymerase chain reaction-confirmed babesia microti infections over a period of 16 years. patients with aspleni ...201728722598
reciprocal cooperation of phytochemicals and micronutrients against typical and atypical forms of borrelia sp.borrelia sp., a causative pathogenic factor of lyme disease (ld), has become a major public health threat. current treatments based on antibiotics often lead to relapse after their withdrawal. naturally derived substances that could work synergistically to display higher efficacy compared with the individual components may serve as a resource for the development of novel approaches to combat both active and latent forms of borrelia sp.201728644529
brave new worlds: the expanding universe of lyme disease.projections around the globe suggest an increase in tick-vectored disease incidence and distribution, and the potential for emergence of novel tick-borne pathogens. lyme disease is the most common reported tick-borne illness in the unites states and is prevalent throughout much of central europe. in recent years, the worldwide burden of lyme disease has increased and extended into regions and countries where the disease was not previously reported. in this review, we discuss the trends for incre ...201728727515
serologic evidence of powassan virus infection in patients with suspected lyme disease(1).powassan virus (powv) lineage ii is an emerging tickborne flavivirus with an unknown seroprevalence in humans. in a lyme disease-endemic area, we examined the seroreactivity to powv in 2 patient cohorts and described the clinical features of the powv-seroreactive patients. powv disease might be less neuroinvasive than previously thought.201728726610
progression of lyme disease to bell's palsy despite treatment with doxycycline. 201728705754
crossed total hemiatrophy associated with atrophoderma of pasini-pierini.a 45-year-old chinese man had begun to show asymmetry of the face 30 years previously. subsequently, he developed visual extinction of the right eye, slight numbness, and weakness of the left extremities. simultaneously, multiple atrophic brownish patches occurred on his side. he denied prior trauma or tick bites at those sites. there was no report of preceding redness, induration, or a history of trauma. the atrophic lesions extended and enlarged slowly. ten years previously, some brownish patc ...201728705290
[one year of infectious diseases : a review].several outbreaks have made the news in 2016 : ebola has come at an end, zika is booming and a resurgence of yellow fever takes place in africa. in switzerland, two hospital outbreaks have been reported, caused by mycobacterium chimerae and burkholderia cepacia. a major new article has consolidated the notion that prolonged antibiotic therapy is unnecessary in lyme disease. as multiresistant bacteria are increasing in frequency, innovative therapeutic approaches are under development. for lung i ...201728703540
the role of host immune cells and borrelia burgdorferi antigens in the etiology of lyme disease.lyme disease is a zoonosis caused by infection with bacteria belonging to the borrelia burgdorferi species after the bite of an infected tick. even though an infection by this bacterium can be effectively treated with antibiotics, when the infection stays unnoticed b. burgdorferi can persist and chronic post-treatment lyme disease syndrome is able to develop. although a cellular and humoral response is observed after an infection with the borrelia bacteria, these pathogens are still capable to s ...201728840838
chronic lyme disease: an unresolved controversy. 201728838739
sleeper cells: the stringent response and persistence in the borreliella (borrelia) burgdorferi enzootic cycle.infections with tick-transmitted borreliella (borrelia) burgdorferi, the cause of lyme disease, represent an increasingly large public health problem in north america and europe. the ability of these spirochetes to maintain themselves for extended periods of time in their tick vectors and vertebrate reservoirs is crucial for continuance of the enzootic cycle as well as for the increasing exposure of humans to them. the stringent response mediated by the alarmone (p)ppgpp has been determined to b ...201728836724
babesiosis surveillance - wisconsin, 2001-2015.babesiosis is an emerging zoonotic disease caused primarily by babesia microti, an intraerythocytic protozoan. babesia microti, like the causal agents for lyme disease and anaplasmosis, is endemic to the northeastern and upper midwestern united states where it is usually transmitted by the blacklegged tick, ixodes scapularis. although babesiosis is usually a mild to moderate illness, older or immunocompromised persons can develop a serious malaria-like illness that can be fatal without prompt tr ...201728683059
nonpyrogenic molecular adjuvants based on norabu-muramyldipeptide and norabu-glucosaminyl muramyldipeptide: synthesis, molecular mechanisms of action, biological activities in vitro and in vivo.apyrogenic fatty acyl analogues of muramyldipeptide (mdp) (abbreviated n-l18norabugmdp, n-b30norabugmdp, norabumdp-lys(l18), norabumdp-lys(b30), norabugmdp-lys(l18), norabugmdp-lys(b30), (b30)norabumdp, (l18)norabumdp) were designed and synthesized comprising the normuramyl-l-α-aminobutanoyl (norabu) structural moiety. all new analogues show depressed pyrogenicity both as free compounds and in liposomal formulations when tested in vivo in rabbits (s.c. and i.v. application). the potency of analo ...201728829599
postinfectious anti-myelin oligodendrocyte glycoprotein antibody positive optic neuritis and myelitis.we report the case of a 9-year-old girl admitted with fever, headache, and a cerebrospinal fluid lymphocytic pleocytosis. polymerase chain reaction was positive for human herpes virus 6. she subsequently developed ataxia and bilateral loss of vision. magnetic resonance imaging (mri) showed bilateral optic nerve lesions with extension to optic chiasm and a short-segment myelitis. serologic studies were positive for borrelia burgdorferi igm. anti-aquaporin 4 antibody was negative and anti-myelin o ...201728820014
suicidal and homicidal tendencies after lyme disease: an ignored problem. 201728814875
lyme borreliosis in finland, 1995-2014.we investigated the epidemiology of lyme borreliosis (lb) in finland for the period 1995-2014 by using data from 3 different healthcare registers. we reviewed data on disseminated lb cases from the national infectious diseases register (21,051 cases) and the national hospital discharge register (10,402 cases) and data on primary lb (erythema migrans) cases from the register for primary health care visits (11,793 cases). incidence of microbiologically confirmed disseminated lb cases increased fro ...201728726624
diagnosis of lyme-associated uveitis: value of serological testing in a tertiary centre.to determine the frequency and clinical presentation of lyme disease in patients with uveitis and to assess the value of borrelia burgdorferi serological testing.201728659389
[research progress in laboratory diagnosis of lyme disease]. 201728780833
tick microbiome and pathogen acquisition altered by host blood meal.lyme disease, a zoonotic disease, is the most prevalent vector-borne disease in the northern hemisphere. diversity of the vector (tick) microbiome can impact pathogen transmission, yet the biotic and abiotic factors that drive microbiome diversity are largely unresolved, especially under natural, field conditions. we describe the microbiome of ixodes pacificus ticks, the vector for lyme disease in the western united states, and show a strong impact of host blood meal identity on tick microbiome ...201727858931
claims-based diagnostic patterns of patients evaluated for lyme disease and given extended antibiotic therapy.a lyme disease (ld) diagnosis can be far from straightforward, particularly if erythema migrans does not develop or is not noticed. extended courses of antibiotics for ld are not recommended, but their use is increasing. we sought to elucidate the patient patterns toward a diagnosis of ld, hypothesizing that a subset of patients ultimately receiving extended courses antibiotics may be symptomatic for an extended period before the first ld diagnosis.201727855040
exposure and preventive behaviours toward ticks and lyme disease in canada: results from a first national survey.lyme disease (ld) risk is increasing in canada. in 2014, the government of canada launched a national communication campaign to raise awareness and promote the adoption of individual preventive behaviours toward ticks and ld. the objectives of this study were to evaluate and compare the adoption of ld preventive behaviours and the exposure to tick bites of canadians in the five main targeted regions (british columbia, prairie provinces, ontario, quebec and the atlantic provinces). a national sur ...201727771334
hemifacial spasm from lyme disease: antibiotic treatment points to the cause.a wide range of etiologies can cause hemifacial spasm (hfs), including infection. in this case report, a 44-year-old woman developed hfs and was explored surgically 7 years later. no abnormalities were found. afterward, treatment of a surgical wound infection with an oral cephalosporin resulted in a temporary hfs remission that had never occurred previously. this antibiotic experience prompted further workup for an underlying infection, which ultimately led to diagnosis of lyme disease. presenta ...201727755133
the effect of climate change on skin disease in north america.global temperatures continue to rise, reaching new records almost every year this decade. although the causes are debated, climate change is a reality. consequences of climate change include melting of the arctic ice cap, rising of sea levels, changes in precipitation patterns, and increased severe weather events. this article updates dermatologists about the effects of climate change on the epidemiology and geographic ranges of selected skin diseases in north america. although globalization, tr ...201727742170
digital health: tracking physiomes and activity using wearable biosensors reveals useful health-related information.a new wave of portable biosensors allows frequent measurement of health-related physiology. we investigated the use of these devices to monitor human physiological changes during various activities and their role in managing health and diagnosing and analyzing disease. by recording over 250,000 daily measurements for up to 43 individuals, we found personalized circadian differences in physiological parameters, replicating previous physiological findings. interestingly, we found striking changes ...201728081144
the jarisch-herxheimer reaction after antibiotic treatment of spirochetal infections: a review of recent cases and our understanding of pathogenesis.within 24 hours after antibiotic treatment of the spirochetal infections syphilis, lyme disease, leptospirosis, and relapsing fever (rf), patients experience shaking chills, a rise in temperature, and intensification of skin rashes known as the jarisch-herxheimer reaction (jhr) with symptoms resolving a few hours later. case reports indicate that the jhr can also include uterine contractions in pregnancy, worsening liver and renal function, acute respiratory distress syndrome, myocardial injury, ...201728077740
environmental factors affecting survival of immature ixodes scapularis and implications for geographical distribution of lyme disease: the climate/behavior hypothesis.recent reports suggest that host-seeking nymphs in southern populations of ixodes scapularis remain below the leaf litter surface, while northern nymphs seek hosts on leaves and twigs above the litter surface. this behavioral difference potentially results in decreased tick contact with humans in the south, and fewer cases of lyme disease. we studied whether north-south differences in tick survival patterns might contribute to this phenomenon. four month old larvae resulting from a cross between ...201728076359
succinyl-β-cyclodextrin modified gold biochip improved seroimmunological detection sensitivity for lyme disease.cyclodextrin (cd) is a kind of cyclic oligosaccharides, which forms host-guest interactions with hydrophobic molecules and is widely applied in capillary electrophoresis and pharmaceutical engineering. in this study, we established a succinyl-β-cd modified gold biochip for improvement of seroimmunological detection sensitivity of lyme disease. we found that the cd modified biochip platform presented a stronger affinity property for vlse protein in conjugation with >0.000475 μg/ml of antigen immo ...201728010742
lyme arrhythmia in an avid golfer: a diagnostic challenge and a therapeutic dilemma.lyme disease is a multisystem disorder affecting dermatologic, cardiac, nervous and musculoskeletal systems. cardiac manifestations occur in about 5% of lyme infections and stem from the involvement of the cardiac conduction system, resulting in varying degrees of sino-atrioventricular block. occasionally, lyme infection may also present with myopericarditis. unlike isolated conduction node disease, myocardial involvement presents a great diagnostic and therapeutic dilemma for the physician. we ...201727909484
colonic spirochetosis in a 60-year-old immunocompetent patient: case report and review.spirochetes, a genetically and morphologically distinct group of bacteria, are thin, spiral-shaped, and highly motile. they are known causes of several human diseases such as syphilis, lyme disease, relapsing fever, and leptospirosis. we report a case of colonic spirochetosis in a healthy patient presenting for surveillance colonoscopy. the diagnosis of intestinal spirochetosis was made accidentally during the histological examination of colonic polyps, which were removed during colonoscopy. we ...201727570780
[acute transverse myelitis in a traveler].acute transverse myelitis is defined as an acquired neuroimmune disorder of the spinal cord, which occurs as a consequence of a primary event, or directly related to an autoimmune inflammatory disease, an infectious or post-infectious disease. amongst infectious etiologies, borrelia spp., a tick-bourne anthropozoonosis of the ixodidae family, prevails. approximately 10 to 15% of patients with lyme disease undergo neurologic manifestations, with an assorted and uncertain array of clinical syndrom ...201727576284
diagnostic lumbar puncture among children with facial palsy in a lyme disease endemic area.we identified 620 children with peripheral facial palsy of which 211 (34%) had lyme disease. the 140 children who had a lumbar puncture performed were more likely to be hospitalized (73% lp performed vs 2% no lp) and to receive parenteral antibiotics (62% lp performed vs 6% no lp).201727422867
a presentation of lyme disease: pseudotumor cerebri.lyme disease is caused by a tick-transmitted spirochete, b. burgdorferi. it can present with both central and peripheral nervous system manifestations, including aseptic meningitis, meningoencephalitis, bell's palsy and other cranial neuropathies, radiculoneuritis, and myelitis. however, pseudotumor cerebri associated with lyme disease is rare. here, we report a eight-year-old girl with the unusual manifestation of pseudotumor cerebri associated lyme disease.201727411423
bilateral vestibular hypofunction and lyme disease: a causal link? 201727271288
yamamoto new scalp acupuncture, applied kinesiology, and breathing exercises for facial paralysis in a young boy caused by lyme disease-a case report.the case study reports on the effect of pharmacological, complementary, and alternative medicine including ynsa, applied kinesiology, and respiratory exercises in a 9-year-old boy with facial paralysis. the boy suffered from borreliosis and one-sided facial paralysis that occurred 3.5 weeks after being bitten by a tick and persisted despite 4 weeks of medication with antibiotics. in the first treatment, muscle function as assessed by the coachman׳s test was normalized, and improvement in the fac ...201727102135
the joint synovium: a critical determinant of articular cartilage fate in inflammatory joint diseases.the synovium constitutes the envelope of articular joints and is a critical provider of synovial fluid components and articular cartilage nutrients. its inflammation is a predominant feature and cause of joint degeneration in diseases as diverse as rheumatoid, psoriatic, juvenile and idiopathic arthritis, and lupus, gout and lyme disease. these inflammatory joint diseases (ijds) are due to a wide variety of genetic, epigenetic and environmental factors that trigger, promote, and perpetuate joint ...201727212252
laboratory evaluation of vocal fold paralysis and paresis.this study aimed to assess the value of comprehensive laboratory evaluation in patients with vocal fold paralysis or paresis.201727777055
ceftriaxone-induced immune hemolytic anemia as a life-threatening complication of antibiotic treatment of 'chronic lyme disease'.'chronic lyme disease' is a controversial condition. as any hard evidence is lacking that unresolved systemic symptoms, following an appropriately diagnosed and treated lyme disease, are related to a chronic infection with the tick-borne spirochaetes of the borrelia genus, the term 'chronic lyme disease' should be avoided and replaced by the term 'post-treatment lyme disease syndrome.' the improper prescription of prolonged antibiotic treatments for these patients can have an impact on the commu ...201727169474
[occurrence of occupational diseases in poland, 2014].the aim of the annual analysis of the incidence of occupational diseases in poland is to evaluate the extent of the incidence and to identify its causes as well as activities involving factors that are harmful or annoying to such an extent that they result in occupational diseases.201727364107
susceptibility, likelihood to be diagnosed, worry and fear for contracting lyme disease.risk perception and psychological concerns are relevant for understanding how people view lyme disease. this study investigates the four separate outcomes of susceptibility, likelihood to be diagnosed, worry, and fear for contracting lyme disease. university students (n=713) were surveyed about demographics, perceived health, lyme disease knowledge, lyme disease preventive behaviors, lyme disease history, and lyme disease miscellaneous variables. we found that women were associated with increase ...201727026135
articular manifestations in patients with lyme disease.to determine the percentage of lyme patients with articular manifestations in nw spain and to know their evolution and response to treatment.201726706656
living in limbo: contested narratives of patients with chronic symptoms following lyme disease.persistent, subjective symptoms of unknown etiology following treatment for lyme disease have been termed post- treatment lyme disease syndrome or chronic lyme disease (ptlds/cld). the objective of this study was to give primacy to the patient experience of this medically contested condition by eliciting patient illness narratives and identifying emergent issues through semistructured interviews conducted among 29 participants. we used thematic narrative analysis to identify three predominant th ...201726631681
association of lyme disease and schizoaffective disorder, bipolar type: is it inflammation mediated?lyme disease has been reported to be associated with various psychiatric presentations. borreliaburgdorferi (bb) can present with symptoms similar to schizophrenia and bipolar disorder. it has been suggested that inflammation incurred during the bb infection leads to neurodegenerative changes that result in schizophrenia-like presentations. we report a case of a 41-year-old male with a past history of bb infection who presents with psychosis. later in the course of his hospitalization, he develo ...201725969618
[epidemiology of lyme disease in a healthcare area in north-west spain].to evaluate the influence of some risk factors on the incidence rate of lyme disease and the main clinical manifestations.201725726250
correlates of perceived health-related quality of life in post-treatment lyme encephalopathy.marked functional impairment has been reported by patients with post-treatment lyme disease syndrome (ptlds).201723845316
wegener's granulomatosis with cardiac involvement masquerading as lyme disease.cardiac conduction disease is an infrequent complication of wegener's granulomatosis (wg). we describe a case demonstrating an association between wg and complete atrioventricular dissociation. this manifestation was initially interpreted as lyme disease based on these cardiac findings, arthritis, myalgias and positive lyme serology. the clinical overlap between these disorders and the appropriate use of respective serologies is discussed.201714611118
overdiagnosis and overtreatment of lyme disease leads to inappropriate health service use. 201710084029
lyme disease: a world-wide borreliosis. 20173067922
isolation and cultivation of lyme disease spirochetes.the successful isolation and cultivation of lyme disease spirochetes traces its lineage to early attempts at cultivating relapsing fever borreliae. observations on the growth of lyme disease spirochetes under different in vitro conditions may yield important clues to both the metabolic characteristics of these newly discovered organisms and the pathogenesis of lyme disease.20176393604
european erythema migrans disease and related disorders.european erythema migrans disease, lymphocytoma, and acrodermatitis chronica are a group of disorders associated with the bite of ixodid ticks. these disorders are now thought to be due to a single, or closely related, ixodid tick spirochetes. european erythema migrans disease closely resembles lyme disease. serological evaluation may help to separate spirochetal lymphocytoma from other pseudolymphomas of nonspirochetal origin and from lymphoma. acrodermatitis chronica atrophicans, so far observ ...20176549090
saturable, high-avidity monocyte receptors for monomeric igg and fc fragments increase in sle and lyme disease.we have devised an assay for quantifying high-avidity fc receptors for monomeric igg on peripheral blood monocytes. in the development of a radiolabelled ligand for the assay, we found that fc fragments offer several advantages over 7s-igg. compared to the latter ligand, the fragments interacted more cleanly with a single high-avidity binding site, appeared to have easier access to this site, and, since they showed no binding to millipore filters, their use made possible a wash procedure that wa ...20176241857
neurological findings of lyme disease.neurologic involvement of lyme disease typically consists of meningitis, cranial neuropathy, and radiculoneuritis, alone or in combination, lasting for months. from 1976 to 1983, we studied 38 patients with lyme meningitis. headache and mild neck stiffness, which fluctuated in intensity, and lymphocytic pleocytosis were the common findings. half of the patients also had facial palsies, which were unilateral in 12 and bilateral in seven. in addition, 12 patients had motor and/or sensory radiculon ...20166516450
[2 severe neurologic forms of lyme disease]. 20162949299
the clinical spectrum and treatment of lyme disease.lyme disease was recognized as a separate entity because of close geographic clustering of affected children in lyme, connecticut, with what was thought to be juvenile rheumatoid arthritis. it then became apparent that lyme disease is a complex, multisystem disorder. the illness usually begins in summer with erythema chronicum migrans and associated symptoms (stage 1). weeks to months later, some patients develop neurologic or cardiac abnormalities (stage 2), and weeks to years later, many patie ...20166516448
cellular immune findings in lyme disease.from 1981 through 1983, we did the first testing of cellular immunity in lyme disease. active established lyme disease was often associated with lymphopenia, less spontaneous suppressor cell activity than normal, and a heightened response of lymphocytes to phytohemagglutinin and lyme spirochetal antigens. thus, a major feature of the immune response during active disease seems to be a lessening of suppression, but it is not yet known whether this response plays a role in the pathophysiology of t ...20166240164
recovery of lyme disease spirochetes from patients.since the summer of 1982, we have cultured patient specimens for lyme disease spirochetes. of 118 patients cultured, four specimens yielded spirochetes: two from blood, one from a skin biopsy specimen of erythema chronicum migrans (ecm), and one from cerebrospinal fluid. all four isolates appeared identical when examined with a monoclonal antibody. however, attempts to recover the spirochete from synovium or synovial fluid were unsuccessful. in addition, the organism could not be visualized in s ...20166393606
quality of lyme disease tests. 20162685385
from the centers for disease control. lyme disease surveillance--united states, 1989-1990. 20162061968
[peripheral neuropathy and rhizomelic pseudo-polyarthritis: lyme disease]. 20161661913
diagnosis, treatment, and prevention of lyme disease. 20169757845
diagnosis, treatment, and prevention of lyme disease. 20169757844
diagnosis, treatment, and prevention of lyme disease. 20169757843
diagnosis, treatment, and prevention of lyme disease. 20169757842
lyme disease and secondary depression: universal lessons from an uncommon case. 20169664783
optic neuritis in children.to describe the clinical characteristics of optic neuritis in children, including final visual acuity and development of multiple sclerosis (ms).201611020105
from the centers for disease control and prevention. lyme disease--united states, 1995. 20168656527
cluster of lyme disease cases at a summer camp in kent county, maryland. 20168903195
[transmissible and natural infections in siberia and the far east].the common and specific features in the time course and structure of morbidity as regards tick-borne rickettsiasis, tick-borne encephalitis, and lyme disease in siberia and far east are discussed. the differentiation of nosological areas of tick-borne rickettsiasis and encephalitis is demonstrated and 9 variants of ratios of epidemiological zones of different hazard of infection established. the subject of comparative epidemiology of focal infections is formulated. general conceptual approaches ...20169273148
antibiotic therapy for lyme disease in maryland.the recommended treatment of lyme disease is evolving and important questions remain unanswered, such as (a) are inexpensive oral regimens effective in curing acute illness and preventing arthritic, neurologic, and cardiac manifestations or are much more costly, and potentially toxic, intravenous antibiotics required? (b) are relatively short 2- to 3-week courses of antibiotics sufficient or are prolonged regimens of a month, or more, better? this study reviews antibiotic therapy prescribed by m ...20167800782
hepatitis associated with lyme disease. 20161462798
national survey of state epidemiologists to determine the status of lyme disease surveillance.in 1990, the council of state and territorial epidemiologists and the centers for disease control made lyme disease (ld) nationally notifiable and developed a national case definition. state epidemiologists were surveyed about their state ld surveillance system. responses were received from all states and the district of columbia. as of november 1991, ld was notifiable in 45 states. a total of 44 of these 45 states use the 1990 national case definition for case confirmation. twenty-five state he ...20161333618
preventive behaviors and knowledge of tick-borne illnesses: results of a survey from an endemic area.lyme disease (ld) is the most commonly reported vector-borne illness in the united states. with physically and economically burdensome effects, it is a concern of public health officials.201624762630
occluso-facial manifestations in a child with the rasmussen syndrome and intercurrent lyme disease--a case report.the rasmussen syndrome (rs) is a rare neurological disease, usually diagnosed in the 1st decade of life, leading to damage of the central nervous system. it is characterised by sudden seizures in previously healthy children. in this paper we present a case of a 14-year-old female patient with malocclusion who reported to the orthodontic clinic to start orthodontic treatment. the first symptoms of nervous system disorders manifested when the patient was 8 years old. until then, the patient had be ...201626982755
an unrecognized rash progressing to lyme carditis: important features and recommendations regarding lyme disease.we present a case report of 46-year-old man with no medical history, who complained of extreme fatigue, near-syncope, and palpitations. he initially presented in complete heart block. a transvenous pacemaker was placed in the emergency department, and he was started empirically on ceftriaxone for lyme disease. he was admitted and over the course of the next few days, his rhythm regressed to mobitz type i first-degree atrioventricular block and then to normal sinus rhythm. this case report highli ...201625730155
[lyme disease in paediatrics]. 201626254967
managing monoarthritis in children.monoarthritis, defined as inflammation of a single joint, requires a thorough physical examination in children, as pain may be lacking in 10% to 30% of cases and joint stiffness may be the only symptom. joint aspiration is a crucial diagnostic tool that remains markedly underused. joint aspiration may be unnecessary, however, when the family history or other investigations provide the diagnosis. radiographs of the involved joint may supply information on the severity of the lesions. in doubtful ...201626253943
tick repellents and acaricides of botanical origin: a green roadmap to control tick-borne diseases?arthropods are dangerous vectors of agents of deadly diseases, which may hit as epidemics or pandemics in the increasing world population of humans and animals. among them, ticks transmit more pathogen species than any other group of blood-feeding arthropods worldwide. thus, the effective and eco-friendly control of tick vectors in a constantly changing environment is a crucial challenge. a number of novel routes have been attempted to prevent and control tick-borne diseases, including the devel ...201627146901
[lyme disease: where is the controversy?]. 201626206702
critical review of studies trying to evaluate the treatment of chronic lyme disease. 201626206701
lyme disease.occupational and environmental health nurses should educate workers about ways to prevent tick bites, which can cause lyme disease.201626585171
testing practices and volume of non-lyme tickborne diseases in the united states.large commercial laboratories in the united states were surveyed regarding the number of specimens tested for eight tickborne diseases in 2008. seven large commercial laboratories reported testing a total of 2,927,881 specimens nationally (including lyme disease). of these, 495,585 specimens (17%) were tested for tickborne diseases other than lyme disease. in addition to large commercial laboratories, another 1051 smaller commercial, hospital, and government laboratories in four states (ct, md, ...201626565931
causes of neuropathy in patients referred as "idiopathic neuropathy".the etiology of neuropathy was idiopathic in 20%-30% of patients despite thorough investigation, based on results from the 1980s and 1990s. since then, new etiologies have been recognized, and skin biopsy has been used to confirm small-fiber neuropathy.201626561790
babesiosis and lyme disease co-infection in a female patient returning from the united states. 201626525187
severe symptomatic babesiosis co-infection with lyme disease. 201626370123
lyme myocarditis presenting as chest pain in an adolescent girl.a previously healthy adolescent girl presented to the emergency department with new onset chest and right upper quadrant abdominal pain. laboratory studies and imaging were consistent with myocarditis. she developed heart block after admission and required stabilization in the cardiac intensive care unit. lyme serology returned positive, and her condition was diagnosed as lyme disease-associated myocarditis.201626945194
serum carnitine concentration is decreased in patients with lyme borreliosis.lyme borreliosis (lb) is a serious infectious disease. carnitine plays a crucial role in metabolism and inflammatory responses. carnitine may be important in improving neuronal dysfunction and loss of neurons.201626943315
[the combination of laryngeal paresis in the patients presenting with systemic tick-borne borreliosis (lyme disease)]. 201626977572
[incidence of lyme disease in spain]. 201626971976
unusual presentation of unilateral isolated probable lyme optic neuritis.optic neuritis (on) is one of the most common manifestations of central nervous system involvement caused by various etiologies. lyme on is an exceedingly rare ocular manifestation of lyme disease (ld) and only a few cases have been published in the literature. lyme on is very rare but should be included in the differential diagnosis in unexplained cases, particularly in lyme endemic areas. careful and detailed examination and investigation are warranted to make the diagnosis. we report this cas ...201626953086
response to letter regarding article "how far north are migrant birds transporting the tick ixodes scapularis in canada? insights from stable hydrogen isotope analyses of feathers".in this letter we respond to correspondence and clarify the intent and importance of our article.201626776880
approach to diagnosing lyme disease misses a large proportion of cases. 201626762319
tick-borne disease prevention: still no silver bullet. 201626740277
effectiveness of residential acaricides to prevent lyme and other tick-borne diseases in humans.in the northeastern united states, tick-borne diseases are a major public health concern. in controlled studies, a single springtime application of acaricide has been shown to kill 68%-100% of ticks. although public health authorities recommend use of acaricides to control tick populations in yards, the effectiveness of these pesticides to prevent tick bites or human tick-borne diseases is unknown.201626740276
lyme disease surveillance using sampling estimation: evaluation of an alternative methodology in new york state.in the 14-year period from 1993 to 2006, new york state (nys) accounted for over one-quarter (27.1%) of all confirmed lyme disease (ld) cases in the united states. during that time period, a nine-county area in south-east nys accounted for 90.6% of the reported ld cases in the state. based on concerns related to diminishing resources at both the state and local level and the increasing burden of traditional ld surveillance, the nys department of health (doh) sought to develop an alternative to t ...201626924579
increase in ticks and lyme borreliosis, yet research into its prevention on the wane.there is increased concern about the upward incidence of lyme borreliosis (lb) in europe, the united states, asia, and northern africa. however, effective measures to control tick populations or vaccines for lb are not yet available. therefore, behavioral measures including avoidance of areas inhabited by ticks, performing routine body checks, using protective clothing, and the application of tick repellents are of great importance. unfortunately, acceptance and uptake of many of these preventiv ...201626901844
probable doxycycline-induced acute pancreatitis.a probable case of doxycycline-induced pancreatitis is reported.201626896500
past and future perspectives on mathematical models of tick-borne pathogens.ticks are vectors of pathogens which are important both with respect to human health and economically. they have a complex life cycle requiring several blood meals throughout their life. these blood meals take place on different individual hosts and potentially on different host species. their life cycle is also dependent on environmental conditions such as the temperature and habitat type. mathematical models have been used for the more than 30 years to help us understand how tick dynamics are ...201626683345
tick-borne disease preventive practices and perceptions in an endemic area.lyme disease is the most commonly reported vector-borne illness in the united states. since the institution of nationally notifiable surveillance efforts for lyme disease in the united states in 1991, there has been a consistent increase in the number of reported cases. thus, the need for targeted prevention strategies is underscored. the purpose of this study was to investigate knowledge about tick-borne diseases as well as beliefs and practices related to a variety of personal tick-borne disea ...201626704290
sequential insults: acute lyme disease with splenic infarction. 201626688425
impact of spring bird migration on the range expansion of ixodes scapularis tick population.many observational studies suggest that seasonal migratory birds play an important role in spreading ixodes scapularis, a vector of lyme disease, along their migratory flyways, and they are believed to be responsible for geographic range expansion of i. scapularis in canada. however, the interplay between the dynamics of i. scapularis on land and migratory birds in the air is not well understood. in this study, we develop a periodic delay meta-population model which takes into consideration the ...201626688012
will culling white-tailed deer prevent lyme disease?white-tailed deer play an important role in the ecology of lyme disease. in the united states, where the incidence and geographic range of lyme disease continue to increase, reduction of white-tailed deer populations has been proposed as a means of preventing human illness. the effectiveness of this politically sensitive prevention method is poorly understood. we summarize and evaluate available evidence regarding the effect of deer reduction on vector tick abundance and human disease incidence. ...201626684932
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