Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| molecular epidemiology and divergence of hiv type 1 protease codon 35 inserted strains among treatment-naive patients in hong kong. | this study reported the prevalence and pattern of viral replication-associated hiv-1 protease codon 35 amino acid insertions among treatment-naive patients in hong kong. the transmission and divergence date of these inserted strains was also investigated. the pol gene of 264 local hiv-1 isolates was sequenced and phylogenetic analysis was performed. the transmission history of protease codon 35-inserted hiv-1 strains in hong kong was estimated by the bayesian coalescent method. this insertion wa ... | 2008 | 18426335 |
| association of a polymorphism in the lipin 1 gene with systolic blood pressure in men. | lipin 1 plays a role in abdominal obesity, insulin resistance, and hypertriglyceridemia. the gene is located at 2p25.1, a susceptibility locus for hypertension. we studied the association of tagging single-nucleotide polymorphisms (snps) in the lipin 1 (lpin1) gene with hypertension and blood pressure. | 2008 | 18437145 |
| macrobenthic communities in a sub-tropical man-made mudflat. | 2008 | 18442834 | |
| cross-sectional and longitudinal factors predicting influenza vaccination in hong kong chinese elderly aged 65 and above. | the study investigated cross-sectional predictors of ever-undergone influenza vaccination (iv) and longitudinal predictors of first-time iv among chinese elderly in hong kong. | 2008 | 18442855 |
| folkbiology meets microbiology: a study of conceptual and behavioral change. | health education can offer a valuable window onto conceptual and behavioral change. in study 1, we mapped out 3rd-grade chinese children's beliefs about causes of colds and flu and ways they can be prevented. we also explored older adults' beliefs as a possible source of the children's ideas. in study 2, we gave 3rd- and 4th-grade chinese children either a conventional cold/flu education program or an experimental "think biology" program that focused on a biological causal mechanism for cold/flu ... | 2008 | 18457822 |
| preliminary findings of a randomized trial of non-pharmaceutical interventions to prevent influenza transmission in households. | there are sparse data on whether non-pharmaceutical interventions can reduce the spread of influenza. we implemented a study of the feasibility and efficacy of face masks and hand hygiene to reduce influenza transmission among hong kong household members. | 2008 | 18461182 |
| implication of genetic variants near tcf7l2, slc30a8, hhex, cdkal1, cdkn2a/b, igf2bp2, and fto in type 2 diabetes and obesity in 6,719 asians. | recent genome-wide association studies have identified six novel genes for type 2 diabetes and obesity and confirmed tcf7l2 as the major type 2 diabetes gene to date in europeans. however, the implications of these genes in asians are unclear. | 2008 | 18469204 |
| the sars-associated stigma of sars victims in the post-sars era of hong kong. | this article explores the disease-associated stigma attached to the sars victims in the post-sars era of hong kong. i argue that the sars-associated stigma did not decrease over time. based on the ethnographic data obtained from 16 months of participant observation in a sars victims' self-help group and semistructured interviews, i argue that the sars-associated stigma was maintained, revived, and reconstructed by the biomedical encounters, government institutions, and public perception. i also ... | 2008 | 18503014 |
| against the odds or odds-on chance: pathways of coming back among hand-injured workers in the chinese context. | in this study, i used a hermeneutic phenomenological approach by means of thematic analysis to examine the lived experiences of hand-injured workers in hong kong. twenty-seven informants with moderate to severe disabilities were interviewed over ten years about how they lived through their disability and their discourses were examined in the cultural context. three categories (survivors, achievers, strugglers) were synthesized from the informants' life courses. each category was analyzed under t ... | 2008 | 18503025 |
| disaster preparedness among hong kong nurses. | this paper is a report of a survey to explore hong kong nurses' disaster preparedness. | 2008 | 18503654 |
| lrrk2 gly2385arg mutation and clinical features in a chinese population with early-onset parkinson's disease compared to late-onset patients. | the frequency of lrrk2 gly2385arg mutation in hong kong chinese with early-onset (age < or =45 years) parkinson's disease was identified and compared with late-onset patients (age >50 years) and controls. the mutation prevalence were 8.8, 8.3, and 0% for early-onset, late-onset, and controls, respectively. the mean age of onset among lrrk2 g2385r carriers was 42.7 years old for early-onset compared to 74.3 for late-onset patients. lrrk2 g2385r mutation appears to be as prevalent among early-onse ... | 2008 | 18523722 |
| warming earth could face new flu, disease threats. | 2008 | 18541678 | |
| evaluating narrative pedagogy in nursing education in hong kong. | this column provides a report of the effectiveness of a nursing program in hong kong that used narrative pedagogy. the comments of 12 recent graduates from a postgraduate baccalaureate nursing degree program who were willing to participate in a series of focus group meetings were included. the findings show that nursing education based on a human science paradigm helped form the professional nursing identity of the graduates, as they continued retelling, reliving, and reflecting on their caring ... | 2008 | 18544790 |
| novel astroviruses in insectivorous bats. | bats are increasingly recognized to harbor a wide range of viruses, and in most instances these viruses appear to establish long-term persistence in these animals. they are the reservoir of a number of human zoonotic diseases including nipah, ebola, and severe acute respiratory syndrome. we report the identification of novel groups of astroviruses in apparently healthy insectivorous bats found in hong kong, in particular, bats belonging to the genera miniopterus and myotis. astroviruses are impo ... | 2008 | 18550669 |
| extended parallel process model and h5n1 influenza virus. | this study integrated the extended parallel process model and forewarning cues to assess the promotion of preventive measures against the h5n1 influenza virus, a significant health threat that affects asia, europe, and the usa. there are two types of forewarning, (1) telling the audience that they will hear messages intended to persuade them and (2) telling the audience the topic and stance of the impending persuasive message. analysis of ratings by 265 undergraduates indicated that forewarnings ... | 2008 | 18567223 |
| environmental health and safety of chinese sex workers: a cross-sectional study. | this paper presents a hong kong (hk) data on the effect that sex work has on women's environmental health and safety. an outreach role that highlights safety and human rights is suggested for nurses working with female sex workers (fsws) as clients. | 2008 | 17475266 |
| surveillance programme for hepatocellular carcinoma improves the survival of patients with chronic viral hepatitis. | the survival benefit of surveillance for hepatocellular carcinoma (hcc) is controversial. aim: we aimed to examine the survival benefit of hcc surveillance in chronic viral hepatitis. | 2008 | 17900247 |
| an exploratory method for estimating the changing speed of epidemic waves from historical data. | historical data are necessary to establish long-term trends in disease incidence but pose analytical problems since their accuracy and reliability may be poorly specified. | 2008 | 18056121 |
| association of f11 receptor gene polymorphisms with central obesity and blood pressure. | f11 receptor, also known as junctional adhesion molecule-1, in the autonomic nervous system is implicated in the development of hypertension in spontaneous hypertensive rats. we investigated the association of single nucleotide polymorphisms (snps) in the f11 receptor gene (f11r) with hypertension and central obesity in hong kong chinese. | 2008 | 18067551 |
| synchrony of clinical and laboratory surveillance for influenza in hong kong. | consultation rates of influenza-like illness (ili) in an outpatient setting have been regarded as a good indicator of influenza virus activity in the community. as ili-like symptoms may be caused by etiologies other than influenza, and influenza virus activity in the tropics and subtropics is less predictable than in temperate regions, the correlation between of ili and influenza virus activity in tropical and subtropical regions is less well defined. | 2008 | 18167558 |
| learning from the severe acute respiratory syndrome (sars) epidemic. | this study uses two models of nursing practice, conventional and modular design, to compare nursing activities, hand hygiene, time efficiency and nurse-patient satisfaction in medical and surgical wards. background. learning from the sars epidemic pointed to the importance of quality nursing practice considerations that minimize cross-transmission of infection while maximizing patient-focused care. hence, a modular nursing model was adopted. | 2008 | 18179533 |
| [influenza, quo vadis?]. | 2008 | 18204106 | |
| impact of severe acute respiratory syndrome and the perceived avian influenza epidemic on the increased rate of influenza vaccination among nurses in hong kong. | to determine the rate of influenza vaccination and the factors associated with the vaccination's acceptance among nurses in hong kong. | 2008 | 18205529 |
| hong kong enrolled nurses' perceptions of spirituality and spiritual care. | to explore hong kong nurses' perceptions of spirituality and spiritual care, and to investigate the relationship between their perceptions and their demographic characteristics. | 2008 | 19522951 |
| melamine-tainted milk product (mtmp) renal stone outbreak in humans. | 2008 | 19060339 | |
| antiviral activities of extracts from hong kong seaweeds. | we extracted six hong kong brown seaweed species with hot water for their antiviral properties. the cytotoxicity and antiviral activity of these extracts were tested by mtt [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenlytetrezolium bromide] method, cytopathic effect reduction assay, and plaque reduction assay. the antiviral effect was further determined by flow cytometric analysis. the results showed that most of these extracts inhibited the propagation of herpes simplex virus types 1 and 2 (hsv-1 an ... | 2008 | 19067465 |
| a study of the health and economic effects of influenza-like illness on the working population under different working environments of a large corporation in hong kong. | the incidence, health and economic impacts of influenza-like illness (ili) among the working population in hong kong had never been studied. due to the nature of the disease, ilis can have a significant impact on the operation of a corporation in terms of loss of productivity and reduced work performance. the present study was undertaken to determine the health and economic impacts of ilis under different environmental conditions on the working population of a large corporation. | 2008 | 19450073 |
| evaluation of loxl1 polymorphisms in primary open-angle glaucoma in southern and northern chinese. | the lysyl oxidase-like protein 1 (loxl1) gene is strongly associated with exfoliation glaucoma, which is very rare in the chinese population. the implicated loxl1 polymorphisms have not been associated with primary open-angle glaucoma (poag). in this study, we investigated three of the loxl1 polymorphisms in poag in a southern chinese population of hong kong and northern chinese from beijing. | 2008 | 19098994 |
| an experience on wheelchair bank management. | in this article, we described the wheelchair bank program at a local hospital and our experiences in managing the service over the past 10 years from 1996 to 2005. this article also reported statistical information related to the acquisitions of wheelchairs and adaptive components, including body support and pressure relief systems. the cost benefit of recycling seating and mobility equipments for use by children with neuromuscular diseases was revealed. with the reference of the reported data, ... | 2008 | 19117190 |
| epidemiology of human papillomavirus infection and cervical cancer and future perspectives in hong kong, singapore and taiwan. | hong kong, singapore and taiwan are three island states that are newly emerged affluent economic areas in asia. the majority of the populations are ethnically chinese with a total population of 6.98, 4.5 and 23 million, respectively. cervical cancer has been declining over the last thirty years in all three states and is largely attributable to widespread opportunistic cervical cancer screening. the age-standardized incidence rates of cervical cancer are 9.6 per 100,000 women in hong kong in 200 ... | 2008 | 18945415 |
| modulation of steroidogenesis by coastal waters and sewage effluents of hong kong, china, using the h295r assay. | the presence of a variety of pollutants in the aquatic environment that can potentially interfere with the production of sex steroid hormones in wildlife and humans has been of increasing concern. the aim of the present study was to investigate the effects of extracts from hong kong marine waters, and influents and effluents from wastewater treatment plants on steroidogenesis using the h295r cell bioassay. after exposing h295r cells to extracts of water, the expression of four steroidogenic gene ... | 2008 | 18493807 |
| theory of mind development in chinese children: a meta-analysis of false-belief understanding across cultures and languages. | theory of mind is claimed to develop universally among humans across cultures with vastly different folk psychologies. however, in the attempt to test and confirm a claim of universality, individual studies have been limited by small sample sizes, sample specificities, and an overwhelming focus on anglo- european children. the current meta-analysis of children's false-belief performance provides the most comprehensive examination to date of theory-of-mind development in a population of non-weste ... | 2008 | 18331141 |
| gender difference in achieving rate of maturity of the vesicoureteric junction. | our previous study on the doppler waveform of the urinary jet at the vesicoureteric junction (vuj) indicates that there is an active sphincteric mechanism in humans. we have also shown that there are immature and mature patterns of the jet, and the vuj matures around the age of 4 years. | 2007 | 17180364 |
| chinese widowers' self-perception of growth: an exploratory study. | presence of growth after traumatic events was introduced to the academic community about a decade ago (tedeschi & calhoun, 1995). from the conventionally neglected perspective of chinese widowers, this paper reports seventeen chinese widowers' views on growth after conjugal loss. findings seem to suggest that chinese widowers would define growth as human learning, a definition probably influenced by confucian teachings. furthermore, contrary to claims made by tedeschi and calhoun (2004), it was ... | 2007 | 18928081 |
| prenatal influenza exposure and delivery complications: implications for the development of schizophrenia. | this study assessed prenatal influenza exposure in relation to pregnancy complications and delivery complications. participants of this study consisted of a community sample of all mothers of 1,795 children who were a birth cohort recruited at age 3 in a prospective longitudinal project in mauritius. the onset of the 1968-1972 a2/hong kong influenza epidemic in january 1970 was established from officially published death rates and newspaper records. data on pregnancy and delivery complications w ... | 2007 | 19241651 |
| live poultry exposures, hong kong and hanoi, 2006. | since 1997, the largest epidemic of highly pathogenic avian influenza (h5n1) ever recorded has caused 172 human and several billion bird deaths. recently administered questionnaires determined that live poultry exposures have declined by approximately 63% in hong kong since 2004 and that, in vietnam, domestic backyard exposures to poultry are likely more important than retail exposures. | 2007 | 18214181 |
| co-circulation of human metapneumovirus and sars-associated coronavirus during a major nosocomial sars outbreak in hong kong. | the clinico-epidemiological significance of human metapneumovirus (hmpv) detected during the sars outbreak is unknown. | 2007 | 17936066 |
| cyclic peptides from an endophytic fungus obtained from a mangrove leaf (kandelia candel). | two new cyclic depsipeptides, 1962a (1) and 1962b (2), along with the three known cyclodipeptides cyclo-(leu-tyr) (3), cyclo-(phe-gly) (4), and cyclo-(leu-leu) (5) were isolated from the fermentation broth of the mangrove endophytic fungus (no. 1962) isolated from an old leaf of kandelia candel collected in hong kong. through spectroscopic experimentation, x-ray crystallographic analysis, and acid hydrolysis followed by chiral hplc analysis, their structures were established to be 1962a, cyclo-( ... | 2007 | 17944538 |
| neurologic complications in children hospitalized with influenza: comparison between usa and hong kong. | 2007 | 17961673 | |
| rhinovirus infection in hospitalized children in hong kong: a prospective study. | to analyze the clinical features and estimate the hospitalization disease burden of rhinovirus infection in children in hong kong. | 2007 | 17984805 |
| theoretically estimated risk of severe acute respiratory syndrome transmission through blood transfusion during an epidemic in shenzhen, guangdong, china in 2003. | severe acute respiratory syndrome (sars) is a newly recognized infectious disease that caused an outbreak in south china in 2003. the cause of sars was identified as a novel coronavirus (cov). the existence of asymptomatic seroconvertors and the detection of the sars-cov rna in plasma during the course of infection all suggest that sars could, as least theoretically, be transmitted by transfusion. an estimate of the risk of sars transmission through blood transfusion will contribute to decisions ... | 2007 | 18036985 |
| iodine nutrition of pregnant and lactating women in hong kong, where intake is of borderline sufficiency. | to describe the iodine nutrition of pregnant and lactating women in hong kong, where intake is of borderline sufficiency. | 2007 | 18053285 |
| a qualitative study on the comfort and fit of ladies' dress shoes. | the perceived differences between comfortable and uncomfortable shoes and the fit preferences in the different regions of ladies' shoes were explored. twenty hong kong chinese females participated in the study. each participant wore and rated the different aspects of their own comfortable and uncomfortable shoes. the wilcoxon signed rank tests showed significant differences in ten perceived characteristics between the comfortable and uncomfortable shoes. among the ten were tactile, auditory and ... | 2007 | 17353001 |
| anticipated and current preventive behaviors in response to an anticipated human-to-human h5n1 epidemic in the hong kong chinese general population. | the prevalence of self-reported preventive behaviors in response to an anticipated local human-to-human h5n1 transmission outbreak and factors associated with such behaviors have not been examined. | 2007 | 17359545 |
| vitamin d receptor 3' haplotypes are unequally expressed in primary human bone cells and associated with increased fracture risk: the mros study in sweden and hong kong. | the vdr is a prime candidate gene for osteoporosis. here, we studied three common vdr haplotypes in relation to bone phenotypes in 5014 participants of the global mros study. we also studied the relative expression of the haplotypes in human bone cells. one haplotype was associated with increased fracture risk and differently expressed in primary human bone cells. | 2007 | 17371163 |
| first-trimester combined screening for trisomy 21 in a predominantly chinese population. | to examine the effectiveness of first-trimester fetal trisomy 21 screening using a combination of maternal age, nuchal translucency thickness (nt) and maternal serum free beta-human chorionic gonadotropin (beta-hcg) and pregnancy-associated plasma protein-a (papp-a) levels in a predominantly chinese population in hong kong. | 2007 | 17171632 |
| evaluation of an in-house genotyping resistance test for hiv-1 drug resistance interpretation and genotyping. | the human immunodeficiency virus type 1 (hiv-1) genotyping resistance test (grt) has been considered essential for hiv-1 drug resistance monitoring. however, it is not commonly used in some developing countries in asia and africa due to its high running cost. | 2007 | 17449318 |
| new evidence for geographic variation in the role of human papillomavirus in tonsillar carcinogenesis. | our previous studies of tonsillar cancers from new south wales, australia, and jilin province in the north-east of china, provided evidence that the proportion of these cancers attributable to human papillomavirus (hpv) varies geographically. this study provides the first data on hpv in tonsillar cancers from hong kong. | 2007 | 17454751 |
| any effect of cyp2c9 variants on warfarin clearance in chinese patients? | 2007 | 17479200 | |
| association between hla-b*1502 allele and antiepileptic drug-induced cutaneous reactions in han chinese. | a previous study conducted in taiwan found a 100% association between hla-b*1502 allele and carbamazepine-induced stevens-johnson syndrome (sjs) in han chinese subjects, with an extremely high odds ratio compared with carbamazepine-tolerant subjects (odds ratio = 2,504). we examined this association in 24 hong kong han chinese subjects who had cutaneous adverse reactions induced by different antiepileptic drugs (aeds). they were matched with 48 aed-tolerant controls. hla-b*1502 was associated wi ... | 2007 | 17509004 |
| association between hla-drb1 polymorphism, high-risk hpv infection and cervical neoplasia in southern chinese. | multiple determinants are involved in the progression of human papillomavirus (hpv)-infected cervical lesion to invasive cancer. human leukocyte antigen (hla) polymorphism seems to play a role. this study examined the association between hla-drb1 polymorphism, high-risk hpv infection, and the development of cervical neoplasia in southern chinese. three hundred and seventy women with cervical neoplasia (43 cervical intraepithelial neoplasia grade ii, 154 grade iii, and 173 invasive cancers) and 3 ... | 2007 | 17516530 |
| anthropometric evaluation for primary school furniture design. | musculoskeletal symptoms are one of the top ten health problems among schoolchildren in hong kong. whether or not these symptoms are related to school furniture has yet to be determined and published data on furniture size are lacking. the purpose of the study was to determine whether the design of furniture in schools is appropriate for children's anthropometry. a total of 214 volunteer subjects were recruited. this constituted 90% of the total number of primary 5 and 6 students in the studied ... | 2007 | 17536771 |
| universal antenatal human immunodeficiency virus (hiv) testing programme is cost-effective despite a low hiv prevalence in hong kong. | to evaluate the cost-effectiveness of universal antenatal human immunodeficiency virus (hiv) testing in hong kong. | 2007 | 17548908 |
| non-typhoid salmonella mycotic aneurysm of the aortic arch. | salmonella mycotic aneurysm is a rare but potentially fatal condition. mortality is high without timely intervention. the clinical presentation is protean and early diagnosis requires a high degree of clinical alertness. prompt surgical intervention and prolonged antimicrobial therapy are keys to successful treatment. we report an 81-year-old man with an atypical presentation of salmonella mycotic aneurysm in the aortic arch. the case highlights the need to evaluate all patients over 50 years wi ... | 2007 | 17548914 |
| patients with malignant or pre-malignant cervical lesion have increased risk of becoming hepatitis b carrier. | human papillomavirus (hpv) and hepatitis b virus (hbv) are known aetiology of cervical and hepatocellular carcinoma, respectively. both diseases share a similar clinical course, that is, the vast majority of those infected by these two viruses can eradicate the viruses spontaneously. a small sub-group who fails to clear the virus becomes chronic carrier and can progress to carcinoma many years later. we postulated that patients with pre-malignant or malignant cervical lesion are at increased ris ... | 2007 | 17550135 |
| deductive reasoning and creativity: a cross-cultural study. | the present cross-cultural study examined the relationship between deductive reasoning and creativity among college students (m age=20.4 yr., sd= .6) from hong kong (n=39) and the united states (n=38). participants performed tasks designed to measure deductive reasoning, creative writing, and insight problem-solving, all in verbal form. no correlation was found between the performance for deductive reasoning and creativity as measured by creative writing. insight problem-solving performance corr ... | 2007 | 17564227 |
| long-term results of allogeneic bone marrow transplantation for 108 adult patients with acute lymphoblastic leukemia: favorable outcome with bmt at first remission and hla-matched unrelated donor. | we analyzed the outcome of 108 adult acute lymphoblastic leukemia patients undergoing allogeneic bone marrow transplantation (bmt). philadelphia (ph) chromosome occurred in 35.2% patients at diagnosis. two-thirds of patients received allogeneic bmt in first complete remission (cr1) bmt. salvage bmt was performed in 21 and 16 patients at second complete remission (cr2) and beyond cr2. donors were human leukocyte antigen-identical siblings in 87 patients, and match-unrelated donors in 21 patients. ... | 2007 | 17572712 |
| variants conferring risk of atrial fibrillation on chromosome 4q25. | atrial fibrillation (af) is the most common sustained cardiac arrhythmia in humans and is characterized by chaotic electrical activity of the atria. it affects one in ten individuals over the age of 80 years, causes significant morbidity and is an independent predictor of mortality. recent studies have provided evidence of a genetic contribution to af. mutations in potassium-channel genes have been associated with familial af but account for only a small fraction of all cases of af. we have perf ... | 2007 | 17603472 |
| emerging occupational lung infections. | recent experiences of emerging infections, such as severe acute respiratory syndrome (sars) and avian influenza (h5n1), have highlighted the risks of serious pulmonary infections from occupational exposures. occupationally acquired human immunodeficiency virus (hiv) infection could also result in life-threatening, opportunistic lung infections as a result of host immunosuppression. these three occupationally acquired infections are major public health problems that carry with them enormous econo ... | 2007 | 17609045 |
| replication and identification of novel variants at tcf7l2 associated with type 2 diabetes in hong kong chinese. | variations at a large linkage disequilibrium (ld) block of transcription factor 7-like 2 gene (tcf7l2) were reported to be associated with type 2 diabetes (t2d) in icelandic, danish and european-american populations and further replicated in other populations of european, african, and asian ancestries. however, data for chinese and comprehensive survey of the whole gene are lacking. | 2007 | 17609304 |
| agreement between breast milk dioxin levels by calux bioassay and chemical analysis in a population survey in hong kong. | chemically-activated luciferase gene expression (calux) bioassay and gas chromatography/mass spectrometry (gc/ms) are used to determine dioxin levels in food and humans. valid measures of the agreement between the two methods would improve interpretation of bioassay results. paired breast milk samples from 250 mothers, as 11 pooled samples, were analysed by gc/ms for total who-teq (7 polychlorinated dibenzo-para-dioxins, 10 polychlorinated dibenzofurans and 12 dioxin-like polychlorinated bipheny ... | 2007 | 17618674 |
| spatial distribution of heavy metals in hong kong's marine sediments and their human impacts: a gis-based chemometric approach. | a geographic information system (gis)-based chemometric approach was applied to investigate the spatial distribution patterns of heavy metals in marine sediments and to identify spatial human impacts on global and local scales. twelve metals (zn, v, ni, mn, pb, cu, cd, ba, hg, fe, cr and al) were surveyed twice annually at 59 sites in hong kong from 1998 to 2004. cluster analysis classified the entire coastal area into three areas on a global scale, representing different pollution levels. backw ... | 2007 | 17624377 |
| molecular analysis of a chromosome 4 inversion segregating in a large schizophrenia kindred from hong kong. | the present study looks at a paracentric inversion on chromosome 4 [inv(4)(q13;q25)] in members of a large schizophrenia kindred from hong kong, and the possibility of a susceptibility gene for schizophrenia at one of the inversion breakpoints. fluorescence in situ hybridization with bac and fosmid clones was used to determine the location of the 4q13 and 4q25 breakpoints, however bioinformatic analysis indicated that no known genes are directly disrupted by the breakpoints. we identified severa ... | 2007 | 17644315 |
| women's attitudes on human papillomavirus vaccination to their daughters. | this study assessed the impact of an information pamphlet on acceptance of human papillomavirus (hpv) vaccine in chinese women. the pamphlet increased the self-perceived knowledge on cervical cancer and hpv of the study subjects and had a positive influence on women accepting hpv vaccination for their daughters (p < .001). | 2007 | 17659226 |
| the potential impact of a prophylactic vaccine for human papillomavirus on the current cervical screening programme in hong kong. | to review and summarise current controversies in cervical screening in hong kong and discuss the potential impact of prophylactic human papillomavirus vaccination. | 2007 | 17664535 |
| factors associated with early hospital discharge of adult influenza patients. | understanding factors affecting length of hospital stay (los) in patients with severe influenza may improve their management. | 2007 | 17668558 |
| profile of viral load, integration, and e2 gene disruption of hpv58 in normal cervix and cervical neoplasia. | the clinical utility of viral-load and integration status of human papillomavirus (hpv) infection remains uncertain. we examined 75 women infected with hpv58, a worldwide rare type found to be prevalent in cervical cancers in eastern asia. viral load was significantly higher for cervical intraepithelial neoplasia (cin) 1/2, but those for a normal control group and for cin 3 or cancer overlapped substantially. a pure integrated genome was found for all lesion grades, giving a poor positive predic ... | 2007 | 17703417 |
| beliefs about cervical cancer and human papillomavirus (hpv) and acceptability of hpv vaccination among chinese women in hong kong. | to assess the knowledge and beliefs on cervical cancer and hpv infection and to evaluate the acceptability of hpv vaccination among chinese women. | 2007 | 17707077 |
| isolation of laribacter hongkongensis, a novel bacterium associated with gastroenteritis, from drinking water reservoirs in hong kong. | freshwater fish has been found to be the reservoir of laribacter hongkongensis, a recently discovered bacterium associated with community-acquired gastroenteritis. however, little is known about the ecology of this bacterium in the aquatic environment. we carried out a surveillance study to investigate the presence of l. hongkongensis in water and freshwater fish from 10 drinking water reservoirs in hong kong. | 2007 | 17714383 |
| clinical and molecular epidemiology of human bocavirus in respiratory and fecal samples from children in hong kong. | human bocavirus (hbov) is a recently discovered parvovirus associated with respiratory tract infections in children. we conducted the first systematic prospective clinical and molecular study using nasopharyngeal aspirates (npas) and fecal samples. | 2007 | 17763318 |
| comparison of two automated nucleic acid testing systems for simultaneous detection of human immunodeficiency virus and hepatitis c virus rna and hepatitis b virus dna. | recently developed nucleic acid testing (nat) assays incorporating simultaneous detection of human immunodeficiency virus (hiv), hepatitis c virus (hcv), and hepatitis b virus (hbv) have made hbv nat screening more feasible for blood services. this study compared the performance of two "multiplex" nat assays and their automated testing platforms. | 2007 | 17880602 |
| impact of sars on avian influenza preparedness in healthcare workers. | sars was an unprecedented outbreak which brought about 1,755 infections and 302 deaths in hong kong. the similarity of sars and avian influenza prompted us to examine the relationship between sars experience and preparedness on a potential avian influenza outbreak. | 2007 | 17882357 |
| comparing the magnitude of discriminatory attitudes toward people living with hiv/aids and toward people with mental illness in the hong kong general population. | the study compared the level of discriminatory attitudes toward people living with human immunodeficiency virus (hiv)/acquired immune deficiency syndrome (aids) (plwha) and people with mental illness (pmi) and investigated factors associated with the absolute and relative levels of these discriminatory attitudes. an anonymous cross-sectional telephone survey interviewed 604 chinese adults aged 18-50 years from the general hong kong population. discriminatory attitudes toward both groups are prev ... | 2007 | 16849388 |
| residual levels of ddts and pahs in freshwater and marine fish from hong kong markets and their health risk assessment. | axial and ventral muscle from 10 each species of freshwater and marine fish purchased from markets in hong kong were analyzed for dichlorodiphenyltrichloroethane (total ddts including dde, ddd and ddt) and polycyclic aromatic hydrocarbons (pahs). among the 10 freshwater fish species, rice field eel (monopterus albus) showed significantly higher levels of ddts in both ventral (125 ng/g wet wt) and axial muscle (127 ng/g wet wt) than the other species. the highest concentration of pahs was detecte ... | 2007 | 16870232 |
| real-time epidemic forecasting for pandemic influenza. | the ongoing worldwide spread of the h5n1 influenza virus in birds has increased concerns of a new human influenza pandemic and a number of surveillance initiatives are planned, or are in place, to monitor the impact of a pandemic in near real-time. using epidemiological data collected during the early stages of an outbreak, we show how the timing of the maximum prevalence of the pandemic wave, along with its amplitude and duration, might be predicted by fitting a mass-action epidemic model to th ... | 2007 | 16928287 |
| risk assessment of trace elements in the stomach contents of indo-pacific humpback dolphins and finless porpoises in hong kong waters. | the potential health risks due to inorganic substances, mainly metals, was evaluated for the two resident marine mammals in hong kong, the indo-pacific humpback dolphin (sousa chinensis) and the finless porpoise (neophocaena phocaenoides). the stomachs from the carcasses of twelve stranded dolphins and fifteen stranded porpoises were collected and the contents examined. concentrations of thirteen trace elements (ag, as, cd, co, cr, cs, cu, hg, mn, ni, se, v and zn) were determined by inductively ... | 2007 | 16979696 |
| identification of molecular markers and signaling pathway in endometrial cancer in hong kong chinese women by genome-wide gene expression profiling. | endometrial cancer is the third most common gynecologic malignancy and the ninth most common malignancy for females overall in hong kong. approximately 80% or more of these cancers are endometrioid endometrial adenocarcinomas. the aim of this study was to reveal genes contributing to the development of endometrioid endometrial cancer, which may impact diagnosis, prognosis and treatment of the disease. whole-genome gene expression analysis was completed for a set of 55 microdissected sporadic end ... | 2007 | 17043662 |
| pollutants in hong kong soils: polycyclic aromatic hydrocarbons. | an extensive soil survey was carried out to study the polycyclic aromatic hydrocarbon (pah) contaminations in 138 soil samples collected throughout hong kong. results demonstrated that there were low levels of pah contaminations (median of summation operator 16us epa pahs=140 microg kg(-1)) for all land uses (urban park, greening area, country park, rural area, restored landfill, agricultural farmland, orchard farm, crematorium, industrial and near highway area). however, localized hotspots were ... | 2007 | 17109918 |
| evaluation of nuclisens easyq hiv-1 assay for quantification of hiv-1 subtypes prevalent in south-east asia. | monitoring anti-retroviral therapy requires that viral load assays for human immunodeficiency virus type 1 (hiv-1) be applicable to diverse hiv-1 subtypes. | 2007 | 17110162 |
| characterizing 56 complete sars-cov s-gene sequences from hong kong. | the spike glycoprotein (s) gene of the severe acute respiratory syndrome-associated coronavirus (sars-cov) has been useful in analyzing the molecular epidemiology of the 2003 sars outbreaks. | 2007 | 17112780 |
| catabacter hongkongensis gen. nov., sp. nov., isolated from blood cultures of patients from hong kong and canada. | four bacterial isolates were recovered from the blood cultures of four patients, two of whom were from hong kong and two of whom were from canada. the two hong kong strains were isolated from a 48-year-old man with intestinal obstruction and secondary sepsis (strain hku16t) and from a 39-year-old man with acute appendicitis (strain hku17), while the two canadian strains were isolated from a 74-year-old man with biliary sepsis (strain ca1) and from a 66-year-old woman with metastatic carcinoma an ... | 2007 | 17122022 |
| the study of sequence configuration and functional impact of the (ac)n(at)xty motif in human beta-globin gene promoter. | in this report we examine the (ac)n(at)xty motif residing -530 bp 5' upstream of the beta-globin gene in chinese thalassaemic patients. this motif is a putative binding site for a repressor protein, termed beta protein 1 (bp1) (berg et al., nucleic acids res 1989;17:8833-8852). variations in the (ac)n(at)xty repeats affect the binding affinity of bp1, thereby altering the expression of the beta-globin gene. eight different configurations of this repeat motif are identified in our population of c ... | 2007 | 17133428 |
| tropism of avian influenza a (h5n1) in the upper and lower respiratory tract. | poor human-to-human transmission of influenza a h5n1 virus has been attributed to the paucity of putative sialic acid alpha2-3 virus receptors in the epithelium of the human upper respiratory tract, and thus to the presumed inability of the virus to replicate efficiently at this site. we now demonstrate that ex vivo cultures of human nasopharyngeal, adenoid and tonsillar tissues can be infected with h5n1 viruses in spite of an apparent lack of these receptors. | 2007 | 17206149 |
| phenotypic and population differences in the association between cilp and lumbar disc disease. | lumbar disc disease (ldd) is one of the leading causes of disability in the working-age population. a functional single-nucleotide polymorphism (snp), +1184t-->c, in exon 8 of the cartilage intermediate layer protein gene (cilp) was recently identified as a risk factor for ldd in the japanese population (odds ratio (or) 1.61, 95% ci 1.31 to 1.98), with implications for impaired transforming growth factorbeta1 signalling. | 2007 | 17220213 |
| alternative methods of estimating an incubation distribution: examples from severe acute respiratory syndrome. | accurate and precise estimates of the incubation distribution of novel, emerging infectious diseases are vital to inform public health policy and to parameterize mathematical models. | 2007 | 17235210 |
| cross-border truck drivers in hong kong: their psychological health, sexual dysfunctions and sexual risk behaviors. | due to their job nature, cross-border truck drivers working between hong kong and china are exposed to many health risks. the aim of this study was to find out the impact of their occupation on their psychological health and sexual dysfunction and to assess their sexual risk behaviors. | 2007 | 17241250 |
| deficiency of mannan-binding lectin associated serine protease-2 due to missense polymorphisms. | mannan-binding lectin (mbl) and ficolins distinguish between self, non-self and altered-self by recognizing patterns of ligands on the surface of microorganisms or aberrant cells. when this happens mbl-associated serine protease-2 (masp-2) is activated and cleaves complement factors to start inflammatory actions. we examined human populations for masp-2 levels, masp-2 function and for the presence of mutations in coding exons of masp2. the masp-2 levels were lowest in africans from zambia (media ... | 2007 | 17252003 |
| perceptions related to human avian influenza and their associations with anticipated psychological and behavioral responses at the onset of outbreak in the hong kong chinese general population. | anticipated psychological responses and perceptions of risk have not been examined prior to the outbreak of an epidemic. | 2007 | 17276790 |
| olanzapine-induced diabetic ketoacidosis in a chinese man. | we present a case report of a 22-year-old chinese man with schizophrenia and dissocial personality disorder who was normoglycaemic before taking olanzapine. after commencing olanzapine he developed diabetic ketoacidosis and was managed in the intensive care unit of a general hospital. olanzapine was stopped and replaced by haloperidol 5 mg/day. he was put on a strict 1500 kcal diabetic diet and required insulin injections to maintain a normal blood sugar level despite cessation of olanzapine for ... | 2007 | 17277396 |
| trace metals and organochlorines in the bamboo shark chiloscyllium plagiosum from the southern waters of hong kong, china. | the bamboo shark chiloscyllium plagiosum is an abundant benthic species along the shallow continental shelf of southeast asia. it is commonly taken by fishermen in china, india, taiwan and thailand for human consumption. this study measured trace metal and organochlorine concentrations in c. plagiosum collected from the southern waters of hong kong, china. metals (ag, cd, cr, cu, mn, ni, pb and zn) were measured in three different tissues: dorsal muscle, spleen and liver. polychlorinated bipheny ... | 2007 | 17320935 |
| studies on the expression of the deleted kir2ds4*003 gene product and distribution of kir2ds4 deleted and nondeleted versions in different populations. | a kir2ds4 deletion variant allele, previously identified through killer immunoglobulinlike receptor (kir) polymerase chain reaction-sequence-specific oligonucleotide probe (pcr-ssop) typing, was functionally investigated using an in vitro cell line model system and in vivo protein expression studies. the kir2ds4 deletion variant has previously been found in 80% of individuals from northern ireland, indicating that it is present at a high incidence in this population. it differs from the normal k ... | 2007 | 17321903 |
| a fatal case of chromobacterium violaceum septicemia in hong kong. | chromobacterium violaceum causes a rare infection in human, usually in tropical or subtropical areas. we report a fatal case of c. violaceum infection affecting a 40-year-old previously healthy man in hong kong. he presented with a wound infection and lymphadenitis. despite multiple antibiotic treatment, including ciprofloxacin, he succumbed shortly after admission to the hospital. we report the epidemiological investigation findings and discuss the possible sources of infection. physicians shou ... | 2006 | 17333774 |
| human papillomavirus dna and liquid-based cervical cytology cotesting in screening and follow-up patient groups. | to compare the use of human papillomavirus (hpv) dna and cervical cytology cotesting in screening and follow-up of patients with previous cervical abnormalities and to assess the significance of a positive hpv dna test result in re-screening of cytologically normal cases. | 2006 | 17152273 |
| bioinformatics research on the sars coronavirus (sars_cov) in china. | severe acute respiratory syndrome (sars) first appeared in 2002 in china, which fastly affected about 8000 patients over 29 countries and caused 774 fatalities. as its pathogen was identified as a new kind of coronavirus (sars_cov), its genome was quickly sequenced on several isolates. studies on its functional genomics were performed by combinatorial application of all the available bioinformatics tools and the development of new programs. in this way, it was found that the four proteins were a ... | 2006 | 17168762 |
| social competence as a positive youth development construct: conceptual bases and implications for curriculum development. | two major aspects of social competence were studied in this section: positive human relationships and clear self-identity. the concepts of human relationships and identity development are delineated. the importance of the development of a national identity for hong kong adolescents is also explained. the social competence program units focus on issues relating to national and racial identity, and human relationships (especially the resolution of interpersonal conflicts in the family and between ... | 2006 | 17068919 |
| human capital, social capital and social exclusion: impacts on the opportunity of households with youth to leave poverty. | based on a sample survey, this paper, analyzes the impact of human capital, social capital and social exclusion on the opportunity of hong kong families with youth members to leave poverty. educational attainment of the youth members and adult family members, as well as the quantity and quality of social networks were found to have significant positive impacts, while social exclusion from the labor market of the adult members was found to have significant negative impact on their opportunity to ... | 2006 | 17068934 |
| viral load, e2 gene disruption status, and lineage of human papillomavirus type 16 infection in cervical neoplasia. | the clinical utility of human papillomavirus (hpv) load and integration status remains unclear. we applied refined methods to delineate the viral load, integration status, and lineage of 104 women with hpv-16 monotype infection, including 19 with normal cervices, 9 with histologically proven cervical intraepithelial neoplasia (cin) 1, 24 with cin 2, 27 with cin 3, and 25 with squamous cell carcinoma (scc). higher crude viral load, as determined by real-time polymerase chain reaction (pcr) target ... | 2006 | 17109343 |
| health professionals and the international code of marketing of breast-milk substitutes. | 2006 | 17028365 | |
| clinical studies of immunomodulatory activities of yunzhi-danshen in patients with nasopharyngeal carcinoma. | nasopharyngeal carcinoma (npc) is a prevalent tumor in hong kong. the immune system of such patients could be adversely affected during the course of conventional chemotherapy or radiotherapy. we investigated the immunomodulatory effects of traditional chinese medicine (tcm) yunzhi-danshen capsules in npc patients treated with radiotherapy. | 2006 | 17034283 |
| the large 386-nt deletion in sars-associated coronavirus: evidence for quasispecies? | the severe acute respiratory syndrome-associated coronavirus (sars-cov) is reported to have deletions of various sizes. recently, the large 386-nucleotide deletion (l386del) comprising nucleotide positions 27719-28104 and spanning open reading frames 9-11 has been reported in the genomes of some human isolates from hong kong. in this study, archived specimens from 71 patients with sars who were admitted to the new territory east cluster hospitals in hong kong were analyzed to determine whether t ... | 2006 | 16941348 |