Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| using expert judgment to estimate marine ecosystem vulnerability in the california current. | as resource management and conservation efforts move toward multi-sector, ecosystem-based approaches, we need methods for comparing the varying responses of ecosystems to the impacts of human activities in order to prioritize management efforts, allocate limited resources, and understand cumulative effects. given the number and variety of human activities affecting ecosystems, relatively few empirical studies are adequately comprehensive to inform these decisions. consequently, management often ... | 2010 | 20666257 |
| rampant drift in artificially fragmented populations of the endangered tidewater goby (eucyclogobius newberryi). | habitat fragmentation and its genetic consequences are a critically important issue in evaluating the evolutionary penalties of human habitat modification. here, we examine the genetic structure and diversity in naturally subdivided and artificially fragmented populations of the endangered tidewater goby (eucyclogobius newberryi), a small fish restricted to discrete coastal lagoons and estuaries in california, usa. we use five naturally fragmented coastal populations from a 300- km spatial scale ... | 2010 | 20666998 |
| the positive role of social networks and social networking technology in the condom-using behaviors of homeless young people. | to examine the impact of condom-using peers in the social networks of homeless young people, differences in behaviors were assessed based on the social location of ties (home-based vs. street-based) and how those ties are maintained (face-to-face vs. via social networking technology). | 2010 | 20597459 |
| a disaster medicine curriculum for medical students. | hospitals are viewed as a haven of safety within a community in the aftermath of a natural or man-made disaster. thus, the importance of disaster training for hospital personnel is paramount. regardless of specialty, all physicians will be called upon to serve. yet, disaster training is not routinely incorporated into the curriculum of undergraduate medical education. the development and implementation of a disaster management course for medical students should therefore be a priority. | 2010 | 20614377 |
| national institute of mental health multisite eban hiv/std prevention intervention for african american hiv serodiscordant couples: a cluster randomized trial. | human immunodeficiency virus (hiv) has disproportionately affected african americans. couple-level interventions may be a promising intervention strategy. | 2010 | 20625011 |
| alcohol consumption and rectal tumor mutations and epigenetic changes. | an association between alcohol and rectal cancer has been reported in the epidemiological literature. in this study we further explore the association by examining specific tumor markers with alcohol consumption as well as types of alcoholic beverages consumed. | 2010 | 20628283 |
| institutional review board challenges related to community-based participatory research on human exposure to environmental toxins: a case study. | we report on the challenges of obtaining institutional review board (irb) coverage for a community-based participatory research (cbpr) environmental justice project, which involved reporting biomonitoring and household exposure results to participants, and included lay participation in research. | 2010 | 20637068 |
| human papillomavirus concordance in heterosexual couples. | few studies have examined the relationships between sexual or hygienic behaviors and human papillomavirus (hpv) transmission. our objectives were to (1) describe hpv concordance between the anogenital, oral, and palmar areas of monogamous heterosexual couples; and (2) determine sexual behaviors, hygienic practices, sexual histories, and subject characteristics associated with hpv anogenital concordance. | 2010 | 20638007 |
| presence of bacteroidales as a predictor of pathogens in surface waters of the central california coast. | the value of bacteroidales genetic markers and fecal indicator bacteria (fib) to predict the occurrence of waterborne pathogens was evaluated in ambient waters along the central california coast. bacteroidales host-specific quantitative pcr (qpcr) was used to quantify fecal bacteria in water and provide insights into contributing host fecal sources. over 140 surface water samples from 10 major rivers and estuaries within the monterey bay region were tested over 14 months with four bacteroidales- ... | 2010 | 20639358 |
| seroprevalence following the second wave of pandemic 2009 h1n1 influenza in pittsburgh, pa, usa. | in april 2009, a new pandemic strain of influenza infected thousands of persons in mexico and the united states and spread rapidly worldwide. during the ensuing summer months, cases ebbed in the northern hemisphere while the southern hemisphere experienced a typical influenza season dominated by the novel strain. in the fall, a second wave of pandemic h1n1 swept through the united states, peaking in most parts of the country by mid october and returning to baseline levels by early december. the ... | 2010 | 20644650 |
| emergence of cryptococcus gattii-- pacific northwest, 2004-2010. | cryptococcus is a genus of fungi, of which two species, cryptococcus neoformans and cryptococcus gattii, cause nearly all human and animal cryptococcal infections. whereas c. neoformans primarily affects persons infected with human immunodeficiency virus (hiv) worldwide, c. gattii primarily affects hiv-uninfected persons in tropical and subtropical regions. in december 2004, a case of human c. gattii infection was reported in oregon, associated with an outbreak on vancouver island and in mainlan ... | 2010 | 20651641 |
| water quality in south san francisco bay, california: current condition and potential issues for the south bay salt pond restoration project. | the sbsprp is an extensive tidal wetland restoration project that is underway at the margin of south san francisco bay, california. the project, which aims to restore former salt ponds to tidal marsh and manage other ponds for water bird support, is taking place in the context of a highly urbanized watershed and an estuary already impacted by chemical contaminants. there is an intimate relationship between water quality in the watershed, the bay, and the transitional wetland areas where the proj ... | 2010 | 20652671 |
| roberts et al. respond to "human cmv, inflammation, and mortality". | 2010 | 20660118 | |
| invited commentary: human cytomegalovirus, inflammation, cardiovascular disease, and mortality. | human cytomegalovirus (cmv) is a human herpesvirus, and infection is widespread in the human population. prevalence of seropositivity for human cmv increases with age. cmv establishes persistent infection in vascular arterial and venous endothelial tissue. it has been associated with atherosclerosis and graft rejection in heart transplant recipients. the antiviral drug ganciclovir prevents cmv disease in heart transplant patients, and valganciclovir and cmv immune globulin reduce rejection rates ... | 2010 | 20660119 |
| bat guano virome: predominance of dietary viruses from insects and plants plus novel mammalian viruses. | bats are hosts to a variety of viruses capable of zoonotic transmissions. because of increased contact between bats, humans, and other animal species, the possibility exists for further cross-species transmissions and ensuing disease outbreaks. we describe here full and partial viral genomes identified using metagenomics in the guano of bats from california and texas. a total of 34% and 58% of 390,000 sequence reads from bat guano in california and texas, respectively, were related to eukaryotic ... | 2010 | 20463061 |
| treatment of ductal carcinoma in situ among patients cared for in large integrated health plans. | to examine whether use of adjuvant therapy varies by race/ethnicity among patients with ductal carcinoma in situ (dcis) at 3 integrated health plan delivery sites based in california and massachusetts. | 2010 | 20469955 |
| lack of sequence variation of the mitochondrial cytochrome b gene from a malaria parasite, plasmodium mexicanum. | very slight sequence differences in the mitochondrial cytochrome b gene, even single nucleotide substitutions, have been proposed as indicative of different species of avian malaria parasites. however, few studies have examined within-species variation in that gene for plasmodium or related genera. we examined sequences for the entire cytochrome b gene from plasmodium mexicanum , a parasite of lizards, for sites where microsatellite markers revealed substantial genetic diversity. for sites where ... | 2010 | 20476806 |
| use of er/pr/her2 subtypes in conjunction with the 2007 st gallen consensus statement for early breast cancer. | the 2007 st gallen international expert consensus statement describes three risk categories and provides recommendations for treatment of early breast cancer. the set of recommendations on how to best treat primary breast cancer is recognized and used by clinicians worldwide. we now examine the variability of five-year survival of the 2007 st gallen risk classifications utilizing the er/pr/her2 subtypes. | 2010 | 20492696 |
| temporal and spatial patterns of ambient endotoxin concentrations in fresno, california. | endotoxins are found in indoor dust generated by human activity and pets, in soil, and adsorbed onto the surfaces of ambient combustion particles. endotoxin concentrations have been associated with respiratory symptoms and the risk of atopy and asthma in children. | 2010 | 20494854 |
| small mammal diversity loss in response to late-pleistocene climatic change. | communities have been shaped in numerous ways by past climatic change; this process continues today. at the end of the pleistocene epoch about 11,700 years ago, north american communities were substantially altered by the interplay of two events. the climate shifted from the cold, arid last glacial maximum to the warm, mesic holocene interglacial, causing many mammal species to shift their geographic distributions substantially. populations were further stressed as humans arrived on the continen ... | 2010 | 20495547 |
| beta-blockers for chest pain associated with recent cocaine use. | although beta-blockers prevent adverse events after myocardial infarction, they are contraindicated when chest pain is associated with recent cocaine use. recommendations against this use of beta-blockers are based on animal studies, small human experiments, and anecdote. we sought to test the hypothesis that beta-blockers are safe in this setting. | 2010 | 20498415 |
| population genomic sequencing of coccidioides fungi reveals recent hybridization and transposon control. | we have sequenced the genomes of 18 isolates of the closely related human pathogenic fungi coccidioides immitis and coccidioides posadasii to more clearly elucidate population genomic structure, bringing the total number of sequenced genomes for each species to 10. our data confirm earlier microsatellite-based findings that these species are genetically differentiated, but our population genomics approach reveals that hybridization and genetic introgression have recently occurred between the two ... | 2010 | 20516208 |
| institutional open access funds: now is the time. | to date, the berkeley oa fund has ensured that 43 articles are free to be read immediately upon publication and 44 additional articles are now in the pipeline. the full scope of oa publishing during this period was significantly larger, at least by a factor of four. the oa fund allocation will continue to be carefully managed over the coming years. we are tracking our potential liability assuming the oa landscape grows with additional publishers and oa options. the amount predicted as necessary ... | 2010 | 20520845 |
| the analgesic and antihyperalgesic effects of transcranial electrostimulation with combined direct and alternating current in healthy volunteers. | transcranial electrostimulation (tes) has been reported to produce clinically significant analgesia, but randomized and double-blind studies are lacking. we investigated the analgesic and antihyperalgesic effects of tes in validated human experimental pain models. | 2010 | 20530614 |
| a spatially-explicit model of acarological risk of exposure to borrelia burgdorferi-infected ixodes pacificus nymphs in northwestern california based on woodland type, temperature, and water vapor. | in the far-western united states, the nymphal stage of the western black-legged tick, ixodes pacificus, has been implicated as the primary vector to humans of borrelia burgdorferi sensu stricto (hereinafter referred to as b. burgdorferi), the causative agent of lyme borreliosis in north america. in the present study, we sought to determine if infection prevalence with b. burgdorferi in i. pacificus nymphs and the density of infected nymphs differ between dense-woodland types within mendocino cou ... | 2010 | 20532183 |
| do california counties with lower socioeconomic levels have less access to emergency department care? | the study objective was to examine the relationship between number of emergency departments (eds) per capita in california counties and measures of socioeconomic status, to determine whether individuals living in areas with lower socioeconomic levels have decreased access to emergency care. | 2010 | 20536805 |
| polybrominated diphenyl ether (pbde) levels in peregrine falcon (falco peregrinus) eggs from california correlate with diet and human population density. | peregrine falcons are now considered a conservation success story due in part to the phasing out of harmful contaminants that adversely affected reproduction. recent studies have shown that peregrine eggs collected from california cities, however, have high levels of the higher-brominated polybrominated diphenyl ethers (sigmapbde(183-209)), a class of industrial flame retardants, in comparison to published data for other wildlife. sources of these high pbde levels and unusual pbde profiles are u ... | 2010 | 20540532 |
| pbdes in 2-5 year-old children from california and associations with diet and indoor environment. | this study determined the body burden of pbdes in 100 california children, and evaluated associations with sociodemographic, household, and dietary factors. in national and international comparisons, california dust, breast milk, and human serum samples contain higher concentrations of pbdes. higher levels in children suggest exposure pathways depend upon age. plasma samples were analyzed for pbdes using gc/ms. circulating levels of pbdes were 10-to 1000-fold higher than similar aged populations ... | 2010 | 20196589 |
| comparative effectiveness of two pharmacy-based colorectal cancer screening interventions during an annual influenza vaccination campaign. | to compare the effectiveness of two different pharmacy-based colorectal cancer screening (crcs) interventions taking place during an annual influenza vaccination campaign. | 2010 | 20199960 |
| economic cost analysis of west nile virus outbreak, sacramento county, california, usa, 2005. | in 2005, an outbreak of west nile virus (wnv) disease occurred in sacramento county, california; 163 human cases were reported. in response to wnv surveillance indicating increased wnv activity, the sacramento-yolo mosquito and vector control district conducted an emergency aerial spray. we determined the economic impact of the outbreak, including the vector control event and the medical cost to treat wnv disease. wnv disease in sacramento county cost approximately $2.28 million for medical trea ... | 2010 | 20202424 |
| surveillance lessons from first-wave pandemic (h1n1) 2009, northern california, usa. | after the appearance of pandemic (h1n1) 2009 in april 2009, influenza activity was monitored within the kaiser permanente northern california division by using laboratory, pharmacy, telephone calls, and utilization (services patients received) data. a combination of testing and utilization data showed a pattern of disease activity, but this pattern may have been affected by public perception of the epidemic. | 2010 | 20202431 |
| lessons from practice: risk of cin 3 or cancer associated with an lsil or hpv-positive asc-us screening result in women aged 21 to 24. | to characterize the risks of cervical intraepithelial neoplasia 3 (cin 3) and cancer in women aged 21 to 24 with human papillomavirus (hpv)-positive atypical squamous cells of undetermined significance (asc-us) and low-grade squamous intraepithelial lesion (lsil) screening results in routine clinical practice. | 2010 | 20354416 |
| chimpanzee research today. cutting to the bone of human origins. | 2010 | 20360089 | |
| tracing the origins of mycobacterium bovis tuberculosis in humans in the usa to cattle in mexico using spoligotyping. | to compare genotypes of mycobacterium bovis strains from humans in southern california with genotypes of m. bovis strains in cattle in mexico and the usa to explore the possible origins of human infections. | 2010 | 20399697 |
| evaluation of efficacy and human health risk of aerial ultra-low volume applications of pyrethrins and piperonyl butoxide for adult mosquito management in response to west nile virus activity in sacramento county, california. | the sacramento and yolo mosquito and vector control district (symvcd, also referred to as "the district") conducts surveillance and management of mosquitoes in sacramento and yolo counties in california. following an increase in numbers and west nile virus (wnv) infection rates of culex tarsalis and culex pipiens, the district decided on july 26, 2007, to conduct aerial applications of evergreen ec 60-6 (60% pyrethrins: 6% piperonyl butoxide) over approximately 215 km2 in the north area of sacra ... | 2010 | 20402352 |
| non-prescription syringe sales in california: a qualitative examination of practices among 12 local health jurisdictions. | legislation permitting non-prescription syringe sales (npss) was passed in 2004 in california as a structural intervention designed to expand access to syringes for injection drug users. as of december 2009, 19 of california's 61 local health jurisdictions (lhjs) have approved policies to authorize pharmacies to sell non-prescription syringes. the legislation faces termination in 2010 if current evaluation efforts fail to demonstrate outcomes defined in the legislation. using qualitative methods ... | 2010 | 20405227 |
| spread of adenovirus to geographically dispersed military installations, may-october 2007. | in mid-may 2007, a respiratory disease outbreak associated with adenovirus, serotype b14 (ad14), was recognized at a large military basic training facility in texas. the affected population was highly mobile; after the 6-week basic training course, trainees immediately dispersed to advanced training sites worldwide. accordingly, enhanced surveillance and control efforts were instituted at sites receiving the most trainees. specimens from patients with pneumonia or febrile respiratory illness wer ... | 2010 | 20409365 |
| seasonal synchronization of influenza in the united states older adult population. | in temperate regions, influenza epidemics occur annually with the highest activity occurring during the winter months. while seasonal dynamics of the influenza virus, such as time of onset and circulating strains, are well documented by the centers for disease control and prevention influenza surveillance system, an accurate prediction of timing, magnitude, and composition of circulating strains of seasonal influenza remains elusive. to facilitate public health preparedness for seasonal influenz ... | 2010 | 20419169 |
| communicating marine reserve science to diverse audiences. | as human impacts cause ecosystem-wide changes in the oceans, the need to protect and restore marine resources has led to increasing calls for and establishment of marine reserves. scientific information about marine reserves has multiplied over the last decade, providing useful knowledge about this tool for resource users, managers, policy makers, and the general public. this information must be conveyed to nonscientists in a nontechnical, credible, and neutral format, but most scientists are no ... | 2010 | 20427745 |
| patenting of human genetic material v. bioethics: revisiting the case of john moore v. regents of the university of california. | moore v. regents of the university of california was one of the first cases internationally that dealt with the patenting of human genetic material. the case is closely related to the development of medicine and of biotechnology applied to medicine. these developments require the utilisation of human body parts, both for experiments and for transplant, and present certain major medico-legal problems. however, the case did not produce conclusive decisions on the various key legal issues that it r ... | 2010 | 20432879 |
| black and organic carbon emission inventories: review and application to california. | particulate black or elemental carbon (ec) (black carbon [bc]) and organic carbon (oc) affect climate, visibility, and human health. several "top-down" and "bottom-up" global emission inventories for these components have compiled country-wide emission factors, source profiles, and activity levels that do not necessarily reflect local conditions. recent estimates of global bc and oc emissions range from 8 to 24 and 33 to 62 tg (1012 g) per year, respectively. u.s. bc emissions account for 5.6% o ... | 2010 | 20437785 |
| tickborne powassan virus infections among wisconsin residents. | powassan virus (powv) is a tickborne flavivirus that causes a rare but potentially life-threatening illness. the first reported case of powv infection in a wisconsin resident occurred in 2003. enhanced surveillance and testing detected 2 additional cases. | 2010 | 20443328 |
| treatment preferences: impact of risk and benefit in decision-making. | understanding treatment preferences of seriously ill patients is complex. previous studies have shown a correlation between the burden and outcome of a treatment and the likelihood a patient will accept a given intervention. in this study the willingness to accept life sustaining treatment (walt) survey was used in a predominantly latino population receiving care at a large urban safety net hospital. eligible patients were cared for by one of four clinics: (1) human immunodeficiency virus (hiv); ... | 2010 | 20050792 |
| using geographic information systems (gis) to assess outcome disparities in patients with type 2 diabetes and hyperlipidemia. | geographic information systems (gis) tools can help expand our understanding of disparities in health outcomes within a community. the purpose of this project was (1) to demonstrate the methods to link a disease management registry with a gis mapping and analysis program, (2) to address the challenges that occur when performing this link, and (3) to analyze the outcome disparities resulting from this assessment tool in a population of patients with type 2 diabetes mellitus. | 2010 | 20051547 |
| discretionary calorie intake a priority for obesity prevention: results of rapid participatory approaches in low-income us communities. | since resources are limited, selecting the most promising targets for obesity interventions is critical. we examined the relative associations of physical activity, fruit and vegetable consumption and 'junk food' consumption with bmi and the prevalence of relevant policies in school, work, food outlets and health-care settings. | 2010 | 20056777 |
| multistate outbreak of human salmonella typhimurium infections associated with aquatic frogs - united states, 2009. | during april-july 2009, the utah department of health identified five cases of salmonella typhimurium infection with indistinguishable pulsed-field gel electrophoresis (pfge) patterns, predominantly among children. in august, cdc began a multistate outbreak investigation to determine the source of the infections. this report summarizes the results of this ongoing investigation, which, as of december 30, had identified 85 s. typhimurium human isolates with the outbreak strain from 31 states. in a ... | 2010 | 20057349 |
| quality of life, characteristics and survival of patients with hiv and lymphoma. | we sought to compare the quality of life (qol), characteristics, and survival of patients with non-hodgkin lymphoma (nhl) with and without human immunodeficiency virus (hiv) infection. | 2010 | 20058087 |
| influenza a viruses in wild birds of the pacific flyway, 2005-2008. | avian influenza viruses (aivs) pose a significant threat to public health, and viral subtypes circulating in natural avian reservoirs can contribute to the emergence of pathogenic influenza viruses in humans. we investigated the prevalence and distribution of aivs in 8826 migratory and resident wild birds in north america along the pacific flyway, which is a major north-south migration pathway that overlaps with four other flyways in alaska providing opportunities for mixing of eurasian and amer ... | 2010 | 20059316 |
| evidence of bias in studies of influenza vaccine effectiveness in elderly patients. | although studies have shown influenza vaccines to be effective in preventing death in the elderly population, these findings may be the result of selection bias. we examined the relationship between vaccination, age, underlying morbidity, and probability of death in the upcoming year. vaccination coverage varied in a curvilinear fashion with age, morbidity, and risk of death. forgoing vaccination predicted death in those who had received vaccinations in the previous 5 years, but it predicted sur ... | 2010 | 19995265 |
| correlation of genotype and in vitro susceptibilities of cryptococcus gattii strains from the pacific northwest of the united states. | cryptococcus gattii emerged in north america in 1999 as a human and veterinary pathogen on vancouver island, british columbia. the emergent subtype, vgiia, and the closely related subtype vgiib can now be found in the united states in washington, oregon, and california. we performed multilocus sequence typing and antifungal susceptibility testing on 43 isolates of c. gattii from human patients in oregon, washington, california, and idaho. in contrast to vancouver island, vgiia was the most frequ ... | 2010 | 20007380 |
| microbiological water quality at non-human influenced reference beaches in southern california during wet weather. | although urban wet weather discharges may have elevated concentrations of fecal indicator bacteria impacting water quality at swimming beaches, not all of these bacteria may arise from human sources. in this study, the contribution of non-human fecal indicator bacteria was quantified by sampling coastal reference beaches in southern california. samples were collected at beaches near stormwater discharges from undeveloped watersheds and analyzed for total coliform, escherichia coli, and enterococ ... | 2010 | 20015517 |
| triglyceride-rich lipoproteins and plasma lipid transport. | this memoir provides a history of the triglyceride-rich lipoproteins of blood plasma over the last half-century. as precursors of low-density lipoproteins and in their own right, triglyceride-rich lipoproteins are essential to the formation of atherosclerotic plaques and to consequent ischemic vascular disease. the author recounts research at the national heart institute during 1953 to 1956 and continuing thereafter at the university of california san francisco. emphasis is placed on key insight ... | 2010 | 20018941 |
| seroprevalence of trypanosoma cruzi among eleven potential reservoir species from six states across the southern united states. | trypanosoma cruzi, the causative agent of chagas' disease, is a substantial public health concern in latin america. although rare in humans and domestic animals in the united states, t. cruzi is commonly detected in some wildlife species, most commonly raccoons (procyon lotor) and virginia opossums (didelphis virginiana). to increase our understanding of the reservoir host species range and geographic distribution, 11 species of mammals from six states spanning the known range of t. cruzi (arizo ... | 2010 | 20020815 |
| phenotypic characteristics of novel swine-origin influenza a/california/07/2009 (h1n1) virus. | the 2009 novel a(h1n1) virus appears to be of swine origin. this strain causing the current outbreaks is a new virus that has not been seen previously either in humans or animals. we have previously reported that viruses causing pandemics or large outbreaks were able to grow at a temperature above the normal physiological range (temperature resistance, non-ts phenotype), were found to be inhibitor resistant and restricted in replication at suboptimal temperature (sensitivity to grow at low tempe ... | 2010 | 20021501 |
| ecological control of fecal indicator bacteria in an urban stream. | fecal indicator bacteria (fib) have long been used as a marker of fecal pollution in surface waters subject to point source and non-point source discharges of treated or untreated human waste. in this paper, we set out to determine the source(s) of elevated fib concentrations in cucamonga creek, a concrete-lined urban stream in southern california. flow in the creek consists primarily of treated and disinfected wastewater effluent, mixed with relatively smaller but variable flow of runoff from t ... | 2010 | 20028091 |
| severe 2009 h1n1 influenza in pregnant and postpartum women in california. | like previous epidemic and pandemic diseases, 2009 pandemic influenza a (h1n1) may pose an increased risk of severe illness in pregnant women. | 2010 | 20032319 |
| rickettsia 364d: a newly recognized cause of eschar-associated illness in california. | four spotted fever group rickettsiae (sfgr) are known to infect humans in the united states. a member of the sfgr designated 364d and detected in dermacentor occidentalis ticks has not previously been identified as a human pathogen. | 2010 | 20073993 |
| the california stem cell initiative: persuasion, politics, and public science. | the california institute for regenerative medicine (cirm) was created by a california ballot initiative to make stem cell research a constitutional right, in response to bush administration restrictions on stem cell research. the initiative created a taxpayer-funded, multibillion-dollar institution, intended to advance public health by developing cures and treatments for diabetes, cancer, paralysis, and other conditions. the initiative has been highly controversial among stakeholders and watchdo ... | 2010 | 20075315 |
| enhancing spatial detection accuracy for syndromic surveillance with street level incidence data. | the department of defense military health system operates a syndromic surveillance system that monitors medical records at more than 450 non-combat military treatment facilities (mtf) worldwide. the electronic surveillance system for early notification of community-based epidemics (essence) uses both temporal and spatial algorithms to detect disease outbreaks. this study focuses on spatial detection and attempts to improve the effectiveness of the essence implementation of the spatial scan stati ... | 2010 | 20082711 |
| coinfection of western gray squirrel (sciurus griseus) and other sciurid rodents with borrelia burgdorferi sensu stricto and anaplasma phagocytophilum in california. | overlapping geographic distributions of tick-borne disease agents utilizing the same tick vectors are common, and coinfection of humans, domestic animals, wildlife, and ticks with both borrelia burgdorferi and anaplasma phagocytophilum has been frequently reported. this study was undertaken in order to evaluate the prevalence of both b. burgdorferi sensu stricto (hereinafter referred to as b. burgdorferi) and a. phagocytophilum in several species of sciurid rodents from northern california, usa. ... | 2010 | 20090047 |
| burden of influenza-related hospitalizations among children with sickle cell disease. | children with sickle cell disease (scd) are considered to be at high risk for complications from influenza infection despite minimal published data that characterize the burden of influenza in this population. our objectives were to (1) estimate the rate of influenza-related hospitalizations (irhs) among children with scd, (2) compare this rate with rates of children with cystic fibrosis (cf) and children with neither scd nor cf, and (3) explore mechanisms that underlie these potentially prevent ... | 2010 | 20100764 |
| pbde concentrations in women's serum and fecundability. | exposure to polybrominated diphenyl ether (pbde) flame retardants is widespread, with 97% of americans having detectable levels. although pbdes have been associated with reproductive and hormonal effects in animals, no human studies have examined their association with fertility. | 2010 | 20103495 |
| shifting away from silos. the interoperability challenges that hospitals face pale in comparison to the headaches plaguing state departments. | 2010 | 20120892 | |
| participation in the decision to become vaccinated against human papillomavirus by california high school girls and the predictors of vaccine status. | state and national policymakers are actively debating the merits of legally mandating the human papillomavirus (hpv) vaccine. | 2010 | 20122474 |
| international cohort analysis of the antiviral activities of zidovudine and tenofovir in the presence of the k65r mutation in reverse transcriptase. | a k65r mutation in hiv-1 reverse transcriptase can occur with the failure of tenofovir-, didanosine-, abacavir-, and, in some cases, stavudine-containing regimens and leads to reduced phenotypic susceptibility to these drugs and hypersusceptibility to zidovudine, but its clinical impact is poorly described. we identified isolates with the k65r mutation within the stanford resistance database and a french cohort for which subsequent treatment and virological response data were available. the part ... | 2010 | 20124005 |
| primary signet-ring carcinoma (src) of the lung: a population-based epidemiologic study of 262 cases with comparison to adenocarcinoma of the lung. | the presence of signet-ring cell component has been described as a prominent feature of eml4-alk positive non-small cell lung cancer. we investigated the clinicopathologic features and survival outcome of primary signet-ring carcinoma (src) of the lung with comparison to adenocarcinoma of the lung. | 2010 | 20130484 |
| compounded effects of climate change and habitat alteration shift patterns of butterfly diversity. | climate change and habitat destruction have been linked to global declines in vertebrate biodiversity, including mammals, amphibians, birds, and fishes. however, invertebrates make up the vast majority of global species richness, and the combined effects of climate change and land use on invertebrates remain poorly understood. here we present 35 years of data on 159 species of butterflies from 10 sites along an elevational gradient spanning 0-2,775 m in a biodiversity hotspot, the sierra nevada ... | 2010 | 20133854 |
| planning a study abroad clinical experience. | not only is globalization expanding areas of human activity, it is also influencing the variety of educational offerings in universities. therefore, globalization must be considered by nurse educators as they reevaluate ways of preparing nursing students to meet the health care needs of populations they currently serve and will care for in the future. study abroad programs have been encouraged to be part of the college experience in the united states for more than 30 years; however, these progra ... | 2010 | 20143756 |
| fulminant myocarditis associated with pandemic h1n1 influenza a virus in children. | 2010 | 20153131 | |
| partitioning phase preference for secondary organic aerosol in an urban atmosphere. | secondary organic aerosol (soa) comprises a significant portion of atmospheric particular matter. the impact of particular matter on both human health and global climate has long been recognized. despite its importance, there are still many unanswered questions regarding the formation and evolution of soa in the atmosphere. this study uses a modeling approach to understand the preferred partitioning behavior of soa species into aqueous or organic condensed phases. more specifically, this work us ... | 2010 | 20176970 |
| enteric bacterial pathogen detection in southern sea otters (enhydra lutris nereis) is associated with coastal urbanization and freshwater runoff. | although protected for nearly a century, california's sea otters have been slow to recover, in part due to exposure to fecally-associated protozoal pathogens like toxoplasma gondii and sarcocystis neurona. however, potential impacts from exposure to fecal bacteria have not been systematically explored. using selective media, we examined feces from live and dead sea otters from california for specific enteric bacterial pathogens (campylobacter, salmonella, clostridium perfringens, c. difficile an ... | 2010 | 19720009 |
| human health risk assessment of endosulfan. part iv: occupational reentry and public non-dietary exposure and risk. | the california department of pesticide regulation (cdpr) and the united states environmental protection agency (usepa) released revised draft risk assessments for the pesticidal active ingredient, endosulfan, just 2months apart, in november 2007 and january 2008. the exposure estimates, critical to risk assessment, were calculated by each agency using dissimilar approaches in certain aspects. the scenarios for which exposures and risks were estimated also varied somewhat between the two agencies ... | 2010 | 19733201 |
| human health risk assessment of endosulfan: ii. dietary exposure assessment. | the california department of pesticide regulation (cdpr) and the united states environmental protection agency (usepa) performed dietary exposure assessments for endosulfan in 1998 and 2002, respectively. results of the usepa assessment showed an increased risk for the population sub-group "children 1-6 years" (>100% of the population adjusted dose [pad]). usepa then required registrants to satisfy database uncertainties by performing subchronic neurotoxicity and developmental neurotoxicity stud ... | 2010 | 19733202 |
| human health risk assessment of endosulfan. i: toxicology and hazard identification. | endosulfan is persistent in the environment and toxic to wildlife. legal mandates necessitate that a risk assessments be performed for endosulfan by the california department of pesticide regulation (cdpr) and the united states environmental protection agency (usepa). this hazard identification (hazard id) compared critical no-observed effect levels (noel) for acute, subchronic and chronic exposure intervals between the agencies. noels were discussed in light of their application to numerous exp ... | 2010 | 19733203 |
| assessing marine debris in deep seafloor habitats off california. | marine debris is a global concern that pollutes the world's oceans, including deep benthic habitats where little is known about the extent of the problem. we provide the first quantitative assessment of debris on the seafloor (20-365 m depth) in submarine canyons and the continental shelf off california, using the delta submersible. fishing activities were the most common contributors of debris. highest densities occurred close to ports off central california and increased significantly over the ... | 2010 | 19751942 |
| gain-of-function variant in glud2 glutamate dehydrogenase modifies parkinson's disease onset. | parkinson's disease (pd), a common neurodegenerative disorder characterized by progressive loss of dopaminergic neurons and their terminations in the basal ganglia, is thought to be related to genetic and environmental factors. although the pathophysiology of pd neurodegeneration remains unclear, protein misfolding, mitochondrial abnormalities, glutamate dysfunction and/or oxidative stress have been implicated. in this study, we report that a rare t1492g variant in glud2, an x-linked gene encodi ... | 2010 | 19826450 |
| tumor marker phenotype concordance in second primary breast cancer, california, 1999-2004. | breast cancer is the most common cancer among women. it is estimated that 7% of women who have breast cancer will develop a subsequent second independent breast tumor within 10 years of the first. the status of estrogen (er), progesterone (pr) and human growth hormone (her2) receptors, individually and as phenotypic combinations, impacts the clinical course of breast cancer and may impact the course of subsequent primary tumors and patient survival. our aims were to determine tumor marker phenot ... | 2010 | 19629680 |
| human health risk assessment of endosulfan. part iii: occupational handler exposure and risk. | the united states environmental protection agency (usepa) and the california department of pesticide regulation (cdpr) have authority to regulate pesticides, respectively, within the united states and within the state of california. both agencies are obligated to protect human and environmental health within the geographical boundaries where they have authority. risk assessment of pesticidal active ingredients is conducted by both usepa and cdpr, yet the agencies have different legal mandates th ... | 2010 | 19854234 |
| residential air exchange rates in three major us metropolitan areas: results from the relationship among indoor, outdoor, and personal air study 1999-2001. | we report approximately 500 indoor-outdoor air exchange rate (aer) calculations based on measurements conducted in residences in three us metropolitan areas in 1999-2001: elizabeth, new jersey; houston, texas; and los angeles county, california. overall, a median aer across these urban areas and seasons was 0.71 air changes per hour (ach, or per hour; n = 509) while median aers measured in california (n = 182), new jersey (n = 163), and texas (n = 164) were 0.87, 0.88, and 0.47 ach, respectively ... | 2010 | 19874401 |
| paraoxonase 1, agricultural organophosphate exposure, and parkinson disease. | human, animal and cell models support a role for pesticides in the etiology of parkinson disease. susceptibility to pesticides may be modified by genetic variants of xenobiotic enzymes, such as paraoxonase, that play a role in metabolizing some organophosphates. | 2010 | 19907334 |
| geographic genetic differentiation of a malaria parasite, plasmodium mexicanum, and its lizard host, sceloporus occidentalis. | gene flow, and resulting degree of genetic differentiation among populations, will shape geographic genetic patterns and possibly local adaptation of parasites and their hosts. some studies of plasmodium falciparum in humans show substantial differentiation of the parasite in locations separated by only a few kilometers, a paradoxical finding for a parasite in a large, mobile host. we examined genetic differentiation of the malaria parasite plasmodium mexicanum, and its lizard host, sceloporus o ... | 2010 | 19916631 |
| human embryonic stem cell research and proposition 71. reflections on californiaôçös response to federal policy. | in response to former president george w. bush's funding limitations on human embryonic stem cell (hesc) research, california voters in 2004 passed proposition 71, the most expansive state-funded medical research initiative in united states history. this study examines california's experiment in the life sciences, a particularly fitting analysis now as president barack obama has freed up additional federal funding for hesc research. in addition to exploring the general pitfalls of states, rather ... | 2010 | 21761982 |
| differences in prevalence of borrelia burgdorferi and anaplasma spp. infection among host-seeking dermacentor occidentalis, ixodes pacificus, and ornithodoros coriaceus ticks in northwestern california. | previous studies revealed that the pacific coast tick (dermacentor occidentalis) is infected occasionally with the agents of lyme disease (borrelia burgdorferi) or human granulocytic anaplasmosis (anaplasma phagocytophilum) and that it is an inefficient experimental vector of b. burgdorferi. the relationship of the pajahuello tick (ornithodoros coriaceus) to each of these bacterial zoonotic agents has not been reported. the primary bridging vector of both bacterial zoonotic agents to humans is t ... | 2010 | 21359090 |
| respiratory syncytial virus testing during bronchiolitis episodes of care in an integrated health care delivery system: a retrospective cohort study. | bronchiolitis has the highest incidence rate of any lower respiratory infection among infants and children <2 years of age. respiratory syncytial virus (rsv) is the most common etiology of bronchiolitis. the american academy of pediatrics does not recommend routine rsv testing for infants and children with bronchiolitis. the clinical predictors of rsv testing are unknown. objectives: the aims of this study were to identify the rates and predictors of rsv testing during bronchiolitis and to explo ... | 2010 | 21316538 |
| spatial patterns of fishing effort off san diego: implications for zonal management and ecosystem function. | the essence of ecosystem-based management is managing human practices to conserve the ecosystem. ecologists focus on understanding the ecosystem, but there are fundamental information gaps including patterns of human exploitation. in particular, the spatial distribution of fishing effort must be known at the scales needed for ecologically relevant management. fishing is a primary impact on coastal ecosystems, yet catch distribution at scales relevant to habitats and processes are not well known ... | 2010 | 21265452 |
| comparison of anthropometry of u.s. electric utility field-workers with north american general populations. | the primary purpose of this study was to determine whether conventional anthropometric databases of the u.s. general population are applicable to the population of u.s. electric utility field-workers. | 2010 | 21284367 |
| evidence for thyroid endocrine disruption in wild fish in san francisco bay, california, usa. relationships to contaminant exposures. | it is well documented that many coastal and estuarine environments adjacent to developed and industrialized urban centers, such as the san francisco bay area, are significantly contaminated by anthropogenic chemicals. however, it is not well understood to what extent existing contaminants, many with continuing inflows into the environment, may impact exposed wildlife. this study provided an initial characterization of thyroid endocrine-related effects and their relationship to accumulated contam ... | 2010 | 19939474 |
| risk factors of herpes zoster among children immunized with varicella vaccine: results from a nested case-control study. | previous studies of varicella-zoster virus reactivation in children have provided little information on potential risk factors. the aim of this study was to investigate the effects of race, chronic medical conditions and treatments, and recent vaccination, on the risk of herpes zoster (hz) in children vaccinated with one dose of varicella vaccine. | 2010 | 19952977 |
| foramen magnum ontogeny in homo sapiens: a functional matrix perspective. | historically, the foramen magnum (fm) has been an integral component of studies on skull ontogeny and evolutionary transformations of cranial form. although this foramen has been considered a single entity, we hypothesize that it comprises two functional matrices, a ventral matrix and a dorsal matrix. in general, the ventral matrix is related to locomotor functions, whereas the dorsal matrix is related to neurological functions and fluid flow dynamics. to test our hypothesis, we used a large ont ... | 2010 | 21234994 |
| incorporation of spatial and economic analyses of human-use data in the design of marine protected areas. | social, economic, and ecological criteria contribute to the successful design, implementation, and management of marine protected areas (mpas). in the context of california's marine life protection act initiative, we developed a set of methods for collecting, compiling, and analyzing data about the spatial extent and relative economic importance of commercial and recreational fishing. we interviewed 174 commercial fishers who represented the major fisheries in the initiative's north-central coas ... | 2010 | 21175829 |
| genetic diversity of borrelia burgdorferi and detection of b. bissettii-like dna in serum of north-coastal california residents. | in north america, lyme borreliosis (lb) is a tick-borne disease caused by infection with the spirochete borrelia burgdorferi. we studied the genetic diversity of lb spirochetes in north-coastal california residents. spirochete dna was detected in 23.7% (27/114) of the study subjects using a pcr protocol optimized for increased sensitivity in human sera. californians were most commonly infected with b. burgdorferi ospc genotype a, a globally widespread spirochete associated with high virulence in ... | 2010 | 21177909 |
| employment. plan abused its discretion by denying man disability benefits. | 2010 | 21188743 | |
| serious psychological distress and diabetes care among california adults. | to evaluate three aspects of diabetes care (foot checks, eye examinations, and hemoglobin a 1 c checks by a physician) among california adults with type 2 diabetes and serious psychological distress (spd). | 2010 | 21166335 |
| safety and immunogenicity of a trivalent single dose seasonal influenza vaccine containing pandemic a(h1n1) antigen in younger and elderly subjects: a phase iii open-label single-arm study. | during the pandemic of the 2009 a(h1n1) influenza virus strain, 20-40% of the population in some areas were infected. infection with a(h1n1) may be mild, with an average case fatality rate below 0.25%, but severe disease is not limited to patients with underlying medical conditions. since a(h1n1) is expected to continue to circulate it is included in the seasonal influenza vaccines for the 2010-2011 winter season. we investigated the immunogenicity and safety of a preservative-free non-adjuvante ... | 2010 | 21167116 |
| weighing the evidence for newborn screening for hemoglobin h disease. | to conduct a systematic review to assist the united states secretary of health and human services advisory committee on heritable disorders in newborns and children (sachdnc) to determine whether hemoglobin h screening should be included among the core recommended conditions for newborn screening. | 2010 | 21167500 |
| impact of urbanization and agriculture on the occurrence of bacterial pathogens and stx genes in coastal waterbodies of central california. | fecal pollution enters coastal waters through multiple routes, many of which originate from land-based activities. runoff from pervious and impervious land surfaces transports pollutants from land to sea and can cause impairment of coastal ocean waters. to understand how land use practices and water characteristics influence concentrations of fecal indicator bacteria (fib) and pathogens in natural waters, fourteen coastal streams, rivers, and tidal lagoons, surrounded by variable land use and an ... | 2010 | 21168181 |
| acute illnesses associated with exposure to fipronil--surveillance data from 11 states in the united states, 2001-2007. | fipronil is a broad-spectrum phenylpyrazole insecticide widely used to control residential pests and is also commonly used for flea and tick treatment on pets. it is a relatively new insecticide and few human toxicity data exist on fipronil. | 2010 | 20849331 |
| initial identification and characterization of an emerging zoonotic influenza virus prior to pandemic spread. | two cases of febrile respiratory illness associated with untypeable influenza a virus were identified in southern california in march 2009. one was initially detected as influenza virus using an experimental diagnostic device in a clinical trial, while the other was detected at a local reference lab using a diagnostic pcr assay. in both cases, analyses yielded negative results for strain-specific tests targeting circulating strains of influenza a virus (seasonal h1 and h3). these two samples bec ... | 2010 | 20861338 |
| continuous subcutaneous instillation of bupivacaine compared to saline reduces interleukin 10 and increases substance p in surgical wounds after cesarean delivery. | recent evidence suggests that locally delivered local anesthetics may exert tissue-damaging effects such as chondrolysis after intraarticular injection. alteration of the inflammatory response is a potential mechanism for local anesthetic-induced tissue toxicity. in this study, we tested the effects of continuous local anesthetic infiltration on the release of inflammatory and nociceptive mediators in skin wounds after cesarean delivery. | 2010 | 20861424 |
| a rapid, strong, and convergent genetic response to urban habitat fragmentation in four divergent and widespread vertebrates. | urbanization is a major cause of habitat fragmentation worldwide. ecological and conservation theory predicts many potential impacts of habitat fragmentation on natural populations, including genetic impacts. habitat fragmentation by urbanization causes populations of animals and plants to be isolated in patches of suitable habitat that are surrounded by non-native vegetation or severely altered vegetation, asphalt, concrete, and human structures. this can lead to genetic divergence between patc ... | 2010 | 20862274 |