Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| [light and electron microscopic observations of sheep scrapie]. | two suffolk sheep diagnosed as scrapie clinically and epidemiologically were investigated light and electron microscopically. they were female and four years four months of age. spongiform lesions were found in the gray and white matter of midbrain, pons, medulla oblongata, spinal cord and the cerebellar white matter as well as the cerebral gray and white matter. ultrastructurally, the spongiform lesions were shown to be caused by vacuolation in neuronal perikarya, vacuolation and/or swelling of ... | 1986 | 3768187 |
| evidence that transmissible mink encephalopathy agent is biologically inactive in mice. | transmissible mink encephalopathy (tme) is probably a form of the sheep disease, scrapie, introduced by accidentally feeding mink with scrapie-infected sheep tissues. although no successful transmissions of tme to mice have been achieved previous work has involved various limitations. to maximize the possibility of transmission, 176 mice, representing 14 different genotypes mostly not previously tested with tme, were injected with tme-infected mink brain from three sources with different histori ... | 1986 | 2940470 |
| characterization of lipids in membrane vesicles from scrapie-infected hamster brain. | the lipid compositions of membrane vesicles from scrapie-infected and uninfected hamster brains were examined before and after detergent extraction. no differences were observed in polar lipids, glycolipids, gangliosides or neutral lipids examined by thin-layer chromatography. analysis of detergent-extracted cscl gradient fractions with high scrapie infectivity failed to reveal any glycerolphosphatides, although neutral lipids were demonstrated. the major neutral lipid associated with detergent- ... | 1985 | 3920350 |
| [prion antibodies and structure analysis clarify questions about atypical viruses. prion structure under the electron microscope]. | 1985 | 3920456 | |
| retinal degeneration in experimental scrapie after intraperitoneal or subcutaneous inoculation of hamsters. | hamsters injected intraperitoneally or subcutaneously with the scrapie agent developed photoreceptor degeneration. the degree of degeneration did not correlate well with infectivity titers of retinal tissue or stage of clinical encephalopathy, and was not as great as seen in intracerebrally injected animals. we conclude that retinal degeneration is universal in hamsters experimentally inoculated with the scrapie agent regardless of the route of inoculation. | 1985 | 3921398 |
| "slow infections"--a challenge to traditional concepts. | 1985 | 3934107 | |
| isonicotinic hydrazide causes seizures in scrapie-infected hamsters with shorter latency than in control animals: a possible gabaergic defect. | isonicotinic hydrazide, a drug that decreases the level of gaba, when injected subcutaneously in control and scrapie-infected hamsters induced tonic-clonic seizures in scrapie hamsters significantly earlier (p less than 0.0001) than in control animals. this suggests depression of the gabaergic system in scrapie-infected hamsters. to determine whether this lesion is pre or postsynaptic we measured the level of gaba, glutamate, cgmp and camp and the gaba-benzodiazepine receptor complex. | 1985 | 2857587 |
| specific proteins associated with creutzfeldt-jakob disease and scrapie share antigenic and carbohydrate determinants. | small amounts of brain tissue (2 g) infected with creutzfeldt-jakob disease (cjd) can be fractionated by using a simple 1-day method that includes lysis with n-lauroylsarcosine. unique fibrils have been identified previously in scrapie- and cjd-infected tissue. these fibrils were abundant in final fractions. preparations from human cjd autopsy material and from experimental hamster and guinea pig cjd all displayed readily identifiable fibrils that were not seen in control preparations. thus, the ... | 1985 | 2408277 |
| characterization of nucleic acids in membrane vesicles from scrapie-infected hamster brain. | this study reports the partial characterization of nucleic acids present in gradient fractions enriched for large membrane vesicles from scrapie-infected and uninfected hamster brains. labeling of phenol-extracted nucleic acids at the 3' or 5' ends revealed abundant amounts of low-molecular-weight rna and little or no dna. these nucleic acids survived nuclease treatment of membrane vesicles but were sensitive to rnase after phenol extraction. analysis of 5'-end-labeled nucleic acids by one- and ... | 1985 | 2409296 |
| sheep lymphocyte antigens and scrapie. | the frequencies of 15 lymphocyte antigens were determined in 2 experimental flocks of herdwick sheep derived from the same foundation stock. the blue flock had been bred for resistance, and the red flock for susceptibility, to a standard dose of the ssbp/1 source of scrapie injected subcutaneously. although there were marked frequently differences between the 158 red flock and 51 blue flock sheep tested these differences could be attributed to genetic drift. within the red flock no significant f ... | 1984 | 6470228 |
| [karyological characteristics of continuous mouse cell lines infected with the scrapie agent]. | a karyological study of murine cell line l, latently infected with different strains of the scrapie agent (compton and c-506) showed that the both variants number of chromosomes and the number of robertson's translocations of chromosomes decrease insignificantly with an increase in the time of subcultivation. the use of the c-method of differential chromosome staining revealed four new analogous chromosomes in both experimental cell lines. this phenomenon is probably specific for this infected c ... | 1984 | 6539520 |
| [epidemiology of aids]. | 1984 | 6730611 | |
| the reticuloendothelial system in scrapie pathogenesis. | a single injection of 1 mg dextran sulphate 500 per mouse considerably prolonged incubation times and produced survivors, even when given 3 days after intravenous or intraperitoneal scrapie infection. since this compound could be detected in mononuclear phagocytes of spleen and lymph nodes for up to 7 months, it is suggested that it impairs a particular step in the infectious process in these cells of the lymphoreticular system. blockage of the reticuloendothelial system by trypan blue and silic ... | 1984 | 6198455 |
| [the role of animals in central nervous system diseases in man]. | 1984 | 6400461 | |
| [the ola major histocompatibility complex of sheep. genetic frequencies compared in prélpe sheep with and without scrapie]. | the ola genic frequencies were studied in both normal "préalpe" sheep and those affected with scrapie. in the non-affected sheep of contaminated flocks, frequencies were generally decreased, compared with frequencies of the same factors in sick sheep or in non-infected controls. three ola-a genes significantly decreased; at this locus, results in "préalpe" and "ile-de-france" sheep were inversed. this observation excludes ola genes being involved in pathogeny or resistance to the disease, but su ... | 1984 | 6430472 |
| occurrence of ovine scrapie in japan: clinical and histological findings in mice inoculated with brain homogenates of an affected sheep. | 1984 | 6441054 | |
| ultrastructural morphology of amyloid fibrils from neuritic and amyloid plaques. | the structure of partially purified, cns amyloid fibrils from three different sources have been compared by negative stain em. the fibrils isolated from brains with senile dementia of alzheimer type were 4-8 nm in diameter, narrowing every 30-40 nm and apparently composed of two 2-4 nm filaments. the fibrils from a gerstmann-sträussler syndrome brain were 7-9 nm in diameter, narrowing every 70-80 nm and with a suggestion that they are composed of two 3-5 nm filaments. the fibrils isolated from 8 ... | 1983 | 6683919 |
| scrapie in france: some possible predisposing factors in the naturally-acquired disease of sheep. | a nationwide survey of the occurrence of scrapie in france during the 12-year period 1968-1979 has shown the disease to be more widespread than previously thought. the data suggest that certain sheep raising practices, such as transhumance (nomadic grazing), pen and pasture alternations, and use of animals for milk production, may play a possible role in disease prevalence. | 1983 | 6685940 |
| scrapie-associated fibrils in creutzfeldt-jakob disease. | scrapie of sheep, and creutzfeldt-jakob disease (cjd) of man belong to a group of transmissible encephalopathies which have been successfully transmitted to a variety of hosts. in susceptible hosts, these diseases are characterized by progressive degeneration of the central nervous system leading inevitably to death. the agents responsible for these diseases have not yet been identified, but they exhibit similar physicochemical characteristics. abnormal fibrils designated 'scrapie associated fib ... | 1983 | 6358899 |
| inability to transmit scrapie by transfection of mouse embryo cells in vitro. | infectivity of nucleic acid from highly infectious mouse scrapie brains was studied by transfecting the nucleic acid in vitro prior to inoculation into animals. foetal mouse brain and whole mouse embryo cultures were chosen as the cells used for the transfection. as an internal control, infectious nucleic acid was recovered from bacteriophage phi x174 and whole virus particles were obtained when cultures were transfected with herpes simplex virus dna. in contrast, none of the animals inoculated ... | 1982 | 6278059 |
| changes in the nigrostriatal system following microinjection of an unconventional agent. | the effect of apomorphine, a direct dopamine receptor agonist, was studied in golden hamsters after unilateral injection of scrapie agent (strain 263k) into the nigrostriatal system. twenty-five received an injection into the left striatum and 24 into the left substantia nigra. varying volumes (5, 1 and 0.5 microliterss) and dilutions of the homogenate (10(-2), 10(-3), 10(-4)) were used. the duration of the incubation period (delay of appearance of clinical signs of the disease) was dependent on ... | 1982 | 6807492 |
| experimental scrapie in golden syrian hamsters: temporal comparison of in vitro cell-fusing activity with brain infectivity and histopathological changes. | golden syrain hamsters were inoculated intracerebrally with the hamster-adapted 263k strain of scrapie virus, and the evolution of in vitro cell fusing activity induced by brain suspensions was compared with brain infectivity titers and histological changes. cell-fusing activity abruptly appeared 4 weeks after inoculation, 1 week before the earliest detectable histopathological changes, at an infectivity level of 7.6 log 50% lethal doses per g of brain. cell-fusing activity was sustained through ... | 1982 | 6809626 |
| optic nerve degeneration in hamsters experimentally infected with scrapie. | 1982 | 6890907 | |
| focal and asymmetrical vacuolar lesions in the brains of mice infected with certain strains of scrapie. | 1982 | 7180387 | |
| scrapie: strategies, stalemates, and successes. | 1982 | 6122977 | |
| immunological studies of scrapie infection. | 1982 | 6183292 | |
| retinal damage in scrapie mice. | retinal damages in mice infected with scrapie are reported. the effects ranged from no histopathological changes, through partial loss of the outer nuclear layer (onl) to the most severe changes with complete loss of onl cells and photoreceptors. for the most part, cells of inner nuclear and ganglion layers were spared. these changes were found in 23% of c57bl/6j mice injected with the me7 strain of scrapie and in 28.5% of vm mice injected with the 87 v strain, while no changes were found in 13 ... | 1982 | 7199805 |
| scrapie agent contains a hydrophobic protein. | the scrapie agent causes a degenerative nervous system disorder of sheep and goats. considerable evidence indicates that the scrapie agent contains a protein that is necessary for infectivity [prusiner, s. b., groth, d. f., cochran, s. p., masiarz, f. r., mckinley, m. p. & martinez, h. m. (1980) biochemistry 19, 4883-4891], but direct demonstration of a protein moiety has been hampered by lack of sufficiently purified preparations. employing preparations of the scrapie agent enriched 100- to 100 ... | 1981 | 6273882 |
| effect of vaccinia-activated macrophages on scrapie infection in hamsters. | 1981 | 7194567 | |
| perivascular infiltrates of leukocytes in brains of scrapie-infected mice. | 1981 | 7198185 | |
| ultrastructural cytochemical studies of cerebral microvasculature in scrapie infected mice. | alkaline phosphatase, 5'-nucleotidase nucleoside diphosphatase and thiamine pyrophosphatase activities were studied by cytochemical method applied to electron microscopy of brain microvasculature in normal and scrapie infected mice. in control mice, the major location of all phosphatases studied was the luminal plasma membrane of the endothelial cells. in scrapie infected mice, changes in activity and distribution of the above mentioned phosphatases manifested themselves in the appearance of the ... | 1981 | 6111887 |
| [hyperproduction of glial fibrillary acidic protein (gfa) during development of experimental scrapie in mice]. | 1981 | 6796203 | |
| [slow virus infections: the concept of chronic diseases]. | 1980 | 6999335 | |
| [experimental pathology of subacute spongiform encephalopathies]. | 1980 | 7011482 | |
| replication of the scrapie agent in ocular neural tissues. | optic nerves and retinas removed from hamsters experimentally inoculated with the scrapie agent contain a high titer of infectivity. ophthalmoscopic examination of these animals revealed gross lesions of retinopathy as early as 3 weeks before the onset of clinical signs of brain degeneration. these results suggest that the scrapie agent may spread centrifugally in nerve fibers after intracerebral inoculation and that the scrapie-associated retinopathy seen in hamsters is directly induced by the ... | 1980 | 6767244 |
| virologic and neurohistologic findings in dairy goats affected with natural scrapie. | virologic and neurohistologic findings in three dairy goats that became affected with scrapie while living with naturally infected suffolk sheep were essentially like those in affected sheep. virus, detected by mouse inoculation, was widespread in non-neural sites, particularly in lymphatic tissues and intestine. im most sites, titers of virus ranged from 3.0 to 3.5 log10 mouse intracerebral ld50/30 mg of tissue. virus was in nervous tissue in much higher titer. ranging from 5.1 to 5.8 log10, th ... | 1980 | 6767304 |
| sensitivity of scrapie infectivity to detergents and 2-mercaptoethanol. | exposure of fractions obtained from scrapie-infected mouse brain to triton x-100 resulted in no change in its infectivity except after sedimentation. infectivity was reduced after exposure to 2-mercaptoethanol but only in the presence of sds. these results support the view that protein is an important component of the scrapie agent and that disulfide bonds may play a part in maintaining the structural integrity of the infectious agent. | 1980 | 6768695 |
| host and viral genetic determinants of the behavioral effects of scrapie encephalopathy. | 1980 | 6773083 | |
| pathogenesis of mouse scrapie: evidence for neural spread of infection to the cns. | the replication of infectious agent has been studied in brain, thoracic cord, and lumbar cord of compton white mice (sinc87) infected with the 139a strain of scrapie. nine experiments were carried out using four different peripheral routes of injection. a highly consistent pattern of results was obtained in which replication in the cns started in the thoracic cord after about 35% of the total incubation period had elapsed (range 25 to 42%). this was followed by the simultaneous onset of replicat ... | 1980 | 6780656 |
| an epidemiologic critique of creutzfeldt-jakob disease. | 1980 | 6448751 | |
| antiviral compound effective against experimental scrapie. | 1979 | 89602 | |
| evidence for the low molecular weight nature of scrapie agent. | 1979 | 107457 | |
| slow viral infections. | 1979 | 231926 | |
| [naked deoxyribonucleic acid viroids as the causative agents of neuropathies?]. | 1979 | 431739 | |
| immunoglobulin g concentrations in the sera of herdwick sheep with natural scrapie. | 1979 | 528692 | |
| pathogenesis of mouse scrapie: effect of route of inoculation on infectivity titres and dose-response curves. | 1978 | 563870 | |
| scrapie scruples. | 1978 | 278924 | |
| sedimentation properties of the scrapie agent. | the sedimentation behavior of the scrapie agent in homogenates of spleen from infected mice has been determined. approximately 90% of the scrapie agent was sedimented at an omega2t value of 3 x 10(10) rad2/sec in a fixed-angle rotor. sedimentation of the agent was not substantially affected by sonication or by treatment with the detergent sodium deoxycholate. the sedimentation profiles of the scrapie agent were similar to those observed for free polyribosomes, but differed from those exhibited b ... | 1977 | 412193 |
| scrapie: a point of view. | 1977 | 275684 | |
| scrapie- the risks in perspective. | 1977 | 276740 | |
| genetic markers in herdwick sheep: no correlation with succeptibility or resistance to experimental scrapie. | genetic markers were studied in herdwick sheep, bred at compton, with special reference to genetically selected lines which differ in susceptibility or resistance to experimentally produced scrapie. there were no correlations between susceptibility to the disease and albumin, pre-albumin, esterase and haemoglobin phenotypes, and between reduced glutathione levels and alpha-mannosidase isoenzymes, the latter possibly representing a previously undescribed genetic marker in sheep. | 1977 | 606000 |
| virus-like particles from both control and scrapie-affected mouse brain. | 1977 | 559944 | |
| nucleic acids associated with detergent-treated synaptosomal plasma membranes from normal and scrapie-infected mouse brain. | 1976 | 828592 | |
| neurophysin in the brain and pituitary gland of normal and scrapie-affected sheep--i. its localization in the hypothalamus and neurohypophysis with particular reference to a new hypothalamic neurosecretory pathway to the median eminence. | by use of an immunofluorescence histochemical technique with a cross-species reactive antiserum to porcine neurophysin-ii the precise localization of neurophysin in the pituitary gland and the hypothalamic area of the brain of the sheep has been determined. neurophysin was confined to neurosecretory pathways originating from the supraoptic and paraventricular hypothalamic nuclei. the major pathway terminates in the neurohypophysis but in addition a second neurophysin-containing pathway proceeds ... | 1976 | 11370513 |
| [discovery of viroids and possible relationship with human and veterinary medicine]. | the researches of diener and co-workers and those of the semancik's group, have recently established that some plant diseases, such as potato spindle tuber, citrus exocortis disease and chrysanthemum stunt, are caused by a new class of pathogens, named viroids. these are the smallest known agents (they are smaller than viruses) having a molecular weight of ca 10(5) daltons, and composed of a highly structured rna, rich in guanine-cytosine base pairs without a capsid. little is known about the or ... | 1975 | 132907 |
| newer knowledge in comparative virology--its contribution to human health research. | like other comparative sciences, and despite its recent beginning comparative virology has already contributed useful applications and observations to human health research. teachings derived from the study of marek's disease found application in that of burkitt's lymphoma, and may lead to a possible vaccine against the human disease. equally useful information came from the study of canine distemper in the development of a chorio-allantoic membrane attenuated measles vaccine, and in our knowled ... | 1975 | 167504 |
| an electron microscopic study of the scrapie mouse and rat: further observations on virus-like particles with ruthenium red and lanthanum nitrate as a possible trace and negative stain. | 1974 | 4141754 | |
| scrapie and transmissible mink encephalopathy: search for infectious nucleic acid. | brain preparations from animals with scrapie or transmissible mink encephalopathy were phenol extracted and examined for the presence of pathogenic nucleic acid. animals inoculated with various extracts remained healthy, and analysis on 2.6 to 5% polyacrylamide gels failed to detect a difference in extractable rna species between infected and normal mink brain. | 1974 | 4207527 |
| maternal and lateral transmission of scrapie in sheep. | 1974 | 4212154 | |
| slow virus diseases of the central nervous system. | 1974 | 4213582 | |
| pathology of choroid plexus in spontaneous immune complex disease and chronic viral infections. | 1974 | 4276256 | |
| [visna virus-like particles in cultures of choroid plexus cells of a goat with symptoms of visna infection]. | 1974 | 4363195 | |
| further observations on the production of scrapie in sheep by oral dosing with foetal membranes from scrapie-affected sheep. | 1974 | 4425935 | |
| naturally-occurring scrapie in goats. | 1974 | 4859427 | |
| no mouse pmn leukocyte depression after inoculation with brain tissue from multiple sclerosis or spongiform encephalopathies. | 1974 | 4589575 | |
| a new hypothalamic pathway to the median eminence containing neurophysin and its hypertrophy in sheep with natural scrapie. | 1973 | 4571633 | |
| unsuccessful attempts to produce disease with tissues from mice fed on a diet containing cuprizone. | 1973 | 4736048 | |
| clinical and histological recovery from the scrapie-like spongiform encephalopathy produced in mice by feeding them with cuprizone. | 1973 | 4737068 | |
| replication of the factor in scrapie material that causes a decrease in polymorphonuclear neutrophils. | 1973 | 4737373 | |
| a cytological study of the karyotype of spleen cells from scrapie-affected chinese hamsters. | 1973 | 4738622 | |
| scrapie: a prototype slow infection. | 1972 | 4622954 | |
| changes in drinking and feeding habits of mice with experimental scrapie. | 1972 | 4630696 | |
| inoculation of voles, chinese hamsters, gerbils and guinea-pigs with scrapie brain material. | 1972 | 5065061 | |
| [new observations on the occurrence of a rna-dependent dna-polymerase]. | 1971 | 5102738 | |
| brain cell cultures from mice affected with scrapie or fed with cuprizone. | 1971 | 5107104 | |
| transmission and characterization of the agents of spongiform virus encephalopathies: kuru, creutzfeldt-jakob disease, scrapie and mink encephalopathy. | 1971 | 5000225 | |
| [human and animal neuropathology and the slow and latent viruses]. | 1971 | 5003725 | |
| viruses and autoimmune diseases in animals other than man. | 1971 | 4937605 | |
| scrapie in immunologically deficient mice. | 1971 | 4940428 | |
| chronic viral infections of the central nervous system. | 1971 | 4940819 | |
| altered plasma membranes in experimental scrapie. | 1971 | 4942441 | |
| histopathological similarities between scrapie and cuprizone toxicity in mice. | 1971 | 4101034 | |
| drinking behaviour in scrapie. | 1971 | 4101464 | |
| susceptibility of mink to sheep scrapie. | a progressive, fatal spongiform polioencephalopathy was induced in mink intracerebrally inoculated with a suspension of brain from a suffolk sheep with naturally acquired scrapie. the clinical signs and pathological lesions of the experimental disease were indistinguishable from transmissible mink encephalopathy, a disease of undetermined origin that occurs in mink. | 1971 | 4102123 |
| effects of antilymphocytic serum on host responses to infectious agents. | 1970 | 4312737 | |
| simple method of evaluating scrapie in mice. | mice in advanced scrapie characteristically clasp their hindlegs together. as the disease progresses into the clasping stage, mice exhibit a sequence of identifiable hindleg reactions which have categorized and assigned relative scores permitting objective, quantitative evaluation of disease. | 1970 | 5466135 |
| [isolation and identification of maedi--visna virus from a german sheep herd]. | 1970 | 4992952 | |
| inherited characteristics affecting neurotropic behaviour of scrapie. | 1969 | 5767040 | |
| neurological illness after inoculation of tissue from tumour bearing animals. | 1969 | 5813102 | |
| the fatty composition of brain and myelin of normal and scrapie-affected mice. | 1969 | 5813348 | |
| a comparison of some biological characteristics of the mouse-passaged scrapie agents, 22a and me7. | 1969 | 4978935 | |
| scrapie--eradication and field trial study of the natural disease. | 1969 | 5392186 | |
| invasion of the nervous system by "slow" virus: a study with scrapie agent. | 1969 | 5392819 | |
| the occurrence of nerve fiber degeneration in brains of mice inoculated with scrapie. | 1969 | 4185636 | |
| congenital rubella: the significance of virus persistence. | 1968 | 4304589 | |
| transmission of kuru to mice. | 1968 | 4171608 | |
| some factors controlling the incidence of scrapie in cheviot sheep injected with a cheviot-passaged scrapie agent. | 1968 | 4970193 | |
| slow, latent and temperate virus infections of the central nervous system. | 1968 | 4978852 | |
| glycosidase histochemistry in normal and scrapie mice, rats, sheep and goats. | 1968 | 5690819 | |
| orientated tubules in axoplasm of cerebellar myelinated nerve fibres in the rat. a study of normal and scrapie animals. | 1967 | 5624640 |