Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| human polyomaviruses and other human viruses in neuroendocrine tumors. | background: while the association of the merkel cell polyomavirus (mcv) with the neuroendocrine merkel cell carcinomas (mcc) has been shown recently, it is unknown whether other human polyomaviruses (hpyv) may be associated with neuroendocrine tumours (nets) of distinct entities. methods: using novel, highly sensitive polyomavirus genotyping assays, we evaluated the prevalence of eight distinct hpyvs in a selection of 51 nets from different entities. in addition, we analysed these nets for the p ... | 2011 | 21613390 |
| rkip downregulation induces the hbx-mediated raf-1 mitochondrial translocation. | the raf-1 kinase inhibitory protein (rkip) can regulate multiple key signaling pathways. specifically, rkip binds to raf-1 kinase and inhibits the ras-raf-1-mek1/2- erk1/2 pathway. additionally, raf-1 has been shown to translocate to mitochondria and thereby protect cells from stress-mediated apoptosis. recently, hbx was found to stimulate the mitochondrial translocation of raf-1, contributing to the anti-apoptotic effect. we found that rkip was downregulated during hbx-mediated hepatocarcinogen ... | 2011 | 21617351 |
| phosphorylation state-dependent interactions of hepadnavirus core protein with host factors. | dynamic phosphorylation and dephosphorylation of the hepadnavirus core protein c-terminal domain (ctd) are required for multiple steps of the viral life cycle. it remains unknown how the ctd phosphorylation state may modulate core protein functions but phosphorylation state-dependent viral or host interactions may play a role. in an attempt to identify host factors that may interact differentially with the core protein depending on its ctd phosphorylation state, pulldown assays were performed us ... | 2011 | 22216318 |
| [prevalences and risk factors associated with infection by human immunodeficiency virus, hepatitis b virus, syphilis and bacillary pulmonary tuberculosis in prisons in burkina faso]. | this purpose of this study was to determine prevalences and risk factors associated with infection by human immunodeficiency virus, hepatitis b virus, syphilis and bacillary pulmonary tuberculosis in prisons in burkina faso. from february 20 to march 20, 2009, 300 prisoners over 18 years of age held in ouagadougou were selected to take part in this descriptive and analytical cross-sectional study. sociodemographic data, confinement information (number, motive and prison time), medical history, s ... | 2011 | 22235618 |
| a selex-screened aptamer of human hepatitis b virus rna encapsidation signal suppresses viral replication. | the specific interaction between hepatitis b virus (hbv) polymerase (p protein) and the ε rna stem-loop on pregenomic (pg) rna is crucial for viral replication. it triggers both pgrna packaging and reverse transcription and thus represents an attractive antiviral target. rna decoys mimicking ε in p protein binding but not supporting replication might represent novel hbv inhibitors. however, because generation of recombinant enzymatically active hbv polymerase is notoriously difficult, such decoy ... | 2011 | 22125633 |
| hla-drb1*010101 allele is closely associated with poor virological response to lamivudine therapy in patients with chronic hepatitis b. | we intended to evaluate the association between specific human leukocyte antigen (hla)-drb1 gene polymorphism and antiviral response to lamivudine (lam) therapy in chronic hepatitis b (chb) patients. | 2011 | 22156484 |
| Donor Testing and Risk: Current Prevalence, Incidence, and Residual Risk of Transfusion-Transmissible Agents in US Allogeneic Donations. | Over the past 20 years, there has been a major increase in the safety of the blood supply, as demonstrated by declining rates of posttransfusion infection and reductions in estimated residual risk for such infections. Reliable estimates of residual risk have been possible within the American Red Cross system because of the availability of a large amount of reliable and consistent data on donations and infectious disease testing results. Among allogeneic blood donations, the prevalence rates of i ... | 2011 | 21871776 |
| a new risk factor for the development of non-alcoholic fatty liver disease: hla complex genes. | several studies have emphasized the role of genetic factors in susceptibility to non-alcoholic fatty liver disease. the aim of this study was to examine the possible influence of human leukocyte antigen in the development of non-alcoholic fatty liver disease. | 2011 | 21948570 |
| Recombinant adenovirus with human indoleamine-2,3-dioxygenase and hepatitis B virus preS was constructed and expressed in HepG2 cells. | Indoleamine-2,3-dioxygenase (IDO) is proven to suppress hepatitis B virus (HBV) specific immune response and depletion of IDO may be a useful approach for HBV therapy. To test this concept, we constructed recombinant adenovirus with human IDO and HBV preS, which would form the basis for future in vivo experiments. | 2011 | 22040572 |
| cost-effectiveness of additional blood screening tests in the netherlands. | background: during the past decade, blood screening tests such as triplex nucleic acid amplification testing (nat) and human t-cell lymphotropic virus type i or i (htlv-i/ii) antibody testing were added to existing serologic testing for hepatitis b virus (hbv), human immunodeficiency virus (hiv), and hepatitis c virus (hcv). in some low-prevalence regions these additional tests yielded disputable benefits that can be valuated by cost-effectiveness analyses (ceas). ceas are used to support decisi ... | 2011 | 21880046 |
| Protein-based nanotubes for biomedical applications. | This review presents highlights of our latest results of studies directed at developing protein-based smart nanotubes for biomedical applications. These practical biocylinders were prepared using an alternate layer-by-layer (LbL) assembly of protein and oppositely charged poly(amino acid) into a nanoporous polycarbonate (PC) membrane (pore diameter, 400 nm), with subsequent dissolution of the template. The tube wall typically comprises six layers of poly-l-arginine (PLA) and human serum albumin ... | 2011 | 22159164 |
| Is routine viral screening useful in patients with recent-onset polyarthritis of a duration of at least 6 weeks? Results from a nationwide longitudinal prospective cohort study. | To study the contribution of routine viral screening tests in patients with early rheumatoid arthritis (RA) or a potential for progressing to RA. | 2011 | 21954118 |
| immunostaining of pd-1/pd-ls in liver tissues of patients with hepatitis and hepatocellular carcinoma. | to investigate the expression of programmed death (pd)-1, pd ligand 1 (pd-l1) and pd-l2 in liver tissues in the context of chronic hepatitis and hepatocellular carcinoma (hcc). | 2011 | 21876620 |
| nuclear receptor mrna expression by hbv in human hepatoblastoma cell lines. | recent studies have implicated nuclear receptors (nrs) in the development of hepatocarcinogenesis. we assumed that hepatitis b virus (hbv) alters the expression of nrs and coregulators, and compared the gene expression profiling for 84 nrs and related genes between hpeg2.2.15, which secretes complete hbv virion, and hepg2 by real-time rt-pcr with sybr green. forty (47.6%) genes were upregulated 2-fold or greater, and only 5 (5.9%) were downregulated 2-fold or more, in hepg2.2.15 compared to hepg ... | 2011 | 21903321 |
| KIR and HLA loci are associated with hepatocellular carcinoma development in patients with hepatitis B virus infection: a case-control study. | Natural killer (NK) cells activation has been reported to contribute to inflammation and liver injury during hepatitis B virus (HBV) infection both in transgenic mice and in patients. However, the role of NK cells in the process of HBV-associated hepatocellular carcinoma (HCC) development has not been addressed. Killer cell immunoglobulin-like receptors (KIRs) are involved in regulating NK cell activation through recognition of specific human leukocyte antigen (HLA) class I allotypes. | 2011 | 21998681 |
| influence of chronic hbv infection on pregnancy: a human model of maternofetal virus host interactions. | 2011 | 21867707 | |
| is there need for a new hepatitıs b vaccine schedule for children with celiac disease? | celiac disease (cd) is an autoimmune disease characterized by immunemediated inflammatory damage of the small intestinal mucosa, precipitated by the ingestion of gluten-containing foods. since human leucocyte antigen dq2 (hla-dq2) is a marker of nonresponsiveness to hepatits b virus (hbv) vaccine, cd may also be associated with this nonresponsiveness. | 2011 | 22140387 |
| aflatoxin levels, plasma vitamins a and e concentrations, and their association with hiv and hepatitis b virus infections in ghanaians: a cross-sectional study. | micronutrient deficiencies occur commonly in people infected with the human immunodeficiency virus. since aflatoxin exposure also results in reduced levels of several micronutrients, hiv and aflatoxin may work synergistically to increase micronutrient deficiencies. however, there has been no report on the association between aflatoxin exposure and micronutrient deficiencies in hiv-infected people. we measured aflatoxin b1 albumin (af-alb) adduct levels and vitamins a and e concentrations in the ... | 2011 | 22078415 |
| antibody response following hepatitis b vaccination in peritoneal dialysis patients: does normalized urea clearance matter? | data on the factors that contribute to the antibody response to hepatitis b virus vaccination in peritoneal dialysis patients are scarce. the current study was conducted on a group of peritoneal dialysis patients to learn how the response to hepatitis b virus vaccination varies according to the patient's clearance of urea normalized to total body water (kt/v). | 2011 | 22179159 |
| [hepatitis c viruses infection situation in the human population of six provinces in china]. | to investigate the seroprevalence of hepatitis c viruse infection in the human population in six regions of beijing, heilongjiang, shandong, ningxia, gansu and sichuan in china. | 2011 | 22734232 |
| [a case of aids with pneumocystis jirovecii pneumonia which required differentiation from anca-related lung disease]. | a 41-year-old man with fever, diarrhea and skin rash received a diagnosis of drug-induced lupus. he was given corticosteroids for 3 months and was subsequently admitted to a local hospital due to dyspnea. pneumonia was then diagnosed and he was given a new quinolone antibacterial agent. despite this treatment, his symptoms and signs gradually worsened and he was referred to our hospital. high resolution ct (hrct) of the chest showed diffuse ground-glass opacities, reticular shadows, parenchymal ... | 2011 | 22352055 |
| [fulminant hepatic failure by hepatitis b virus in a patient with human immunodeficiency virus infection: report of one case]. | the human immunodeficiency virus (hiv) and hepatitis b virus (hbv) co-infection is a common problem in the world, with an estimated prevalence of up to 8%. we report a 27-year-old man admitted to the intensive care unit with an acute liver failure by hbv. during hospital stay, a co-infection with hiv virus was detected. treatment with early antiviral therapy was started with emtricitabine, tenofovir and raltegravir, to cover both hbv and hiv. despite therapy, the patient died two weeks after adm ... | 2011 | 22286734 |
| the role of sorafenib in downsizing hepatocellular carcinoma prior to liver transplantation and in treating tumor recurrence. | sorafenib is shown to improve survival in patients with advanced hepatocellular carcinoma (hcc). however, it has as yet not been tested in the liver transplantation (lt) setting. we report a 55-year-old man with multifocal hcc (stage b) related to hepatitis b virus cirrhosis (child-pugh b), initially treated with transarterial chemoembolization. after five months, sorafenib was added due to lack of response. this enhanced the downsizing of the tumor and eventually led to a surgically successful ... | 2011 | 24713719 |
| population attributable fraction of infection-related cancers in korea. | a number of infectious agents have been classified as human carcinogens. the purpose of the current study was to provide an evidence-based assessment of the burden of infection-related cancers in the korean population. materials and methods: the population attributable fraction was calculated using infection prevalence data from 1990 or earlier, relative risk estimates from meta-analyses using mainly korean studies and national data on cancer incidence and mortality for the year 2007. | 2011 | 20974652 |
| a common polymorphism in the abcb11 gene is associated with advanced fibrosis in hepatitis c but not in non-alcoholic fatty liver disease. | chronic hcv (hepatitis c virus)-associated cirrhosis represents a major indication for liver transplantation. bile acids contribute to hepatic stellate cell activation as a key event in fibrogenesis. the aim of the present study was to investigate the role of bile acids and polymorphisms in bile acid level-regulating genes on fibrosis progression. a total of 206 subjects with chronic hcv infection were included for abcb11 (atp-binding cassette, subfamily b, member ii) 1331t>c and nr1h4 (nuclear ... | 2011 | 20883210 |
| hepatitis b virus-associated hepatocellular carcinoma from india: role of viral genotype and mutations in ctnnb1 (beta-catenin) and tp53 genes. | chronic hepatitis b virus (hbv) infection is the major risk factor for hepatocellular carcinoma (hcc) in india. studies from other countries have linked hbv genotype c to a higher risk for hcc. this study was carried out to determine the association between genotype and hcc and also the frequency of mutations in ctnnb1 (beta-catenin) and tp53 genes in hbv-related hcc. | 2011 | 20963515 |
| hepatitis b virus acquisition and pathogenesis in childhood: host genetic determinants. | the clinical course of hepatitis b virus (hbv) infection varies from spontaneous recovery to chronic persistent infection leading to severe liver injury. mounting evidence has recently highlighted the influence of host genotype in the complex interplay between viral and host factors. studies in adults have suggested the existence of a genetic predisposition to hbv infection secondary to certain defects in the host response. these defects include opsonic deficiency, compromised antigen processing ... | 2011 | 21119536 |
| relative risk of reducing the lifetime blood donation deferral for men who have had sex with men versus currently tolerated transfusion risks. | the risks of known and emerging transfusion-transmitted infections (ttis) from reducing the current lifetime blood donation deferral for men who have had sex with men (msm) to 1 or 5 years were compared to the risk from continuing to transfuse in the united states 12.5% of platelet doses as pooled whole-blood-derived (rather than single-donor) platelets. assumptions made in mathematical models and blood donor/transfusion studies of the risks of ttis since 2000 were evaluated. the number of hiv, ... | 2011 | 21134626 |
| hepatitis b, hepatitis c and hiv transfusion-transmitted infections in the 21st century. | in the past, transfusion-transmitted virus (ttv) infections were not uncommon. in recent years with advanced technologies and improved donor screening, the risk of viral transfusion transmission has been markedly reduced. hepatitis b virus (hbv), hepatitis c virus (hcv) and human immunodeficiency virus (hiv) have all shown marked reduction in transmission rates. however, the newer technologies, including nucleic acid technology (nat) testing, have affected the residual rates differently for thes ... | 2011 | 21175659 |
| animal model for study of human hepatitis viruses. | human hepatitis b virus (hbv) and hepatitis c virus (hcv) infect only chimpanzees and humans. analysis of both viruses has long been hampered by the absence of a small animal model. the recent development of human hepatocyte chimeric mice has enabled us to carry out studies on viral replication and cellular changes induced by replication of human hepatitis viruses. various therapeutic agents have also been tested using this model. in the present review, we summarize published studies using chime ... | 2011 | 21175788 |
| hepatocellular carcinoma with persistent hepatitis b virus infection shows unusual downregulation of ras expression and differential response to ras mediated signaling. | persistent infection with hepatitis b virus (hbv) is a major etiological risk factor for hepatocellular carcinoma (hcc). the host cellular components involved in the progression of the carcinoma are still unclear. in the present study we aimed to evaluate ras mediated signaling in hepatocellular carcinoma with persistent hbv infection. | 2011 | 21175807 |
| [systematics and biology of the hepatitis viruses. like disease - different viruses]. | 2011 | 21194077 | |
| chronic viral hepatitis: epidemiology, molecular biology, and antiviral therapy. | viral hepatitis is a major cause of chronic liver disease, liver failure, and hepatocellular carcinoma worldwide, resulting in significant morbidity and mortality. new insights into the pathogenesis and molecular biology of hepatitis viruses have led to the discovery of novel antiviral agents. likewise, a greater understanding of the natural history of chronic infection, predictors of disease progression, and predictors of virologic response to therapy has resulted in more effective treatment st ... | 2011 | 21196168 |
| diagnosis and monitoring of chronic viral hepatitis: serologic and molecular markers. | chronic hepatitis b (hbv) and hepatitis c (hcv) virus infections are global health problems which may cause cirrhosis and even hepatocellular carcinoma. hepatitis d virus (hdv) though a satellite virus of hbv, can also cause chronic infection. serologic and molecular tools are needed for the diagnosis, monitoring and therapeutic management of chronic viral hepatitis associated with hbv, hdv and hcv. in hbv infection several serological markers are available for diagnosis and staging; while molec ... | 2011 | 21196366 |
| changing etiologies and outcomes of acute liver failure: a perspective from japan. | acute liver failure in japan usually consists of fulminant hepatitis (fh) due to viral infection, autoimmune hepatitis and drug-allergy-induced liver injury. the annual incidence of fh was estimated at 429 cases in 2004. fh is classified into acute or subacute type, and the prognosis of the latter is poor. hepatitis b virus (hbv) is the most frequently identifiable agent that causes fh in japan. transient hbv infection is more prevalent in the acute than subacute type, whereas the frequency of h ... | 2011 | 21199516 |
| treatment of chronic hepatitis b: evolution over two decades. | there has been a recent paradigm shift in the indications and endpoints of treatment for chronic hepatitis b (chb). hepatitis b e antigen (hbeag)-negative disease is being increasingly recognized. antiviral treatment for both hbeag-positive and hbeag-negative patients should aim at long-term suppression of hbv dna, with the ultimate ideal endpoint of hepatitis b surface antigen (hbsag) seroconversion. conventional interferon alpha (ifn-α), the only agent licensed in 1991, has been superseded by ... | 2011 | 21199525 |
| the difficulties of managing severe hepatitis b virus reactivation. | reactivation of hepatitis b is characterized by a sudden increase in hepatitis b virus (hbv) replication in a patient with prior evidence of resolved or inactive hbv infection. although hbv reactivation can occur spontaneously, it usually occurs after chemotherapy, immunosuppression (organ transplantation) or an alteration in immune function (therapy for autoimmune disease, human immunodeficiency virus infection). the clinical presentation cases can vary, ranging from a subclinical, asymptomatic ... | 2011 | 21205146 |
| the impact of human immunodeficiency virus on viral hepatitis. | the combination of antiretroviral (arv) therapies introduced at the end of the 1990s profoundly changed the natural history of human immunodeficiency virus (hiv) infection. liver diseases are one of the three primary causes of 'non-aids-related' death in people living with hiv for three reasons: the high prevalence of hepatotropic viral co-infections, the hepatotoxicity of arv drugs and new emerging liver diseases, including nodular regenerative hyperplasia and hepatitis e virus infection. the i ... | 2011 | 21205151 |
| hepatitis b virus (hbv) core antigen-specific regulatory t cells confer sustained remission to anti-hbv therapy in chronic hepatitis b with acute exacerbation. | acute exacerbations (aes) of chronic hepatitis b (ch-b) are thought to be the result of breakdown of immune tolerance on the natural history of chronic hepatitis b virus (hbv) infection. immune tolerance to hbv maintained in ch-b patients without hepatitis is under the control of the host's forkhead box p3-expressing regulatory t cells (tregs). its breakdown mimics the occurrence of autoimmune diseases. severe aes may lead to liver decompensation and mortalities. consequently, aes are currently ... | 2011 | 21215784 |
| the association of infection and clinical severity in sickle cell anaemia patients. | sickle cell anaemia (sca) patients have a high risk of infection. we retrospectively investigated the prevalence of infection among sca patients from bahia, brazil. a total of 1415 sca patients were studied between 1995 and 2009: 190 (13.4%) had hepatitis c virus (hcv), 67 (4.7%) had human t-lymphotropic virus type i (htlv-i), 44 (3.1%) had hepatitis b virus (hbv), 40 (2.8%) had chagas' disease, 11 (0.8%) had human immunodeficiency virus (hiv), and 5 (0.4%) had syphilis. patients with hcv infect ... | 2011 | 21216418 |
| population-based frequency assessment of hpv-induced lesions in patients with borderline pap tests in the emilia-romagna region: the pater study. | the pater study assessed the frequency of high-risk (hr) and low-risk (lr) human papillomavirus (hpv) in hpv-induced lesions in patients with borderline cytology. | 2011 | 21222568 |
| highly specific auto-antibodies against claudin-18 isoform 2 induced by a chimeric hbcag virus-like particle vaccine kill tumor cells and inhibit the growth of lung metastases. | strategies for antibody-mediated cancer immunotherapy, such as active immunization with virus-like particle (vlp)-based vaccines, are gaining increasing attention. we developed chimeric hepatitis b virus core antigen (hbcag)-vlps that display a surface epitope of the highly selective tumor-associated cell lineage marker claudin-18 isoform 2 (cldn18.2) flanked by a mobility-increasing linker. auto-antibodies elicited by immunization with these chimeric hbcag-vlps in 2 relevant species (mouse and ... | 2011 | 21224362 |
| building a comprehensive genomic program for hepatocellular carcinoma. | hepatocellular carcinoma (hcc) is the most common primary liver cancer, causing approximately 660,000 deaths worldwide annually. the preferred treatment of hcc is surgical resection or orthotopic liver transplantation (olt) for patients meeting specific criteria. for patients outside these criteria, options are limited and include medical therapy, radiofrequency ablation, chemoembolization, or palliative measures, and these result in poor outcomes. various centers at baylor are elucidating the g ... | 2011 | 21225260 |
| neurosyphilis manifesting with unilateral visual loss and hyponatremia: a case report. | syphilis is called the chameleon of the diseases due to its variety of its clinical presentations, potentially affecting every organ of the body. incidence of this ancient disease is once again on the increase worldwide. | 2011 | 21235811 |
| the x protein of hbv induces hiv-1 long terminal repeat transcription by enhancing the binding of c/ebpβ and creb1/2 regulatory proteins to the long terminal repeat of hiv-1. | due to share the route of transmission, the prevalence of co-infection of hepatitis b virus (hbv) and human immunodeficiency virus-1 (hiv-1) is high with chronic hbv infection affecting nearly 10% of hiv-infected patient world wide, which has become a significant global health problem. however, the cellular and molecular mechanisms associated with hbv/hiv-1 co-infection are largely unclear. in this study, we provided evidence that hbv induces hiv-1 transcription through its x protein (hbx). we f ... | 2011 | 21237225 |
| hepatitis b x-interacting protein induces hepg2 cell proliferation through activation of the phosphatidylinositol 3-kinase/akt pathway. | hepatitis b x-interacting protein (hbxip), a co-factor of survivin, was originally identified by its binding with the c-terminus of the hepatitis b virus x protein (hbx). we have recently shown that hbxip promotes the growth of both normal liver cells and hepatoma cells in vitro, but the molecular mechanisms of this have not been documented. in this study, we investigated the potential effects of hbxip on the proliferation of hepg2 cells and the intracellular signaling pathway mediating these ch ... | 2011 | 21239735 |
| viral hepatitis in solid organ transplantation other than liver. | transplantation is the best treatment for end-stage organ failure. hepatitis virus infections, mainly hepatitis b virus (hbv) and hepatitis c virus (hcv) infections still constitute a major problem because they are common in allograft recipients and are a significant cause of morbidity and mortality after transplantation. recently, hepatitis e virus infection has been added as an emergent cause of chronic hepatitis in organ transplantation. the prevalence of hbv and hcv infections has markedly d ... | 2011 | 21241754 |
| transmissibility of hepatitis b virus (hbv) infection through blood transfusion from blood donors with occult hbv infection. | studies of the transmissibility of hepatitis b virus (hbv) in occult hepatitis b (ohb) through blood transfusion are scarce. we aimed to determine the transmissibility of hbv in blood donors with ohb through transfusion in animal and human studies. | 2011 | 21245155 |
| hepatitis b virus lacks immune activating capacity, but actively inhibits plasmacytoid dendritic cell function. | chronic hepatitis b virus (hbv) infection is caused by inadequate anti-viral immunity. activation of plasmacytoid dendritic cells (pdc) leading to ifnα production is important for effective anti-viral immunity. hepatitis b virus (hbv) infection lacks ifnα induction in animal models and patients and chronic hbv patients display impaired ifnα production by pdc. therefore, hbv and hbv-derived proteins were examined for their effect on human pdc in vitro. in addition, the in vitro findings were comp ... | 2011 | 21246041 |
| nucleic acid testing to detect hbv infection in blood donors. | the detection of hepatitis b virus (hbv) in blood donors is achieved by screening for hepatitis b surface antigen (hbsag) and for antibodies against hepatitis b core antigen (anti-hbc). however, donors who are positive for hbv dna are currently not identified during the window period before seroconversion. the current use of nucleic acid testing for detection of the human immunodeficiency virus (hiv) and hepatitis c virus (hcv) rna and hbv dna in a single triplex assay may provide additional saf ... | 2011 | 21247314 |
| the x protein of hepatitis b virus inhibits apoptosis in hepatoma cells through enhancing the methionine adenosyltransferase 2a gene expression and reducing s-adenosylmethionine production. | the x protein (hbx) of hepatitis b virus (hbv) is involved in the development of hepatocellular carcinoma (hcc), and methionine adenosyltransferase 2a (mat2a) promotes the growth of liver cancer cells through altering s-adenosylmethionine homeostasis. thus, we speculated that a link between hbx and mat2a may contribute to hcc development. in this study, the effects of hbx on mat2a expression and cell apoptosis were investigated, and the molecular mechanism by which hbx and mat2a regulate tumorig ... | 2011 | 21247894 |
| occult hepatitis b virus infection in thai blood donors. | an evaluation by the national blood center, the thai red cross society, of two commercial multiplex nucleic acid tests (nats; the chiron procleix ultrio test and the roche cobas taqscreen mpx test) for screening thai blood donors for hepatitis b virus (hbv), hepatitis c virus, and human immunodeficiency virus type 1 identified 175 hbv nat-reactive/hepatitis b surface antigen (hbsag)-negative donors. the classification of the hbv infection of these donors was confirmed by follow-up testing. | 2011 | 21251005 |
| recombinant heat shock protein 65 carrying padre and hbv epitopes activates dendritic cells and elicits hbv-specific ctl responses. | bcg hsp65 and padre have been shown to be potent to enhance antigen specific immunity. in order to explore the possibility to utilize them for the development of hbv therapeutic vaccine, a chimeric protein, hsp65-hbv, was created by fusing padre and epitopes from hbv to the carboxyl-terminus of bcg hsp65 and expressed in e. coli. we evaluated its effects on human dendritic cell maturation and specific ctl induction in vitro. results showed that hsp65-hbv could activate human dendritic cells by u ... | 2011 | 21251902 |
| hepatitis b virus and cancer prevention. | prevention of chronic hepatitis b virus (hbv) infection can successfully reduce the incidence of liver cancer. it is the first example of cancer-preventive vaccine in human, which proves that prevention of the infection of an infectious agent can prevent its related cancer.chronic hbv infection can lead to chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma (hcc). hcc is one of the five major cancers in the world population. hepatitis b virus (hbv) is the most important etiologic ag ... | 2011 | 21253790 |
| practical techniques to enhance the safety of health care workers in office-based surgery. | background: office-based surgery is commonly practiced in different specialties for a variety of procedures. during these procedures, the health care worker (hcw) is exposed to a large number of pathogens that can be bloodborne, including the hepatitis b virus (hbv), hepatitis c virus (hcv), and human immunodeficiency virus (hiv). these pathogens can be transmitted through needlesticks or sharp injuries to intact skin or by backsplash of contaminated body fluids onto mucous membranes or injured ... | 2011 | 21291655 |
| efficacy and safety of subcutaneous human hbv-immunoglobulin (zutectra) in liver transplantation: an open, prospective, single-arm phase iii study. | hepatitis b re-infection prophylaxis is crucial for graft and recipient survival for transplanted patients and is administered routinely after liver transplantation for hepatitis b. aim of the current study was the investigation of efficacy, safety and feasibility of home-treatment of a novel human hepatitis b immunoglobulin bt088 (zutectra) after weekly subcutaneous application in liver-transplanted patients. a total of 23 patients (5 female, 18 male, median age 51 years) were enrolled and swit ... | 2011 | 21294780 |
| new perspectives on the evolutionary history of hepatitis b virus genotype f. | hepatitis b virus (hbv) is a globally distributed human pathogen. the aim of this work was to analyze the evolutionary history of hbv genotype f, emphasizing on the study of subgenotypes prevalent in the southern area of south america. complete genomes of hbv genotype f from 36 samples from argentina and chile were sequenced and analyzed by phylogenetic and bayesian coalescent methods along with sequences obtained from genbank database. the phylogeography separated not only central american from ... | 2011 | 21296172 |
| [use of illicit drugs over gestation and their neonatal impact. comparison between periods 1982-1988 and 2002-2008]. | the use of illicit drugs during pregnancy becomes a high risk situation. our objective is to determine the currently prevalence, pregnancy, delivery and newborn's characteristics of mothers who use illicit drugs. | 2011 | 21296368 |
| epidemiology and prevention of viral infections in patients with hematologic malignancies. | viral infections are some of the most frequent complications in patients with hematologic malignancies are viral infections. infections caused by cytomegalovirus, herpes simplex virus, varicella zoster virus, hepatitis b virus and influenza virus are associated with high morbidity and mortality in this vulnerable population. fortunately, a growing number of antiviral medications and vaccines are allowing for more effective prophylaxis against these pathogens. this article reviews the epidemiolog ... | 2011 | 21303338 |
| prevalence of hepatitis b surface antigen (hbsag) among visitors of shashemene general hospital voluntary counseling and testing center. | 2011 | 21303563 | |
| circulating tregs correlate with viral load reduction in chronic hbv-treated patients with tenofovir disoproxil fumarate. | limited response to current hepatitis b virus (hbv) drugs is possibly due to inadequate host cytotoxic cellular responses. circulating tregs have been shown to be associated with chronicity of hbv infection, but their profile during antiviral therapy has not been studied. we analyzed the frequency and effect of tregs on cellular immune responses against hbv in 35 chronic hepatitis b eag-ve and eag+ve patients treated with tenofovir 300 mg/day. frequency of tregs and their modulatory role in cyto ... | 2011 | 21305387 |
| oncogenic virus-mediated cell fusion: new insights into initiation and progression of oncogenic viruses--related cancers. | cell fusion is fundamental to the development and physiology of multicellular organisms, such as fertilization, placentation, development of skeletal muscle and bone. oncogenic virus-mediated cell fusion, however, may lead to chromosomal instability (cin) by various mechanisms when tumor suppressor p53 is deregulated and produce oncogenic aneuploid cells. it is worth noting that all human oncogenic viruses, including human papillomavirus (hpv), hepatitis b virus (hbv), hepatitis c virus (hcv), e ... | 2011 | 21306823 |
| rpb5-mediating protein is required for the proliferation of hepatocellular carcinoma cells. | rpb5-mediating protein (rmp) is associated with the rna polymerase ii subunit rpb5. rmp functionally counteracts the transcriptional activation of hepatitis b virus x protein that has been shown to play a role in the development of hepatocellular carcinoma (hcc). however, the effect of rmp on the growth of hcc remains unclear. in this study, we characterized the potential role of rmp in the proliferation of human hcc cells using two cell lines, smmc-7721 and hepg2. we found that rmp expression i ... | 2011 | 21310960 |
| human microrna hsa-mir-125a-5p interferes with expression of hepatitis b virus surface antigen. | micrornas are small non-coding rnas that modulate gene expression at post-transcriptional level, playing a crucial role in cell differentiation and development. recently, some reports have shown that a limited number of mammalian micrornas are also involved in anti-viral defense. in this study, the analysis of the hepatitis b virus (hbv) genome by the computer program miranda led to the identification of seven sites that are potential targets for human liver micrornas. these sites were found to ... | 2011 | 21317190 |
| reciprocal changes of naïve and effector/memory cd8+ t lymphocytes in chronic hepatitis b virus infection. | persistent viruses, such as cytomegalovirus or human immunodeficiency virus, cause major perturbations of cd8+ t-lymphocyte subpopulations. to test whether chronic infection with hepatitis b virus (hbv) could also be responsible for such modifications, we analyzed the expression of cd27, cd28, ccr7, and perforin in blood cd8+ t lymphocytes. in comparison to healthy subjects and patients recovering from acute hepatitis b, chronic hepatitis b patients showed higher percentages of naïve cd8+ t lymp ... | 2011 | 21319976 |
| natural history of chronic hepatitis b revealed. | chronic hepatitis b is a worldwide public health challenge. knowledge of natural history of chronic hepatitis b is important for the management of the disease. a community-based prospective cohort study was carried out to evaluate the risk predictors of progression of chronic hepatitis b in taiwan. a total of 23,820 participants were enrolled in 1991-1992 from seven townships in taiwan. their serum samples were collected at study entry and tested for hepatitis b surface antigen (hbsag) and e ant ... | 2011 | 21323729 |
| hepatitis b virus x protein overcomes all-trans retinoic acid-induced cellular senescence by downregulating levels of p16 and p21 via dna methylation. | despite current molecular evidence suggesting that hepatitis b virus (hbv) x protein (hbx) plays an important role during hbv-mediated hepatocarcinogenesis, the detailed mechanism is still controversial. here, it was shown that hbx overcomes cellular senescence provoked by all-trans retinoic acid (atra) in hepg2 cells, as demonstrated by the impaired induction of irreversible g(1) arrest and senescence-associated ß-galactosidase activity by atra in the presence of hbx. the anti-senescence effect ... | 2011 | 21325480 |
| prevalence and association of human parvovirus b19v with hepatitis b and c viruses in nigeria. | co-infection of parvovirus b19 with hepatitis b virus has been found in patients with acute and chronic hepatitis. the clinical significance of parvovirus b19 in hepatitis b co-infected patients is still controversial. in this study parvovirus b19 antibodies and dna were investigated in serum samples from 76 patients with hbv infection, 17 with hbv/hcv co-infection and 44 healthy controls. in the sera from patients with hbv infection, anti-b19v igm and igg antibodies were detected in 24/76 (32%) ... | 2011 | 21328387 |
| parvovirus 4 in french in-patients: a study of hemodialysis and lung transplant cohorts. | the epidemiology and the clinical implication of human parvovirus 4 (parv4) in human populations is still under evaluation. the distribution of parv4 dna was determined in cohorts of french hemodialysis and lung transplant patients. plasma samples (n=289) were tested for parv4 by real-time pcr assay (orf2), and amplification products selected at random were sequenced. analysis of available serological and biological markers was also undertaken. fifty-seven samples out of 185 (30.8%) were positiv ... | 2011 | 21328388 |
| seroprevalence of hiv-1, hbv, htlv-1 and treponema pallidum among pregnant women in a rural hospital in southern ethiopia. | human immunodeficiency virus type 1 (hiv-1), hepatitis b virus (hbv), human t-cell lymphotropic virus type 1 (htlv-1) and treponema pallidum represent major public health problems in sub-saharan countries. these infections can be transmitted from mother to children and may cause severe morbidities in their offspring. ethiopia is among the countries where hiv-1, hbv and t. pallidum infections are highly prevalent. however, information on seroprevalence of these infections among antenatal care att ... | 2011 | 21330196 |
| hbx-induced androgen receptor expression in hbv-associated hepatocarcinoma is independent of the methylation status of its promoter. | a remarkable feature of hbv-associated hcc is male predominance. the cooperation of hepatitis b virus x protein (hbx) with androgen receptor (ar) signaling pathway has been documented to contribute to this dominance. hbx, a multifunctional viral regulator, has been documented to induce promoter hypermethylation and low expression of tumor suppressor genes via activation of dna methyl-transferase (dnmt) in hepatocarcinogenesis. in prostate cancer, hypermethylation of ar promoter is associated wit ... | 2011 | 21117024 |
| primary central nervous system lymphoma in acquired immune deficiency syndrome mimicking toxoplasmosis. | a 37-year-old man, a hepatitis b virus carrier due to mother-to-child transmission, had a medical examination in september 2008 in nearby hospitals due to anorexia and weight loss. he was transported to our hospital because computed tomography (ct) detected intracranial lesions, and he had a positive human immunodeficiency virus (hiv) antibody test. head computed tomography (ct) revealed multiple hemorrhagic lesions and enhancement effect, suggesting a thin wall. also, an enhancement effect was ... | 2011 | 21210240 |
| amendments to hypotheses on the proximate causes of variation in human sex ratios at birth with parental infection with hepatitis b virus or toxoplasma gondii. | in a recent paper in this journal, i offered hypotheses on the offspring sex ratios of women infected with the parasite toxoplasma gondii, and on the offspring sex ratios of people who are carriers of hepatitis b virus (hbv) (james, 2008). subsequent research suggests that these hypotheses need amending. a detailed account of the amendments is given elsewhere in a specialized journal (james, 2010a). here they are summarized. | 2011 | 21211089 |
| frequency of blood-borne viral infections among leukemic patients in central iraq. | to determine the prevalence of hepatitis b virus (hbv), hepatitis c virus (hcv), cytomegalovirus (cmv), epstein-barr virus (ebv), and human immunodeficiency virus (hiv) and other epidemiological criteria among leukemic patients to establish basic knowledge for future leukemic patients care. | 2011 | 21212918 |
| no evidence of the unfolded protein response in patients with chronic hepatitis c virus infection. | hepatitis c virus (hcv) proteins activate the unfolded protein response (upr) in experimental models. the role of the upr in the pathogenesis of hcv-induced liver injury has not been determined. our aim was to investigate the role of the upr in the pathogenesis of chronic hcv. | 2011 | 21261722 |
| prevalence of hbv infection among different hiv-risk groups in hai phong, vietnam. | hepatitis b virus (hbv) infection in hai phong, northern vietnam, was characterized by analyzing the prevalence and genotype distribution of hbv as well as co-infection with human immunodeficiency virus type 1 (hiv-1) among five different risk groups for hiv infection. plasma samples were collected from intravenous drug users (n=760, anti-hiv-1 antibody positive rate: 35.9%), female sex workers (fsws; n=91, 23.1%), seafarers (n=94, 0%), pregnant women (n=200, 0.5%), and blood donors (n=210, 2.9% ... | 2011 | 21264859 |
| overexpression of thy1/cd90 in human hepatocellular carcinoma is associated with hbv infection and poor prognosis. | thy1/cd90 is an important marker of many types of stem cells. it functions as a tumor suppressor in ovarian cancer and in nasopharyngeal carcinoma. in this study, the expression status of thy1 in clinical hepatocellular carcinoma (hcc) tissue samples was investigated. relationships of thy1 expression with clinical parameters and patient survival rate were analyzed. the quantities of thy1 mrna were statistically higher in tumor tissues than those in the adjacent non-tumor tissues (p<0.001). immun ... | 2011 | 21272924 |
| strong influence of human leukocyte antigen (hla)-dp gene variants on development of persistent chronic hepatitis b virus carriers in the han chinese population. | chronic hepatitis b virus (hbv) infection is a major health issue, especially in asia. a recent genome-wide association study (gwas) implicated genetic variants in the human leukocyte antigen (hla)-dp locus associated with chronic hepatitis b in japanese and thai populations. to confirm whether the polymorphisms at the hla-dp genes are associated with persistent chronic hbv infection in han chinese, we conducted an independent case-control study using 521 persistent chronic hbv carriers and 819 ... | 2011 | 21274863 |
| no associations of polymorphisms in adprt with hepatitis b virus clearance and hepatocellular carcinoma occurrence in a korean population. | aim: the human adenosine diphosphate ribosyl transferase (adprt) gene might significantly affect cancer by encoding poly(adp-ribose) polymerase 1 enzyme (parp-1) and promoting an important role in cellular responses to dna damage, genomic stabilization and regulation of tumor suppressor genes. we explored whether polymorphisms of adprt affect clearance of hepatitis b virus (hbv) infection or risk of hepatocellular carcinoma (hcc) occurrence in a korean hbv cohort. methods: genotyping was perfo ... | 2011 | 21276153 |
| oxymatrine inhibits hepatitis b infection with an advantage of overcoming drug-resistance. | oxymatrine (omtr) is an anti-hepatitis drug used in china. its mechanism of action is unknown. recently, we found that omtr inhibits hepatitis b virus (hbv) via down-regulating the expression of heat-stress cognate 70 (hsc70), a host protein required for hbv dna replication. goal of this study was to assess the effect of omtr on clinical hbv drug-resistance. omtr monotherapy (oral, 12 months) reduced blood hbv dna by 96% and hbeag by 70% in the chronic hepatitis b (chb) patients resistant to lam ... | 2011 | 21277330 |
| [preliminary investigation of viruses to the wild tree shrews (tupaia belangeri chinese)]. | virological testing and monitoring is a fundamental part of quality control of experimental animals. however, there are few papers regarding the spectrum and status of natural infection in wild tree shrews with human and animal pathogenic viruses. using enzyme-linked immunosorbent adsorption assay (elisa), we tested sixty wild tree shrews captured from qinglong, an outskirt region of kunming, yunnan province, china for eleven viruses, including herpes simplex virus, coxsackie virus, influenza vi ... | 2011 | 21341387 |
| virus trap in human serum albumin nanotube. | infectious hepatitis b virus (hbv), namely dane particles (dps), consists of a core nucleocapsid including genome dna covered with an envelope of hepatitis b surface antigen (hbsag). we report the synthesis, structure, and hbv-trapping capability of multilayered protein nanotubes having an anti-hbsag antibody (hbsab) layer as an internal wall. the nanotubes were prepared using an alternating layer-by-layer assembly of human serum albumin (hsa) and oppositely charged poly-l-arginine (pla) into a ... | 2011 | 21341767 |
| chromosome remodeling related to hepatitis b virus replication in hepg2 cells. | hepatitis b virus (hbv) covalently closed circular dna (cccdna) is the main replicative intermediate of hbv and is organized into minichromosomes by the interaction with histone and nonhistone proteins. the remodeling of hbv minichromosomes such as post-translational modifications of histone proteins plays an important role in regulating hbv replication. to determine whether other remodeling occurs in addition to acetylation of cccdna-bound h3 histones in the presence of hbv replication, a cell ... | 2011 | 21345131 |
| hepatitis b virus protein up-regulated hlj1 expression via the transcription factor yy1 in human hepatocarcinoma cells. | the hepatitis b virus (hbv) protein plays a major role in hepatocellular carcinoma (hcc) development. however, its contribution to tumor invasion and metastasis has not been established so far. hlj1 was recently cloned and classified as a member of the heat shock protein 40 family (hsp40/dnaj) which is abundantly expressed in hbv-related tumors, might be involved in tumor progression. in this study, the role of hbv in activation of hlj1 was investigated. in hepg2 cells with transit or stable exp ... | 2011 | 21345358 |
| risk alleles for chronic hepatitis b are associated with decreased mrna expression of hla-dpa1 and hla-dpb1 in normal human liver. | a genome-wide association study identified single nucleotide polymorphisms (snps) rs3077 and rs9277535 located in the 3' untranslated regions of human leukocyte antigen (hla) class ii genes hla-dpa1 and hla-dpb1, respectively, as the independent variants most strongly associated with chronic hepatitis b. we examined whether these snps are associated with mrna expression of hla-dpa1 and hla-dpb1. we identified gene expression-associated snps (esnps) in normal liver samples obtained from 651 indiv ... | 2011 | 21346778 |
| hepatitis associated aplastic anemia: a review. | hepatitis-associated aplastic anemia (haaa) is an uncommon but distinct variant of aplastic anemia in which pancytopenia appears two to three months after an acute attack of hepatitis. haaa occurs most frequently in young male children and is lethal if leave untreated. the etiology of this syndrome is proposed to be attributed to various hepatitis and non hepatitis viruses. several hepatitis viruses such as hav, hbv, hcv, hdv, hev and hgv have been associated with this set of symptoms. viruses o ... | 2011 | 21352606 |
| kaposi's sarcoma-associated herpesvirus infection in chinese patients with chronic hepatitis b. | the seroprevalence of kaposi's sarcoma-associated herpesvirus (kshv) in chinese patients with chronic hepatitis b, the relationship between kshv and hepatitis b virus (hbv) infection, and the influence of glycyrrhizic acid on kshv replication in vivo are undefined. plasma was collected from 211 patients with chronic hepatitis b. antibody to kshv orf65 was evaluated by elisa, and real-time pcr was used to quantify kshv dna and hbv dna. the kshv orf65 positivity rate in patients with chronic hepat ... | 2011 | 21360542 |
| role of the coinhibitory receptor cytotoxic t lymphocyte antigen-4 on apoptosis-prone cd8 t cells in persistent hepatitis b virus infection. | an excess of coinhibitory signals has been proposed to drive the t-cell exhaustion characteristic of persistent viral infections. in this study we examined the contribution of the coinhibitory receptor cytotoxic t lymphocyte antigen-4 (ctla-4) to cd8 t cell tolerance in chronic hepatitis b virus (hbv) infection (chb). cd8 t cells in patients with chb have an increased propensity to express the coinhibitory receptor ctla-4 and this correlates with viral load. ctla-4 is up-regulated on those hbv-s ... | 2011 | 21360567 |
| hepatitis b virus limits response of human hepatocytes to interferon-a in chimeric mice. | interferon (ifn)-a therapy is not effective for most patients with chronic hepatitis b virus (hbv) infection for reasons that are not clear. we investigated whether hbv infection reduced ifn-a-mediated induction of antiviral defense mechanisms in human hepatocytes. | 2011 | 21376046 |
| hepatitis b virus x protein is essential to initiate and maintain virus replication after infection. | background & aims: the molecular biology of hepatitis b virus (hbv) has been extensively studied but the exact role of the hepatitis b x protein (hbx) in the context of natural hbv infections remains unknown. methods: primary human hepatocytes and differentiated heparg cells allowing conditional trans complementation of hbx were infected with wild type (hbv(wt)) or hbx deficient (hbv(x-)) hbv particles and establishment of hbv replication was followed. results: we observed that cells inoculated ... | 2011 | 21376091 |
| impaired hepatitis b vaccine responses during chronic hepatitis c infection: involvement of the pd-1 pathway in regulating cd4(+) t cell responses. | vaccination for hepatitis b virus (hbv) in the setting of hepatitis c virus (hcv) infection is recommended, but responses to vaccination are blunted when compared to uninfected populations. the mechanism for this failure of immune response in hcv-infected subjects remains unknown but is thought to be a result of lymphocyte dysfunction during chronic viral infection. we have recently demonstrated that pd-1, a novel negative immunomodulator for t cell receptor (tcr) signaling, is involved in t and ... | 2011 | 21376795 |
| n-linked glycan changes of serum haptoglobin +¦ chain in liver disease patients. | human haptoglobin is a serum glycoprotein secreted by the liver with four potential n-glycosylation sites on its +¦ chain. many studies have reported glycan changes of haptoglobin in diseases such as breast cancer and pancreatic cancer. the objective of our study is to analyze n-linked glycan alterations of serum haptoglobin +¦ chain obtained from patients with the hepatitis b virus (hbv), liver cirrhosis (lc) and hepatocellular carcinoma (hcc). maldi-qit-tof mass spectrometry revealed the inten ... | 2011 | 21380457 |
| phenotype, function, and gene expression profiles of programmed death-1(hi) cd8 t cells in healthy human adults. | t cell dysfunction is an important feature of many chronic viral infections. in particular, it was shown that programmed death-1 (pd-1) regulates t cell dysfunction during chronic lymphocytic choriomeningitis virus infection in mice, and pd-1(hi) cells exhibit an intense exhausted gene signature. these findings were extended to human chronic infections such as hiv, hepatitis c virus, and hepatitis b virus. however, it is not known if pd-1(hi) cells of healthy humans have the traits of exhausted ... | 2011 | 21383243 |
| screening of hepatitis b and c and human immunodeficiency virus in infertile couples in saudi arabia. | to determine the prevalence of hepatitis b virus (hbv), hepatitis c virus (hcv), and human immunodeficiency virus (hiv) in a group of infertile couples attending a tertiary care facility in saudi arabia. | 2011 | 21384061 |
| shooting up: the interface of microbial infections and drug abuse. | illicit drug control has been on the global agenda for more than a century. infections have long been recognized as one of the most serious complications of drug abuse. drug users are susceptible to pulmonary, endovascular, skin and soft tissue, bone and joint, and sexually transmitted infections caused by a wide range of bacterial, viral, fungal and protozoal pathogens. in addition, injection drug users are at increased risk for parenterally acquired infections such as human immunodeficiency vi ... | 2011 | 21389334 |
| resection of hepatocellular carcinoma recurring in the diaphragm after right hepatic lobectomy. | we describe a 35-year-old man with hepatocellular carcinoma (hcc) that recurred in the diaphragm after right hepatic lobectomy. the patient had undergone right hepatic lobectomy for hcc with chronic hepatitis b virus infection 1 year previously. on pathological examination, the tumor measured 15 +ù 14.4 +ù 11 cm and was moderately well differentiated. the surgical margins were negative. after 1 year, computed tomography of the abdomen revealed a mass extending from the right side of the diaphrag ... | 2011 | 21389645 |
| il-21 is pivotal in determining age-dependent effectiveness of immune responses in a mouse model of human hepatitis b. | hbv is a noncytopathic hepadnavirus and major human pathogen that causes immune-mediated acute and chronic hepatitis. the immune response to hbv antigens is age dependent: viral clearance occurs in most adults, while neonates and children usually develop chronic infection and liver disease. here, we characterize an animal model for hbv infection that recapitulates the key differences in viral clearance between early life and adulthood and find that il-21 may be part of an effective primary hepat ... | 2011 | 21393863 |
| [ten years of nucleic acid testing: lessons and prospects]. | nucleic acid testing has been routinely performed in all blood donations in france since july 1st 2001. this is the story of a controversial decision. "the unacceptable hiv risk" in the context of the early 2000s influenced the decision. the results achieved over these past 10 years are analyzed given the expected progress of this new screening tool for infectious agents in transfusion. they confirm the relevance of models used by experts in 2000. out of 22.3 million donations over the period (2 ... | 2011 | 21397544 |
| oncogenetic tree modeling of human hepatocarcinogenesis. | classical comparative genomic hybridization (cgh) has been used to identify recurrent genomic alterations in human hcc. as hepatocarcinogenesis is considered as a stepwise process, we applied oncogenetic tree modeling on all available classical cgh data to determine occurrence of genetic alterations over time. nine losses (1p, 4q, 6q, 8p, 9p, 13q, 16p, 16q and 17p) and ten gains (1q, 5p, 6p, 7p, 7q, 8q, 17q, 20p, 20q and xq) of genomic information were used to build the oncogenetic tree model. w ... | 2011 | 21400513 |
| [retroperitoneal metastasis of hepatocellular carcinoma - a case report]. | the patient was a 54-year-old man. he was an hbv carrier, and hepatocellular carcinoma (hcc) was detected for the first time in 2000. an operation was performed, but hcc recurred. after repeating the operation and transarterial chemo-embolization (tace) for the recurrent hcc, a tumor was found in january 2009 on the ventral side of the right kidney, and we thought it was a retroperitoneal metastasis of hcc or peritoneal dissemination. he was enrolled in a trial of systemic chemotherapy, called " ... | 2011 | 21403456 |