Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| prevalence and prognostic significance of epstein-barr virus infection in classical hodgkin's lymphoma: a meta-analysis. | the prevalence and prognostic significance of epstein-barr virus (ebv) infection in classical hodgkin's lymphomas (chls) remain elusive. to examine the epidemiological and prognostic differences between ebv-positive and -negative chls, we conducted a meta-analysis of 119 published studies including 13,045 cases. | 2014 | 24937173 |
| prospective monitoring of cytomegalovirus, epstein-barr virus, bk virus, and jc virus infections on belatacept therapy after a kidney transplant. | few data regarding viral replication in patients receiving belatacept are available. the aim of this single-center study was to compare the incidence of viral infections (cytomegalovirus, epstein barr virus, bk virus, and jc virus), in 62 de novo kidney transplant patients enrolled in the benefit studies, receiving either belatacept (n=42) or cyclosporine (n=20). | 2014 | 24907721 |
| radiosensitization effect of nedaplatin on nasopharyngeal carcinoma cells in different status of epstein-barr virus infection. | this study aims to evaluate the radiosensitization effect of nedaplatin on nasopharyngeal carcinoma (npc) cell lines with different epstein-barr virus (ebv) status. human npc cell lines cne-2 (ebv-negative) and c666 (ebv-positive) were treated with 0-100 μg/ml nedaplatin, and inhibitory effects on cell viability and ic50 were calculated by mts assay. we assessed changes in radiosensitivity of cells by mts and colony formation assays, and detected the apoptosis index and changes in cell cycle by ... | 2014 | 24900979 |
| prognostic factors in epstein-barr virus-associated stage i-iii gastric carcinoma: implications for a unique type of carcinogenesis. | epstein-barr virus-associated gastric carcinoma (ebvagc) has distinct clinicopathological features. however, the prognostic factors remain unclear, particularly in uicc/ajcc stage i-iii cancer. we retrospectively enrolled 1,020 patients with stage i-iii gastric cancer that received radical gastrectomy with lymphadenectomy. formalin-fixed, paraffin‑embedded surgical specimens were retrieved to construct tissue microarrays. ebv positivity was identified by in situ hybridization with ebv-encoded sm ... | 2014 | 24899228 |
| microrna mir-bart20-5p stabilizes epstein-barr virus latency by directly targeting bzlf1 and brlf1. | epstein-barr virus (ebv) is a human herpesvirus associated with various tumors. rather than going through the lytic cycle, ebv maintains latency by limiting the expression of viral genes in tumors. viral micrornas (mirnas) of some herpesviruses have been reported to directly target immediate early genes and suppress lytic induction. in this study, we investigated whether bamhi-a rightward transcript (bart) mirnas targeted two ebv immediate early genes, bzlf1 and brlf1. bioinformatic analysis pre ... | 2014 | 24899173 |
| epstein-barr virus, the germinal centre and the development of hodgkin's lymphoma. | the relationship between epstein-barr virus (ebv) and the germinal centre (gc) of the asymptomatic host remains an enigma. the occasional appearance of ebv-positive germinal centres in some patients, particularly those with a history of immunosuppression, suggests that ebv numbers in the gc are subject to immune control. the relationship, if any, between lymphoid hyperplasia with ebv-positive germinal centres and subsequent or concurrent lymphomagenesis remains to be clarified. as far as the dev ... | 2014 | 24893782 |
| ebv & hhv6 reactivation is infrequent and not associated with ms clinical course. | among the environmental factors associated with multiple sclerosis (ms) causation, some of the strongest associations are with epstein-barr virus (ebv), and to a lesser extent human herpesvirus 6 (hhv6). associations with clinical course are less conclusive, however. | 2014 | 24893674 |
| implication of epstein-barr virus infection in disease-specific autoreactive b cell activation in ectopic lymphoid structures of sjögren's syndrome. | to examine whether the b cell tropic γ-herpesvirus epstein-barr virus (ebv) is aberrantly expressed in its latent and lytic forms within ectopic lymphoid structures (els) in the salivary glands of patients with sjögren's syndrome (ss), and to investigate the relationship between ebv dysregulation, b cell activation, in situ differentiation of autoreactive plasma cells, disease-specific autoantibody production, and cytotoxicity. | 2014 | 24891330 |
| editorial: what caused all these troubles, anyway? epstein-barr virus in sjögren's syndrome reevaluated. | 2014 | 24891328 | |
| hydroa vacciniforme and solar urticaria. | hydroa vacciniforme (hv) and solar urticaria (su) are uncommon immunologically mediated photodermatoses. hv occurs almost exclusively in children, usually beginning in childhood and remitting spontaneously by adolescence. association with chronic epstein-barr virus infection has been reported in hv, which raises the possibility of lymphoproliferative disorders in these patients. su is characterized by skin erythema, swelling, and whealing immediately after sun exposure. although several treatmen ... | 2014 | 24891056 |
| epstein-barr virus viral load and serology in childhood non-hodgkin's lymphoma and chronic inflammatory conditions in uganda: implications for disease risk and characteristics. | epstein-barr virus (ebv) has been linked to malignancies and chronic inflammatory conditions. in this study, ebv detection was compared in children with non-hodgkin's lymphoma and children with chronic inflammatory conditions, using samples and data from a case-control study carried out at the mulago national referral hospital between 2004 and 2008. ebv viral load was measured in saliva, whole blood and white blood cells by real-time pcr. serological values for igg-vca, ebna1, and ead-igg were c ... | 2014 | 24889739 |
| [epidemiology and anatomy of head and neck cancers]. | oral cavity and pharyngeal cancers account for 75% of head and neck cancers and are the fourth most spread cancer in men. their incidence has decreased since 1980 in men (incidence from 2011 gives 13,930 for lip, oral cavity, pharyngeal and laryngeal carcinomas) but has increased in women, linked to the more recent smoking or alcohol intoxication in women. in addition to the smoking or alcohol consumption risk factors, the ebv role in nasopharyngeal carcinomas, hpv in the oropharyngeal carcinoma ... | 2014 | 24886890 |
| how do viruses trick b cells into becoming lymphomas? | since the discovery of epstein-barr virus in burkitt's lymphoma 50 years ago, only one other virus, namely kaposi's sarcoma-associated herpesvirus/human herpesvirus-8, has been confirmed to be a direct cause of b-cell lymphoma. here we will review the evidence for epstein-barr virus and kaposi's sarcoma-associated herpesvirus as causal lymphoma agents. | 2014 | 24886824 |
| difference in cytokine production and cell cycle progression induced by epstein-barr virus lmp1 deletion variants in kmh2, a hodgkin lymphoma cell line. | epstein-barr virus (ebv) is associated with 20-40% of hodgkin's lymphoma (hl) cases. ebv-encoded latent membrane protein 1 (lmp1) is a well-known oncogenic protein and two c-terminal deletion variants, del30-lmp1 and del69-lmp1, have been described in animal models to be more tumorigenic than the wild-type form. this work aims to detail the implication of lmp1 in the development of hl and to characterize the particular effects of these variants. | 2014 | 24886620 |
| oral lymphomatoid granulomatosis, the first sign of a 'rare disease': a case report. | lymphomatoid granulomatosis is an uncommon epstein-barr virus-positive b-cell lymphoma, an angiocentric-destructive process with a predominant t-cell background. lymphomatoid granulomatosis is listed among rare diseases. common localization is in the lungs. lymphomatoid granulomatosis with oral involvement is described in only two reports. in this report, we describe a third case of oral lymphomatoid granulomatosis. | 2014 | 24886196 |
| primary extranodal nk/t cell lymphoma, nasal-type of uterus with adenomyosis: a case report. | natural killer (nk)/t cell lymphoma of the female genital tract is extremely rare. we here report a case of 'nasal type' nk/t cell lymphoma arising in the uterus with adenomyosis in a 41-year-old woman with fever and hypogastralgia. the histologic analysis demonstrated a highly aggressive tumor with characteristic angiocentric/angiodestructive growth pattern and focal necrosis. the lymphoma cells displayed a cd3ϵ/cd56/tia-1/granzyme-b/perforin-positive and cd20/cd79a/cd4/cd8-negative immunopheno ... | 2014 | 24886075 |
| rheumatoid arthritis/methotrexate-associated primary cutaneous diffuse large b-cell lymphoma, leg type. | this report concerns a 62-year-old man with primary cutaneous diffuse large b-cell lymphoma (pclbcl), leg type that developed during methotrexate (mtx) treatment for rheumatoid arthritis (ra). several tumors were observed on the left lower leg. a histological analysis showed diffuse proliferation of large neoplastic b-cells that were immunophenotypically cd10-/mum1+/bcl6-/bcl2+ and cytogenetically had igh/c-myc translocation without translocation involving bcl6 or igh/bcl2. no evidence of epstei ... | 2014 | 24881744 |
| primary natural killer/t-cell lymphoma presenting as leptomeningeal disease. | primary central nervous system natural killer/t-cell lymphoma (primary-cns-nk/tcl) is a rare non-hodgkin's lymphoma. to our knowledge, only five patients have been described previously, all of whom were male, with brain parenchymal involvement and previous epstein-barr virus infection, it has never been reported to present as leptomeningeal disease as our case. our objective is to report a rare case of primary-cns-nk/tcl presenting as leptomeningeal disease and to share our diagnostic/therapeuti ... | 2014 | 24880537 |
| a hyper-ferritinemia syndrome evolving in recurrent macrophage activation syndrome, as an onset of amyopathic juvenile dermatomyositis: a challenging clinical case in light of the current diagnostic criteria. | juvenile dermatomyositis is an immune-mediated inflammatory multi-system disease involving mainly striated muscles and skin. typical dermatological features are fundamental to establish the diagnosis, especially whenever the myopathy is very mild or absent, as it occurs in the form called as amyopathic juvenile dermatomyositis. sometimes, systemic rheumatic diseases can develop a hyperferritinemia syndrome characterized by hemophagocytosis, namely macrophage activation syndrome, which represents ... | 2014 | 24879966 |
| clinical value of serum epstein-barr virus dna assay in the diagnosis of nasopharyngeal carcinoma. | serum epstein-barr virus dna has been approved for diagnosing nasopharyngeal carcinoma (npc). the goal of this meta-analysis was to evaluate the clinical value of the serum epstein-barr virus dna in the diagnosis of npc. the pubmed, embase, web of knowledge, chinese wanfang med online, and national knowledge infrastructure (cnki) databases were searched to identify suitable studies. the pooled sensitivity, specificity, positive likelihood ratio (lr+), negative likelihood ratio (lr-), and diagnos ... | 2014 | 24879626 |
| three different histological subtypes of epstein-barr virus-negative post-transplant lymphoproliferative disorder in a patient with hepatitis c infection. | we report a rare case in which epstein-barr virus (ebv)-negative polymorphic b-cell post-transplant lymphoproliferative disorder (ptld) and ebv-negative monomorphic t-cell ptld [anaplastic lymphoma kinase (alk)-positive anaplastic large cell lymphoma (alcl)] were observed simultaneously in the same cervical lymph node, 34 months after liver transplantation for hepatitis c liver cirrhosis. although hepatitis c recurred after 2 months, he had no other complications until ptld occurred 34 months po ... | 2014 | 24879033 |
| identifying predictive factors for posttransplant lymphoproliferative disease in pediatric solid organ transplant recipients with epstein-barr virus viremia. | epstein-barr virus (ebv) viremia (ev) in pediatric solid organ transplant (sot) recipients is a significant risk factor for posttransplant lymphoproliferative disease (ptld) but not all patients with ev develop ptld. we identify predictive factors for ptld in patients with ev. we conducted a retrospective chart review of all pediatric sot recipients (0 to 21 y) at a single institution between 2001 and 2009. a total of 350 pediatric patients received a sot and 90 (25.7%) developed ev. of ev patie ... | 2014 | 24878618 |
| evaluation of a semi-quantitative elisa for iga antibody against epstein-barr virus capsid antigen in the serological diagnosis of nasopharyngeal carcinoma. | this study was designed to establish an elisa method, as well as the cut-off value, for iga against epstein-barr virus (ebv) viral capsid antigen (vca), as a screening assay for nasopharyngeal carcinoma (npc) in southern china. in addition, the correlation between relative optical density (rod) values from elisa and titers from the immunoenzymatic assay (iea) was also evaluated. | 2014 | 24878579 |
| squamous cell carcinoma variants of the upper aerodigestive tract: a comprehensive review with a focus on genetic alterations. | squamous cell carcinoma of the upper aerodigestive tract is a heterogenous entity. although conventional squamous cell carcinomas are easily recognized, the morphologic variants of squamous cell carcinoma can present a diagnostic challenge. familiarity with these variants is necessary because many are associated with unique risk factors and are characterized by specific molecular alterations (eg, nuclear protein in testis midline carcinomas). perhaps the most important distinction is in identify ... | 2014 | 24878013 |
| prognostic significance of p16 and its relationship with human papillomavirus in pharyngeal squamous cell carcinomas. | the prognostic significance of p16 in squamous cell carcinoma (scc) of the hypopharynx (hp) and nasopharynx (np) and relationship between human papillomavirus (hpv) and p16 is unclear. | 2014 | 24876098 |
| acalculous cholecystitis or biliary dyskinesia for epstein-barr virus gallbladder involvement? | we present two patients with epstein-barr virus (ebv) infection related to gallbladder involvement. such an association is already known as ebv induced acalculous cholecystitis, diagnosed on the basis of ultrasonographic findings. in our patients, radioisotopic cholescintigraphy was also performed and it showed that gallbladder was visualized in both patients in contrast to that what can be observed in cases of cholecystitis. however, the value of ejection fraction was compatible with biliary dy ... | 2014 | 24874936 |
| a multifactorial role for p. falciparum malaria in endemic burkitt's lymphoma pathogenesis. | endemic burkitt's lymphoma (ebl) arises from the germinal center (gc). it is a common tumor of young children in tropical africa and its occurrence is closely linked geographically with the incidence of p. falciparum malaria. this association was noted more than 50 years ago. since then we have learned that ebl contains the oncogenic herpes virus epstein-barr virus (ebv) and a defining translocation that activates the c-myc oncogene. however the link to malaria has never been explained. here we ... | 2014 | 24874410 |
| uracil dna glycosylase bkrf3 contributes to epstein-barr virus dna replication through physical interactions with proteins in viral dna replication complex. | epstein-barr virus (ebv) bkrf3 shares sequence homology with members of the uracil-n-glycosylase (ung) protein family and has dna glycosylase activity. here, we explored how bkrf3 participates in the dna replication complex and contributes to viral dna replication. exogenously expressed flag-bkrf3 was distributed mostly in the cytoplasm, whereas bkrf3 was translocated into the nucleus and colocalized with the ebv dna polymerase balf5 in the replication compartment during ebv lytic replication. t ... | 2014 | 24872582 |
| retrograde analysis of clinical characteristics of bone metastasis in 1,031 cases of preliminarily diagnosed nasopharyngeal carcinoma. | to explore the clinical characteristics of bone metastasis (bm) in a large sample of preliminarily diagnosed nasopharyngeal carcinomas (npcs). | 2014 | 24870794 |
| clinical roundtable monograph: cd30 in lymphoma: its role in biology, diagnostic testing, and targeted therapy. | cd30, a member of the tumor necrosis factor receptor superfamily, is a transmembrane glycoprotein receptor consisting of an extracellular domain, a transmembrane domain, and an intracellular domain. cd30 has emerged as an important molecule in the field of targeted therapy because its expression is generally restricted to specific disease types and states. the major cancers with elevated cd30 expression include hodgkin lymphoma and anaplastic large t-cell lymphoma, and cd30 expression is conside ... | 2014 | 24870054 |
| an association between bk virus replication in bone marrow and cytopenia in kidney-transplant recipients. | the human polyomavirus bk (bkv) is associated with severe complications, such as ureteric stenosis and polyomavirus-associated nephropathy (pvan), which often occur in kidney-transplant patients. however, it is unknown if bkv can replicate within bone marrow. the aim of this study was to search for bkv replication within the bone marrow of kidney-transplant patients presenting with a hematological disorder. seventy-two kidney-transplant patients underwent bone-marrow aspiration for cytopenia. at ... | 2014 | 24868448 |
| follicular dendritic cell sarcoma of the inflammatory pseudotumor-like variant presenting as a colonic polyp. | follicular dendritic cell (fdc) sarcoma is rare and is classified either as conventional type or inflammatory pseudotumor (ipt)-like variant. extranodal presentation is uncommon and nearly all gastrointestinal fdc tumors are of the conventional type. ipt-like variant tumors occur almost exclusively in the liver and spleen and are consistently associated with epstein-barr virus (ebv). here we report the case of a 78-year-old woman with an ipt-like fdc sarcoma presenting as a pedunculated colonic ... | 2014 | 24868227 |
| current concepts in primary effusion lymphoma and other effusion-based lymphomas. | primary effusion lymphoma (pel) is a human herpes virus 8 (hhv8)-positive large b-cell neoplasm that presents as an effusion with no detectable tumor in individuals with human immunodeficiency virus infection or other immune deficiencies. pel is an aggressive neoplasm with a poor prognosis. pel cells show diverse morphologies, ranging from immunoblastic or plasmablastic to anaplastic. the immunophenotype of pel is distinct, but its lineage can be misdiagnosed if not assessed thoroughly. pel cell ... | 2014 | 24868220 |
| differential requirement for p2x7r function in il-17 dependent vs. il-17 independent cellular immune responses. | il17-dependent autoimmunity to collagen type v (col v) has been associated with lung transplant obliterative bronchiolitis. unlike the t helper 1 (th1)-dependent immune responses to tetanus toxoid (tt), the th17 response to col v in lung transplant patients and its th1/17 variant observed in coronary artery disease patients requires il-1β, tumor necrosis factor α and cd14(+) cells. given the involvement of the p2x7 receptor (p2x7r) in monocyte il-1β responses, we investigated its role in th17-, ... | 2014 | 24866539 |
| utility of quantitative ebv dna measurements in cerebrospinal fluid for diagnosis and monitoring of treatment of central nervous system ebv-associated post-transplant lymphoproliferative disorder after allogenic hematopoietic stem cell transplantation. | epstein-barr virus (ebv)-associated post-transplant lymphoproliferative disorder (ptld) after hematopoietic stem cell transplantation (hsct) is a rare but life- threatening condition. despite routine ebv dna-emia monitoring in blood, central nervous system involvement of the disease is still associated with diagnostic difficulties and poor outcome. | 2014 | 24866354 |
| virus-encoded micrornas facilitate gammaherpesvirus latency and pathogenesis in vivo. | gammaherpesviruses, including epstein-barr virus (ebv), kaposi sarcoma-associated herpesvirus (kshv, or hhv-8), and murine gammaherpesvirus 68 (mhv68, γhv68, or muhv-4), are b cell-tropic pathogens that each encode at least 12 micrornas (mirnas). it is predicted that these regulatory rnas facilitate infection by suppressing host target genes involved in a wide range of key cellular pathways. however, the precise contribution that gammaherpesvirus mirnas make to viral life cycle and pathogenesis ... | 2014 | 24865551 |
| epstein-barr virus as a paradigm in nasopharyngeal cancer: from lab to clinic. | nasopharyngeal carcinoma (npc) of the undifferentiated subtype remains endemic in southern china, with a peak incidence in this region approaching 30 cases per 100,000 population per year. despite advances in chemotherapy and radiation delivery techniques in localized disease, distant metastasis is still common and npc remains the seventh leading cause of cancer death in the region. there is great need for early diagnosis, developing novel therapies, and identifying patients with localized disea ... | 2014 | 24857071 |
| virus and autoantigen-specific cd4+ t cells are key effectors in a scid mouse model of ebv-associated post-transplant lymphoproliferative disorders. | polyclonal epstein-barr virus (ebv)-infected b cell line (lymphoblastoid cell lines; lcl)-stimulated t-cell preparations have been successfully used to treat ebv-positive post-transplant lymphoproliferative disorders (ptld) in transplant recipients, but function and specificity of the cd4+ component are still poorly defined. here, we assessed the tumor-protective potential of different cd4+ t-cell specificities in a ptld-scid mouse model. injection of different virus-specific cd4+ t-cell clones ... | 2014 | 24853673 |
| detection of a specific biomarker for epstein-barr virus using a polymer-based genosensor. | this paper describes methodology for direct and indirect detections of a specific oligonucleotide for epstein-barr virus (ebv) using electrochemical techniques. the sequence of oligonucleotide probe (ebv1) revealed a high sequence identity (100%) with the ebv genome. for the development of the genosensor, ebv1 was grafted to the platform sensitized with poly(4-aminothiophenol). after that, the hybridization reaction was carried out with the complementary target (ebv2) on the modified electrode s ... | 2014 | 24853286 |
| epstein-barr virus-positive nodular lymphocyte predominant hodgkin lymphoma. | hodgkin lymphoma (hl) is classified into 2 largely distinct subgroups, namely nodular lymphocyte predominant hl (nlphl) and classic hl (chl). chl is further divided into nodular sclerosis, lymphocyte-rich, mixed cellularity (mcchl) and lymphocyte-depleted (ldchl) subtypes. in industrialized nations, epstein-barr virus (ebv) has been associated with all types of chl, especially the mcchl and ldchl subtypes, but is rare in nlphl. we report 8 cases of ebv-positive nlphl occurring in patients in the ... | 2014 | 24852241 |
| a single amino acid in ebna-2 determines superior b lymphoblastoid cell line growth maintenance by epstein-barr virus type 1 ebna-2. | sequence differences in the ebna-2 protein mediate the superior ability of type 1 epstein-barr virus (ebv) to transform human b cells into lymphoblastoid cell lines compared to that of type 2 ebv. here we show that changing a single amino acid (s442d) from serine in type 2 ebna-2 to the aspartate found in type 1 ebna-2 confers a type 1 growth phenotype in a lymphoblastoid cell line growth maintenance assay. this amino acid lies in the transactivation domain of ebna-2, and the s442d change increa ... | 2014 | 24850736 |
| epstein-barr virus serology as a potential screening marker for nasopharyngeal carcinoma among high-risk individuals from multiplex families in taiwan. | nasopharyngeal carcinoma (npc) is an epstein-barr virus (ebv)-associated cancer that is highly treatable when diagnosed early, with 5-year disease-free survival of approximately 90%. however, npc is typically diagnosed at advanced stages, in which disease-free survival is <50%. there is, therefore, a need for clinical tools to assist in early npc detection, particularly among high-risk individuals. | 2014 | 24769890 |
| arid1a/baf250a as a prognostic marker for gastric carcinoma: a study of 2 cohorts. | arid1a/baf250a has been recently implicated as a tumor suppressor in gastric cancer. we sought to clarify the clinical significance of baf250a/arid1a in relation to other clinical parameters and relevant biomarkers in gastric carcinoma. cases from 2 separate cohorts of patients with gastric carcinoma from vancouver (n = 173) and toronto (n = 80) were selected for the construction of tissue microarrays, which were used to assess the immunohistochemical status of baf250a (anti-arid1a), mismatch re ... | 2014 | 24767857 |
| primary undifferentiated carcinoma of the trachea. | primary undifferentiated or lymphoepithelial carcinoma mainly occurs in the nasopharynx. tracheal localization is exceedingly rare. to the best of our knowledge, only four cases have been reported previously, all in asian patients. | 2014 | 24765831 |
| primary burkitt's lymphoma of the thyroid without epstein-barr virus infection: a case report and literature review. | primary thyroid lymphomas are rare, and the majority are b-cell lymphoma. primary burkitt's lymphoma (bl) of the thyroid is much less common than the other types of lymphoma. the current study presents the case of an eight-year-old male with a mass in the right lobe of the thyroid, which was detected by b-ultrasound. the patient was diagnosed with bl by immunohistochemistry, fluorescence in situ hybridization analysis of myc (8q24) and immunoglobulin rearrangement assays. furthermore, subsequent ... | 2014 | 24765169 |
| cd30(+) extranodal natural killer/t-cell lymphoma mimicking phlegmonous myositis: a case report. | the current study presents a case of a 23-year-old male with cd30(+) nasal-type extranodal natural killer/t-cell lymphoma (nktl), with unusual clinical features mimicking phlegmonous myositis. the patient initially presented with swelling and tenderness of the left lower limb, particularly around the left ankle. one month later, pharyngalgia and fever developed and the patient was treated with antibiotics for the phlegmonous inflammation, however, the symptoms were not relieved. a muscle biopsy ... | 2014 | 24765148 |
| discerning primary tumors from metastases in synchronous nasopharyngeal squamous cell carcinoma and cutaneous squamous cell carcinoma: a case report and review of the literature. | nasopharyngeal carcinoma is one of the most common types of malignant tumor in southern china and southeast asia, and its etiology is closely associated with epstein-barr virus (ebv) infection. non-keratinizing carcinoma accounts for >95% of all nasopharyngeal carcinoma cases. in addition, metastatic nasopharyngeal carcinoma from other locations in the body is extremely rare. this study reports the case of a 53-year-old female who presented with a lesion on the left nasal alar skin that had slow ... | 2014 | 24765143 |
| human b cell-derived lymphoblastoid cell lines constitutively produce fas ligand and secrete mhcii(+)fasl(+) killer exosomes. | immune suppression mediated by exosomes is an emerging concept with potentially immense utility for immunotherapy in a variety of inflammatory contexts, including allogeneic transplantation. exosomes containing the apoptosis-inducing molecule fas ligand (fasl) have demonstrated efficacy in inhibiting antigen-specific immune responses upon adoptive transfer in animal models. we report here that a very high frequency of human b cell-derived lymphoblastoid cell lines (lcl) constitutively produce mh ... | 2014 | 24765093 |
| epstein-barr virus-negative post-transplant lymphoproliferative diseases: three distinct cases from a single center. | three cases of epstein-barr virus (ebv)-negative post-transplant lymphoproliferative disease that occurred 6 to 8 years after renal transplantation are reported. the patients respectively had gastric mucosa-associated lymphoid tissue lymphoma, gastric diffuse large b-cell lymphoma, and atypical burkitt lymphoma. absence of ebv in the tissue samples was demonstrated by both in situ hybridization for ebv early rna and polymerase chain reaction for ebv dna. patients were treated with reduction in i ... | 2014 | 24764734 |
| viruses as potential pathogenic agents in systemic lupus erythematosus. | genetic and environmental factors appear to contribute to the pathogenesis of systemic lupus erythematosus (sle). viral infections have been reported to be associated with the disease. a number of exogenous viruses have been linked to the pathogenesis of sle, of which epstein-barr virus (ebv) has the most evidence of an aetiological candidate. in addition, human endogenous retroviruses (herv), hres-1, erv-3, herv-e 4-1, herv-k10 and herv-k18 have also been implicated in sle. hervs are incorporat ... | 2014 | 24763543 |
| in vivo intratumoral epstein-barr virus replication is associated with xbp1 activation and early-onset post-transplant lymphoproliferative disorders with prognostic implications. | post-transplant lymphoproliferative disorders are life-threatening complications following hematopoietic or solid organ transplantation. they represent a spectrum of mostly ebv-driven lymphoplasmacytic proliferations. while the oncogenic effect of ebv is related to latent infection, lytic infection also has a role in lymphomagenesis. in vitro, ebv replication is linked to plasma cell differentiation and xbp1 activation, although this phenomenon has never been addressed in vivo. we analyzed for t ... | 2014 | 24762547 |
| epstein-barr virus–associated lymphocytosis masquerading as lymphoma. | 2014 | 24761435 | |
| contribution of il-12/il-35 common subunit p35 to maintaining the testicular immune privilege. | the testis is an organ with immune privilege. the comprehensive blood-testis barrier formed by sertoli cells protects autoimmunogenic spermatozoa and spermatids from attack by the body's immune system. the interleukin (il)-6/il-12 family cytokines il-12 (p35/p40), il-23 (p19/p40), il-27 (p28/epstein-barr virus-induced gene 3 [ebi3]), and il-35 (p35/ebi3) play critical roles in the regulation of various immune responses, but their roles in testicular immune privilege are not well understood. in t ... | 2014 | 24760014 |
| identification of protein kinase inhibitors with a selective negative effect on the viability of epstein-barr virus infected b cell lines. | epstein-barr virus (ebv) is a human herpesvirus, which is causally associated with the development of several b lymphocytic malignancies that include burkitt's lymphomas, hodgkin's disease, aids and posttransplant associated lymphomas. the transforming activity of ebv is orchestrated by several latent viral proteins that mimic and modulate cellular growth promoting and antiapoptotic signaling pathways, which involve among others the activity of protein kinases. in an effort to identify small mol ... | 2014 | 24759913 |
| synchronous hiv/aids-related epstein-barr virus-associated smooth muscle tumors in a 20-year-old female. | we present a case of simultaneous endobronchial and adrenal epstein-barr virus-associated smooth muscle tumors in a 20-year-old female with aids. blood epstein-barr virus polymerase chain reaction was negative at the time of diagnosis. | 2014 | 24759574 |
| a molecular basis for the interplay between t cells, viral mutants, and human leukocyte antigen micropolymorphism. | mutations within t cell epitopes represent a common mechanism of viral escape from the host protective immune response. the diverse t cell repertoire and the extensive human leukocyte antigen (hla) polymorphism across populations is the evolutionary response to viral mutation. however, the molecular basis underpinning the interplay between hla polymorphism, the t cell repertoire, and viral escape is unclear. here we investigate the t cell response to a hla-b*35:01- and hla-b*35:08-restricted (40 ... | 2014 | 24759101 |
| epstein-barr virus-positive diffuse large b-cell lymphoma in an elderly patient. | epstein-barr virus-positive (ebv) diffuse large b-cell lymphoma (dlcbl) of the elderly is a newly described lymphoproliferative disorder that arises in elderly patients without a predisposing immunodeficiency. clinical features at presentation may include lymphadenopathy, b-symptoms and extranodal involvement. the main sites of extranodal involvement are the skin, lung, tonsil and stomach. histopathological findings include atypical large lymphoid cells with variable amounts of reactive cells, s ... | 2014 | 24758493 |
| lymphoepithelial carcinoma of the salivary gland: morphologic patterns and imaging features on ct and mri. | lymphoepithelial carcinoma is a rare salivary gland lesion. we retrospectively reviewed ct and mr imaging features of salivary gland lymphoepithelial carcinoma to determine their imaging features and morphologic patterns. | 2014 | 24831594 |
| series of extranodal natural killer/t-cell lymphoma, nasal type, with periorbital involvement. | to describe the clinical presentation, diagnosis and treatment of periorbital extranodal natural killer/t-cell lymphoma, nasal type. | 2014 | 24831171 |
| identification of properties of the kaposi's sarcoma-associated herpesvirus latent origin of replication that are essential for the efficient establishment and maintenance of intact plasmids. | the maintenance of latent kaposi's sarcoma-associated herpesvirus (kshv) genomes is mediated in cis by their terminal repeats (tr). a kshv genome can have 16 to 50 copies of the 801-bp tr, each of which harbors a 71-bp-long minimal replicator element (mre). a single mre can support replication in transient assays, and the presence of as few as two trs appears to support establishment of kshv-derived plasmids. why then does kshv have such redundancy and heterogeneity in the number of trs? by dete ... | 2014 | 24829342 |
| a biocultural perspective on fictive kinship in the andes: social support and women's immune function in el alto, bolivia. | this article examines the influence of emotional and instrumental support on women's immune function, a biomarker of stress, in the city of el alto, bolivia. it tests the prediction that instrumental support is protective of immune function for women living in this marginal environment. qualitative and quantitative ethnographic methods were employed to assess perceived emotional and instrumental support and common sources of support; multiple linear regression analysis was used to model the rela ... | 2014 | 24824579 |
| primary ebv-positive hodgkin's lymphoma of the cns under azathioprine treatment: case report and review of the literature. | retrospective and prospective cohort studies suggest that central nervous system involvement occurs in approximately 0.5% of patients with advanced hodgkin's lymphoma. the isolated primary intracranial manifestation of hodgkin's lymphoma is an extremely rare finding, with few cases reported in the literature. little is known about the optimal treatment and prognosis of these tumors. here, we present a case report with a review of the literature. | 2014 | 24823896 |
| antiviral activity of topoisomerase ii catalytic inhibitors against epstein-barr virus. | herpesviruses require several cellular proteins for their lytic dna replication including topoisomerase ii (topo ii). thus, topo ii could be an effective drug target against herpesviral infection. in this study, we examined several topo ii catalytic inhibitors for their potentials in blocking ebv replication and becoming efficacious antiviral agents. topo ii catalytic inhibitors in general exhibited marked inhibition of ebv lytic replication and minimal cytotoxicity. in particular, (+)-rutamarin ... | 2014 | 24821256 |
| post-kidney transplant large bowel lymphoproliferative disorder. | epstein-barr virus (ebv)-associated post-transplant lymphoproliferative disorder (ptld) is a serious complication of organ transplantation. the gastrointestinal (gi) tract is a common site involved, but non-specific signs and symptoms often delay the diagnosis. we report a case of ebv-associated gi-ptld in a 68-year-old kidney transplant patient who received the kidney ten months earlier. he presented with chronic diarrhea and developed massive pneumo-peritoneum secondary to multiple colonic per ... | 2014 | 24821162 |
| age-specific prevalence of epstein-barr virus infection among minnesota children: effects of race/ethnicity and family environment. | primary epstein-barr virus (ebv) infection affects the host differently according to when in life it is acquired. understanding risk factors for infection could be important for disease prevention, and the age-specific prevalence of infection must be known to optimize use of a prophylactic vaccine. | 2014 | 24820696 |
| occurrence of epstein-barr virus-associated plasmacytic lymphoproliferative disorder after antithymocyte globulin therapy for aplastic anemia: a case report with review of the literature. | it is well established that patients with immunosuppression have a higher risk of development of lymphoproliferative disorders (lpds), and epstein-barr virus (ebv) is associated with development of lpds. aplastic anemia (aa) is an immune-mediated hematological disorder, and immunosuppression therapy (ist), such as antithymocyte globulin (atg), is widely used for treatment of aa. however, occurrence of lpd without bone marrow transplantation has been extremely rarely documented in patients with i ... | 2014 | 24817974 |
| diffuse alveolar damage in a patient with epstein barr virus (ebv)-positive diffuse large b-cell lymphoma,severely low serum folate, and megaloblastic anemia: a case report of autopsy. | we report a case of a 49-year-old japanese man, who was admitted to our hospital because of severe dyspnea. he was found to have severely low serum folate and megaloblastic anemia, which was at first suspected to cause his dyspnea. it was assumed that severely low serum folate might be related to his malnutrition, probably caused by habitual alcohol consumption. he died in several days because of acute respiratory distress syndrome. autopsy revealed diffuse alveolar damage (dad) in the lungs and ... | 2014 | 24817973 |
| metastatic cervical carcinoma from an unknown primary: literature review. | carcinoma of an unknown primary (cup) encompasses a heterogeneous group of tumors for which no primary site can be detected following a thorough history, physical examination, and noninvasive and invasive testing. cup presenting with metastasis to the neck (metastatic cervical carcinoma from an unknown primary [mccup]) has been an enigma since von volkmann first described it in 1882 as a cancer arising in a branchial cleft cyst. genetic studies have shed some light on this unusual entity. in mos ... | 2014 | 24817234 |
| stable dna methylation boundaries and expanded trinucleotide repeats: role of dna insertions. | the human genome segment upstream of the fmr1 (fragile x mental retardation 1) gene (xq27.3) contains several genetic signals, among them is a dna methylation boundary that is located 65-70 cpgs upstream of the cgg repeat. in fragile x syndrome (fxs), the boundary is lost, and the promoter is inactivated by methylation spreading. here we document boundary stability in spite of critical expansions of the cgg trinucleotide repeat in male or female premutation carriers and in high functioning males ... | 2014 | 24816393 |
| epstein-barr virus infection in adult renal transplant recipients. | epstein-barr virus (ebv) dnaemia in the first year posttransplantation has been studied extensively. there is a paucity of information on prevalence and sequelae of ebv infection in adult renal transplantation beyond the first year. this single-center study examines the relationship between ebv dnaemia and demographic, immunosuppressive, hematologic and infection-related parameters in 499 renal transplant recipients between 1 month and 33 years posttransplant. participants were tested repeatedly ... | 2014 | 24815922 |
| animal models of epstein barr virus infection. | epstein barr virus (ebv) was the first human tumor virus to be identified. despite 50years of research on this oncogenic virus, no therapeutic or prophylactic vaccine is available against this pathogen. in part, the development of such a vaccine is hampered by the lack of in vivo models for ebv infection and immune control. however, with the advent of mice with reconstituted human immune system components (his mice), certain aspects of ebv associated diseases and immune responses can be modeled ... | 2014 | 24815603 |
| multiple functions are mediated by the mirnas of epstein-barr virus. | epstein-barr virus is a gammaherpes virus that is causally associated with several malignancies and expresses multiple mirnas in both normal and tumor cells. since the identification of virally encoded mirnas, various mrnas have been identified as targets for regulation by ebv's mirnas in host cells. we shall summarize these targets, the robustness of their identification, and examine how the regulation of these targets by ebv contributes to the successful infection of its host. | 2014 | 24814666 |
| nasal type extranodal nk/t cell lymphoma diagnosed in a patient with rheumatoid arthritis under methotrexate. | rheumatoid arthritis (ra) patients have increased risk of lymphoma which seems associated mainly with high inflammatory state and disease activity, but also with immunosuppressive agents or epstein-barr virus (ebv) infection. many case reports describe lymphoproliferative lesions arising during methotrexate therapy, often ebv positive with possible regression after methotrexate withdrawal. the authors report the case of an 85-year-old patient with erosive and seronegative ra, in remission under ... | 2014 | 24811465 |
| methotrexate-associated lymphoproliferative disorder arising in the retromolar triangle and lung of a patient with rheumatoid arthritis. | we report an extremely rare case of massive methotrexate-associated lymphoproliferative disorder (mtx-lpd) arising in the retromolar triangle and lung of a patient with rheumatoid arthritis. the patient was a 75-year-old woman who was referred to our department because of severe pain associated with a unilateral ulcer on the left retromolar triangle. the tumor had an extranodal location in the retromolar triangle and in the right lung. a clinicopathologic examination found a lymphocytic infiltra ... | 2014 | 24811204 |
| oxysterol-ebi2 signaling in immune regulation and viral infection. | the seven transmembrane g protein-coupled receptor epstein-barr virus (ebv) induced gene 2 (ebi2; also known as gpr183) was identified in 1993 on the basis of its substantial upregulation in ebv-infected cells. it is primarily expressed in lymphoid cells; most abundantly in b cells. ebi2 is central for the positioning of b cells within the lymphoid organs, a process that is regulated in part by a chemotactic gradient formed by the endogenous lipid agonists, and in part by a fine-tuned regulation ... | 2014 | 24810762 |
| comparative evaluation of the new architect ebv assays considering different testing algorithms. | in the current evaluation, epstein-barr virus (ebv) serology was performed on 1113 routine serum samples. although the initial request for all samples from the general practitioner was ebv igm testing, 80.9% were classified as past infections. the architect(®) viral capsid antigen (vca) igm, vca igg, and ebv nuclear antigen (ebna) 1 igg assays showed good results for sensitivity and specificity, being 100.0%, 98.3%, and 100.0% and 99.9%, 95.4%, and 99.6%, respectively. using an algorithm based o ... | 2014 | 24809858 |
| epstein-barr virus down-regulates tumor suppressor dok1 expression. | the dok1 tumor suppressor gene encodes an adapter protein that acts as a negative regulator of several signaling pathways. we have previously reported that dok1 expression is up-regulated upon cellular stress, via the transcription factor e2f1, and down-regulated in a variety of human malignancies due to aberrant hypermethylation of its promoter. here we show that epstein barr virus (ebv) infection of primary human b-cells leads to the down-regulation of dok1 gene expression via the viral oncopr ... | 2014 | 24809689 |
| activation and repression of epstein-barr virus and kaposi's sarcoma-associated herpesvirus lytic cycles by short- and medium-chain fatty acids. | the lytic cycles of epstein-barr virus (ebv) and kaposi's sarcoma-associated herpesvirus (kshv) are induced in cell culture by sodium butyrate (nab), a short-chain fatty acid (scfa) histone deacetylase (hdac) inhibitor. valproic acid (vpa), another scfa and an hdac inhibitor, induces the lytic cycle of kshv but blocks ebv lytic reactivation. to explore the hypothesis that structural differences between nab and vpa account for their functional effects on the two related viruses, we investigated t ... | 2014 | 24807711 |
| cns lymphoma: a practical diagnostic approach. | the concept and understanding of central nervous system (cns) lymphoma have greatly evolved in the past few years. better characterization of a number of lymphoproliferative neoplasms through clinical, immunophenotyping, and molecular studies is reflected in a much more complex who classification of tumours of hematopoietic and lymphoid tissue. the term "primary cns lymphoma" is now restricted to primary diffuse large b-cell lymphoma confined to the cns (and/or to the eye) that occurs in immunoc ... | 2014 | 24806301 |
| epstein-barr virus-associated lymphoepithelioma-like cholangiocarcinoma: a rare variant of intrahepatic cholangiocarcinoma with favourable outcome. | lymphoepithelioma-like cholangiocarcinoma (lelcc) is a rare variant of intrahepatic cholangiocarcinoma (ihcc). only 16 cases have reported previously in the literature, and about 62.5% of these cases were associated with epstein-barr virus (ebv). | 2014 | 24804938 |
| comprehensive comparative and semiquantitative proteome of a very low number of native and matched epstein-barr-virus-transformed b lymphocytes infiltrating human melanoma. | melanoma, the deadliest form of skin cancer, is highly immunogenic and frequently infiltrated with immune cells including b cells. the role of tumor-infiltrating b cells (tibcs) in melanoma is as yet unresolved, possibly due to technical challenges in obtaining tibcs in sufficient quantity for extensive studies and due to the limited life span of b cells in vitro. a comprehensive workflow has thus been developed for successful isolation and proteomic analysis of a low number of tibcs from fresh, ... | 2014 | 24803318 |
| intravascular natural killer cell lymphoma mimicking mycosis fungoides: a case report and review of the literature. | intravascular lymphoma is a rare entity. most cases constitute a variant of extranodal diffuse large b-cell lymphoma, and only 10% of the published cases are of t-cell or histiocytic origin. even fewer cases of intravascular natural killer (nk) cell lymphoma have been reported. to date, only the intravascular lymphoma of b-cell linage is recognized as a distinct entity by the who classification. here, we report the clinical, morphological, immunohistochemical, and molecular findings of a 72-year ... | 2014 | 24803068 |
| pcr array analysis of gene expression profiles in chronic active epstein-barr virus infection. | to determine the host cellular gene expression profiles in chronic active epstein-barr virus infection (caebv), peripheral blood samples were obtained from three patients with caebv and investigated using a pcr array analysis that focused on t-cell/b-cell activation. we identified six genes with expression levels that were tenfold higher in caebv patients compared with those in healthy controls. these results were verified by quantitative reverse transcription-pcr. we identified four highly upre ... | 2014 | 24801498 |
| role of latent membrane protein 1 in chronic active epstein-barr virus infection-derived t/nk-cell proliferation. | epstein-barr virus (ebv) predominantly infects b cells and causes b-cell lymphomas, such as burkitt lymphoma and hodgkin lymphoma. however, it also infects other types of cells, including t and natural killer (nk) cells, and causes disorders, such as chronic active ebv infection (caebv) and t/nk-cell lymphoma. the caebv is a lymphoproliferative disease with poor prognosis, where ebv-positive t or nk cells grow rapidly, although the molecular mechanisms that cause the cell expansion still remain ... | 2014 | 24799376 |
| multiple sclerosis: the elevated antibody response to epstein-barr virus primarily targets, but is not confined to, the glycine-alanine repeat of epstein-barr nuclear antigen-1. | patients with multiple sclerosis (ms) have elevated antibodies against epstein-barr virus (ebv), but data on the epitope-resolved specificity of these antibodies are scarce. using a peptide microarray containing 1465 peptides representing 8 full-length ebv proteins, we identified higher (p<0.001) antibody reactivities to 39 ebv-peptides in ms patients (n=29) compared to healthy controls (n=22). seventeen of the 39 peptides were from ebna-1 and 13 located within the glycine-alanine repeat of ebna ... | 2014 | 24798244 |
| hemophagocytic lymphohistiocytosis associated with viral infections: diagnostic challenges and therapeutic dilemmas. | hemophagocytic lymphohistiocytosis is a frequently fatal clinicopathologic syndrome in which an uncontrolled and ineffective immune response leads to severe hyperinflammation. it may occur as either a familial disorder or a sporadic condition in association with a variety of triggers: infections, malignancies, autoimmune diseases, and acquired immune deficiencies. however, the most consistent association is with viral infections, especially epstein-barr virus. the main clinical features are feve ... | 2014 | 24796638 |
| the beneficial effect of plasmapheresis in mixed connective tissue disease with coexisting antiphospholipid syndrome. | the authors report a rare case of a female patient with mixed connective tissue disease (mctd) with coexisting antiphospholipid syndrome (aps). five years after the diagnosis of mctd high concentrations of anticardiolipin (anti-cl) and anti-β2-glycoprotein (anti-β2gpi) autoantibodies were present in the patient's serum without thrombotic events. epstein-barr virus (ebv) reactivation provoked aps, with the clinical manifestations of livedo reticularis, digital gangrene and leg ulcers. skin biopsy ... | 2014 | 24795068 |
| characteristics of epstein-barr viraemia in adult liver transplant patients: a retrospective cohort study. | therapeutic immunosuppression following solid organ transplantation increases the risk of epstein-barr (ebv) viraemia, which is implicated in post-transplant lymphoproliferative disease (ptld). we retrospectively analysed the incidence of ebv viraemia and clinical outcomes in 98 liver transplant recipients. patients underwent ebv dna monitoring by whole-blood pcr: ebv levels were correlated with clinical parameters and outcomes for a median of 249 days. 67% patients developed ebv viraemia (ebv d ... | 2014 | 24750406 |
| active cytomegalovirus infection is not a risk factor for epstein-barr virus dnaemia in the allogeneic stem cell transplantation setting. | 2014 | 24750291 | |
| acute retinal necrosis associated with epstein-barr virus: immunohistopathologic confirmation. | acute retinal necrosis (arn) is an infectious retinitis primarily caused by the herpesviruses. although the epstein-barr virus (ebv) has been implicated as a cause of arn, to our knowledge, there has been no histopathologic documentation. we report the clinical history and histopathologic confirmation that ebv can cause arn. | 2014 | 24743882 |
| serum zta antibody of epstein-barr virus exerts potential function in the diagnosis of nasopharyngeal cancer. | the diagnosis of nasopharyngeal cancer (npc) remains a clinical challenge. many studies have assessed the diagnostic potential of zta antibody of the epstein-barr virus (ebv) in npc patients but with controversial results. this study aims to summarize the overall diagnostic performance of ebv zta antibody in npc. based on a comprehensive search of the pubmed and embase, web of science, chinese national knowledge infrastructure (cnki), wanfang databases and china citation databases, we identified ... | 2014 | 24737587 |
| religious attendance and biological functioning: a multiple specification approach. | this study explores the role of religious attendance across a wide range of biological markers. | 2014 | 24733752 |
| immune escape of γ-herpesviruses from adaptive immunity. | epstein-barr virus (ebv) and kaposi's sarcoma-associated herpesvirus (kshv) are two γ-herpesviruses identified in humans and are strongly associated with the development of malignancies. murine γ-herpesvirus (mhv-68) is a naturally occurring rodent pathogen, representing a unique experimental model for dissecting γ-herpesvirus infection and the immune response. these γ-herpesviruses actively antagonize the innate and adaptive antiviral responses, thereby efficiently establishing latent or persis ... | 2014 | 24733560 |
| the epstein barr-encoded bart-6-3p microrna affects regulation of cell growth and immuno response in burkitt lymphoma. | burkitt lymphoma is an aggressive b-cell lymphoma presenting in three clinical forms: endemic, sporadic and immunodeficiency-associated. more than 90% of endemic burkitt lymphoma carry latent epstein-barr virus, whereas only 20% of sporadic burkitt lymphoma are associated with epstein-barr infection. although the epstein-barr virus is highly related with the endemic form, how and whether the virus participates in its pathogenesis remains to be fully elucidated. in particular, the virus may impai ... | 2014 | 24731550 |
| epitope distribution in ordered and disordered protein regions. part b - ordered regions and disordered binding sites are targets of t- and b-cell immunity. | intrinsically disordered proteins exist in highly flexible conformational states linked to different protein functions. in this work, we have presented evidence that hla class-i- and class-ii-binding t-cell epitopes, experimentally verified in several tumor-associated antigens and nuclear systemic autoantigens, are predominantly located in ordered protein regions or at disorder/order borderlines, defined by the majority of analyzed publicly available disorder predictors. we have also observed th ... | 2014 | 24726865 |
| il-27r-mediated regulation of il-17 controls the development of respiratory syncytial virus-associated pathogenesis. | il-27 is a heterodimeric cytokine composed of the subunits p28 and epstein-barr virus induced gene (ebi)-3 and is known for its effects on t-cell function and differentiation. il-27 signals through the widely expressed il-27 receptor (il-27r), composed of the ligand-specific il-27rα chain and gp130. engagement of the il-27r activates stat1 signaling, induces the expression of the type 1 helper t-cell (th1) cytokine, interferon γ, and suppresses the differentiation of th2 and th17 cells. this stu ... | 2014 | 24726498 |
| hypothesis: a role for ebv-induced molecular mimicry in parkinson's disease. | current concepts regarding the pathogenesis of parkinson's disease support a model whereby environmental factors conspire with a permissive genetic background to initiate the disease. the identity of the responsible environmental trigger has remained elusive. there is incontrovertible evidence that aggregation of the neuronal protein alpha-synuclein is central to disease pathogenesis. a novel hypothesis of parkinson's pathogenesis, articulated by braak and colleagues, implicates a pathogen actin ... | 2014 | 24726430 |
| metronomic adjuvant chemotherapy improves treatment outcome in nasopharyngeal carcinoma patients with postradiation persistently detectable plasma epstein-barr virus deoxyribonucleic acid. | to investigate the effects of adjuvant chemotherapy in nasopharyngeal carcinoma (npc) patients with persistently detectable plasma epstein-barr virus dna (pebv dna) after curative radiation therapy plus induction/concurrent chemotherapy. | 2014 | 24725686 |
| [extranodal nk/t-cell lymphoma]. | the prognosis of extranodal nk/t-cell lymphoma (enkl) used to be poor and this lymphoma was one of the most difficult lymphoma subtypes to treat. however, in recent years, novel treatment strategies have been applied, and the prognosis has greatly improved. simultaneous chemoradiotherapy is currently regarded as the standard for nasal enkl limited at most to neck lymph nodes. for advanced or relapsed enkl. l-asparaginase containing regimen such as smile or aspametdex is recommended. hematopoieti ... | 2014 | 24724414 |
| [pathological diagnosis of mature t/nk cell lymphoma]. | peripheral t-cell lymphoma (ptcl) and natural killer/t-cell lymphoma (nktcl) are rare and heterogeneous forms of non-hodgkin lymphoma (nhl) that, in general, are associated with a poor clinical outcome. in addition, many subtypes are present in the world health organization (who) classification of ptcl. to well classify and diagnose the ptcl, clinical, molecular, morphological and phenotypic data are necessary. for example, human t-cell leukemia virus type 1 (htlv-i) provirus is necessary for th ... | 2014 | 24724401 |