Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| application of circulating plasma/serum ebv dna in the clinical management of nasopharyngeal carcinoma. | elevated levels of circulating cell-free epstein-barr virus (ebv) dna have been detected in plasma and serum samples from nasopharyngeal cancer (npc) patients by quantitative real time pcr (qpcr) test. this qpcr test for circulating ebv dna was found to be useful in the clinical management of npc patients. for instance, ebv dna qpcr test has good sensitivity and specificity in the detection of npc at disease onset. increase of the viral dna load was found in npc patients at late stages of diseas ... | 2014 | 24440146 |
| primary anorectal hodgkin lymphoma: report of a case and review of the literature. | primary colorectal lymphomas are very rare. they are mostly b-cell non-hodgkin lymphomas. only 2 cases of anorectal hodgkin lymphoma have been described so far, both affecting hiv-infected males and showing epstein-barr virus infection. we report an unusual case of primary hodgkin lymphoma of the anorectal region in an hiv-negative, epstein-barr virus-infected patient and in the absence of inflammatory bowel disease. the importance of distinguishing hodgkin lymphoma from epstein-barr virus-induc ... | 2014 | 24440095 |
| indolent peripheral t-cell lymphoma involving the gastrointestinal tract. | we describe an unusual case of indolent peripheral t-cell lymphoma with multifocal involvement of the gastrointestinal tract. the patient, a 42-year-old asian man, has been followed up for more than 10 years without chemotherapy and multiple gastrointestinal biopsies showing similar findings. histologically, the neoplasm expanded into the lamina propria and/or focally extended into the submucosa and was composed of small- to medium-sized lymphocytes with slightly irregular nuclear contours and c ... | 2014 | 24439229 |
| clonal heterogeneity of thymic b cells from early-onset myasthenia gravis patients with antibodies against the acetylcholine receptor. | myasthenia gravis (mg) with antibodies against the acetylcholine receptor (achr-mg) is considered as a prototypic autoimmune disease. the thymus is important in the pathophysiology of the disease since thymus hyperplasia is a characteristic of early-onset achr-mg and patients often improve after thymectomy. we hypothesized that thymic b cell and antibody repertoires of achr-mg patients differ intrinsically from those of control individuals. using immortalization with epstein-barr virus and toll- ... | 2014 | 24439114 |
| epstein-barr virus-encoded rnas as a survival predictor in nasopharyngeal carcinoma. | epstein-barr virus (ebv) infection is one of the most important factors of nasopharyngeal carcinoma (npc) endemic areas. transcription of ebv-encoded non-polyadenylated rnas (ebers) are presented in most of npc tumors. exploring ebers as a prognostic marker for npc might further be informative about the biology and the progression of the disease. the aim of this study was to analyze the role of ebv latency in the clinical management of nasopharyngeal carcinoma (npc), by detecting ebers. | 2014 | 24438619 |
| epstein-barr virus-associated t/natural killer-cell lymphomas in the elderly: the first consensus meeting in kofu 2013. | from a clinicopathological conference on nine elderly patients with epstein-barr virus (ebv)-associated t/natural killer (nk)-cell lymphoma, we have addressed the patients' backgrounds, clinical manifestations, histopathological findings, cytogenesis, complications and prognoses. among these elderly patients (>65 years old), seven patients had extranodal nk/t-cell lymphoma, nasal type (enkl) with an nk-cell phenotype, and two patients had ebv(+) t-cell lymphomas or lymphoproliferative disorders ... | 2014 | 24438143 |
| epstein-barr virus-associated t/natural killer-cell lymphoproliferative disorders. | primary infection with epstein-barr virus (ebv) is usually asymptomatic and, in a normal host, ebv remains latent in b cells after primary infection for the remainder of life. uncommonly, ebv can infect t or natural killer (nk) cells in a person with a defect in innate immunity, and ebv infection can cause unique systemic lymphoproliferative diseases (lpd) of childhood. primary infection in young children can be complicated by hemophagocytic lymphohistiocytosis or fulminant systemic t-cell lpd o ... | 2014 | 24438142 |
| pattern analysis of epstein-barr virus viremia and its significance in the evaluation of organ transplant patients suspected of having posttransplant lymphoproliferative disorders. | to explore posttransplant lymphoproliferative disorder (ptld) cases associated with epstein-barr virus (ebv). | 2014 | 24436276 |
| targeting epstein-barr virus-associated lymphomas. | 2014 | 24493729 | |
| epstein-barr virus-specific adoptive immunotherapy for progressive multiple sclerosis. | defective control of epstein-barr virus (ebv) infection by cytotoxic cd8(+) t cells might predispose to multiple sclerosis (ms) by allowing ebv-infected autoreactive b cells to accumulate in the central nervous system. we have treated a patient with secondary progressive ms with in vitro-expanded autologous ebv-specific cd8(+) t cells directed against viral latent proteins. this adoptive immunotherapy had no adverse effects and the patient showed clinical improvement with reduced disease activit ... | 2014 | 24493474 |
| rash and elevated creatine kinase in a deployed soldier. | a 24-year-old active duty soldier was evacuated from afghanistan to the united states after persistent upper respiratory tract infection. his course was complicated by an exfoliative rash, diffuse muscle aches, and elevated creatine kinase following trimethoprim-sulfamethoxazole exposure that persisted despite withdrawal of the medication. dermatomyositis was strongly considered, but the patient had a negative muscle biopsy and had positive serologies for acute epstein-barr virus infection. we p ... | 2014 | 24491625 |
| [correlation between dna damage and eb virus infection in nasopharyngeal carcinoma]. | to explore the correlation between the expression of phosphorylated histone h2ax (γ-h2ax) and epstein-barr virus (ebv) infection in nasopharyngeal carcinoma (npc) specimens, and to investigate the role and mechanism of ebv-induced dna damage in npc tumorigenesis and development in vitro. | 2014 | 24491061 |
| integrated mrna and microrna transcriptome sequencing characterizes sequence variants and mrna-microrna regulatory network in nasopharyngeal carcinoma model systems. | nasopharyngeal carcinoma (npc) is a prevalent malignancy in southeast asia among the chinese population. aberrant regulation of transcripts has been implicated in many types of cancers including npc. herein, we characterized mrna and mirna transcriptomes by rna sequencing (rnaseq) of npc model systems. matched total mrna and small rna of undifferentiated epstein-barr virus (ebv)-positive npc xenograft x666 and its derived cell line c666, well-differentiated npc cell line hk1, and the immortalize ... | 2014 | 24490137 |
| immunoglobulin g subclass profile of anticitrullinated peptide antibodies specific for epstein barr virus-derived and histone-derived citrullinated peptides. | 2014 | 24488853 | |
| small molecule inhibition of epstein-barr virus nuclear antigen-1 dna binding activity interferes with replication and persistence of the viral genome. | the replication and persistence of extra chromosomal epstein-barr virus (ebv) episome in latently infected cells are primarily dependent on the binding of ebv-encoded nuclear antigen 1 (ebna1) to the cognate ebv orip element. in continuation of the previous study, herein we characterized ebna1 small molecule inhibitors (h20, h31) and their underlying inhibitory mechanisms. in silico docking analyses predicted that h20 fits into a pocket in the ebna1 dna binding domain (dbd). however, h20 did not ... | 2014 | 24486954 |
| trans-oral brush biopsies and quantitative pcr for ebv dna detection and screening of nasopharyngeal carcinoma. | to evaluate a newly developed noninvasive ambulatory, quantitative polymerase chain reaction (q-pcr) epstein-barr virus (ebv) dna detection and screening system (np screen™) for nasopharyngeal carcinoma (npc). | 2014 | 24486777 |
| transcriptional regulation and functional characterization of the oxysterol/ebi2 system in primary human macrophages. | oxysterols such as 7 alpha, 25-dihydroxycholesterol (7α,25-ohc) are natural ligands for the epstein-barr virus (ebv)-induced gene 2 (ebi2, aka gpr183), a g protein-coupled receptor (gpcr) highly expressed in immune cells and required for adaptive immune responses. activation of ebi2 by specific oxysterols leads to chemotaxis of b cells in lymphoid tissues. while the ligand gradient necessary for this critical process of the adaptive immune response is established by a stromal cells subset here w ... | 2014 | 24480442 |
| obstructive sleep apnea (osa): a complication of acute infectious mononucleosis infection in a child. | independently, obstructive sleep apnea (osa) and infectious mononucleosis are not uncommon in the pediatric population, but acute onset of osa, as a respiratory complication in the setting of acute ebv infection is extremely uncommon. previous reports of this clinical entity are sparse and from nearly two decades ago. urgent adenotonsillectomy was commonly advocated. this complication may be managed medically with systemic corticosteroids and non-invasive continuous positive airway pressure (cpa ... | 2014 | 24480119 |
| possible autoimmune hepatitis induced after chronic active epstein-barr virus infection. | chronic active epstein-barr virus infection (caebv) can be manifested in a variety of systemic conditions, including interstitial pneumonia, malignant lymphoma, and coronary aneurysm. sometimes it may be associated with hepatic failure, although the mechanism underlying caebv-related hepatotoxicity remains unclear. we encountered a case of autoimmune hepatitis (aih) associated with caebv. a 61-year-old male was referred to our hospital because of abnormal liver enzyme levels after initial diagno ... | 2014 | 26183510 |
| erratum: nasopharyngeal carcinoma in brunei darussalam: low incidence among the chinese and an evaluation of antibodies to epstein-barr virus antigens as biomarkers. | [this corrects the article on p. 371 in vol. 50, pmid: 19421680.]. | 2014 | 25964953 |
| anti-neutrophil cytoplasmic antibody-associated vasculitis associated with infectious mononucleosis due to primary epstein-barr virus infection: report of three cases. | although the aetiology of anti-neutrophil cytoplasmic antibody (anca)-associated vasculitis remains unclear, it is generally believed that environmental factors such as infections contribute to its development of anca-associated vasculitis. prior epstein-barr virus (ebv) infection is reported to be a trigger of systemic vasculitis. we herein report three cases of anca-associated vasculitis presenting with infectious mononucleosis due to primary ebv infection. the causal link between the two path ... | 2014 | 25859349 |
| association of inconclusive sera for human immunodeficiency virus infection with malaria and epstein-barr virus infection in central africa. | among 464 sera from adults in cameroon, 56 (12.1%) gave inconclusive hiv serology. all were negative for hiv-1 dna; 44.6% (n = 25) were significantly associated with plasmodium (42.8%) or epstein-barr virus (ebv) (17.8%) infections. in central africa, sera giving inconclusive results for hiv are frequently associated with malaria, ebv infection, or both. | 2014 | 24478507 |
| evaluation of plasma epstein-barr virus dna load to distinguish nasopharyngeal carcinoma patients from healthy high-risk populations in southern china. | the utility of circulating epstein-barr virus (ebv) dna as a tumor marker for nasopharyngeal carcinoma (npc) detection suggests that it might improve the diagnostic performance of anti-ebv antibody markers in npc screening. in this study, the authors evaluated whether circulating ebv dna load is capable of distinguishing npc patients from high-risk individuals who have positive anti-ebv antibodies. | 2014 | 24477877 |
| a de novo unclassified malignant spindle cell neoplasm of liver allograft. | spindle cell neoplasms are rarely reported in liver allografts; most are benign and associated with epstein-barr virus infection. we present a case of a malignant spindle cell neoplasm arising in a liver allograft. the patient underwent orthotopic liver transplant for cirrhosis secondary to nonalcoholic steatohepatitis. after 2 years, he presented with vague abdominal complaints. imaging studies revealed a 10-cm right hepatic lobe mass. the patient underwent right-sided hepatectomy. the tumor di ... | 2014 | 24476524 |
| epstein-barr virus-related post-transplant lymphoproliferative disorder in solid organ transplant recipients. | epstein-barr virus (ebv) contributes to the pathogenesis of post-transplant lymphoproliferative disease (ptld) in more than 70% of cases. ebv dnaemia surveillance has been reported to assist in the prevention and treatment of ptld in hematopoietic stem-cell transplantation (hsct) recipients. derived from experience in hsct and taking into account that pcr-based ebv monitoring techniques are currently available in most solid organ transplant (sot) centres, there is a great interest in ebv surveil ... | 2014 | 24475976 |
| murine gammaherpesvirus-68 orf38 encodes a tegument protein and is packaged into virions during secondary envelopment. | tegument is the unique structure of a herpesvirion which occupies the space between nucleocapsid and envelope. accumulating data have indicated that interactions among tegument proteins play a key role in virion morphogenesis. morphogenesis of gammaherpesviruses including kaposi's sarcoma-associated herpesvirus (kshv) and epstein-barr virus (ebv) is poorly understood due to the lack of efficient de novo lytic replication in cell culture. murine gammaherpesvirus-68 (mhv-68) is genetically related ... | 2014 | 24474202 |
| epstein-barr virus and hodgkin lymphoma in jordan. | this study aims to examine the possible association of epstein-barr virus (ebv) in classical hodgkin lymphoma (chl) and to shed light on the epidemiology of hodgkin lymphoma (hl) in jordan. | 2014 | 24472289 |
| hydroa vacciniforme-like cutaneous t-cell lymphoma. | a 14-year-old chinese girl had a 6-year history of recurrent lesions on her head, face, and limbs. epstein-barr virus (ebv)-igm was positive. histopathological findings revealed focal lymphocyte invasion in subcutaneous panniculus adiposus, mainly surrounding the blood vessels. immunohistochemistry showed cd3+, cd4+, cd5+, cd8+, tia-1+, grb+, cd56-, and l26-. in situ hybridization staining for ebv-encoded small nonpolyadenylated rna (eber)-1 was positive. the patient showed significant improveme ... | 2014 | 24470671 |
| primary brain lymphomas after kidney transplantation: an under-recognized problem? | primary central nervous system post-transplant lymphoproliferative disease (cns ptld) is a serious complication after solid organ transplantation that has not received much attention so far. however, it could become a more frequent problem with the introduction of new biological agents. | 2014 | 24469958 |
| epigenetic regulation of ebv persistence and oncogenesis. | epigenetic mechanisms play a fundamental role in generating diverse and heritable patterns of viral and cellular gene expression. epstein-barr virus (ebv) can adopt a variety of gene expression programs that are necessary for long-term viral persistence and latency in multiple host-cell types and conditions. the latent viral genomes assemble into chromatin structures with different histone and dna modifications patterns that control viral gene expression. variations in nucleosome organization an ... | 2014 | 24468737 |
| pathogenesis and treatment of extranodal natural killer/t-cell lymphoma. | extranodal natural killer (nk)/t-cell lymphoma, nasal type (enkl) is one of the uncommon subtypes of malignant lymphoma, and predominantly occurs in the nasal or paranasal areas and less frequently in the skin. previously, its prognosis was poor due to the expression of p-glycoprotein, which actively exports several anticancer agents outside the lymphoma cells. however, in recent years, novel therapeutic approaches such as simultaneous chemoradiotherapy or l-asparaginase-based regimens including ... | 2014 | 24468315 |
| [hemophagocytic syndrome associated with epstein-barr virus. presentation of a case and treatment in the resuscitation unit]. | we report the case of a 17 year old male patient, who was admitted to the resuscitation unit with the diagnosis of hemophagocytic syndrome, associated with infection by epstein-barr virus with unfavorable outcome. hemophagocytic syndrome is a pathological immune activation syndrome due to the production/uncontrolled modulation of some cytokines. its clinical signs and symptoms, defined by consensus criteria hlh-2004, are not pathognomonic, and often appear sequentially, thus suspicion should be ... | 2014 | 24468010 |
| presence of epstein-barr virus-infected b lymphocytes with thyrotropin receptor antibodies on their surface in graves' disease patients and in healthy individuals. | graves' disease is an autoimmune hyperthyroidism caused by thyrotropin receptor antibodies (trabs). because epstein-barr virus (ebv) persists in b cells and is occasionally reactivated, we hypothesized that ebv contributes to trabs production in graves' disease patients by stimulating the trabs-producing b cells. in order for ebv to stimulate antibody-producing cells, ebv must be present in those cells but that have not yet been observed. we examined whether ebv-infected (ebv(+)) b cells with tr ... | 2014 | 24467196 |
| ebv load in whole blood correlates with lmp2 gene expression after pediatric heart transplantation or allogeneic hematopoietic stem cell transplantation. | epstein-barr virus (ebv) is associated with posttransplant lymphoproliferative disease (ptld), and ebv load measurement is an important tool to monitor transplant patients. although ebv dna quantification has high sensitivity to identify patients at risk for ptld, it lacks specificity. we examined whether ebv gene expression in peripheral b cells can increase specificity or correlates with ebv load. | 2014 | 24389909 |
| diagnosis of epstein-barr virus infection in clinical serum samples by an spr biosensor assay. | label-free affinity biosensors offer a promising platform for the development of a new generation of medical diagnostic technologies. nevertheless, when such sensors are used in complex biological media, adsorption of non-targeted medium components prevents the specific detection of the analyte. in this work, we introduce for the first time a biosensor assay based on surface plasmon resonance (spr) capable of diagnosing different stages of epstein-barr virus (ebv) infections in clinical serum sa ... | 2014 | 24389391 |
| duplex realtime pcr method for epstein-barr virus and human dna quantification: its application for post-transplant lymphoproliferative disorders detection. | the quantification of circulating epstein-barr virus (ebv) dna is used to monitor transplant patients as an early marker of post-transplant lymphoproliferative disorders (ptld). so far no standardized methodology exists for such determination. | 2014 | 24389276 |
| systematic review and meta-analysis of the sero-epidemiological association between epstein-barr virus and systemic lupus erythematosus. | infection with epstein-barr virus (ebv) has been suggested to contribute to the pathogenesis of systemic lupus erythematosus (sle). we sought to determine whether prior infection with the virus occurs more frequently in patients with sle compared to matched controls. | 2014 | 24387619 |
| epstein-barr virus-related post-transplant lymphoproliferative disorder occurring after bone marrow transplantation for aplastic anemia in down's syndrome. | it is well established that down's syndrome exhibits a predisposition to development of leukemia, however, association between aplastic anemia and down's syndrome is exceptional. herein, we describe a case of aplastic anemia occurring in down's syndrome following post-transplant lymphoproliferative disorder (ptld) after bone marrow transplantation (bmt). a 27-year-old japanese male with down's syndrome presented with a headache. laboratory tests revealed severe pancytopenia, and bone marrow biop ... | 2014 | 24427369 |
| primary gingival diffuse large b-cell lymphoma: a case report and a review of the literature. | the patient was a 73-year-old male who came to our hospital with a chief complaint of pain and swelling of the left side of his jaw. computed tomography revealed a mass in his left gingiva but no bone destruction. no lesions were observed at any other sites, and an incisional biopsy was performed on the gingival mass on the left side. histologically, the mass was a diffuse large b-cell lymphoma (dlbcl), and it was cd20-positive, and cd5-negative, cd10-negative, surface immunoglobulin-negative, a ... | 2014 | 24427366 |
| a probable identical epstein-barr virus clone-positive composite lymphoma with aggressive natural killer-cell leukemia and cytotoxic t-cell lymphoma. | the patient was a 52-year old woman with a history of mosquito-bite hypersensitivity since childhood. in july 2011, she developed pyrexia, headaches, and nausea, and epstein-barr virus (ebv)-positive aggressive natural killer leukemia (ankl) was diagnosed on the basis of both a peripheral blood and bone marrow examination. an inguinal lymph node biopsy, on the other hand, revealed ebv-positive cytotoxic t-cell lymphoma plus the presence of a small number of ebv-positive ankl cells, and a diagnos ... | 2014 | 24427365 |
| not like a wrecking ball: ebv fine-tunes myc lymphomagenesis. | in this issue of blood, fish et al uncover how epstein-barr virus (ebv) enhances myc-driven b-cell lymphoma by crossing ebv em-ebv latent membrane protein 2a (lmp2a) transgenic mice with immunoglobulin-l (igl)-myc transgenic mice. | 2014 | 24458272 |
| regulation of the latent-lytic switch in epstein-barr virus. | epstein-barr virus (ebv) infection contributes to the development of several different types of human malignancy, including burkitt lymphoma, hodgkin lymphoma, and nasopharyngeal carcinoma. as a herpesvirus, ebv can establish latent or lytic infection in cells. ebv-positive tumors are composed almost exclusively of cells with latent ebv infection. strategies for inducing the lytic form of ebv infection in tumor cells are being investigated as a potential therapy for ebv-positive tumors. in this ... | 2014 | 24457012 |
| resolution of methotrexate-induced epstein-barr virus-associated mucocutaneous ulcer. | 2014 | 24456137 | |
| deficient ebv-specific b- and t-cell response in patients with chronic fatigue syndrome. | epstein-barr virus (ebv) has long been discussed as a possible cause or trigger of chronic fatigue syndrome (cfs). in a subset of patients the disease starts with infectious mononucleosis and both enhanced and diminished ebv-specific antibody titers have been reported. in this study, we comprehensively analyzed the ebv-specific memory b- and t-cell response in patients with cfs. while we observed no difference in viral capsid antigen (vca)-igg antibodies, ebv nuclear antigen (ebna)-igg titers we ... | 2014 | 24454857 |
| rituximab single agent in age-related epstein-barr virus associated b cell disorder complicated by autoimmune anemia and pure red cell aplasia. | 2014 | 24452366 | |
| acute acalculous cholecystitis associated with severe ebv hepatitis in an immunocompetent child. | acute acalculous cholecystitis (aac) is an inflammation of the gallbladder in the absence of demonstrated stones, which is rarely seen in paediatric population. the diagnosis is accomplished mainly through abdominal ultrasonography in the appropriate but usually non-specific clinical picture. complicated cases need surgical intervention; the medical management is mainly constituted by supportive and antibiotic therapy, as most aac are observed in the setting of systemic bacterial or parasitic in ... | 2014 | 24419637 |
| a-ring modified betulinic acid derivatives as potent cancer preventive agents. | ten new 3,4-seco betulinic acid (ba) derivatives were designed and synthesized. among them, compounds 7-15 exhibited enhanced chemopreventive ability in an in vitro short-term 12-o-tetradecanoylphorbol-13-acetate (tpa) induced epstein-barr virus early antigen (ebv-ea) activation assay in raji cells. specifically, analogs with a free c-28 carboxylic acid, including 7, 8, 11, and 13, inhibited ebv-ea activation significantly. the most potent compound 8 displayed 100% inhibition at 1×10(3) mol rati ... | 2014 | 24411124 |
| ebv-positive mtx-diffuse large b cell lymphoma in a rheumatoid arthritis patient. | methotrexate (mtx)-associated lymphoproliferative disorders have received much attention from rheumatologists, and early diagnosis is very important for reducing mortality. there are several reports of radiologic findings in patients with pulmonary malignant lymphoma, mainly consisting of masses, nodules, and lymphadenopathy. computed tomography has rarely detected necrosis in the masses. in this article, we report a case of mtx-associated epstein-barr virus-positive diffuse large b-cell lymphom ... | 2014 | 24408079 |
| classification of aids-related lymphoma cases between 1987 and 2012 in japan based on the who classification of lymphomas, fourth edition. | the introduction of combined antiretroviral therapy (art) has reduced the mortality of patients with human immunodeficiency virus-1 infection worldwide. however, malignant lymphoma is a severe and frequent complication seen in patients with acquired immunodeficiency syndrome (aids). the diagnostic criteria for some categories of aids-related lymphoma were revised in the world health organization international classification of lymphoma, fourth edition. the purpose of this study was to assess the ... | 2014 | 24407967 |
| increased levels of neurotrophins in the cerebrospinal fluid of children with epstein-barr virus meningoencephalitis. | the aim of this study was to evaluate the expression of nerve growth factor (ngf) and brain-derived neurotrophic factor (bdnf) in the cerebrospinal fluid (csf) of children with epstein-barr virus (ebv)-induced meningoencephalitis (me) in order to establish a possible correlation with laboratory findings and neurological manifestations. | 2014 | 24406738 |
| epstein-barr virus-driven bone marrow aplasia and plasmacytosis mimicking a plasma cell neoplasm. | 2014 | 24405048 | |
| unconventional sequence requirement for viral late gene core promoters of murine gammaherpesvirus 68. | infection with the human gammaherpesviruses, epstein-barr virus (ebv) and kaposi's sarcoma-associated herpesvirus (kshv), is associated with several cancers. during lytic replication of herpesviruses, viral genes are expressed in an ordered cascade. however, the mechanism by which late gene expression is regulated has not been well characterized in gammaherpesviruses. in this study, we have investigated the cis element that mediates late gene expression during de novo lytic infection with murine ... | 2014 | 24403583 |
| excess body mass is associated with t cell differentiation indicative of immune ageing in children. | obesity has been associated with accelerated biological ageing and immunosenescence. as the prevalence of childhood obesity is increasing, we wanted to determine if associations between obesity and immunosenescence would manifest in children. we studied 123 mexican american adolescents aged 10-14 (mean 12·3 ± 0·7) years, with body weights ranging from 30·1 to 115·2 kg (mean 52·5 ± 14·5 kg). blood samples were obtained to determine proportions of naive, central memory (cm), effector memory (em), ... | 2014 | 24401077 |
| controlled epstein-barr virus reactivation after allogeneic transplantation is associated with improved survival. | epstein-barr virus reactivation (ebv-r) frequently occurs in patients having allogeneic hematopoietic stem cell transplantation (hsct). we evaluated the impact of controlled ebv-r on survival of 190 patients (114m/76f, median age: 51 yr, range 18-69), having hsct for hematological malignancies (105 acute leukemias and myelodysplasias, 71 lymphoproliferative disorders, 14 others). overall survival (os) and progression-free survival (pfs) were compared between patients with and without ebv-r. of 1 ... | 2014 | 24400833 |
| primary central nervous system epstein-barr virus-positive diffuse large b-cell lymphoma of the elderly: a clinicopathologic study of five cases. | we report five cases of primary central nervous system (cns) epstein-barr virus (ebv)-positive lymphoma of the elderly. this represented an incidence of 4 % of primary cns diffuse large b-cell lymphoma (dlbcl) after ebv screening in 134 cases. all five patients were 65 years or older with no previous history of congenital or iatrogenic immune deficiencies. the histologic morphology of all the cases was dlbcl, with variable amounts of necrosis. the cell of origin (coo) as determined by the hans a ... | 2014 | 24399201 |
| tumour angiogenesis in epstein-barr virus-associated post-transplant smooth muscle tumours. | epstein-barr virus (ebv)-associated post-transplant smooth muscle tumours (ptsmt), are rare complications following organ/stem cell transplantation. despite the mainly benign behaviour of ptsmt, alternative therapies are needed for those patients with progressive tumours. in tumours not approachable by surgery or reduction of immunosuppression, the angiogenic microenvironment might be a potential target of therapy, an approach that is well utilised in other soft tissue neoplasms. in a previous s ... | 2014 | 24398114 |
| development of lymphomas containing epstein-barr virus after therapy with hyper-cvad regimen. | 2014 | 24393621 | |
| murine gammaherpesvirus m2 protein induction of irf4 via the nfat pathway leads to il-10 expression in b cells. | reactivation of the gammaherpesviruses epstein-barr virus (ebv), kaposi's sarcoma-associated herpesvirus (kshv) and murine gammaherpesvirus 68 (mhv68) from latently infected b cells has been linked to plasma cell differentiation. we have previously shown that the mhv68 m2 protein is important for virus reactivation from b cells and, when expressed alone in primary murine b cells, can drive b cell differentiation towards a pre-plasma cell phenotype. in addition, expression of m2 in primary murine ... | 2014 | 24391506 |
| epstein-barr virus-positive diffuse large b-cell lymphoma of the elderly complicated by the onset of acute myeloid leukemia. | we herein describe the case of a 62-year-old woman who presented with anemia and an 8-month history of weight loss. bone marrow aspiration showed increased myeloblasts. the histopathology findings of biopsy specimens of the right cervical lymph node and intestinal mass indicated b-lymphoproliferative disorder (b-lpd) with hodgkin lymphoma-like morphologic features and polymorphous diffuse large b-cell lymphoma (dlbcl), respectively. in addition, both types of lymphoma cells were positive for eps ... | 2014 | 24390529 |
| t cells modulate epstein-barr virus latency phenotypes during infection of humanized mice. | human b cells, the main target of epstein-barr virus (ebv), can display several types of latent viral protein expression, denoted 0, i, iia, iib, or iii. of these, only type iii expression induces proliferation of cells in vitro. these latency types are present at specific stages of infection and are also characteristic of different tumor types, but their generation is not fully understood. in this study, we analyzed the role of t cells in the regulation of ebv viral latency by using humanized n ... | 2014 | 24390326 |
| autoverification in a core clinical chemistry laboratory at an academic medical center. | autoverification is a process of using computer-based rules to verify clinical laboratory test results without manual intervention. to date, there is little published data on the use of autoverification over the course of years in a clinical laboratory. we describe the evolution and application of autoverification in an academic medical center clinical chemistry core laboratory. | 2014 | 24843824 |
| deficiency of cd8+ effector memory t cells is an early and persistent feature of multiple sclerosis. | patients with multiple sclerosis (ms) have a deficiency of circulating cd8+ t cells, which might impair control of epstein-barr virus (ebv) and predispose to ms by allowing ebv-infected autoreactive b cells to accumulate in the central nervous system. based on the expression of cd45ra and cd62l, cd4+ t cells and cd8+ t cells can be subdivided into four subsets with distinct homing and functional properties, namely: naïve, central memory, effector memory (em) and effector memory re-expressing cd4 ... | 2014 | 24842963 |
| antibodies to epstein-barr virus and mri disease activity in multiple sclerosis. | previous reports indicate an association between epstein-barr virus (ebv) antibody levels and multiple sclerosis (ms) disease activity, but the results have been conflicting. | 2014 | 24842958 |
| asymptomatic post-transplant lymphoproliferative disorder diagnosed at one year protocol renal allograft biopsy. | post-transplant lymphoproliferative disorder (ptld) is a neoplastic complication with a potentially fatal outcome that develops as a consequence of immunosuppression, and is mainly associated with epstein-barr virus (ebv) infection. a 70-year-old woman underwent a live unrelated, abo-incompatible renal transplant for end-stage renal disease. one year after transplantation, protocol biopsy revealed pathological changes indicative of the histological subtype of 'early lesions of ptld' according to ... | 2014 | 24842822 |
| tobacco smoking increases immune activation and impairs t-cell function in hiv infected patients on antiretrovirals: a cross-sectional pilot study. | the influence of tobacco smoking on the immune system of hiv infected individuals is largely unknown. we investigated the impact of tobacco smoking on immune activation, microbial translocation, immune exhaustion and t-cell function in hiv infected individuals. | 2014 | 24842313 |
| primary cutaneous follicle center lymphoma with diffuse cd30 expression: a report of 4 cases of a rare variant. | cd30 is expressed in aggressive and epstein-barr virus-associated forms of b-cell non-hodgkin lymphomas, but is rarely expressed by the majority of tumor cells in primary cutaneous b-cell lymphomas (cbcls). the expression of cd30 in cbcls may be at risk for misinterpretation as an unequivocal indicator of a highly aggressive form of the disease. | 2014 | 24836545 |
| synergistic action of compounds isolated from the hexane extract of ardisia crispa root against tumour-promoting effect, in vitro. | an isomeric mixture of α,β-amyrin (triterpene) and 2-methoxy-6-undecyl-1,4-benzoquinone (quinone) isolated from the ardisia crispa root hexane (acrh) extract was reported to possess anti-inflammatory properties in vivo. considering the close association between inflammation and cancer, on top of the lack of antitumour study on those compounds, this study aimed to determine the potential of both compounds against tumour promotion in vitro, either as single agent or in combination. triterpene and ... | 2014 | 24836304 |
| smarcb1(ini1)-deficient sinonasal basaloid carcinoma: a novel member of the expanding family of smarcb1-deficient neoplasms. | poorly differentiated sinonasal carcinomas are a heterogenous group of aggressive neoplasms that encompasses squamous cell carcinoma including basaloid variant, lymphoepithelial carcinoma, sinonasal undifferentiated carcinoma, and neuroendocrine-type small cell carcinoma. we herein describe 3 cases of a hitherto unreported variant combining features of basaloid carcinoma with variable intermingled rhabdoid cells. patients were 2 women (aged 28 and 35) and a man (52 y) who presented with sinonasa ... | 2014 | 24832165 |
| clinicopathologic comparison of plasmablastic lymphoma in hiv-positive, immunocompetent, and posttransplant patients: single-center series of 25 cases and meta-analysis of 277 reported cases. | plasmablastic lymphoma (pbl) is a rare b-cell non-hodgkin lymphoma often associated with epstein-barr virus (ebv) infection. to gain insight in this aggressive lymphoma subtype, the clinicopathologic characteristics of 25 unpublished single-center pbls (2 in acquired immunodeficiency syndrome patients, 11 in immunocompetent individuals [ic-pbl], 12 in transplant recipients [pt-pbl]) and of 277 reported pbls were summarized. in the reported series, pbl patients were predominantly male (77%) with ... | 2014 | 24832164 |
| [severe lactic acidosis revealing hematologic malignancy]. | a 75-year-old woman is hospitalised for sepsis. the diagnosis of cholecystitis is made and an antibiotic therapy is debuted. the clinical worsening leads to realise an urgent cholecystectomy. a sepsis like shock persisted. the antibiotherapy was changed and a second abdominal look made. a severe lactic acidosis persisted since the cholecystectomy despite a continuous hemofiltration. the diagnosis of type b lactic acidosis secondary to malignancy was suspected. an osteomedullar biopsy revelled b- ... | 2014 | 24927632 |
| management of advanced nk/t-cell lymphoma. | nk/t-cell lymphomas are aggressive malignancies, and the outlook is poor when conventional anthracycline-containing regimens designed for b-cell lymphomas are used. with the advent of l-asparaginase-containing regimens, treatment outcome has significantly improved. l-asparaginase-containing regimens are now considered the standard in the management of nk/t-cell lymphomas. in advanced diseases, however, outcome remains unsatisfactory, with durable remission achieved in only about 50% of cases. st ... | 2014 | 24924658 |
| reduced-intensity conditioning hematopoietic cell transplantation is an effective treatment for patients with slam-associated protein deficiency/x-linked lymphoproliferative disease type 1. | x-linked lymphoproliferative disease type 1 (xlp1) is a rare immune deficiency caused by mutations in sh2d1a. allogeneic hematopoietic cell transplantation (hct) is often performed because of the morbidity and mortality associated with xlp1. there is limited experience using reduced-intensity conditioning (ric) regimens for these patients. here we report our 8-year single-center experience. sixteen consecutive patients diagnosed with xlp1 underwent allogeneic hct between 2006 and 2013 after a ri ... | 2014 | 24923536 |
| variable expression of b-cell transcription factors in reactive immunoblastic proliferations: a potential mimic of classical hodgkin lymphoma. | reactive immunoblastic proliferations can histologically mimic classical hodgkin lymphoma (chl), and show diffuse cd30 expression in large cells. the lack of expression of cd15 in a subset of chl further complicates their separation from immunoblastic proliferations. loss of expression of b-cell transcription factors is frequently exploited in making a diagnosis of chl; however, the staining patterns of b-cell transcription factors in immunoblastic proliferations have not been extensively studie ... | 2014 | 24921642 |
| expression of latent membrane proteins in epstein‑barr virus-transformed lymphocytes in vitro. | infection with epstein-barr virus (ebv) induces activation and proliferation of b lymphocytes. detection of latent membrane protein (lmp)-1 is used to identify the proliferative ability of b cells. however, changes in the expression levels of the three lmps during ebv-induced b lymphocyte transformation, have not yet been reported. in the present study, the expression levels of lmp-1, lmp-2a and lmp-2b were compared between ebv-transformed b lymphocytes and paired normal lymphocytes. seven lymph ... | 2014 | 24919846 |
| epstein-barr virus in the central nervous system and cervical lymph node of a patient with primary progressive multiple sclerosis. | 2014 | 24918642 | |
| inhibition of mtorc1 inhibits lytic replication of epstein-barr virus in a cell-type specific manner. | epstein-barr virus is a human herpesvirus that infects a majority of the human population. primary infection of epstein-barr virus (ebv) causes the syndrome infectious mononucleosis. this virus is also associated with several cancers, including burkitt's lymphoma, post-transplant lymphoproliferative disorder and nasopharyngeal carcinoma. as all herpesvirus family members, ebv initially replicates lytically to produce abundant virus particles, then enters a latent state to remain within the host ... | 2014 | 24917448 |
| epstein-barr virus serology and pcr: conflicting results in an immunocompetent host. a case report and review of literature. | we present the case of a 27-year-old immunocompetent man who progressively developed a generalized lymphadenopathy and b symptoms. results of epstein-barr virus (ebv) serology were suggestive for a past infection, but the ebv viral load in whole blood was high. also, core needle biopsy of the largest lymph node showed an image which could fit an ebv-driven reactive lymphoproliferation. despite the absence of an immune disorder, all medical evidence points to an ebv-driven lymphoproliferative pro ... | 2014 | 24916751 |
| epstein-barr virus (ebv) infection in chinese children: a retrospective study of age-specific prevalence. | epstein-barr virus (ebv) is a globally prevalent herpesvirus associated with infectious mononucleosis and many malignancies. the survey on ebv prevalence appears to be important to study ebv-related diseases and determine when to administer prophylactic vaccine. the purpose of this retrospective study was to collect baseline information about the prevalence of ebv infection in chinese children. | 2014 | 24914816 |
| epigenetic dysregulation in epstein-barr virus-associated gastric carcinoma: disease and treatments. | epstein-barr virus (ebv)-associated gastric carcinoma (ebvagc) comprises nearly 10% of gastric carcinoma cases worldwide. recently, it was recognised to have unique clinicopathologic characteristics, including male predominance, lower rates of lymph node involvement, and better prognosis. ebvagc is further characterised by abnormal hypermethylation of tumour suppressor gene promoter regions, causing down-regulation of their expression. in the present review, we critically discuss the role of ebv ... | 2014 | 24914366 |
| the placental specific gene, plac1, is induced by the epstein-barr virus and is expressed in human tumor cells. | the epstein-barr virus (ebv) is a causal agent in a number of malignancies in humans including hematopoietic tumors and non-hematopoietic tumors. burkitt's lymphoma cell lines containing the epstein-barr virus have been shown to form tumors in nude mice while clonal derivatives of such cell lines in which the viral genome has been lost do not (jid 177: 1194-1201, 1998; jv 72: 9150-9156, 1998; jv 68: 6069-6073, 1994). the re-introduction of ebv into these ebv negative bls reconstitutes the tumor ... | 2014 | 24912876 |
| connective tissue diseases: epstein-barr virus in sjögren's syndrome salivary glands drives local autoimmunity. | 2014 | 24934188 | |
| a possible familial lymphoproliferative disorder in two male siblings of children with recurrent wheezing and lung infections since infancy. | malignancies that result in wheezing in infants are very uncommon. given its rarity in children, the diagnosis is challenging, and in the absence of a high index of suspicion, delayed diagnosis is not uncommon. here we report two male siblings of children who presented with recurrent wheezing and recurrent lung infections since infancy. both children showed no laboratory evidence of immunodeficiency. lymphocytic interstitial pneumonia or hypersensitivity pneumonitis was histologically suspected ... | 2014 | 24934116 |
| lymphomatoid granulomatosis involving the central nervous system: a case report and review of the literature. | lymphomatoid granulomatosis (lyg) is a rare tumor with unknown etiology. specific etiological factors for lyg are also unknown, although previous data indicates that lyg is an epstein-barr virus-associated b-cell proliferation associated with an exuberant t-cell reaction. according to the 2008 who classification, lyg is characterized by b-cell proliferation of b-lymphoma cells. generally, treatment options for lyg are similar to those for diffuse large b-cell lymphoma. unfortunately, lyg is a ch ... | 2014 | 24932245 |
| burkitt lymphoma: epidemiological features and survival in a south african centre. | the epidemiology of burkitt lymphoma (bl) shows that the endemic type is mainly confined to equatorial africa and has a very close association with the epstein-barr virus (ebv), while the sporadic variant shows only a 20% association with ebv and is seen mainly in europe and north america. an immunodeficent form of bl has been described more recently. this study aimed to describe the epidemiological characteristics and survival of children presenting with bl to tygerberg hospital, cape town, in ... | 2014 | 24932211 |
| pityriasis rubra pilaris (prp) with preceding epstein-barr virus infection: a new type prp with non-hiv virus infection? | 2014 | 24931263 | |
| improved elongation factor-1 alpha-based vectors for stable high-level expression of heterologous proteins in chinese hamster ovary cells. | establishing highly productive clonal cell lines with constant productivity over 2-3 months of continuous culture remains a tedious task requiring the screening of tens of thousands of clonal colonies. in addition, long-term cultivation of many candidate lines derived in the absence of drug selection pressure is necessary. expression vectors based on the elongation factor-1 alpha (eef1a) gene and the dihydrofolate reductase (dhfr) selection marker (with separate promoters) can be used to obtain ... | 2014 | 24929670 |
| ebi3 is pivotal for the initiation of experimental autoimmune uveitis. | murine experimental autoimmune uveitis (eau) is a model for human autoimmune uveitis, whose pathogenesis is caused by both th1 and th17 cell responses. epstein-barr virus-induced gene 3 (ebi3) is a component of the heterodimeric cytokines: interleukin (il)-27 and il-35. although il-27 was shown to initiate th1 cell development, it is also recognized as a negative regulator of fully activated cd4+ t cells, including th17 cells. recently, il-35 also has also been reported to play immunosuppressive ... | 2014 | 24929202 |
| hematopoietic cell transplantation for plasmablastic lymphoma: a review. | plasmablastic lymphoma (pbl) is recognized by the world health organization as a very aggressive subtype of non-hodgkin lymphoma. it was initially described in the setting of human immunodeficiency virus (hiv) infection, but it has since been identified in immunocompetent patients, as well. pbl is characterized by cd20 negativity and is associated with epstein-barr virus infection. the outcome with available therapy is poor, with median survival of less than 1 year. multiple adverse prognostic f ... | 2014 | 24946718 |
| race/ethnic and socioeconomic differences in stress and immune function in the national longitudinal study of adolescent health. | stress and immune function may be important mediators of the strong association between social factors and health over the life course, but previous studies have lacked the data to fully explore these links in a population-based sample. this study utilizes data from waves i-iv of the u.s. national longitudinal study of adolescent health (add health) to test the associations of race/ethnicity and socioeconomic status (ses) with levels of perceived stress and exposure to stressful life events (sle ... | 2014 | 24946263 |
| attachment anxiety is related to epstein-barr virus latency. | attachment theory provides a framework for understanding individual differences in chronic interpersonal stress. attachment anxiety, a type of relationship insecurity characterized by worry about rejection and abandonment, is a chronic interpersonal stressor. stress impacts cellular immunity, including herpesvirus reactivation. we investigated whether attachment anxiety was related to the expression of a latent herpesvirus, epstein-barr virus (ebv), when individuals were being tested for breast ... | 2014 | 24945717 |
| the first endogenous herpesvirus, identified in the tarsier genome, and novel sequences from primate rhadinoviruses and lymphocryptoviruses. | herpesviridae is a diverse family of large and complex pathogens whose genomes are extremely difficult to sequence. this is particularly true for clinical samples, and if the virus, host, or both genomes are being sequenced for the first time. although herpesviruses are known to occasionally integrate in host genomes, and can also be inherited in a mendelian fashion, they are notably absent from the genomic fossil record comprised of endogenous viral elements (eves). here, we combine paleovirolo ... | 2014 | 24945689 |
| tumor microenvironment and rig-i signaling molecules in epstein barr virus-positive and -negative classical hodgkin lymphoma of the elderly. | classical hodgkin lymphoma (chl) is a b-cell neoplasm characterized by hodgkin and reed-sternberg (hrs) cells. its prevalence exhibits a bimodal pattern of peaking in young adults and the elderly. there is an association with epstein-barr virus (ebv) infection in about 50% of cases of chl of the elderly, and the outcome of these patients is unfavorable. it is not well known how the latent infection of ebv is involved in the pathophysiology of chl of the elderly. to address this issue, we examine ... | 2014 | 24942949 |
| a de novo monoclonal immunoglobulin deposition disease in a kidney transplant recipient: a case report. | myeloma following kidney transplantation is a rare entity. it can be divided into two groups: relapse of a previous myeloma and de novo myeloma. some of these myelomas can be complicated by a monoclonal immunoglobulin deposition disease, which is even less common. less than ten cases of monoclonal immunoglobulin deposition disease after renal graft have been reported in the literature. the treatment of these patients is not well codified. | 2014 | 24942882 |
| latent membrane protein 1 and the b lymphocyte-a complex relationship. | the epstein barr virus (ebv)-encoded latent membrane protein 1 (lmp1) exerts numerous impacts on the functions of b lymphocytes, the cell type in which ebv establishes long-term latent infections. lmp1 expression has been implicated in making important contributions to a variety of human malignancies, as well as to autoimmune diseases. ebv also infects other types of immune cells, as well as nasopharyngeal epithelium, and evidence suggests that lmp1 functions may differ among cell types. in this ... | 2014 | 24941072 |
| clinical analysis of 102 cases of epstein-barr virus infections in chinese children. | the purpose of this study is to investigate the clinical manifestations and disease severity, to evaluate the recent trend of clinical manifestations and differences in the clinical and laboratory findings of ebv-associated im (infectious mononucleosis) according to the age of children. we retrospectively collected cases on hospitalized patients a majority of 7 years old with characteristic symptoms of im and serologically diagnosed ebv-associated im at shaanxi provincial peoples university hosp ... | 2014 | 24940855 |
| hits-clip and par-clip advance viral mirna targetome analysis. | mirnas regulate gene expression by binding predominantly to the 3' untranslated region (utr) of target transcripts to prevent their translation and/or induce target degradation. in addition to the more than 1200 human mirnas, human dna tumor viruses such as kaposi's sarcoma-associated herpesvirus (kshv) and epstein-barr virus (ebv) encode mirnas. target predictions indicate that each mirna targets hundreds of transcripts, many of which are regulated by multiple mirnas. thus, target identificatio ... | 2014 | 24940765 |
| the expression of renal epstein-barr virus markers in patients with lupus nephritis. | the aim of this study was to investigate the role of renal epstein-barr virus (ebv) infection in the pathogenesis of lupus nephritis (ln). a total of 58 renal tissue samples from patients with ln, seven normal renal tissue samples from patients with non-glomerular hematuria and 37 renal tissue samples from patients with minimal change nephropathy were collected. the expression of ebv-latent membrane protein-1 (ebv-lmp1) and ebv-encoded rna 1 (eber-1) in the renal tissue was examined by immunohis ... | 2014 | 24940399 |
| continuity and innovation in the data collection protocols of the second wave of the national social life, health, and aging project. | the second wave (w2) of the national social life, health, and aging project (nshap), a nationally representative, longitudinal survey of older adults now between the ages of 62 and 90, conducted approximately 3,400 interviews. selected coresidential romantic partners as well as w1 panel nonrespondents were selected for w2. data collection included in-person questionnaires, up to 15 biomeasures, and a post-interview questionnaire. | 2014 | 24939998 |
| chronic active epstein-barr virus infection complicated with multiple artery aneurysms. | 2014 | 24939943 | |
| hiv-related nk/t-cell lymphoma in the brain relapsed during intensive chemotherapy but regressed after chemotherapy discontinuation: the importance of maintaining cellular immunity. | this study reports a case of human immunodeficiency virus (hiv)-related natural killer/t-cell lymphoma with an unexpected clinical course. the lymphoma cells were positive for epstein-barr virus and the primary nodal lesions regressed after chemotherapy and combined antiretroviral therapy (c-art); however, brain metastasis progressed along with a reduction in the cd8+ t-cell count. chemotherapy was discontinued and the patient was treated with c-art alone, resulting in regression of the brain le ... | 2014 | 24938379 |