Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| investigation of bk virus, epstein-barr virus and human papillomavirus sequences in postoperative thyroid gland specimens. | although recent evidence has implicated viruses in the regulation of epithelial-to-mesenchymal transition and tumor progression, little is known regarding viral infections in thyroid malignancies. thus the aim of this study was to detect sequences of 3 potentially oncogenic viruses - bk virus (bkv), epstein-barr virus (ebv) and human papillomavirus (hpv) - in a series of postoperative thyroid gland specimens. | 2015 | 25262702 |
| ebi2 regulates intracellular signaling and migration in human astrocyte. | the g protein-coupled receptor ebi2 (epstein-barr virus-induced gene 2) is activated by 7α, 25-dihydroxycholesterol (7α25hc) and plays a role in t cell-dependant antibody response and b cell migration. aberrant ebi2 signaling is implicated in a range of autoimmune disorders however its role in the cns remains unknown. here we characterize the functional role of ebi2 in glia cells using primary human astrocytes and ebi2 knockout animals. we find human and mouse astrocytes express ebi2 and the enz ... | 2015 | 25297897 |
| generalized pustular psoriasis associated with epstein-barr virus. | generalized pustular psoriasis (gpp) is a rare and severe variant of psoriasis. we report a case of a 79-year-old woman who presented with generalized pustular psoriasis and significant epstein-barr virus (ebv) viraemia. serial measurements of ebv dna showed a correlation with the deterioration in her clinical condition. we speculate that ebv reactivation triggered the development of gpp, and propose that further investigation is required into the association between ebv and gpp. | 2015 | 25267463 |
| a pilot trial of quantitative epstein-barr virus polymerase chain reaction in patients undergoing treatment for their malignancy: potential use of epstein-barr virus polymerase chain reaction in multiple cancer types. | 2015 | 25219594 | |
| interleukin 23 produced by myeloid dendritic cells contributes to t-cell dysfunction in hiv type 1 infection by inducing socs1 expression. | the mechanism of myeloid dendritic cell (mdc)-mediated impaired t-cell function was investigated during human immunodeficiency virus type 1 (hiv-1) infection. hiv or gp120 were found to inhibit lipopolysaccharide-induced mdc maturation and cause defects in allogeneic t-cell proliferation, interleukin 2 and interferon γ (ifn-γ) production, and phosphorylated stat1 expression. gp120-treated mdcs downregulated autologous t-cell proliferation and ifn-γ production against a peptide pool consisting of ... | 2015 | 25234720 |
| survival rates and prognostic factors of epstein-barr virus-associated hydroa vacciniforme and hypersensitivity to mosquito bites. | epstein-barr virus (ebv)-associated t/natural-killer lymphoproliferative disorders form a group of diseases that includes classical and systemic hydroa vacciniforme (hv) and hypersensitivity to mosquito bites (hmb). patients with systemic hv (shv) and hmb often have a poor prognosis, although little is known about the prognostic factors. | 2015 | 25234411 |
| prevention of posttransplant lymphoproliferative disorder in pediatric patients with a liver transplant. | this study sought to evaluate in pediatric liver transplant recipients the effects of hybrid antiviral therapy on the rate of posttransplant lymphoproliferative disorder. | 2015 | 25232740 |
| (68)ga-dota (0)-tyr (3)-octreotide positron emission tomography in nasopharyngeal carcinoma. | pet/ct with (68)ga-labelled [dota(0),tyr(3)]-octreotide ((68)ga-dota-toc pet/ct) is a routinely used imaging modality for neuroendocrine tumours expressing somatostatin receptors (sstr). recent studies have shown sstr expression in head and neck squamous cell carcinoma, albeit lower than in highly differentiated neuroendocrine tumours. we sought to determine whether nasopharyngeal carcinoma (npc) positive for epstein-barr virus (ebv), a rare subtype of head and neck cancer, shows increased (68)g ... | 2015 | 25227762 |
| identification of low-dose responsive metabolites in x-irradiated human b lymphoblastoid cells and fibroblasts. | ionizing radiation (ir) induces cellular stress responses, such as signal transduction, gene expression, protein modification, and metabolite change that affect cellular behavior. we analyzed x-irradiated human epstein-barr virus-transformed b lymphoblastoid cells and normal fibroblasts to search for metabolites that would be suitable ir-responsive markers by liquid chromotography-mass spectrometry (lc-ms). mass spectra, as analyzed with principal component analysis, showed that the proportion o ... | 2015 | 25227127 |
| circulating epstein-barr virus micrornas mir-bart7 and mir-bart13 as biomarkers for nasopharyngeal carcinoma diagnosis and treatment. | more than 75% of nasopharyngeal carcinoma (npc) patients have already developed local or regional spread at diagnosis, which hampers effective treatment and results in a poor prognosis. it is essential to characterize more sensitive and specific biomarkers for screening of high risk individuals and assessment of npc treatment effectiveness. npc is an epstein-barr virus (ebv) associated tumor in which only a few viral proteins but more than 20 bamhi a rightward transcripts (bart) micrornas are de ... | 2015 | 25213622 |
| targeting epstein-barr virus infection as an intervention against multiple sclerosis. | we here review contemporary data on genetic and environmental risk factors, particularly epstein-barr virus infection, for multiple sclerosis. there is an important immunogenetic etiological factor for multiple sclerosis. however, a general assumption is that immune defense genes are activated by the environment, basically by infections. we contend that the relationship between infectious mononucleosis and multiple sclerosis cannot be completely explained by genetics and inverse causality. epste ... | 2015 | 25208981 |
| primary central nervous system extranodal nk/t cell lymphoma, nasal type, with antecedent hemophagocytic syndrome in a child. | primary central nervous system (cns) extranodal natural killer (nk)/t-cell lymphoma, nasal type (nktcl), is an exceedingly uncommon entity. here, we present a case of cns nktcl that manifested initially as hemophagocytic syndrome 4 months earlier in a 13-year-old girl. histological examination revealed the cerebellum mass was composed of large-sized and atypical tumor cells, with an angiocentric and angiodestructive growth pattern and prominent necrosis. the tumor cells exhibited marked pleomorp ... | 2015 | 25207703 |
| clinical utility gene card for: x-linked immunodeficiency with magnesium defect, epstein-barr virus infection, and neoplasia (xmen). | 2015 | 25205404 | |
| acquired ige-mediated food allergy after liver transplantation in children. | in recent years, the number of studies regarding newly-diagnosed food allergies after liver transplantation has been increasing. in this study, we aimed to investigate the frequency, aetiology, risk factors, and severity of ige-mediated food allergies after liver transplantation in children. | 2015 | 25201761 |
| epigenetic markers for noninvasive early detection of nasopharyngeal carcinoma by methylation-sensitive high resolution melting. | nasopharyngeal carcinoma (npc) is a human malignancy that is closely associated with epstein-barr virus (ebv). early diagnosis of npc will greatly improve the overall survival. however, current ebv dna marker detection still lacks the predictive value to perform well in high-risk populations for early detection of npc. since aberrant promoter hypermethylation of tumor suppressor genes (tsgs) is widely considered to be an important epigenetic change in early carcinogenesis, this study identified ... | 2015 | 25196065 |
| analysis of prognostic factors and comparison of prognostic scores in peripheral t cell lymphoma, not otherwise specified: a single-institution study of 105 chinese patients. | peripheral t cell lymphoma, not otherwise specified (ptcl-nos) is a heterogeneous subtype of non-hodgkin's lymphoma. this study aims to better define the prognostic factors and compare the predictive value of the prognostic scores in chinese patients with ptcl-nos. one hundred and five patients diagnosed as ptcl-nos from our institution were retrospectively studied and grouped according to four previously described prognostic scores [international prognostic index (ipi), prognostic index for ptc ... | 2015 | 25193354 |
| rituximab, dexamethasone, cytarabine, and cisplatin as effective platinum-based salvage chemotherapy for periportal posttransplant lymphoproliferative disorder after an orthotopic liver transplant. | posttransplant lymphoproliferative disorder is a group of heterogenous disorders that occur after solid-organ transplant. the overall incidence is between 1% and 20%. in orthotopic liver transplant recipients, the reported incidence ranges from 2% to 10%, while the incidence is greater in children (9.7%-11%) and lesser in adults (1.7%-3%). the following treatment options are considered for patients with posttransplant lymphoproliferative disorder: reduction of immunosuppression, single-agent rit ... | 2015 | 25184436 |
| synchronous posttransplant lymphoproliferative disorder and inflammatory myofibroblastic tumor of the lung in a 2-year-old liver transplanted boy: a case report. | inflammatory myofibroblastic tumor is a rare benign lesion found mostly in children and young adults. it originates from the lung, abdominopelvic region, and retroperitoneum. the tumor is composed of myofibroblasts and inflammatory cell infiltration in the tissue. the cause and pathogenesis of this tumor are not completely understood. epstein-barr virus has been held responsible in some reported cases of inflammatory myofibroblastic tumors. another tumor (which is known to be related to the epst ... | 2015 | 25184247 |
| primary cutaneous nk/t-cell lymphoma, nasal type and cd56-positive peripheral t-cell lymphoma: a cellular lineage and clinicopathologic study of 60 patients from asia. | primary cutaneous, extranodal natural killer/t-cell lymphoma, nasal type (pc-enktl), is a rare epstein-barr virus (ebv)-associated neoplasm with poorly defined clinicopathologic features. we performed a multinational retrospective study of pc-enktl and cd56-positive ebv-negative peripheral t-cell lymphoma (pc-cd56+ptcl) in asia in an attempt to elucidate their clinicopathologic features. using immunohistochemistry for t-cell receptors (tcrs), in situ hybridization for ebv, and tcr gene rearrange ... | 2015 | 25188863 |
| epstein-barr virus-encoded ebna1 and zebra: targets for therapeutic strategies against ebv-carrying cancers. | the ebv-encoded ebna1 was first discovered 40 years ago, approximately 10 years after the presence of ebv had been demonstrated in burkitt's lymphoma cells. it took another 10 years before the functions of ebna1 in maintaining the viral genome were revealed, and it has since been shown to be an essential viral factor expressed in all ebv-carrying cells. apart from serving to maintain the viral episome and to control viral replication and gene expression, ebna1 also harbours a cis-acting mechanis ... | 2015 | 25186125 |
| association of epstein-barr virus infection with oral squamous cell carcinoma in a case-control study. | besides the well-known risk factors, epstein-barr virus (ebv) might play a significant role in oral squamous cell carcinoma (oscc). to explore the role of ebv in oscc, the prevalence of ebv infection in oral exfoliated cells of oscc cases and controls in northeastern thailand was investigated, and the association of ebv in tumor lesion cells was further confirmed. | 2015 | 25169715 |
| ebv-negative cutaneous lymphomatoid granulomatosis with concomitant ebv-positive pulmonary involvement: a potential diagnostic and prognostic pitfall. | lymphomatoid granulomatosis (lyg) is a rare, t-cell-rich epstein-barr virus (ebv)-positive b-cell lymphoproliferative disorder. although lyg presents most often with lung involvement, up to half of affected individuals have concomitant cutaneous lyg. ebv-encoded rna (eber) is detected in the majority of pulmonary lesions but is often negative in skin lesions. herein, we describe a case of concomitant ebv-positive pulmonary and ebv-negative cutaneous lyg in a 70-year-old woman. histologically, bo ... | 2015 | 25148107 |
| hydroa vacciniforme-like lymphoma with primarily periorbital swelling: 7 cases of an atypical clinical manifestation of this rare cutaneous t-cell lymphoma. | hydroa vacciniforme-like lymphoma (hvl) is a rare cutaneous t-cell lymphoma that is usually seen in children of hispanic or asian origin. association between chronic latent epstein-barr virus infection in both hydroa vacciniforme (hv) and hvl has been demonstrated and has recently been categorized by the world health organization as one of the epstein barr virus-positive lymphoproliferative disorders of childhood. patients with hvl present with a cutaneous rash characterized by edema, blisters, ... | 2015 | 25162933 |
| epstein-barr virus-associated lymphoepithelioma-like gastric carcinoma located on gastric high body: two case reports. | lymphoepithelioma-like gastric carcinoma (lelgc) is a rare neoplasm of the stomach with an incidence of 1-4% of all gastric cancers. it is characterized by the presence of a lymphoid stroma with cells arranged primarily in micro alveolar, thin trabecular, and primitive tubular patterns or isolated cells. it is one of the histological patterns observed in patients with epstein - barr virus (ebv)-associated gastric carcinoma (ebvagc). in situ hybridization was usually used to confirm the presence ... | 2015 | 25118747 |
| hydroa vacciniforme-like lymphoma: a case report from india. | we report a 14-year-old indian boy who presented with a history of weight loss, fever, facial edema, and a relapsing papulovesicular eruption on the face and limbs for 1 year. histopathology of the skin showed dense lymphoid infiltrate from dermis to subcutaneous fat. immunohistochemistry of this lymphoid infiltrate was cd3, cd8, cd56, cd57, granzyme b, tia, and epstein barr virus lmp1. the histopathology and immunohistochemistry were consistent with the diagnosis of hydroa vacciniforme-like t-c ... | 2015 | 25072366 |
| induction treatment with smile and consolidation with autologous stem cell transplantation for newly diagnosed stage iv extranodal natural killer/t-cell lymphoma patients. | the aim of this study was to investigate the impact of the induction treatment with smile (dexamethasone, methotrexate, ifosfamide, l-asparaginase, and etoposide) chemotherapy and consolidation with upfront autologous stem cell transplantation (asct) on clinical outcomes of patients with stage iv extranodal natural killer/t-cell lymphoma (enktl). we analyzed the treatment response to smile and toxicity, and explored the feasibility of upfront asct in 27 patients with stage iv enktl out of patien ... | 2015 | 25082384 |
| aid expression in peripheral blood of children living in a malaria holoendemic region is associated with changes in b cell subsets and epstein-barr virus. | the development of endemic burkitt's lymphoma (ebl) is closely associated with epstein-barr virus (ebv) infection and holoendemic malaria infections. the role of ebv in the development of malignancy has been studied in depth, but there is still little known about the mechanisms by which malaria affects burkitt's lymphomagenesis. activation induced cytidine deaminase (aid) expression is necessary for the introduction of c-myc translocations that are characteristic of bl, but a link between aid an ... | 2015 | 25099163 |
| association between human papilloma virus/epstein-barr virus coinfection and oral carcinogenesis. | the recent epidemic of head and neck squamous cell carcinomas associated with human papilloma virus (hpv) has not addressed its association with lymphoid tissue in the oropharynx or the potential role of epstein-barr virus (ebv)/hpv coinfection. | 2015 | 25040496 |
| functional analysis and molecular characterization of spontaneously outgrown human lymphoblastoid cell lines. | in vitro, the infection of human b-cells with the lymphotropic gammaherpesvirus epstein-barr virus (ebv) induces formation of permanently growing lymphoblastoid cell lines (lcl). in a spontaneously outgrown lcl (cell line csiii), we detected nucleotide sequence variations of the ebv nuclear antigen 1 (ebna1) rna that was different from the reference sequence of ebna1 in the prototypic ebv strain b95-8. in the present study, we molecularly and functionally characterized this virus isolate in comp ... | 2014 | 25037273 |
| investigation of epstein-barr virus and parvovirus b19 dna in allogeneic stem cell transplant patients. | we aimed to investigate posttransplant epstein-barr virus (ebv) and parvovirus b19 dna in allogeneic stem cell transplant patients between 2009 and 2010. | 2014 | 25035673 |
| epstein-barr virus (ebv)-encoded dutpase and chronic restraint induce impaired learning and memory and sickness responses. | most adult humans have been infected with epstein-barr virus (ebv) and carry the latent virus. the ebv genome codes for several proteins that form an early antigen complex important for viral replication; one of these proteins is deoxyuridine triphosphate nucleotidohydrolase (dutpase). the ebv-encoded dutpase can induce sickness responses in mice. because stress can increase latent virus reactivation, we hypothesized that chronic restraint would exacerbate sickness behaviors elicited by ebv-enco ... | 2014 | 25034413 |
| critical review of topical management of oral hairy leukoplakia. | oral hairy leukoplakia (ohl) is a disease associated with epstein-barr virus and human immunodeficiency virus infections. ohl is usually an asymptomatic lesion, but in some cases treatment is recommended to reestablish the normal characteristics of the tongue, to eliminate pathogenic microorganisms, to improve patient comfort and for cosmetic reasons. proposed treatments for this condition include surgery, systemic antiviral treatment and topical management. topical treatment is an inexpensive a ... | 2014 | 25032199 |
| concurrent alterations of rage, reck, and mmp9 protein expression are relevant to epstein-barr virus infection, metastasis, and survival in nasopharyngeal carcinoma. | this study aimed to concurrently investigate the expressions of receptor for advanced glycation end products (rage), reversion inducing cysteine-rich protein with kazal motifs (reck) and matrix metalloproteinase 9 (mmp9) in nasopharyngeal carcinoma (npc) and their correlations with clinicopathological properties. using immunohistochemistry, we found that reck expression was downregulated in npc tissues compared with chronic nasopharyngitis (cnt) tissues, while rage and mmp9 expressions were upre ... | 2014 | 25031745 |
| epstein-barr virus ebna1 protein regulates viral latency through effects on let-7 microrna and dicer. | the ebna1 protein of epstein-barr virus (ebv) plays multiple roles in ebv latent infection, including altering cellular pathways relevant for cancer. here we used microrna (mirna) cloning coupled with high-throughput sequencing to identify the effects of ebna1 on cellular mirnas in two nasopharyngeal carcinoma cell lines. ebna1 affected a small percentage of cellular mirnas in both cell lines, in particular, upregulating multiple let-7 family mirnas, including let-7a. the effects of ebna1 on let ... | 2014 | 25031339 |
| mir-31 is consistently inactivated in ebv-associated nasopharyngeal carcinoma and contributes to its tumorigenesis. | as a distinctive type of head and neck cancers, nasopharyngeal carcinoma (npc) is genesis from the clonal epstein-barr virus (ebv)-infected nasopharyngeal epithelial cells accumulated with multiple genetic lesions. among the recurrent genetic alterations defined, loss of 9p21.3 is the most frequent early event in the tumorigenesis of ebv-associated npc. in addition to the reported cdkn2a/p16, herein, we elucidated the role of a mirna, mir-31 within this 9p21.3 region as npc-associated tumor supp ... | 2014 | 25098679 |
| study of epstein-barr virus expression in burkitt's lymphoma by polymerase chain reaction and in situ hybridization: a study in iran. | the association of epstein-barr virus (ebv) with burkitt's lymphoma (bl) is variable in different geographic regions. in developing countries, the association of ebv with bl is regarded to be of an endemic-type in equatorial africa (> 95%) and sporadic-type in the developed countries (15-30%). the purpose of this study is to assess the frequency of ebv infection in bl, in iran. the study also aims to compare ribonucleic acid (rna) in situ hybridization (rish), the standard diagnostic method, wit ... | 2014 | 25097650 |
| epstein-barr virus nuclear antigen 3a protein regulates cdkn2b transcription via interaction with miz-1. | the epstein-barr virus (ebv) nuclear antigen 3 family of protein is critical for the ebv-induced primary b-cell growth transformation process. using a yeast two-hybrid screen we identified 22 novel cellular partners of the ebna3s. most importantly, among the newly identified partners, five are known to play direct and important roles in transcriptional regulation. of these, the myc-interacting zinc finger protein-1 (miz-1) is a transcription factor initially characterized as a binding partner of ... | 2014 | 25092922 |
| [uveitis in multiple sclerosis : overview and perspectives]. | the association of uveitis and multiple sclerosis (ms) is less well known than the association between optic neuritis and ms even though ms patients suffer ten times more often from uveitis than the normal population. in this group of patients, intermediate uveitis presenting with periphlebitis and "snowbanks" or "snowballs", as well as granulomatous anterior uveitis play an important role. simultaneous occurrence of ms and uveitis could be due to the fact that both neural and ocular tissues hav ... | 2014 | 25092024 |
| multiplex pcr/mass spectrometry screening of biological carcinogenic agents in human mammary tumors. | while many studies have suggested a possible link between breast cancer pathogenesis and infection by viruses, the role of viruses in breast carcinogenesis remains controversial. | 2014 | 25088618 |
| mir-190 is upregulated in epstein-barr virus type i latency and modulates cellular mrnas involved in cell survival and viral reactivation. | epstein-barr virus (ebv) is a prevalent human pathogen infecting over 90% of the population. much of the success of the virus is attributed to its ability to maintain latency. the detailed mechanisms underlying the establishment and maintenance of ebv latency remain poorly understood. a microrna profiling study revealed differential expression of many cellular mirnas between types i and iii latency cells, suggesting cellular mirnas may play roles in regulating ebv latency. mir-190 is the most di ... | 2014 | 25086243 |
| [primary central nervous system post-transplant lymphoproliferative disorders]. | the post-transplant lymphoproliferative disorders (ptld) are a heterogeneous disease entity of lymphoid and plasmacytic proliferations that can occur after solid organ and bone marrow/stem cell transplantation. ptld sometimes involves the central nervous system (cns), but primary occurrence in central nervous system (pcns-ptld) is rare. the epstein-barr virus (ebv) plays a causative role, and up to 90% of the tumors are associated with this virus. diagnosing pcns-ptld is often challenging based ... | 2014 | 25082316 |
| epstein-barr virus-associated post-transplant lymphoproliferative disorder of plasma cell type following allogeneic haemopoietic stem cell transplant treated with rituximab. | 2014 | 25081050 | |
| a mutation in x-linked inhibitor of apoptosis (g466x) leads to memory inflation of epstein-barr virus-specific t cells. | mutations in the x-linked inhibitor of apoptosis (xiap) gene have been associated with xlp-like disease, including recurrent epstein-barr virus (ebv)-related haemophagocytic lymphohystiocytosis (hlh), but the immunopathogenic bases of ebv-related disease in xiap deficiency is unknown. we present the first analysis of ebv-specific t cell responses in functional xiap deficiency. in a family of patients with a novel mutation in xiap (g466x) leading to a late-truncated protein and varying clinical f ... | 2014 | 25079909 |
| comprehensive molecular characterization of gastric adenocarcinoma. | gastric cancer is a leading cause of cancer deaths, but analysis of its molecular and clinical characteristics has been complicated by histological and aetiological heterogeneity. here we describe a comprehensive molecular evaluation of 295 primary gastric adenocarcinomas as part of the cancer genome atlas (tcga) project. we propose a molecular classification dividing gastric cancer into four subtypes: tumours positive for epstein-barr virus, which display recurrent pik3ca mutations, extreme dna ... | 2014 | 25079317 |
| commutability of the epstein-barr virus who international standard across two quantitative pcr methods. | the commutability of international reference standards is critical for ensuring quantitative agreement across different viral load assays. here, we demonstrate the commutability of the epstein-barr virus (ebv) who international standard for the bamhi-w and artus ebv assays. | 2014 | 25078918 |
| murine gammaherpesvirus 68 reactivation from b cells requires irf4 but not xbp-1. | gammaherpesviruses display tropism for b cells and, like all known herpesviruses, exhibit distinct lytic and latent life cycles. one well-established observation among members of the gammaherpesvirus family is the link between viral reactivation from latently infected b cells and plasma cell differentiation. importantly, a number of studies have identified a potential role for a creb/atf family member, x-box binding protein 1 (xbp-1), in trans-activating the immediate early bzlf-1 or brlf1/gene ... | 2014 | 25078688 |
| sarcoidosis and purified protein derivative reactivity. | the possible association between (tuberculous and nontuberculous) mycobacterial infections and sarcoidosis is still a matter of dispute. using diagnostic tests for specific t-cell responses, this association can be investigated in an innovative manner. | 2014 | 25078642 |
| characterization of ebv-related lymphoproliferative lesions arising in donor lymphocytes of transplanted human tumor tissues in the nog mouse. | human tumor tissue line models established in the severely immunodeficient nod.cg-prkdc(scid) il2rg(tm1sug)/jic (nod/shi-scid, il-2rγ(null) or nog) mouse are important tools for oncology research. during the establishment process, a lymphoproliferative lesion (lpl) that replaces the original tumor cells in the site of transplantation occurs. in the present study, we studied the impact of the lpl on the establishment process and the characteristics of the lesion, investigated the systemic distrib ... | 2014 | 25077758 |
| prolonged febrile illness and fever of unknown origin in adults. | fever of unknown origin has been described as a febrile illness (temperature of 101°f [38.3°c] or higher) for three weeks or longer without an etiology despite a one-week inpatient evaluation. a more recent qualitative definition requires only a reasonable diagnostic evaluation. although there are more than 200 diseases in the differential diagnosis, most cases in adults are limited to several dozen possible causes. fever of unknown origin is more often an atypical presentation of a common disea ... | 2014 | 25077578 |
| splenic inflammatory pseudotumor-like follicular dendritic cell tumor. | inflammatory pseudotumor of the spleen with expression of follicular dendritic cell markers is an extremely rare lesion with only a few cases reported previously. the present study reports on an inflammatory pseudotumor of the spleen 10 × 8 × 7 cm in size that was incidentally found in a 61-year-old man and increased gradually in size during a period of 3 months. abdominal ultrasonography revealed a well-circumscribed splenic mass, and abdominal computed tomography confirmed the presence of a we ... | 2014 | 25076893 |
| transformation of small b-cell lymphoma into large cell cd30⁺, cd4⁺, epstein-barr virus-negative lymphoma. | we report here 2 separate cases in which patients with known low-grade b-cell lymphomas presented with transformed lesions that were cd30⁺, cd4⁺, epstein-barr virus negative, and negative or focally weak for a wide range of b-cell, t-cell, and histiocytic/dendritic cell markers. in each case the transformed lymphoma possessed an identical pattern of immunoglobulin heavy chain and/or bcl2 rearrangement to the corresponding original low-grade b-cell lymphoma, confirming their identity as transform ... | 2014 | 25076300 |
| interleukin-6 and interleukin-10 gene promoter polymorphisms and risk of endemic burkitt lymphoma. | overexpression of interleukin-6 (il-6) and il-10 in endemic burkitt lymphoma (ebl) may facilitate tumorigenesis by providing a permissive cytokine milieu. promoter polymorphisms influence interindividual differences in cytokine production. we hypothesized that children genetically predisposed for elevated cytokine levels may be more susceptible to ebl. using case-control samples from western kenya consisting of 117 ebl cases and 88 ethnically matched healthy controls, we tested for the associati ... | 2014 | 25071000 |
| fingerprints of epstein-barr virus in nasopharyngeal carcinoma. | 2014 | 25070800 | |
| lactoferrin suppresses the epstein-barr virus-induced inflammatory response by interfering with pattern recognition of tlr2 and tlr9. | epstein-barr virus (ebv) infection contributes to tumorigenesis of various human malignancies including nasopharyngeal carcinoma (npc). ebv triggers innate immune and inflammatory responses partly through toll-like receptor (tlr) signaling. lactoferrin (lf), with its anti-inflammatory properties, is an important component of the innate immune system. we previously reported that lf protects human b lymphocytes from ebv infection by its ability to bind to the ebv receptor cd21, but whether lf can ... | 2014 | 25068657 |
| establishment and operation of a good manufacturing practice-compliant allogeneic epstein-barr virus (ebv)-specific cytotoxic cell bank for the treatment of ebv-associated lymphoproliferative disease. | epstein-barr virus (ebv) is associated with several malignancies, including post-transplant lymphoproliferative disorder (ptld). conventional treatments for ptld are often successful, but risk organ rejection and cause significant side effects. ebv-specific cytotoxic t lymphocytes (ctls) generated in vitro from peripheral blood lymphocytes provide an alternative treatment modality with few side effects, but autologous ctls are difficult to use in clinical practice. here we report the establishme ... | 2014 | 25066775 |
| successful treatment of systemic and central nervous system post-transplant lymphoproliferative disorder without the use of high-dose methotrexate or radiation. | post-transplant lymphoproliferative disorder (ptld) describes a spectrum of conditions with highest incidence in the first year post-solid organ transplant in pediatric patients. central nervous system (cns) involvement with ptld carries high mortality risk with no consensus on optimal therapeutic regimen. we present the case of a 7-year old heart transplant patient diagnosed with widespread monomorphic, cd20+, epstein-barr virus-positive ptld, including cns involvement. in addition to immunosup ... | 2014 | 25066638 |
| quantitative pcr assays reveal high prevalence of lymphocryptovirus as well as lytic phase gene expression in peripheral blood cells of cynomolgus macaques. | lymphocryptoviruses such as epstein-barr virus (ebv) are important pathogens in both human and non-human primates, particularly during immunosuppression. immunomodulatory molecules that may suppress antiviral immunity are commonly tested in the cynomolgus macaque. to enable the study of lymphocryptovirus (lcv) in this non-clinical model, pcr-based assays were developed to measure lcv viral load, as well as transcripts for the lytic phase lcv gene, balf-2. results from studies employing these ass ... | 2014 | 25064358 |
| genome-wide dna methylation as an epigenetic consequence of epstein-barr virus infection of immortalized keratinocytes. | the oral cavity is a persistent reservoir for epstein-barr virus (ebv) with lifelong infection of resident epithelial and b cells. infection of these cell types results in distinct ebv gene expression patterns regulated by epigenetic modifications involving dna methylation and chromatin structure. regulation of ebv gene expression relies on viral manipulation of the host epigenetic machinery that may result in long-lasting host epigenetic reprogramming. to identify epigenetic events following eb ... | 2014 | 25056883 |
| acute unilateral cerebellitis, epstein-barr virus, and hiv. | 2014 | 25056020 | |
| decreased interleukin 35 and cd4+ebi3+ t cells in patients with active systemic lupus erythematosus. | interleukin 35 (il-35) is likely to contribute to the development of autoimmune diseases, as the epstein-barr virus-induced gene protein 3 (ebi3) is the specificity subunit of il-35. nevertheless, until recently, no studies have evaluated its role in systemic lupus erythematosus (sle) in humans. the objective of this study was to investigate the serum il-35 level and the percentage of cd4ebi3 t cells in the peripheral blood of patients with sle and explore the roles of double-positive t cells an ... | 2014 | 25054737 |
| [analysis of clinical and laboratory features of 217 pediatric hemophagocytic lymphohistiocytosis]. | to investigate the incidence, clinical symptoms, signs and laboratory features of childhood hemophagocytic lymphohistiocytosis (hlh) in china. | 2014 | 25052607 |
| [cell analogs of viral proteins]. | horizontal transfer of genes between viruses and their hosts played an important role in the evolution of various eukaryotes including contemporary mammals as well as the pathogens themselves. elements of viruses of various types can be found in the genome of animals. endogenous retroviral elements composing up to 8% of human genome length not only determine its high flexibility and rapid adaptation potential. many of virus genes such as fv1, lv1, lv2 being analogues of capsid and other proteins ... | 2014 | 25051706 |
| epstein-barr virus effect on frequency of functionally distinct t cell subsets in children with infectious mononucleosis. | epstein-barr virus is a common human pathogen which infects the great majority of population worldwide. a striking proliferation of cd8⁺ t cells is an immune response to ebv invasion of b lymphocytes during infectious mononucleosis. the aim of the study was to analyze frequencies of cd28⁺cd95⁻, cd28⁺cd95⁺, cd28⁻cd95⁺ t cell subsets putative naïve (t(n)), central (t(cm)) and effector memory (t(em)) t cells in children with infectious mononucleosis. | 2014 | 25051418 |
| the impact of plasma epstein-barr virus dna and fibrinogen on nasopharyngeal carcinoma prognosis: an observational study. | the impact of combining plasma fibrinogen levels with epstein-barr virus dna (ebv dna) levels on the prognosis for patients with nasopharyngeal carcinoma (npc) was evaluated. | 2014 | 25051405 |
| tonsillitis. | the definition of severe recurrent throat infections is arbitrary, but recent criteria have defined severe tonsillitis as: five or more episodes of true tonsillitis a year; symptoms for at least 1 year; and episodes that are disabling and prevent normal functioning. diagnosis of acute tonsillitis is clinical, and it can be difficult to distinguish viral from bacterial infections. rapid antigen testing has a very low sensitivity in the diagnosis of bacterial tonsillitis, but more accurate tests t ... | 2014 | 25051184 |
| large granules in the peripheral blood smear and bone marrow aspirate of a 3-year-old male with lymphadenopathy and fever. | a 3-year-old male with oculocutaneous albinism presented with lymphadenopathy and fever. serological testing revealed epstein-barr virus (ebv)-specific immunoglobulin m (igm) and a diagnosis of infectious mononucleosis was made. a complete blood count and peripheral blood smear demonstrated mild anemia, thrombocytopenia, and neutropenia with leukocytes that contained large azurophilic and eosinophilic granules. bone marrow examination demonstrated increased hemophagocytic histiocytes along with ... | 2014 | 25051077 |
| natural killer t cell strategies to combat epstein-barr virus infection. | epstein-barr virus (ebv) infection results in rapid loss of cd1d expression from the surface of infected b cells, thus enabling the virus to evade immune recognition by natural killer t (nkt) cells. using pharmacologic means to boost cd1d expression, potent nkt cell effector functions can be elicited toward ebv-infected b cells, suggesting the promise of novel strategies to target ebv-associated diseases such as some b-cell malignancies. | 2014 | 25050206 |
| acute acalculous cholecystitis, a rare complication of epstein-barr virus primary infection: report of two cases and review. | we described two cases of acalculous cholecystitis (aac), due to ebv primary infection in two young caucasian women and we reviewed other reported cases. in contrast with aac of other etiologies, antibiotics and surgery are not useful in the management of aac secondary to ebv. | 2014 | 25049206 |
| childhood epstein-barr virus infection and subsequent risk of psychotic experiences in adolescence: a population-based prospective serological study. | several studies suggest a link between early-life infection and adult schizophrenia. cross-sectional studies have reported: (1) increased prevalence of epstein-barr virus (ebv), a member of the herpesviridae family in schizophrenia; (2) a possible role of herpes simplex virus in cognitive dysfunction in schizophrenia and healthy controls. we report a longitudinal serological study of early-life ebv infection, childhood iq, and subsequent risk of psychotic experiences (pe) in adolescence. | 2014 | 25048425 |
| prognostic significance of cd20 expression and epstein-barr virus (ebv) association in classical hodgkin lymphoma in japan: a clinicopathologic study. | to investigate the clinicopathological significance of cd20 expression and epstein-barr virus (ebv) association in hodgkin and reed-sterberg cells of classical hodgkin lymphoma (chl), cd20 expression and ebv positivity (by eber in situ hybridization) were investigated in 389 chl patients in japan. they included 74 cd20-positive cases (19%) and 315 cd20-negative cases (81%). cd20-positive cases showed significantly older age at onset (p = 0.018) and higher association with ebv (p = 0.002). multiv ... | 2014 | 25047504 |
| clinical and molecular characteristics of chinese patients with x-linked lymphoproliferative syndrome type 1. | x-linked lymphoproliferative syndrome type 1 (xlp1) is a rare inherited, life-threatening immunodeficiency disorder caused by mutations in sh2d1a gene. it affect approximately two to three males per million. fewer than 10 cases with definite gene mutations have been reported in chinese mainland and no rapid diagnosis method has been established. | 2014 | 25044636 |
| acute viral encephalitis co-existing with fulminant hepatitis caused by epstein-barr virus. | 2014 | 25041777 | |
| epstein-barr virus infection induces an increase of t regulatory type 1 cells in hodgkin lymphoma patients. | epstein-barr virus (ebv) is present in the neoplastic cells of around 20-30% of patients with hodgkin lymphoma (hl). although, an immunosuppressive environment is currently described in hl patients, little is known concerning the regulatory mechanism induced by ebv proteins expression in tumour cells. this study aimed to investigate an association between regulatory type 1 cells (tr1) and ebv tissue positivity in hl patients. transcriptomic analysis of both ebv-positive and ebv-negative tumours ... | 2014 | 25041527 |
| engineering large viral dna genomes using the crispr-cas9 system. | manipulation of viral genomes is essential for studying viral gene function and utilizing viruses for therapy. several techniques for viral genome engineering have been developed. homologous recombination in virus-infected cells has traditionally been used to edit viral genomes; however, the frequency of the expected recombination is quite low. alternatively, large viral genomes have been edited using a bacterial artificial chromosome (bac) plasmid system. however, cloning of large viral genomes ... | 2014 | 25040500 |
| anti-ccr4 monoclonal antibody mogamulizumab for the treatment of ebv-associated t- and nk-cell lymphoproliferative diseases. | epstein-barr virus (ebv) infects not only b cells but also t cells and natural killer (nk) cells, and t- and nk-cell lymphoproliferative diseases (t/nk-lpd) that are refractory to conventional chemotherapies may develop. to identify a molecular-targeted therapy for ebv-associated t/nk-lpds, we investigated whether cc chemokine receptor 4 (ccr4) was expressed on ebv-infected t and/or nk cells and whether a humanized anti-ccr4 monoclonal antibody, mogamulizumab, was effective. | 2014 | 25117294 |
| epstein-barr virus-associated t-cell lymphoproliferative disorder affecting skin and lung in an elderly patient. | a 70-year-old man presented with papular skin lesions and was diagnosed with epstein-barr virus (ebv)-associated t-cell lymphoproliferative disorder (t-lpd). the patient showed infiltration of a large number of ebv-encoded rna-positive t cells in the skin and lung, presence of ebv load in the peripheral blood, and expansion of clonal ebv-infected γδ t cells and cd8(+) t cells in the blood and skin, as assessed by ebv-terminal repeat southern blot, t-cell receptor polymerase chain reaction and fl ... | 2014 | 25109697 |
| the tumor marker fascin is induced by the epstein-barr virus-encoded oncoprotein lmp1 via nf-κb in lymphocytes and contributes to their invasive migration. | the actin-bundling protein fascin (fscn1) is a tumor marker that is highly expressed in numerous types of cancer including lymphomas and is important for migration and metastasis of tumor cells. fascin has also been detected in b lymphocytes that are freshly-infected with epstein-barr virus (ebv), however, both the inducers and the mechanisms of fascin upregulation are still unclear. | 2014 | 25105941 |
| clinical and scientific aspects of acetylcholine receptor myasthenia gravis. | myasthenia gravis is a rare disease that causes impairment of the neuromuscular junction. in this review we will focus on the literature published in the last 18 months regarding autoimmune myasthenia gravis caused by antibodies against the nicotinic acetylcholine receptor myasthenia gravis. acetylcholine receptor is the most common target of this autoimmune disease. | 2014 | 25105461 |
| high-throughput sequencing of tcr repertoires in multiple sclerosis reveals intrathecal enrichment of ebv-reactive cd8+ t cells. | epstein-barr virus (ebv) has long been suggested as a pathogen in multiple sclerosis (ms). here, we used high-throughput sequencing to determine the diversity, compartmentalization, persistence, and ebv-reactivity of the t-cell receptor (tcr) repertoires in ms. tcr-β genes were sequenced in paired samples of cerebrospinal fluid (csf) and blood from patients with ms and controls with other inflammatory neurological diseases. the tcr repertoires were highly diverse in both compartments and patient ... | 2014 | 25103993 |
| large scale characterization of the lc13 tcr and hla-b8 structural landscape in reaction to 172 altered peptide ligands: a molecular dynamics simulation study. | the interplay between t cell receptors (tcrs) and peptides bound by major histocompatibility complexes (mhcs) is one of the most important interactions in the adaptive immune system. several previous studies have computationally investigated their structural dynamics. on the basis of these simulations several structural and dynamical properties have been proposed as effectors of the immunogenicity. here we present the results of a large scale molecular dynamics simulation study consisting of 100 ... | 2014 | 25101830 |
| epstein-barr virus-encoded rnas: key molecules in viral pathogenesis. | the epstein-barr virus (ebv) is known as an oncogenic herpesvirus that has been implicated in the pathogenesis of various malignancies. ebv-encoded rnas (ebers) are non-coding rnas expressed abundantly in latently ebv-infected cells. herein, i summarize the current understanding of the functions of ebers, including the interactions with cellular factors through which ebers contribute to ebv-mediated pathogenesis. previous studies have demonstrated that ebers are responsible for malignant phenoty ... | 2014 | 25101570 |
| non-aids-defining cancers. | as hiv-infected patients are living longer, non-aids-defining cancers are increasing in number and now constitute the majority of cancers diagnosed in the hiv-infected population. the excess incidence of hodgkin lymphoma and head and neck and liver cancers has been increasing among hiv-infected individuals. breast and lung cancers appear to occur earlier in the hiv-infected population; hodgkin lymphoma appears to have a later onset, reflecting the fact that most cases in the hiv-infected populat ... | 2014 | 25101532 |
| the epstein-barr virus (ebv) glycoprotein b cytoplasmic c-terminal tail domain regulates the energy requirement for ebv-induced membrane fusion. | the entry of enveloped viruses into host cells is preceded by membrane fusion, which in epstein-barr virus (ebv) is thought to be mediated by the refolding of glycoprotein b (gb) from a prefusion to a postfusion state. in our current studies, we characterized a gb c-terminal tail domain (ctd) mutant truncated at amino acid 843 (gb843). this truncation mutant is hyperfusogenic as monitored by syncytium formation and in a quantitative fusion assay and is dependent on gh/gl for fusion activity. gb8 ... | 2014 | 25100836 |
| epstein-barr virus-encoded latent membrane protein 2a promotes the epithelial-mesenchymal transition in nasopharyngeal carcinoma via metastatic tumor antigen 1 and mechanistic target of rapamycin signaling induction. | epstein-barr virus-encoded latent membrane protein 2a (lmp2a) promotes the epithelial-mesenchymal transition (emt) of nasopharyngeal carcinoma (npc), thereby increasing tumor invasion. recently, the dysregulation of metastatic tumor antigen 1 (mta1) was found to enhance tumor metastasis in a variety of cancers. a molecular connection between these two proteins has been proposed but not firmly established. in this study, we reported the overexpression of mta1 in 29/60 (48.3%) npc patients, and th ... | 2014 | 25100829 |
| viruses: are they really culprits for periodontal disease? a critical review? | 2014 | 25099706 | |
| primary cutaneous follicle center lymphoma with hodgkin and reed-sternberg-like cells: a new histopathologic variant. | primary cutaneous follicle center lymphoma (pcfcl) is the most frequent cutaneous b-cell lymphoma. a 62-year-old man presented with a solitary indolent subcutaneous nodule for 3 years duration, without other abnormalities. histological examination showed lymphoproliferation with a nodular growth pattern characterized by fibrous collagen bands surrounding nodules. the nodules were composed of medium-sized centrocytes admixed with many large multilobulated and lacunar cells without eosinophils or ... | 2014 | 25099172 |
| epstein-barr virus in multiple sclerosis. | multiple sclerosis (ms) is an inflammatory disorder of the central nervous system. many diseases are associated with epstein-barr virus (ebv) infection, such as infectious mononucleosis and many types of malignancies, and it is thought to be related to some diseases of autoimmune origin, such as rheumatoid arthritis, systemic lupus erythematosis, and others. the present study aimed to assess ebv in patients with ms. | 2014 | 25162741 |
| medical management of children after liver transplantation. | successful outcomes in patient, graft survival, and quality of life depend on the prevention, early detection, and treatment of possible complications. the aim of the study was to highlight the common outcomes focusing on the unique features in children. medical follow-up of children after liver transplantation includes monitoring of surgical complications: biliary and vascular, rejection, infections, posttransplant lymphoproliferative disease, other malignancies, recurrent disease, graft functi ... | 2014 | 25162538 |
| epstein-barr virus-associated posttransplant lymphoproliferative disorder after allogeneic stem cell transplantation. | epstein-barr virus (ebv)-associated posttransplant lymphoproliferative disorder is an increasingly life-threatening complication after allogeneic stem cell transplantation with the use of more complex transplant procedures. | 2014 | 25162331 |
| association of epstein-barr virus with invasive breast carcinoma and its impact on well-known clinicopathologic parameters in iranian women. | the association between epstein-barr virus (ebv) and breast carcinoma in iranian women is uncertain. we examined ebv latent membrane protein-1 (lmp-1) antigen expression in breast carcinoma and its relationship with clinicopathologic parameters among a population of iranian patients. | 2014 | 25161988 |
| identification of antibody glycosylation structures that predict monoclonal antibody fc-effector function. | to determine monoclonal antibody (mab) features that predict fragment crystalizable (fc)-mediated effector functions against hiv. | 2014 | 25160934 |
| epstein-barr virus lymphoproliferative disease after hematopoietic stem cell transplant. | epstein-barr virus (ebv) reactivation can cause significant morbidity and mortality after allogeneic hematopoietic stem cell transplant. delays in reconstitution of ebv-specific t lymphocyte activity can lead to life-threatening ebv lymphoproliferative disease (ebv-ptld). this review highlights recent advances in the understanding of pathophysiology, risk factors, diagnosis, and management of ebv viremia and ptld. | 2014 | 25159713 |
| rna-guided endonuclease provides a therapeutic strategy to cure latent herpesviridae infection. | latent viral infection is a persistent cause of human disease. although standard antiviral therapies can suppress active viral replication, no existing treatment can effectively eradicate latent infection and therefore a cure is lacking for many prevalent viral diseases. the prokaryotic immune system clustered regularly interspaced short palindromic repeat (crispr)/cas evolved as a natural response to phage infections, and we demonstrate here that the crispr/cas9 system can be adapted for antivi ... | 2014 | 25157128 |
| combination of saha and bortezomib up-regulates cdkn2a and cdkn1a and induces apoptosis of epstein-barr virus-positive wp-restricted burkitt lymphoma and lymphoblastoid cell lines. | epstein-barr virus (ebv) latent proteins exert anti-apoptotic effects on ebv-transformed lymphoid cells by down-regulating bcl2l11 (bim), cdkn2a (p16(ink4a) ) and cdkn1a (p21(waf1) ). however, the potential therapeutic effects of targeting these anti-apoptotic mechanisms remain unexplored. here, we tested both in vitro and in vivo effects of the combination of histone deacetylase (hdac) and proteasome inhibitors on the apoptosis of six endemic burkitt lymphoma (bl) lines of different latency pat ... | 2014 | 25155625 |
| oxysterols act as promiscuous ligands of class-a gpcrs: in silico molecular modeling and in vitro validation. | according to classical pharmacology, each neurotransmitter/hormonal receptor, including gpcrs, is exclusively activated by highly specific ligands. however, recent evidence challenges this dogma. oxysterols are produced at inflammatory sites and can surprisingly potently activate the epstein barr virus induced gene receptor-2 (ebi2), a gpcr involved in adaptive immune responses. similarly, oxysterols promiscuously operate cxcr2, a chemokine receptor participating to immune reactions and cancer d ... | 2014 | 25152366 |
| large b-cell lymphoma of the base of the tongue and oral cavity: a practical approach to identifying prognostically important subtypes. | the aim of this study is to illustrate a practical approach to the identification of prognostically important subtypes of large b-cell lymphomas. | 2014 | 25151588 |
| a complex role of herpes viruses in the disease process of multiple sclerosis. | multiple sclerosis (ms) is a chronic inflammatory disorder of the central nervous system (cns). neither the antigenic target(s) nor the cell population(s) responsible for cns tissue destruction in ms have been fully defined. the objective of this study was to simultaneously determine the antigen (ag)-specificity and phenotype of un-manipulated intrathecal cd4+ and cd8+ t cells of patients with relapsing-remitting and progressive ms compared to subjects with other inflammatory neurological diseas ... | 2014 | 25148387 |
| cytotoxic and nitric oxide production-inhibitory activities of limonoids and other compounds from the leaves and bark of melia azedarach. | nine limonoids, 1-9, one apocarotenoid, 11, one alkaloid, 12, and one steroid, 13, from the leaf extract; and one triterpenoid, 10, five steroids, 14-18, and two flavonoids, 19 and 20, from the bark extract of melia azedarach l. (chinaberry tree; meliaceae) were isolated. among these compounds, three compounds, 4-6, were new, and their structures were established as 3-deacetyl-28-oxosalannolactone, 3-deacetyl-28-oxosalanninolide, and 3-deacetyl-17-defurano-17,28-dioxosalannin, respectively, on t ... | 2014 | 25146759 |
| management of inflammatory bowel disease patients with a cancer history. | in inflammatory bowel disease (ibd) patients, thiopurines promote carcinogenesis of epstein-barr virus (ebv)-related lymphomas, non-melanoma skin cancers and urinary tract cancers, while anti-tnf agents could promote carcinogenesis of melanomas. patients with ibd and previous cancer are at a higher risk of developing new or recurrent cancer than ibd patients without a history of cancer, irrespective of the use of immunosuppressants. in transplant recipients, the use of thiopurines is associated ... | 2014 | 25146698 |
| assembly and architecture of the ebv b cell entry triggering complex. | epstein-barr virus (ebv) is an enveloped double-stranded dna virus of the gammaherpesvirinae sub-family that predominantly infects humans through epithelial cells and b cells. three ebv glycoproteins, gh, gl and gp42, form a complex that targets ebv infection of b cells. human leukocyte antigen (hla) class ii molecules expressed on b cells serve as the receptor for gp42, triggering membrane fusion and virus entry. the mechanistic role of ghgl in herpesvirus entry has been largely unresolved, but ... | 2014 | 25144748 |