Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| severe xlp phenotype caused by a novel intronic mutation in the sh2d1a gene. | we describe here a novel c.137 + 5g > a intronic mutation in the sh2d1a gene of the signaling lymphocyte activation molecule (slam)-associated protein (sap) in association with epstein-barr virus (ebv)-induced fatal infectious mononucleosis (fim) in an 8-year-old male patient and his 3-year-old step brother. the mother and the maternal grandmother of the boys are healthy and heterozygous for this sequence variant. genetic sequencing of blood-cell-derived cdna in the younger patient revealed a 22 ... | 2015 | 25491288 |
| incidence, presentation, and prognosis of malignancies in ataxia-telangiectasia: a report from the french national registry of primary immune deficiencies. | biallelic mutations in atm cause ataxia-telangiectasia (at), a rare inherited disease with a high incidence of cancer. precise estimates of the risk, presentation, and outcomes of cancer in patients with at need to be addressed in large series. | 2015 | 25488969 |
| strategies of oncogenic microbes to deal with ww domain-containing oxidoreductase. | ww domain-containing oxidoreductase (wwox) is a well-documented tumor suppressor protein that controls growth, survival, and metastasis of malignant cells. to counteract wwox's suppressive effects, cancer cells have developed many strategies either to downregulate wwox expression or to functionally inactivate wwox. relatively unknown is, in the context of those cancers associated with certain viruses or bacteria, how the oncogenic pathogens deal with wwox. here we review recent studies showing d ... | 2015 | 25488911 |
| hydroa vacciniforme-like lymphoma misdiagnosed as cutaneous lupus erythematosus. | 2015 | 25488018 | |
| impact of serotherapy on immune reconstitution and survival outcomes after stem cell transplantations in children: thymoglobulin versus alemtuzumab. | the outcome of allogeneic hematopoietic stem cell transplantation (hsct) is strongly affected by the kinetics of reconstitution of the immune system. this study compared the effects of antithymocyte globulin (atg) and alemtuzumab on various outcome parameters after hsct. the study cohort consisted of 148 children, with a median age of 9.6 years (range, .4 to 19.0), who underwent hsct for malignant and benign hematological disorders in a single hsct unit. conditioning included atg (n = 110) or al ... | 2015 | 25485863 |
| lmp1-deficient epstein-barr virus mutant requires t cells for lymphomagenesis. | epstein-barr virus (ebv) infection transforms b cells in vitro and is associated with human b cell lymphomas. the major ebv oncoprotein, latent membrane protein 1 (lmp1), mimics constitutively active cd40 and is essential for outgrowth of ebv-transformed b cells in vitro; however, ebv-positive diffuse large b cell lymphomas and burkitt lymphomas often express little or no lmp1. thus, ebv may contribute to the development and maintenance of human lymphomas even in the absence of lmp1. here, we fo ... | 2015 | 25485679 |
| rabbit anti-t cell globulin in allogeneic hematopoietic cell transplantation. | anti-t cell globulin (atg) is polyclonal igg from rabbits immunized with human thymocytes or a human t cell line. prophylaxis using atg infused with conditioning for adult marrow or blood stem cell transplantation reduces both acute and chronic graft-versus-host disease (gvhd). however, atg is not or minimally efficacious in steroid refractory gvhd treatment. regarding preemptive therapy, atg is promising; however, further work is needed on establishing adequate biomarkers to be used as triggers ... | 2015 | 25482864 |
| high-sensitivity c-reactive protein complements plasma epstein-barr virus deoxyribonucleic acid prognostication in nasopharyngeal carcinoma: a large-scale retrospective and prospective cohort study. | to evaluate the effects of combining the assessment of circulating high-sensitivity c-reactive protein (hs-crp) with that of epstein-barr virus dna (ebv dna) in the pretherapy prognostication of nasopharyngeal carcinoma (npc). | 2015 | 25482300 |
| the novel panel assay to define tumor-associated antigen-binding antibodies in patients with metastatic melanomas may have diagnostic value. | we aim to harness the natural humoral immune response by various technologies to get novel biomarkers. a complex antibody analysis in sera and in the tumor microenvironment leads to reveal tumor-specific antibodies. more strategies were introduced to select the most effective one to identify potential tumor antigen-binding capacity of the host. epstein-barr virus transformation and cloning with limiting dilution assay, magnetic cell sorting and antibody phage display with further methodological ... | 2015 | 25480739 |
| characterization of the nasopharyngeal carcinoma methylome identifies aberrant disruption of key signaling pathways and methylated tumor suppressor genes. | nasopharyngeal carcinoma (npc) is a common tumor consistently associated with epstein-barr virus infection and prevalent in south china, including hong kong, and southeast asia. current genomic sequencing studies found only rare mutations in npc, indicating its critical epigenetic etiology, while no epigenome exists for npc as yet. | 2015 | 25479246 |
| ebv-positive diffuse large b-cell lymphoma in young adults: is this a distinct disease entity? | epstein-barr virus (ebv)-positive diffuse large b-cell lymphoma (dlbcl) of the elderly is defined only in adults older than 50 years. however, ebv-positive dlbcl can affect younger patients. we investigated the prevalence, clinical characteristics and survival outcomes of ebv-positive dlbcl in young adults. | 2015 | 25475080 |
| in acpa-positive ra patients, antibodies to ebna35-58cit, a citrullinated peptide from the epstein-barr nuclear antigen-1, strongly cross-react with the peptide β60-74cit which bears the immunodominant epitope of citrullinated fibrin. | although several infectious agents and particularly epstein-barr virus (ebv) have been suspected to be involved in aetiology of rheumatoid arthritis (ra), their role still remains elusive. almost 80% of ra sera contain antibodies to citrullinated proteins/peptides. among them, the autoantibodies to citrullinated human fibrinogen (ahfiba) are composed of two non-cross-reactive subsets directed to immunodominant epitopes borne by the α36-50cit and β60-74cit fibrin peptides. ra sera also contain an ... | 2015 | 25407647 |
| acneiform primary cutaneous cd4-positive small/medium pleomorphic t-cell lymphoma with prominent necrosis. | primary cutaneous cd4-positive small/medium pleomorphic t-cell lymphoma (smptcl) is an indolent form of cutaneous lymphoma that usually presents in solitary fashion and is histopathologically characterized by nodular infiltration of small- to medium-sized pleomorphic t-cells. we report the case of a patient who presented with a 5-year history of acneiform lesions on his face. histopathologic examination of two lesions revealed a nodular infiltrate of small to medium-sized lymphocytes with necros ... | 2015 | 25407448 |
| ultra-endurance exercise induces stress and inflammation and affects circulating hematopoietic progenitor cell function. | although amateur sports have become increasingly competitive within recent decades, there are as yet few studies on the possible health risks for athletes. this study aims to determine the impact of ultra-endurance exercise-induced stress on the number and function of circulating hematopoietic progenitor cells (cpcs) and hematological, inflammatory, clinical, metabolic, and stress parameters in moderately trained amateur athletes. following ultra-endurance exercise, there were significant increa ... | 2015 | 25438993 |
| primary diffuse large b-cell lymphoma of the ovary is of a germinal centre b-cell-like phenotype. | primary ovarian lymphoma is rare. to better understand the clinicopathological and molecular features of these tumours, we studied 14 patients (age range 13 to 74 years, mean 46.9 years) with non-hodgkin's lymphoma who initially presented with an ovarian tumour. the clinicopathological features were reviewed and tissue samples were studied by immunohistochemistry and for immunoglobulin gene rearrangement, presence of epstein barr virus and for myc and bcl-2 rearrangements by fluorescence in situ ... | 2015 | 25403088 |
| epstein-barr virus latent membrane protein 2a suppresses the expression of her2 via a pathway involving twist and yb-1 in epstein-barr virus-associated gastric carcinomas. | to explore her2 expression in epstein-barr virus-associated gastric carcinoma (ebvagc) and the possible mechanisms causing down-regulation of her2 expression in ebvagc, we first evaluated her2 and lmp2a expression on a clinicopathological-features matched cohort including 78 ebvagc and 216 ebv-negative gastric carcinoma (ebvngc) cases by immunohistochemistry. cases with high her2 expression in ebvagc were significantly less than in ebvngc (5.1% versus 23.7%; p<0.001), and none of the 34 lmp2a+ e ... | 2015 | 25402957 |
| human interferon regulatory factor 5 homologous epitopes of epstein-barr virus and mycobacterium avium subsp. paratuberculosis induce a specific humoral and cellular immune response in multiple sclerosis patients. | a large number of reports indicate the association of epstein-barr virus (ebv), and mycobacterium avium subsp. paratuberculosis (map) with multiple sclerosis (ms). | 2015 | 25392335 |
| proven epstein-barr encephalitis with negative ebv-dna load in cerebrospinal fluid after allogeneic hematopoietic stem cell transplantation in a child with acute lymphoblastic leukemia. | we report a case of ebv encephalitis in a seven-yr-old child with ph+ all. two months after an allogeneic hsct from his hla mismatched mother, the patient showed an altered sensorium, generalized seizures, and a left hemiparesis. brain mri demonstrated multiple lesions highly suggestive for viral encephalitis. blood and csf pcr analyses were negative for the most common viruses involved in immunocompromised patients including ebv. a cerebral biopsy was performed, which showed intense gliosis and ... | 2015 | 25388950 |
| the translation inhibitor silvestrol exhibits direct anti-tumor activity while preserving innate and adaptive immunity against ebv-driven lymphoproliferative disease. | treatment options for patients with epstein-barr virus-driven lymphoproliferative diseases (ebv-lpd) are limited. chemo-immunotherapeutic approaches often lead to immune suppression, risk of lethal infection and ebv reactivation, thus it is essential to identify agents that can deliver direct anti-tumor activity while preserving innate and adaptive host immune surveillance. silvestrol possesses direct anti-tumor activity in multiple hematologic malignancies while causing minimal toxicity to norm ... | 2015 | 25393910 |
| retinopathy in a patient with acute epstein-barr virus infection: follow-up analysis using spectral domain optical coherence tomography. | to describe the clinical findings, diagnostics, and differential diagnosis in a patient with retinopathy in acute systemic epstein-barr virus (ebv) infection. | 2015 | 25383851 |
| epstein-barr virus-associated t/natural killer-cell lymphoproliferative disorder in children and young adults has similar molecular signature to extranodal nasal natural killer/t-cell lymphoma but shows distinctive stem cell-like phenotype. | we performed gene expression profiling in epstein-barr virus (ebv)-associated t/natural killer (nk)-cell lymphoproliferative disorder in children and young adults (tnklpdc) in order to understand the molecular pathways deregulated in this disease and compared it with nasal-type nk/t-cell lymphoma (nktl). the molecular and phenotypic signature of tnklpdc is similar to nktl, with overexpression of p53, survivin and ezh2. down-regulation of ezh2 in tnklpdc cell lines led to an increase in apoptosis ... | 2015 | 25382618 |
| clonal epstein-barr virus-positive mucocutaneous ulcer mimicking a mature b-cell lymphoma in a patient with mycophenolate-induced immune suppression. | 2015 | 25379620 | |
| expression of the epidermodysplasia verruciformis-associated genes ever1 and ever2 is activated by exogenous dna and inhibited by lmp1 oncoprotein from epstein-barr virus. | ever1 and ever2 are mutated in epidermodysplasia verruciformis patients, who are susceptible to human betapapillomavirus (hpv) infection. it is unknown whether their products control the infection of other viruses. here, we show that the expression of both genes in b cells is activated immediately after epstein-barr virus (ebv) infection, whereas at later stages, it is strongly repressed via activation of the nf-κb signaling pathway by latent membrane protein 1 (lmp1). ectopic expression of ever ... | 2015 | 25378492 |
| managing the challenge of ptld in liver and bowel transplant recipients. | post-transplant lymphoproliferative disorder (ptld) remains a common complication of liver and bowel transplantion. the ubiquity of epstein-barr virus (ebv) combined with engraftment of organs rich with lymphatic tissue and the requirement of highly immunosuppressive regimens are factors that account for the high frequency and poor prognosis of ptld in this population. early detection of the virus followed by pre-emptive reduction of immunosuppression are essential components in the management o ... | 2015 | 25377273 |
| histopathologic and immunohistological evaluation of anaplastic large cell lymphoma with epstein-barr virus in an orangutan (pongo pygmaeus). | an 18-month-old female orangutan (pongo pygmaeus) died after exhibiting fever, cough, and rapid breathing. | 2015 | 25376634 |
| vitreous evaluation: a diagnostic challenge. | to categorize vitrectomy cytologic diagnoses and ancillary tests to address appropriate processing of low-volume vitreous samples. | 2015 | 25439597 |
| analytical and clinical performance of a new molecular assay for epstein-barr virus dna quantitation. | quantitation of ebv dna has been shown to be a useful tool to identify and monitor patients with immunosuppression and high risk for ebv-associated disease. in this study, the analytical and clinical performance of the new realquality rs-ebv kit (ab analitica, padova, italy) was investigated. the clinical performance was compared to that of the ebv r-gene (biomerieux, varilhes, france) assay. when the accuracy of the new assay was tested, all results except of one were found to be within ±0.5log ... | 2015 | 25445796 |
| [aids-related primary cns non-hodgkin's lymphoma in a patient with previous epstein-barr virus panuveitis. a clinico-pathological report]. | patient with aids and epstein-barr virus (ebv) uveitis. the pcr of the aqueous and vitreous humor was positive for ebv, and dna quantification was 56.602×10(6) copies/ml in the vitreous humor, 173,400 copies/ml in the peripheral blood, and negative in the cerebrospinal fluid (csf). the patient developed a non-hodgkin's lymphoma (nhl), diagnosed in the autopsy. | 2015 | 25443210 |
| brainstem lymphoma in a myasthenia gravis patient on azathioprine. | azathioprine is used for immunosuppression in myasthenia gravis (mg). we report a patient with seropositive mg who developed a brainstem lymphoma 4 years after being treated with azathioprine and review the literature on the occurrence of lymphoma in this patient population. an 82-year-old man with ocular mg who had been on azathioprine for 4 years developed subacute worsening of bulbar symptoms including diplopia, dysarthria and dysphagia mimicking mg exacerbation. neuroimaging followed by biop ... | 2015 | 25443086 |
| ifn-β and multiple sclerosis: from etiology to therapy and back. | several immunomodulatory treatments are currently available for relapsing-remitting forms of multiple sclerosis (rrms). interferon beta (ifn) was the first therapeutic intervention able to modify the course of the disease and it is still the most used first-line treatment in rrms. though two decades have passed since ifn-β was introduced in the management of ms, it remains a valid approach because of its good benefit/risk profile. this is witnessed by new efforts of pharmaceutical industry to im ... | 2015 | 25466632 |
| differential proteomic analysis of endemic and sporadic epstein-barr virus-positive and negative burkitt lymphoma. | burkitt lymphoma (bl) is the most common non-hodgkin lymphoma in children worldwide and the most common paediatric malignancy in sub-saharan africa. the endemic (ebl) and sporadic (sbl) variants have distinct epidemiologic and virologic characteristics. although gene expression studies have defined the transcriptional profiles of both, their proteomic signatures have not been studied. | 2015 | 25466511 |
| unexpected patterns of epstein-barr virus transcription revealed by a high throughput pcr array for absolute quantification of viral mrna. | we have validated a flexible, high-throughput and relatively inexpensive rt-qpcr array platform for absolute quantification of epstein-barr virus transcripts in different latent and lytic infection states. several novel observations are reported. first, during infection of normal b cells, wp-initiated latent gene transcripts remain far more abundant following activation of the cp promoter than was hitherto suspected. second, ebna1 transcript levels are remarkably low in all forms of latency, typ ... | 2015 | 25463610 |
| thymoglobulin and an unexpected outbreak of epstein-barr virus. | 2015 | 25459641 | |
| oxysterols regulate encephalitogenic cd4(+) t cell trafficking during central nervous system autoimmunity. | perturbation of steroids pathways is linked to inflammation and chronic diseases, however the underlying mechanism remains unclear. oxysterols, oxidized forms of cholesterol, are not only essential for bile synthesis and sterol transportation but have recently been shown to contribute to the immune response. in addition, serum oxysterols levels have been proposed as suitable candidate biomarkers for neurological diseases such as multiple sclerosis (ms). however how oxysterols modulate adaptive i ... | 2015 | 25456971 |
| use of serial assessment of disease severity and liver biopsy for indication for liver transplantation in pediatric epstein-barr virus-induced fulminant hepatic failure. | the decision to perform liver transplantation (lt) in patients with epstein-barr virus (ebv)-induced fulminant hepatic failure (fhf) relies on a precise assessment of laboratory and pathological findings. in this study, we analyzed clinical and laboratory data as well as the pathological features of the liver in order to evaluate the pathogenesis and the need for lt in 5 patients with ebv-induced fhf. according to the king's college criteria, the acute liver failure early dynamic (alfed) model, ... | 2015 | 25452116 |
| epstein-barr virus mir-bart20-5p regulates cell proliferation and apoptosis by targeting bad. | although epstein-barr virus (ebv) bamhi a rightward transcript (bart) micrornas (mirnas) are ubiquitously expressed in ebv-associated tumors, the role of most bart mirnas is unclear. in this study, we showed that bcl-2-associated death promoter (bad) expression was significantly lower in ebv-infected ags-ebv cells than in ebv-negative ags cells and investigated whether bart mirnas target bad. using bioinformatics analysis, five bart mirnas showing seed match with the 3' untranslated region (3'-u ... | 2015 | 25449437 |
| belatacept-based, atg-fresenius-induction regimen for kidney transplant recipients: a proof-of-concept study. | belatacept provides effective immunosuppression while avoiding the nephrotoxicities associated with calcineurin inhibitors (cnis). however, existing belatacept-based regimens still have high rates of acute rejection. we hypothesized that therapy with belatacept, mycophenolic acid (mma), steroids and induction therapy with rabbit anti-thymocyte globulin fresenius (atgf), rejection rate could be reduced. prospective, single center, proof-of-concept study including males and females aged ≥18years, ... | 2015 | 25448417 |
| hodgkin-like peripheral t-cell lymphoma (ptcl) with preserved hodgkin-like lesions at autopsy: a case report with an interesting clinical course. | the presence of the so-called hodgkin and reed-sternberg (h-rs) like cells may occur in t-cell non-hodgkin lymphoma. reported herein is the autopsy case of hodgkin-like peripheral t-cell lymphoma (ptcl) in a 77-year-old male with gradual submandibular lymph node enlargement. the first biopsy showed hodgkin-like ptcl, initially misdiagnosed as classical hodgkin lymphoma. although he was treated with a regimen of abvd, his disease recurred with cervical lymph node enlargement. a second biopsy show ... | 2015 | 25434605 |
| epstein-barr virus persistence and reactivation in neuromyelitis optica. | epstein-barr virus (ebv) infection has been thought to be a key environmental factor in the development of multiple sclerosis (ms). the aim of this study is to investigate the association of ebv infection with neuromyelitis optica (nmo). | 2015 | 25433035 |
| pulmonary lymphomatoid granulomatosis in a 4-year-old girl. | lymphomatoid granulomatosis is a rare lymphoproliferative disease associated with the epstein-barr virus that commonly affects the lung. there is limited literature on cases of pediatric lymphomatoid granulomatosis. half of all cases of lymphomatoid granulomatosis develop during the treatment of leukemia. herein, we describe a case of lymphomatoid granulomatosis in a previously healthy child without leukemia. | 2015 | 25432443 |
| a pediatric case with vasculitis-like viral eruption induced by epstein-barr virus. | 2015 | 25431017 | |
| host genetics of epstein-barr virus infection, latency and disease. | epstein-barr virus (ebv) infects 95% of the adult population and is the cause of infectious mononucleosis. it is also associated with 1% of cancers worldwide, such as nasopharyngeal carcinoma, hodgkin's lymphoma and burkitt's lymphoma. human and cancer genetic studies are now major forces determining gene variants associated with many cancers, including nasopharyngeal carcinoma and hodgkin's lymphoma. host genetics is also important in infectious disease; however, there have been no large-scale ... | 2015 | 25430668 |
| clinicopathological characteristics and rituximab addition to cytotoxic therapies in patients with rheumatoid arthritis and methotrexate-associated large b lymphoproliferative disorders. | to analyse the clinicopathological characteristics and prognosis of 40 rheumatoid arthritis (ra) patients with methotrexate (mtx)-associated large b cell lymphoproliferative disorders (mtx-blpd). | 2015 | 25429725 |
| tracheobronchial anomalies in a patient with schimke immuno-osseous dysplasia (siod). | schimke immuno-osseous dysplasia (siod) is a rare genetic disorder with multiple systemic manifestations. pulmonary manifestations have been described but not well characterized. they are believed to be secondary to decreased elasticity, and include emphysema, pulmonary hypertension and bronchiectasis. we describe a 24-year-old female patient with siod with tracheobronchial anomalies not reported before, including tracheomalacia and a tracheal bronchus with epstein-barr virus (ebv) related leiom ... | 2015 | 25428399 |
| human leukocyte antigen type and posttransplant lymphoproliferative disorder. | posttransplant lymphoproliferative disorder (ptld) is an infrequent but serious complication of solid organ transplantation. early detection and initiation of therapy may improve outcomes. the purpose of this study was to identify human leukocyte antigen (hla) type as risk and prognostic factors for ptld. | 2015 | 25427163 |
| gcn5 inhibits xbp-1s-mediated transcription by antagonizing pcaf action. | cellular unfolded protein response (upr) is induced when endoplasmic reticulum (er) is under stress. xbp-1s, the active isoform of x-box binding protein 1 (xbp-1), is a key regulator of upr. previously, we showed that a histone acetyltransferase (hat), p300/cbp-associated factor (pcaf), binds to xbp-1s and functions as an activator of xbp-1s. here, we identify general control nonderepressible 5 (gcn5), a hat with 73% identity to pcaf, as a novel xbp-1s regulator. both pcaf and gcn5 bind to the s ... | 2015 | 25426559 |
| contemporary management and classification of hepatic leiomyosarcoma. | hepatic leiomyosarcomas are rare soft-tissue tumours. the majority of lesions previously considered as leiomyosarcomas have been identified as gastrointestinal stromal tumours (gists). consequently, understanding of the role of liver resection for true leiomyosarcoma is limited, a fact that is exacerbated by the increasing recognition of leiomyosarcoma subtypes. this study presents data on the outcomes of liver resection for leiomyosarcoma and suggests an algorithm for its pathological assessmen ... | 2015 | 25418451 |
| murine gammaherpesvirus-68 (mhv-68) is not horizontally transmitted amongst laboratory mice by cage contact. | murine gammaherpesvirus-68 (mhv-68), a natural pathogen of mice, is being evaluated as a model of epstein barr virus (ebv) infection for use in investigation of the effects of immunomodulatory therapy on herpesvirus pathogenesis in humans. immunosuppressive agents are used for treatment of a variety of autoimmune diseases as well as for prevention of tissue rejection after organ transplantation and can result in recrudescence of latent herpesvirus infections. prior to examination of mhv-68 as a ... | 2015 | 25412621 |
| cellular differentiation regulator blimp1 induces epstein-barr virus lytic reactivation in epithelial and b cells by activating transcription from both the r and z promoters. | epstein-barr virus (ebv) maintains a lifelong latent infection within a subset of its host's memory b cells, while lytic ebv replication takes place in plasma cells and differentiated epithelial cells. therefore, cellular transcription factors, such as blimp1, that are key mediators of differentiation likely contribute to the ebv latent-to-lytic switch. previous reports showed that ectopic blimp1 expression induces reactivation in some ebv-positive (ebv(+)) b-cell lines and transcription from zp ... | 2015 | 25410866 |
| bglf4 kinase modulates the structure and transport preference of the nuclear pore complex to facilitate nuclear import of epstein-barr virus lytic proteins. | bglf4 kinase, the only ser/thr protein kinase encoded by the epstein-barr virus (ebv) genome, phosphorylates multiple viral and cellular substrates to optimize the cellular environment for viral dna replication and the nuclear egress of nucleocapsids. previously, we found that nuclear targeting of bglf4 is through direct interaction with the fg repeat-containing nucleoporins (fg-nups) nup62 and nup153 independently of cytosolic transport factors. here, we investigated the regulatory effects of b ... | 2015 | 25410863 |
| pseudocarcinomatous hyperplasia mimicking squamous cell carcinoma in a case of cd56-positive cytotoxic t-cell lymphoma. | we present the case of an 84-year-old patient with a cutaneous cd56 positive cytotoxic t-cell lymphoma associated with substantial pseudocarcinomatous hyperplasia mimicking squamous cell carcinoma (scc). the patient presented with a 7-month history of several progressive, ulcerated plaques on his right forearm. an initial biopsy showed changes consistent with a diagnosis of scc for which the patient underwent surgical treatment. several months later, the patient developed recurrent ulcerated pla ... | 2015 | 25370871 |
| role of atm in the formation of the replication compartment during lytic replication of epstein-barr virus in nasopharyngeal epithelial cells. | epstein-barr virus (ebv), a type of oncogenic herpesvirus, is associated with human malignancies. previous studies have shown that lytic reactivation of ebv in latently infected cells induces an atm-dependent dna damage response (ddr). the involvement of atm activation has been implicated in inducing viral lytic gene transcription to promote lytic reactivation. its contribution to the formation of a replication compartment during lytic reactivation of ebv remains poorly defined. in this study, t ... | 2015 | 25355892 |
| t cell epitope clustering in the highly immunogenic bzlf1 antigen of epstein-barr virus. | polymorphism in the human leukocyte antigen (hla) loci ensures that the cd8(+) t cell response to viruses is directed against a diverse range of antigenic epitopes, thereby minimizing the impact of virus escape mutation across the population. the bzlf1 antigen of epstein-barr virus is an immunodominant target for cd8(+) t cells, but the response has been characterized only in the context of a limited number of hla molecules due to incomplete epitope mapping. we have now greatly expanded the numb ... | 2015 | 25355876 |
| high-throughput rna sequencing-based virome analysis of 50 lymphoma cell lines from the cancer cell line encyclopedia project. | using high-throughput rna sequencing data from 50 common lymphoma cell culture models from the cancer cell line encyclopedia project, we performed an unbiased global interrogation for the presence of a panel of 740 viruses and strains known to infect human and other mammalian cells. this led to the findings of previously identified infections by epstein-barr virus (ebv), kaposi's sarcoma herpesvirus (kshv), and human t-lymphotropic virus type 1 (htlv-1). in addition, we also found a previously u ... | 2015 | 25355872 |
| sequence variation of epstein-barr virus (ebv) bcrf1 in lymphomas in non-endemic areas of nasopharyngeal carcinoma. | to characterize the sequence variation and the potential implication of the epstein-barr virus (ebv) oncogene in lymphoma, bamhi-c fragment rightward reading frame 1 (bcrf1) was sequenced in different types of ebv-positive lymphoma in northern china, and polymorphisms were compared with previous variation data from other malignancies. the dominate subtype of bcrf1 in ebv-positive lymphoma was the b95-8 prototype, and a mutation in the signal peptide was more strongly associated with hodgkin's ly ... | 2015 | 25373543 |
| lymphomatoid granulomatosis presenting with cutaneous involvement: a case report and review of the literature. | lymphomatoid granulomatosis (lg) is a rare epstein-barr virus (ebv)-associated b-cell lymphoproliferative disorder presenting in middle adulthood that nearly always affects the lungs and shows cutaneous involvement in up to 50% of cases. skin lesions are present at the time of diagnosis in roughly one-third of patients and may precede the development of lung lesions in as many as 10-15%. recognition by both the dermatologist and dermatopathologist is therefore crucial for early and accurate diag ... | 2015 | 25355540 |
| epstein-barr virus-negative diffuse large b-cell lymphoma hosts intra- and peritumoral b-cells with activated epstein-barr virus. | although the vast majority of diffuse large b-cell lymphomas (dlbcl) are negative for the epstein-barr virus (ebv), a subset of dlbcl in immunocompetent patients carries ebv in the lymphoma cells and expresses ebv-encoded rna and/or proteins. ebv-positive dlbcl are rare and represent either pyothorax associated dlbcl or ebv-positive dlbcl of the elderly. in all cases of ebv-positive dlbcl, ebv is detectable in virtually all lymphoma cells, indicating that ebv was present at an initial phase of l ... | 2015 | 25339301 |
| epstein-barr virus (ebv)-positive sporadic burkitt lymphoma: an age-related lymphoproliferative disorder? | epstein-barr virus (ebv) is detected in 20% to 30% of sporadic burkitt lymphoma (sbl). however, only a few studies of ebv-positive (ebv) sbl have been reported, and its characteristics still remain controversial. to highlight the features of ebv sbl, we compared the clinicopathologic characteristics of 33 cases of ebv and 117 cases of ebv-negative (ebv) sbl in japan. ebv sbl showed significantly higher age distribution (median, 42 vs. 13 y; p<0.0001) and higher frequency of patients older than 5 ... | 2015 | 25321330 |
| lymphomatoid granulomatosis--a single institute experience: pathologic findings and clinical correlations. | lymphomatoid granulomatosis (lyg) is a rare angiocentric and angiodestructive epstein-barr virus (ebv)-associated b-cell lymphoproliferative disorder. it is hypothesized that these patients have dysregulated immune surveillance of ebv. we reviewed the biopsies of 55 patients with lyg who were referred for a prospective trial at the national cancer institute (1995 to 2010) and evaluated the histologic, immunohistochemical, in situ hybridization, and molecular findings of these biopsies in conjunc ... | 2015 | 25321327 |
| ebv-mir-bart7-3p promotes the emt and metastasis of nasopharyngeal carcinoma cells by suppressing the tumor suppressor pten. | the epithelial-mesenchymal transition (emt) is crucial to cancer progression and metastasis. although multiple cellular mirnas have been identified to regulate the emt and metastasis in cancers, the role of viral mirnas in cancer progression remains largely unknown. nasopharyngeal carcinoma (npc) is an epstein-barr virus (ebv)-associated malignancy typically characterized by its early metastasis. in the present study, we have discovered the involvement of a viral mirna, ebv-mir-bart7-3p, in the ... | 2015 | 25347742 |
| function of interleukin-17 and -35 in the blood of patients with hepatitis b-related liver cirrhosis. | intrahepatic t helper (th)17 cytokine and serum interleukin (il)-17 levels in patients with hepatitis b are positively correlated with the progression of liver cirrhosis (lc). il-35 can significantly inhibit the differentiation of th17 cells and the synthesis of il-17. the present study aimed to investigate the function and expression of il-17 and il-35 in the blood of patients with hepatitis b‑related lc. the levels of il-17 and il-35 in the peripheral blood of 30 patients with chronic hepatiti ... | 2015 | 25323532 |
| relationship of intratumoural protein expression patterns to age and epstein-barr virus status in classical hodgkin lymphoma. | in western countries, the age distribution of hodgkin lymphoma (hl) follows a characteristic bimodal curve showing an early and a late peak at approximately 35 and 70 yr, respectively. furthermore, the presence of latent epstein-barr virus (ebv) genome in the hodgkin reed-sternberg cells, the tumour cell population of classical hl (chl), has been found to have adverse prognostic impact in elderly, but not in younger chl patients. we have characterised the protein expression in tumour tissue samp ... | 2015 | 25307790 |
| small molecule growth inhibitors of human oncogenic gammaherpesvirus infected b-cells. | epstein-barr virus (ebv) and kaposi's sarcoma-associated herpesvirus (kshv) are two human gammaherpesviruses associated with a broad spectrum of b-cell lymphomas, most acutely in immuno-compromised populations. however, there are no drugs which specifically target kshv or ebv-associated lymphomas. to identify small molecules which selectively inhibit the growth of ebv or kshv-associated b-cell lines, we performed a fluorescence based high-throughput screen on multiple stable gfp expressing virus ... | 2015 | 25306391 |
| risk factors for multiple sclerosis, neuromyelitis optica and transverse myelitis. | little is known about risk factors for neuromyelitis optica (nmo) or transverse myelitis (tm). | 2015 | 25305254 |
| methotrexate-related lymphoproliferative disorder arising in the gingiva of a patient with rheumatoid arthritis. | methotrexate (mtx) is the primary drug used in the management of rheumatoid arthritis (ra) and other immune-mediated inflammatory diseases. mtx is a strong immunosuppressive agent and has been reported to cause iatrogenic immunodeficiency-associated lymphoproliferative disorders (lpds). stomatitis caused by mtx-related cytotoxicity may occur, but gingival mtx-related lpds are rare. in this article we present a case of gingival mtx-related lpd in a 60-year-old male with ra. the local findings of ... | 2015 | 25302816 |
| immunomodulation effects of mesenchymal stromal cells on acute graft-versus-host disease after hematopoietic stem cell transplantation. | refractory acute graft-versus-host disease (agvhd) is a major cause of death after allogeneic hematopoietic stem cell transplantation. this study evaluated the immunomodulation effects of mesenchymal stromal cells (mscs) from bone marrow of a third-party donor for refractory agvhd. forty-seven patients with refractory agvhd were enrolled: 28 patients receiving msc and 19 patients without msc treatment. mscs were given at a median dose of 1 × 10(6) cells/kg weekly until patients got complete resp ... | 2015 | 25300866 |
| elevated antinuclear antibodies and altered anti-epstein-barr virus immune responses. | it has been shown that epstein-barr virus (ebv) is able to alter the immune response towards self-antigens and may enhance risk of autoimmune diseases such as systemic lupus erythematosus (sle) in genetically predisposed individuals. in this study, we evaluated the specific antibody immune response against ebv in patients with anti-nuclear autoantibodies (ana) in comparison with ana-negative healthy controls. for this purpose, 92 patients with an high anti-ana reactivity with or without concomit ... | 2015 | 25300805 |
| interferon regulatory factor 7 is involved in the growth of epstein-barr virus-transformed human b lymphocytes. | the cellular interferon (ifn) regulatory factor-7 (irf7) is closely associated with the epstein-barr virus (ebv)-mediated transformation of b lymphocytes in vitro and in vivo. however, the exact role of irf7 in viral transformation is not clear. we have found that knockdown of irf7 leads to growth inhibition of ebv-transformed cells, and restoration of irf7 by exogenous plasmid correlates with growth recovery of the viral transformed cells. in addition, irf7-knockdown cells have a lower prolifer ... | 2015 | 25300801 |
| down-regulation of lpa receptor 5 contributes to aberrant lpa signalling in ebv-associated nasopharyngeal carcinoma. | undifferentiated nasopharyngeal carcinoma (npc) is a highly metastatic disease that is consistently associated with epstein-barr virus (ebv) infection. in this study, we have investigated the contribution of lysophosphatidic acid (lpa) signalling to the pathogenesis of npc. here we demonstrate two distinct functional roles for lpa in npc. first, we show that lpa enhances the migration of npc cells and second, that it can inhibit the activity of ebv-specific cytotoxic t cells. focusing on the fir ... | 2015 | 25294670 |
| the epstein-barr virus and the pathogenesis of lymphoma. | since the discovery in 1964 of the epstein-barr virus (ebv) in african burkitt lymphoma, this virus has been associated with a remarkably diverse range of cancer types. because ebv persists in the b cells of the asymptomatic host, it can easily be envisaged how it contributes to the development of b-cell lymphomas. however, ebv is also found in other cancers, including t-cell/natural killer cell lymphomas and several epithelial malignancies. explaining the aetiological role of ebv is challenging ... | 2015 | 25294567 |
| association of epstein barr virus a73 gene polymorphism with nasopharyngeal carcinoma. | to study the association between epstein barr (eb) virus a73 gene polymorphism and nasopharyngeal carcinoma (npc) in a chinese han population. | 2015 | 25275219 |
| increased expression of interleukin (il)-35 and il-17, but not il-27, in gingival tissues with chronic periodontitis. | interleukin (il)-35 plays an important role in immune regulation through the suppression of effector t-cell populations, including t-helper 17 (th17) cells. although th17 cells and il-17 are involved in the pathogenesis of periodontitis, the level of il-35 in inflamed periodontal tissues is unclear. here, il-35, il-17, and il-27 production/expression in gingival crevicular fluid (gcf) and human gingival tissue were investigated. | 2015 | 25272982 |
| application of a commercial immunoblot to define ebv igg seroprofiles. | immunoblot (ib) techniques using different epstein-barr virus (ebv) antigens have been applied for detecting specific antibodies, making possible to obtain ebv seroprofiles in a single determination. the aim of this study was to evaluate a commercial ib for the detection of ebv-specific igg (euroimmun, lübeck, germany). | 2015 | 24687237 |
| primary effusion lymphoma with aberrant t-cell phenotype in an iatrogenically immunosuppressed renal transplant male: cytologic diagnosis in peritoneal fluid. | primary effusion lymphoma (pel) is an unusual class of non-hodgkin's lymphoma that develops in body cavities, without associated mass lesions. it has been linked to human herpes virus 8 (hhv-8), an etiological factor of kaposi's sarcoma. although pel is a b-cell lymphoma, the neoplastic cells are usually of the "null" phenotype by immunocytochemistry. the relative infrequency of this entity, the absence of wide casuistic allowing a better characterization, and its unfavorable outcome, strongly s ... | 2015 | 24644156 |
| design of a prognostic score model for nasopharyngeal carcinoma. | the purpose of this analysis was to create a prognostic score model for newly diagnosed nasopharyngeal carcinoma (npc) which has not been created before. | 2015 | 24599631 |
| [aplastic crisis due to parvovirus b19 and epstein-barr virus in a patient with hereditary spherocytosis]. | anemic syndrome in childhood requires a diagnosis and urgent treatment guided by systematic protocols that can avoid unnecessary additional testing. the case of a 4 year-old girl with fatigue and intermittent fever of 7 days duration, accompanied by abdominal pain is presented. she had regular general health status, with mucocutaneous jaundice, a grade iii/vi/iv murmur, and painful abdomen with hepatosplenomegaly. the blood analysis showed a hypo-regenerative anemia with increased ldh and indire ... | 2015 | 24629905 |
| plasmodium falciparum infection is associated with epstein-barr virus reactivation in pregnant women living in malaria holoendemic area of western kenya. | the role of plasmodium falciparum malaria in epstein-barr virus (ebv) transmission among infants early in life remain elusive. we hypothesized that infection with malaria during pregnancy could cause ebv reactivation leading to high ebv load in circulation, which could subsequently enhance early age of ebv infection. pregnant women in kisumu, where p. falciparum malaria is holoendemic, were actively followed monthly through antenatal visits (up to 4 per mother) and delivery. using real-time quan ... | 2015 | 24951129 |
| epstein-barr virus-associated methotrexate-induced accelerated rheumatoid nodulosis. | 2015 | 24710629 | |
| pkd1 is critical for epstein-barr virus lmp1-induced protection of malignant b cells from cell death induced by rituximab. | protein kinase d1 (pkd1 or pkcμ) is a serine/threonine kinase that contributes to malignant progression. although b and t cells express multiple pkcs, modulation of pkc in association with ebv has not been evaluated. in this study we examined the effects of pkd1 as a cellular target of ebv latent membrane protein-1 (lmp1) on the response of malignant b cells to rituximab and doxorubicin. lmp1 up-regulated pkd1 in malignant b cells but not in t cells. interestingly, lmp1 stabilized pkd1 protein t ... | 2015 | 24707946 |
| post-transplant lymphoproliferative disorder--case reports of three children with kidney transplant. | post-transplant lymphoproliferative disorder (ptld) is a heterogeneous group of diseases, characterized by abnormal lymphoid proliferation following transplantation. it is a disease of the immunosuppressed state, and its occurrence is mostly associated with the use of t-cell depleting agents, and also intensification of immunosuppressive regimens. in the majority of cases, ptld is a consequence of epstein-barr virus (ebv) infection and is a b-cell hyperplasia with cd-20 positive lymphocytes. the ... | 2015 | 24684038 |
| is gastric lymphoepithelioma-like carcinoma a special subtype of ebv-associated gastric carcinoma? new insight based on clinicopathological features and ebv genome polymorphisms. | gastric lymphoepithelioma-like carcinoma (lelc) is a rare entity that is closely associated with epstein-barr virus (ebv). however, the ebv latency pattern and genome polymorphisms in gastric lelc have not been systematically explored. | 2015 | 24771002 |
| severe post-transplant lymphoproliferative disorder after living donor liver transplantation. | post-transplant lymphoproliferative disorder (ptld) is a well-known complication after transplantation. a living donor liver transplantation was performed on a 31-year-old man for fulminant hepatitis. he again developed liver dysfunction after 7 months. he was diagnosed as having acute cellular rejection and the steroid pulse therapy introduced resulted in little improvement. he gradually developed a high fever and right axillary lymphadenopathy appeared. chest computed tomography (ct) was perfo ... | 2015 | 24750572 |
| epstein-barr virus and risk of non-hodgkin lymphoma in the cancer prevention study-ii and a meta-analysis of serologic studies. | epstein-barr virus (ebv) causes rare, malignant lymphomas. the role of ebv in other non-hodgkin lymphomas (nhls) remains unclear, but mildly reduced immune function could lead to reactivation of ebv and subsequent nhl. we examined the association between prospectively-collected plasma ebv antibodies and nhl risk in the cancer prevention study-ii (cps-ii) nutrition cohort and conducted a meta-analysis of our and published results. the cps-ii study included 225 nhl cases and 2:1 matched controls. ... | 2015 | 24831943 |
| epstein-barr virus--associated posttransplantation lymphoproliferative disorder with tacrolimus metabolism deterioration in infants after living-donor liver transplantation. | posttransplantation lymphoproliferative disorder (ptld) in infants after liver transplantation is strongly associated with tacrolimus (tac) administration and primary epstein-barr virus (ebv) transmission. | 2015 | 24846306 |
| epstein-barr virus-associated diffuse large b-cell lymphoma arising in atrial myxoma: a proposal for a modified therapeutic approach. | 2015 | 24794809 | |
| increased t-cell responses to epstein-barr virus with high viral load in patients with epstein-barr virus-positive diffuse large b-cell lymphoma. | the immunological status of patients with epstein-barr virus-positive diffuse large b-cell lymphoma (ebv+ dlbcl) without obvious immunodeficiency has not been elucidated. a multicenter prospective study was conducted to assess pretreatment t-cell responses to ebv, ebv-dna load and anti-ebv antibody in these patients. the proliferative and interferon (ifn)-γ-producing capacity of t-cells in response to autologous b-lymphoblastoid cell lines was determined using carboxyfluorescein diacetate succin ... | 2015 | 24975317 |
| drug reaction with eosinophilia and systemic symptoms during primary epstein-barr virus infection. | we report a drug reaction with eosinophilia and systemic symptoms case of primary epstein-barr virus (ebv) infection, in which the diagnosis was first confirmed by lymphocyte transformation tests (ltt). ltts were positive for cefditoren-pivoxil and acetaminophen. ltt, ebv load, and anti-ebv antibodies could allow early diagnosis of drug reaction with eosinophilia and systemic symptoms, which masquerades with the clinical features of infectious mononucleosis. | 2015 | 25074626 |
| prevalence of targetable oncogenic mutations and genomic alterations in epstein-barr virus-associated diffuse large b-cell lymphoma of the elderly. | epstein-barr virus (ebv)-associated diffuse large b-cell lymphoma (dlbcl) of the elderly constitutes a provisional clinicopathological entity in the current world health organization (who) classification and its genomic features remain sparsely characterized. we investigated a cohort of 26 cases of untreated de novo ebv-positive dlbcl of the elderly by high-resolution array-based comparative genomic profiling and fluorescence in situ hybridization (fish). moreover, we screened for activating mut ... | 2015 | 25030036 |
| stochastic simulation algorithm for gene regulatory networks with multiple binding sites. | promoters with multiple binding sites present a regulatory mechanism of several natural biological systems. it has been shown that such systems reflect a higher stability in comparison to the systems with small numbers of binding sites. regulatory mechanisms with multiple binding sites are therefore used more frequently in artificially designed biological systems in recent years. while the number of possible promoter states increases exponentially with the number of binding sites, it is extremel ... | 2015 | 25000485 |
| myoclonus as the main presentation of epstein-barr virus encephalitis. | 2015 | 25027162 | |
| genital ulcers: it is not always simplex …. | patients with vulval aphthae, also termed lipschütz ulcers, often present to genitourinary medicine clinics. typically, these ulcers present as acute, painful, vulval ulcers in young women and adolescents. the aetiology is unknown, and often these ulcers are accompanied by flu-like symptoms. previous case reports have linked such lesions to acute viral infections such as epstein-barr virus, cytomegalovirus and influenza a. we report the first case of influenza b virus and adenovirus infections a ... | 2015 | 24970475 |
| hla-a snps and amino acid variants are associated with nasopharyngeal carcinoma in malaysian chinese. | nasopharyngeal carcinoma (npc) arises from the mucosal epithelium of the nasopharynx and is constantly associated with epstein-barr virus type 1 (ebv-1) infection. we carried out a genome-wide association study (gwas) of 575,247 autosomal snps in 184 npc patients and 236 healthy controls of malaysian chinese ethnicity. potential association signals were replicated in a separate cohort of 260 npc patients and 245 healthy controls. we confirmed the association of hla-a to npc with the strongest si ... | 2015 | 24947555 |
| clinical features, genetics, and outcome of pediatric patients with hemophagocytic lymphohistiocytosis in korea: report of a nationwide survey from korea histiocytosis working party. | we analyzed a nationwide registry of pediatric patients with hemophagocytic lymphohistiocytosis (hlh) in korea to assess the clinical and genetic features and treatment outcomes in pediatric hlh. | 2015 | 24935083 |
| methotrexate-associated lymphoproliferative disorders of the tongue developing in patients with rheumatoid arthritis: a report of 2 cases and a review. | incidences of lymphoproliferative disorders (lpds) in patients with compromised immune systems associated with immunosuppressants such as methotrexate (mtx) administered for the treatment of rheumatoid arthritis (ra) are reportedly increasing. although extranodal lesions develop in half of the patients with mtx-associated lpds, only a few studies have reported on intraoral lesions. we evaluated 2 elderly women with mtx-associated lpds who had received mtx for the treatment of ra and presented wi ... | 2015 | 24927637 |
| ileal mass-like lesion induced by epstein-barr virus-associated hemophagocytic lymphohistiocytosis in a patient with aplastic anemia. | hemophagocytic lymphohistiocytosis (hlh) is a rare life-threatening hyperinflammatory syndrome characterized by activated macrophages engulfing erythrocytes, leukocytes, platelets, and their precursor cells in bone marrow, liver, spleen, or lymph nodes. we report a case of epstein-barr virus (ebv)-associated hlh unusually presenting as an ileal mass. a 23-year-old man presented initially with persistent fever unresponsive to antibiotics and pancytopenia. a bone marrow aspiration and biopsy were ... | 2015 | 25243347 |
| pediatric hodgkin lymphoma in a south indian regional cancer center: its immunomorphology, tumor-associated macrophages, and association with epstein-barr virus. | pediatric hodgkin lymphoma (hl) comprises approximately a fifth of all patients with hl in india. seventy-four cases of pediatric classical hodgkin lymphoma (chl) from a regional cancer center in southern india were analyzed on a tissue microarray (tma) for the stage of b-cell differentiation of the hodgkin/reed sternberg (hrs) cell by immunohistochemistry (ihc) using cd10, bcl6, mum1/irf4, and cd 138. fifty-two of seventy-four (70.3%) cases were of late germinal center/early post-germinal cente ... | 2015 | 25252151 |
| the role of epstein-barr virus in epithelial malignancies. | the close association of epstein-barr virus (ebv) infection with non-keratinizing nasopharyngeal carcinomas and a subset of gastric carcinomas suggests that ebv infection is a crucial event in these cancers. the difficulties encountered in infecting and transforming primary epithelial cells in experimental systems suggest that the role of ebv in epithelial malignancies is complex and multifactorial in nature. genetic alterations in the premalignant epithelium may support the establishment of lat ... | 2015 | 25251730 |
| occurrence and prognostic relevance of cd30 expression in post-transplant lymphoproliferative disorders. | post-transplant lymphoproliferative disorders (ptlds) are potentially fatal, often epstein-barr virus (ebv)-driven neoplasias developing in immunocompromised hosts. initial treatment usually consists of a reduction in immunosuppressive therapy and/or rituximab with or without chemotherapy. however, patients who relapse do poorly, and new treatment options are warranted. with the introduction of the immunoconjugate brentuximab vedotin, the cd30 antigen has become an effectively targetable molecul ... | 2015 | 25248878 |
| characterization of spontaneous malignant lymphomas in japanese macaques (macaca fuscata). | lymphomas are common spontaneous tumors in nonhuman primates but remain poorly characterized in japanese macaques (macaca fuscata). this study examined 5 cases of spontaneous malignant lymphoma in japanese macaques, focusing on the immunophenotypes and presence of simian lymphocryptoviruses, which are epstein-barr virus-related herpesviruses in nonhuman primates. the macaques with lymphoma were 5 to 28 years old, indicating that lymphomas develop over a wide age range. the common macroscopic fin ... | 2015 | 25248517 |
| deregulation of immune response genes in patients with epstein-barr virus-associated gastric cancer and outcomes. | patients with epstein-barr virus-associated gastric carcinoma (ebvagc) have a better prognosis than those with gastric cancer not associated with ebv infection (ebvngc). this is partly because ebv infection recruits lymphocytes, which infiltrate the tumor. a high degree of tumor heterogeneity is likely to be associated with poor response. we investigated differences in gene expression patterns between ebvagc and ebvngc. | 2015 | 25254613 |