Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| difficulties in producing antibodies to purified propionibacterium acnes exocellular enzymes. | attempts were made to produce antisera to purified preparations of propionibacterium acnes lipase, hyaluronate lyase and acid phosphatase in rabbits. antiserum to lipase (neutralizing titre i:32) was produced using conventional methods. lipase (30 micrograms) in freund's complete adjuvant (fca) was injected into multiple sites thrice at weekly intervals. antibody levels were boosted by i.v. injections of 30 micrograms in saline at 2-weekly intervals for 2 months. such regimes failed to raise ant ... | 1984 | 6691919 |
| the bacterial flora of the forehead and back of alaskan native villagers in summer and in winter. | the bacterial flora of the forehead and back of eskimo and indian villagers in arctic alaska was determined in midsummer and in winter (temperature -29 degrees to -46 degrees c). specimens collected by the wet swab method were transported overnight, chilled, to seattle in buffered diluent with triton x-100. control tests showed good survival of principal skin organisms with moderate or large initial populations and a disproportionately greater loss with an initial sparse population. results of t ... | 1984 | 6699430 |
| variably acid-fast bacteria in a fatal case of hodgkin's disease. | 1984 | 6703743 | |
| immunotherapy with biochemically dissociated fractions of propionibacterium acnes in a murine ovarian cancer model. | the antitumor effect of two strains of propionibacterium acnes (pai and paii) and chemically derived fractions from the whole bacterial cell were studied using a murine ovarian teratocarcinoma (mot) model. when injected i.p. in high doses (700 to 1400 micrograms/mouse), both strains produce survival of a significant proportion of tumor-bearing mice (30 to 90%). on a weight to weight basis, however, pai was significantly more effective than paii. pai and paii were extracted using pyridine, which ... | 1984 | 6713388 |
| the adverse effect of pregnancy on macrophage activation. | recently a remarkable decrease in the resistance to infection with listeria monocytogenes and toxoplasma gondii in pregnant mice was demonstrated. since activated macrophages are important in the resistance against these organisms, studies were performed to determine whether pregnancy has an adverse effect on the activation of macrophages and effector functions of these macrophages. peritoneal macrophages from normal pregnant and virgin mice or from pregnant and virgin mice previously injected w ... | 1984 | 6713543 |
| effect of pregnancy on augmentation of natural killer cell activity by corynebacterium parvum and toxoplasma gondii. | studies were performed to determine the effect of pregnancy on nk cell activity and the augmentation of nk cell activity which normally follows injection of killed c. parvum or live t. gondii. when compared to cells from virgin mice, peritoneal and splenic cells from unstimulated pregnant mice showed no significant difference in nk activity. in contrast, nk activity of peritoneal cells from pregnant mice that received c. parvum or t. gondii was significantly lower than that found in comparably t ... | 1984 | 6715884 |
| enhancement of thermal response of normal and malignant tissues by corynebacterium parvum. | further studies were carried out on the combined effects of corynebacterium parvum and hyperthermia on animal tissues and cultured chinese hamster ovary cells. experimental animals were c3hf/sed mice derived from our defined flora mouse colony. tumors were eighth-generation isotransplants of a spontaneous fibrosarcoma, fsa-ii. hyperthermia was given by immersing the mouse foot or culture flasks in the constant temperature water bath. present experiments include thermal enhancement of c. parvum a ... | 1984 | 6722772 |
| photoinactivation of propionibacterium acnes by near-ultraviolet light. | photodestruction of propionibacterium acnes was investigated by broad-band near-ultraviolet light. the inactivation of the bacteria was found to be oxygen dependent, and without o2 practically no photoinactivation occurred. d2o caused an increased inactivation (d10 = 5 kj/m2 in d2o as compared to d10 = 11 kj/m2 in normal water). decreased temperature during illumination increased the ability to form colonies. the results are compared with corresponding results for other types of cells and the de ... | 1984 | 6730638 |
| changes in the bacterial flora of the external ear canal from the wearing of occlusive equipment. | external otitis has been associated with wearing obstructive gear covering the earlobe and external ear canal. in this study we investigated the changes in the bacterial flora of the external ear canal after wearing rubber hoods. the bacterial flora of external ear canals surfaces was investigated in a group of 19 volunteers who wore rubber hoods for a period of 25 to 30 minutes while doing manual work. the protective effect of 2% acetic acid was tested by instilling it in the left ear of all pa ... | 1984 | 6738278 |
| comparative bacteriology of chronic blepharitis. | one hundred and fifteen patients with chronic blepharitis were compared with 47 normal controls. six clinically distinct groups of blepharitis were observed: staphylococcal; seborrhoeic, alone, with associated staphylococcal superinfection, meibomian seborrhoea, or secondary inflammation of the meibomian glands; and meibomian keratoconjunctivitis (mkc). staphylococcus aureus was isolated in appreciable frequency from the staphylococcal and the mixed staphylococcal/seborrhoeic groups in contrast ... | 1984 | 6743618 |
| acetic, propionic, and oleic acid as the possible factors influencing the predominant residence of some species of propionibacterium and coagulase-negative staphylococcus on normal human skin. | the minimum inhibitory concentration (mic) of acetic and propionic acid for resident bacteria on normal human skin, such as propionibacterium acnes and staphylococcus epidermidis, was 25 mg/ml or more at any ph tested (ph 5.5-6.8). while the mic of these acids for most of the transient bacteria was markedly decreased by lowering the ph of the media and at ph 5.5, the mean ph value of the normal human skin, the mic was 6.25 mg/ml or less. the mic of oleic acid for some strains of gram-positive tr ... | 1984 | 6744125 |
| [a case of spondylodiscitis caused by propionibacterium acnes and peptococcus constellatus]. | 1983 | 6612203 | |
| suppressive effects of corynebacterium parvum on primary and secondary antibody responses in mice. | the splenic plaque forming cell (pfc) response of mice to an intraperitoneal injection of sheep erythrocytes was severely depressed by prior treatment with corynebacterium parvum given four days beforehand by the same route. however, total antibody levels were less affected, and soon attained near normal titres. this implied that the effects of c. parvum were limited to the spleen, and that other tissues gave a substantial response during the period when the splenic response was suppressed. equa ... | 1983 | 6620257 |
| [antigenic relationship between the chemically-induced mouse bladder tumor and corynebacterium parvum]. | 1983 | 6620769 | |
| effects of the removal of the primary tumor and immunotherapy with corynebacterium parvum on metastatic tumor proliferation. | the effects of surgical intervention by removal of the primary focus, and the effectiveness of an immunomodulator, corynebacterium parvum (cp), on the proliferation of metastatic tumor tissue were investigated by following the postoperative changes in the 3h-thymidine labelling rate of metastatic tissue in an experimental model of metastasis in mice. in addition, the delayed type hypersensitivity reaction (dth) was studied to investigate the immune capacity of the host. the labelling rate of mic ... | 1983 | 6624533 |
| treatment of advanced ovarian malignancy with chemoimmunotherapy using autologous tumor and corynebacterium parvum. | fourteen patients with advanced ovarian epithelial carcinoma were treated with a combination of chemotherapy and immunotherapy. the chemotherapy consisted of either melphalan or a combination of adriamycin, cytoxan, and cisplatin. the immunotherapy consisted of the injection of autologous radiation-attenuated tumor and corynebacterium parvum. no significant toxicity occurred as a result of the immunotherapy, and there was no evidence of tumor growth at the sites of injection. the autologous tumo ... | 1983 | 6633998 |
| coparvax for malignant effusion? | 1983 | 6641514 | |
| organ distribution of tritium labeled corynebacterium parvum in mice. | 1983 | 6645221 | |
| [corynebacterium acnes osteitis. a case in a child]. | the authors report a case of corynebacterium acnes osteitis in an 11 year old girl, involving the upper of the right tibia. the lesion resembled a malignant tumour radiologically and tuberculosis histologically. scintigraphy revealed involvement of the seventh right rib. 3 months treatment with pristinamycin resulted in cure. | 1983 | 6646947 |
| protection of cattle against theileria annulata infection using corynebacterium parvum. | four groups of calves (a, b, c and d) each consisting of five calves were used for the present study. group a calves were given corynebacterium parvum alone. group b calves were inoculated with inactivated ground-up-tick supernate (guts) prepared from hyalomma anatolicum anatolicum infected with theileria annulata plus c. parvum. group c received only inactivated guts. all the surviving calves of groups a to c were exposed on day 45 post-inoculation to a lethal tick challenge along with suscepti ... | 1983 | 6649060 |
| growth of propionibacterium acnes strains on semisynthetic medium; antigenic polysaccharide production. | a semisynthetic medium, containing yeast extract as the only non defined component and glucose, glycerol, tween 80 and mineral salts, has been developed to grow the strains of propionibacterium acnes beck 2037, gerrath 2038 and vogel 2039, at a rate comparable to that of complex media. an average of 10(12) cells per 1 (equivalent to approximately 1.5 g/l dry weight) was usually achieved. these yields are appropriated for biochemical and immunological studies, e.g. cell wall preparation, polysacc ... | 1983 | 6649955 |
| the influence of endotoxin in vitro on hepatic macrophage lysosomal enzyme release in different rat models of hepatic injury. | since bacterial endotoxin is known to be involved in the pathogenesis of hepatic injury, the influence of endotoxin on lysosomal enzyme production by hepatic macrophages has been investigated. macrophages have been isolated from the livers of normal rats, from the livers of rats given stilboestrol subcutaneously 4 days previously and from the livers of rats given corynebacterium parvum intravenously 6 days previously. following isolation and overnight culture, the macrophages have been maintaine ... | 1983 | 6651924 |
| acute polyarthritis following the use of corynebacterium parvum vaccine (coparvax) for malignant pleural effusion. | a 77-year-old man with a malignant pleural effusion was treated by aspiration of fluid and injection of corynebacterium parvum vaccine for pleurodesis. within 24 hr he had developed a temperature and a neutropenia followed by an acute crippling polyarthritis of his hands and wrists which subsequently responded to oral steroids and non-steroidal antiinflammatory drugs. | 1983 | 6657546 |
| response of tumors to biologic modifiers and chemotherapeutic agents. | the use of the fanft model has facilitated clinical trials which are now beginning to have an impact on the therapy of human bladder tumors. we studied c. parvum and glucan immunotherapy of fanft tumors, and demonstrated the enhancement of tumor growth following glucan administration. weekly injections of cyclophosphamide (cy) retarded tumor growth and increased survival. combining c. parvum or glucan with cy resulted in greater tumor growth inhibition than cy alone. our data support the concept ... | 1983 | 6658848 |
| [mechanism of the antitumor immunity potentiated by anaerobic corynebacterium parvum]. | 1983 | 6662469 | |
| effects of oxygen concentration on biomass production, maximum specific growth rate and extracellular enzyme production by three species of cutaneous propionibacteria grown in continuous culture. | propionibacterium acnes, propionibacterium avidum and propionibacterium granulosum were grown in continuous culture at 0-100% air saturation using a semi-synthetic medium. maximum specific growth rate, biomass concentration and extracellular lipase, hyaluronate lyase and phosphatase activities were determined. all three species were capable of growth at 100% air saturation but at reduced growth rates. the presence of oxygen altered the production of extra-cellular enzymes. propionibacterium avid ... | 1983 | 6663280 |
| [etiological investigation of propionibacterium acnes variant isolated from children with kawasaki disease]. | 1983 | 6663741 | |
| [current trends in immunotherapy of tumors of the lung]. | 1983 | 6675558 | |
| [the effects of surgical intervention and removal of the primary tumor, and the effectiveness of corynebacterium parvum on metastatic tumor proliferation]. | the effects of surgical intervention and removal of the primary tumor, and the effectiveness of corynebacterium parvum (cp) on the proliferation of metastatic tumor tissue were investigated by using autoradiography to follow post-operative changes in the 3h-thymidine labelling rate of metastatic tissue in an experimental model of metastasis in mice. in addition, the delayed hypersensitivity reaction and the cytotoxicity (adcc, nk) of lung cells were studied, to investigate the immune capacity of ... | 1983 | 6676630 |
| changes in anatomical distribution of tumour lesions induced by platelet-active drugs. | to examine the effect of platelet-active drugs on the spread of blood-borne tumour cells, two murine tumours, sarcoma 180 (s-180) and tlx-5 lymphoma, were selected. following intravenous (iv) injection into cba mice the former elicited thrombocytopenia and formed discrete pulmonary tumours, whereas the latter failed to elicit thrombocytopenia and formed discrete tumours in all visceral organs examined except the lungs. s-180 cells were injected iv into mice pre-treated with ra233 (known to preve ... | 1983 | 6677619 |
| effect of corynebacterium parvum in the induction and course of mycoplasma arthritis of mice. | the effect of the immunostimulant c. parvum on the establishment and course of mycoplasma arthritis of mice was investigated. male swiss albino mice were injected intra-venously with m. arthritidis culture and intraperitoneally with c. parvum. it was shown that mice immunostimulated with c. parvum were significantly protected against the establishment of arthritis if the mycoplasma was given 9 days after the immunostimulant. however, when the arthritis was established c. parvum had no effect on ... | 1983 | 6678690 |
| in vitro activity of u-57930e against anaerobic bacteria and its comparison with clindamycin, ampicillin, carbenicillin and tetracycline. | the in vitro activity of u-57930e, a pipecolic acid amide of clindamycin, was compared with those of clindamycin, ampicillin, carbenicillin and tetracycline against 321 anaerobic clinical isolates. the mic (micrograms/ml) of u-57930e that inhibited 95% bacteroides fragilis, peptococcus prevotii, b. melaninogenicus and p. asaccharolyticus was 0.0625; 0.03125 for peptostreptococcus anaerobius, b. vulgatus, propionibacterium and peptococcus species. clindamycin, on the other hand, gave mic values o ... | 1983 | 6678915 |
| new therapeutic approaches to treatment of malignant gliomas: chemotherapy and immunotherapy. | 1983 | 6680086 | |
| non-specific immunization against bovine tropical theileriosis (theileria annulata) using killed corynebacterium parvum. | killed corynebacterium parvum was used as an adjuvant for the production of non-specific resistance against theileria annulata in cattle. groups of cross-bred (bos indicus x bos taurus) calves were administered c. parvum adjuvant subcutaneously and were then challenged with t. annulata-infected ticks on 45, 60 or 90 days later. the challenge caused mild reactions in the protected calves. none of the 10 immunized calves died due to theileriosis, whereas all three paris of susceptible control calv ... | 1983 | 6685397 |
| tuftsin stimulates the release of oxygen radicals and thromboxane from macrophages. | the physiologically occurring tetrapeptide, tuftsin (thr-lys-pro-arg), was examined for its effects on guinea pig peritoneal macrophages. adherent macrophages (møo) were exposed to tuftsin at concentrations ranging from 10(8) to 10(6) m, and the release of oxygen radicals and the arachidonic acid cyclo-oxygenation product, thromboxane b2 (txb2), was studied. tuftsin causes both albumin-elicited and c. parvum-activated møo to set free superoxide anion (o2) and hydrogen peroxide (h2o2). it also st ... | 1983 | 6687720 |
| solid tumor-derived target cell susceptibility to macrophages and natural killer/natural cytotoxic cells in the rat. | cytotoxic capacity of rat macrophages (m phi) and natural killer (nk)/natural cytotoxic cells (nc) against adherent growing, solid tumor-derived target cells was evaluated, modulating the activation status of effector cells and growth conditions of target cells. testing a panel of target cells, cytotoxicity of nk/nc and m phi was strikingly correlated so that besides of target-cell binding structures basic lysability seems to be of influence with respect to cytotoxicity rates. varying the in viv ... | 1983 | 6603412 |
| the role of immunotherapy in acute myelogenous leukemia. | the use of immunotherapy for acute myelogenous leukemia (aml) is controversial. twenty-four trials have been reported in which 1,491 patients with aml received various forms of immunotherapy, including bcg, methanol extract residue (mer) of bcg, or corynebacterium parvum. some patients were immunized with allogeneic or autologous leukemia blast cells. in only four of the 24 trials was a significant prolongation of remission reported. pooled data from all 24 studies were analyzed further. no stat ... | 1983 | 6577818 |
| chemotherapy and corynebacterium parvum for induction and maintenance of remission in acute myelogenous leukaemia--a controlled study. | 1983 | 6580265 | |
| intratumoral bcg and corynebacterium parvum therapy of canine mammary tumours before radical mastectomy. | in two parallel studies, bitches with mammary tumour received single intralesional injections of bcg (1 mg: 10(7) living bacteria) and corybacterium parvum (10(9) killed bacteria) (53 bitches) or c. parvum alone (129 bitches) at the same dosage. control groups received injections, following the same protocol, of 1 ml bcg suspension medium diluted in saline in the first study (51 bitches) or no injections at all (120 bitches in the second study). a block dissection, including mammary tumours, adj ... | 1983 | 6555059 |
| the growth and spontaneous dissemination of melanoma b16 and lewis lung tumour in two sub-strains of c57bl/6j mice treated with corynebacterium parvum and/or levamisole. | the effect of c. parvum and/or levamisole on tumour growth and spontaneous dissemination was tested in two tumour-host systems, melanoma b16 and llt in c57bl/6j mice. c. parvum inhibited the growth of llt and its dissemination to the lungs and the growth of b16 in females in one of the two sub-strains of mice used. levamisole stimulated the growth of b16 in females in one sub-strain and in both sexes in the other sub-strain of mice. the growth of llt was not influenced by levamisole but its diss ... | 1983 | 6546203 |
| studies of the extracellular proteolytic activity produced by propionibacterium acnes. | of several commercial media tested, trypticase soya both containing 0.4% (w/v) d-sorbitol was superior as a growth medium for the production of extracellular proteinase by propionibacterium acnes (strain p-37). extracellular proteinase, production of which was shown to be growth-associated by both batch and continuous culture studies, was partially purified by 70% (nh4)2so4 saturation. sephadex g-75 chromatography and ion exchange on deae-sephadex a-50. it was shown to be a heterogeneous mixture ... | 1983 | 6406421 |
| an evaluation of the antifungal effect of bifonazole on torulopsis glabrata and candida albicans under various in vitro test conditions. | 1-[(4-biphenylyl)-phenylmethyl]-1h-imidazole (bifonazole, bay h 4502, mycospor) showed in vitro significant inhibitory activity against torulopsis glabrata, candida albicans, pityrosporum ovale, corynebacterium acnes and staphylococcus epidermidis. the antifungal activity of bifonazole against t. glabrata and c. albicans varied with the in vitro test conditions. there was a tendency for minimal inhibitory concentrations to increase as fungal inoculum size was increased and as incubation time was ... | 1983 | 6409128 |
| kinetics of killing listeria monocytogenes by macrophages: rapid killing accompanying phagocytosis. | the kinetics of bactericidal activity of activated macrophages can be precisely described by a mathematical model in which phagocytosis, killing, digestion, and release of degraded bacterial material are considered to occur continuously. to gain a better understanding of these events, i have determined the period of time between first contact of bacteria with macrophages and the onset of killing. activated rat peritoneal macrophages were incubated for various times up to 15 min with listeria mon ... | 1983 | 6411918 |
| adjuvant immune stimulation with corynebacterium parvum during maintenance chemotherapy of acute myeloid leukemia. a prospective randomized study. | of 93 consecutively treated patients with acute myeloid leukemia 36 (39%) achieved complete remission (cr). thirty-five patients were randomized to receive either maintenance chemotherapy alone (c) or a combination of active nonspecific immunotherapy with corynebacterium parvum and chemotherapy (c + i). maintenance therapy was given monthly for 1 year or until relapse. the median survival time was 21 months for patients treated with chemotherapy alone, compared with 30 months for patients treate ... | 1983 | 6420046 |
| tumor-dependent resistance of rat peritoneal macrophages to herpes simplex virus. | by their position at sites of initial infection and their wide distribution in major organs of the body, macrophages may be decisive in determining the susceptibility or resistance of the host to virus infection. macrophage restriction of virus replication has been shown to be closely related to virus strains or virus types and to the age of the infected host. we report the effects of the development of a solid tumor in rats on intrinsic in vitro macrophage activity against herpes simplex virus ... | 1983 | 6299945 |
| induction of resistance to ectromelia virus infection by corynebacterium parvum in murine peritoneal macrophages. | an in vitro model has been developed to study the replication of ectromelia virus in murine macrophages (m phi). infection of mineral oil-elicited peritoneal m phi cultures with either the virulent (moscow) or attenuated (hampstead) strain of ectromelia virus led to productive infections. the kinetics of virus synthesis was similar to those seen following infection of murine fibroblasts. in contrast, peritoneal m phi s activated by intraperitoneal injection of corynebacterium parvum vaccine were ... | 1983 | 6300395 |
| inhibition of lymphocyte proliferation and antibody production in vitro by silica, talc, bentonite or corynebacterium parvum: involvement of peroxidative processes. | this study was undertaken to determine whether and by what means particles which induce granulomata in vivo can affect murine spleen lymphoproliferative and antibody responses in vitro. particles of silica, talc, bentonite or c. parvum cells inhibited lipopolysaccharide- or concanavalin a-stimulated proliferation and sheep red blood cell-induced antibody response in vitro. the inhibition required at least 48 hours exposure of the cells to the particles. the late onset of inhibition and its repro ... | 1983 | 6303797 |
| adherence of streptococci to cells infected with herpesvirus. | the attachment of streptococci and staphylococci to cells infected with influenza virus has been previously reported and has been correlated with the increased incidence of these bacterial infections during flu epidemics. the present work was initiated to determine whether infection with herpes simplex virus (hsv) might lead to preferential bacterial attachment. hep-2 cells were grown in monolayer and infected with hsv, type i or type ii. twenty-four hours later the cells were incubated with sus ... | 1983 | 6306535 |
| effects of ph on biomass, maximum specific growth rate and extracellular enzyme production by three species of cutaneous propionibacteria grown in continuous culture. | three cutaneous propionibacteria, propionibacterium acnes, propionibacterium avidum and propionibacterium granulosum, were grown in chemostats using semi-synthetic medium at various ph values. growth occurred between ph 4.5 and 7.5 for p. acnes and ph 5.0 and 8.0 for p. avidum and p. granulosum. the highest mumax was at ph 6.0 for the three species. maximum biomass production was obtained at ph 6.0 for p. acnes and p. avidum and at ph 7.5 for p. granulosum. extracellular enzyme production occurr ... | 1983 | 6311940 |
| improved survival after pneumococcus in splenectomized and nonsplenectomized mice with corynebacterium parvum. | splenectomy increases the susceptibility to infections with certain bacteria, particularly streptococcus pneumoniae. because the immunomodulator corynebacterium parvum expands the phagocytic cell compartment and enhances reticuloendothelial function, we tested the effect of c parvum in mice challenged with aerosolized pneumococci. mice splenectomized seven days before pneumococcal challenge and treated intraperitoneally with 700 micrograms of c parvum immediately after exposure were protected wh ... | 1983 | 6824432 |
| intraperitoneal immunotherapy of human ovarian carcinoma with corynebacterium parvum. | corynebacterium parvum has been administered i.p. to 14 patients with advanced ovarian cancer. two patients had responded completely to cytoreductive surgery and combination chemotherapy prior to immunotherapy, and one patient with residual disease had received only a single course of c. parvum due to i.p. catheter malfunction. among the 11 patients with residual disease evaluable for response, from three to eight i.p. treatments with c. parvum produced surgically confirmed tumor regression in f ... | 1983 | 6825108 |
| inefficacy of sc corynebacterium parvum in stage i malignant melanoma: preliminary results of a single-institution pilot study. | 1983 | 6825130 | |
| new group of prostaglandin-like compounds in p. acnes. | 1983 | 6826037 | |
| isolation, identification, and synthesis of 2,3-diamino-2,3-dideoxyglucuronic acid: a component of propionibacterium acnes cell wall polysaccharide. | a previously undescribed component of the cell wall polysaccharide of propionibacterium acnes, 2,3-diamino-2,3-dideoxyglucuronic acid, has been identified and synthesized. the component occurs to the extent of about 3 to 5% in the wall polysaccharides of p. acnes types i and ii and in propionibacterium avidum types i and ii; it also appears to be present, but in much smaller amounts, in the cell wall of propionibacterium granulosum. | 1983 | 6826525 |
| evidence for granulocyte-mediated macrophage activation after c. parvum immunization. | it has been previously demonstrated that at the peak of the peritoneal response to corynebacterium parvum (day 4), cytolytic macrophages can be characterized by the presence of intracellular bacteria. in the present study, the role of neutrophils in the activation of peritoneal macrophages by c. parvum was investigated. inflammatory neutrophils isolated 5 hr after ip administration of c. parvum were transferred to normal, syngeneic mice and the peritoneal macrophages of recipients harvested 4 da ... | 1983 | 6831566 |
| production, purification, and properties of a bacteriocin from staphylococcus aureus isolated from saliva. | staphylococci from samples of human saliva were isolated on staphylococcal-selective agar plates. these strains were tested for the inhibition of the growth of staphylococcus aureus fda209p. the frequency of inhibitory strains among all of the staphylococcal isolates was 5.2%. strain iys2, which formed the biggest inhibitory zone against the growth of the indicator strain, was used as the producer of bacteriocin. iys2 was identified to be s. aureus, based on its biological properties. the bacter ... | 1983 | 6832811 |
| enhancement of natural resistance to influenza virus in lipopolysaccharide-responsive and -nonresponsive mice by propionibacterium acnes. | lipopolysaccharide-responsive c3h/hen mice were rendered resistant to a mouse-adapted strain of influenza (aichi, h(3)n(2)) virus when propionibacterium acnes was given either intranasally or intraperitoneally several days before virus infection. the time of p. acnes treatment was important since no protection was demonstrated when this agent was given either on the same day as or several days after virus challenge. in contrast, lipopolysaccharide-nonresponsive c3h/hej mice were not protected wh ... | 1983 | 6832817 |
| role of reduced sulfur compounds in nutrition of propionibacterium acnes. | in a study of the nutritional requirements of propionibacterium acnes, acid hydrolyzed casein was shown to be the preferred nitrogen source in a glycerol-salts medium. of 22 individual amino acids tested, only cysteine supported growth in the glycerol-salts medium. this indicated a requirement not only for amino nitrogen but also for reduced sulfur. in the presence of an auxiliary nitrogen source, thioglycolate or thiosulfate could replace sulfur-containing amino acids. the apparent requirement ... | 1983 | 6833481 |
| susceptibility of propionibacterium acnes clinical isolates to 22 antimicrobial agents. | susceptibilities of 104 propionibacterium acnes isolates to each of 22 antimicrobial agents was evaluated by broth microdilution. these isolates were susceptible to all of the test agents except metronidazole. n-formimidoyl thienamycin, a penem coded sch 29482, and penicillin ranked first, second, and third, respectively, in activity and were significantly more active than other penicillins, cephalosporins, tetracyclines, clindamycin, or chloramphenicol. | 1983 | 6838191 |
| intrapleural corynebacterium parvum for malignant pleural effusions. | a pilot study of topical (intrapleural) treatment with corynebacterium parvum was carried out in 10 patients with malignant pleural effusions complicating primary or secondary neoplasms and necessitating frequent thoracocentesis for symptomatic relief. the method was aspiration of all intrapleural fluid except a small portion left for dilution, and then injection of 7 mg of a preparation of corynebacterium parvum suspended in 20 ml of normal saline solution. the treatment was repeated in each ca ... | 1983 | 6845257 |
| an unusual cause of bacterial meningitis in the elderly. propionibacterium acnes. | 1983 | 6847449 | |
| inhibition of hepatic drug metabolism in the rat after corynebacterium parvum treatment. | drug-metabolizing enzyme activities, cytochrome concentration, and protein content of hepatic microsomal preparations from adult, female sprague-dawley rats were examined at 1-, 3-, 6-, 10-, 14- and 17-day intervals after administration of a single intravenous injection of corynebacterium parvum (c. parvum) at a dose of 10 mg/m2. aniline hydroxylase (ah) activity, aminopyrine demethylase (apd) activity, and cytochrome p-450 concentration were reduced 20-50% on days 3-6 and, thereafter, gradually ... | 1983 | 6847717 |
| immunopotentiation of cell-mediated hypersensitivity by corynebacterium parvum (propionibacterium acnes). | we have investigated the activity of local corynebacterium parvum (propionibacterium acnes) as an immunopotentiator of allergic contact dermatitis (acd) and photo-acd in rodents. c. parvum given into the sensitization site, but not at a distance, increased the delayed-type hypersensitivity to the chemical allergen. an immunoadjuvant effect could be realized even when c. parvum was given several days after allergen; it was readily obtained in b cell-deficient mice. cyclophosphamide pretreatment h ... | 1983 | 6848475 |
| enhancement of tumor metastasis and suppression of natural killer cell activity by beta-estradiol treatment. | treatment of mice with 17 beta-estradiol leads to a selective inhibition of natural killer (nk) cell activity as measured by in vitro cytotoxicity against yac-1 lymphoma and uv-2237 fibrosarcoma target cells. activation of nk cells by polyinosinic-polycytidylic acid (poly i.c) and corynebacterium parvum also was impaired in beta-estradiol-treated mice, whereas activation of tumoricidal macrophages was uncompromised. the beta-estradiol-induced suppression of nk cell activity was associated with a ... | 1983 | 6848604 |
| enhanced fc receptor expression by a sub-population of murine intra-tumour macrophages following intravenous corynebacterium parvum therapy. | intravenous injection of corynebacterium parvum (c. parvum) 4 days after s.c. inoculation of 5 x 10(5) cells derived from the immunogenic fibrosarcoma fsa/r induced tumour growth inhibition over a period of 21 days in syngeneic c3h/buf mice. this was not accompanied by a change in the proportions of host cells within the tumour, but the activation state of tumour-infiltrating macrophages was increased following c. parvum therapy. two macrophage subpopulations were identified in fsa/r tumours aft ... | 1983 | 6860547 |
| propionibacterium shunt nephritis in two adolescents with medulloblastoma. | the anaerobic diphtheroid propionibacterium acnes was identified as the organism responsible for "shunt" nephritis in two adolescents with ventriculoatrial shunts inserted previously for the management of medulloblastoma. only three cases of "shunt" nephritis secondary to infection with this common skin commensal organism are known to have been reported. the rarity of such reports may be related to the lack of good anaerobic laboratories, the length of time necessary for cultures to show growth, ... | 1983 | 6861076 |
| protection of mice against influenza virus infection: enhancement of nonspecific cellular responses by corynebacterium parvum. | groups of c57bl/6j, balb/c, balb/c, nu+/nu+ mice, inoculated intranasally with corynebacterium parvum (350 micrograms/mouse) were protected from death by an otherwise lethal dose of influenza virus, a/wsn (h1n1) inoculated 3 days later. the lungs of c. parvum-treated, virus-infected c57bl/6j, balb/c, or balb/c nu+/nu+ mice contained significantly less infectious virus than did controls, and this reduction was apparent as soon as 24 hr after virus inoculation. the maximum protective effect correl ... | 1983 | 6861206 |
| bacteriological study in chronic maxillary sinusitis. | the bacterial findings of 73 maxillary sinuses in 48 patients with chronic maxillary sinusitis, together with 7 non-inflamed sinuses, are reported. employing an intraoperative technique and simultaneous collection of 3 different types of specimens in the present investigation made possible comparison of their bacterial characteristics. the results indicated that intraoperative culture of antral mucosa seems to provide the most reliable finding of bacterial flora in chronic maxillary sinusitis. t ... | 1983 | 6865629 |
| leishmania tropica major in mice: vaccination against cutaneous leishmaniasis in mice of high genetic susceptibility. | balb/c and balb/c.h-2b mice are genetically susceptible to development of persistent and severe disease following cutaneous injection of promastigotes of the protozoan parasite, leishmania tropica major, whereas c57bl/6 are relatively resistant. resistance in c57bl/6 can be further increased by intraperitoneal injection of living, but not killed, promastigotes prior to cutaneous challenge. severely diseased balb/c mice can show resistance to development of a second cutaneous lesion but apparentl ... | 1983 | 6870673 |
| platelet activating factor (paf) induces the oxidative burst in macrophages. | the response of guinea pig peritoneal macrophages to platelet activating factor (1-o-octadecyl-2-acetyl-sn-glycero-3-phosphoryl-choline) was examined. in corynebacterium parvum induced macrophages, platelet activating factor, over a wide dose range (3.8 x 10(-5) to 3.8 x 10(-9)m) triggered the oxidative burst as indicated by increased luminol-dependent chemiluminescence and hydrogen peroxide release into culture supernatants. this effect of paf was inhibited by superoxide dismutase and catalase. ... | 1983 | 6874164 |
| augmentation of nk activity by corynebacterium parvum fractions in vivo and in vitro. | biochemically modified whole cell preparations and derived fractions of corynebacterium parvum (c. parvum) were evaluated for the ability to augment natural killer cell cytoxicity in vivo and in vitro in rats. unfractionated c. parvum enhanced peritoneal cell (pc) nk activity in a dose dependent fashion. this activity appeared to be enriched in insoluble light residue material obtained from hot phenol water extraction. enhancement of pc cytotoxicity was significantly greater at all time points t ... | 1983 | 6874167 |
| new antibiotic, isohematinic acid. ii. physico-chemical properties, structural elucidation and biological activities. | physico-chemical characterization of isohematinic acid revealed that this antibiotic has a succinimide nucleus. from elemental analysis, the molecular formula of isohematinic acid was determined to be c8h9no4. isohematinic acid showed weak antimicrobial activities against anaerobic bacteria, such as bacteroides fragilis and propionibacterium acnes. | 1983 | 6874567 |
| the effect of benzoyl peroxide on cutaneous micro-organisms in vitro. | the survival curves of cutaneous micro-organisms in the presence of benzoyl peroxide were investigated. all the curves exhibited a shoulder prior to exponential cell death. benzoyl peroxide was lethal to the cutaneous organisms tested and they varied in sensitivity increasing as follows: propionibacterium acnes, staphylococcus capitis, staph. epidermidis, staph. hominis, prop. avidum, prop. granulosum and pityrosporum ovale. | 1983 | 6874624 |
| [treatment of resistant pulmonary tuberculosis using chemotherapy and immunomodulators]. | 1983 | 6879325 | |
| oxygen and serum complement in phagocytosis and killing of propionibacterium acnes. | phagocytosis and killing of propionibacterium acnes by human peripheral blood leukocytes were promoted by normal human serum and by serum depleted of immunoglobulin g and m. serum that had been heat-inactivated, depleted of complement component c3, or depleted of c4 and factor b, did not promote phagocytosis or killing. depletion of complement-component c4 or factor b from normal human serum did not impair its capacity to promote phagocytosis and killing of p. acnes. these results indicate that ... | 1983 | 6880750 |
| mechanisms of the potentiation of specific antitumor immunity by intratumor injection of corynebacterium parvum. | meth a fibrosarcoma-bearing balb/c mice given intratumoral injections of 0.5 mg of corynebacterium parvum showed a highly and tumor-specific transplantation antigen specifically potentiated concomitant immunity to a subsequent tumor challenge. this potentiated antitumor immunity could be locally transferred in the winn assay to normal recipients with whole draining lymph node cells from the tumor-bearing mice, but the potentiated effect disappeared when adherent cells were removed from these cel ... | 1983 | 6883325 |
| intracavitary corynebacterium parvum for treatment of malignant effusions. | intracavitary instillation of corynebacterium parvum was used to treat recurrent malignant effusions in 15 patients. eleven patients were treated for ascites, and four patients were treated for pleural effusion. six patients (40%) had good response with no recurrence of effusions up to 3 months after treatment. three patients responded but died before criteria for complete response could be fulfilled. six patients were judged to have poor response, either because of death from tumor burden befor ... | 1983 | 6884832 |
| differential effects of chronic monocyte depletion on macrophage populations. | the administration of the bone-seeking isotope, 89sr, to mice results in severe monocytopenia without any apparent effect on the numbers of resident peritoneal macrophages (mphi). an explanation for this dichotomy was sought by determining whether the residual blood monocytes were still an effective source of mphi after 89sr treatment. stem cell enumeration showed that a 90% fall in bone marrow macrophage colony-forming cells after 89sr was accompanied by a 10-fold rise in splenic m-cfc. splenec ... | 1983 | 6887784 |
| role of natural killer cells in host defense against cancer metastasis. | 1983 | 6382510 | |
| propionibacteria in patients with acne vulgaris and in healthy persons. | a total of 375 anaerobic and microaerophilic coryneform rods, isolated from the pilosebaceous ducts of 26 healthy persons (71 strains) and from comedones (93 strains), pustules (107 strains), and the unaffected skin (104 strains) of 36 acne patients were classified according to the species key in bergey's manual, the biotyping scheme of pulverer and ko, the serotyping schedule of höffer et al., and the phage typing schedule of jong et al. the statistical evaluation demonstrated certain differenc ... | 1983 | 6223602 |
| teichomycin: in-vitro and in-vivo evaluation in comparison with other antibiotics. | teichomycin, a new glycopeptide antibiotic with a spectrum of activity similar to that of vancomycin, was highly active against staphylococci, streptococci and gram-positive anaerobes (propionibacterium acnes, clostridium perfringens and cl. difficile). ninety per cent of the staphylococcus aureus and streptococcal strains, including enterococci, were inhibited by 0.4 mg/l; 90% of staph. epidermidis strains were susceptible to 1.6 mg/l. vancomycin was less active than teichomycin against all cli ... | 1983 | 6223907 |
| resistance of propionibacteria to antibiotics used in the treatment of acne. | strains of propionibacteria resistant to clindamycin or clindamycin and erythromycin were isolated from four patients with acne, three of whom were receiving clindamycin. four strains of p. acnes and one of p. granulosum with moderate levels of tetracycline resistance were isolated from 25 patients with acne being treated with tetracycline. a similar increase in tetracycline resistance was achieved by training sensitive strains in vitro. p. acnes was sensitive to sulphonamide and trimethoprim bu ... | 1983 | 6224016 |
| what causes acne? | 1983 | 6224128 | |
| [acne: pathogenesis and therapy]. | 1983 | 6225028 | |
| inhibition of natural killer cell activity by a soluble substance released by rat peritoneal cells. | we describe here a soluble substance released by nonadherent cells from the peritoneal cavity of w/fu rats that markedly inhibits the activity of mouse, rat, and human natural killer (nk) cells. the nk-inhibiting substance (nk-is) has low molecular weight (less than 1000), is heat resistant (100 degrees for 15 min), and is insensitive to nonspecific proteases. nk-is is produced in the presence of indomethacin (1 to 10 micrograms/ml), suggesting it is not prostaglandin. the inhibitory effect was ... | 1983 | 6339046 |
| effects of treatment with muramyl dipeptide on resistance to mycobacterium leprae and mycobacterium marinum infection in mice. | studies were carried out to determine whether treatment of mice with the synthetic adjuvant muramyl dipeptide (mdp) afforded resistance to infection with mycobacterium leprae or m. marinum in mice. regardless of the timing, dose, or route of administration, there was no evidence that treatment with mdp or 3 of its analogs (desmdp, abumdp, valmdp) enhanced resistance to food pad infection with m. leprae or m. marinum. in parallel studies, systemic treatment with propionibacterium acnes failed to ... | 1983 | 6343295 |
| comparison between natural reactivity (nr) against candida albicans and natural killer (nk) activity against yac-1 tumour cells. | cytotoxic activity against candida albicans was measured in vitro in a 4-h 51cr-release assay. the levels of reactivity correlated well with the number of polymorphonuclear cells in the effector population, being augmented by the enrichment of polymorphonuclear granulocytes. to exclude the possible role of contaminating natural killer cells, natural killer activity against tumour cells was compared with natural reactivity against candida albicans in vitro. the findings indicate that there are ma ... | 1983 | 6345429 |
| cellular suppression of murine adcc and nk activities induced by corynebacterium parvum. | administration of a single dose of c. parvum (cp) induces depression of splenic nk activity in mice after a lag period of 3-5 days and this depression lasts about 2 weeks. the depressed levels of nk activity noted in this study depended on time of cp administration and were associated with the induction of suppressor cell activity. neonatally thymectomized or sublethally irradiated mice had unimpaired ability to generate suppressor cells following cp treatment. depletion of adherent/phagocytic c ... | 1983 | 6347362 |
| increased susceptibility to escherichia coli infection in mice pretreated with corynebacterium parvum. | the contribution of activated macrophages to protection against escherichia coli was studied in mice treated intravenously with corynebacterium parvum 7 days before infection. c. parvum-treated mice showed increased phagocytic activity and enhanced resistance to listeria infection. in contrast, these mice showed increased susceptibility to a subsequent challenge with e. coli that correlated closely with a reduction in the ld50 of lipopolysaccharide (lps) in these mice. the peritoneal macrophages ... | 1983 | 6348489 |
| membrane changes in murine macrophages after in-vivo stimulation and activation. | the expression of various receptors and other surface determinants on resident, glycogen-and corynebacterium parvum- elicited mouse peritoneal macrophages has been described. macrophage fc (igg2b) receptors and i-a antigens were slightly increased after stimulation and a more marked increase was shown after activation with c. parvum. complement receptor expression was enhanced after stimulation but was markedly reduced after activation. c. parvum-elicited macrophages, and to a lesser extent glyc ... | 1983 | 6350168 |
| [immunotherapy of breast cancer (review of foreign literature)]. | 1983 | 6351428 | |
| anemia and thrombocytopenia from corynebacterium parvum-stimulated resistance against malaria, trypanosomiasis, and babesiosis. | nonspecific immunity (nsi) was manifested in rats injected intravenously with killed corynebacterium parvum and challenged with trypanosoma lewisi, plasmodium chabaudi, or babesia rodhaini. the nsi became evident some 5 days after infection as a suppressed parasitemia, a more rapid recovery from patent infection and as enhanced survival among rats infected with b. rodhaini. the c. parvum injections produced anemia and thrombocytopenia with splenomegaly and signs of glomerulonephritis in rats. th ... | 1983 | 6355427 |
| production of lymphocyte activating factor in vivo. | mice injected with propionibacterium acnes, when challenged with lipopolysaccharide release a range of soluble mediators into their serum. included among these is lymphocyte activating factor (laf, interleukin-1). the release of laf in vivo was detected only when serum samples were assayed at high dilution because inhibitors of its activity in vitro were also present. the kinetics of release of laf in vivo after injection of p. acnes was dependent on the mouse strain used. laf was also detected ... | 1983 | 6360852 |
| a phase-ii trial of corynebacterium parvum as adjuvant to surgery in the treatment of operable lung cancer. | a phase-ii randomized trial has been undertaken in 49 patients with operable lung cancer, to determine the effect of a single iv infusion of killed c. parvum vaccine as an adjuvant to surgery. the number of patients was insufficient to provide a decisive result, but analysis 6 years after the last patient was admitted shows that the adjuvant therapy certainly did not shorten, and may well have prolonged, survival. of the patients with squamous cell carcinoma who were alive 1 year after operation ... | 1983 | 6362846 |
| regulation of natural killer cell activation: implementation for the control of tumor metastasis. | the cellular interactions that regulate natural killer (nk) cell-mediated cytotoxicity and antimetastatic activity following treatment with biological response modifiers (brm) were studied. the transient activation of nk cells by a single injection of corynebacterium parvum is followed by a refractory period during which a second injection of brm fails to stimulate the already depressed nk cell activity. during this hyporesponsive period, the in vivo nk cell-dependent brm-induced antimetastatic ... | 1983 | 6235447 |
| anti-p. acnes antibody in comedonal extracts. | extracts of comedonal material obtained from patients with acne vulgaris were analyzed for albumin, igg, igm, iga, and anti-propionibacterium acnes antibodies using immunodiffusion and anti-immunoglobulin hemagglutination tests. extracts were obtained from comedones of patients with (1) comedonal, (2) papulopustular, (3) nodular-cystic, (4) "burned out" acne, (5) patients under oral tetracycline treatment, and (6) with pustules. in all comedonal extracts analyzed, albumin and igg (ratio approxim ... | 1983 | 6217259 |
| propionibacterium acnes resistance to antibiotics in acne patients. | the minimal inhibitory concentration (mic) of propionibacterium acnes in seventy-five acne patients receiving long-term antibiotic therapy demonstrated the emergence of resistant strains. the mean mic in thirty-three patients receiving long-term tetracycline was four to five times higher than that found in control groups of acne patients not receiving antibiotic therapy and controls free of acne. the average mic for erythromycin was more than 100 times higher in those receiving long-term antibio ... | 1983 | 6219134 |
| role of corynebacterium parvum in the activation of peritoneal macrophages. ii. identification of distinguishable anti-tumor activities by macrophage subpopulations. | two different mechanisms of murine macrophage (mp) antitumor activity are described in this report. c. parvum-activated peritoneal mps were tested for cytotoxic and cytostatic activity 4 days after ip immunization. cytotoxic activity could be distinguished from cytostatic activity using two different assay protocols. when mps were separated by 1g velocity sedimentation, cytotoxic mps were confined to high velocity fractions. in contrast, cytostatic mps were found in cell fractions with velocitie ... | 1983 | 6219754 |
| effects of treatment with erythromycin 1.5 percent topical solution or clindamycin phosphate 1.0 percent topical solution on p. acnes counts and free fatty acid levels. | twenty healthy subjects (7 men and 13 women) with average baseline p. acnes counts equal to or greater than 1.0 x 10(5) were treated twice a day for eleven days in a randomized, double-blind study with either erythromycin 1.5 percent topical solution or clindamycin phosphate 1.0 percent topical solution. p. acnes counts and free fatty acid (ffa) measurements were performed before treatment, and on days 4 and 11 of treatment. statistically significant reductions in p. acnes counts were produced i ... | 1983 | 6220870 |
| comparative activity of benzoyl peroxide and hexachlorophene. in vivo studies against propionibacterium acnes in humans. | the bactericidal effects of benzoyl peroxide (5% lotion) and hexachlorophene (3% colloidal suspension) against propionibacterium acnes were compared in nine healthy college students who had the microbiological and skin lipid characteristics typical of acne vulgaris, but no active lesions. each of the two medications was applied twice daily, to opposite sides of the face, for four consecutive weeks. hexachlorophene was effective against surface aerobes but only slightly active against p acnes. it ... | 1983 | 6222704 |