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molecular recombination in t4 bacteriophage deoxyribonucleic acid. ii. single-strand breaks and exposure of uncomplemented areas as a prerequisite for recombination.deoxyribonucleic acid (dna) from several "dna-deficient" amber mutants was observed to be either nicked (amber 22, 82, 122, and wild type) or cut (amber 453) after injection into a nonpermissive host. this effect was inhibited by chloramphenicol (cm), indicating that it is due to phage-induced enzymes. although most of the mutants tested for replication in a density-label system were in fact dna-deficient (amber 22, 82, 122), one (amber 81) was found to replicate almost identically to the wild t ...19674912244
recombination in bacteriophage t4. 19675582804
increased heterozygote frequency in certain regions of the t4-chromosome. 19675586530
damage to deoxyribose molecules and to u-gene reactivation in uv-irradiated 5-bromouracil-dna of phage t4 bor as influenced by cysteamine. 19675586533
exclusion of rna bacteriophages and interference with their rna replication by bacteriophage t4. 19675586930
molecular recombination in t4 bacteriophage deoxyribonucleic acid. i. tertiary structure of early replicative and recombining deoxyribonucleic acid.a replicative hybrid resulting from the infection of heavy (substituted with 5-bromodeoxyuridine) bacteria with light (not substituted with 5-bromodeoxyuridine) radioactive bacteriophage was isolated from a cscl density gradient. sedimentation studies indicate that 60% of the deoxyribonucleic acid (dna) behaves as if it were in units more than four times as large as an intact reference molecule. under the electron microscope, hybrid molecules appeared tangled, showed puffs and loops, occupied a ...19675621474
further studies on the mutation with glucose oxime: the reaction of the oxime with t4 phage and nucleic acids. 19675622070
properties of r mutants of bacteriophage t4 photodynamically induced in the presence of thiopyronin and psoralen.about 4 x 10(-4)r mutants were induced per lethal hit, a frequency characteristic of weak mutagens. collections of mutants produced in the presence of either dye were indistinguishable in most of their properties. the rii mutants differed sharply from spontaneous mutants in their mutational spectra (fine scale map distribution) and their reversion responses to specific mutagens. few or none of the induced mutants were induced to revert with proflavine (sign mutants; reading frame shift mutants). ...19675623962
differential effect of polyamines on t4 morphogenesis.the 5-fluorouracil (5 fu) technique for the phenotypic reversion of amber mutants was used to demonstrate that under certain circumstances, in the presence of putrescine or spermidine, early mutants have an enhanced response to 5 fu, whereas late mutants have a delayed response. bacteria infected by t4d wild-type bacteriophage did not produce phage in the presence of high putrescine concentrations. pulse treatments with putrescine showed that the production of lysozyme depends on a putrescine-se ...19675623974
selective gene transcription in bacteriophage t4 by putrescine.messenger ribonucleic acid (mrna) preparations from t4-infected cells formed in the presence or absence of putrescine have been characterized and compared. hybrid competition experiments indicate that these mrna molecules are derived from distinct genetic loci. the results are consistent with the hypothesis that putrescine might control differential transcription of the phage genome during morphogenesis. the data are also in accord with previously observed changes in the population of mrna forme ...19675623975
partial isolation of an riib segment of t4 dna by hybridization with homologous rna. 19675231397
early intracellular events in the replication of t4 phage dna. 3. random utilization of phage-coded enzymes by simultaneously infecting phage. 19675231405
the length of the homologous pairing region for genetic recombination in bacteriophage t4. 19675233853
enzymatic breakage and joining of deoxyribonucleic acid. ii. the structural gene for polynucleotide ligase in bacteriophage t4. 19675234326
in vitro synthesis of t4 lysozyme by suppression of amber mutations. 19675237496
expression of genes in incomplete t4 genomes. 19675336879
linkage of t4 genes controlling a series of steps in pyrimidine biosynthesis. 19675336881
the infection of escherichia coli by t2 and t4 bacteriophages as seen in the electron microscope. i. attachment and penetration. 19675337968
the infection of escherichia coli by t2 and t4 bacteriophages as seen in the electron microscope. ii. structure and function of the baseplate. 19675337969
the enzymology of virus-infected bacteria. x. a biochemical-genetic study of the deoxynucleotide kinase induced by wild type and amber mutants of phage t4. 19675338507
inhibition of growth of rii mutants of bacteriophage t4 by immunity substance of bacteriophage lambda. 19675340188
ribosome-bound messenger rna in t4-infected bacteria. 19675340468
enzymatic breakage and joining of deoxyribonucleic acid, i. repair of single-strand breaks in dna by an enzyme system from escherichia coli infected with t4 bacteriophage. 19675340583
isolation and preliminary characterization of t4 mutants with nonglucosylated dna. 19675340730
characteristics of mutations appearing spontaneously in extracellular particles of bacteriophage t4. 19675341474
inhibition of bacteriophage t4 deoxyribonucleic acid maturation by actinomycin d. the accumulation of "replicating deoxyribonucleic acid". 19676016329
a determination of mutagen specificity in bacteria using nonsense mutants of bacteriophage t4. 19676029739
genotypic reversion by hydroxylamine: the orientation of guanine-hydroxymethylcytosine at mutated sites in phage t4 rii. 19676029979
on the mode of action of a potent carcinogen, 4-hydroxylaminoquinoline 1-oxide on bacteriophage t4. 19676033784
structure of the sheath of bacteriophage t4. i. structure of the contracted sheath and polysheath. 19676034098
structure of the sheath of bacteriophage t4. ii. rearrangement of the sheath subunits during contraction. 19676034099
the absolute sign of certain phase-shift mutants in bacteriophage t4. 19676034781
a mutant of bacteriophage t4 defective in alpha-glucosyl transferase. 19676035109
further evidence for polarity mutations in bacteriophage t4. 19676038426
the bar-properties, in particular glucsylation of deoxyribonucleic acid, in crosses of bacteriophages t2 and t4. 19676042715
photodynamic inactivation of free and vegatative bacteriophage t4. 19676048293
sequence similarities between hen egg-white and t4 phage lysozymes. 19676050212
polynucleotide cellulose as a substrate for a polynucleotide ligase induced by phage t4. 19676052493
mapping of deletions in a non-essential region of the phage t4 genome. 19676052642
[study of the distribution and metabolism of t4-i 125 and of t3-i 125 in the rat]. 19676056675
polarized exclusion of bacteriophage t2 in crosses with t4. 19676062375
on the specificity of bacteriophage-induced hydroxymethylcytosine glucosyltransferases. ii. specificities of hydroxymethylcytosine alphaand beta-glucosyltransferases induced by bacteriophage t4. 19676078540
[new technic for the study of the metabolism of thyroid hormones (t4-125-t3-131). experimental and clinical data]. 19676081817
streptomycin suppression of ambivalent phage mutations.phenotypic repair by streptomycin has been studied in amber mutants of phage t4 on su- strains, as has the interference of smr mutations with amber suppressors. the repair seems not to be specific; however a temporal specificity of streptomycin action has been demonstrated by means of pulse experiments. the dependence of the efficiency of suppression upon experimental condition is also reported.196718614055
effect of phage on amino acid activation.infection of escherichia coli np2 with t-even phage strains is known to cause the appearance of a new valyl trna synthetase activity. in the present work mutant hosts possessing altered activating enzymes for phenylalanine, glycine, or histidine were employed to detect possible phage-induced modifications in the translating systems for these amino acids. the results establish that t4 has an absolute requirement for the phenylalanyl trna synthetase of its host, probably in an unmodified form, and ...196718614089
adsorption of viruses on activated carbon. equilibriums and kinetics of the attachment of escherichia coli bacteriophage t4 on activated carbon. 196722148337
chromosome structure in phage t4, iii. terminal redundancy and length determination. 196716591467
total and free triiodothyronine in human serum.a reliable method has been developed for the determination of total serum t3, dialyzable fraction (dft3), and absolute concentration of free t3 (aft3). total t3 values (mean +/- sd) were: healthy euthyroid subjects, 0.33 +/- 0.07 mug per 100 ml; hyperthyroid patients, 0.71 +/- 0.1 mug per 100 ml; hypothyroid, 0.10 +/- 0.03 mug per 100 ml. values (mean +/- sd) for dft3 in these groups were 0.46 +/- 0.14%, 0.78 +/- 0.17%, and 0.16 +/- 0.08%, respectively. calculated values for aft3 were: 1.51 +/- ...196716695923
deoxyribonucleic acid synthesis in escherichia coli infected with some deoxyribonucleic acid polymerase-less mutants of bacteriophage t4. 19664285470
bacteriophage-induced functions in escherichia coli k (lambda) infected with rii mutants of bacteriophage t4.rutberg, blanka (karolinska institutet, stockholm, sweden), and lars rutberg. bacteriophage-induced functions in escherichia coli k(lambda) infected with rii mutants of bacteriophage t4. j. bacteriol. 91:76-80. 1966.-when escherichia coli k(lambda) was infected with rii mutants of phage t4, deoxycytidine triphosphatase, one of the phage-induced early enzymes, was produced at initially the same rate as in r(+)-infected cells. deoxyribonuclease activity was one-third to one-half of that of r(+)-in ...19664285536
mutants of bacteriophage t4 unable to cause breakdown of host dna. 19664287490
ultraviolet sensitivity and functional capacity in bacteriophage t4. 19664291093
evidence for a dual role for the bacteriophage t4-induced deoxycytidine triphosphate nucleotidohydrolase. 19664291203
the production of phage structural proteins in single cells of escherichia coli infected with phage t4. 19664222685
immunochemical studies on bacteriophage dna. vi. renaturation of t4 dna. 19665912032
acridine orange-sensitized photoinactivation of t4 bacteriophage. i. parameters affecting phage sensitivity to visible light. 19665922453
acridine orange-sensitized photoinactivation of t4 bacteriophage. ii. genetic studies with photoinactivated phage. 19665922454
in vivo stability of bacteriophage t4 messenger ribonucleic acid.cohen, paul s. (st. jude children's research hospital, memphis, tenn.), and herbert l. ennis. in vivo stability of bacteriophage t4 messenger ribonucleic acid. j. bacteriol. 92:1345-1350. 1966.-a mutant of escherichia coli b, defective in its transport and concentration of k(+), synthesizes ribonucleic acid (rna) without the simultaneous synthesis of protein when depleted of this cation. the mutant was used to study the in vivo stability of phage t4 messenger rna (mrna) in the presence and absen ...19665924268
inactivation of poly-dl-alanyl bacteriophage t4 with antisera specific toward poly-dl-alanine. 19665925704
expression of the rii function by native transforming dna of bacteriophage t4. 19665929245
ultraviolet mutagenesis in bacteriophage t-4. i. irradiation of extracellular phage particles.drake, john w. (university of illinois, urbana). ultraviolet mutagenesis in bacteriophage t4. i. irradiation of extracellular phage particles. j. bacteriol. 91:1775-1780. 1966.-ultraviolet (uv) irradiation of extracellular t4 phage particles induces about 2 x 10(-4)r mutations per lethal hit. the mutants largely escape detection unless the irradiated phages are plated with very soft overlay agar. multiplicity reactivation is not a prerequisite for mutagenesis. a much higher frequency of base pai ...19665937237
partial exclusion of bacteriophage t2 by t4: an early function of the second linkage group. 19665939569
ultraviolet mutagenesis in bacteriophage t4. ii. photoreversal of mutational lesions.drake, john w. (university of illinois, urbana). ultraviolet mutagenesis in bacteriophage t4. ii. photoreversal of mutational lesions. j. bacteriol. 92:144-147. 1966.-t4r mutations were induced by ultraviolet irradiation of extracellular phage particles, using a phage mutant, v, which is particularly susceptible to photoreactivation. most of the induced r mutations could be subsequently photoreversed intracellularly with white light. ultraviolet irradiation induces both transitions and sign muta ...19665941273
t4 mutants unable to induce deoxycytidylate deaminase activity. 19665943540
suppression of amber and ochre rii mutants of bacteriophage t4 by streptomycin.orias, e. (university of california, santa barbara), and t. k. gartner. suppression of amber and ochre rii mutants of bacteriophage t4 by streptomycin. j. bacteriol. 91:2210-2215. 1966.-streptomycin-induced suppression of amber and ochre rii mutants of phage t4 was studied in a streptomycin-sensitive strain of escherichia coli and four nearly isogenic streptomycin-resistant derivatives of this strain, in the presence and in the absence of an ochre suppressor. most of the 12 rii mutants tested we ...19665943936
stimulation of recombination in multiplicity-reactivated bicomplexes and the genetic map length of phage t4. 19665952943
studies on the physiological defect in rii mutants of bacteriophage t4. 19665954174
intergenic cis-trans position effects in bacteriophage t4. 19665961481
effect of radiophosphorus decay on cistron function in bacteriophage t4. ii. stabilization to inactivation during phage growth. 19665963075
renaturation of t4 bacteriophage deoxyribonucleic acid in the presence of excess heterologous dna. 19665965051
the arrangement of information in dna molecules.the anatomy of dna molecules isolated from mature bacteriophage is reviewed. these molecules are linear, duplex dna consisting mainly of uninterrupted polynucleotide chains. certain phage (t5 and pb) contain four specifically located interruptions. while the nucleotide sequence of most of these molecules is unique (t5, t3, t7, lambda), some are circular permutations of each other (t2, t4, p22). partial degradation of these dna molecules by exonuclease iii predisposes some of them to form circles ...19665967428
x-ray-induced mutation in extracellular bacteriophage t4. 19665972691
[photodynamic inactivation of e. coli phage t4: studies of crossbreeding reactivation and protective effect of spermine]. 19665983099
[action of propylthiouracil on the transport of thyroxine t4-i-131]. 19665987607
[formation of t4-i-131 from dit-i-131 in presence of thyroxidase]. 19666011417
the effect of a bacterial mutator gene upon mutation rates in bacteriophage t4. 19665338816
depressant action of cyanide on recombination and synthesis of deoxyribonucleic acid in phage t4-escherichia coli complexes. 19665339144
limited genome expression in bacteriophage t4-infected escherichia coli. i. demonstration of the effect. 19665339599
limited genome expression in bacteriophage t4-infected escherichia coli. ii. development and examination of a model. 19665339600
studies on the nature of replicating dna in t4-infected escherichia coli. 19665337554
studies on the nature of the replicating dna in escherichia coli infected with certain amber mutants of phage t4. 19665337555
marker rescue of the adsorption properties of bacteriophage t4 by bacteriophage t2. 19665296603
effect of hydroxyurea on virus development. i. electron microscopic study of the effect on the development of bacteriophage t4.margaretten, william (college of physicians and surgeons of columbia university, new york, n.y.), councilman morgan, herbert s. rosenkranz, and harry m. rose. effect of hydroxyurea on virus development. i. electron microscopic study of the effect on the development of bacteriophage t4. j. bacteriol. 91:823-833. 1966.-double fixation in gluteraldehyde and osmium tetroxide and the application of lead staining revealed details of viral structure not previously observed in thin sections. bacteriopha ...19665327372
the synthesis of deoxycytidylate deaminase and dihydrofolate reductase and its control in escherichia coli infected with bacteriophage t4 and t-4 amber mutants. 19665327746
capacity of t4 dna to serve as template for purified escerichia coli rna polymerase. 19665331239
components in t4-infected cells associated with phage assembly. 19665331912
changes in leucine-specific srna after infection of e. coli by phages t2 and t4. 19665332365
inhibition of host nucleic acid synthesis by bacteriophage t4: effect of chloramphenicol at various multiplicities of infection. 19665335756
effect of infection of escherichia coli with bacteriophage t4 on the synthesis of ribosomes. 19665335757
acridine orange-sensitized photoinactivation of the capacity of escherichia coli for bacteriophage t4. 19665323163
gene-specific messenger rna: isolation by the deletion method.messenger rna molecules, homologous to a small portion of the genome of bacteriophage t4, have been isolated. rna fragments specific to the rii a and the rii b cistrons have been separated by hybridization with dna isolated from appropriate deletion mutants. an rna species homologous in nucleotide sequence to a defined part of the rii a cistron has been identified.19665323418
effects of mutations to streptomycin resistance on the rate of translation of mutant genetic information.gartner, t. k. (university of california, santa barbara), and e. orias. effects of mutations to streptomycin resistance on the rate of translation of mutant genetic information. j. bacteriol. 91:1021-1028. 1966.-the effects of mutations to streptomycin resistance of independent origin upon the translation of suppressible mutant information were studied in an isogenic series of strains of escherichia coli. the group of suppressible mutants included 1 mutation in the z gene of the lac operon of e. ...19665326090
spontaneous mutations accumulating in bacteriophage t4 in the complete absence of dna replication. 19665219679
inhibition of lysozyme synthesis by actinomycin d in bacteriophage t4-infected cells of escherichia coli. 19665219691
morphogenesis of bacteriophage t4 in extracts of mutant-infected cells. 19665221234
heteroduplex heterozygotes in bacteriophage t4 involving mutations of various dimensions. 19665221235
gene-specific mrna. ii. regulation of mrna synthesis in e. coli after infection with bacteriophage t4. 19665225509
change of a sequence of amino acids in phage t4 lysozyme by acridine-induced mutations. 19665229972
distances separating genetic markers in t4 dna. 19665230143
the amount of dna between genetic markers in phage t4. 19665230306
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