Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| vasculitis: an unusual manifestation in an hiv-infected patient. | human immunodeficiency virus (hiv) positive patients may develop vasculitis, either mediated by immunological factors or by direct vascular injury. we describe a patient who developed manifestations suggestive of extremities vasculitis with no identifiable risk factors other than hiv, epstein barr and herpes simplex virus (hsv) type 1 co-infection. physicians should be aware that vasculitis may have a heterogeneous presentation and occur associated with hiv infection. although unusual, this asso ... | 2015 | 26070539 |
| ebv bart micrornas target multiple pro-apoptotic cellular genes to promote epithelial cell survival. | epstein-barr virus (ebv) is a ubiquitous human γ-herpesvirus that can give rise to cancers of both b-cell and epithelial cell origin. in ebv-induced cancers of epithelial origin, including nasopharyngeal carcinomas (npcs) and gastric carcinomas, the latent ebv genome expresses very high levels of a cluster of 22 viral pre-mirnas, called the mir-barts, and these have previously been shown to confer a degree of resistance to pro-apoptotic drugs. here, we present an analysis of the ability of indiv ... | 2015 | 26070070 |
| isolated unilateral soft palate palsy following tonsillopharyngitis caused by epstein-barr virus infection. | soft palate palsy with or without pharyngeal or laryngeal paralysis or facial palsy has been described in the literature fewer than 40 times. of these cases, isolated unilateral soft palate palsy (occurring without any other neurologic manifestation) has been rare. most cases of isolated soft palate palsy were termed idiopathic in the past. in a few cases, a concomitant viral infection such as varicella zoster, herpes simplex, measles, and coxsackie a9 was diagnosed. we describe a case of isolat ... | 2015 | 26068386 |
| frequency of epstein--barr virus infection as detected by messenger rna for ebna 1 in histologically proven gastric adenocarcinoma in patients presenting to a tertiary care center in south india. | epstein-barr virus (ebv)-associated gastric carcinoma is a relatively uncommon entity detected in approximately 10% of gastric adenocarcinoma. | 2015 | 26068337 |
| human parechovius and enterovirus in neonates: distinct infections with overlapping features. | human parechoviruses (hpevs) have recently been added to the family picornaviridae, where enteroviruses (hev) belong. the specific characteristics of hpev infection in the neonate are not clear, and their involvement in neonatal infection is believed to be largely underestimated. hpev type 3 has been recently linked to sepsis-like illness and neurological involvement in the newborn. | 2015 | 26067868 |
| recovery of a human natural antibody against the noncollagenous-1 domain of type iv collagen using humanized models. | anti-glomerular basement membrane nephritis and goodpasture syndrome result from autoantibody (ab)-mediated destruction of kidney and lung. ab target the noncollagenous 1 (nc1) domain of alpha3(iv) collagen, but little is known about ab origins or structure. this ignorance is due in part to the inability to recover monoclonal ab by transformation of patients' blood cells. the aim of this study was to assess the suitability of two humanized models for this purpose. | 2015 | 26048777 |
| epstein-barr virus-associated pulmonary smooth muscle tumor after lung transplantation. | we report an epstein-barr virus (ebv)-associated pulmonary posttransplant smooth muscle tumor arising in the left lung of a 71-year-old bilateral lung transplant recipient nearly 3 years after transplantation, treated with thoracoscopic wedge resection. four previous smooth muscle tumors have been reported following lung transplantation. to our knowledge, this is the first reported case of an ebv-positive posttransplant smooth muscle tumor within the transplanted lung. we describe the clinical, ... | 2015 | 26046906 |
| printed flexible plastic microchip for viral load measurement through quantitative detection of viruses in plasma and saliva. | we report a biosensing platform for viral load measurement through electrical sensing of viruses on a flexible plastic microchip with printed electrodes. point-of-care (poc) viral load measurement is of paramount importance with significant impact on a broad range of applications, including infectious disease diagnostics and treatment monitoring specifically in resource-constrained settings. here, we present a broadly applicable and inexpensive biosensing technology for accurate quantification o ... | 2015 | 26046668 |
| multiple sclerosis and environmental factors: the role of vitamin d, parasites, and epstein-barr virus infection. | pathogenic mechanisms underlying multiple sclerosis development have yet to be clearly identified, but considerable evidence indicates that autoimmunity plays an important role in the etiology of the disease. it is generally accepted that autoimmune diseases like ms arise from complex interactions between genetic susceptibility and environmental factors. although environmental factors unequivocally influencing ms development have yet to be established, accumulating evidence singles out several c ... | 2015 | 26046559 |
| epstein-barr virus-associated lymphoepithelial carcinoma of the larynx. | lymphoepithelial carcinoma is a rare tumour, named after its histological resemblance to undifferentiated nasopharyngeal carcinoma. the pathogenesis of lymphoepithelial carcinoma remains unknown. this tumour has been described in several organs, but the larynx remains an exceptional site. | 2015 | 26043818 |
| high-dose therapy and autologous stem cell transplantation for extra-nodal nk/t lymphoma in patients from the western hemisphere: a study from the european society for blood and marrow transplantation. | extra-nodal nk/t lymphoma (enktl) is rare and more frequently encountered in east asia. the role of high-dose therapy and autologous stem cell transplantation (hdt-asct) for enktl is unclear. twenty-eight evaluable patients who had undergone hdt-asct in europe from 2000-2009 were studied. the median age was 47 years and patients had received a median of two lines of prior therapy. some 57% of patients were not in complete remission or beyond first complete remission at hdt-asct. the 1-year non-r ... | 2015 | 25899403 |
| epstein-barr virus dnaemia in iranian liver transplant recipients and assessment of its variation in posttransplant lymphproliferative disorder patients by quantitative polymerase chain reaction assay. | epstein-barr virus primary infection and/or reactivation may play a major role in the incidence of posttransplant lymphoproliferative disorder in organ recipients. we assessed epstein-barr virus viral load in liver transplant patients suspected of having epstein-barr virus/ posttransplant lymphoproliferative disorder at specified times after transplant and evaluated the clinical findings and posttransplant complications. | 2015 | 25894179 |
| bone marrow involvement by lymphoproliferative disorders after solid-organ transplant. | posttransplant lymphoproliferative disorders are classified as monomorphic, polymorphic, early lesions, or hodgkin lymphoma. bone marrow staging examination is recommended in posttransplant lymphoproliferative disorder patients. however, information about bone marrow involvement in these disorders is scarce. we evaluated 19 transplant patients with posttransplant lymphoproliferative disorder to investigate incidence of bone marrow involvement, associated morphologic changes, and prognosis. | 2015 | 25894151 |
| contrast patterns of cytomegalovirus and epstein-barr virus infection in pediatric living-donor liver transplant recipients. | cytomegalovirus and epstein-barr virus remain leading causes of morbidity and mortality in the living-donor liver transplant population, particularly in pediatric patients. herein we compare the incidence, timing, and risk factors for infection in this group. | 2015 | 25894132 |
| immunoglobulin rearrangement analysis from multiple lesions in the same patient using next-generation sequencing. | for patients who have multiple lymphomas with discordant pathology, it is relevant to determine whether there is one disseminated lymphoma or two unrelated lymphomas. patients with disseminated, clonally related lymphomas are usually treated with the most powerful drugs available, while patients with unrelated (primary) lymphomas receive mainly standard first-line therapies. | 2015 | 25891511 |
| splunc1 reduces the inflammatory response of nasopharyngeal carcinoma cells infected with the eb virus by inhibiting the tlr9/nf-κb pathway. | studies indicate that the natural immune-related protein short palate, lung, and nasal epithelium clone 1 (splunc1) plays an antitumor role in nasopharyngeal epithelial tissue. however, the detailed mechanism of the tumor-suppressor effect of splunc1 in the inflammatory microenvironment of epstein-barr virus (ebv)-associated nasopharyngeal carcinoma (npc) remains elusive. the aim of the present study was to explore how splunc1 reduces the inflammatory response of npc cells infected with ebv by r ... | 2015 | 25891128 |
| rectal hodgkin lymphoma in a patient with ulcerative colitis: a case study. | a case of hodgkin lymphoma located in the rectum of a patient with ulcerative colitis is described. the patient was a 44 year old male treated with thiopurines for ulcerative colitis for ten years. he was admitted with malaise, weight loss and abdominal pain. endoscopy revealed a large ulcerative lesion involving the rectum and distal part of the sigmoid colon. although it macroscopically resembled a rectal cancer, repeated biopsies did not reveal any malignancy. in order to resolve the symptoms ... | 2015 | 25890312 |
| primary central nervous system lymphoma in a rheumatoid arthritis patient treated with methotrexate: a case report. | rheumatoid arthritis is a systemic inflammatory disease characterized by synovitis and the destruction of articular structures in multiple joints. methotrexate is recommended as an anchor drug for rheumatoid arthritis treatment to achieve the therapeutic goal of reducing damage to joints and improving clinical score. however, several studies have shown that methotrexate has been associated with the development of lymphoproliferative disorders, namely methotrexate-associated lymphoproliferative d ... | 2015 | 25888766 |
| acute acalculous cholecystitis in a patient with primary epstein-barr virus infection: a case report and literature review. | epstein-barr virus (ebv) infection can lead to infectious mononucleosis syndrome with the typical symptoms of fever, pharyngitis, and lymphadenopathy. self-limited mild to moderate elevation of liver enzymes and hepatosplenomegaly are common. however, cholecystitis is not usually considered part of a primary ebv infection and ultrasound scan (uss) of the liver and gallbladder is not routinely performed. acute acalculous cholecystitis (aac) caused by etiologies other than primary ebv infection is ... | 2015 | 25887813 |
| advances in the immunopathogenesis of multiple sclerosis. | recent studies indicate a role for immune dysregulation in the pathogenesis of multiple sclerosis, an inflammatory demyelinating and degenerative disease of the central nervous system. this review addresses the current mechanisms of immune dysregulation in the development of multiple sclerosis, including the impact of environmental risk factors on immunity in both multiple sclerosis and its animal models. | 2015 | 25887768 |
| icaritin induces lytic cytotoxicity in extranodal nk/t-cell lymphoma. | extranodal nk/t-cell lymphoma (enkl) is an aggressive hematological malignancy associated with epstein-barr virus (ebv) infection. it is often resistant to conventional chemotherapy and has a poor prognosis. icaritin, a compound derived from chinese herbal medicine, herba epimedii, has been reported to exert antitumor effects on a variety of cancer cell lines. in the present study, we investigated the cytotoxic effects of icaritin on the two ebv-positive enkl cell lines snk-10 and snt-8, along w ... | 2015 | 25887673 |
| acquired hemophagocytic syndrome related to parainfluenza virus infection: case report. | we present the case of a patient with acquired hemophagocytic syndrome secondary to parainfluenza virus infection, a complication that has not, to the best of our knowledge, been previously reported. | 2015 | 25886447 |
| a chimeric ebv gp350/220-based vlp replicates the virion b-cell attachment mechanism and elicits long-lasting neutralizing antibodies in mice. | epstein-barr virus (ebv), an oncogenic gammaherpesvirus, causes acute infectious mononucleosis (aim) and is linked to the development of several human malignancies. there is an urgent need for a vaccine that is safe, prevents infection and/or limits disease. unique among human herpesviruses, glycoprotein (gp)350/220, which initiates ebv attachment to susceptible host cells, is the major ligand on the ebv envelope and is highly conserved. interaction between gp350/220 and complement receptor type ... | 2015 | 25885535 |
| epstein-barr virus infection in chronically inflamed periapical granulomas. | periapical granulomas are lesions around the apex of a tooth caused by a polymicrobial infection. treatment with antibacterial agents is normally performed to eliminate bacteria from root canals; however, loss of the supporting alveolar bone is typically observed, and tooth extraction is often selected if root canal treatment does not work well. therefore, bacteria and other microorganisms could be involved in this disease. to understand the pathogenesis of periapical granulomas more precisely, ... | 2015 | 25884725 |
| fully automated expansion and activation of clinical-grade natural killer cells for adoptive immunotherapy. | ex vivo expansion of natural killer (nk) cells is a strategy to produce large numbers of these effector cells for immunotherapy. however, the transfer of bench-top expansion protocols to clinically applicable methods is challenging for nk cell-based therapy because of regulatory aspects and scale-up issues. therefore, we developed an automated, large-scale nk cell expansion process. | 2015 | 25881519 |
| diffuse parenchymal lung disease as first clinical manifestation of gata-2 deficiency in childhood. | gata-2 transcription factor deficiency has recently been described in patients with a propensity towards myeloid malignancy associated with other highly variable phenotypic features: chronic leukocytopenias (dendritic cell-, monocyto-, granulocyto-, lymphocytopenia), increased susceptibility to infections, lymphatic vasculature abnormalities, and sensorineural deafness. patients often suffer from opportunistic respiratory infections; chronic pulmonary changes have been found in advanced disease. | 2015 | 25879889 |
| characterization of epstein-barr virus strains and lmp1-deletion variants in portugal. | variations in the genome sequence of epstein-barr virus (ebv) are thought to lead to differential interaction with host cells, immune evasion, and transformation. the discussion regarding ebv strains as having a geographic or disease-association has been increasing and the majority of studies are performed in asiatic populations. we developed a case-control study with 139 individuals, including 96 subjects with different malignancies and 43 healthy individuals, from the north region of portugal. ... | 2015 | 25879824 |
| melanogenesis-inhibitory activity and cancer chemopreventive effect of glucosylcucurbic acid from shea (vitellaria paradoxa) kernels. | two jasmonate derivatives, glucosylcucurbic acid (1) and methyl glucosylcucurbate (2), were isolated from the meoh extract of defatted shea (vitellaria paradoxa; sapotaceae) kernels. these and their deglucosylated derivatives, cucurbic acid (3) and methyl cucurbate (4), were evaluated for their melanogenesis-inhibitory and cancer chemopreventive potencies. compounds 1, 3, and 4 exhibited potent melanogenesis-inhibitory activities in α-melanocyte-stimulating hormone (α-msh)-stimulated b16 melanom ... | 2015 | 25879500 |
| lymph node flow cytometry as a prompt recognition of ultra early onset ptld: a successful case of rituximab treatment. | ultra early posttransplantation lymphoproliferative disorder (ptld) is a rare and fatal complication after hematopoietic stem cell transplantation (hsct). here we report, by lymph node (ln) flowcytometry, that we early recognized ultra early ptld after an hla-matched sibling allo-hsct followed by a successful treatment with anti-cd20 antibody (rituximab) in a patient in progress disease for angioimmunoblastic t-cell lymphoma (aitl). the patient was conditioned with a reduced intensity conditioni ... | 2015 | 25878909 |
| epstein-barr virus latent membrane protein 2 induces autophagy to promote abnormal acinus formation. | epstein-barr virus latent membrane protein 2a (lmp2a) induces many characteristics of carcinoma, including transformation, migration, invasion, and impaired differentiation. the mcf10a cell line differentiates to form hollow acini when grown in matrigel, and expression of lmp2a inhibited differentiation and anoikis induced by loss of matrix attachment. lmp2a-infected cells formed large, lobular structures rather than hollow acini. autophagy inhibitors impaired this abnormal growth and induced ca ... | 2015 | 25878108 |
| [molecular mechanisms of epstein-barr virus-induced lymphoid neoplasms]. | epstein-barr virus (ebv) infects human beings and latently persists in b-cells throughout life. ebv infection renders b cells immortal. in immunocompetent individuals, the expansion of ebv-infected b-cells is suppressed by cytotoxic t lymphocytes (ctl). however, once immunosuppression-induced ctl dysfunction or accelerated proliferation of infected cells due to gene mutation accumulation occurs, the infected cells proliferate leading to b-cell neoplasms. the products of the viral genome, i.e. lm ... | 2015 | 25876779 |
| epstein-barr virus-targeted therapy in nasopharyngeal carcinoma. | despite successful primary treatment of nasopharyngeal carcinoma (npc), the incidence of distant metastasis remains 25-34 %. treatment options are limited, and survival is poor. intratumoural epstein-barr virus (ebv) was used as treatment target. in npc, ebv is present in a latent state, expressing only few non-immunogenic viral products. gemcitabine and valproic acid can trigger ebv to the lytic state, wherein viral kinases are expressed, making ebv-positive tumour cells susceptible for antivir ... | 2015 | 25920375 |
| [nasopharyngeal carcinoma. brush biopsy with ebv-pcr is suitable as a screening test]. | the nasopharyngeal carcinoma (npc) is closely associated with the epstein-barr virus (ebv) infection. because each tumor cell in a patient regardless of histological subtype contains an identical copy of the viral clone, the virus is easily detectable at early pre-invasive lesions. nevertheless, the nasopharyngeal carcinoma is still usually diagnosed late, often not until they exhibit infested lymph nodes and / or distant metastases have occurred. canadian scientists have now discovered and anal ... | 2015 | 25918767 |
| a case of lymphoepithelioma-like carcinoma in the uterine cervix. | lymphoepithelioma-like carcinoma occurring in the reproductive organs is a rare variant of squamous cell carcinoma, and this tumor of the uterine cervix accounts for 0.7% of all primary cervical uterine neoplasms. associations with epstein-barr virus (ebv) and human papilloma virus (hpv) have been demonstrated in some studies. some investigators suggested that ebv has an important role in the initiation of lymphoepitheliomalike carcinoma in asian women. here we report the case of a 45-year-old j ... | 2015 | 25918614 |
| cellular immunotherapy with ex vivo expanded cord blood t cells in a humanized mouse model of ebv-associated lymphoproliferative disease. | donor lymphocyte infusion is not feasible in recipients of cord blood transplantation. | 2015 | 25917625 |
| [updates on epstein-barr virus-positive diffuse large b-cell lymphoma of the elderly]. | 2015 | 25916649 | |
| [presence of b-cell clones in angioimmunoblastic t cell lymphoma]. | to study the significance of b-cell clones in angioimmunoblastic t cell lymphoma (aitl) and the correlation with epstein-barr virus (ebv) and prognosis. | 2015 | 25916641 |
| [clinicopathologic features and association with epstein-barr virus infection in 235 cases of hodgkin lymphoma from northern china]. | to study the clinicopathologic features of hodgkin lymphoma (hl) occurring in northern china, association with epstein-barr virus (ebv) infection and concordance between ebv protein immunohistochemistry (ihc) and in-situ hybridization (ish). | 2015 | 25916637 |
| in-cell infection: a novel pathway for epstein-barr virus infection mediated by cell-in-cell structures. | epstein-barr virus (ebv) can infect both susceptible b lymphocytes and non-susceptible epithelial cells (ecs). viral tropism analyses have revealed two intriguing means of ebv infection, either by a receptor-mediated infection of b cells or by a cell-to-cell contact-mediated infection of non-susceptible ecs. herein, we report a novel "in-cell infection" mechanism for ebv infection of non-susceptible ecs through the formation of cell-in-cell structures. epithelial cne-2 cells were invaded by ebv- ... | 2015 | 25916549 |
| [allogeneic hematopoietic stem cell transplantation for epstein-barr virus associated hemophagocytic syndrome: a case report and literatures review]. | 2015 | 25916301 | |
| successful treatment of immediate allogeneic myeloablative hematopoietic stem cell transplantation from a hla-mismatched sibling donor for active systemic epstein-barr virus-positive t-cell lymphoproliferative disease of childhood following primary acute epstein-barr virus infection. | a 22-year-old female was admitted for sustained high fever and diagnosed with systemic epstein-barr virus-positive t-cell lymphoproliferative disease. as her clinical course was so aggressive, she immediately underwent allogeneic myeloablative bone marrow transplantation from an hla-mismatched sibling donor on hospital day 46. the patient has remained in complete remission for 3 years. | 2015 | 25914814 |
| the heat shock protein 90 inhibitor biib021 suppresses the growth of t and natural killer cell lymphomas. | epstein-barr virus (ebv), which infects not only b cells but also t and natural killer (nk) cells, is associated with a variety of lymphoid malignancies. because ebv-associated t and nk cell lymphomas are refractory and resistant to conventional chemotherapy, there is a continuing need for new effective therapies. ebv-encoded "latent membrane protein 1" (lmp1) is a major oncogene that activates nuclear factor kappa b (nf-κb), c-jun n-terminal kinase (jnk), and phosphatidylinositol 3-kinase signa ... | 2015 | 25914683 |
| epstein-barr virus is related with 5-aminosalicylic acid, tonsillectomy, and cd19(+) cells in crohn's disease. | to study anti-epstein-barr virus (ebv) igg antibodies in crohn's disease in relation to treatment, immune cells, and prior tonsillectomy/appendectomy. | 2015 | 25914477 |
| follicular helper t-cell lymphoma: a b-cell-rich variant of t-cell lymphoma. | follicular helper t-cell lymphoma is a recently described variant of t-cell lymphoma sharing the cell of origin with angioimmunoblastic t-cell lymphoma and with primary cutaneous cd4-positive small/medium t-cell lymphoma. to better characterize the morphologic and immunophenotypic features of follicular helper t-cell lymphoma, a series of 4 confidently diagnosed cases are analyzed. the overall morphologic pattern significantly overlaps with that of progressive transformation of germinal centers ... | 2015 | 25913305 |
| features of gastric carcinoma with lymphoid stroma associated with epstein-barr virus. | gastric carcinoma with lymphoid stroma (gcls) is a distinct histologic subtype of gastric cancer that is characterized by undifferentiated carcinoma mixed with prominent lymphoid infiltration. more than 80% of gcls cases are associated with epstein-barr virus (ebv) infection, but it is unclear if the virus affects disease progression. we investigated how ebv infection affects the clinical and pathologic features of gcls, as well as patients' outcomes. | 2015 | 25912839 |
| the role of epstein-barr virus infection in the pathogenesis of nasopharyngeal carcinoma. | nasopharyngeal carcinoma (npc) is closely associated with epstein-barr virus (ebv) infection. ebv episomes are detected in almost all npc cells. the role of ebv in npc pathogenesis has long been postulated but remains enigmatic. in contrast to infection of b lymphocytes, ebv infection does not directly transform nasopharyngeal epithelial cells into proliferative clones with malignant potential. ebv infection of normal pharyngeal epithelial cells is predominantly lytic in nature. genetic alterati ... | 2015 | 25910483 |
| epstein-barr virus-positive nodal t/nk-cell lymphoma: an analysis of 15 cases with distinct clinicopathological features. | nodal peripheral t-cell lymphoma, not otherwise specified, is a heterogeneous entity with variable biologic behavior. we analyze the clinicopathological features of 15 patients with epstein-barr virus-positive (ebv+) nodal t/nk-cell lymphoma, including 9 males and 6 females, with a median age of 64 years. all patients presented with multiple lymphadenopathy with common b symptoms (80%, 12/15) at an advanced ann arbor stage (iii, iv) (87%, 13/15). the international prognostic index was high or hi ... | 2015 | 25907865 |
| [the clinical significance of serum epstein-barr virus-determined nuclear antigen 1 (ebna1)/latent membrane protein 1 (lmp1) assay in patients with nasal type extranodal nk/t-cell lymphoma]. | to explore the clinical significance of the serum epstein-barr virus-determined nuclear antigen 1 (ebna1)/latent membrane protein 1 (lmp1) in patients with extranodal nk/t-cell lymphoma, nasal type (enkl). | 2015 | 25907839 |
| the pten-akt-mtor/rictor pathway in nasal natural killer cell lymphoma is activated by mir-494-3p via pten but inhibited by mir-142-3p via rictor. | nasal natural killer (nk) cell lymphoma (nnl) is an epstein-barr virus-associated lymphoma of cytotoxic nk cell origin. the epstein-barr virus-encoded mir-bart20-5p inhibits t-bet (tbx21), the master transcription factor of cytotoxic nk cells. to further explore the roles of mirnas in nnls, we measured the mirna expression profiles of 36 nnls. mir-21, mir-142-3p, mir-126, mir-451, and mir-494-3p were the top five mirnas with the highest expression levels. by using pathway analysis, we identified ... | 2015 | 25907832 |
| the role of aging in idiopathic pulmonary fibrosis. | idiopathic pulmonary fibrosis (ipf) has been gathering interest in recent years and as such this review will focus on the potential contributions that age plays on its onset and prevalence. environmental stress over time caused by the inhalation of foreign substances results in subsequent damage and repair of lung tissue. this damage prematurely causes a decrease in stem cell differentiation potential. in conjunction with declining proliferation, the correlation between age and general attenuati ... | 2015 | 25903793 |
| ranbpm regulates zta-mediated transcriptional activity in epstein-barr virus. | epstein-barr virus (ebv) expresses two immediate-early proteins, rta and zta, which are key transcription factors that can form a complex with mcaf1 at zta-responsive elements (zres) to synergistically activate several viral lytic genes. our previous research indicated that ranbpm interacts with rta and enhances rta sumoylation. here we showed that ranbpm binds to zta in vitro and in vivo, and acts as an intermediary protein in rta-zta complex formation. the rta-ranbpm-zta complex was observed t ... | 2015 | 25900136 |
| the ebna-2 n-terminal transactivation domain folds into a dimeric structure required for target gene activation. | epstein-barr virus (ebv) is a γ-herpesvirus that may cause infectious mononucleosis in young adults. in addition, epidemiological and molecular evidence links ebv to the pathogenesis of lymphoid and epithelial malignancies. ebv has the unique ability to transform resting b cells into permanently proliferating, latently infected lymphoblastoid cell lines. epstein-barr virus nuclear antigen 2 (ebna-2) is a key regulator of viral and cellular gene expression for this transformation process. the n-t ... | 2015 | 26024477 |
| epstein barr virus-positive mucocutaneous ulcer of the colon associated hodgkin lymphoma in crohn's disease. | epstein barr virus (ebv) positive mucocutaneous ulcers (ebvmcu) form part of a spectrum of ebv-associated lymphoproliferative disease. they have been reported in the setting of immunosenescence and iatrogenic immunosuppression, affecting the oropharyngeal mucosa, skin and gastrointestinal tract (git). case reports and series to date suggest a benign natural history responding to conservative management, particularly in the git. we report an unusual case of ebvmcu in the colon, arising in the set ... | 2015 | 26019475 |
| cross talk between ebv and telomerase: the role of tert and notch2 in the switch of latent/lytic cycle of the virus. | epstein-barr virus (ebv)-associated malignancies, as well as lymphoblastoid cell lines (lcls), obtained in vitro by ebv infection of b cells, express latent viral proteins and maintain their ability to grow indefinitely through inappropriate activation of telomere-specific reverse transcriptase (tert), the catalytic component of telomerase. our previous studies demonstrated that high levels of tert expression in lcls prevent the activation of ebv lytic cycle, which is instead triggered by tert s ... | 2015 | 26018735 |
| epstein-barr virus-related post-transplant lymphoproliferative disorder in the skin. | 2015 | 26017499 | |
| long-term outcome of extranodal nk/t cell lymphoma patients treated with postremission therapy using ebv lmp1 and lmp2a-specific ctls. | extranodal nk/t-cell lymphoma (enktcl) is associated with latent epstein-barr virus (ebv) infection and frequent relapse even after complete response (cr) to intensive chemotherapy and radiotherapy. the expression of ebv proteins in the tumor provides targets for adoptive immunotherapy with antigen-specific cytotoxic t cells (ctl). to evaluate the efficacy and safety of ebv latent membrane protein (lmp)-1 and lmp-2a-specific ctls (lmp1/2a ctls) stimulated with lmp1/2a rna-transferred dendritic c ... | 2015 | 26017177 |
| integrated genomic analysis suggests mll3 is a novel candidate susceptibility gene for familial nasopharyngeal carcinoma. | little is known about genetic factors associated with nasopharyngeal carcinoma (npc). to gain insight into npc etiology, we performed whole exome sequencing on germline and tumor dna from three closely related family members with npc. | 2015 | 26014803 |
| [expression of cd163 in children with epstein-barr virus infection]. | to study the clinical significance of cd163 in the diagnosis and the evaluation of severity and prognosis of childhood hemophagocytic lymphohistiocytosis (hlh). | 2015 | 26014702 |
| treating burkitt lymphoma in adults. | burkitt lymphoma is an uncommon form of aggressive lymphoma affecting approximately 1200 patients per year in the usa. it is characterized by a translocation involving the myc oncogene. three subtypes of burkitt lymphoma are recognized: the endemic form, occurring primarily in africa and associated with the epstein-barr virus (ebv); the sporadic form, representing less than 3 % of all non-hodgkin lymphomas (nhl); and the immunodeficiency-associated form, occurring primarily in hiv-infected patie ... | 2015 | 26013028 |
| genotypic analysis and latent membrane protein 1 expression of epstein-barr virus in extranodal nk/t-cell lymphoma from northern chinese patients. | as the most common nk/t-cell lymphoma in asian countries, extranodal nk/t-cell lymphoma, nasal type (enktl), has unique clinical features and a strong association with epstein-barr virus (ebv). in order to gain a preliminary understanding of the relationship between enktl and ebv, we performed genotypic analysis of ebv and investigated lmp1 expression in extranodal nk/t-cell lymphoma. our study shows that enktl is an ebv-associated malignancy and that a, c and f are the predominant ebv genotypes ... | 2015 | 26008210 |
| intrahepatic cholangiocarcinoma with lymphoepithelioma-like carcinoma components not associated with epstein-barr virus: report of a case. | a carcinoma displaying undifferentiated features with dense lymphoplasmacytic infiltration is defined as lymphoepithelioma-like carcinoma (lelc). intrahepatic cholangiocarcinoma (icc) with lelc components is rare, and most lelcs are associated with epstein-barr virus (ebv). we report here on a case of icc with lelc components not associated with ebv. a 65-year-old woman was incidentally found to have a hepatic tumor in the caudate lobe. an extended right hepatectomy with lymphadenectomy was perf ... | 2015 | 25875552 |
| changes in expression induced by epstein-barr virus lmp1-ctar1: potential role of bcl3. | the epstein-barr virus protein latent membrane protein 1 (lmp1) has two nf-κb activating domains within its intracellular carboxy terminus (carboxy-terminal activating region 1 [ctar1] and ctar2). lmp1-ctar1 is required for b-lymphocyte transformation, is capable of transforming rodent fibroblasts, and uniquely activates phosphoinositol (pi3) kinase, the noncanonical nf-κb pathway, and expression of the epidermal growth factor receptor (egfr). in this study, the effects of lmp1-ctar1 on cellular ... | 2015 | 25873381 |
| epstein-barr virus and human herpes virus 6 type a dna enhance il-17 production in mice. | several studies have shown a potential association between the herpesviridae members, the epstein-barr virus (ebv) and human herpes virus 6 (hhv-6), and an increased risk of autoimmune disease development. because of the ability of these viruses to cause recurrent infections, various viral antigens, including viral dna, are consistently shed. these antigens may then play a role in triggering autoimmune processes or contributing to autoimmune mechanisms. therefore, this study examined whether the ... | 2015 | 25870901 |
| exosomal sorting of the viral oncoprotein lmp1 is restrained by traf2 association at signalling endosomes. | the epstein-barr virus (ebv)-encoded oncoprotein latent membrane protein 1 (lmp1) constitutively activates nuclear factor κb (nfκb) from intracellular membranes to promote cell growth and survival. lmp1 associates with cd63 in intracellular membranes and is released via exosomes. whether tumour necrosis factor (tnf) receptor-associated factors (trafs) mediate lmp1 nfκb signalling from endosomes and modulate exosomal sorting is unknown. in this article, we show that lmp1-traf2 signalling complexe ... | 2015 | 25865256 |
| polymorphism in mature microrna-608 sequence is associated with an increased risk of nasopharyngeal carcinoma. | accumulative evidences indicated that micrornas (mirnas) can function as tumor suppressors and oncogenes, in which genetic variations are implicated in various cancer susceptibilities. however, it remains unclear whether single nucleotide polymorphisms (snps) in mature mirna sequence alter nasopharyngeal carcinoma (npc) susceptibility. in this study, we analyzed associations between eight snps in mirna mature sequences (i.e., rs3746444t>c in hsa-mir-499, rs4919510c>g in hsa-mir-608, rs13299349g> ... | 2015 | 25861865 |
| low grade pulmonary lymphomatoid granulomatosis with an endobronchial mass. | lymphomatoid granulomatosis (lyg) is an angiocentric and angiodestructive neoplastic proliferation of b and t lymphocytes commonly involving the lungs. epstein-barr virus is commonly detected in lesional cells. we report a case of a 54-year-old female with underlying monoclonal gammopathy of unknown significance who presented with a 4 week history of dyspnea and cough. computed tomography scan of the chest showed multiple lung nodules as well as endobronchial narrowing causing atelectasis at the ... | 2015 | 25861350 |
| diagnosing lymphoma in a setting with a high burden of infection: a pediatric case of epstein-barr virus-associated aggressive b-cell lymphoma with t(8;14) (q23;q32) and extensive necrosis mimicking tuberculosis. | the association of lymphoma with necrotic granuloma can pose diagnostic challenges and delay treatment, especially in settings with a high burden of infection. in these settings, the timely use of cytogenetic and molecular methods is most relevant. here, we report a case of b-cell lymphoma with t (8;14) in a 5-year-old male child. the lymphoma was associated with necrotic granuloma and was initially misdiagnosed as tuberculosis. polymerase chain reaction was used to detect clonal lymphoprolifera ... | 2015 | 25860476 |
| epstein-barr virus in gastro-esophageal adenocarcinomas - single center experiences in the context of current literature. | epstein-barr virus (ebv)-associated gastric carcinomas (gc) represent a distinct and well-recognized subtype of gastric cancer with a prevalence of around 10% of all gc. in contrast, ebv has not been reported to play a major role in esophageal adenocarcinomas (eac) and adenocarcinomas of the gastro-esophageal junction (gej). we report our experiences on ebv in collections of gastro-esophageal adenocarcinomas from two surgical centers and discuss the current state of research in this field. tumor ... | 2015 | 25859432 |
| severe thrombocytopenia and recurrent epistaxis associated with primary epstein-barr virus infection. | infectious mononucleosis, caused by the epstein-barr virus (ebv), generally follows a benign, yet protracted course, with the majority of symptoms being systemic somatic symptoms. rarely, the clinical picture can be complicated by more acute severe haemotological sequelae of the disease, requiring hospitalisation and causing diagnostic uncertainty, particularly when distinguishing between a viral illness and a lymphoproliferative disorder. we describe the case of a young male patient who present ... | 2015 | 25858924 |
| telomerase activity impacts on epstein-barr virus infection of ags cells. | the epstein-barr virus (ebv) is transmitted from host-to-host via saliva and is associated with epithelial malignancies including nasopharyngeal carcinoma (npc) and some forms of gastric carcinoma (gc). nevertheless, ebv does not transform epithelial cells in vitro where it is rapidly lost from infected primary epithelial cells or epithelial tumor cells. long-term infection by ebv, however, can be established in htert-immortalized nasopharyngeal epithelial cells. here, we hypothesized that incre ... | 2015 | 25856387 |
| the ebna3 family of epstein-barr virus nuclear proteins associates with the usp46/usp12 deubiquitination complexes to regulate lymphoblastoid cell line growth. | the epstein-barr virus (ebv) nuclear proteins ebna3a, ebna3b, and ebna3c interact with the cell dna binding protein rbpj and regulate cell and viral genes. repression of the cdkn2a tumor suppressor gene products p16(ink4a) and p14(arf) by ebna3a and ebna3c is critical for ebv mediated transformation of resting b lymphocytes into immortalized lymphoblastoid cell lines (lcls). to define the composition of endogenous ebna3 protein complexes, we generated lymphoblastoid cell lines (lcls) expressing ... | 2015 | 25855980 |
| different prognostic values of plasma epstein-barr virus dna and maximal standardized uptake value of 18f-fdg pet/ct for nasopharyngeal carcinoma patients with recurrence. | to evaluate and compare the prognostic value of epstein-barr virus (ebv) dna and maximal standard uptake values (suvmax ) of 18f-fluoro-2-deoxy-d-glucose positron emission tomography (18f-fdg-pet) in subgroups of nasopharyngeal carcinoma (npc) patients with locoregional or distant recurrence. | 2015 | 25853677 |
| ebna2 binds to genomic intervals associated with multiple sclerosis and overlaps with vitamin d receptor occupancy. | epstein-barr virus (ebv) is a non-heritable factor that associates with multiple sclerosis (ms). however its causal relationship with the disease is still unclear. the virus establishes a complex co-existence with the host that includes regulatory influences on gene expression. hence, if ebv contributes to the pathogenesis of ms it may do so by interacting with disease predisposing genes. to verify this hypothesis we evaluated ebv nuclear antigen 2 (ebna2, a protein that recent works by our and ... | 2015 | 25853421 |
| a rare cause of acquired immune deficiency syndrome related pancytopenia. | a 21-year-old male with acquired immune deficiency syndrome, not on highly active antiretroviral treatment (haart) was admitted after complaining of headache and intermittent diarrhea, found to have cryptococcal meningitis. during the course of his hospitalization, patient developed pancytopenia. anemia panel, serologies including epstein barr virus, cytomegalovirus, and parvovirus were negative. patient then developed high grade fever with elevated liver enzymes. blood cultures, urine cultures, ... | 2015 | 25852844 |
| killer b lymphocytes and their fas ligand positive exosomes as inducers of immune tolerance. | induction of immune tolerance is a key process by which the immune system is educated to modulate reactions against benign stimuli such as self-antigens and commensal microbes. understanding and harnessing the natural mechanisms of immune tolerance may become an increasingly useful strategy for treating many types of allergic and autoimmune diseases, as well as for improving the acceptance of solid organ transplants. our laboratory and others have been interested in the natural ability of some b ... | 2015 | 25852690 |
| 7α, 25-dihydroxycholesterol-mediated activation of ebi2 in immune regulation and diseases. | ebi2, aka gpr183, is a g-couple receptor originally identified in 1993 as one of main genes induced in burkitt's lymphoma cell line bl41 by epstein-barr virus (ebv) infection. after it was reported in 2009 that the receptor played a key role in regulating b cell migration and responses, we initiated an effort in looking for its endogenous ligand. in 2011 we and another group reported the identification of 7α, 25-dihydroxyxcholesterol (7α, 25-ohc), an oxysterol, as the likely physiological ligand ... | 2015 | 25852561 |
| lymphoepithelioma-like cholangiocarcinoma: a mimic of hepatocellular carcinoma on imaging features. | primary lymphoepithelioma-like carcinoma in the liver is extremely rare. a few cases of lymphoepithelioma-like cholangiocarcinoma have been reported, but few radiologic features were described. we reviewed 23 cases of lymphoepithelioma-like cholangiocarcinoma reported between 1996 and 2014 and describe a rare case of a 35-year-old woman in our hospital who was diagnosed with lymphoepithelioma-like cholangiocarcinoma of the liver and was a hepatitis b carrier. the tumor (1.6 cm) in our patient ap ... | 2015 | 25852298 |
| healthy rabbits are susceptible to epstein-barr virus infection and infected cells proliferate in immunosuppressed animals. | epstein-barr virus (ebv) is an oncogenic virus implicated in the pathogenesis of several human malignancies. however, due to the lack of a suitable animal model, a number of fundamental questions pertaining to the biology of ebv remain poorly understood. here, we explore the potential of rabbits as a model for ebv infection and investigate the impact of immunosuppression on viral proliferation and gene expression. | 2015 | 25851649 |
| animal models of epstein barr virus infection. | epstein barr virus (ebv) was the first human tumor virus to be described. despite its discovery now more than fifty years ago, immune control of this virus is still not very well understood and no vaccine is available. this knowledge gap is due in part to the lack of a preclinical small animal model which can faithfully recapitulate ebv infection and immune control, and would allow testing of ebv specific vaccine candidates. with the advent of mice with reconstituted human immune system compartm ... | 2015 | 25846986 |
| prevention of ebv lymphoma development by oncolytic myxoma virus in a murine xenograft model of post-transplant lymphoproliferative disease. | epstein-barr virus (ebv) has been associated with a variety of epithelial and hematologic malignancies, including b-, t- and nk cell-lymphomas, hodgkin's disease (hd), post-transplant lymphoproliferative diseases (lpds), nasopharyngeal and gastric carcinomas, smooth muscle tumors, and hiv-associated lymphomas. currently, treatment options for ebv-associated malignancies are limited. we have previously shown that myxoma virus specifically targets various human solid tumors and leukemia cells in a ... | 2015 | 25843801 |
| epstein-barr virus-associated lymphomas. | the epstein-barr virus (ebv) is the first identified human virus with a proven association with the pathogenesis of cancer. to maintain the integrity of the viral genome and to "get out" of the control of the host immune system, in the phase of the latent infection ebv shows the expression of several genes, including genes for six nuclear antigens, three latent membrane proteins, two short non-coding rnas, and bamhi-a rightward transcripts. the different patterns of expression of these latent ge ... | 2015 | 25843733 |
| epstein-barr virus- and kaposi sarcoma-associated herpesvirus-related malignancies in the setting of human immunodeficiency virus infection. | the human gammaherpesvirus family includes epstein-barr virus (ebv) and human herpesvirus (hhv)-8, also known as kaposi sarcoma-associated herpesvirus (kshv). in human immunodeficiency virus (hiv)-infected patients, both ebv and kshv have been implicated in the development of a wide range of tumors. kshv-associated diseases include kaposi sarcoma (ks), primary effusion lymphoma (pel), and multicentric castleman disease (mcd). ebv has been associated with the development of several malignancies, ... | 2015 | 25843730 |
| the epidemiology of cancers in human immunodeficiency virus infection and after organ transplantation. | the authors provide an update on the association between immune deficiency and cancer risk in people with human immunodeficiency virus (hiv) and in solid organ transplant recipients. over the past decade, it has become clear that a wider range of about 20 mostly infection-related cancers occur at increased rates in people with immune deficiency. the human herpes virus 8 (hhv8) and epstein barr virus (ebv)-related cancers of kaposi sarcoma (ks) and non-hodgkin lymphoma (nhl) are most closely rela ... | 2015 | 25843729 |
| cancer risk in the relatives of patients with nasopharyngeal carcinoma—a register-based cohort study in sweden. | little is known about cancer susceptibility among relatives of nasopharyngeal carcinoma (npc) patients in non-endemic areas. we conducted a register-based cohort study to assess the relative risks (rrs) of cancer in families of npc probands in sweden. | 2015 | 25928707 |
| the epstein-barr virus latent membrane protein-1 (lmp1) 30-bp deletion and xhoi-polymorphism in nasopharyngeal carcinoma: a meta-analysis of observational studies. | epstein-barr virus (ebv) is considered to be closely associated with nasopharyngeal carcinoma (npc), in which ebv-encoded latent membrane protein 1 (lmp1) was found to have an oncogenic role. however, the results published on the lmp1 polymorphism are inconsistent. in the present study, we performed a meta-analysis to determine the frequency of the associations and a more precise association between npc and ebv lmp1 gene variants (30-bp deletion (del)/xhoi-loss). | 2015 | 25927427 |
| new noncoding lytic transcripts derived from the epstein-barr virus latency origin of replication, orip, are hyperedited, bind the paraspeckle protein, nono/p54nrb, and support viral lytic transcription. | we have previously shown that the epstein-barr virus (ebv) likely encodes hundreds of viral long noncoding rnas (vlncrnas) that are expressed during reactivation. here we show that the ebv latency origin of replication (orip) is transcribed bi-directionally during reactivation and that both leftward (oriptls) and rightward (oriptrs) transcripts are largely localized in the nucleus. while the oriptls are most likely noncoding, at least some of the oriptrs contain the bcrf1/vil10 open reading fram ... | 2015 | 25926645 |
| cd20-positive nodal natural killer/t-cell lymphoma with cutaneous involvement. | cd20-positive natural killer (nk)/t-cell lymphoma is extremely rare. we describe a case of a cd20-positive nodal nk/t-cell lymphoma with cutaneous involvement in a 32-year-old man. the patient presented with fever, night sweats, right inguinal lymphadenopathy and multiple violaceous to erythematous nodules and plaques on the back and bilateral legs. immunohistochemical analysis showed diffusely and strongly positive staining for cd3, cd3 epsilon, cd43, cd56, tia-1 and cd20 but negative staining ... | 2015 | 25924981 |
| comparative methylome analysis in solid tumors reveals aberrant methylation at chromosome 6p in nasopharyngeal carcinoma. | altered patterns of dna methylation are key features of cancer. nasopharyngeal carcinoma (npc) has the highest incidence in southern china. aberrant methylation at the promoter region of tumor suppressors is frequently reported in npc; however, genome-wide methylation changes have not been comprehensively investigated. therefore, we systematically analyzed methylome data in 25 primary npc tumors and nontumor counterparts using a high-throughput approach with the illumina humanmethylation450 bead ... | 2015 | 25924914 |
| gammaherpesvirus tegument protein orf33 is associated with intranuclear capsids at an early stage of the tegumentation process. | herpesvirus nascent capsids, after assembly in the nucleus, must acquire a variety of tegument proteins during maturation. however, little is known about the identity of the tegument proteins that are associated with capsids in the nucleus or the molecular mechanisms involved in the nuclear egress of capsids into the cytoplasm, especially for the two human gammaherpesviruses epstein-barr virus (ebv) and kaposi's sarcoma-associated herpesvirus (kshv), due to a lack of efficient lytic replication ... | 2015 | 25717105 |
| cellular stat3 functions via pcbp2 to restrain epstein-barr virus lytic activation in b lymphocytes. | a major hurdle to killing epstein-barr virus (ebv)-infected tumor cells using oncolytic therapy is the presence of a substantial fraction of ebv-infected cells that does not support the lytic phase of ebv despite exposure to lytic cycle-promoting agents. to determine the mechanism(s) underlying this refractory state, we developed a strategy to separate lytic from refractory ebv-positive (ebv(+)) cells. by examining the cellular transcriptome in separated cells, we previously discovered that high ... | 2015 | 25717101 |
| ebv-lmp1 targeted dnazyme enhances radiosensitivity by inhibiting tumor angiogenesis via the jnks/hif-1 pathway in nasopharyngeal carcinoma. | lmp1, which is encoded by the epstein-barr virus, is proposed to be one of the major oncogenic factors involved in nasopharyngeal carcinoma (npc). previous studies demonstrated that down-regulation of lmp1 by lmp1-targeted dnazyme (dz1) increases the radiosensitivity of npc. however, the mechanism by which dz1 contributes to this radiosensitivity remains unclear. in this study, we determined whether a dz1 blockade of lmp1 expression has an overall positive effect on the radiotherapy of npcs by r ... | 2015 | 25714020 |
| cytomegalovirus-specific t-cell therapies: current status and future prospects. | adoptive transfer of t cells specific for viral pathogens offers an attractive method for hastening immune reconstitution and protective immunity in patients following stem cell transplantation. the largest experience to date has been in the context of treatment or prevention of cytomegalovirus or epstein-barr virus. a number of technical hurdles have now been overcome allowing consideration of more widespread application of products compliant with good manufacturing practice regulations, and of ... | 2015 | 25713989 |
| in vitro human cell line models to predict clinical response to anticancer drugs. | in vitro human cell line models have been widely used for cancer pharmacogenomic studies to predict clinical response, to help generate pharmacogenomic hypothesis for further testing, and to help identify novel mechanisms associated with variation in drug response. among cell line model systems, immortalized cell lines such as epstein-barr virus (ebv)-transformed lymphoblastoid cell lines (lcls) have been used most often to test the effect of germline genetic variation on drug efficacy and toxic ... | 2015 | 25712190 |
| risk factors of epstein-barr virus infection among united states children: data from the national health and nutrition examination survey (nhanes), 2009-2010. | epstein-barr virus (ebv) has become a common medical condition in adolescents and young children. the objective of this study was to examine the association of low dietary intake and food insecurity with ebv infection. | 2015 | 25711918 |
| human leukocyte antigen (hla) a*1101-restricted epstein-barr virus-specific t-cell receptor gene transfer to target nasopharyngeal carcinoma. | infusing virus-specific t cells is effective treatment for rare epstein-barr virus (ebv)-associated posttransplant lymphomas, and more limited success has been reported using this approach to treat a far more common ebv-associated malignancy, nasopharyngeal carcinoma (npc). however, current approaches using ebv-transformed lymphoblastoid cell lines to reactivate ebv-specific t cells for infusion take 2 to 3 months of in vitro culture and favor outgrowth of t cells targeting viral antigens expres ... | 2015 | 25711537 |
| general and virus-specific immune cell reconstitution after double cord blood transplantation. | cord blood transplantation (cbt) is curative for many patients with hematologic malignancies but is associated with delayed immune recovery and an increased risk of viral infections compared with hla-matched bone marrow or peripheral blood progenitor cell transplantation. in this study we evaluated the significance of lymphocyte recovery in 125 consecutive patients with hematologic malignancies who underwent double-unit cbt (ducbt) with an antithymocyte globulin-containing regimen at our institu ... | 2015 | 25708219 |
| secondary hemophagocytic lymphohistiocytosis associated with epstein-barr virus. | 2015 | 25708060 | |
| the role of environment and lifestyle in determining the risk of multiple sclerosis. | ms is a complex disease where both genetic and environmental factors contribute to disease susceptibility. the substantially increased risk of developing ms in relatives of affected individuals gives solid evidence for a genetic base for susceptibility, whereas the modest familial risk, most strikingly demonstrated in the twin studies, is a very strong argument for an important role of lifestyle/environmental factors in determining the risk of ms, sometimes interacting with ms risk genes. lifest ... | 2015 | 25707369 |
| the immunology of epstein-barr virus-induced disease. | epstein-barr virus (ebv) is usually acquired silently early in life and carried thereafter as an asymptomatic infection of the b lymphoid system. however, many circumstances disturb the delicate ebv-host balance and cause the virus to display its pathogenic potential. thus, primary infection in adolescence can manifest as infectious mononucleosis (im), as a fatal illness that magnifies the immunopathology of im in boys with the x-linked lymphoproliferative disease trait, and as a chronic active ... | 2015 | 25706097 |
| diffuse large b-cell lymphoma arising from chronic tuberculous empyema. | pyothorax-associated lymphoma is a relatively rare type of lymphoma that occurs in patients who have long histories of tuberculous pleuritis or induced pneumothorax. it is a type of non-hodgkin's lymphoma of mainly the b-cell phenotype and is strongly associated with epstein-barr virus infection. a majority of these cases have been reported in japan, although some cases have occurred in western countries. here, we describe a case of pyothorax-associated lymphoma in a patient with a 30-year histo ... | 2015 | 25705606 |