Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| [susceptibility of branhamella catarrhalis to antibiotics]. | a total of 98 isolates of branhamella catarrhalis were examined for their susceptibility to antibiotics using serial dilution method. nitrocefin test was employed for detection of beta-lactamase activity. it was found that most of the isolates (71%) were resistant to ampicillin. resistance to this antibiotic was accompanied by ability to beta-lactamase production. on the other hand, all isolates were susceptible to amoxicillin + clavulanic acid combination. almost all isolates were susceptible t ... | 2004 | 15773499 |
| [moraxella catarrhalis in chronic and relapsing respiratory tract infections in children]. | examination of 700 children with chronic and relapsing respiratory tract infections showed that during the period from 1996 to 2003 moraxella catarrhalis strains were isolated from the sputum of 5.5-9.7% of the patients. the frequency of the emergence was the third after haemophilus influenzae and streptococcus pneumoniae. in healthy children m. catarrhalis was isolated in 2.7% of the cases. the most frequent detection of m. catarrhalis was stated in children under 1 year (4.5%). the antibiotic ... | 2004 | 15727145 |
| short-course therapy for acute sinusitis: how long is enough? | this review examines the issues surrounding short-course antibiotic therapy of acute sinusitis. acute bacterial sinusitis is a common community-acquired infection defined as inflammation of one or more paranasal sinuses, most often the maxillary sinus. it is estimated that 0.5-5% of colds are complicated by acute sinusitis. up to 1 in 20 upper respiratory tract infections is complicated by bacterial sinusitis, most often caused by streptococcus pneumoniae, haemophilus influenzae, moraxella catar ... | 2004 | 15606217 |
| population pharmacokinetics and pharmacodynamics of garenoxacin in patients with community-acquired respiratory tract infections. | garenoxacin (t-3811me, bms-284756) is a novel, broad-spectrum des-f(6) quinolone currently under study for the treatment of community-acquired respiratory tract infections. this analysis assessed garenoxacin population pharmacokinetics and exposure-response relationships for safety (adverse effects [ae]) and antimicrobial activity (clinical cure and bacteriologic eradication of streptococcus pneumoniae and the grouping of haemophilus influenzae, haemophilus parainfluenzae, and moraxella catarrha ... | 2004 | 15561855 |
| [molecular characterization of bro beta-lactamases of moraxella catarrhalis strains isolated from carrier children]. | nasopharyngeal carriage of moraxella catarrhalis is a risk factor for upper respiratory tract infections and otitis media. in this study, we aimed to characterize bro beta-lactamases of m. catarrhalis strains isolated from 64 children without any symptoms of respiratory disease. gram negative diplococci grown on selective media and which are catalase, oxidase, dnase, nitrate reduction positive, glucose, maltose, sucrose and lactose fermentation negative, were diagnosed as m. catarrhalis. antibio ... | 2004 | 15700658 |
| the potential effect of widespread use of pneumococcal conjugate vaccines on the practice of pediatric otolaryngology: the case of acute otitis media. | this review provides the otolaryngologist with the evolving understanding of various aspects of pneumococcal conjugate vaccines (pcvs) that are related to their effect on the respiratory tract | 2004 | 15548905 |
| acute exacerbation of chronic bronchitis: a primary care consensus guideline. | to develop consensus on appropriate treatment for acute exacerbation of chronic bronchitis (aecb). characteristics and etiology: patients with chronic bronchitis have an irreversible reduction in maximal airflow velocity and a productive cough on most days of the month for 3 months over 2 consecutive years. an aecb is characterized by a period of unstable lung function with worsening airflow and other symptoms. most (80%) cases of aecb are due to infection, with half due to aerobic bacteria. the ... | 2004 | 15521160 |
| the emerging pathogen moraxella catarrhalis interacts with complement inhibitor c4b binding protein through ubiquitous surface proteins a1 and a2. | moraxella catarrhalis ubiquitous surface protein a2 (uspa2) mediates resistance to the bactericidal activity of normal human serum. in this study, an interaction between the complement fluid phase regulator of the classical pathway, c4b binding protein (c4bp), and m. catarrhalis mutants lacking uspa1 and/or uspa2 was analyzed by flow cytometry and a ria. two clinical isolates of m. catarrhalis expressed uspa2 at a higher density than uspa1. the uspa1 mutants showed a decreased c4bp binding (37.6 ... | 2004 | 15383594 |
| detection rates of bacteria in chronic otitis media with effusion in children. | this study was performed to investigate polymerase chain reaction-based detection of bacterial dna in middle ear fluid and assess the correlation between the pcr-positive rate with several factors associated with middle ear effusion. the purpose was to gain a further understanding of bacterial infection as a major cause of otitis media with effusion. of the 278 specimens of middle ear fluid, 39 (14%) tested positive by ordinary culture. the overall detection rate of bacterial dna using the pcr m ... | 2004 | 15483353 |
| identification of a hemin utilization protein of moraxella catarrhalis (huma). | moraxella catarrhalis is a major cause of acute otitis media in young children and has also been implicated as an important cause of exacerbations in adults with underlying pulmonary disease. due to the considerable level of antibiotic resistance and the high degree of carriage rates in young children, it is likely that the incidence of m. catarrhalis infections will continue to rise. m. catarrhalis is a strict human respiratory pathogen, and this bacterium uses both transferrin and lactoferrin ... | 2004 | 15501773 |
| moraxella catarrhalis coaggregates with streptococcus pyogenes and modulates interactions of s. pyogenes with human epithelial cells. | the pathogens streptococcus pyogenes and moraxella catarrhalis colonize overlapping regions of the human nasopharynx. we have found that m. catarrhalis can dramatically increase s. pyogenes adherence to human epithelial cells and that species-specific coaggregation of these bacteria correlates with this enhanced adherence. | 2004 | 15501804 |
| activities of two novel macrolides, gw 773546 and gw 708408, compared with those of telithromycin, erythromycin, azithromycin, and clarithromycin against haemophilus influenzae. | the mic at which 50% of strains are inhibited (mic(50)) and the mic(90) of gw 773546, a novel macrolide, were 1.0 and 2.0 microg/ml, respectively, for 223 beta-lactamase-positive, beta-lactamase-negative, and beta-lactamase-negative ampicillin-resistant haemophilus influenzae strains. the mic(50)s and mic(90)s of gw 708408, a second novel macrolide, and telithromycin, an established ketolide, were 2.0 and 4.0 microg/ml, respectively, while the mic(50) and mic(90) of azithromycin were 1.0 and 2.0 ... | 2004 | 15504829 |
| a novel plasmid (pemcjh03) isolated from moraxella catarrhalis possibly useful as a cloning and expression vector within this species. | a preliminary screening study of six moraxella catarrhalis isolates from primary school children in the netherlands identified a small 3.5 kb plasmid (pemcjh03), containing four open reading frames, which encoded three mobilizing and one replicase protein. insertion of a kanamycin containing transposon (yielding pemcjh04) allowed selection and isolation of the plasmid in escherichia coli. natural transformation of pemcjh04 into m. catarrhalis was successful for 25% (3/12) of non-isogenic isolate ... | 2004 | 15848230 |
| in vitro pharmacodynamic activities of abt-492, a novel quinolone, compared to those of levofloxacin against streptococcus pneumoniae, haemophilus influenzae, and moraxella catarrhalis. | abt-492 is a novel quinolone with potent activity against gram-positive, gram-negative, and atypical pathogens, making this compound an ideal candidate for the treatment of community-acquired pneumonia. we therefore compared the in vitro pharmacodynamic activity of abt-492 to that of levofloxacin, an antibiotic commonly used for the treatment of pneumonia, through mic determination and time-kill kinetic analysis. abt-492 demonstrated potent activity against penicillin-sensitive, penicillin-resis ... | 2004 | 14693540 |
| antibacterial resistance among children with community-acquired respiratory tract infections (protekt 1999-2000). | to determine the susceptibility of bacterial respiratory tract pathogens, isolated from children (0-12 years) as part of the global protekt surveillance study (1999-2000), to a range of antibacterials, including the ketolide telithromycin. | 2004 | 14667791 |
| in vitro activities of da-7867, a novel oxazolidinone, against recent clinical isolates of aerobic and anaerobic bacteria. | in vitro activities of da-7867, a novel oxazolidinone, were compared to those of linezolid and commonly used antimicrobials. da-7867 had the lowest mic for 90% of the aerobic gram-positive bacterial strains tested, </=0.25 micro g/ml, and it was more potent than linezolid. | 2004 | 14693566 |
| topical ciprofloxacin/dexamethasone otic suspension is superior to ofloxacin otic solution in the treatment of children with acute otitis media with otorrhea through tympanostomy tubes. | to determine the efficacy and safety of topical ciprofloxacin/dexamethasone otic suspension compared with ofloxacin otic solution in the treatment of acute otitis media with otorrhea through tympanostomy tubes (aomt) in pediatric patients. | 2004 | 14702493 |
| adenoviral infections in children: the impact of rapid diagnosis. | adenovirus (adv) infections were difficult to diagnose in the past, and many infections were unrecognized. direct fluorescent assay (dfa) for the rapid diagnosis of adv infection, as part of a viral respiratory panel, became available at primary children's medical center (salt lake city, ut) in december 2000. | 2004 | 14702495 |
| septic arthritis caused by moraxella catarrhalis associated with infliximab treatment in a patient with undifferentiated spondarthritis. | 2004 | 14672904 | |
| granulocyte ceacam3 is a phagocytic receptor of the innate immune system that mediates recognition and elimination of human-specific pathogens. | carcinoembryonic antigen-related cell adhesion molecules (ceacams) are used by several human pathogens to anchor themselves to or invade host cells. interestingly, human granulocytes express a specific isoform, ceacam3, that participates together with ceacam1 and ceacam6 in the recognition of ceacam-binding microorganisms. here we show that ceacam3 can direct efficient, opsonin-independent phagocytosis of ceacam-binding neisseria, moraxella, and haemophilus species. ceacam3- but not ceacam6-medi ... | 2004 | 14707113 |
| microbiology of recurrent acute rhinosinusitis. | we undertook to evaluate the microbiology of recurrent acute rhinosinusitis. | 2004 | 14710008 |
| detection of the bacillus anthracis gyra gene by using a minor groove binder probe. | identification of chromosomal markers for rapid detection of bacillus anthracis is difficult because significant chromosomal homology exists among b. anthracis, bacillus cereus, and bacillus thuringiensis. we evaluated the bacterial gyra gene as a potential chromosomal marker for b. anthracis. a real-time pcr assay was developed for the detection of b. anthracis. after analysis of the unique nucleotide sequence of the b. anthracis gyra gene, a fluorescent 3' minor groove binding probe was tested ... | 2004 | 14715750 |
| use of real-time pcr to resolve slide agglutination discrepancies in serogroup identification of neisseria meningitidis. | neisseria meningitidis is a leading cause of bacterial meningitis and septicemia in children and young adults in the united states. rapid and reliable identification of n. meningitidis serogroups is crucial for judicious and expedient response to cases of meningococcal disease, including decisions about vaccination campaigns. from 1997 to 2002, 1,298 n. meningitidis isolates, collected in the united states through the active bacterial core surveillance (abcs), were tested by slide agglutination ... | 2004 | 14715772 |
| transferrin-binding protein b of neisseria meningitidis: sequence-based identification of the transferrin-binding site confirmed by site-directed mutagenesis. | a sequence-based prediction method was employed to identify three ligand-binding domains in transferrin-binding protein b (tbpb) of neisseria meningitidis strain b16b6. site-directed mutagenesis of residues located in these domains has led to the identification of two domains, amino acids 53 to 57 and 240 to 245, which are involved in binding to human transferrin (htf). these two domains are conserved in an alignment of different tbpb sequences from n. meningitidis and neisseria gonorrhoeae, ind ... | 2004 | 14729713 |
| antimicrobial resistance in the nasopharyngeal flora of children with acute maxillary sinusitis and maxillary sinusitis recurring after amoxicillin therapy. | to investigate the antimicrobial susceptibility of the organisms isolated from the nasopharynx of children who present with acute maxillary sinusitis (ams) or maxillary sinusitis that recurred (rms) after amoxicillin therapy. | 2004 | 14729759 |
| bro beta-lactamase alleles, antibiotic resistance and a test of the bro-1 selective replacement hypothesis in moraxella catarrhalis. | the hypothesis that bro-1 selectively replaced the bro-2 isoform of the moraxella catarrhalis bro beta-lactamase was tested by examining the temporal distribution, antibiotic resistance and epidemiological characteristics of isolates from a long-term collection at a single locale. | 2004 | 14729761 |
| pharmacokinetics of da-7867, a new oxazolidinone, after intravenous or oral administration to rats: intestinal first-pass effect. | pharmacokinetic parameters of da-7867 were dose independent after both intravenous administration and oral administration (at doses of 1 to 20 mg/kg of body weight) to rats. after oral administration of da-7867 to rats at a dose of 10 mg/kg, approximately 8.27% of oral dose was not absorbed from the gastrointestinal tract, f was 70.8%, and approximately 21.8% of the oral dose was eliminated by the intestine (intestinal first-pass effect). | 2004 | 14742232 |
| host-pathogen interaction during pneumococcal infection in patients with chronic obstructive pulmonary disease. | acute exacerbation is a frequent complication of chronic obstructive pulmonary disease (copd). recent studies suggested a role for bacteria such as streptococcus pneumoniae in the development of acute exacerbation. for this study, we investigated the following in copd patients: (i) the epidemiology of pneumococcal colonization and infection, (ii) the effect of pneumococcal colonization on the development of exacerbation, and (iii) the immunological response against s. pneumoniae. we cultured spu ... | 2004 | 14742525 |
| association of presence of aspergillus antibodies with hemoptysis in patients with old tuberculosis or bronchiectasis but no radiologically visible mycetoma. | old tuberculosis and bronchiectasis are the two most important causes of chronic structural changes of lungs in our locality. in the absence of radiologically visible mycetoma, the cause of hemoptysis in these two groups of patients is largely unknown. a 17-month prospective study was carried out to compare the prevalence of aspergillus fumigatus and aspergillus flavus antibodies in hemoptysis patients with old tuberculosis or bronchiectasis but no radiologically visible mycetoma (cases, n = 38) ... | 2004 | 14766834 |
| identification of bordetella pertussis in a critically ill human immunodeficiency virus-infected patient by direct genotypical analysis of gram-stained material and discrimination from b. holmesii by using a unique reca gene restriction enzyme site. | bordetella pertussis was diagnosed in a human immunodeficiency virus-infected patient by a newly developed method in which bacterial dna is amplified directly from sputum gram-stained slides. the validation of the method is described along with an additional new pcr-based assay that can distinguish between b. pertussis and bordetella holmesii. | 2004 | 14766870 |
| alloiococcus otitidis in acute otitis media. | the bacterium alloiococcus otitidis has been found to be associated with otitis media with effusion (ome). when the culture method is used, its detection rate is low, whereas applying the polymerase chain reaction (pcr) yields significantly higher frequencies. this study was carried out to investigate the incidence of a. otitidis in children with acute otitis media (aom). | 2004 | 14687687 |
| eustachian tube gland tissue changes are related to bacterial species in acute otitis media. | prior investigations have shown that the number of mucus producing goblet cells in the middle ear and eustachian tube (et) mucosa is highly increased during and up to at least six months after experimental acute otitis media (aom) caused by streptococcus pneumoniae (sp). further, the volume of the mucus producing paratubal gland components is increased up to 3 months after the acute infection. these changes may in conjunction with a deteriorated et function predispose a subsequent development of ... | 2004 | 14687693 |
| interactions between penicillin-binding proteins (pbps) and two novel classes of pbp inhibitors, arylalkylidene rhodanines and arylalkylidene iminothiazolidin-4-ones. | several non-beta-lactam compounds were active against various gram-positive and gram-negative bacterial strains. the mics of arylalkylidene rhodanines and arylalkylidene iminothiazolidin-4-ones were lower than those of ampicillin and cefotaxime for methicillin-resistant staphylococcus aureus mi339 and vancomycin-resistant enterococcus faecium ef12. several compounds were found to inhibit the cell wall synthesis of s. aureus and the last two steps of peptidoglycan biosynthesis catalyzed by ether- ... | 2004 | 14982790 |
| in vitro activities of the novel cephalosporin lb 11058 against multidrug-resistant staphylococci and streptococci. | lb 11058 is a novel parenteral cephalosporin with a c-3 pyrimidinyl-substituted vinyl sulfide group and a c-7 2-amino-5-chloro-1,3-thiazole group. this study evaluated the in vitro activity and spectrum of lb 11058 against 1,245 recent clinical isolates, including a subset of gram-positive strains with specific resistant phenotypes. lb 11058 was very active against streptococcus pneumoniae. the novel cephalosporin was 8- to 16-fold more potent than ceftriaxone, cefepime, or amoxicillin-clavulana ... | 2004 | 14693518 |
| peptide deformylase inhibitors as antibacterial agents: identification of vrc3375, a proline-3-alkylsuccinyl hydroxamate derivative, by using an integrated combinatorial and medicinal chemistry approach. | peptide deformylase (pdf), a metallohydrolase essential for bacterial growth, is an attractive target for use in the discovery of novel antibiotics. focused chelator-based chemical libraries were constructed and screened for inhibition of enzymatic activity, inhibition of staphylococcus aureus growth, and cytotoxicity. positive compounds were selected based on the results of all three assays. vrc3375 [n-hydroxy-3-r-butyl-3-(2-s-(tert-butoxycarbonyl)-pyrrolidin-1-ylcarbonyl)propionamide] was iden ... | 2004 | 14693547 |
| natural materno-fetal transfer of antibodies to pspa and to psaa. | pspa and psaa are streptococcus pneumoniae surface proteins and potential pneumococcal vaccine antigens. the aim of this study was to characterize the transplacental transfer of antibodies to pspa and to psaa. paired mother and cord blood sera were obtained at delivery from 28 women. concentrations of antibodies against pspa, psaa, tetanus toxoid (vaccine-induced antibodies) and p6-outer membrane protein (omp) of nontypeable haemophilus influenzae were determined by elisa. antibodies to pspa of ... | 2004 | 15008981 |
| association of clinical signs and symptoms with bacterial findings in acute otitis media. | in acute otitis media (aom), a means of prediction of the bacterial pathogen based on symptoms and signs would be valuable in selecting appropriate antimicrobial treatment. children in the control arm (n=831) in the finnish otitis media vaccine trial were prospectively observed in a study clinic setting from the age of 2 to 24 months. in patients with aom, myringotomy with aspiration was performed, and middle ear fluid samples were cultured for bacterial pathogens. symptoms and signs of respirat ... | 2004 | 14699456 |
| clinical and bacteriological efficacy of the ketolide telithromycin against isolates of key respiratory pathogens: a pooled analysis of phase iii studies. | a pooled analysis of data from 13 phase iii studies of telithromycin in the treatment of community-acquired pneumonia, acute exacerbations of chronic bronchitis, acute sinusitis or group a beta-haemolytic streptococcal pharyngitis and tonsillitis was undertaken. causative key respiratory tract pathogens (streptococcus pneumoniae, haemophilus influenzae, moraxella catarrhalis, staphylococcus aureus and streptococcus pyogenes) were isolated at entry to the studies from cultures of relevant respira ... | 2004 | 14706083 |
| structural basis for host recognition by the haemophilus influenzae hia autotransporter. | haemophilus influenzae is an important human pathogen that initiates infection by colonizing the upper respiratory tract. the h. influenzae hia autotransporter is an adhesive protein that promotes adherence to respiratory epithelial cells. hia adhesive activity resides in two homologous binding domains, called hiabd1 and hiabd2. these domains interact with the same host cell receptor, but bind with different affinities. in this report, we describe the crystal structure of the high-affinity hiabd ... | 2004 | 15029242 |
| the moraxella catarrhalis porin-like outer membrane protein cd is an adhesin for human lung cells. | the outer membrane protein cd (ompcd) of moraxella catarrhalis is an outer membrane protein with several attributes of a potential vaccine antigen. we isolated four transposon mutants of strain o35e on the basis of their reduced binding to a549 human lung cells in microcolony formation assays, and we determined that they contain a transposon in ompcd. we also found that these transposon insertions had pleiotropic effects: mutants grew slower, became serum sensitive, bound approximately 10-fold l ... | 2004 | 15039309 |
| neisseria meningitidis, neisseria lactamica and moraxella catarrhalis share cross-reactive carbohydrate antigens. | carriage of commensal bacteria species is associated with the development of natural immunity to meningococcal disease, with lipo-oligosaccharides (los) of meningococci being one of the main virulence factors associated with severity of meningococcal disease. meningococcal reference strains and isolates from the commensal species neisseria lactamica and moraxella catarrhalis were assessed for the presence of cross-reactive glycoconjugate antigens. binding of human blood group antibodies of the p ... | 2004 | 15040943 |
| fatty acid biosynthesis as a target for novel antibacterials. | the bacterial fatty acid synthesis pathway has significant potential as a target for the development of novel antibacterials. the pathway has been extensively studied in escherichia coli, the crystal structures of the compounds involved are known and homologous genes are readily identified in the genomes of important pathogens. the currently used drugs triclosan and isoniazid are known to target one step in the pathway. other experimental compounds such as thiolactomycin and cerulenin effectivel ... | 2004 | 15043388 |
| eradication of streptococcus pneumoniae in the nasopharyngeal flora of children with acute otitis media after amoxicillin-clavulanate therapy. | nasopharyngeal cultures were obtained from 60 children with acute otitis media before and after treatment with either 45 or 90 mg of amoxicillin (given as amoxicillin-clavulanate) per kg of body weight per day for 10 days. the number of streptococcus pneumoniae isolates in the 45-mg/kg group was reduced from 12 to 6 and was reduced from 14 to 1 (p = 0.0261) in the 90-mg/kg group. | 2004 | 15047558 |
| comparative in vitro activity of telithromycin against macrolide-resistant and -susceptible streptococcus pneumoniae, moraxella catarrhalis and haemophilus influenzae. | the first objective was to investigate the in vitro activity of telithromycin against respiratory tract pathogens in comparison with other antimicrobial agents. the second objective was to identify the influence of the erm(b) and mef(a) genes on the susceptibility of streptococcus pneumoniae to telithromycin. | 2004 | 15056640 |
| comparative study of the in vitro activity of a new fluoroquinolone, abt-492. | the in vitro activity of a new fluoroquinolone, abt-492, was determined. | 2004 | 15056651 |
| moraxella catarrhalis bacteraemia in an immunocompetent patient in lahore, pakistan. | 2004 | 15058742 | |
| analysis of moraxella catarrhalis outer membrane antigens cross-reactive with neisseria meningitidis and neisseria lactamica. | mouse sera against outer membrane proteins from moraxella catarrhalis, neisseria meningitidis and neisseria lactamica, and human sera from both healthy individuals and patients convalescing from meningococcal meningitis were used to identify cross-reactive antigens. mouse anti-n. meningitidis and anti-n. lactamica sera recognized 77, 62 and 32 kda outer membrane antigens in m. catarrhalis strains; on the contrary, the meningococcal porin porb (38-42 kda) was recognized by one of the two anti-m. ... | 2004 | 14734192 |
| real-time multiplex pcr assay for detection of brucella spp., b. abortus, and b. melitensis. | the identification of brucella can be a time-consuming and labor-intensive process that places personnel at risk for laboratory-acquired infection. here, we describe a real-time pcr assay for confirmation of presumptive brucella isolates. the assay was designed in a multiplex format that will allow the rapid identification of brucella spp., b. abortus, and b. melitensis in a single test. | 2004 | 15004098 |
| iron transport systems in neisseria meningitidis. | acquisition of iron and iron complexes has long been recognized as a major determinant in the pathogenesis of neisseria meningitidis. in this review, high-affinity iron uptake systems, which allow meningococci to utilize the human host proteins transferrin, lactoferrin, hemoglobin, and haptoglobin-hemoglobin as sources of essential iron, are described. classic features of bacterial iron transport systems, such as regulation by the iron-responsive repressor fur and tonb-dependent transport activi ... | 2004 | 15007100 |
| effect of moxifloxacin on bacterial pathogenicity factors in comparison with amoxicillin, clarithromycin and ceftriaxone. | moxifloxacin is a recent fluoroquinolone with an antibacterial spectrum encompassing both aerobic gram-negative and gram-positive strains, as well as anaerobic bacteria. in this study the activity of moxifloxacin against streptococcus pneumoniae, staphylococcus aureus, moraxella catarrhalis, haemophilus influenzae, escherichia coli, proteus mirabilis and pseudomonas aeruginosa, and effects of subinhibitory concentrations on bacterial morphology and adhesion properties were compared with those of ... | 2004 | 15077996 |
| haemophilus influenzae: genetic variability and natural selection to identify virulence factors. | 2004 | 15102751 | |
| survival of streptococcus pneumoniae, haemophilus influenzae, and moraxella catarrhalis frozen in skim milk- tryptone-glucose-glycerol medium. | in stgg (skim milk, tryptone, glucose, glycerol) medium at -80 degrees c, streptococcus pneumoniae, haemophilus influenzae, and moraxella catarrhalis isolates survived for at least 3 years, and the same species have survived in nasopharyngeal swabs for at least 1.5 years. at -20 degrees c, s. pneumoniae and m. catarrhalis survived for 1.5 years, but h. influenzae survived for only 2 months. | 2004 | 14715793 |
| photodynamic therapy: a new antimicrobial approach to infectious disease? | photodynamic therapy (pdt) employs a non-toxic dye, termed a photosensitizer (ps), and low intensity visible light which, in the presence of oxygen, combine to produce cytotoxic species. pdt has the advantage of dual selectivity, in that the ps can be targeted to its destination cell or tissue and, in addition, the illumination can be spatially directed to the lesion. pdt has previously been used to kill pathogenic microorganisms in vitro, but its use to treat infections in animal models or pati ... | 2004 | 15122361 |
| augmentin (amoxicillin/clavulanate) in the treatment of community-acquired respiratory tract infection: a review of the continuing development of an innovative antimicrobial agent. | amoxicillin/clavulanate (augmentin) is a broad-spectrum antibacterial that has been available for clinical use in a wide range of indications for over 20 years and is now used primarily in the treatment of community-acquired respiratory tract infections. amoxicillin/clavulanate was developed to provide a potent broad spectrum of antibacterial activity, coverage of beta-lactamase-producing pathogens and a favourable pharmacokinetic/pharmacodynamic (pk/pd) profile. these factors have contributed t ... | 2004 | 14726431 |
| [resistance surveillance of common community respiratory pathogens isolated in china, 2002 - 2003]. | to investigate antimicrobial resistance of common community respiratory pathogens isolated in china, 2002 - 2003. | 2004 | 15130324 |
| in vitro activity of abt773, a new ketolide derivative exhibiting innovative microbiological properties against well-characterised antibiotic resistant pathogens in italy. | the in vitro activity of abt773, a new ketolide, was assessed against a collection (518) of well-characterised gram-positive and gram-negative pathogens and compared with that of other appropriate drugs. abt773 was active (mic-90=0.03 mg/l) against the staphylococci tested which included macrolide-resistant but clindamycin susceptible organisms. streptococcus pneumoniae, s. pyogenes and s. agalactiae were also inhibited (mic-90 range: <0.0075-0.5mg/l) irrespective of their antibiotic resistance ... | 2004 | 14732308 |
| relationship among peripheral leukocyte counts, etiologic agents and clinical manifestations in acute otitis media. | to analyze the peripheral leukocyte counts of children with acute otitis media (aom) in relation to etiology, age, clinical symptoms and signs, prior antibiotic treatment, previous aom history and pathogen eradication during antibiotic therapy. | 2004 | 15131462 |
| protekt 1999-2000: a multicentre study of the antibiotic susceptibility of respiratory tract pathogens in hong kong, japan and south korea. | a multicentre surveillance study performed in the far east during 1999-2000 investigated the in vitro activity of >20 antibacterials against common respiratory pathogens. in hong kong, japan, and south korea, 57.1, 44.5 and 71.5% streptococcus pneumoniae were penicillin-resistant and 71.4, 77.9 and 87.6% were erythromycin-resistant, respectively. overall, >90% of penicillin-resistant strains were also macrolide-resistant. all strains were susceptible to telithromycin. fluoroquinolone-resistant i ... | 2004 | 14732313 |
| antibiotics ge23077, novel inhibitors of bacterial rna polymerase. i. taxonomy, isolation and characterization. | ge 23077 factors a1, a2, b1 and b2 are novel antibiotics isolated from fermentation broths of an actinomadura sp. strain. ge23077 antibiotics are cyclic peptides, which inhibit escherichia coli rna polymerase at nm concentrations. both rifampicin-sensitive and rifampicin-resistant polymerases are inhibited, whereas e. coli dna polymerase and wheat germ rna polymerase are substantially not affected. in spite of the potent activity on the enzyme, the antibiotics generally show poor activity agains ... | 2004 | 15152807 |
| distribution and shifting trends of bacterial keratitis in north china (1989-98). | to study the distribution and shifting trends of bacterial keratitis. | 2004 | 14736761 |
| new class of bacterial phenylalanyl-trna synthetase inhibitors with high potency and broad-spectrum activity. | phenylalanyl (phe)-trna synthetase (phe-rs) is an essential enzyme which catalyzes the transfer of phenylalanine to the phe-specific transfer rna (trna(phe)), a key step in protein biosynthesis. phenyl-thiazolylurea-sulfonamides were identified as a novel class of potent inhibitors of bacterial phe-rs by high-throughput screening and chemical variation of the screening hit. the compounds inhibit phe-rs of escherichia coli, haemophilus influenzae, streptococcus pneumoniae, and staphylococcus aure ... | 2004 | 14742205 |
| role of transferrin receptor from a neisseria meningitidis tbpb isotype ii strain in human transferrin binding and virulence. | neisseria meningitidis acquires iron through the action of the transferrin (tf) receptor, which is composed of the tf-binding proteins a and b (tbpa and tbpb). meningococci can be classified into isotype i and ii strains depending on whether they harbor a type i or ii form of tbpb. both types of tbpb have been shown to differ in their genomic, biochemical, and antigenic properties. here we present a comparative study of isogenic mutants deficient in either or both tbps from the isotype i strain ... | 2004 | 15155653 |
| building in efficacy: developing solutions to combat drug-resistant s. pneumoniae. | the development of our understanding of the pharmacokinetic (pk) and pharmacodynamic (pd) principles that determine antimicrobial efficacy has advanced substantially over the last 10 years. we are now in a position to use pk/pd principles to set targets for antimicrobial design and optimisation so that we can predict eradication of specific pathogens or resistant variants when agents are used clinically. optimisation of pk/pd parameters to enable the treatment of resistant pathogens with oral ag ... | 2004 | 14759230 |
| the yersinia adhesin yada collagen-binding domain structure is a novel left-handed parallel beta-roll. | the crystal structure of the recombinant collagen-binding domain of yersinia adhesin yada from yersinia enterocolitica serotype o:3 was solved at 1.55 a resolution. the trimeric structure is composed of head and neck regions, and the collagen binding head region is a novel nine-coiled left-handed parallel beta-roll. before the beta-roll, the polypeptide loops from one monomer to the rest, and after the beta-roll the neck region does the same, making the transition from the globular head region t ... | 2004 | 14765110 |
| [a retrospective analysis of community-acquired pneumonia between 2000 and 2002 in a community hospital]. | we previously reported a hospital-based retrospective study on community-acquired pneumonia (cap) at tagami hospital, which was a community hospital, between 1994 and 1997. this study was designed to clarify the etiology of cap diagnosed between 2000 and 2002. we analyzed a total of 124 cases of cap in our hospital during the study period, and compared the results with the previous data. identification of the causative organisms of cap was based on gram staining, the morphology of the colonies, ... | 2004 | 14768367 |
| activity of oral antibiotics against respiratory tract pathogens in spain. | the aim of this study was to carry out a nationwide survey to assess the susceptibility of clinical isolates of four respiratory pathogens against nine antibiotics. eight spanish centers participated in the study, collecting a total of 977 isolates of streptococcus pneumoniae, streptococcus pyogenes, haemophilus influenzae and moraxella catarrhalis. the susceptibility of s. pneumoniae to penicillin was 37.46% susceptible, 30.43% intermediate and 32.11% resistant. mic(90) of all antibiotics again ... | 2003 | 14961138 |
| pseudomonal infections in patients with copd: epidemiology and management. | copd is a common disease with increasing prevalence. the chronic course of the disease is characterized by acute exacerbations that cause significant worsening of symptoms. bacterial infections play a dominant role in approximately half of the episodes of acute exacerbations of copd. the importance of pseudomonal infection in patients with acute exacerbations of copd stems from its relatively high prevalence in specific subgroups of these patients, and particularly its unique therapeutic ramific ... | 2003 | 14719985 |
| [susceptibilities of bacteria isolated from patients with lower respiratory infectious diseases to antibiotics (2001)]. | from october 2001 to september 2002, we collected the specimen from 370 patients with lower respiratory tract infections in 16 institutions in japan, and investigated the susceptibilities of the isolated bacteria to various antibacterial agents and antibiotics and patients' characteristics. of 458 strains that were isolated from specimen (mainly from sputum) and assumed to be bacteria causing in inflammation, 456 strains were investigated. the breakdown of the isolated bacteria were: staphylococ ... | 2003 | 14692377 |
| does the tonsillar surface flora differ in children with and without tonsillar disease? | to investigate whether the tonsillar flora differ in children with and without adenotonsillar disease. | 2003 | 14575405 |
| comparison of bsac agar dilution and nccls broth microdilution mic methods for in vitro susceptibility testing of streptococcus pneumoniae, haemophilus influenzae and moraxella catarrhalis: the bsac respiratory resistance surveillance programme. | the aim of this study was to establish the degree of comparability between the nccls broth microdilution and bsac agar dilution mic methods of antimicrobial susceptibility testing. | 2003 | 14585864 |
| mucosal immunization against respiratory bacterial pathogens. | bacterial respiratory diseases remain a major cause of morbidity and mortality throughout the world. the young and the elderly are particularly susceptible to the pathogens that cause these diseases. therapeutic approaches remain dependent upon antibiotics contributing to the persistent increases in antibiotic resistance. the main causes of respiratory disease discussed in this review are mycobacterium tuberculosis, corynebacterium diphtheriae, bordatella pertussis, streptococcus pneumoniae, non ... | 2003 | 14711339 |
| microbiology of otitis media in costa rican children, 1999 through 2001. | because of the increasing number of resistant middle ear pathogens and the impact of the new conjugate streptococcus pneumoniae vaccine, an active surveillance of the microbiology and susceptibility pattern of middle ear pathogens is required. | 2003 | 14688566 |
| [activities of antimicrobial agents against 8,474 clinical isolates obtained from 37 medical institutions during 2000 in japan]. | a survey was conducted to determine the antimicrobial activity of fluoroquinolones and other antimicrobial agents against 8,474 clinical isolates obtained from 37 japanese medical institutions in 2000. a total of 25 antimicrobial agents were used, comprising 4 fluoroquinolones, 13 beta-lactams, minocycline, chloramphenicol, clarithromycin, azithromycin, gentamicin, amikacin, sulfamethoxazole-trimethoprim, and vancomycin. a high resistance rate of over 85% against fluoroquinolones was exhibited b ... | 2003 | 14692376 |
| in vitro activity of telithromycin compared with macrolides and fluoroquinolones against streptococcus pneumoniae, haemophilus influenzae and moraxella catarrhalis. | the in vitro activity of telithromycin was compared with erythromycin a, azithromycin, clarithromycin, moxifloxacin, gemifloxacin, levofloxacin, ciprofloxacin, penicillin g, ampicillin, cefuroxime and ceftriaxone against 336 consecutive strains (83 streptococcus pneumoniae, 168 haemophilus influenzae and 85 moraxella catarrhalis) isolated from patients with community-acquired respiratory tract infections. telithromycin (mic(90), 0.008 mg/l) was the most active drug against s. pneumoniae. telithr ... | 2003 | 14602368 |
| presumed endocarditis caused by bro beta-lactamase-producing moraxella lacunata in an infant with fallot's tetrad. | a case of presumed endocarditis caused by moraxella lacunata in a 15-month-old male infant with fallot's tetrad is described. this infection may have occurred as the result of transmission of this organism between the father and his son. this is the first report of bro beta-lactamase-producing m. lacunata causing presumed endocarditis. | 2003 | 14605192 |
| a mouse model for acute otitis media. | to induce acute otitis media in the mouse and to describe the clinical and bacteriological course of the infection, middle ears of balb/c, swiss-webster and c57bl/6 mice were inoculated with streptococcus pneumoniae, haemophilus influenzae and moraxella catarrhalis. systemic and local changes were monitored by clinical observations, otomicroscopy, and analysis of bacterial samples from blood and middle ears. agglutination of mouse erythrocytes by m. catarrhalis was also tested. depending on bact ... | 2003 | 14616553 |
| factors contributing to hydrogen peroxide resistance in streptococcus pneumoniae include pyruvate oxidase (spxb) and avoidance of the toxic effects of the fenton reaction. | aerobic growth of streptococcus pneumoniae results in production of amounts of hydrogen peroxide (h(2)o(2)) that may exceed 1 mm in the surrounding media. h(2)o(2) production by s. pneumoniae has been shown to kill or inhibit the growth of other respiratory tract flora, as well as to have cytotoxic effects on host cells and tissue. the mechanisms allowing s. pneumoniae, a catalase-deficient species, to survive endogenously generated concentrations of h(2)o(2) that are sufficient to kill other ba ... | 2003 | 14617646 |
| new antibacterial tetrahydro-4(2h)-thiopyran and thiomorpholine s-oxide and s,s-dioxide phenyloxazolidinones. | combinatorial libraries of n-acylated 5-(s)-aminomethyloxazolidinone derivatives of s-oxide and s,s-dioxide tetrahydro-4(2h)-thiopyranyl and thiomorpholine phenyloxazolidinone series have been synthesized on a solid phase and evaluated for antimicrobial activity. several novel potent leads have been identified, including orally active oxazolidinones with enhanced activity against respiratory tract infection pathogens haemophilus influenzae and moraxella catarrhalis. | 2003 | 14623003 |
| antimicrobial susceptibility of lower respiratory tract pathogens in great britain and ireland 1999-2001 related to demographic and geographical factors: the bsac respiratory resistance surveillance programme. | the aim of this study was to assess the antimicrobial susceptibility of community-acquired lower respiratory pathogens in great britain and ireland, and investigate its relationship with demographic and geographical factors using multiple logistic regression analysis. | 2003 | 14585865 |
| contemporary evaluation of the in vitro activity and spectrum of cefdinir compared with other orally administered antimicrobials tested against common respiratory tract pathogens (2000-2002). | cefdinir is an oral cephalosporin approved by the food and drug administration in 1997 for the treatment of acute exacerbation of chronic bronchitis, pharyngitis-tonsillitis, community-acquired pneumonia, acute maxillary sinusitis, and uncomplicated skin and skin structure infections in adults and adolescents, and acute otitis media, pharyngitis-tonsillitis, and uncomplicated skin and skin structure infections in children. although cefdinir showed similar activity to other cephalosporins in the ... | 2003 | 14596971 |
| prevention and management of antibacterial resistance for primary care patients with respiratory tract infections. | this review examines the problem of increasing antibacterial resistance among the pathogens commonly associated with community-acquired respiratory tract infections, particularly streptococcus pneumoniae, haemophilus influenzae, and moraxella catarrhalis. the increases in morbidity, mortality, and treatment cost associated with increased resistance to available antibiotics are challenging prescribers to find more effective therapeutic strategies. a medline search of the literature from 1966 to t ... | 2003 | 14570346 |
| identification of a 3-deoxy-d-manno-octulosonic acid biosynthetic operon in moraxella catarrhalis and analysis of a kdsa-deficient isogenic mutant. | lipooligosaccharide (los), a predominant surface-exposed component of the outer membrane, has been implicated as a virulence factor in the pathogenesis of moraxella catarrhalis infections. however, the critical steps involved in the biosynthesis and assembly of m. catarrhalis los currently remain undefined. in this study, we used random transposon mutagenesis to identify a 3-deoxy-d-manno-octulosonic acid (kdo) biosynthetic operon in m. catarrhalis with the gene order pyrg-kdsa-eno. the lipid a- ... | 2003 | 14573664 |
| amoxicillin/clavulanate potassium extended release tablets: a new antimicrobial for the treatment of acute bacterial sinusitis and community-acquired pneumonia. | community-acquired bacterial respiratory tract infections are among the most common health disorders requiring medical care and are associated with substantial morbidity, mortality, and direct and indirect costs. recent increases in the prevalence of antimicrobial resistance have resulted in reduced susceptibility of the most common respiratory tract bacterial pathogens to a number of antimicrobials. amoxicillin/clavulanate potassium extended release (er) tablets (augmentin xr, glaxosmithkline) ... | 2003 | 14521493 |
| detection of a point mutation associated with high-level isoniazid resistance in mycobacterium tuberculosis by using real-time pcr technology with 3'-minor groove binder-dna probes. | tuberculosis remains one of the leading infectious causes of death worldwide. the emergence of drug-resistant strains of mycobacterium tuberculosis is a serious public health threat. resistance to isoniazid (inh) is the most prevalent form of resistance in m. tuberculosis and is mainly caused by mutations in the catalase peroxidase gene (katg). among high-level inh-resistant isolates (mic > or = 2), 89% are associated with a mutation at codon 315 of katg. there is a need to develop rapid diagnos ... | 2003 | 14532194 |
| macrolide resistance: an increasing concern for treatment failure in children. | antimicrobial treatment of pediatric respiratory tract infections has evolved during the past 30 years as a result of antimicrobial resistance. the focus of antimicrobial therapy in these conditions has shifted from penicillins to other agents because of the dramatic increase in antimicrobial resistance among common respiratory pathogens, including streptococcus pneumoniae, haemophilus influenzae and moraxella catarrhalis. it is important for clinicians to understand how resistance develops so t ... | 2003 | 14566999 |
| [administration of acute exacerbation of chronic obstructive pulmonary disease]. | we have to consider the exacerbation of chronic obstructive pulmonary disease(copd) may be caused not only by infection, but also by acute exacerbation of chronic heart failure, pulmonary embolism, pneumothorax, or other cardiopulmonary complications. because it is characteristic that the exacerbation of copd is often recurensive, the most important thing is the administration during stable status. approximately 40% of pathogens of the acute infectious exacerbation of copd are haemophilus influe ... | 2003 | 14674328 |
| current issues in the management of bacterial respiratory tract disease: the challenge of antibacterial resistance. | the worldwide burden of respiratory tract disease is enormous. resistance to penicillins, macrolides, and cephalosporins is now detected among the leading bacterial pathogens that cause respiratory tract infections (rtis)-streptococcus pneumoniae, haemophilus influenzae, and moraxella catarrhalis. the increasing role of atypical/intracellular pathogens (eg, chlamydia pneumoniae, mycoplasma pneumoniae, legionella pneumophila) in rtis, as well as their increase in antibiotic resistance prevalence, ... | 2003 | 14671500 |
| the future prospects of oxazolidinones. | the high rates of antimicrobial resistance seen among many gram-positive pathogens means that there is an ongoing need for new antibacterial drugs. currently, several pharmaceutical companies are investigating compounds belonging to a new class of anti-gram-positive agents, the oxazolidinones, one member of which, linezolid, is licensed for clinical use. interest in oxazolidinones is being stimulated by the results of recent trials demonstrating the excellent clinical efficacy of linezolid in a ... | 2003 | 12789613 |
| human immune response to outer membrane protein cd of moraxella catarrhalis in adults with chronic obstructive pulmonary disease. | moraxella catarrhalis is a common cause of lower respiratory tract infection in adults with chronic obstructive pulmonary disease (copd). the antibody response to outer membrane protein (omp) cd, a highly conserved surface protein of m. catarrhalis under consideration as a vaccine antigen, was studied in adults with copd following 40 episodes of infection or colonization. following infection or colonization, 9 of 40 patients developed new serum immunoglobulin g (igg) to omp cd, as measured by en ... | 2003 | 12595444 |
| bacteriologic and clinical efficacy of high dose amoxicillin for therapy of acute otitis media in children. | high dose (70 to 90 mg/kg/day) amoxicillin is recommended as first line therapy of acute otitis media (aom) in geographic areas where drug-resistant streptococcus pneumoniae is prevalent. information on the bacteriologic efficacy of high dose amoxicillin treatment for aom is limited. | 2003 | 12792379 |
| in vitro activity of s-3578, a new broad-spectrum cephalosporin active against methicillin-resistant staphylococci. | the in vitro antibacterial activity of s-3578, a new parenteral cephalosporin, against clinical isolates was evaluated. the mics of the drug at which 90% of the isolates were inhibited were 4 micro g/ml for methicillin-resistant staphylococcus aureus (mrsa) and 2 micro g/ml for methicillin-resistant staphylococcus epidermidis, which were fourfold higher than and equal to those of vancomycin, respectively. the anti-mrsa activity of s-3578 was considered to be due to its high affinity for penicill ... | 2003 | 12604523 |
| detection and identification of bartonella species pathogenic for humans by pcr amplification targeting the riboflavin synthase gene (ribc). | several bartonella species have now been implicated as human pathogens. the recovery of these fastidious organisms in the clinical microbiology laboratory remains difficult, and current methods are still relatively insensitive. thus, the bartonellae are good candidates for detection by pcr. we have developed a pcr assay which uses a single primer pair targeting the riboflavin synthase gene (ribc) and detected six bartonella species that have been implicated in human disease, b. henselae, b. quin ... | 2003 | 12624031 |
| activity of nine oral agents against gram-positive and gram-negative bacteria encountered in community-acquired infections: use of pharmacokinetic/pharmacodynamic breakpoints in the comparative assessment of beta-lactam and macrolide antimicrobial agents. | the application of pharmacokinetic (pk) and pharmacodynamic (pd) data in conjunction with minimum inhibitory concentrations (mics) of antibacterial agents has been shown to allow for improved selection and appropriate dosing of antimicrobial agents for specific infections, increasing the likelihood of bacteriologic cure and, through this, reducing the risk for the development of resistant organisms. | 2003 | 12637118 |
| bacterial aetiology of non-resolving otitis media in south african children. | little is known of the aetiology, serotypes or susceptibility of the pathogens causing non-resolving otitis media in children receiving care from specialists in private practice in developed or in developing countries. increased access to antibiotics in the community amongst children receiving such private care in south africa may be anticipated to lead to levels of resistance similar to those found in countries with similar models of private practice, such as the united states. this study was c ... | 2003 | 12648369 |
| pharmacokinetics and efficacy of linezolid in a gerbil model of streptococcus pneumoniae-induced acute otitis media. | the oxazolidinone linezolid represents a new antibacterial class of potential benefit in managing multidrug-resistant gram-positive infections, including those caused by streptococcus pneumoniae. in a gerbil model of acute otitis media (aom) induced by either penicillin-resistant s. pneumoniae (prsp; amoxicillin mic = 8 micro g/ml, linezolid mic = 1 micro g/ml) or penicillin-susceptible s. pneumoniae (pssp; amoxicillin mic = 0.015 micro g/ml, linezolid mic = 1 micro g/ml), we explored the plasma ... | 2003 | 12654670 |
| genetic characterization of fluoroquinolone-resistant streptococcus pneumoniae strains isolated during ciprofloxacin therapy from a patient with bronchiectasis. | five spain(9v-3) streptococcus pneumoniae strains were isolated from a patient with bronchiectasis who had received long-term ciprofloxacin therapy. one ciprofloxacin-susceptible strain was isolated before treatment, and four ciprofloxacin-resistant strains were isolated during treatment. the resistant strains were derived from the susceptible strain either by a parc mutation (low-level resistance) or by parc and gyra mutations (high-level resistance). this study shows that ciprofloxacin therapy ... | 2003 | 12654682 |
| detection of helicobacter pylori in gastric mucosa of patients with gastroduodenal diseases by pcr-restriction analysis using the rna polymerase gene (rpob). | a novel pcr restriction analysis method using the rna polymerase beta-subunit- coding gene (rpob) was employed to both detect and identify helicobacter pylori in biopsy specimens and culture isolates. the rpob dnas (458 bp) were specifically amplified by pcr with the helicobacter-specific primers (hf and hr). based on the determined rpob sequences of the culture isolates, an h. pylori-specific restriction site, tru9i, was found. h. pylori can be identified by observing two discernible dna fragme ... | 2003 | 12843100 |
| in vitro activity of a new antibiotic, nvp-pdf386 (vrc4887), against chlamydia pneumoniae. | the in vitro activity of nvp-pdf386 (vrc4887), a novel new peptide deformylase inhibitor, and those of levofloxacin and clarithromycin were tested against 21 isolates of chlamydia pneumoniae. the mic at which 90% of the isolates were inhibited and the minimal bactericidal concentration at which 90% of the isolates were killed by nvp-pdf386 for all isolates of c. pneumoniae were 0.008 micro g/ml (range, 0.008 to 0.015 micro g/ml) compared to 0.25 and 0.06 micro g/ml for levofloxacin and clarithro ... | 2003 | 12654690 |
| inactivation of the moraxella catarrhalis 7169 ferric uptake regulator increases susceptibility to the bactericidal activity of normal human sera. | moraxella catarrhalis is a strict human pathogen and a significant cause of respiratory disease and otitis media. in direct response to these infections, research efforts have focused primarily on the identification of potential vaccine targets. the general biology of m. catarrhalis, however, including the mechanisms utilized to survive in the human host, remains poorly understood. previous work has demonstrated that m. catarrhalis expresses iron-repressible proteins, suggesting the presence of ... | 2003 | 12654799 |
| bacterial lactoferrin-binding protein a binds to both domains of the human lactoferrin c-lobe. | pathogenic bacteria in the family neisseriaceae express surface receptors to acquire iron from the mammalian iron-binding proteins. transferrins and lactoferrins constitute a family of iron-binding proteins highly related in both sequence and structure, yet the bacterial receptors are able to distinguish between these proteins and uphold a strict binding specificity. in order to understand the molecular basis for this specificity, the interaction between human lactoferrin (hlf) and the lactoferr ... | 2003 | 12855724 |