Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| serum thyroid hormones and thyrotropin in anorexia nervosa. | sixteen patients with typical signs and symptoms of anorexia nervosa were studied with measurement of serum thyroxine (t4), triiodothyronine (t3) and thyrotropin (tsh), both baseline and stimulated by thyrotropin-releasing hormone (trh). the results of the patients were compared with those of 16 normal control subjects. serum t4 (5.8 plus or minus 0.26 mug/100 ml, mean plus or minus se) and t3 (82 plus or minus 5.7 ng/100 ml) of patients with anorexia nervosa were significantly (p less than 0.00 ... | 1975 | 804141 |
| thyrotropin-releasing hormone secretory physiology: studies by radioimmunoassay and affinity chromatography. | thyrotropin-releasing hormone (trh) in rat blood and mathanol extracts of hypothalami has been quantified by a specific trh radioimmunoassay, in conjunction with trh affinity chromatography. blood trh was found to be elevated dramatically after 1 h by the physiologic stimulus, ambient cold (4 c), which was also attended by a 2-fold rise in serum thyrotropin (tsh). the acute administration of parenteral triodothyronine (t3) over a period of 48 h prior to identical cold exposure completely abolish ... | 1975 | 805042 |
| familial thyroxine-binding globulin deficiency in a patient with congenital hypothyroidism. | a kindred with deficiency of thyroxine binding globulin (tbg) was presented. the propositus, a 1-year old female also had congenital hypothyroidism with ectopic (sublingual) thyroid. decrease in tbg-binding capacity (tbg) values ranging from 1.2-10.2 mug/100 ml) was detected in the seven relatives on the maternal side. of these subject 2 were male and 5 female; the males had the lowest binding capacities. but six members of paternal relatives were entirely normal in this respect. the mode of inh ... | 1975 | 805043 |
| propylthiouracil blocks extrathyroidal conversion of thyroxine to triiodothyronine and augments thyrotropin secretion in man. | propylthiouracil (ptu) inhibits peripheral deiodination of thyroxine (t4) and triiodothyronine (t3) and decreases the metabolic effectiveness of t4 in animals. to assess the effect of ptu on extrathyroidal conversion of t4 to t3 in man, 15 studies were performed in athyreotic patients treated with 100 or 200 mug of l-t4 daily for 1 mo before the addition of ptu, 250 mg every 6 h for 8 days. serum t3, t4, and thyrotropin (tsh) were measured daily by radioimmunoassay; serum tsh response to 500-mu ... | 1975 | 805160 |
| excessive thyrotropin concentrations in the circulation of the spontaneously hypertensive rat. | thyroid funct-on in shr was compared to that of inbred normotensive wistar rats from kyoto, and random bred wistar rats from the united states. a marked increase in circulating thyrotropin concentration was found in shr compared to controls. serum thyroxine and t3 concentrations relative to controls, however, were variable and the concentrations in male and female shr relative to kyoto controls did not correspond with each other. no ready explanation for the circulating excess of thyrotropin, w ... | 1975 | 805436 |
| dorsal root afferents to clarke's column from hindlimb cord levels in tupaia and galago. | the projection of hindlimb dorsal root afferents to clarke's column has been studied in the tree shrew (tupaia glis) and lesser bushbaby (galago senegalensis). in the bushbaby, fibers from k12, l1 and l3 projected ipsilaterally to clark's nucleus from levels l3 to t3, l2 to t4 and l3 to t5 respectively. in tupaia, afferents from t11, l1, and l3 terminated ipsilaterally within the nucleus from segments l2 to t4, l3 to t6, and l3 to t8. fibers from t12, l1, and l3 in galago and t11 in tupaia termi ... | 1975 | 805631 |
| the trh test in the course of treatment of hyperthyroidism. | in nine patients with thyrotoxicosis (three patients with ophthalmopathy, one patient with t3 thyrotoxicosis) we followed plasma levels of triiodothyronine (t3) and thyroxine (t4) and the trh induced tsh release before and under treatment with propythiouracil (ptu), carbimazole or methimazol. the patients were observed for 2-8 months and did not receive any thyroid hormones during this time. before treatment the tsh responses to trh were absent in all patients. after commencement of antithyroid ... | 1975 | 805680 |
| variations of rat thyroid activity during exposure to high environmental temperature (34 degrees c). relation between hypothalamic pituitary and thyroid hormone levels. | changes in thyroid activity and variations in the hypthalamo-pituitary-thyroid hormone levels were examined in rats exposed to heat (34 degrees c)for3 weeks. thyroid activity evaluated histologically (epithelium/colloid ratio, nuclear size) by radioiodine exploration (24 hrs 125 i uptake, ratio of mono- to di-125 iodotyrosines - mit/dit, ratio of tri- to tetra-125 iodothyronines-t3/t4, and plasma 125i-t4 and assay of plasma t4, evolves in a triphasic manner. 1.a depression phase between day 0 a ... | 1975 | 806054 |
| [when is a radioisotope diagnosis indicated in thyroid diseases and when is it superfluous?]. | in response to the question when radioactive isotopes (radionuclides) are necessary or superfluous in the diagnostic workup of thyroid disease, the following observations can be made: 1. radionuclides are almost ubiquitously used for the specific and relevant in-vitro tests for measuring the circulating thyroid hormones (t4 und t3, etc.) and necessitate a very small quantity of serum. they lead in approximately 90% of cases of the correct diagnosis, especially when supported by careful clinical ... | 1975 | 806113 |
| [treatment possibilities of laryngeal cancer. surgery--radiotherapy--chemotherapy]. | treatment's possibilities of the carcinoma of larynx are presented and we especially attract notice to require a right distribution of stages in conformity with the prescriptions from the u.i.c.c. operation's methods and radiotherapeutic possibilities are indicated. following the author's views, it would be made primary irradiations in the stages t1 and t2, while only after the operation it would be necessary to use a radiotherapy in the stages t3 and t4. the possibility of a preoperative irradi ... | 1975 | 806145 |
| motility of bacillus subtilis during growth and sporulation. | the change of motility and the presence of flagella were followed throughout growth and sporulation in a standard sporulating strain and in 19 cacogenic sporulation mutants of bacillus subtilis. for the standard strain, the fraction of motile cells decreased during the developmental period to less than 10% at t4. motility was lost well before the cells lose their flagella. conditions reducing the decrease of motility also reduced sporulation: motile cells never contained spores. the decrease of ... | 1975 | 806579 |
| studies on human thyroxine-binding globulin (tbg). ix. some physical, chemical, and biological properties of radioiodinated tbg and partially desialylated tbg. | thyroxine-binding globulin (tbg) and partially desialylated or slow tbg (stbg) were purified from human serum by affinity chromatography. purified tbg was identical to tbg present in serum by the criteria of electrophoretic mobility, affinity for thyroxine (t4), and heat-inactivation response. purified stbg had slower electrophoretic mobility and lower affinity for t4. both bound t4 in an equimolar ratio, were immunoprecipitable, and had similar inactivation t1/2 at 61 degrees c. tbg and stbg we ... | 1975 | 806610 |
| radiation dose distributions and their optimization. | the current situation in the radiotherapy treatment of carcinoma of the larynx is discussed from a physicist's point of view and in the light of the results of one series of patients. the results suggest that the spatial distribution of dose obtainable with supervoltage irradiation for treatment of t1, to t4 no mo cases is not far from the ideal, and that it is not difficult to prescribe an optimal distribution. a significant difference in the rate of local cure was found between those treated ... | 1975 | 806760 |
| effect of thyrotropin-releasing hormone (trh) on plasma glucocorticoids and thyroxine in cattle. | the repeated systemic infusion of trh (200 mug, twice daily) was effective in repeatedly elevating plasma t4 levels (20-40 min postinfusion) for the 3 experimental days. the post-trh treatment (saline infusion) exhibited a depression of plasma thyroxine levels, possibly explained by previous high thyroxine levels exerting a suppressive effect on the hypothalamic-pituitary-thyroid axis. a depression of plasma glucocorticoid levels was shown within 1 hr in both experiments after trh administration ... | 1975 | 806923 |
| construction and characterization of a chimeric plasmid composed of dna pfrom escherichia coli and drosophila melanogaster. | a chimeric plasmid has been constructed in vitro from colicin e1 factor (col e1), nontransmissible r-factor rsf-1010, and drosophila melanogaster dnas by the sequential action of escherichia coli endonuclease ri(eco ri) and t4 phage dna ligase. the chimeric plasmid was assembled in two stages--first, a composite plasmid consisting of col e1 and rsf 1010 was constructed, followed by partial digestion of the composite with eco ri (in order to open one of the susceptible cleavage sites) and ligatio ... | 1975 | 807234 |
| discrepancy between the measurement of thyroxine-binding prealbumin plasma level and binding capacity in protein-calorie malnutrition. | the measurement of thyroxine-bindung prealbumin (tbpa) in protein-calorie malnutrition by two different techniques leads to the recognition of an unexpected discrepancy. whereas tbpa plasma levels as measured by immunodiffusion are markedly decreased to 29.3% of the normal, those recorded by maximal binding capacity (tbpacap) are characterized by a wide dispersion. in the control group, the ratio between tbpacap and tbpa plasma level is 9.1. in the malnourished group on admission, the same ratio ... | 1975 | 807481 |
| [clinical studies on regulatory system of thyroid hormone secretion and serum triiodothyronine. part. i. solid-state radioimmunoassy for human serum tsh and its clinical application (author's transl)]. | a solid-state ria method using a plastic microtiter plate for human tsh was developed: 1) the choice of carrier protein for standard tsh was critical in this method and pooled sera from untreated graves patients was found to be suitable for this purpose. the mean lowest detectable tsh level was 0.2 muu/assay, which was almost equal to those reported by other methods. this method is superior in simple assay procedure, especially in the separation of bound and free tsh and in the shorter incubatio ... | 1975 | 807487 |
| [clinical studies on regulatory system of thyroid hormone secretion and serum triiodothyronine. part ii. development of rapid radioimmunoassay for triiodothyronine (author's transl)]. | a rapid and simple radioimmunoassay method for serum t3 was developed using home made potent rabbit anti-t3 serum: 1) the incubation mixture which contained 0.1 ml of 1:2,000 diluted anti-t3 serum (finally 1:20,000), 250 mug of 8-anilino-1-naphthalene sulphonic acid and 0.1 ml of serum was run at 37 degrees c for 1 hour. dextran-coated charcoal was added for separation of free and bound t3. no significant undersirable effects due to high incubation temperature and short incubation time was obser ... | 1975 | 807488 |
| subunit arrangement in the extended sheath of pyocin r. | an optical diffraction study has been made of electron micrographs of extended sheaths of pyocin r. it has been demonstrated that the extended sheath consists of annuli of six subunits, which are arranged in a helix of 3.57 annuli per one turn. the annulus repeat in the helix direction is 35a. the dimensions and probably the helical parameters of pyocin r sheath are different from those of t4 phage tail, but a structural correlation appears to exist between the extended sheath of pyocin r and th ... | 1975 | 807567 |
| high incidence of decreased serum triiodothyronine concentration in patients with nonthyroidal disease. | serum thyroxine (t4) and triiodothyronine (t3) concentration and binding were measured in 34 clinically euthyroid patients hospitalized for a wide variety of nonthyroidal diseases. despite clinical euthyroidism, serum t3 was in the hypothyroid range (less than 90 ng/100 ml) in 24 of the 34 patients, and the mean serum t3 of this group, 78.4 +/- 38.3 (sd), was significantly decreased from that of control, 134.0 +/- 29.3 ng/200 ml. mean serum t4 levels were essentially the same in both groups, 7.3 ... | 1975 | 807593 |
| patterns off recovery of the hypothalamic-pituitary-thyroid axis in patients taken of chronic thyroid therapy. | to determine the patterns of recovery of the hypothalamic-pituitary-thyroid axis following long-term thyroid hormone therapy, trh tests were performed on 8 euthyroid nongoitrous patients, 5 euthyroid goitrous patients, and 5 hypothyroid patients while they were taking full doses of thyroid hormone and 3, 7, 10, 14, 17, 21, 28, 35, 42, 49, and 56 days after stopping it. serum tsh, t3, and t4 were measured before and at multiple intervals over a 4-h period after giving 500 mug trh iv. in euthyroid ... | 1975 | 807596 |
| the thyroxine-binding properties of serum proteins. a competitive binding technique employing sephadex g-25. | a competitive binding technique is described for the estimation of the thyroxine (t4)-binding properties of serum proteins in dilute blood serum and lymph. when used in conjunction with an assay for total t4 the following parameters can be estimated: the number of functionally different t4 binding proteins, their individual association constants and binding capacities for t4, the amount of t4 which is bound to each binding species, and the concentration of unbound (free) t4. both human and sheep ... | 1975 | 807668 |
| subacute thyroiditis in a lateral thyroid gland: evaluation of the pituitary-thyroid axis during the acute destructive and the recovery phases. | subacute thyroiditis in a lateral, ectopic thyroid has been previously unreported. a 4 10/12-year-old girl had an enlarging mass in the left upper anterior neck. initially, the serum concentration of t4 was normal, t3 was elevated, and tsh was undetectable without response to trh. rai uptake was 1%. the data were consistent with subacute thyroiditis. twelve weeks later the serum concentration of t4 was low and tsh was elevated; thyroid replacement therapy was given for 20 weeks. when this was di ... | 1975 | 807695 |
| the one-step approach to thyroid function tests. the diagnostic thyroxine ratio (dtr)/serum thyroxine (t4) level combination. | a one-step approach to thyroid function tests is reported, using tetralute kits (ames). two parameters are obtained simultaneously--namely, the serum thyroxine (t4) level and the diagnostic thyroxine ratio (dtr), which correlates well with the free thyroxine index (fti) as determined by two separate tests-the t4 level and the triiodothyronine resin uptake ((t3u)) estimations. data presented from patients with a variety of thyroid states prove that the dtr, particularly in combination with the t4 ... | 1975 | 807790 |
| radioimmunoassay and the hormones of thyroid function. | radioimmunoassay (ria) has provided the tools for wide-reaching investigations that have changed and continue to change many important concepts of thyroid physiology and pathosphysiology. the ria vor human thyrotropin (tsh) was developed in 1965; development of the ria for triiodothyronine (t3), thyroxine (t4), thyroxine-binding globulin (tbg), and, recently, thyrothropin-releasing hormone (trh) and thyroglobulin (tg) followed. the capacity to measure nanogram and picogram concentrations with re ... | 1975 | 807972 |
| different effects of oral doses of triiodothyronine or thyroxine on the inhibition of thyrotrophin releasing hormone (trh) mediated thyrotrophin (tsh) response in man. | since contradicting results about the existence of t3 or t3 and t4 receptors in pituitary tissue have been reported, the influence of l-triiodothyronine (l-t3) or l-thyroxine (l-t4) on trh stimulated tsh release was investigated. oral administration of 50 mug l-t3 caused an increasing inhibition of tsh response to 400 mug trh from 64% 2 h after l-t3 intake to 29% after 24 h, while serum t3 peaks up to 5.45 ng/ml occurred between 2 to 4 h after l-t3 ingestion and became normal after 8 to 10 h. th ... | 1975 | 808065 |
| the effect of hypoglycemia on hypothalamic thyrotropin-releasing hormone (hrh) in the rat. | a rapid radioimmunoassay for trh with a high degree of specificity and sensitivity is described. the procedure is capable of measuring trh in amounts less than 15 pg/tube. such an assay system has enabled us to study the effect of hypoglycemia on hypothalamic trh content. forty-eight female, adult holtzman rats were divided into 8 groups of 6. regular insulin was injected intraperitoneally into each rat except for the basal group. a separate batch of similar rats was studied in the same fashion ... | 1975 | 808409 |
| [clinical studeis on the regulatory system of thyroid hormone secretion and serum triiodothyronine. part iii. studies on thyroid hormone change and its relationship when tsh in cases with subclinical hypothyroidism (hashimoto's thyroiditis and 131i treated graves' disease)]. | changes in thyroid hormone levels and their relationship with tsh in cases with hashimoto's thyroiditis and 131i treated graves' disease in subclinical hypothyroid state were investigated: 1) in 34 cases with hashimoto's thyroiditis, tsh levels was 14.7 +/- 26.8 muu/ml (mean +/- s.d.), t3 144.5 +/- 33.6 rg/100 ml; t4 6.7 +/- 2.4 mug/100 ml; t3ru 25.4 +/- 3.2%; f.t.i. 2.0g +/- o.89; t3/t4 2.46+/- 1.04%. it was noted that tsh levels revealed significant positive correlation with t3/t4 (r=0.77); si ... | 1975 | 808432 |
| [studies on hypophyseo-thyroid function in patients with chronic thyroiditis (author's transl)]. | it is well known that serum tsh levels are elevated in most patients with chronic thyroiditis, even if the patient exhibits normal thyroid function tests. the determination of serum tsh levels in these patients is thought to be the most sensitive indicator of subclinical hypothyroidism. in this study, the hypophyseo-thyroid functions of untreated euthyroid patients with chronic thyroiditis were evaluated. serum t3 levels in most of these patients were raised or at high normal levels, although se ... | 1975 | 808434 |
| serum thyroxine and thyroxine-binding proteins in chronic renal failure without nephrosis. | total serum thyroxine (t4), free thyroxine index (fti), thyroxine binding globulin (tbg) binding capacity, serum albumin, alpha-globulins and urinary protein excretion were measured in 50 patients with chronic renal failure, but without nephrotic syndrome. 25 patients were undergoing chronic hemodialysis. t4 was within the normal range in most patients. there was a tendency to lower t4 values as compared to an age and sex-matched control group, but this did not reach statistical significance. tb ... | 1975 | 808556 |
| failure of propranolol to alter thyroid iodine release, thyroxine turnover, or the tsh and prl responses to thyrotropin-releasing hormone in patients with thyrotoxicosis. | a dual isotope method allowing simultaneous analysis of both endogenous thyroidal release and peripheral thyroxine disposal was employed in four patients with thyrotoxicosis before and during propranolol therapy (160 mg/day) to determine whether beta adrenergic blockade with this agent affected the secretion or metabolism of thyroid hormone. since catecholamines may be involved in the regulation of both thyrotropin (tsh) and prolactin (prl) release from the pituitary, the effect of propranolol o ... | 1975 | 808558 |
| clinical evaluation of new indicators of free thyroxine concentration and thyroxine-binding globulin capacity. | a rapid and simple method is described for the indirect measurement of free thyroxine (t4) concentration and maximal thyroxine-binding globulin (tbg) capacity applying a single kit of thyopac-4. initially, a value for total t4 is determined, after which the patient's serum is added to permit estimation of t4 corrected for abnormal tbg concentration. the ratio of increased radioactivity in the supernatant after the addition of patient's serum to that obtained using pooled normal serum is designat ... | 1975 | 809219 |
| the late effects of neonatal hyperthyroidism upon the feedback regulation of tsh secretion in rats. | rats made thyrotoxic with large doses of thyroxine (t4) during the neonatal period (neo-t4) show many abnormalities as adults. these usually include impaired body, pituitary and thyroid growth, diminished pituitary and serum tsh concentrations, a diminished serum t4 and a diminished response to ptu challenge and to thyrotropin-releasing hormone (trh) stimulation. experiments are presented which show that these rats are hypersensitive to feedback regulation by t4 in a manner similar to that seen ... | 1975 | 809256 |
| estimation of the maximal t4-binding capacity of tbg using the triosorb test in serum treated with dextran-coated charcoal. | a new method for the estimation of the maximal t4-binding capacity of tbg (max. tbg) in serum (dextran-coated charcoal-triosorb method) was devised. thyroxine (t4) concentration in test sera were determined by the tetrasorb method and then t3 resin sponge uptake (t3 rsu) was determined after extraction of 70% of the endogenous t4 with dextran-coated charcoal. the binding capacity of unsaturated tbg in treated sera was estimated from the reciprocal of t3 rsu. max. tbg was calculated from the ari ... | 1975 | 809258 |
| ribonucleoside diphosphate reductase induced by bacteriophage t4. iii. isolation and characterization of proteins b1 and b2. | ribonucleoside diphosphate reductase determined by bacteriophage t4 consists of a tight complex (alpha2beta2) of the polypeptide chains alpha (mr = 80,000 to 85,000) and beta (mr = 35,000). the alpha2 dimer (= protein b1) was purified from escherichia coli b infected with t4 mutant nrdb55 (yeh, y.c., and tessman, i. (1972) virology 47, 767-772) which carries an amber mutation in the gene coding for the beta polypeptide chain. protein b1 contained binding sites for datp, an allosteric effector of ... | 1975 | 809436 |
| detection of human anti-thyroxine and anti-triiodothyronine antibodies in different thyroid conditions. | anti-thyroxine (t4) and anti-triiodothyronine (t3) antibodies have been demonstrated in man. it was assumed that antibodies were at least partially saturated in vivo by the hormones. the initial step of the method therefore consisted in a dissociation of the postulated antigen-antibody complex by a 45% ammonium sulfate precipitation. the second part of the method consisted in incubating the euglobulins with trace amounts of 125i-t3 and 131i-t4. the hormones bound to the gammaglobulins were then ... | 1975 | 809458 |
| thyroxine in human amniotic fluid. | total and free t3 and t4 concentrations were measured in human amniotic fluid and in fetal and maternal blood. before 20 weeks, the mean af-t4 level was 0.24 mug/dl; there is a progressive increase in concentration with gestational age. at term, the mean af total t4 level was much less (0.64 mug/dl) than in fetal or maternal serum (9.3 and 11.3 mug/dl, respectively). most of the t4 (99.4%) in af is protein bound, presumably to tbg as in serum, but the mean ft4 concentration in af at term (4.13 n ... | 1975 | 809559 |
| [therapy and prevention using t3/t4 hormone. 5 years of clinical and practical experience with novothyral]. | 1975 | 809635 | |
| effects of acute and chronic administration of trh on tsh and prolactin secretion in normal and hypothyroid rats. | intravenous injection of the synthetic tripeptide (pyroglu-his-pro-nh2:trh) effected the prompt release of tsh and prolactin (prl) from the pituitary of the goitrous rat. plasma tsh and prl levels increased 2-3-fold within 1 min after the injection of 0.4 and 2 mug trh. intravenous injection of 20 mug of l-thyroxine (t4) induced repletion of tsh to supranormal levels in the adenohypophysis of goitrous rats without a significant change in prl stores. the acute administration of trh (2 and 50 mug) ... | 1975 | 809721 |
| [peripheral conversion of t4 and t3 in man]. | our investigations of the peripheral metabolism of t4 and t3 in man demonstrate clearly that t3 is secreted by the thyroid gland and is peripherally formed by conversion from t4. the calculation of the disposal rates indicate furthermore that 40% of the daily metabolised t4 is converted to t3. in this way more than 60% of the daily production of t3 results from peripheral conversion of t4. our results support the hypothesis that the physiological action of the thyroid hormones is effected mainly ... | 1975 | 809755 |
| [principals of hormone substitution in thyrectomized patients with carcinoma of the thyroid gland (author's transl)]. | the substitution of thyrectomized patients with carcinoma of the thyroid with l-thyroxin has advantages compared to a substitution with triiodothyronine, 200 mug t4/d are sufficient to obtain a negative trh test in most patients. for security it is suggested to performe a general substitution of these patients with 300 mug t4/d. this dose is very well tolerated. to high doses of substitution cause a "damage" of the thyreotrop in a part of the patients. this is demonstrated by a transient thyreot ... | 1975 | 809804 |
| prognostic value of thyrotropin-releasing hormone stimulation test in endogenous depression. | thyrotropin-releasing hormone (trh) stimulation tests were performed in 19 patients with endogenous depression before treatment and when they had apparently recovered following antidepressive treatment. an increase in the maximal serum thyrotropin (tsh) response to trh of more than 2.0 muu/ml was found in all of ten patients who did not relapse, while such an increase was found in only one of nine patients who did relapse within 6 months. i. e., a correct prognosis was possible in 94.7% (95% con ... | 1975 | 809999 |
| protirelin stimulation test and thyroid function during treatment of depression. | thyroid levels were estimated in 15 patients with endogenous depressions. before electroconvulsive treatment (ect), serum thyroxine (t4) and free t4 index values were elevated (p less than .02). after recovery from depression, the levels were normal. serum triiodothyronine (t3) and free t3 index were normal both before and after ect. serum thyrotropin (tsh) levels were also normal and not substantially altered by the ect procedure. the mean maximal tsh response to protirelin (thyrotropin-releasi ... | 1975 | 810113 |
| comparison of serum free thyroxine indices and "corrected" thyroxine tests. | a dual competitive protein-binding assay for serum thyroxine (t4) is described. the assay is called the "corrected" t4 index and can be performed simultaneously with the determination of total t4. this method correlated significantly with the free t4 index and the effective t4 ratio. the "corrected" t4 index was compared for precision and diagnostic accuracy with the effective t4 ratio and two different free t4 indices. improved modifications of the thyroxine and triiodothyronine sephadex uptake ... | 1975 | 810277 |
| effect of hypothalamic deafferentation on the secretion of thyrotropin in resting conditions in the rat. | complete hypothalamic deafferentation in normal male rats, either limited to the median eminence, arcuate nucleus, and basal parts of ventromedial nuclei, or including, in addition, the ventromedial nuclei, dorsomedial hypothalamus, and a large part of the posterior hypothalamus, caused a decrease of resting serum tsh levels and a marked lowering of the pituitary tsh concentration. partial frontal anterior cuts caused similar changes, whereas partial posterolateral cuts, or a complete deafferent ... | 1975 | 810344 |
| development of the hypothalamic-pituitary-thyroid axis in the neonatal rat. | the hypothalmic content of thyrotropin-releasing hormone (trh), the pituitary concentration of thyroid-stimulating hormone (tsh), and the serum concentrations of tsh, thyroxine (t4), and triiodothyronine (t3) have been determined at different intervals during the first 50 days following birth in the rat. from a minimum concentration of 1 pg/mug protein at birth, the hypothalamic concentration of trh increased to a maximum of 5 to 6 pg between 16 and 28 days of age. serum and pituitary tsh concen ... | 1975 | 810345 |
| thyrotropin releasing hormone (trh): dopa potentiation and biogenic amine studies. | the present study in mice demonstrated the trh when administered over 5 days remained active in the everett dopamine potentiation test. no evidence of tolerance was observed. in fact, an accumulative effect of trh appeared to take place. ablation of the adrenals, ovaries, testes, pineal, spleen, parathyroid, one kidney, or thymus did disrupt this behavioral potentiation of dopamine by trh. trh was found to potentiate the effects of imipramine. t3, t4, and tsh were found to be active in the dopa ... | 1975 | 810812 |
| thyroid hormones in the elderly sick: "t4 euthyroidism". | thyroid function and serum levels of triiodothyronine (t3) and thyroxine (t4) were investigated in 79 euthyroid geriatric patients. of the 59 inpatients and 20 outpatients 35 (59%) and 2, respectively, had low t3 levels. in contrast, 7 (12%) and 6 (30%), respectively, had raised t4 levels. two further patients were excluded from the study because of raised levels of thyroid-stimulating hormone. thyroxine-binding globulin was greatly increased in both groups of patients, but low serum albumin lev ... | 1975 | 811313 |
| gonococcal growth factors in tissue cultures. | growth of neisseria gonorrhoeae in the presence of rhesus monkey kidney (re2) cells containing eagle's minimal essential medium (mem) 'conditioned' by 18-20 h of contact with re2 cells began 3-4 h after inoculation and by 16-20 h had reached a maximum. when 'conditioned' medium (cm) was removed from the tissue cells and replaced with fresh medium a 5-6 h lag period occurred before multiplication of gonococci began and by 16 h growth was also near a maximum. cm removed from tissue cells supported ... | 1975 | 811344 |
| heterologous deoxyribonucleic acid uptake and complexing with cellular constituents in competent bacillus subtilis. | with competent cultures of bacillus subtilis the uptake of escherichia coli deoxyribonucleic acid (dna) is about 50% that for homologous dna. uptake of phage t6 dna, if any, is of the order of 7%, while nonglucosylated phage t6 (t6) dna is taken up almost as effectively as homologous dna. both t6 and t4 dna interfere only minimally with uptake of homologous dna; by contrast, t6 dna competes with homologous dna as effectively as the latter itself. these results indicate that the glucose residues ... | 1975 | 811646 |
| pathogenesis and immunology of experimental gonococcal infection: role of iron in virulence. | addition of iron componds to inocula of the relatively avirulent t3 or t4 colony types of gonococci increased their lethality for chicken embryos after intravenous inoculation but had little or no effect on the highly virulent t1 or t2 types. the toxicity of nonviable inocula, killed cells or sonicates, was not significantly affected by ecogenous iron. addition of the iron-binding protein conalbumin reduced or delayed the lethal effect of t1, but not t3, gonococci although growth of both colony ... | 1975 | 812826 |
| [response of thyrotropin (tsh) to the stimulation with hypothalamic releasing factor (trf) in hypothyroid children]. | the normal human serum thyrotropin (tsh) measured by radioimmunoassay in 36 children was 3.3 +/- 1.13 muui/ml. no differences dependent on age or sex were found. stimulation by intravenous injection of 100 mug of trf has been carried out in 7 euthyroid children and in 14 with hypothyroidism. tsh was determined prior to, and during trf stimulation. among other thyroid tests included in this study were: serum t3 uptake, total thyroxine, serum protein-bound iodine, 131ina uptake and thyroid scannin ... | 1975 | 813748 |
| [phage t4 partial diploidy obtained with the method of dna interrupted injection. i. analysis of the genetic structure and phage progeny reproduction process]. | phage t4 chromosome fragmentation is shown to take place when dna injection is interrupted, a fragment length being strictly controlled by the interval from the moment of adsorbtion till the moment of an interruption. populations of the bacteria cells infected by the phage t4 partial diploids are produced with the method of dna interrupted injection. in the population a merodiploid involves some phage t4 amber mutant and a phage "wild" type chromosome fragment of the size controlled. to construc ... | 1975 | 768746 |
| [preparation of functioning recombinant (hybrid) dna molecules in vitro (genetic engineering experiments)]. | in this paper we describe the preparation of hybrid plasmid consisting of cole1 dna and dna of r6k plasmid. cole1 plasmid represents a circular dna with the molecular weight of 4,2-10(6) daltons. it determines colicine synthesis e1, has relaxed control of replication and is present in the cell in several dozens copies. transmissive plasmid b6k represents a circular dna molecule with the molecular weight of 28-10(6) daltons. it confers the resistance to amplicillin and streptomycin and belongs to ... | 1975 | 776738 |
| hypothyroidism. | we found biochemical evidence of hypothyroidism (low t3 and t4 and elevated tsh) in azotemic patients. hemodialysis did not correct the hypothyroidism but renal transplantation did. the hypothyroidism is probably a consequence of impaired thyroidal elaboration of thyroid hormone, as well as decreased peripheral conversion of t4 to t3. the impaired thyroidal gland function may be secondary to the increased concentration of aryl acids found in chronic renal disease. | 1975 | 785453 |
| genetic control of bacteriophage t4 baseplate morphogenesis. i. sequential assembly of the major precursor, in vivo and in vitro. | 1975 | 765481 | |
| genetic control of bacteriophage t4 baseplate morphogenesis. ii. mutants unable to form the central part of the baseplate. | 1975 | 765482 | |
| genetic control of bacteriophage t4 baseplate morphogenesis. iii. formation of the central plug and overall assembly pathway. | 1975 | 765483 | |
| transversion mutagenesis in bacteriophage t4. | transversion mutations can be distinguished from transition mutations by the use of special tauii mutants of bacteriophage t4. methyl methanesulfonate did not induce reversion of the tester mutants along transversion or transition pathways from a:t1 base pair sites, nor along transversion pathways from g:c base pair sites. ethyl methanesulfonate and n-methyl-n-nitrosourea, however, induced both transversions and transitions at an a:t base pair site; no transversions were detected at g:c-sites. m ... | 1975 | 765723 |
| [phage t4 partial diploids obtained with the method of dna interrupted injection. ii. the mapping technique based on the physical size measurement of the diploid region]. | populations of the e. coli b mixedly infected with the whole chromosome of the amber mutant in respect to two genes under consideration and with a chromosome fragment of the phage t4 "wild" type are examined. the fragment length with which both of the amber mutants defect functions are compensated is determined to measure physical distance between the genes. distances so obtained do not depend on recombination frequencies and are shown to be additive and "complementary". the latter property mean ... | 1975 | 765775 |
| [replication of the dna of t4 phage]. | 1975 | 766447 | |
| receptors for t2, t4 and t6 phages in sh. dysenteriae 7 and other serotypes of sh. dysenteriae. | the sensitivity of four strains of sh. dysenteriae and of nine strains representing other serotypes of sh. dynsenteriae to phages t2, t4 and t6 was examined. different extracts, prepared from sensitive strains were tested for their capacity of phage inactivation. we found that the receptor substance for phage t2 is localized differently in various strains: in sh. dysenteriae 7, it was found in bacterial extracts obtained by water/phenol at 68 degrees c and in extracts obtained by trichloracetic ... | 1975 | 766504 |
| [cyclic rearrangements in the incomplete genome of t4d phage transferred into a cell during a injections of dna]. | the genome structure of phage t4 chromosome fragments obtained by the method of dna interrupted injection is studied directly. anfragment population is shown by homogeneous in sizes. the fragment sizes are proved to the indentical to sizes. the fragment sizes are proved to be identical to sizes expected from the method conditions. the individual fragment genomes are shown to be cyclic gene permutations uniformly distributed on the map of physical distances between genes. the results suggest that ... | 1975 | 773754 |
| [a genetic and physiologic study of mutations of t4 phage suppressing the lysis defect of gene stii mutants]. | a new gene rvi phage t4b is found. mutations rvi belong to the class of r-mutations of t4b. mutations rvi do not show the lysis inhibition after superinfection and determine the r-morphology of plaques on escherichia coli cr63 lawn. mutations rvi are gene-specific suppressors of stii lysis defect, but do not suppress the e lysis defect. alleles rvi and rvi+ are co-dominated with regard to the ability to suppress the stii lysis defect. the suggest the stoichiometric character of rvi gene function ... | 1975 | 773757 |
| [effect of restricting the action of an amber-mutation suppressor contained in bacteriophage t4 genome]. | the action of a bacteriophage suppressor can be restricted due to mutations arising in the genome of the host bacteria. bacterial strains escherichia coli bn and can were isolated in which a complete restriction of the action of phage suppressor psu+ took place. in thees strains obtained the restriction of serin-specific phage suppressors psu + a and psu + b is brought about. the action of bacteriophage suppressor su3+ containing in e. coli can is not abolished in this strain. the abolish of the ... | 1975 | 767202 |
| [reversion induction in phage t4 mutants in escherichia coli strains with defective rna polymerase]. | the reversion induction in mutants of phage t4 under the effect of base analogues in rna-polymerase escherichia coli mutants is studied. in double mutant e. coli rif-r stl-r strain phage t4 mutates several times more frequently than in the parental strain of e. coli rfs-522, containing an intact enzyme. | 1975 | 767205 |
| [induced and spontaneous mutagenesis in phage t4 in escherichia coli strains with mutant rna polymerase]. | study was made of the frequency of induced and spontaneous mutations in phage t4 in rna polymerase escherichia coli strains. it has been shown that the rate of induced mutagenesis by base analogues increases in two ruv-mutants of phage t4 carrying mutations of the transition type, unlike the frameshift mutant which does not revert under these conditions. an increase in the level of spontaneous mutations in the phage is also found when rna polymerase mutations are introduced into the system. the ... | 1975 | 767206 |
| physico-chemical and biological study of excision-repair of uv--irradiated phix174 rf dna in vitro. | we have studied excision-repair of uv-irradiated phix174 rfi dna in vitro with uv-specific endonuclease from micrococcus luteus (uv-endo), dna polymerase i from escherichia coli and dna ligase from phage t4 infected e. coli. excision-repair was measured a) by physico-chemical methods, i.e. by determination of the conversion of rf i dna into rf ii dna by uv-endo and by the subsequent conversion of rf ii dna ligase, b) by biological methods i. e. by measuring the ability of the reaction product to ... | 1975 | 1052535 |
| genetic evidence for an additional function of phage t4 gene 32 protein: interaction with ligase. | gene 32 of bacteriophage t4 is essential for dna replication, recombination, and repair. in an attempt to clarify the role of the corresponding gene product, we have looked for mutations that specifically inactivate one but not all of its functions and for compensating suppressor mutations in other genes. here we describe a gene 32 ts mutant that does not produce progeny, but in contrast to an am mutant investigated by others, is capable of some primary and secondary dna replication and of formi ... | 1975 | 1055398 |
| thylakoid membrane polypeptides of chlamydomonas reinhardtii: wild-type and mutant strains deficient in photosystem ii reaction center. | unstacked thylakoid membrane vesicles were obtained from a homogenate of chlamydomonas reinhardtii by flotation in a 1.8 m sucrose layer containing 5 mm hepes (n-2-hydroxyethylpiperazine-n-2-ethanesulfonic acid)-10 mm edta (ph 7.5). sodium dodecyl sulfate-gradient gel electrophoresis showed that the wildtype membranes have a total of at least 33 polypeptides ranging in molecular weights from 68,000 to less than 10,000. the wild-type and three non-photosynthetic mutant strains were studied with r ... | 1975 | 1056023 |
| mutants of t7 bacteriophage inhibited by lambda prophage. | mutants in gene 20, a new t7 gene, cannot grow on rex+ lambda lysogens. gene 20-- mutants suppress in double mutants the phenotype of t7 ligase negative mutations, but not vice versa. amber 20- mutants have been obtained. there are differences between these t7 mutations and the similar t4 rii mutations. there are host mutations which permit t7 20- mutants to grow on lambda+ lysogens. t7 dna synthesis on normal lambda+ lysogens infected with 20- mutants is essentially normal, but the dna is not p ... | 1975 | 1059155 |
| characterization of dna condensates induced by poly(ethylene oxide) and polylysine. | high-molecular-weight dna is known to collapse into very compact particles in a salt solution containing polymers like poly(ethylene oxide) [(eo)n] or polyacrylate. the biological relevance of this phenomenon is suggested by our recent finding that high concentrations of the highly acidic internal peptides found in the mature t4 bacteriophage head, as well as poly(glutamic acid) and poly(aspartic acid), can collapse dna in a similar manner. the structure of dnas collapsed by various methods has ... | 1975 | 1060108 |
| use of gene 32 protein staining of single-strand polynucleotides for gene mapping by electron microscopy: application to the phi80d3ilvsu+7 system. | a method for visualizing rna-dna duplex regions along a single strand of dna in the electron microscope is described. a preparation of rna molecules is hybridized to a long dna strand containing the coding sequences (genes) for some of the rnas. t4 gene 32 protein, which binds selectively and cooperatively only to the single-strand regions, is added, followed by glutaraldehyde. the resulting nucleic acid-gene 32 complex is adsorbed to the surface of an electron microscope grid in the presence of ... | 1975 | 1060131 |
| reconstruction of bacteriophage t4 dna replication apparatus from purified components: rolling circle replication following de novo chain initiation on a single-stranded circular dna template. | the protein products of t4 bacteriophage genes 41, 43, 45, 44, and 62 have been purified to near homogeneity using an assay which measures their stimulation of dna synthesis in a crude lysate of escherichia coli cells in fected by an appropriate mutant phage. when all of these proteins and t4 gene 32 protein are incubated in the presence of deoxyribonucleoside and ribonucleoside triphosphates, extensive dna synthesis occurs on both single and double-stranded dna templates. analysis of this in vi ... | 1975 | 1061070 |
| t4 thyrotoxicosis with normal or low serum t3 concentration. | eight patients are described with elevated plasma thyroxine (t4) concentrations, but normal or low plasma triiodothyronine (t3) concentrations by radioimmunoassay. all were suffering also from non-thyroidal illness, which in six cases was severe, and in two fatal. the two patients in reasonable general health were acromegalic. it is possible that in sick thyrotoxic patients there is an impairment of peripheral conversion of t4 to t3, similar to that occurring in sick euthyroid patients. however, ... | 1975 | 1061545 |
| delayed response of ankle jerk time changes in decreasing thyroid function in comparison with the serum cholesterol changes. | 1. serum cholesterol, pbi and ankle jerk time (ajt) were measured simultaneously in a group of not yet treated patients, where a relatively steady state of thyroid function was expected, and in a treated group, where change to lower thyroid function was supposed (thyrostatic drugs, near total thyroidectomy, radioablation of thyroid). 2. serum cholesterol correlated poorly with pbi (r = --0,4427), better correlation was achieved after logarithmic transformation of pbi values (r = --0,6839). 3. re ... | 1975 | 58781 |
| [experiences in the determination of thyroxine iodine in serum in various functional conditions of the thyroid gland]. | a report is given on the method of the thyroxine iodine determination in the serum. of 213 patients the result of the thyroxine iodine determination was compared with the clinically and radiologically established functional condition of the thyroid gland. the findings are discussed. similar results were also reported of other in-vitro-tests (t3-test, t4-test, bej and pbj). according to our experiences we consider the thyroxine iodine determination in the serum siutable as screening test which - ... | 1975 | 56823 |
| [immunogenic properties of dna from e. coli and t4 phage, containing 5-bromouracil]. | 5-budr incorporated into e. coli or t4 phage dnas is an immunogenic determinant. immunodominance of 5-budr is determined by the chemical structure of dna molecule into which it is incorporated. in e. coli dna, 5-budr inhibits immunogenic activity of all other bases. one can conclude that in this dna 5-budr is the dominant antigenic determinant. in t4 dna, 5-budr acts as an additional antigenic determinant. anti-5-budr-t4-dna contains antibodies to 5-budr and glucosylated 5-hmc. | 1975 | 55955 |
| effect of ionic strength and ionic composition of assay buffers on the interaction of thyroxine with plasma proteins. | when plasma proteins are diluted with buffer the ionic strength and ionic composition of that buffer affects the interactions between thyroxine (t4) and its plasma protein-binding sites. increases in phosphate, chloride or barbiturate ion concentration from 50 to 200 mmol/l caused a significant decrease in the affinity of plasma proteins for t4, and a concurrent increase in the concentration of unbound t4. these results cannot be completely accounted for by changes in ionic strength since at the ... | 1975 | 447 |
| bacteriophage t4 baseplate components. ii. binding and location of bacteriophage-induced dihydrofolate reductase. | the location of t4d phage-induced dihydrofolate reductase (dfr) has been determined in intact and incomplete phage particles. it has been found that phage mutants inducing a temperature-sensitive dfr (dfrts) procude heat-labile phage particles. the structural dfr produced by these ts mutants was shown to assume different configurations depending on the temperature at which the phage is assembled. morphogenesis of incomplete phage particles lacking the gene 11 protein on their baseplates was foun ... | 1975 | 516 |
| sialic acid in thyroglobulin. ii. influence of sialic acid on ionization of tyrosine residues. | during electrophoresis in polyacrylamide gel at ph 9-5, it was noticed that sialic acid-poor thyroglobulin contains fewer low molecular weight fragments than sialic acid-rich thyroglobulin. splitting off of sialic acid diminishes thenumber of phenolic groups of tyrosine, mit, dit and t4, which dissociate below ph 12-5. this phenomenon was interpreted as a result of lowered hydrophilia of these regions of the thyroglobulin molecule which contains tyrosine and its iodinated derivatives. | 1975 | 3147 |
| gel filtration and related studies on the reconstitution of bacteriophage t4. | 1975 | 3469 | |
| carrier-determined tolerance in vitro. | a primary immune response to normal bdf1 spleen cells was obtained in vitro to the t-independent antigen tnp-t4 coliphage. this anti-tnp response was suppressed by exposing the spleen cells for 6 hr to tnp bound either to isologous or heterologous gamma-globulin. the suppression was hapten specific. in contrast, tnp-albumin conjugates did not induce tolerance in vitro. | 1975 | 46237 |
| letter: does t4 toxicosis exist? | 1975 | 46567 | |
| stimulation with thyrotrophin-releasing hormone (trh) during antithyroid treatment. | during antithyroid treatment a total of 88 trh tests was performed in 56 clinical euthyroid patients. 56% had negative response to trh (i.e. delta tsh smaller than 2 muu/ml) after being treated in average 12.6 months and no relation between the duration of treatment and the outcome of the trh test was found. in the group with positive trh tests (i.e. delta tsh greater than 2 muu/ml) the mean t4 value was slightly decreased (5.8 plus or minus sd 2.5 mug/100 ml) while the mean t3 value was normal ... | 1975 | 47216 |
| letter: does t4-toxicosis exist. | 1975 | 47524 | |
| the thyroid in ulcreative colitis and crohn's disease. iii. the daily fractional turnover of thyroxine. | the daily fractional turnover of thyroxine (t4) labelled with 131 i has been determined in 11 patients with ulcerative colitis (uc) of crohn's disease and 8 controls. the daily fractional turnover of 131i-t4 was significantly increased in the patient group. the daily total disposal of t4 iodine was not significantly different although it was excessive in 3 of the 11 patients. the amount of t4 in plasma did not differ significantly between the patients and the controls. it is concluded that the t ... | 1975 | 47700 |
| letter: does t4 toxicosis exist? | 1975 | 48107 | |
| hormonal pattern of relapse in hyperthyroidism. | 22 patients with grave's disease were followed up for up to a year after antithyroid drug therapy was discontinued. clinical assessment and serum t3, t4, and thyroid-stimulating-hormone (t.s.h.) estimations were done serially and simultaneously. serum t3 or t4 concentrations may be elevated briefly in the first few weeks after antithyroid drugs are stopped, as a rebound effect not necessarily indicative of subsequent relapsf. clinical relapse of hyperthyroidism with subsequent improvement on ant ... | 1975 | 48121 |
| [diagnosis and control of therapy of thyroid disorders by trh-test (author's transl)]. | tsh-measurement before and after stimulation with trh proved to be of good value in the diagnosis of thyroid dysfunctions, better than other parameters including j-131-test. during treatment of hypothyroid disorder trh-test, often repeatable, allows estimation of t4 substitution dosis. in graves disease therapy, furthermore, should be judged by in-vitro or clinical parameters. | 1975 | 48181 |
| effect of butyldiiodohydroxybenzoate on pituitary-thyroid interplay. | the effect of bhdb, an analogue of thyroxine, on the pituitary-thyroid system was studied in the rat. bhdb produced low plasma t4 and t3 concentrations similar to those produced by methimazole, but failed to elevate plasma tsh and to produce goiter because of displacement of t4 from the binding protein. low plasma thyroid hormone concentrations were due to an increase of fecal loss of thyroid hormones. by releasing excess iodide, bhdb blocked the development of goiter produced by methimazole. | 1975 | 48263 |
| serum triiodothyronine 7-15 years after fractionated low dose radioiodine therapy of thyrotoxicosis. | in 189 of 334 patients, who had been treated with fractionated doses of radioiodine for graves' disease 7-15 years ago, the serum concentrations of triiodothyronine have been estimated in additition to the following parameters: protein bound 127-iodine (pb-127-i), free thyroxine index, cholesterol- and tsh-level in serum, tendon reflex time and clinical index according to billewitz et al. (1969). in forty-one of the 189 sera the free t4 (aft4) and free t3 (aft3) concentrations were measured as w ... | 1975 | 48437 |
| letter: does t4-toxicosis exist? | 1975 | 48915 | |
| rapid effects of single small doses of l-thyroxine and triiodo-l-thyronine on growth hormone, as studied in the rat by radioimmunoassy. | the effects of thyroid hormone deprivation and restitution on growth hormone (gh) economy have been studied in the rat by means of a specific radioimmunoassay. the pituitary gh content and the plasma gh levels before and during stimulation with pentobarbital ("pb-test") were studied in male rats at different intervals after surgical thyroidectomy (t), and in t rats at different time intervals after the ip injection of 0.20, 1.75, and 5.0 mug thyroxine (t4) or 0.05, 0.10, 0.20 and 1.0 mug triiodo ... | 1975 | 49266 |
| preparation of 125-i-labeled human thyroxine-binding alpha globulin and its turnover in normal and hypothyroid subjects. | a protein with the electrophoretic, immunologic, and hormone-binding properties of thyroxine-binding globulin (tbg) has been prepared from human plasma and labeled with radioiodine (125-i) by an enzymatic method of iodination. the [125-i]tbg retained the electrophoretic and immunologic characteristics of unlabeled tbg but exhibited a partial loss of thyroxine-binding activity, as assessed by affinity chromatography. the in vivo behavior of [125i]tbg was studied in six euthyroid subjects (control ... | 1975 | 49363 |
| is "t4 toxicosis" a normal biochemical finding in elderly women? | the lack of equivalence in the distrubtion of normal ranges for free thyroxine index (ft4i) and free triiodothyronine index (ft3i) in the over sixty-five age-group, as compared with the fifteen-sixty-five age-group, supports the idea that "t4 toxicosis" is a common biochemical finding in elderly women. the disparity between ft4i and ft3i ranges was also reflected in the true free t4 and free t3 levels which were measured in some cases. these results suggest that when an increased ft4i is found i ... | 1975 | 49741 |
| third hl-a segregant series: genetic analysis and molecular independence on lymphocyte surface. | five sera which detect two alleles of the third hl-a locus (t2 and t4) are described. statistical analysis of a panel of 220 donors gave gene frequencies in a french parisian population which are comparable to the results of scandinavian authors. segregation observed in 50 families emphasized the linkage disequilibrium with sd2 alleles. t1 was found to be associated with one part of w22 (da30) and t3 with the other part non-da30). no recombination was observed between sd2 and sd3, and the dista ... | 1975 | 50634 |
| [relation of trh test to thyroidal suppression test by triiodothyronine in patients with hyperthyroidism under treatment with antithyroid drugs (author's transl)]. | the relation of the trh test to the t3 suppression test was investigated in 43 patients with hyperthyroidism receiving antithyroid drugs for 6 to 27 months (average 14 months). trh tests were performed by measuring serum tsh levels before and 15, 30, 45, 60, 90 and 120 minutes after intravenous injection of 500 mug of synthetic trh. serum tsh was measured by a double antibody radioimmunoassay. two weeks later, the t3 suppression test was performed by measuring the 24-hr thyroidal uptake of radio ... | 1975 | 50954 |
| acute changes in thyroid function in patients treated with radioactive iodine. | serum triiodothyronine (t3) and thyroxine (t4) were measured in thirteen unselected hyperthyroid patients before and at frequent intervals after iodine-131 treatment. there was an abrupt rise in t3 from a pretreatment mean of 250 ng/100 ml to a maximum of 365 ng/100 ml at 24 hours. total t4 rose from a mean of 18.7 mug/100 ml to a maximum of 22.3 mug/100 ml at 24-48 hours. these findings may explain why an occasional patient develops acute thyroid crisis after radioiodine treatment. | 1975 | 52005 |
| letter: t4 toxicosis. | 1975 | 52028 |