Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| relationship of halitosis with gastric helicobacter pylori infection. | gastric infection with helicobacter pylori may be one of the main causes of halitosis. this study was performed to evaluate the relationship of helicobacter pylori infection with halitosis. | 2015 | 26622273 |
| fast eating speed increases the risk of endoscopic erosive gastritis in korean adults. | fast eating or overeating can induce gastrointestinal diseases such as gastritis. however, the association between gastritis and speed of eating is unclear. the aim of this study was to determine whether eating speed is associated with increased risk of endoscopic erosive gastritis (eeg). | 2015 | 26634096 |
| helicobacter pylori eradication: gastric cancer prevention. | the principal effect of helicobacter pylori infection is lifelong chronic gastritis, affecting up to 20% of younger adults but 50% to 80% of adults born in resource-rich countries before 1950. | 2015 | 26633126 |
| [in vitro antibacterial activity of chilean propolis against helicobacter pylori]. | propolis is a natural product derived from beekeeping. it has anesthetic, anti-inflammatory, immune-stimulant and antibacterial properties on grampositive and gramnegative bacteria. however, little is known regarding its activity on helicobacter pylori. this bacteria colonizes about half of the world's population and is associated with chronic gastritis, peptic ulcer and gastric cancer. | 2015 | 26633110 |
| a randomized controlled study comparing reverse hybrid therapy and standard triple therapy for helicobacter pylori infection. | reverse hybrid therapy is an 1-step 2-phase treatment for helicobacter pylori (h. pylori) infection with less cost than standard triple therapy. we conducted a randomized, controlled study to compare the efficacies of standard triple therapy and reverse hybrid therapy in the treatment of h. pylori infection. from october 2012 to march 2015, consecutive h. pylori-infected subjects were randomly allocated to receive either a reverse hybrid therapy (pantoprazole plus amoxicillin for 12 days and cla ... | 2015 | 26632893 |
| multiple genetic analysis system-based antibiotic susceptibility testing in helicobacter pylori and high eradication rate with phenotypic resistance-guided quadruple therapy. | antibiotics resistance in helicobacter pylori (h. pylori) is the major factor for eradication failure. molecular tests including fluorescence in situ hybridization, pcr-restriction fragment length polymorphism, and dual priming oligonucleotide-pcr (dpo-pcr) play critical roles in the detection of antibiotic susceptibility; however, limited knowledge is known about application of multiple genetic analysis system (mgas) in the area of h. pylori identification and antibiotics resistance detection.t ... | 2015 | 26632710 |
| primary antibiotic resistance to helicobacter pylori strains isolated from children in northern iran: a single center study. | initial resistance to antibiotics is the main reason for the failure of helicobacter pylori (h. pylori) eradication in children. | 2015 | 26635938 |
| eradication of helicobacter pylori in children by triple therapy regimens of amoxicillin, omeprazole, and clarithromycin or azithromycin. | the present study aimed to evaluate the effect of classical and azithromycin-containing triple therapy eradication regimen against h. pylori in children, and to determine the level of patients' tolerance. | 2015 | 26635936 |
| the prevalence of gastric intestinal metaplasia and distribution of helicobacter pylori infection, atrophy, dysplasia, and cancer in its subtypes. | objectives. gastric intestinal metaplasia (im) is frequently encountered and is considered a precursor of gastric adenocarcinoma. in the van region of turkey, gastric adenocarcinoma incidence is high but the prevalence of gastric im is not known. helicobacter pylori (h. pylori) infection is a main factor leading to atrophy, im, and cancer development in the stomach. the aim of the current study was to investigate the prevalence of im and its subtypes and the prevalence of h. pylori infection, at ... | 2015 | 26635875 |
| comparison of 10-day sequential therapy with 7-day standard triple therapy for helicobacter pylori eradication in inactive peptic ulcer disease and the efficiency of sequential therapy in inactive peptic ulcer disease and non-ulcer dyspepsia. | eradication rates of standard triple therapy for helicobacter pylori infections have decreased in recent years due to a worldwide increase in bacterial resistance. sequential therapy has the advantage of a two-phase treatment regimen and achieves a superior result for h. pylori eradication in peptic ulcer disease. however, no study has yet compared the efficacy of sequential therapy for h. pylori eradication exclusively in inactive duodenal ulcer (idu) or non-ulcer dyspepsia (nud). | 2015 | 26635102 |
| chemoprevention trials of gi cancers in asia. | cancers are among the leading causes of morbidity and mortality worldwide, with gastrointestinal (gi) luminal cancers accounting for a large proportion of cancer incidence. chemoprevention of gi luminal cancers is important to reduce this cancer burden. screening for and eradication of helicobacter pylori (h. pylori) in areas with high gastric cancer incidence is a safe and effective strategy to decrease the incidence of gastric cancer. eradication of h. pylori also seems to be effective in prev ... | 2015 | 26651257 |
| screening of gastric cancer in asia. | in north-eastern asian countries, where incidence and mortality of gastric cancer remain very high, population-based gastric cancer screenings have been conducted under governmental subsidy in japan and korea. reduction of gastric cancer mortality by the screening was documented in japan, but the japanese gastric cancer screening with the x-ray photofluorography is criticized for its high cost and a low uptake rate. although the korean program seems to achieve a high-rate of uptake with increasi ... | 2015 | 26651251 |
| organoids as model for infectious diseases: culture of human and murine stomach organoids and microinjection of helicobacter pylori. | recently infection biologists have employed stem cell derived cultures to answer the need for new and better models to study host-pathogen interactions. three cellular sources have been used: embryonic stem cells (esc), induced pluripotent stem cells (ipsc) or adult stem cells. here, culture of mouse and human gastric organoids derived from adult stem cells is described and used for infection with the gastric pathogen helicobacter pylori. human gastric glands are isolated from resection material ... | 2015 | 26650279 |
| role of helicobacter pylori in gastric cancer: advances and controversies. | gastric cancer is one of the most common cancers of digestive system globally and helicobacter pylori (hp) infection is believed to be a major risk factor. hp can be classified into different types based on the presence and expression level of caga and vaca, and, when exposed to adverse environment, hp changes its phenotype from helical type to coccoid type, with each having different pathogenicity. the mechanisms of hp-induced gastric carcinogenesis and progression are complicated, including dn ... | 2015 | 26645900 |
| effect of native gastric mucus on in vivo hybridization therapies directed at helicobacter pylori. | helicobacter pylori infects more than 50% of the worldwide population. it is mostly found deep in the gastric mucus lining of the stomach, being a major cause of peptic ulcers and gastric adenocarcinoma. to face the increasing resistance of h. pylori to antibiotics, antimicrobial nucleic acid mimics are a promising alternative. in particular, locked nucleic acids (lna)/2'-omethyl rna (2'ome) have shown to specifically target h. pylori, as evidenced by in situ hybridization. the success of in viv ... | 2015 | 26645765 |
| [helicobacter pylori-mediated carcinogenesis and tyrosine phosphatases]. | 2015 | 26638623 | |
| the participation of p53 and bcl-2 proteins in gastric carcinomas associated with helicobacterpylori and/or epstein-barr virus (ebv). | in the presented studies p53 and bcl-2 proteins expression were evaluated in samples of gastric carcinomas in patients with helicobacter pylori or ebv or without h. pylori/ebv infection. the studies were conducted on 64 adult patients with gastric adenocarcinomas: 16 patients with h. pylori (caga+)-positivity (group 1), 14 with ebv-positive tumours (group 2), 12 with h. pylori/ebv-positive tumours (group 3) and 22 patients with h. pylori/ebv-negative tumours (group 4). h. pylori presence in gast ... | 2015 | 26638529 |
| predictors of gastric neoplasia in cases negative for helicobacter pylori antibody and with normal pepsinogen. | individuals negative for helicbacter pylori antibody and with a normal pepsinogen test (group a) are regarded as being at low risk in serum gastric cancer screening known as the abc method, and endoscopy is not recommended; however, this group may include 2-10% of gastric cancer cases. | 2015 | 26637894 |
| potential effect of chronic helicobacter pylori infection on glucose metabolism of mongolian gerbils. | to assess the effect of helicobacter pylori (h. pylori) infection on metabolic parameters in mongolian gerbils. | 2015 | 26640335 |
| helicobacter pylori infection associated with type 2 diabetic nephropathy in patients with dyspeptic symptoms. | the aim of this conventional case-control study was to investigate the prevalence and relationship between helicobacter pylori infection in type 2 diabetes mellitus (dm) and diabetic nephropathy (dn). | 2015 | 26547504 |
| t-regulatory cells as part of strategy of immune evasion by pathogens. | under physiological conditions, regulatory processes can suppress the immune response after elimination of a pathogen and restore homeostasis through the destruction and suppression of obsolete effector cells of the immune system. the main players in this process are t-regulatory cells (tregs) and immature dendritic cells, which suppress the immune response by their own products and/or by inducing synthesis of immunosuppressive interleukins il-10, il-35, and transforming growth factor (tgf-β) by ... | 2015 | 26547064 |
| correction: defining the roles of ifn-γ and il-17a in inflammation and protection against helicobacter pylori infection. | 2015 | 26544971 | |
| no association between helicobacter pylori infection and diabetes mellitus among a general japanese population: a cross-sectional study. | several case-control studies have reported that patients with diabetes mellitus (dm) had a higher prevalence of helicobacter pylori infection than those without dm, but these findings remain equivocal. additionally, there are few studies examining associations between east asian caga-positive h. pylori and dm. this cross-sectional study aimed to investigate whether h. pylori infection was a possible risk factor for dm in a general japanese population. the study included 5165 subjects (1467 men, ... | 2015 | 26543737 |
| helicobacter pylori vaca toxin causes cell death by inducing accumulation of cytoplasmic connexin 43. | 2015 | 26561781 | |
| helicobacter pylori among patients with symptoms of gastroduodenal ulcer disease in rural uganda. | to meet key millennium development goals, the rural population needs to be reached for health assessment and service delivery. gastroduodenal ulcer disease is a common ailment affecting the health of people in uganda. a cross-sectional study was conducted at bwera hospital in kasese district of western uganda, to establish the prevalence and predisposing factors of helicobacter pylori among gastroduodenal ulcer disease patients. | 2015 | 26560860 |
| trends in helicobacter pylori eradication rates by first-line triple therapy and related factors in eradication therapy. | trends in successful eradication of helicobacter pylori using first-line triple therapy, consisting of a proton pump inhibitor, amoxicillin, and clarithromycin, have been understudied. we evaluated h. pylori eradication rates at a single center over the last 10 years and identified risk factors related to eradication failure. | 2015 | 26552455 |
| time to learn from the past and prepare for the future in helicobacter pylori eradication. | 2015 | 26552453 | |
| impact of creatinine clearance on helicobacter pylori eradication rate in patients with peptic ulcer disease. | gastrointestinal complaints are common in patients with kidney failure. the aim of this study was to investigate the effect of creatinine clearance on helicobacter pylori (hp) eradication rate in patients with peptic ulcer disease. | 2015 | 26552348 |
| evaluation of antimicrobial resistance of helicobacter pylori in the last 15 years in west poland. | increasing resistance to drugs represents a serious problem in treatment of infections with helicobacter pylori, providing cause of frequent therapeutic failures. present study aimed at analysis of changes in resistance of h. pylori to antibiotics in west poland within the recent 15 years. 108 strains of h. pylori were analysed, isolated from gastric mucosa of adult patients. group 1 involved 66 strains isolated in years of 1998/1999. group 2 comprised 42 isolates obtained in years of 2013/2014. ... | 2015 | 26551571 |
| a case of menetrier's disease without helicobacter pylori or hypoalbuminemia. | menetrier's disease is a rare premalignant hypertrophic gastropathy. it is characterized by huge gastric mucosal folds, peripheral edema due to protein loss and upper git symptoms such as epigastric pain, discomfort, nausea and vomiting. | 2015 | 26551554 |
| the diagnosis value of promoter methylation of uchl1 in the serum for progression of gastric cancer. | aberrant promoter methylation has been considered as a potential molecular marker for gastric cancer (gc). however, the role of methylation of flnc, thbs1, and uchl1 in the development and progression of gc has not been explored. | 2015 | 26550574 |
| polymorphisms at locus 4p14 of toll-like receptors tlr-1 and tlr-10 confer susceptibility to gastric carcinoma in helicobacter pylori infection. | helicobacter pylori (h. pylori) -induced gastric inflammation impacts the functions of leptin- and ghrelin-producing cells in the gastroduodenum. inflammation resulting from h. pylori sensing via toll-like receptors (tlrs) and the associated downstream signaling largely remain ambiguous. here, we investigated the role of gut hormones, pro-inflammatory cytokines and single nucleotide polymorphisms (snps) associated with tlr 4p14 in h. pylori disease in 30 subjects with non-ulcer dyspepsia (nud), ... | 2015 | 26559190 |
| typical and atypical symptoms of gastro esophageal reflux disease: does helicobacter pylori infection matter? | to analyze whether the presence of helicobacter pylori (h. pylori) infection could affect the quality of symptoms in gastro-esophageal reflux disease (gerd) patients. | 2015 | 26558157 |
| antibiotic treatment for helicobacter pylori: is the end coming? | infection with the gram-negative pathogen helicobacter pylori (h. pylori) has been associated with gastro-duodenal disease and the importance of h. pylori eradication is underscored by its designation as a group i carcinogen. the standard triple therapy consists of a proton pump inhibitor, amoxicillin and clarithromycin, although many other regimens are used, including quadruple, sequential and concomitant therapy regimens supplemented with metronidazole, clarithromycin and levofloxacin. despite ... | 2015 | 26558152 |
| diagnosis and therapy of non-variceal upper gastrointestinal bleeding. | non-variceal upper gastrointestinal bleeding (ugib) is defined as bleeding proximal to the ligament of treitz in the absence of oesophageal, gastric or duodenal varices. the clinical presentation varies according to the intensity of bleeding from occult bleeding to melena or haematemesis and haemorrhagic shock. causes of ugib are peptic ulcers, mallory-weiss lesions, erosive gastritis, reflux oesophagitis, dieulafoy lesions or angiodysplasia. after admission to the hospital a structured approach ... | 2015 | 26558151 |
| helicobacter pylori: effect of coexisting diseases and update on treatment regimens. | the presence of concomitant diseases is an independent predictive factor for non-helicobacter pylori (h. pylori) peptic ulcers. patients contracting concomitant diseases have an increased risk of developing ulcer disease through pathogenic mechanisms distinct from those of h. pylori infections. factors other than h. pylori seem critical in peptic ulcer recurrence in end stage renal disease (esrd) and cirrhotic patients. however, early h. pylori eradication is associated with a reduced risk of re ... | 2015 | 26558147 |
| comparing the efficacy of four different protocols for eradicating of helicobacter pylori infection in ahvaz, southwest iran. | helicobacter pylori (h. pylori) is the common cause of many gastrointestinal diseases, especially peptic ulcer. therefore, a successful treatment of this infection decreases the financial burden on health systems. | 2015 | 26557940 |
| helicobacter pylori caga suppresses apoptosis through activation of akt in a nontransformed epithelial cell model of glandular acini formation. | h. pylori infection is the most important environmental risk to develop gastric cancer, mainly through its virulence factor caga. in vitro models of caga function have demonstrated a phosphoprotein activity targeting multiple cellular signaling pathways, while caga transgenic mice develop carcinomas of the gastrointestinal tract, supporting oncogenic functions. however, it is still not completely clear how caga alters cellular processes associated with carcinogenic events. in this study, we eval ... | 2015 | 26557697 |
| role of helicobacter pylori infection in gastric carcinogenesis: current knowledge and future directions. | helicobacter pylori (h. pylori) plays a role in the pathogenesis of gastric cancer. the outcome of the infection depends on environmental factors and bacterial and host characteristics. gastric carcinogenesis is a multistep process that is reversible in the early phase of mucosal damage, but the exact point of no return has not been identified. therefore, two main therapeutic strategies could reduce gastric cancer incidence: (1) eradication of the already present infection; and (2) immunization ... | 2015 | 26556993 |
| autoimmune gastritis: pathologist's viewpoint. | western countries are seeing a constant decline in the incidence of helicobacter pylori-associated gastritis, coupled with a rising epidemiological and clinical impact of autoimmune gastritis. this latter gastropathy is due to autoimmune aggression targeting parietal cells through a complex interaction of auto-antibodies against the parietal cell proton pump and intrinsic factor, and sensitized t cells. given the specific target of this aggression, autoimmune gastritis is typically restricted to ... | 2015 | 26576102 |
| [programs for continuing medical education: a session; 1. prevention of gastric cancer based on an understanding of the natural history of helicobacter pylori-associated gastritis]. | 2015 | 26571729 | |
| gastroprotective effects and antimicrobial activity of lithraea molleoides and isolated compounds against helicobacter pylori. | lithraea molleoides (vell.) engl. (anacardiaceae) is a medicinal plant traditionally used in south america to treat various ailments, including diseases of the digestive system. | 2015 | 26571088 |
| correlation between tympanosclerosis and helicobacter pylori. | tympanosclerosis is a condition caused by calcification of tissues in the middle ear mucosa that sometimes results hearing loss. helicobacter pylori is one of the pathological and etiologic factors in the development of tympanosclerosis. | 2015 | 26568799 |
| helicobacter pylori-negative differentiated adenocarcinoma of the stomach. | a 58-year-old japanese man was diagnosed with differentiated adenocarcinoma of the stomach. histological findings of the resected specimen revealed well- to moderately-differentiated tubular adenocarcinoma (tub1, tub2), 13 mm in diameter, which invaded into the submucosa (sm1, 300 μm) and lymphovascular lumen (ly1). serum antibody against helicobacter pylori (hp) and the (13)c-urea breath test were negative, and there were no atrophic changes in the tumor-adjacent mucosa. the immunohistochemical ... | 2015 | 26567998 |
| helicobacter pylori eradication prevents metachronous gastric neoplasms after endoscopic resection of gastric dysplasia. | there is insufficient data about the role of eradication of h. pylori after endoscopic resection (er) for gastric dysplasia. the aim was to investigate the benefit of h. pylori eradication after er in patients with gastric dysplasia to prevent metachronous gastric neoplasms. | 2015 | 26580072 |
| transforming growth factor-β: an important mediator in helicobacter pylori-associated pathogenesis. | helicobacter pylori (h.pylori) is a gram-negative, microaerophilic, helical bacillus that specifically colonizes the gastric mucosa. the interaction of virulence factors, host genetic factors, and environmental factors contributes to the pathogenesis of h. pylori-associated conditions, such as atrophic gastritis and intestinal metaplasia. infection with h. pylori has recently been recognized as the strongest risk factor for gastric cancer. as a pleiotropic cytokine, transforming growth factor (t ... | 2015 | 26583078 |
| does emerging clarithromycin resistance signal an obituary to empirical standard triple therapy for helicobacter pylori infection? | despite 30 years of its discovery, the ideal therapeutic regimen against helicobacter pylori is still evasive. clarithromycin-based standard triple therapy which has been considered the first line empirical therapy has been failing in many parts of the world, due to rising resistance against clarithromycin, forcing the use of alternate regimens. in this context, we studied the local antibiotic resistance patterns against h. pylori and its impact on standard triple therapy in our region. all pati ... | 2015 | 26541342 |
| choosing and using non-steroidal anti-inflammatory drugs in haemophilia. | the management of pain and inflammation in haemophilic arthropathy is challenging due to the lack of anti-inflammatory analgesic agents perfectly suitable for this population. non-steroidal anti-inflammatory drugs (nsaids) are widely used in the management of arthritis due to their analgesic and anti-inflammatory effects. their use in persons with haemophilia (pwh), however, is limited due to increased risk of bleeding mainly from the upper gastrointestinal (ugi) tract. cyclooxygenase-2 (cox-2) ... | 2015 | 26538453 |
| expression of macrophage migration-inhibitory factor in duodenal ulcer and its relation to helicobacter pylori infection. | the aim of this study was to examine the expression of macrophage migration-inhibitory factor (mif) in duodenal ulcer epithelial cells and its relation to helicobacter pylori (hp) infection, and to discuss the pathogenic roles of mif expression and hp infection in duodenal ulcer. mif protein and mrna expression was examined in samples from patients with duodenal ulcer with and without hp infection (n = 40 each, experimental group), and in normal duodenal bulb mucosal tissue (n = 40, control grou ... | 2015 | 26535701 |
| occult h. pylori infection partially explains 'false-positive' results of (13)c-urea breath test. | in a previous study, ubit-100 mg, (otsuka, spain), a commercial (13)c-urea breath test omitting citric acid pre-treatment, had a high rate of false-positive results; however, it is possible that ubit detected low-density 'occult' infection missed by other routine reference tests. we aimed to validate previous results in a new cohort and to rule out the possibility that false-positive ubit were due to an 'occult' infection missed by reference tests. | 2015 | 26535122 |
| a combined antral and corpus rapid urease testing protocol can increase diagnostic accuracy despite a low prevalence of helicobacter pylori infection in patients undergoing routine gastroscopy. | the effects of an increased risk of sampling error and the lower prevalence of helicobacter pylori infection on the diagnostic accuracy of standard invasive tests needs to be considered. despite evidence of enhanced yield with additional biopsies, combined rapid urease tests (ruts) have not been widely adopted. we aimed to compare the diagnostic efficacy of a combined antral and corpus rapid urease test (rut) to a single antral rut in a low prevalence cohort. | 2015 | 26535121 |
| the correlation of helicobacter pylori with the development of cholelithiasis and cholecystitis: the results of a prospective clinical study in saudi arabia. | gallstone disease is a common surgical ailment. helicobacter pylori has a role in upper gastrointestinal disorders, including gallstones. this study aimed to determine the association of h. pylori with gallstones, so developing a preventative strategy for gallstone formations. | 2015 | 26531273 |
| [diagnosis and treatment of helicobacter pylori infection in pediatrics: recommendation for 2014 clinical practice]. | helicobacter pylori (h. pylori) infection is a large worldwide infection usually acquired during childhood, whose prevalence in pediatric population varies, with lower incidence rates in developed countries compared to developing countries (up to 10-15% and 70%, respectively). diagnosis can be performed both with endoscopic-based methods and noninvasive diagnostic tests, such as urea breath test and fecal antigen. current guidelines recommend endoscopic evaluation of the young patients, in order ... | 2015 | 26530493 |
| association of cagpai integrity with severeness of helicobacter pylori infection in patients with gastritis. | the helicobacter pylori cag pathogenicity island (cagpai) is involved in delivery of caga effector protein and peptidoglycan into host cells and also in il-8 induction in the human gastric tissue. diversity of cagpai may affect disease status and clinical outcome of the infected patients. our study was aimed to investigate diversity of this island and its intactness in iranian patients to investigate possible associations between cagpai integrity and pathological changes of the infected tissue. | 2015 | 26530303 |
| [a study to determine the optimum antigens for the serodiagnosis of helicobacter pylori infection in japanese patients and the association with igg subclass and gastric cancer]. | atrophic gastritis is caused by helicobacter pylori infection, and is involved in gastric cancer. in this study, we investigated the association with total igg and igg subclass antibodies using several strains isolated from japanese in h. pylori positive and negative individuals, and gastric atrophy using measuring pepsinogen i and ii levels. we found that total igg antibody measurement using typical japanese genotype as an antigen was available for diagnosis of h. pylori infection, whereas igg1 ... | 2015 | 26529968 |
| [upper g.i. cancer. iii. gastric cancer prevention of gastric cancer by eradication of helicobacter pylori]. | 2015 | 26529802 | |
| effect of helicobacter pylori eradication in iranian patients with functional dyspepsia: a prospective, randomized, placebo-controlled trial. | whether patients with functional dyspepsia (fd) should receive helicobacter pylori (h. pylori) eradication therapy remains controversial. the objective of this trial was to evaluate the effect of h. pylori eradication therapy on dyspeptic symptoms of patients with fd. | 2015 | 26528337 |
| preparation and evaluation of amoxicillin loaded dual molecularly imprinted nanoparticles for anti-helicobacter pylori therapy. | this paper reports studies on preparation and evaluation of amoxicillin loaded dual molecularly imprinted nanoparticles (amo/dual-mips) designed for anti-h. pylori therapy. both mnqa and amona were chosen as templates to prepare dual-mips using inverse microemulsion polymerization method. nqa was modified with myristic acid (mnqa) to become amphiphilic and assist in leaving nqa cavities on the surface of dual-mips for h. pylori adhesion. amona was applied to produce imprinting sites in dual-mips ... | 2015 | 26524712 |
| effectiveness of second- through sixth-line salvage helicobacter pylori treatment: bismuth quadruple therapy is almost always a reasonable choice. | 2015 | 26523455 | |
| diagnosis of helicobacter pylori infection: current options and developments. | accurate diagnosis of helicobacter pylori (h. pylori) infection is a crucial part in the effective management of many gastroduodenal diseases. several invasive and non-invasive diagnostic tests are available for the detection of h. pylori and each test has its usefulness and limitations in different clinical situations. although none can be considered as a single gold standard in clinical practice, several techniques have been developed to give the more reliable results. invasive tests are perfo ... | 2015 | 26523098 |
| outcome evaluation of clarithromycin, metronidazole and lansoprazole regimens in helicobacter pylori positive or negative children with resistant otitis media with effusion. | to compare the efficacy of two treatment regimens among helicobacter pylori stool antigen positive children suffering from resistant otitis media with effusion. | 2015 | 26521817 |
| [helicobacter pylori-associated diseases]. | this article summarizes the main conclusions of the studies presented at digestive disease week this year (2015) related to helicobacter pylori infection. despite the undeniable widespread reduction in the prevalence of h. pylori infection, developing countries continue to have substantial infection rates. the prevalence of clarithromycin, metronidazole and quinolone resistance is markedly higher in most countries and continues to rise. although h. pylori eradication reduces the incidence of gas ... | 2015 | 26520195 |
| potassium-competitive acid blockers (p-cabs): are they finally ready for prime time in acid-related disease? | the need for new acid suppressing agents with improved pharmacology and superior antisecretory effects to address unmet clinical needs in acid-related disorders has been evident for over a decade. recent new antisecretory drugs (ir-omeprazole and mr-dexlansoprazole) only provide a small incremental advance in control of acid secretion over the delayed-release proton pump inhibitors. vonoprazan (a new potassium-competitive acid blocker) displays more potent and extended 24 h acid suppression and ... | 2015 | 26513137 |
| the application of high-resolution mass spectrometry-based data-mining tools in tandem to metabolite profiling of a triple drug combination in humans. | patients are usually exposed to multiple drugs, and metabolite profiling of each drug in complex biological matrices is a big challenge. this study presented a new application of an improved high resolution mass spectrometry (hrms)-based data-mining tools in tandem to fast and comprehensive metabolite identification of combination drugs in human. the model drug combination was metronidazole-pantoprazole-clarithromycin (met-pan-clar), which is widely used in clinic to treat ulcers caused by helic ... | 2015 | 26515003 |
| genetic polymorphism of mdm2 snp309 in patients with helicobacter pylori-associated gastritis. | helicobacter pylori plays an important role in gastric cancer, which has a relatively low inciduence in thailand. mdm2 is a major negative regulator of p53, the key tumor suppressor involved in tumorigenesis of the majority of human cancers. whether its expression might explain the relative lack of gastric cancer in thailand was assessed here. | 2015 | 26514489 |
| relationship of interleukin-1b gene promoter region polymorphism with helicobacter pylori infection and gastritis. | helicobacter pylori infection is associated with gastritis, peptic ulcer disease and gastric carcinoma. the severity of damage is determined by the interplay between environmental/behavioral factors, bacterial pathogenicity genes and host genetic polymorphisms that can influence the secretion levels of inflammatory cytokines. accordingly, this study aimed to identify polymorphisms in the il-1b and il-1rn genes and their associations with h. pylori infection, caga gene of h. pylori, and gastroduo ... | 2015 | 26517486 |
| the prevalence of helicobacter pylori infection in patients with gastric and duodenal ulcers - a 10-year, single-centre experience. | helicobacter pylori (h. pylori) occurs throughout the world and causes gastroduodenal diseases. there is data indicating a change in the prevalence of h. pylori infection worldwide. the prevalence of h. pylori is 80% in turkey, while it is higher in many developing countries, and the rate of infection varies throughout the world. in many developing countries, the prevalence of infection exceeds 90% by adulthood. | 2015 | 26516382 |
| limitations of urease test in diagnosis of pediatric helicobacter pylori infection. | the diagnosis of helicobacter pylori (h. pylori) infection is usually based on the results of urease test and histology. the urease test known as a simple and cheap method does not need special skills to perform or to read the result. the time needed for the test to turn positive depends on the concentration of bacteria, and the accuracy is up to the density of h. pylori density in the biopsy sample, which is generally lower in children than adolescents and adults. therefore, there are debates a ... | 2015 | 26566487 |
| expressional profiles of transcription factors in the progression of helicobacter pylori-associated gastric carcinoma based on protein/dna array analysis. | transcription factors (tfs) are crucial modulators of gene expression during the development and progression of gastric carcinoma. helicobacter pylori (h. pylori) is one of the most significant risk factors of gastric carcinoma, and it is widely known that chronic inflammation with h. pylori infection triggers gastric carcinogenesis through inflammation-carcinoma chain [gastric carcinogenesis stages: non-atrophic gastritis, chronic atrophic gastritis, intestinal metaplasia, dysplasia and gastric ... | 2015 | 26563475 |
| gastrointestinal bleeding in patients receiving oral anticoagulation: current treatment and pharmacological perspectives. | gastrointestinal bleeding (gib) is a potentially fatal and avoidable medical condition that poses a burden on global health care costs. the rate of major gib related to the use of some direct acting oral anticoagulant drugs (doacs), is higher than that detected in warfarin users. current strategies in the treatment of gibs in patients receiving warfarin or doacs (vitamin k, activated charcoal; hemodialysis; recombinant factor viia; [activated] prothrombin complex concentrates) including indicati ... | 2015 | 26508464 |
| dramatic increase in shp2 binding activity of helicobacter pylori western caga by epiya-c duplication: its implications in gastric carcinogenesis. | infection with caga-positive helicobacter pylori is critically associated with the development of gastric cancer. the caga-encoded caga is delivered into gastric epithelial cells via type iv secretion, where it interacts with and thereby deregulates the pro-oncogenic phosphatase shp2. east asian caga and western caga are two major caga species produced by h. pylori circulating in east asian countries and in the rest of the world, respectively. the shp2 binding site of western caga, termed the ep ... | 2015 | 26507409 |
| relationship between helicobacter pylori infection and metabolic syndrome. | to investigate the prevalence of metabolic syndrome (ms) and its components in patients with helicobacter pylori that was detected using histopathological diagnostic methods. | 2015 | 26510087 |
| rare disorders can be an underlying cause of cyclic vomiting: familial mediterranean fever, helicobacter pylori gastritis, and cavernous transformation of the portal vein. | considering the etiology of cyclic vomiting syndrome (cvs) in childhood, a variety of underlying organic causes has been clearly identified in the literature. the aim of this study was to emphasize that endoscopic evaluation in the first step may help diagnosis and treatment in patients with cvs, unlike the cvs-related "north american society for pediatric gastroenterology, hepatology and nutrition" (naspghan) consensus statement in 2008. | 2015 | 26510083 |
| influence of vitamin c and e supplementation on the eradication rates of triple and quadruple eradication regimens for helicobacter pylori infection. | in our study, we aimed to assess the effect of vitamin e and c supplementation to triple and quadruple helicobacter pylori eradication regimens. | 2015 | 26510082 |
| increased risk of chronic obstructive pulmonary disease among patients with helicobacter pylori infection: a population-based cohort study. | increasing evidence suggests that helicobacter pylori infection (hpi) may have extragastric manifestations, including the respiratory system. this study investigated the role of hpi in increasing the subsequent risk of chronic obstructive pulmonary disease (copd) in a nationwide population. | 2015 | 26364850 |
| mir-221 and mir-222 simultaneously target reck and regulate growth and invasion of gastric cancer cells. | although helicobacter pylori infection is necessary for development of gastric adenocarcinoma (gac), the underlying mechanism remains poorly defined. this study aimed to explore how mir-221 and mir-222 are dysregulated after h. pylori infection and how these 2 mirnas are involved in pathological development of gastric cancer. | 2015 | 26364844 |
| novel detection of helicobacter pylori in fish: a possible public health concern. | helicobacter pylori is one of the most common human pathogens worldwide with serious clinical outcomes. although, h. pylori is a major water-borne pathogen, its occurrence in fish is still unknown. this leads us to conduct the current study in order to clarify this point and to investigate the potential role of fish in the epidemiology of h. pylori. for this purpose, fecal samples were obtained from 315 fish from different species and were caught from various aquatic environments at different lo ... | 2015 | 26364719 |
| modeling the regulatory mechanisms by which nlrx1 modulates innate immune responses to helicobacter pylori infection. | helicobacter pylori colonizes half of the world's population as the dominant member of the gastric microbiota resulting in a lifelong chronic infection. host responses toward the bacterium can result in asymptomatic, pathogenic or even favorable health outcomes; however, mechanisms underlying the dual role of h. pylori as a commensal versus pathogenic organism are not well characterized. recent evidence suggests mononuclear phagocytes are largely involved in shaping dominant immunity during infe ... | 2015 | 26367386 |
| systematic review with meta-analysis: lactobacillus rhamnosus gg in the prevention of antibiotic-associated diarrhoea in children and adults. | the effects of probiotics are strain specific. the clinical effects of each strain need to be evaluated separately. | 2015 | 26365389 |
| evidence of gastric ulcer healing activity of maytenus robusta reissek: in vitro and in vivo studies. | maytenus robusta reissek (celastraceae) is traditionally used in brazilian folk medicine to treat gastric ulcer, as a substitute for m. ilicifolia, which is almost extinct. the gastroprotective properties of m. robusta were demonstrated previously using only preventive approaches, such as acute gastric ulcer models. however, the healing effect of m. robusta in gastric ulcers remains unclear. | 2015 | 26364940 |
| multiplex h. pylori serology and risk of gastric cardia and noncardia adenocarcinomas. | the reported associations with gastric adenocarcinoma and seropositivity to different helicobacter pylori antigens using multiplex serology have not been consistent across studies. we aimed to investigate the association between 15 different multiplex serology antigens and the risk of gastric cardia (gca) and gastric noncardia (gnca) adenocarcinomas in northeastern iran, a population with high rates of gastric adenocarcinoma. we included 272 cases of gastric adenocarcinoma (142 gca, 103 gnca, an ... | 2015 | 26383162 |
| significant association of interleukin4 intron 3 vntr polymorphism with susceptibility to gastric cancer in a south indian population from telangana. | gastric cancer (gc) is the fifth most common malignancy and remains a considerable public health burden worldwide. genetic variations in genes encoding cytokines and their receptors influence the intensity of the helicobacter pylori associated inflammatory response, which may contribute to individual differences in the outcome and severity of the disease. interleukin4 is a typical pleiotropic t helper 2 (th2) cytokine and is a critical mediator of th1/th2 balance. it is involved in the regulatio ... | 2015 | 26383107 |
| helicobacter pylori: a significant and treatable cause of chronic urticaria and angioedema. | two outpatient medical offices evaluated 204 patients with chronic urticaria during 2012. this article presents a retrospective study showing that 10% of patients with chronic urticaria may be infected with h. pylori. furthermore, eradication of infection can be followed by remission of urticaria, reduced morbidity from gastric ulcers, and cancer. | 2015 | 26383021 |
| exclusive moderate-dose radiotherapy in gastric marginal zone b-cell malt lymphoma: results of a prospective study with a long term follow-up. | in gastric malt lymphomas persisting after helicobacter pylori (h. pylori) eradication, a treatment by moderate-dose radiotherapy (rt) has been proposed but its efficacy has not been confirmed in large prospective series with long term endoscopic follow-up. | 2015 | 26395311 |
| declining trends in prevalence of helicobacter pylori infection by birth-year in a japanese population. | gastric cancer incidence and mortality have been decreasing in japan. these decreases are likely due to a decrease in prevalence of helicobacter pylori infection. our aim was to characterize the trends in prevalence of h. pylori infection focused on birth-year. we carried out a cross-sectional study that included 4285 subjects who were born from 1926 to 1989. we defined h. pylori infection by the serum h. pylori antibody titer. individuals having h. pylori infection and those with negative h. py ... | 2015 | 26395018 |
| association of salivary helicobacter pylori infection with oral diseases: a cross-sectional study in a chinese population. | the aim of this study was to detect the prevalence of oral h.pylori among adults and to investigate the correlation between h.pylori infection and common oral diseases. | 2015 | 26392812 |
| characterization of lesions in the stomach: will confocal laser endomicroscopy replace the pathologist? | confocal laser endomicroscopy (cle) permits microscopic visualization of the mucosa during endoscopy at an approximately 1000fold magnification, permitting endoscopists to obtain microscopic analysis during gastroscopy. this can result in optimized diagnosis of diffuse alterations such as gastric atrophy and intestinal metaplasia and may limit the sampling error of untargeted biopsies. it also allows risk stratification prior to endoscopic therapy of neoplastic lesions of the stomach. in these a ... | 2015 | 26381304 |
| association between pro-(il-8) and anti-inflammatory (il-10) cytokine variants and their serum levels and h. pylori-related gastric carcinogenesis in northern india. | interleukin (il)-8 -251 t/a and il-10 (-1082 g/a and -819/592 c/t) polymorphisms and their expression may influence gastritis, atrophy, intestinal metaplasia (im) and gastric cancer (gc) following h. pylori infection. | 2015 | 26380815 |
| noncoding genomics in gastric cancer and the gastric precancerous cascade: pathogenesis and biomarkers. | gastric cancer is the fifth most common cancer and the third leading cause of cancer-related death, whose patterns vary among geographical regions and ethnicities. it is a multifactorial disease, and its development depends on infection by helicobacter pylori (h. pylori) and epstein-barr virus (ebv), host genetic factors, and environmental factors. the heterogeneity of the disease has begun to be unraveled by a comprehensive mutational evaluation of primary tumors. the low-abundance of mutations ... | 2015 | 26379360 |
| impact of alcohol drinking on gastric cancer development according to helicobacter pylori infection status. | helicobacter pylori are major carcinogen of gastric cancer, but the associations among gastric cancer, h. pylori infection status, and alcohol consumption are not fully described. this study aimed to clarify how h. pylori infection status affects the association between alcohol consumption and gastric cancer risk. | 2015 | 26379079 |
| an infrared spectroscopy method to detect ammonia in gastric juice. | ammonia in gastric juice is considered a potential biomarker for helicobacter pylori infection and as a factor contributing to gastric mucosal injury. high ammonia concentrations are also found in patients with chronic renal failure, peptic ulcer disease, and chronic gastritis. rapid and specific methods for ammonia detection are urgently required by the medical community. here we present a method to detect ammonia directly in gastric juice based on fourier transform infrared spectroscopy. the a ... | 2015 | 26377936 |
| phosphorylation and inactivation of pten at residues ser380/thr382/383 induced by helicobacter pylori promotes gastric epithelial cell survival through pi3k/akt pathway. | phosphorylation of pten at residues ser380/thr382/383 leads to loss of phosphatase activity and tumor suppressor function. here, we found that phosphorylation of pten at residues ser380/thr382/383 was increased with gastric carcinogenesis, and more importantly, helicobacter pylori was a trigger of this modification in chronic non-atrophic gastritis. h. pylori could phosphorylate and inactivate pten in vivo and in vitro, resulting in survival of gastric epithelial cells. furthermore, stable expre ... | 2015 | 26376616 |
| helicobacter pylori neutrophil-activating protein induces release of histamine and interleukin-6 through g protein-mediated mapks and pi3k/akt pathways in hmc-1 cells. | helicobacter pylori neutrophil-activating protein (hp-nap) activates several innate leukocytes including neutrophils, monocytes, and mast cells. it has been reported that hp-nap induces degranulation and interleukin-6 (il-6) secretion of rat peritoneal mast cells. however, the molecular mechanism is not very clear. here, we show that hp-nap activates human mast cell line-1 (hmc-1) cells to secrete histamine and il-6. the secretion depends on pertussis toxin (ptx)-sensitive heterotrimeric g prote ... | 2015 | 26375619 |
| investigation of the association between glaucoma and helicobacter pylori infection using the 14c-urea breath test. | to investigate the association between glaucoma and helicobacter pylori infection by evaluating for the presence of h. pylori infection in patients with glaucoma using the 14c-urea breath test (14c-ubt). | 2015 | 26375337 |
| erratum for nell et al., dynamics of lewis b binding and sequence variation of the baba adhesin gene during chronic helicobacter pylori infection in humans. | 2015 | 26374120 | |
| gastric microbiota. | after the discovery of helicobacter pylori in 1983, the stomach was no longer considered a sterile environment. in 2015, evolving data shows that h. pylori is not the only inhabitant of the gastric mucosa. using culture-independent methods of analysis, a non-h. pylori microbial community has been recently observed in the human stomach, the so-called human gastric microbiota, along with h. pylori itself. increasing evidence supports the hypothesis that although h. pylori may be the most relevant, ... | 2015 | 26372828 |
| treatment of helicobacter pylori infection 2015. | many interesting articles have been published from many parts of the world over the last year assessing different issues around helicobacter pylori eradication therapy. this article will address the published literature over the last year pertaining to the topic of treatment of h. pylori infection. the main themes that emerge are assessing the efficacy of standard triple therapy, as well as exploring new first-line treatments, mainly optimized nonbismuth- and bismuth-containing quadruple therapi ... | 2015 | 26372826 |
| helicobacter pylori infection in pediatrics. | this review includes the main pediatric studies published from april 2014 to march 2015. the host response of treg cells with increases in foxp3 and tgf-β1 combined with a reduction in ifn-γ by teff cells may contribute to helicobacter pylori susceptibility in children. genotypic variability in h. pylori strains influences the clinical manifestation of the infection. helicobacter pylori infection is associated with variables indicative of a crowded environment and poor living conditions, while b ... | 2015 | 26372825 |
| extragastric diseases and helicobacter pylori. | the extragastric manifestations of helicobacter pylori infection still remain a very strong topic throughout the h. pylori world. indeed, h. pylori may interfere with many biological processes, both inside and outside of the stomach, possibly influencing or determining the occurrence of many diseases outside of the stomach. while its role in idiopathic thrombocytopenic purpura and sideropenic anemia has already been recognized, emerging evidence suggests that h. pylori may increase the risk of a ... | 2015 | 26372824 |
| helicobacter pylori and gastrointestinal malignancies. | helicobacter pylori infection is the principal trigger of gastric carcinogenesis and gastric cancer (gc) and remains the third leading cause of cancer-related death in both sexes worldwide. in a big japanese study, the risk of developing gc in patients with peptic ulcer disease who received h. pylori eradication therapy and annual endoscopic surveillance for a mean of 9.9 years was significantly lower after successful eradication therapy compared to the group with persistent infection (0.21%/yea ... | 2015 | 26372823 |