Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| comparison between serum thyroxine and triiodothyronine estimation and the trh test in the routine diagnosis of hyperthyroidism. | serum t3 and t4 levels have been determined by a radioimmunoassay technique and the trh test has been performed in 50 patients in whom hyperthyroidism could not be ruled out by the first clinical examination alone. each patient was then further evaluated in order to establish the state of the thyroid function. the extent to which the determination of t3 or t4 could replace the trh test in the routine diagnosis of hyperthyroisism was evaluated. the results showed that 26 of the 50 patients had no ... | 1977 | 403744 |
| divergent changes of serum 3,5,3'-triiodothyronine and 3,3',5'-triiodothyronine in patients with acute myocardial infarction. | the serum levels of thyroxine (t4), 3,5,3'-triiodothyronine (t3), 3,3',5'-triiodothyronine (reverse t3, rt3), thyroxine-binding globulin and thyroid-stimulating hormone have been monitored in 13 patients with acute myocardial infarction. the major changes recorded were a transient decrease in t3 and a transient increase in rt3. they reached a nadir and a peak, respectively, within three days. a conceivable explanation for these alterations is that the monodeiodination of t4 is diverted from the ... | 1977 | 403745 |
| the response of newborn sheep to trh with and without somatostatin. | hormone responses to a bolus injection of thyrotropin releasing hormone (trh) were studied in 8 newborn lambs between 6 and 19 hours of age. the effect of a bolus injection and 45 min infusion of somatostatin (srif) on these responses was studied in 2 other animals. serial measurements of serum tsh, prolactin, triiodothyronine (t3) and thyroxine (t4) were conducted for 2 to 6 h in all animals. mean baseline t4 and t3 concentrations were 12.6 microng/dl and 221 ng/dl, respectively, both significa ... | 1977 | 404129 |
| pituitary autonomy in hyperprolactinemic secondary amenorrhea: results of hypothalamic-pituitary testing. | twenty-seven women with secondary amenorrhea of greater than six months duration were subjected to multiple testing of hypothalamo-pituitary function. they were divided into normo-prolactinemic (group 1 mean serum prolactin (prl) 9.8 ng/ml; range 6.8 to 13.0 ng/ml; n=9) and hyperprolactinemic (group 2 mean 37.5 ng/ml; range 19.2 to 93.7 ng/ml; n=18) groups on the basis of 4 weekly baseline determinations. group 2 had significantly (p less than .05) lower serum lh and urinary pregnanediol levels ... | 1977 | 404308 |
| response to thyrotropin releasing hormone: an objective criterion for the adequacy of thyrotropin suppression therapy. | most serum thyrotropin (tsh) assays do not adequately discriminate between normal values and absent tsh. we therefore evaluated the tsh response to thyrotropin releasing hormone (trh) as a criterion for the adequacy of tsh suppression therapy. twenty-six outpatients with various thyroid disorders (cancer, 10; nodules, 9; miscellaneous, 4; hypothyroidism after 131i therapy for graves' disease, 3) were studied. using the frequent sampling technique (samples every 20 min) in two normal volunteers a ... | 1977 | 404309 |
| thyroid function at birth in infants of 30 to 45 weeks' gestation. | serum t4 was measured in cord blood of 2,683 infants of gestational ages 30 to 45 weeks and birth weights of 1,460 to 5,250 gm. in addition, serum tbg was measured in 180, and serum tsh in 125 of these infants. mean serum t4 increased with gestational age from 9.4 microng/dl at 30 weeks to 11.7 at 45 weeks. tbg varied from 3.1 to 11.4 mg/dl but showed no correlation with gestational age. there was a positive correlation between t4 and tbg. serum tsh levels showed a significant negative correlati ... | 1977 | 404412 |
| [changes in the thyroid hormone system with combined anticonvulsion treatment of epileptic children and adolescents (author's transl)]. | anticovulsant combined treatment produces statistically significant reduction of total thyroxine, free thyroxine and protein-bound iodine. total cholesterin is significantly raised on average of the total. basal concentration of thyreotropic hormone is slightly lowered. the extent of changes is rather greater than with valproat-, diphenylhydantoin- and primidon permanent treatment; it corresponds with that seen in long term carbamazepin treatment. no definite combinations of anticonvulsants coul ... | 1977 | 404461 |
| [thyroid activity in patients with myasthenia]. | in 27 patients with myasthenia thyroid function tests were done using radioassay methods. the levels of thyroxine (t4), triiodothyronine (t3), thyroxine-binding protein (bt4) and thyrotrophic hormone (tsh) were determined simultaneously in the serum. in 4 myasthenics the levels of t3 and t4 were determined after administration of exogenous tsh (ambinon). the control group comprised 13 subjects without thyroid function disturbances. the investigations demonstrated a statistically significant decr ... | 1977 | 404582 |
| changes in serum levels of thyroxine and thyroxine-binding proteins (tbg, tbpa, albumin) induced by venous stasis. | serum concentrations of thyroxine (t4), thyroxine-binding globulin (tbg), thyroxine-binding pre-albumin (tbpa) and albumin were determined in 21 healthy, young subjects before and after a brief venous stasis in two experiments: 1) 3 min stasis induced by a sphygmomanometer with constant pressure 20 mmhg above the diastolic blood pressure and 2) 2 min stasis induced by an arm tourniquet of rubber. in both experiments the serum t4 level was significantly rised (mean 9%) after venous compression. i ... | 1977 | 404816 |
| testing thyroid function. | from the foregoing discussion, it is clear that no single test provides sufficient information to justify its use alone as a single screening test. in vitro tests have now replaced in vivo procedures in the vast majority of patients. because of the frequency of abnormalities in tbp concentration, the estimation of total t4 should be accompanied by a t3 resin uptake to provide the free thyroxine index or alternatively, a normalized t4 test (quantisorb or etr) is preferable. in patients with susp ... | 1977 | 404998 |
| [the influence of etiroxat-hcl on iodine metabolism in man (author's transl)]. | investigation of the iodine metabolism in man during and after the ingestion of d,l-methyl-3,5,3,5-tetraiodothyronine-ethylester-hydrochloride (etiroxat-hydrochloride, skleronorm) exhibited the following results: 1. after 20-40 mg of etiroxat the absolute iodine uptake of the thyroid gland was increased 3-7 times. there was indirect evidence that the incretion rate of thyroid hormones did not change. 2. the concentration of total iodine, t4(d), t4(ria) and t3(ria) was artificially increased by e ... | 1977 | 405021 |
| immunological and biological characteristics of a new trf analogue, l-pyroglutamyl-l-histidyl-l-pipecolic acid amide. | the immunological and biological potencies of a new synthetic trf analogue, l-pyroglutamyl-l-histidyl-l-pipecolic acid amide, were compared with those of trf. in a radioimmunoassay system for trf, parallel inhibition curves were obtained with trf and the analogue, the immunological potency of the latter being approximately 50 per cent of the former. in vitro and in vivo tsh-releasing activities of the analogue were almost equal to those of trf. as was observed with trf, the in vitro tsh-releasin ... | 1977 | 405206 |
| tbg-dependency of age related variations of thyroxine and triiodothyronine. | thyroxine (t4), triiodothyronine (t3) and thyroxine-binding globulin (tbg) were determined in healthy individuals ranging in age from newborn to 95 years. t4: 10.25 +/- 1.62 microng/100 ml, t3: 1.62 +/- 0.35 ng/ml and tbg: 1.34 +/- 0.15 mg/100 ml, were found elevated until puberty compared to a middle age group with t4: 7.27 +/- 2.26 microng/100 ml, t3: 1.15 +/- 0.24 ng/ml and tbg: 0.98 +/- 14 mg/100 ml. t4 and t3 followed almost tbg concentration. in old age is dissociation between t4: 5.79 +/- ... | 1977 | 405301 |
| serum thyroxine-binding globulin: determination by competitive ligand-binding assay in thyroid disease and pregnancy. | serum thyroxine-binding globulin (tbg) concentrations were measured by competitive ligand-binding assay in normal subjects and patients with a variety of abnormalities of thyroid hormone production or tbg production. the mean serum tbg concentration in 73 normal adults was 3.4 +/- 0.6 mg/100 ml. no correlations with age, sex or serum thyroxine (t4) or triiodothyronine (t3) concentrations were found. serum tbg concentrations were normal in patients with hyperthyroidism. they were significantly el ... | 1977 | 405833 |
| the thyrotrophin response to thyrotrophin releasing hormone during treatment in patients with graves' disease. | thyrotrophin releasing hormone (trh) tests were performed at 4 or 8 weeks intervals, after the initiation of anti-thyroid treatment in 15 patients with graves' disease. all trh test were negative as long as the serum levels of thyroxine (t4) and triiodothyronine (t3) were elevated, and normalization of the serum levels of these hormones always occurred before the response to iv trh was restored. in 13 patients the time from the patients for the first time were registered as biochemically euthyro ... | 1977 | 405834 |
| effect of thyrotrophin releasing hormone (trh) in patients with pituitary disorders. | the secretion and biological activity of thyroid stimulating hormone (tsh) were studied in 22 patients with a pituitary tumour (17 acromegalics and 5 patients with a chromophobe adenoma) and in 36 hypophysectomized patients (16 acromegalics and 20 with a chromophobe adenoma). thyroid function was assessed by serum thyroxine (t4), serum triiodothyronine (t3), and thyroxine-binding globulin (tbg) concentration. serum tsh was measured before and after injection of tsh releasing hormone (trh), and i ... | 1977 | 405835 |
| intravenous and peroral trh stimulation in sporadic atoxic goitre. | thyrotrophin releasing hormone (trh) stimulation test with 200 microng iv was performed in 35 patients with atoxic sporadic goitre. in 23 patients with diffuse goitre 7 showed a lack of increase in serum thyrotrophin (tsh) at a significantly increased frequency compared to controls (p = 0.0028). in 4 patients with solitary nodules 2 showed no significant response to trh (negative), while 3 of the 8 patients with multinodular goitres had negative trh test. only 6 of the 12 trh negative patients a ... | 1977 | 405836 |
| goitres in rats fed polychlorinated biphenyls. | rats fed a polychlorinated biphenyl (pcb) mixture in a high- or low-iodine diet (hid or lid respectively) for 15 days had thyroid enlargement, low serum thyroxine (t4), and high serum thyrotropin concentrations. although binding of thyroid hormones to serum proteins was reduced in pcb-fed animals, the free t4 index (reflecting free t4 in serum) was less in these rats. both serum triiodothyronine (t3) and the free t3 index were elevated in rats fed pcb in hid. lid-maintained rats elevated serum t ... | 1977 | 406020 |
| suppression of elevated serum tsh levels in hypothyroidism by fusaric acid. | the effect of fusaric acid (fa), a specific inhibitor of dopamine beta-hydroxylase, on humna tsh and thyroid hormone concentration (t4 and t3) was evaluated. healthy subjects showed no significant changes in serum t3,t4 and tsh concentrations following the administration of fa calcium salt (fa-ca) or placebo. similarly, administration of fa-ca for 4 weeks to hypertensive patients failed to produce significant changes in the serum t4 or t3 resin sponge uptake values, and in the tsh and t3 respons ... | 1977 | 406275 |
| comparison of preventive effect of t3 and t4 on thyroxine release from thyroid induced by endogeneous tsh after trh injection. | comparison of preventive effect of t3 and t4 on thyroxine release from thyroid induced by endogenous tsh after trh injection. endocrinologia experimentalis 11, 91-98, 1977. the technique of frequent blood sampling through polyethylene tubings inserted into blood vessels while maintaining isovolemia was used in pentobarbiturate anaesthetized rats weighing 250--300 g. the animals were fed low iodine diet for 4 weeks and injected 125i- (5 microgram ci per animal daily) for 6 days begining from 8th ... | 1977 | 407068 |
| serum t4, tbg, t3 uptake, t3, reverse t3, and tsh concentrations in children 1 to 15 years of age. | 1977 | 407237 | |
| effect of prolonged oral administration of trh on plasma levels of thyrotrophin and prolactin in normal individuals and in patients with primary hypothyroidism. | forty mg trh/day was given orally for 3 weeks to 10 euthyroid women and 10 women with primary hypothyroidism on low replacement doses of thyroxine. once weekly oral trh was replaced by an iv trh-test (0.4 mg) with measurement of serum concentration of tsh, prolactin (prl), thyroxine (t4), triiodothyronine (t3) and cholesterol. in the normal group, mean serum t4 concentration increased after one week and remained elevated. serum tsh concentration showed a slight tendency to decline. maximal rise ... | 1977 | 407759 |
| serum total and free thyroxine and triiodothyronine during dynamic muscular exercise in man. | the effect of strenuous dynamic muscular exercise on serum-free thyroxine (ft4) and free triiodothyronine (ft3) concentrations has been studied in 10 healthy subjects. in the course of 7.8-19 min of treadmill exercise (protocol of r. a. bruce), the group showed a mean increase in serum albumin concentration of 11.4% (p less than 0.01). five subjects demonstrated an increase in ft4 concentrations (x = +54%) and five showed decreased ft4 (x = -36%). the difference in ft4 concentrations was account ... | 1977 | 407805 |
| [t4, t3, tsh, hgh in anorexia nervosa--trh-lh-rh loading test]. | 1977 | 408062 | |
| changes in the t4/t3 molar ratio following thyrotropin releasing hormone injection in cattle. | the injection of thyrotropin releasing hormone into cattle resulted in a rapid decrease in the t4/t3 molar ratio. 2 breeds of cattle, shorthorn and africander cross were studied. the decrease in the t4/t3 molar ratio was significantly greater in the shorthorn breed. it is concluded that acute stimulation of the thyroid gland with trh results in enhanced release of both t3 and t4 and that t3 is discharged more rapidly than t4. | 1977 | 408182 |
| effect of bromocryptine on the secretion of thyrotropic hormone (tsh), prolactin (pr), human growth hormone (hgh), thyroxine (t4) and triiodothyroxine (t3) in hypothyroidism. | bromocryptine (cb-154) virtually abolished the rise of serum pr after trh stimulation in hypothyroid and euthyroid subjects. the response of serum tsh to trh stimulation was significantly depressed in hypothyroid but not in euthyroid subjects. no significant changes of serum hgh, t4 and t3 after cb-154 were observed. the dual mode of action of cb-154 in pituitary and hypothalamus is discussed. | 1977 | 408253 |
| the thyroidal t4/t3 ratio in autonomous adenomas: correlation with presurgical thyroid status and iodine content. | 1977 | 408255 | |
| [reduced radiation sensitivity of hyperthyroid goiter with endocrine ophthalmopathy (author's transl)]. | the therapeutic success of fractionated radioiodine treatment of hyperthyroid patients with and without endocrine ophthalmopathy is examined. to achieve a stable euthyroid metabolism, patients with endocrine ophthalmopathy generally need a greater number of treatments with a necessarily higher total dose of radioiodine and longer duration of treatment than hyperthyroid patients without endocrine ophthalmopathy. the average age, the average uptake of 131l and the serum concentration of free t4 we ... | 1977 | 408626 |
| [studies on the binding capacity of thyroxin-binding globulin (tbc), total thyroxin (t4), free thyroxin index (ft4-i) and the etr-test in gestosis and placental insufficiency]. | total serum thyroxine (t4), thyroxine binding capacity (tbc), free thyroxine index (ft4-i) and effective thyroxine ratio (etr) were measured in 53 toxemias of pregnancy and in 5 cases with placental insufficiency. total serum thyroxine, etr and ft4-i were found in physiological ranges of the normal pregnancy, the tbc-index was decreased. between the 19. and 34. week of pregnancy, the decrease of the tbc-index was smaller than after the 34. week of pregnancy. | 1977 | 409000 |
| pituitary-thyroid responsiveness to thyrotropin-releasing hormone in preterm and small-for-gestational age newborns. | a dose of 40 microgram trh was injected intravenously in 12 preterm (pt) and 15 small-for-gestational age (sga) babies (with advanced gestational ages) between 5 and 167 hours after birth. serum-thyrotropin (tsh) was measured prior to and 30 and 180 min after trh; serum-thyroxine (t4) and serum-triiodothyronine (t3) were measured prior to and 180 min after trh. the percentage increase in serum-tsh in pt and sga babies was comparable to that of fullterm newborns. the serum-tsh 30 min after trh in ... | 1977 | 409097 |
| the practical use of thyroid function tests. | the diagnosis of thyroid disorders can usually be established by two tests: the serum t4 and the resin t3 uptake (rt3u). the t4 test measures both free and bound thyroxine; the rt3u reflects the number of binding sites available on thyroid-binding globulin. the values of these two tests can be used to calculate a free thyroxine index (fti), which gives an approximation of the free t4 in the serum. measurement of thyroid-stimulating hormone (tsh) is useful for the diagnosis of hypothyroidism, whi ... | 1977 | 409266 |
| hypothyroidism and amenorrhea due to hypothalamic insufficiency. a study in four young women. | four women, aged 17 to 23, were evaluated for secondary amenorrhea of 12 to 36 months' duration. all were considered to have hypothalamic hypothyroidism on the basis of low thyroxine (t4) concentrations, inappropriately low thyrotropin (tsh) levels, with a normal tsh response to thyrotropin-releasing hormone (trh, 500 microgram intravenously) in three, and absence of a pituitary lesion. nevertheless, menses did not resume after adequate replacement with thyroid hormone. investigation of the pitu ... | 1977 | 409287 |
| [the effect of primidone treatment of thyroid hormones in epileptic children and adolescents (author's transl)]. | in primidon-treated patients there are significantly decreased serum concentrations of total and free thyroxin, protein bound iodine and base line serum tsh values. in primidon-treated children t3-resin test values, concentration of thyroxin-binding protein and total cholesterol are identical to those of the control group. degree of diminution in serum concentration of protein bound iodine, total and free thyroxin and base line tsh was independant of the primidon dose per day. probably the demon ... | 1977 | 409930 |
| functional modifications of the translational system in bacillus subtilis during sporulation. | extracts of sporulating cells were found to be defective in vitro translation of phage sp01 ribonucleic acid (rna) and vegetative bacillus subtilis rna. the activity of washed ribosomes from sporulating cells was very similar to that of washed ribosomes from vegetative cells in translating polyuridylic acid, sp01 rna, and vegetative rna. the s-150 fraction from either vegetative or sporulating cells grown in difco sporulation medium contained an apparent inhibitor of protein synthesis. the crude ... | 1977 | 410778 |
| nucleotide sequence of an arginine transfer ribonucleic acid from bacteriophage t4. | the nucleotide sequence of a phage t4-coded low molecular weight rna, previously designated polyacrylamide gel band epsilon, has been determined. this rna can be arranged in the cloverleaf configuration common to trnas, with an anticodon sequence, u-c-u, which corresponds to the arginine-specific codons a-g-a and a-g-g; it is therefore assumed to be an arginine trna. the complete nucleotide sequence of this rna species is: pg-u-c-c-c-g-c-u-g-g-u-g-u-a-a-u-gm2'-g-a-d-a-g-c-a-u-a-c-g-a-u-c-c-u-u-c ... | 1977 | 410812 |
| alterations in basal and trh-stimulated serum levels of thyrotropin, prolactin, and thyroid hormones in starved obese men. | to investigate further the alterations in pituitary-thyroid function seen during starvation, we have measured basal and trh-stimulated serum levels of thyrotropin (tsh), prolactin (prl), growth hormone, thyroxine (t4), triiodothyronine (t3), free t4, free t3, and reverse t3 during prolonged fasting in seven obese men. fasting was associated with a significant decrease in serum (4, (3, and free t3, while there was an increase in serum reverse t3; these values tended to return toward pre-fast leve ... | 1977 | 410822 |
| [hormone replacement in patients with carcinoma of the thyroid (author's transl)]. | 82 patients with well-differentiated thyroid carcinoma had been treated by total thyroidectomy and radioiodine destruction of any residual thyroid tissue. they were then given high doses of l-thyroxine (t4), enough to suppress endogenous stimulation by tsh, the recommended dose being at least 300 microgram daily. six weeks after starting 150 microgram t4 daily there was no significant response to 400 microgram trh i.v. in 56% of the 82 patients. the t4 dose was then increased until all trh tests ... | 1977 | 411647 |
| inhibition of thyrotrophin-releasing hormone responsiveness by physiological concentrations of thyroid hormones in the cultured rat pituitary gland. | diced quarter anterior pituitaries from mature females wistar rats were cultured in synthetic medium with or without added serum. using each culture as its own control, the thyrotrophin-releasing hormone (trh) dose-thyrotrophin (tsh) response characteristics of both media were similar; significant tsh secretion being stimulated at trh doses around 1-5 x 10(-9) mol/l. during days 1-3 of culture, basal tsh secretion fell significantly but trh responsiveness was unchanged. neither tri-iodothyronine ... | 1977 | 411865 |
| thyroidal and peripheral production of thyroid hormones. review of recent findings and their clinical implications. | there are two biologically active thyroid hormones, thyroxine (t4) and triiodothyronine (t3). most t3 is produced extrathyroidally, so that alterations in circulating thyroid hormone concentrations may occur as a result of both thyroidal and extrathyroidal abnormalities. extrathyroidal t4 conversion to t3 is decreased in patients with different acute and chronic illnesses. when t4 conversion to t3 is impaired and serum t3 concentrations decline, serum concentrations of biologically inactive 3,3' ... | 1977 | 412452 |
| results of integrated management of supraglottic carcinoma. | between january 1957 and june 1974, 173 patients with carcinoma of the supraglottic larynx were treated by an integrated approach at the university of california in san francisco. the policy was to use radiotherapy or surgery alone for stage i and ii disease, radiotherapy combined with either supraglottic laryngectomy or total laryngectomy for resectable stage iii and iv disease, and radiotherapy alone for advanced unresectable disease. control of the disease in the primary site was achieved in ... | 1977 | 412582 |
| carcinomas of the paranasal sinuses: a study of sixty-six cases. | the therapy records of 66 patients with carcinomas of the paranasal sinuses were reviewed; primary carcinomas occurred in the maxillary sinus in 50 patients, the ethmoid sinus in 11 patients, the sphenoid sinus in 4 patients and the frontal sinus in 1 patient. the tumors of the maxillary sinus were staged retrospectively according to the american joint committee staging system recommended in 1976; 1 of 2 patients with t1, 5 of 11 patients with t2, 10 of 34 patients with t3 and 1 of 3 patients wi ... | 1977 | 412586 |
| response to thyrotrophin-releasing hormone and triiodothyronine suppressibility in euthyroid multinodular goitre. | in twenty-two female patients with euthyroid multinodular goitre of varying size, thyroid suppression of 131i thyroid uptake by triiodothyronine (t3) and thyrotrophin (tsh) release after thyrotrophin-releasing hormone (trh) administration were compared with thyroid weight, estimated by a planimetric method, and with serum thyroxine (t4) and t3 concentrations. maximal increment of tsh (deltatsh) after trh and per cent t3-suppressibility were inversely related to thyroid weight and not related to ... | 1977 | 412627 |
| endocrine regulation of fetal development and its relation to parturition in the rhesus monkey. | rhesus monkey fetuses were surgically prosencephalectomized (type 2) or functionally hypophysectomized (type 1) at 75 days gestation, then returned to the uterus until elective caesarean section on day 145--150 (term 167 days). deprivation of fetal hypothalamic releasing factors in type 2 and fetal pituitary tropic hormones in type 1 significantly delayed the ontogeny and functional development of fetal endocrine tissues. bone ossification and growth were significantly retarded in type 1 only, n ... | 1977 | 416938 |
| release of enzymes from human leucocytes during incubation with neisseria gonorrhoeae. | 1977 | 414817 | |
| [levels of total plasma thyroxine (t4) and thyrotropin (tsh) in response to the intravenous administration of thyrotropin-releasing hormone (trh). response of t4 and tsh to trh]. | 1977 | 414311 | |
| a counting method for determining the burst size of defective phages from bacillus subtilis. | the defective phages of bacillus subtilis cannot be counted by plating as they do not form plaques. in addition, counting under the electron microscope with latex spheres as an internal standard is not possible. the reliability of a method using escherichia coli phage t4 as a substitute for the latex spheres has been tested and the results compared with those of other methods. using this method, we determined the burst sizes of the defective phages pbs x, pbs y and pbs z under various conditions ... | 1977 | 414658 |
| preliminary results using twice-a-day fractionation in the radiotherapeutic management of advanced cancers of the head and neck. | twenty-four cases of advanced t4 cancers of the head and neck were treated using a twice-a-day treatment fractionation delivering a 1,200 rad weekly tumor dose and 7,000 rad total tumor dose in 5 1/2-6 weeks. acute normal mucosal reactions and skin reactions were plotted weekly and corresponded to reactions observed when delivering 1,000 rad per week in five treatment sessions. chronic problems have been limited to severe neck fibrosis appearing in three of five patients who underwent a planned ... | 1977 | 413365 |
| a reassessment of 8-anilino-1-naphthalene sulphonic acid as a thyroxine binding inhibitor in the radioimmunoassay of thyroxine. | the effectiveness of 8-anilino-1-naphthalene sulphonic acid (ans) in the radioimmunoassay (ria) of thyroxine (t4) as an inhibitor of the binding of t4 to serum t4-binding proteins is assessed. the optimum ans concentration is dependent upon the antiserum and the method used for separating free and bound t4. if t4 binding to serum proteins is not completely inhibited, resin separation methods may yield low values, while polyethylene glycol and double-antibody methods may produce high values for t ... | 1977 | 413468 |
| [modifications of t3, t4, tsh in thyrotoxic crisis and in thyrotoxic coma after treatment with i131]. | 1977 | 416838 | |
| comparison of the biological effects of thyroxine and triiodothyronine in the rat. | to compare the biological effects of thyroxine (t4) and triiodothyronine (t3), the results of varying the production rates of t3 and t4 independently were evaluated. in one set of experiments, the responses of hypothyroid rats to thyroid hormones were measured in terms of weight gain, hepatic mitochondrial alpha-glycerophosphate dehydrogenase (alphagpd) and serum tsh. t4 was given with, and without, 6-n-propylthiouracil (ptu) and alphagpd activity paralleled, and could completely be accounted fo ... | 1977 | 556986 |
| [clinical and experimental studies of serum thyroxine concentration by t4-ria pac]. | 1977 | 557665 | |
| [measurement of blood thyroxine (t4) levels by ria-mat t4]. | 1977 | 558069 | |
| [measurement of serum t4 by competitive protein binding analysis: tetrasorb e kit]. | 1977 | 558073 | |
| [experimental and clinical studies of ria-mat t4 kit]. | 1977 | 558840 | |
| [studies of rcc (radiochemical center) t4 radioimmunoassay kit (t4 ria pack)]. | 1977 | 558846 | |
| the effect of triiodothyronine on 2-deoxy-d-(1-3h)glucose uptake in cultured chick embryo heart cells. | the uptake of 2-deoxy-d-[1-3h]glucose ([1-3h]dog)by cultured chick embryo heart cells was stimulated by exposure to triiodothyronine (t3). the concentration of free t3 for half maximal stimulation of [1-3h]dog uptake was 8.7 x 10(-10)m. nuclear binding studies revealed that the kd for t3 was 4.2 x 10(-10)m. the molar potencies of other thyroactive compounds in stimulating [1-3h]dog uptake, relative to l-t3, were: 500% for 3'-isopropyl-3,5-diiodo-l-thyronine, 20% for l-thyroxine (t4), 17% for d-t ... | 1977 | 558872 |
| [determination of the serum thyroxine level with riamat t4 kit]. | 1977 | 559566 | |
| [experimental and clinical studies of ria-mat t4 kit]. | 1977 | 559840 | |
| [experimental and clinical studies on thyroxine determination with a new thyroxine radioimmunoassay kit, t4 ria pack]. | 1977 | 560265 | |
| [tri-iodine-thyronin (t3)-hyperthyreosis (author's transl)]. | report on a girl aged 12 years and 2 months and a boy aged almost 14. the first always had normal t4- with always raised t3, belongs, therefore, to the entity t3-hyperthyreosis described by hollander in 1968. the boy had clear clinical signs of hyperthyreosis, but was untreated for 14 months, because a nuclear medical institute had found t4 to be normal and did not investigate t3. one suspects that proper treatment would have been given, if t3 would have been examined early. discussion of the en ... | 1977 | 561268 |
| hypoliquorreic headache and pneumocephalus caused by thoraco-subarachnoid fistula. | one month after having a right upper lobectomy to remove a squamous cell carcinoma, a 43-year-old man presented with a 4-day history of postural headache, worsened by standing and relieved by lying. skull films showed prominent ventricular pneumocephalus. iophendylate myelography was unrewarding, but isotope cisternography revealed a csf fistula at the t4 level, extending into the thoracic cavity. thoracoplastic removal of the first four ribs successfully prevented air passage and the patient ha ... | 1977 | 561915 |
| in vivo functional interaction between dna polymerase and dcmp-hydroxymethylase of bacteriophage t4. | some mutations in the structural gene for t4 dna polymerase (gene 43) behave as suppressors of a deficiency in t4 dcmp-hydroxymethylase (gene 42). the suppression appears to involve a functional interaction between the two enzymes at the level of dna replication. the hydroxymethylase deficiency caused dna structural abnormalities in replication, and dna polymerase lesions appeared to partially reverse these abnormalities. the results do not necessarily imply protein-protein interactions between ... | 1977 | 562423 |
| evaluation of sodium l-thyroxine (t4) requirement in replacement therapy of hypothyroidism. | sodium-l-thyroxine (t4) was utilized in the treatment of 15 pediatric patients with hypothyroidism. adequacy of replacement therapy was confirmed by clinical evaluation in conjunction with determination of serum thyroxine, tri-odothyronine, and thyrotropin concentrations. daily dose of thyroxine capable of including clinical and biochemical euthyroidism ranged from 2.5 to 5 mug/kg of body weight with a mean of 3.5 +/- 0.3 mug in the 4- to 17-year-old age group. two infants with congenital hypoth ... | 1977 | 576137 |
| transient recurrence of hyperthyroidism after delivery in graves' disease. | four patients with graves' disease whose hyperthyroidism was in remission following antithyroid therapy were studied without any treatment during and after pregnancy. in the 8-9th month of pregnancy, they were in a euthyroid state with serum levels of thyroxine (t4) of 18.9, 11.9, 11.2 and 14.5 mug/100 ml, triiodothyronine (t3) of 273, 190, 162 and 244 ng/100 ml and t3 resin sponge uptake (rt3u) of 22, 14, 19 and 16% respectively (normal pregnant range: t4, 7.0-15.0, t3 140-250, rt3u 15-25). at ... | 1977 | 576228 |
| secretion of thyroxine, 3,5,3'-triiodothyronine and 3,3'5'-triiodothyronine in euthyroid man. | the secretion of iodothyronines from the normal human thyroid gland was assessed by radioimmunoassay analyses of the concentrations of thyroxine (t4), 3,5,3'-triiodothyronine (t3) and 3,3',5'-triiodothyronine (reverse t3, rt3) in thyroid venous and peripheral venous blood. the subjects studied were euthyroid patients undergoing parathyroid surgery. measurements were carried out both under apparently normal conditions, following peroral t3 pre-treatment, and before and after acute administration ... | 1977 | 576344 |
| effect of increased iodide intake on thyroid function in subjects on chronic lithium therapy. | thyroid function tests were obtained in 10 patients on chronic lithium therapy before and after the administration of potassium iodide 250 mg q.i.d. mean serum tsh rose by 8.9 muu/ml and mean serum t3 rose from 70 to 101 ng/dl. two patients became hypothyroid; a third showed a rise in tsh without any change in t3 or t4. a fourth patient developed hyperthyroidism probably secondary to the jod-basedow phenomenon. pharmacologic doses of iodine should be administered with caution to patients on chro ... | 1977 | 576345 |
| a microgel electrophoretic analysis the colloid in single rat thyroid follicles during thyroxine suppression. | a sequential study of the effect of thyroxine (t4) on the protein composition of the colloid in the rat thyroid gland has been carried out in 24 rats. daily ip injections of 20 mug thyroxine were given and the colloid was analyzed after 1, 2, 3 and 4 days and 1, 2 and 3 weeks. the protein constituents were separated by microgel electrophoresis and measured by microdensitometry. the incorporation of [3h]leucine into the thyroglobulin fraction and into the albumin-like protein in the homogenate of ... | 1977 | 576346 |
| ophthalmic graves's disease: natural history and detailed thyroid function studies. | of 27 patients with ophthalmic graves's disease (ogd) who had been clinically euthyroid three years previously, one became clinically hyperthyroid and seven overtly hypothyroid. improvement in eye signs was associated with a return to normal of thyroidal suppression by triiodothyronine (t3) and of the response of thyroid-stimulating hormone (tsh) to thyrotrophin-releasing hormone (trh). of a further 30 patients with ogd who had not been studied previously, three were overtly hypothyroid. of the ... | 1977 | 576414 |
| plasma thyroxine, 3,3',5-triiodothyronine and 3,3',5'-triiodothyronine during beta-adrenergic blockade in hyperthyroidism. | plasma thyroxine (t4), 3,3',5-triiodothyronine (t3) and 3,3',5'-triiodothyronine (rt3) were measured in 16 patients with graves' disease. patients were studied under the following conditions: first without any treatment, then, during beta-adrenergic blockade with propranolol, and finally after euthyroidism had been attained by carbimazole. during propranolol t3/t4 ratio decreased, whereas t4 remained unchanged. after carbimazole t3/t4 ratio returned to its pretreatment value. rt3/t4 ratio showed ... | 1977 | 576870 |
| value of simultaneous t3, t4, and tsh measurements for management of graves' disease in children. | one hundred simultaneous determinations of serum t4 and t3 were performed during the course of treatment of 23 children and adolescents with graves' disease. five patients were previously untreated and six were experiencing relapse after treatment was discontinued. during relapse, increased t3 concentration is frequently present when serum t4 concentration is normal and t3 measurement is therefore more reliable for early detection of relapse. during therapy with thionamides, t4 measurement alone ... | 1977 | 577011 |
| influence of experimental hyperthyroidism on skeletal muscle metabolism in the rat. | in this study hind-limb perfusion was used to investigate the influence of thyroid hormones on some metabolic parameters in the skeletal muscle of the rat. daily injection of 20 microng l-thyroxine (t4) per 100 g b. w. for a week caused a 25% increase in oxygen consumption. further enlargement of the t4 dose had little additive effect. in the dose range 20--80 microng t4/100g b.w., no important changes occurred in lactate production or glucose consumption. only at the highest t4 dose did the glu ... | 1977 | 577081 |
| transplantable thyroid tumour in rats: iodoamino acid distribution in successive tumour generations. | all first generation thyroid tumours in rats, produced by 3 micronc 131i followed by lid, were uniformly functional containing mit, dit, t4, t3, and in some cases, t'3. all fourth generation tumours were nonfunctional as tested. second and third generation tumours were biochemically unpredictable, some containing all iaa including t'3, others only mit, i-and a trace dit. degree of dedifferentiation and of autonomy did not necessarily correlate with loss of function. results could be explained by ... | 1977 | 577083 |
| thyroid hormone-binding interactions in cytosol of rat anterior pituitary. | thyroxine (t4) and triiodothyronine (t3)-binding interactions in preparations of rat anterior pituitary gland have been studied. t4 is bound primarily to extranulcear binding sites located in the cytosol fraction of the cell. these sites have a medium affinity for t4: ka = 2.5 x 10(8) 1/mol and a maximum binding capacity (mbc) of 1.15 pmol/mg tissue (wet weight). binding of t3 to these sites is minimal. the extent of binding of t4 is influenced by the ph of the system and the temperature of incu ... | 1977 | 577324 |
| divergent effects of 6-propylthiouracil on 3,3',5'-triiodothyronine (rt3) serum levels and in man. | the effect of 6-propylthiouracil (ptu) on the peripheral conversion of thyroxine (t4) to 3,5,3'-triiodothyronine (t3) and 3,3',5'-triiodothyronine (reverse t3 rt3) was investigated by assessments of the concentrations of t4 t3 and rt3 in peripheral venous blood from t4-treated healthy volunteers given ptu, 4 x 150 mg daily. within on day of ptu administration, serum t3 concentrations were reduced, and those of rt3 enhanced. these deviations lasted as long as ptu was given (five days), and there ... | 1977 | 577326 |
| in vivo studies on thyroxine and triiodothyronine metabolism in the rat. | the reciprocal effects of loading amounts of thyroxine (t4) or triiodothyronine (t3) on the in vivo deiodination of their 125i-labelled isotopes by the rat were studied. it was found that the deiodination of a tracer amount of [125i]t3 as measured by the 24-h urinary 125iodide was significantly decreased after administration of a loading dose of non-radioactive t4. a similar decrease in deiodination of [125i]t3 was observed following the injection of a t3 load. in experiments in which the deiodi ... | 1977 | 577327 |
| reversible plasma and red blood cells volumes increases in acromegaly. | plasma volume (pv) and red blood cells volume (rbcv) were measured in 76 normotensive acromegalic patients (42 males and 34 females) and compared with those of 28 controls on the basis of body surface. in untreated males pv and rbcv were significantly higher than in normals (p less than 0.001) and total blood volume (tbv) was above the normal range in 85%. untreated females also showed an elevated pv but had significantly lower rbcv than the male patients. the only vascular volume of the patient ... | 1977 | 577334 |
| stimulation of peripheral t3 formation by oral but not by intravenous glucose administration in fasted subjects. | fasting is known to promote a shift in the conversion of thyroxine (t4), more being deiodinated to an inactive form, reverse triiodothyronine (rt3), and less to active triiodothyronine (t3). the mechanism behind this change is not known, but it has recently been demonstrated that the proportion of dietary carbohydrates influences the serum concentration of t3 and rt3. therefore, it is possible that the deiodination of t4 is subordinated to gastroenterohepatic regulation. to explore this possibil ... | 1977 | 577337 |
| rapid disappearance of loading doses of thyroxine from blood and their excretion by the bile in rats. | the disappearance of loading doses of thyroxine (t4) (100-20 000 microng t4 iv per rat weighing about 400 g) was measured with the aid of new technique allowing frequent blood sampling with maintenance of isovolaemia in anaesthetized animals. it was found that as early as 2 min after the injection more than half of the administered dose disappeared from the blood, while after 300 min only about 2% of that remained in the plasma. the direct relationship between the administered dose of t4 and bot ... | 1977 | 577338 |
| thyroxine toxicosis in patients with iodine induced thyrotoxicosis. | serum concentrations of thyroxine (t4) and triiodothyronine (t3) were measured in 74 untreated hyperthyroid patients. of these, 47 had graves' disease, 12 had toxic nodular goiter and 15 had iodine induced thyrotoxicosis (iit). the average serum t4 concentrations were, respectively, 13.5 microgram/100 ml and 13.3 microgram/100 ml (normal 4.5-10.3 microgram/100 ml). the average serum t3 concentrations were in the same order 732 ng/100 ml, 505 ng/100 ml and 378 ng/100 ml )normal 116-288 ng/100 ml) ... | 1977 | 577497 |
| reduction of plasma triiodothyronine (t3) induced by propranolol. | the effect of propranolol on plasma triiodothyronine (t3), thyroxine (t4) and triiodothyronine uptake by sephadex g-25 (rt3u%) was studied in fourteen thyrotoxic patients and eight normal volunteers. 40 mg of propranolol as a single oral dose caused significant reduction in total serum t3 which began 60 min after administration. no significant changes were observed in t4 and rt3u% values. plasma t3 levels remained suppressed during a 5 day course of treatment with propranolol. these results sugg ... | 1977 | 577897 |
| [evaluation and clinical application of a new commercial radioimmunoassay kit for serum thyroxine (total t4 (ria), ames company). (author's transl)]. | 1977 | 578325 | |
| t3 toxicosis in children. | triiodothyronine (t3) toxicity has been well documented in adults, but only isolated cases have been reported in children. two girls presented with firm goitres and overt hyperthyroidism. in each patient, total serum thyroxine (t4) values by competitive protein binding were normal, however total t3 values by radioimmunoassay were elevated. one patient had graves' disease, the second patient had hashimoto's disease which has been only infrequently associated with t3 toxicity in adults. both patie ... | 1977 | 578375 |
| [plasmatic thyroid hormones during treatment of hyperthyroidism by carbimazol (author's transl)]. | plasmatic concentrations of thyroxine (t4-d-) and triiodothyronine (t3 ri) were evaluated in 32 graves' diseases on treatment by carbimazol. among 131 measures, t4 and t3 were dissociated in 56%, with t3 more elevated than t4 in 89%. compensated hypothyroidism was frequently seen (35%). | 1977 | 578398 |
| studies on circadian variations of plasma tsh, thyroxine and triiodothyronine in man. | to evaluate the existence of circadian variations in thyroid hormone and tsh levels, blood was drawn every 20 min for 24 h in four and for 14 h in one volunteer. hormones were measured by sensitive radioimmunoassays. tsh: a diurnal rhythmicity could be demonstrated with peaks from 8 p.m. to 2 a.m and a nadir from 7 a.m. to 2 p.m. superimposed on the diurnal rhythm multiple shortlived fluctuations were observed. thyroxine: pooled data showed peak values from 8 a.m. to 12 a.m. and lowest levels fr ... | 1977 | 578614 |
| [investigation of measurement method for serum thyroxine (t4) by radioimmunoassay using polyethyleneglycol (peg) (author's transl)]. | 1977 | 578947 | |
| [determination of thyroxine by t4-riapac and seralute t4-ria kits (author's transl)]. | 1977 | 578961 | |
| [radioimmunoassay of thyroxine by t4-riapac (author's transl)]. | 1977 | 578994 | |
| the thyroid reserve in patients with breast cancer. | patients with breast cancer were studied with regard to changes in the levels of serum thyroxine (t4) and serum triidothyronine (t3) after intramuscular administration of tsh for three days to investigate the thyroid reserve in these patients. the changes were examined also in normal subjects, in patients with hashimoto's thyroiditis and primary hypothyroidism. in primary hypothyroidism no increase was seen in serum t4 and t3 levels after tsh administration, and the thyroid reserve was considere ... | 1977 | 579003 |
| the influence of hypophysectomy on nsila concentrations in the dog: evidence for partially pituitary-independent regulation. | non-suppressible insulin-like activity (nsila) was determined in 5 dogs before and after hypophysectomy. all nsila determinations were carried out on serum samples after acidic sephadex g-50 chromatography by two different assay systems, i.e. a bioassay and a protein binding assay. the levels of nsila decreased significantly after hypophysectomy and returned to near normal levels after 2 weeks. t3-, t4- and cortisol levels were drastically reduced during the entire period of the experiment. seve ... | 1977 | 579020 |
| changes in serum tsh and t4 after t3 suppression tests in patients treated for hyperthyroidism due to graves' disease. | 1977 | 579181 | |
| the relationship of thyroid-stimulating hormone (tsh), thyroxine (t4), and triiodothyronine (t3) in primary thyroid failure. | thyroid-stimulating hormone (tsh), serum thyroxine (t4) and triiodothyronine (t3) in sera of 100 patients with primary thyroid failure were measured by radioimmunoassay. effective thyroxine ratio (etr) was also measured in 69 of these sera. tsh was elevated in all, with a mean of 76.7 +/- 55 micromicron/ml (range 11 to 140 micromicron/ml, and was used to confirm the diagnosis. mean t4 and t3 levels in the group were 1.8 +/- 1.5 microgram/100 ml (range less than 0.2 to 7.0 microgram/100 u.) and 7 ... | 1977 | 579717 |
| measurement of serum tsh and thyroid hormones in the management of treatment of thyroid carcinoma with radioiodine. | 1. serum levels of tsh, thyroxine (t4) and triiodothyronine (t3) have been measured during treatment and follow-up of patients with thyroid carcinoma. 2. serum tsh and thyroid hormone levels were initially normal. three weeks after total thyroidectomy, tsh was elevated in about 50% of patients and after a subsequent therapy dose of 131i it exceeded 30 mu/l in 90% of patients. occasionally, tsh did not rise until after the second dose of 131i. low serum t4 and t3 concentrations were associated wi ... | 1977 | 588901 |
| [serum t4 determination with tetra-tab ria kit]. | 1977 | 589814 | |
| [serum t4 determination with tetra-tab ria]. | 1977 | 589827 | |
| viroimmunoassay utilizing a synthetic peptide: a test equivalent to the carcinoembryonic antigen radioimmunoassay. | a recently developed immunoassay which utilizes the synthetic fragment cea(1-11), corresponding to the n-terminal segment of carcinoembryonic antigen (cea), was used for the evaluation of human sera. the various sera were tested for their capacity to inhibit the inactivation of the modified bacteriophage preparation cea(1-11)-t4 by antiserum prepared against the bovine serum albumin (bsa) conjugate cea(1-11)-bsa. in this immunological system both the free synthetic peptide and a semipurified pre ... | 1977 | 591295 |
| effect of starvation on the production and metabolism of thyroxine and triiodothyronine in euthyroid obese patients. | the metabolic clearance and production rates of thyroxine (t4) and triiodothyronine (t3) were measured in 9 obese euthyroid patients prior to and during prolonged starvation. the metabolic clearance rates (mcr) and serum concentrations of t4, and, therefore, the metabolic degradation or production rates of t4 were undecreased strikingly during starvation, from 145 +/- 7 ng/dl (mean +/- se) to 66 +/- 9 ng/dl (p less than 0.001), while the mean mcr of t3 was unchanged, with the result that t3 degr ... | 1977 | 591624 |
| multiplicity reactivation and repair of nitrous acid-induced lesions in bacteriophage t4. | 1977 | 592384 | |
| studeis on the biochemical basis of mutation. iv. effect of amino acid substitution on the enzymatic and biological properties of bacteriophage t4 dna polymerase. | 1977 | 592387 | |
| studies on the structure, protein composition and aseembly of the neck of bacteriophage t4. | 1977 | 592389 | |
| molecular reorganization in the hexagon to star transition of the baseplate of bacteriophage t4. | 1977 | 592390 |