Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| effect of thyrotoxicosis on gluconeogenesis from alanine in the perfused rat liver. | the influence and mechanism of action of t4 treatment on hepatic gluconeogenesis from alanine was studied in isolated rat livers. conversion of alanine into glucose was increased markedly in livers of thyrotoxic rats compared to that in normal rats. estimation of metabolic intermediates of the gluconeogenic pathway showed that t4 treatment produced forward cross-over between pyruvate and phosphoenolpyruvate, which suggests that this point is a control site. alanine transport into the liver cells ... | 1978 | 217582 |
| the contribution of local tissue thyroxine monodeiodination to the nuclear 3,5,3'-triiodothyronine in pituitary, liver, and kidney of euthyroid rats. | the contributions of local t4 monodeiodination and plasma t3 to the nuclear t3 of anterior pituitary, liver, and kidney were measured in euthyroid rats. after injection of [125i]t4, there was a gradual increase in the quantity of plasma [125i]t3 in excess of injected contaminant, which peaked at approximately 12 h after injection and remained a constant fraction of plasma [125i]t4 (2.8 x 10(-3) after that time. in the nuclei of anterior pituitary tissue, there was also a slow increase in locally ... | 1978 | 217671 |
| an increase of plasma triiodothyronine and thyroxine after administration of dexamethasone to hypothyroid patients with hashimoto's thyroiditis. | in an attempt to study the effect of adrenal steroids on plasma thyroid hormone concentration in patients with hashimoto's thyroiditis, 2 mg dexamethasone was administered for 2-4 weeks to 9 patients with normal plasma tsh, 3 patients with compensatory increase of plasma tsh, and 10 patients with a marked elevation of plasma tsh. dexamethasone depressed plasma t4, t3, and tsh and reduced thyroid size in nine euthyroid patients, whereas a similar treatment did not affect plasma t3 and t4, but red ... | 1978 | 233634 |
| relationship between thyroid status and graves' disease-specific immunoglobulins. | the prevalence of tsi in graves' disease was investigated with a radioligand receptor assay using human thyroid membranes and highly purified labeled porcine tsh or bovine tsh in 110 patients before treatment and in 39 patients after successful treatment with antithyroid drugs. in 11 patients, the assay was performed before, during, and after therapy. the results in the radioligand receptor assay were compared to thyroid function tests (trh test, free t4 index, serum %3 level, and thyroid suppre ... | 1978 | 233668 |
| plasma levels of gonadotropins, prolactin, thyroxine, and adrenal and gonadal steroids in obese prepubertal girls. | plasma levels of gonadotropins, prl, t4, and adrenal and gonadal steroids were measured in two groups of 7- to 9-yr-old and 10- to 11-yr-old obese prepubertal girls, and were compared to those found in groups of nonobese girls of the same age. the data found in normal weight subjects confirm the data reported in the literature, showing a significant rise between the 7- to 9- and 10- to 11-yr groups, of fsh, pregnenolone, dehydroepiandrosterone, testosterone, and estradiol plasma levels, while lh ... | 1978 | 162519 |
| hyperthyroidism without triiodothyronine excess: an effect of severe non-thyroidal illness. | serial changes in thyroid hormone levels are described in two patients in whom hyperthyroidism was associated with transient non-thyroidal illness. in a 74-year-old woman with mild hyperthyroidism, two episodes of cholecystitis were associated with subnormal concentrations of serum t3 and increased concentrations of serum rt3; t3 became elevated during recovery, associated with a simultaneous fall in rt3. the tsh response to trh was undetectable on three occasions. a cholecystectomy was performe ... | 1978 | 109456 |
| in vitro sensitivity of transplantable leukemias to endogenous granuloid (gce, gi-2) and lymphoid (t4, t4-1) inhibitors of proliferation. | the effect on cell proliferation of crude granulocyte and thymocyte extracts (gce, t4) and of their target-specific fractions (gi-2, t4-1) was studied in cultures with transplantable subacute myeloid and lymphoid leukemia (ml, ll). in the dose rage studied (1-500 microgram/ml) each factor reduced 3h-tdr incorporation into acid-insoluble dna of bone marrow, thymus and spleen cells with ml or ll as a function of the dose, approximately linearly. normal bone marrow proved to be less sensitive to gc ... | 1978 | 146844 |
| escherichia coli mutants deficient in deoxyuridine triphosphatase. | mutants deficient in deoxyuridine triphosphatase (dutpase) were identified by enzyme assays of randomly chosen heavily mutagenized clones. five mutants of independent origin were obtained. one mutant produced a thermolabile enzyme, and it was presumed to have a mutation in the structural gene for dutpase, designated dut. the most deficient mutant had the following associated phenotypes: less than 1% of parental dutpase activity, prolonged generation time, increased sensitivity to 5'-fluorodeoxyu ... | 1978 | 148458 |
| the effect of prednisone on serum thyrotropin, thyroxine and triiodothyronine concentrations in hypothyroid patients. | the effect of exogenous prednisone on serum thyrotropin (tsh), thyroxine (t4), and triiodothyronine (t3) concentrations was investigated in four patients with non-functioning thyroid glands receiving t4 replacement therapy. orally administered prednisone, in a dose of 20 mg each day for nine days, resulted in a significant decrease in mean serum tsh levels (p less than 0.01) without significant changes in levels of serum t4, t3, and thyroxine binding globulin (tbg). these findings suggest an inh ... | 1978 | 114570 |
| acute effects of alcohol on anterior pituitary secretion of the tropic hormones. | the plasma or serum concentrations of gh, tsh, lh, prl, testosterone, cortisol, t4, and t3, and the values of the t3 uptake test were monitored in 12 healthy male volunteers for a period of 20 h after administration of one large dose of ethanol (1.5 g/kg bw). the effects of trh and lrh on the secretion of tsh, prl, and lh were studied in these subjects once during the period of acute alcohol intoxication (4 h after the start of drinking) and once during the hangover period (14 h after the start ... | 1978 | 122287 |
| trh test as an index of suppression compared with the thyroid radioiodine uptake in euthyroid goitrous patients treated with thyroxine. | to determine an index of adequate suppression of pituitary tsh secretion in euthyroid goitrous patients treated with sodium levothyroxine (t4), tsh responses to 500 micrograms trh given iv were compared with thyroid 24-h radioiodine uptakes during therapy with t4 in 12 euthyroid goitrous patients. the patients received sequentially 100, 150, 200, 250, and 300 micrograms t4 with the doses increased at 4-6 week intervals. the mean dose of t4 that reduced the peak tsh response to tsh to the lower l ... | 1978 | 122398 |
| effect of thyroid hormones on the prolactin response to thyrotropin-releasing hormone in normal persons and euthyroid goitrous patients. | in nine euthyroid goitrous patients, increasing doses of t4 caused a significant decrease in the prl response to trh; the prl response fell significantly at a dose of t4 of 100 micrograms/day for 1 month (p less than 0.02) and fell further with increasing doses so that at 300 micrograms t4/day, the prl response was 40% of that in the untreated state. t4 treatment also blunted the prl response to chlorpromazine (p less than 0.05) in a separate group of euthyroid goitrous patients. in contrast, th ... | 1978 | 122402 |
| responses to trh and t3 suppression tests in euthyroid subjects with a family history of graves' disease. | the relationship of graves' disease and heredity was studied in 97 clinically and biochemically euthyroid relatives (resin t3 uptake and serum t3, t4, and tsh within normal ranges) who had more than two thyrotoxic relatives within the second degree relationship. trh tests were preformed in all 97 cases. in 56 of the 97, t3 suppression tests were performed shortly after the trh test. results revealed that 29 of the 97 (29.9%) showed an abnormal response to trh. fourteen of these (14.4%) revealed ... | 1978 | 122407 |
| transient trh deficiency after prolonged thyroid hormone therapy. | a patient who had been treated with large doses of thyroid hormone for several years developed features of secondary hypothyroidism after thyroid hormone withdrawal. these findings were low serum t4 (3.8 micrograms/dl), t3 (23 ng/dl), and a failure of serum tsh to rise after trh injection. serum prl values rose normally after trh administration, and evaluation of other pituitary hormones was normal. when retested 3 months later, at which time the serum t4 was 5.5 micrograms/dl, the patient was s ... | 1978 | 122410 |
| reduced thyroid function after thyrotropin stimulation. | the course of serum t4 and t3 return to baseline after tsh stimulation was studied in two groups at six normal subjects over 28 days after im bovine tsh (b tsh; 0.15 u/kg). in the first group of six subjects, serum btsh rose from undetectable levels to a mean peak of 5.6 +/- 0.5 ng/ml (mean +/- se) at 2 h, and fell below detectable levels by 24 h with a t1/2 of 7 +/- 1 h. t4 rose to a peak 59 +/- 10% above basal levels within 24 h, returned to basal levels on day 7, then dropped below basal leve ... | 1978 | 122412 |
| effect of human chorionic gonadotropin on thyroid function in euthyroid men. | the effect of large doses of commercial hcg on thyroid function was studied in eight men who received 100,000 or 150,000 iu hcg iv. these large doses of hcg produced definite thyroidal iodine release (tir) responses in all eight men. the tir after hcg administration was more delayed and of lesser magnitude than the tir responses to tsh and trh. there were no significant changes in serum t4, t3, or tsh for 48 h after hcg administration. no clinical side effects were noted in the subjects after iv ... | 1978 | 122416 |
| comparison between the thyrotropin response to thyrotropin-releasing hormone in summer and that in winter in normal subjects. | a comparison was made between the thyrotropin (tsh) response to 500 microgram thyrotropin-releasing hormone (trh) in summer and that in winter in ten healthy normal adults living in supporo. the serum resin triiodothyronine (t3) uptake (rt3u), thyroxine (t4) and t3 levels were also measured. while the tsh response to trh in summer was similar to that in winter, serum t3 concentration and free t3 index were significantly higher in winter than in summer, associated with the similar values in rt3u ... | 1978 | 109290 |
| serum t3 and t4 concentrations of japanese quail treated with thyrotropin-releasing hormone. | 1978 | 108179 | |
| occult thyroid disease in an elderly hospitalized population. | measurements of thyroxine (t4), triiodothyronine (t3), thyrotropin (tsh), and t3 talc uptake (t3tu) were performed on 425 hospitalized patients over 60 years of age. unsuspected thyroid disease was found in 10 patients (2.4%); 9 were hypothyroid and 1 hyperthyroid. another 11% of the population had abnormal t4 or tsh levels but were not proved to have thyroid disease. repeat measurements in 10 of 40 patients with low serum t4 concentrations showed a return of the tests to normal. the low t4 leve ... | 1978 | 107216 |
| "short" loop feedback regulation of hypothalamic and brain thyrotropin-releasing hormone content in the rat and dwarf mouse. | in order to determine whether t4, tsh, or both affect hypothalamic trh content, primary or secondary hypothyroidism was induced in the rat by thyroidectomy (tx) or hypophysectomy (hx), respectively. two weeks later, rats were treated with t4, tsh, or both for 14--16 days. tx or hx significantly decreased hypothalamic trh content, and t4 treatment restored hypothalamic trh to normal in the tx but not in the hx rats. when tsh was administered simultaneously with t4 to hx rats, hypothalamic trh con ... | 1978 | 107021 |
| [serum iodothyronine concentrations and properties of mitochondria phosphorylative oxidations in old rats]. | serum concentrations of t4 and t3 in 2 year-old rats were decreased by about 30% compared to 2 month-old animals, but rt3 was similar. activities of old rats' liver mitochondria were near those of young thyroidectomized animals. low circulating t3 partly explains metabolic changes observed during senescence. | 1978 | 105818 |
| plasma thyroxine and triiodothyronine levels in spontaneously metamorphosing rana catesbeiana tadpoles and in adult anuran amphibia. | we have developed sensitive and reliable radioimmunoassays for t4 and t3 in amphibian plasma and have used these procedures to measure plasma t4 and t3 levels in spontaneously developing rana catesbeiana tadpoles at various stages of metamorphosis. during premetamorphosis circulating levels of both t4 and t3 were below the limits of detection of the ria procedures (t4 less than 50 ng/100 ml, t3 less than 5 ng/100 ml). a gradual rise in plasma t3 and t4 became apparent during prometamorphosis, an ... | 1978 | 105869 |
| peripheral metabolism of homologous thyrotropin in euthyroid and hypothyroid rats: acute effects of thyrotropin-releasing hormone, triiodothyronine, and thyroxine. | the peripheral metabolism and metabolic clearance rate (mcr) of homologous tsh was studied in euthyroid and hypothyroid rats. incubation of freshly labeled [125i]iodo-tsh with rat serum revealed a labeled nonimmunoreactive protein in the void volume of a sephadex g-100 column which could not be detected by conventional chromatographic purification. removal of this contaminant from the tracer reduced the nonspecific binding in the absence of serum and increased the binding of tracer in the absenc ... | 1978 | 105884 |
| comparison of inhibitory effects of 3,5,3'-triiodothyronine (t3), thyroxine (t4), 3,3,',5'-triiodothyronine (rt3), and 3,3'-diiodothyronine (t2) on thyrotropin-releasing hormone-induced release of thyrotropin in the rat in vitro. | in order to compare, in vitro, the tsh suppressive effects of iodothyronines, rat pituitary quarters were first preincubated with t4, t3, rt3, or 3,3'-diiodothyronine (t2) in gey and gey buffer containing 1% bovine serum albumin for 2 h at 37 c and then incubated at 37 c for 1 h with the iodothyronine under study and trh. tsh released into the medium during incubation was compared to that released by control pituitary fragments, which were not exposed to iodothyronines. all four iodothyronines ( ... | 1978 | 105890 |
| the effect of l-dopa administration on thyrotropin (tsh) and thyrotropin releasing hormone (trh) levels in serum in primary or pituitary hypothyroidism. | the effect of acute administration of l-dopa on tsh and trh levels in serum was studied in primary or pituitary hypothyroidism. trh levels in serum fell and then returned to initial levels after l-dopa administration in primary or pituitary hypothyroidism. tsh levels in serum fell and then returned to initial levels after l-dopa administration in primary hypothyroidism. t4 and t3 levels in serum did not change after l-dopa administration in primary or pituitary hypothyroidism. these data suggest ... | 1978 | 105899 |
| response to thyrotrophin-releasing hormone in atrial dysrhythmias. | seventy-eight clinically euthyroid patients with atrial dysrhythmias, either established or paroxysmal, and sixty-three patients in sinus rhythm with coronary disease were screened for hyperthyroidism using thyroid function tests including the thyroid-stimulating hormone (tsh) response to thyrotrophin-releasing hormone (trh). all had normal levels of serum thyroxine (t4) apart from three with dysrhythmias who were found to have hyperthyroidism. twenty per cent of patients with atrial dysrhythmia ... | 1978 | 105350 |
| thyroid function in long term haemofiltration. | ten patients on haemofiltration treatment for between 4 and 20 months have been screened for thyroid function. comparing serum t3 and t4 levels at the start of haemofiltration and 5 to 20 months later, a continuous decrease was detected (t3-ria: 92 +/- 23 ng% to 68 +/- 23 ng%; t4-ria: 4.94 +/- 1.79 microgram% to 3.81 +/- 1.21 microgram%). serum tsh-ria values also declined in mean from 3.48 +/- 0.47 muu/ml, yet two patients showed an increase as expected with a functioning hypothalamic pituitary ... | 1978 | 105354 |
| effect of carbamazepine, phenytoin and phenobarbitone on serum levels of thyroid hormones and thyrotropin in humans. | patients on long-term treatment with either of the stereochemically related antiepileptic drugs phenytoin (dph) or carbamazepine (cbz) had similar changes in serum thyroid hormone concentrations. t4, ft4, ft4 index, t3, ft3, ft3 index and rt3 were reduced, whereas t3u and tsh were not significantly different from the reference group levels. long-term phenobarbitone treatment had no convincing effect on the investigated parameters when used alone, but possibly potentiated the effect of cbz. in pa ... | 1978 | 105401 |
| the t4/tbg ratio and the investigation of thyroid function. | the relationship between serum thyroxine (t4) and thyroxine-binding globulin (tbg) has been studied in "euthyroid" subjects. the t4/tbg ratios in these subjects has been calculated and compared with those found in patients suffering from myxoedema and thyrotoxicosis. the ratio allows a more precise selection of the borderline cases requiring thyroid stimulating hormone and triiodothyronine assays, particularly when the serum tbg is raised or lowered. | 1978 | 103659 |
| [hyperthyroidism: diagnosis (author's transl)]. | in hyperthyroidism we differentiate two main forms: (1) hyperthyroidism due to basedow's (graves') disease, always characterized by endocrine eye signs, frequently with goiter; (2) hyperthyroidism due to nodular goiter or to plummers' disease, without endocrine exophthalmos. the clinical diagnosis includes typical complaints (e.g., weight loss, heat intolerance, sweating) and findings (e.g., tachycardia, tremor, soft-warm skin). the technical diagnosis includes in vivo (scintigraphy, ri-uptake, ... | 1978 | 104101 |
| comparison of the effect of various doses of thyroxine on jejunal disaccharidases in intact and adrenalectomized rats during the first 3 weeks of life. | administration of d,l-thyroxine (t4) daily (25 or 250 nmol/100 g body weight/24 h) for 4 days increased jejunal activity in 15-day-old rats; no effect was seen in 8-day-old rats. maltase activity was increased in 15-day-old rats only when a 250-nmol dose was used. similar results were obtained in unoperated and adrenalectomized rats. specific activity of lactase was not influenced in unoperated 8- and 15-day-old rats; it was decreased in adrenalectomized 8- and 15-day-old rats when treated with ... | 1978 | 104871 |
| carcinom of the paranasal sinuses--a review of 158 cases. | one hundred and fifty-eight cases of paranasal sinus cancer have been reviewed retrospectively. the actuarial survival at five years for the whole group was 33%. the american joint committee (ajc) classification for maxillary cancer was used. t1 and t2 cases, with an actuarial survival of 44% at five years, had a significantly better prognosis than t3 cases (31%) and t4 cases (10%). anemia of presentation and the presence of persistent disease when surgery followed pre-operative irradiation were ... | 1978 | 105151 |
| an in vitro procedure for the estimation of thyroid hormone releasing factors in sera of thyrotoxic patients. | lats containing sera and a number of graves' disease sera stimulated t4 release from mouse thyroids in vitro as determined by ria, thus confirming the presence of a thyroid hormone releasing factor in sera of thyrotoxic patients. the pattern of stimulation was similar to that previously shown for tsh in terms of t4 release time sequence. camp increase and catecholamine inhibition via alpha-adrenergic receptors. in the same in vitro system, neutralization with a human thyroid homogenate showed pr ... | 1978 | 92490 |
| large molecular weight tsh-beta: the sole immunoactive form of tsh-beta in certain human sera. | the beta subunit of tsh (tsh-beta) usually cannot be detected (less than 0.2 ng/ml) in the serum of normal individuals, whereas patients with primary hypothyroidism exhibit elevated tsh-beta levels (0.2-9.3 ng/ml), which increase further after the administration of trh. two patients were found to have large tsh-beta as the only form of serum tsh-beta immunoactivity. patient a was a euthyroid woman with a goiter; tsh and alpha subunit levels were normal (1 microu/ml and 0.6 ng/ml, respectively); ... | 1978 | 95622 |
| the binding of thyroxine and tri-iodothyronine to plasma proteins in the chicken at the physiological ph. | amounts of 125i-labelled thyroxine (t4) and triiodothyronine (t3), representing approximately 50 per cent of the plasma concentration, were incubated with chicken plasma or serum, the proteins were separated by polyacrylamide gel electrophoresis at ph 7.4 and the distribution of the hormones determined. seventy to 75 per cent of t4 migrated with albumin, about 10 per cent with the alpha-globulin and most of the remainder with a pre-albumin fraction. the percentage attached to the pre-albumin ten ... | 1978 | 86196 |
| low dose lithium-carbimazole in the treatment of thyrotoxicosis. | fifteen patients with thyrotoxicosis were treated with low dose sustained release lithium carbonate 400 mg, combined with carbimazole 40 mg daily, and the therapeutic response was followed over a two week period. this response was compared with that obtained in a similar group of patient treated with carbimazole alone. li-carbimazole treatment brought about a fall in the mean total serum t4 of 57.4% compared with a drop of 32.8% in patients treated with carbimazole alone. the mean serum t3 fell ... | 1978 | 86350 |
| the role of termination factor rho in the development of bacteriophage t4 [proceedings]. | 1978 | 84604 | |
| studies on the mechanism of goitrogenic action of diphenylthiohydantoin. | diphenylthiohydantoin (dpth) is a potent goitrogenic compound and produces goiters in rats. like methimazole, dpth depresses plasma t4 and t3 concentrations and elevates plasma t4 and t3 concentrations and elevates plasma tsh concentration. unlike methimazole, however, dpth does not suppress thyroidal radioiodine uptake and thyroid hormone synthesis, although the monoiodotyrosine to diiodotyrosine ration is elevated by dpth. dpth does not inhibit thyroidal radioiodine release or augment the degr ... | 1978 | 84751 |
| structural changes during the transformation of bacteriophage t4 polyheads: characterization of the initial and final states by freeze-drying and shadowing fab-fragment-labelled preparations. | 1978 | 84876 | |
| the effects of thyroxine and climatic factors on colostral gammaglobulin absorption in newborn calves. | observations of 68 friesian and holstein x friesian calves in a single herd with low neonatal mortality gave the following results: --the calves which will suffer from diarrhoea but survive were in a hyperthyroid state (high levels of hormonal iodine, t3 and free thyroxine index) compared with the healthy animals. --the concentration of plasma globulins, after colostrum intake was lower in diarrhoeic subjects calves than in the healthy ones. --for the whole group of animals, plasma hormonal iodi ... | 1978 | 85426 |
| thyroid function in healthy premature infants. | thyroid function was studied in healthy premature and term infants between 12 hours and 3 months of age. t4 and ft4i followed parallel courses in both groups; during the first 45 days, however, the values were significantly lower in premature infants under 34 weeks' ega than in term infants (p less than 0.001). the post-delivery peak in tsh concentration (mean +/- sd) was 71.8 +/- 19.2 microunits/ml in the premature infants. in five premature infants, injection of trh elicited a tsh increment of ... | 1978 | 96241 |
| [comparison between t4 (c) and t4 (d)]. | 1978 | 96624 | |
| vitamin a and thyroxine carrier proteins in chicken plasma: steady-state control of the plasma level of free retinol-binding protein and free thyroxine. | 1. the binding parameters of prealbumin-2 with retinol-binding protein and thyroxine (t4) revealed the existence of distinct and multiple sites for both retinol-binding protein and t4. 2. from the analysis of binding parameters of retinol-binding protein with prealbumin-2 it is clear that under steady-state conditions about 99% of the holo-retinol-binding protein remains bound to prealbumin-2. 3. equilibrium dialysis studies on binding properties of thyroid hormones with prealbumin-2 revealed th ... | 1978 | 96868 |
| pituitary responsiveness to lhrh and trh in adolescent girls. | puberty is characterized by a progressive maturation of the hypothalamus-pituitary gonadal axis which, in girls results in menarche. the first menstrual cycles are usually irregular and anovulatory, and the subtle positive and negative regulation of sex steroids on the hypothalamus-pituitary axis has probably not reached adult maturity. an investigation has been carried out in 99 normal adolescent girls, divided into 3 groups: 1-2, 3-4 and 5 years after menarche, by measuring basal hormonal valu ... | 1978 | 96896 |
| [binding of 3,3',5'-triiodo-l-thyronine (rt3) to human serum proteins]. | the rt3-binding and human serum proteins was directly studied with tracer doses of radioactive rt3. polyacrylamide gel electrophoresis showed 125i-rt3 added to human serum was distributed among two proteins: albumin (carrying 57% of tracer rt3) and tbpa )22%). no binding was observed to tbg, protein binding t4. | 1978 | 96994 |
| a low t3 syndrome in diabetic ketoacidosis. | the pituitary-thyroid axis was investigated in nineteen euthyroid patients with severe diabetic ketoacidosis. a 'low t3 syndrome' was found, with the following characteristics: lowered serum concentrations of triiodothyronine (t3), increased reverse triiodothyronine (rt3), slightly low thyroxine (t4), normal thyrotrophin (tsh), slightly increased triiodothyronine uptake (rt3u) values, and a blunted tsh response to thyrotrophin-releasing hormone (trh). these disturbances in thyroid-function tests ... | 1978 | 97034 |
| thyroid function in children with growth hormone deficiency, either idiopathic or caused by diseases of the central nervous system. | thyroid function was assessed in thirty two patients with growth hormone deficiency (ghd) by clinical examination and by measurement of t4-levels, free t4-indices, basal tsh values and tsh responses to trh (100 mu/m2). sixteen patients (50%) were hypothyroid. in thirteen patients, the endocrine disorders were considered to be of hypothalamic origin. ten of them showed prolonged responses to trh and in the other three the responses were exaggerated. in three patients hypothyroidism was due to a p ... | 1978 | 97084 |
| the use of intramuscularly administered methyl-trh to evaluate the pituitary-thyroid axis. | the present study was carried out to evaluate the effectiveness of intramuscular administration of methyl-trh, a potent analogue of thyrotropin-releasing hormone, for assessing pituitary reserve of tsh and prolactin and for distinguishing euthyroid, hypothyroid and hyperthyroid individuals. serum samples were taken for 24 hours after intramuscular injection of methyl-trh, 200 microgram, in 19 euthyroid subjects, 9 hypothyroid men and 9 hyperthyroid men. the mean serum prolactin and tsh concentra ... | 1978 | 97198 |
| quantitative measurement of phagocytosis of neisseria gonorrhoeae by mouse peritoneal macrophages. | the simultaneous labeling of gonococci with [6-3h]uracil and of mouse peritoneal macrophages with l-[u-14c]leucine permits a quantitative assessment of the association of gonococci with macrophages under various experimental conditions. colony-type t1 (piliated) gonococci associated more than t4 (nonpiliated) organisms at 4 degrees c, but at 37 degrees c the association of t4 gonococci with macrophages exceeded that for the t1 organisms. the association of t1 gonococci with macrophages could be ... | 1978 | 97235 |
| divalent cation mobility throughout exponential growth and sporulation of bacillus megaterium. | each of the five elements considered was taken up by bacillus megaterium during exponential growth. initial mg and mn uptake was rapid and ended by mid-log. for ca, fe, and zn, uptake continued throughout exponential growth. elements were released from the cells immediately following initial uptake. for mn, egression continued to t2, with release of 36% of total accumulated. secondary uptake followed immediately and continued through stage v. magnesium egression continued to t1 with release of 3 ... | 1978 | 97497 |
| thyrotrophin-releasing hormone (trh) stimulation test in manic-depressive illness. | the thyrotrophin (tsh) response to thyrotrophin-releasing hormone (trh 200 microgram intravenously was studied in 19 patients with unipolar depression, 12 with bipolar depression, 14 with mania, and 5 with mixed manic-depressive illness. the tsh responses were decreased in all of these affective disorders compared to those found in 10 patients with reactive depression, 5 with reactive paranoid psychosis, 14 with neurotic depression, and 60 controls. the decrease of the tsh response in manics cou ... | 1978 | 98129 |
| effect of surgical stress on serum thyroid hormones in hyperthyroidism. | the effect of elective non-thyroidal surgery on serum total and free triiodothyronine (t3), reverse t3 and thyroxine (t4) has been studied in one patient with mild, untreated typical hyperthyroidism, one with mild t3 toxicosis and in four euthyroid patients. the high t3 level of typical hyperthyroidism became normal post-operatively, decreasing to 47% of the mean pre-operative level 24 hours after surgery, while total reverse t3 doubled. in euthyroid subjects t3 decreased to 57 +/- 6 (sem)% of t ... | 1978 | 98141 |
| effect of starvation on hypothalamic-pituitary-thyroid function in the rat. | total starvation in the rat for 2 days did not alter the hypothalamic content of thyrotropin-releasing hormone (trh), but did decrease both pituitary tsh content and serum tsh concentration. five days starvation resulted in a significant decrease in serum tsh and a slightly enhanced serum tsh response to exogenous trh, suggesting that the pituitary retains its sensitivity to trh. fasting for 5 days resulted in a decreased 1 and 4th, but an increased 24th thyroid 131i uptake. other starvation-ind ... | 1978 | 98684 |
| transfection with replicating dna from the temperate bacillus bacteriophage phi 105 and with t4-ligase treated phi105 dna: the importance in transfection of being longer than genome-length. | replicating phage dna extracted from bacillus subtilis infected with phage phi 105 has a higher activity in transfection than mature dna. by heteroduplex analysis it was shown that this dna contains concatemeric molecules. concatemers, constructed in vitro by treatment of mature dna with t4-ligase also have an increased activity in transfection. dna showing an increased activity in transfection does not have a requirement for more than one molecule per transfection event as is typically found fo ... | 1978 | 98703 |
| thyrotropin and prolactin secretory patterns during 24-hours infusion of thyrotropin-releasing hormone in calves. | plasma levels of thyrotropin (tsh), prolactin (prl), growth hormone (gh), thyroxine (t4), and triiodothyronine (t3) were measured in response to continuous 24-h infusion of synthetic thyrotropin-releasing hormone (trh) in normal and surgically thyroidectomized (thyx) calves in a series of 2 experiments. in the 1st experiment, the low dose of trh (0.077 microgram/min) had no effect on any hormone levels measured. plasma tsh concentration increased significantly (p less than 0.05) in response to t ... | 1978 | 98724 |
| use of t4 rna ligase to construct model substrates for a ribosomal rna maturation endonuclease. | rnase m5 of bacillus subtilis specifically cleaves a 179-nucleotide precursor 5s rrna to yield mature 5s rrna (116 nucleotides) and two fragments derived from the termini. possible recognition elements for rnase m5 within the precursor structure include nucleotide sequences arranged with 2-fold rotational and translational symmetry about the substrate bonds. we have used bacteriophage t4 rna ligase to construct, from synthetic oligonucleotides and mature or precursor 5s rrna fragments, test subs ... | 1978 | 98766 |
| [hormonal control of thyroxine-binding globulin synthesis and metabolism (author's transl)]. | serum thyroxine-binding globulin (tbg), the major plasma transport protein for thyroid hormones in man, was shown to be altered under the influence of estrogen and in hypothyroidism. in order to study these alterations, we used an animal model. synthesis of tbg was demonstrated in hepatocytes isolated from adult rhesus monkeys, and in a monkey hepatocarcinoma continuous cell culture line (nclp-6-e). when the hepatocytes were obtained from monkeys pretreated with beta-estradiol (e2), a specific 2 ... | 1978 | 99075 |
| [thyroid function in protein-caloric malnutrition in infants (author's transl)]. | iodine kinetics and thyroid function were investigated in 68 cases of protein-caloric malnutrition (senegales children). this nutritional state induces an acute and severe alteration of thyroid function, as indicated by the reduced iodine uptake and clearance, a 50% decrease of hormonal secretion rate, and the low levels of total and free t4. t3 concentration is also very low: this may be partly due to a defective conversion of t4 to t3. despite this state of primary hypothyroidism, no hypersecr ... | 1978 | 99076 |
| [tsh-response to trh in active coeliac disease in infants (author's transl)]. | in 11 infants of 3-19 months of age with active gluten-induced enteropathy, an exaggerated and sustained response of plasma tsh to trh was observed as compared to controls. in these same patients, there was a decrease in total and free t4 and t3 concentrations. all these values were statistically different from controls. | 1978 | 99077 |
| differences in susceptibilities of virulent strains and avirulent strains of neisseria gonorrhoeae to antimicrobial agents. | virulent cells (t1 colony type) and avirulent cells (t4 colony type) of neisseria gonorrhoeae were grown in a defined liquid medium in the presence of different antimicrobial agents. bacteria of t1 colony type were found to be more resistant than bacteria of t4 colony type to the inhibitory effects of specific concentrations of ampicillin (0.50 mug/ml) and penicillin (0.01 mug/ml). bacteria of t4 colony type, however, were found to be more resistant to the effects of chloramphenicol (0.40 mug/ml ... | 1978 | 99084 |
| spore coat protein synthesis in cell-free systems from sporulating cells of bacillus subtilis. | cell-free systems for protein synthesis were prepared from bacillus subtilis 168 cells at several stages of sporulation. immunological methods were used to determine whether spore coat protein could be synthesized in the cell-free systems prepared from sporulating cells. spore coat protein synthesis first occurred in extracts from stage t2 cells. the proportion of spore coat protein to total proteins synthesized in the cell-free systems was 2.4 and 3.9% at stages t2 and t4, respectively. the sod ... | 1978 | 99441 |
| preparation of glycopeptides and oligosaccharides from thyroxine-binding globulin. | over 99% of thyroxine (t4), the major form of thyroid hormone in plasma, is bound to the plasma glycoprotein thyroxine-binding globulin (tbg). the carbohydrate composition of tbg (14.6% by weight) consists of mannose, galactose, n-acetylglucosamine, and n-acetylneuraminic acid in the molar ratios of 11:9:16:10 per mol of glycoprotein. no fucose or n-acetylgalactosamine were detected. amino acid analyses were performed. glycopeptides, prepared by exhaustive pronase treatment of the glycoprotein, ... | 1978 | 99447 |
| piliation and colonial morphology among laboratory strains of meningococci. | colonial morphology and piliation were studied on twelve strains from various serogroups of neisseria meningitidis. six different colony types (m1 to m6) were identified. most strains elaborated only an m1 colonial type, which is similar to gonococcus t4. several combinations of piliation and colonial morphology were observed: (i) colonial variation in which neither parent nor variant were piliated; (ii) colonial variation involving piliated and nonpiliated cells; (iii) dissociation of piliated ... | 1978 | 99453 |
| regulation of tsh secretion in rats chronically exposed to heat (34 degrees c). | previous studies have shown that in heat exposed rats, a decreased plasma t4 concentration was associated with a normal biologically active tsh concentration. this study was designed to clarify this apparent discrepancy in the regulation of tsh secretion. in experimental rats (34 degrees c for 25 days) and controls (25 degrees c), plasma total t4 was 3.2 vs. 5.7 x 10(-8) mol/l. (p less than 0.01), plasma total t3: 2.4 vs. 5.7 x 10(-10)mol/l. (p less 0.01) and plasma tsh: bioassay 0.34 vs 0.29 mu ... | 1978 | 99725 |
| genome-linked protein associated with the 5' termini of bacteriophage phi29 dna. | a dna-protein complex was isolated from bacillus subtilis bacteriophage phi29 by sucrose gradient sedimentation or gel filtration in the presence of agents known to break noncovalent bonds. a 28,000-dalton protein was released from this complex by subsequent hydrolysis of the dna. the dna-protein complex was examined for its susceptibility to enzymes which act upon the 5' and 3' termini of dna molecules. it was susceptible to exonucleolytic degradation from the 3' termini by exonuclease iii but ... | 1978 | 100608 |
| thyroxine-binding globulin deficiency: innocent cause of low serum thyroxine (t4) levels. | 1978 | 100751 | |
| reverse triiodothyronine, thyroid hormone, and thyrotrophin concentrations in placental cord blood. | reverse triiodothyronine (rt3), triiodothyronine (t3), thyroxine (t4), thyroxine binding globulin (tbg), and thyrotrophin (tsh) were measured in sera from placental cord blood in an unselected series of 272 deliveries. in this series the concentrations of rt3 (mean 3.33 nmol/l, 95% confidence limits 1.6--7.0 nmol/l), were log normally distributed and did not overlap the adult normal range (0.11--0.44 nmol/l). there were no correlations between the cord blood concentrations of rt3, t3, t4, and ts ... | 1978 | 101154 |
| the quaternary structure of the sheaths of defective phages similar to pbs x. | the contractile sheaths of five defective, pbs x-like bacteriophages from bacillus subtilis and b. licheniformis were investigated by electron microscopy, dodecylsulphate gel electrophoresis and immunodiffusion. electron microscope images of the extended and contracted sheaths were of similar appearance, although their lengths were different. the surface lattices of both the extended and the contracted sheaths were determined by optical diffraction. this showed that the quaternary structure of t ... | 1978 | 101370 |
| [erythrocyte carbonic anhydrases in patients with hyperthyroidism (author's transl)]. | human erythrocyte carbonic anhydrase b (ca-b) and c (ca-c) were measured by a specific and immunological method and erythrocyte 2,3-diphosphoglycerate (2,3-dpg) concentrations were measured using a kinetical method. the levels of ca-b and ca-c were determined in normal subjects, patients with hyperthyroidism and patients with hypothyroidism, using the method of single radial immunodiffusion. a decrease of ca-b levels and an elevation of 2,3-dpg concentrations were noted in hyperthyroidism. the c ... | 1978 | 101433 |
| effects of iron and culture filtrates on killing of neisseria gonorrhoeae by normal human serum. | neisseria gonorrhoeae gc9, both colony types t2 and t4, were killed by normal human serum, although populations of colony type t4 were more susceptible. ferric ammonium citrate prevented the killing of populations of both t2 and t4 colony types. other iron compounds tested showed no protective effect, nor did ammonium citrate or the divalent cations magnesium or calcium. a filtrate from cultures of an n. gonorrhoeae strain grown in a liquid defined medium showed a similar protective effect in th ... | 1978 | 101468 |
| [preliminary results of a new radioimmunoassay for thyroxine binding globulin (t.b.g.) (author's transl)]. | a radioimmunoassay for the accurate measurement of t.b.g., developed by crouzat-reynes, was used to perform t.b.g. concentration in sera of euthyroid subjects in different clinical situations, in hypothyroid and hyperthyroid patients. in normal control, the t.b.g. concentration was not different from men and women, from young and old subjects (m = 21,1; sigma = 3,9). on the other hand, in women either pregnant (m = 51,2; sigma = 18,1) or receiving oral contraception (m = 30,1; sigma = 5,7), the ... | 1978 | 101971 |
| clinical value of total t4 and t3 determinations in patients with suspect hyperthyroidism before and after correction for binding proteins. | 1978 | 102119 | |
| normal prolactin response following thyrotrophin releasing hormone in patients with autonomously functioning euthyroid multinodular goitre. | twelve female patients (mean age 60 years, range 41--74) with euthyroid multinodular goitre and a flat trh test (median delta tsh 0.9 muiu/ml, range 0--3.5) had normal prolactin responses to trh (median data prolactin 48 ng/ml, range 6--115). the results are comparable with those in euthyroid patients receiving full substitution doses of thyroid hormone without increasing t3 and/or t4 levels beyond the normal range. | 1978 | 102470 |
| [clinical evaluation of thyroid functions in chronic hemodialysis patients (author's transl)]. | in order to obtain more precise information on thyroid functions in renal failure, attempts were made to analyze the hypothalamo-hypophyseal axis in the regulation of thyroid function. trh levels and other thyroidal function tests were carried out on sera and urine from patients with renal failure and thyroid diseases. analysis of trh in serum and urine was performed by mass fragmentography using a gc-ms combined method. fifteen out of 28 patients had enlarged thyroid glands, goiter in high prev ... | 1978 | 102540 |
| failure of alpha-methyltyrosine to inhibit peripheral triiodothyronine formation. | to determine if the adrenergic nervous system, and specifically tyrosine hydroxylase, plays a role in the extrathyroidal conversion of t4 to t3, normal male volunteers were treated with t4 and subsequently with t4 and alpha-methyl-p-tyrosine (alpha-mpt), an inhibitor of tyrosine hydroxylase, for 2 weeks. the mean serum t4 and t3 concentrations increased during t4 administration and remained at the same levels during combined t4 and alpha-mpt administration. urinary vanillylmandelic acid excretio ... | 1978 | 45464 |
| regulation of thyroid hormone metabolism in rat liver fractions. | the nature of the conversion of thyroxine (t4) to triiodothyronine (t3) and reverse triiodothyronine (rt3) was investigated in rat liver homogenate and microsomes. a 6-fold rise of t3 and 2.5-fold rise of rt3 levels determined by specific radioimmunoassays was observed over 6 h after the addition of t4. an enzymic process is suggested that converts t4 to t3 and rt3. for t3 the optimal ph is 6 and for rt3, 9.5. the converting activity for both t3 and rt3 is temperature dependent and can be suppre ... | 1978 | 23865 |
| how thyroid disease presents in the elderly. | some of the symptoms and signs of hypothyroidism and hyperthyroidism in elderly patients may be mistakenly attributed to "old age." weight loss, muscle weakness, tremor, angina, congestive heart failure--all signs of hyperthyroidism--are also concomitants of aging. fatigue, sluggishness, withdrawal behavior, senile atrophic skin changes--all signs of hypothroidism--are also a part of the normal aging process. although screening elderly people for thyroid disease is economically unsound, the phys ... | 1978 | 24576 |
| apropos of complications following the use of methylmethacrylate. possible prevention by betamethasone. | the aim of this study was to determine whether the prior injection of betamethasone was capable of preventing blood pressure changes and the fall in arterial po2 when following the fixation of total hip protheses with methyl metacrylate. it involved 54 patients in whom systolic, diastolic and mean blood pressure (bp), arterial po2, pco2 and heart rate were noted at different times: t1, 15 minutes after the beginning of the operation; t2 and t3, one minute and five minutes after application of th ... | 1978 | 28053 |
| effect of starvation, nutriment replacement, and hypothyroidism on in vitro hepatic t4 to t3 conversion in the rat. | to evaluate the effect of starvation, oral and i.v. nutriments, and hypothyroidism on the peripheral conversion of thyroxine (t4) to 3,3', 5-triiodothyronine (t3) in the rat and mouse, an in vitro system for assessing t4 conversion to t3 by fresh liver homogenates was used. a 2-day starvation in the rat reduced hepatic t3 generation from t4 by 47% +/- 3.5% (mean +/- se) in six separate experiments and also impaired the metabolism of 125i-r-t3. administration of carbohydrate (cho) and amino acids ... | 1978 | 30020 |
| conversion of t3 and rt3 to 3,3'-t2: ph dependency. | in the extrathyroidal deiodination of t4 the importance of t3 and rt3 for the peripheral action of thyroid hormones is well documented. with the development of a specific radioimmunoassay for 3,3'-t2, a deiodination product of both t3 and rt3, we were able to characterize these subsequent enzymatic reactions as well as the degradation of 3,3'-t2 in rat liver homogenate. it was found that the reaction t3 leads to 3,3'-t2 is slow compared to the conversion of t4 to t3. the ph activity profile show ... | 1978 | 31249 |
| late components of the visual evoked potential to search in short-term memory. | the present paper investigated the changes in the morphology of the vep as a function of the amount of search in short-term memory. the task required that the subject responds with a "yes" or "no", depending on whether a test digit has been part of a set of digits he had just seen. six sizes of sets were used, 1, 3, 5, 7, 9 and 11. eeg was recorded from c3, c4, t3, t4, cz, pz and oz, and sampled every 4 msec to obtain vep to the test digit. two late components were found to increase in latency w ... | 1978 | 75088 |
| specificity of helper t cells for different antigens. | balb/c nude mice have been injected with 10(6) congenic thymus cells, a number which allows some, but not all mice to respond to any particular t-dependent antigen. these mice have been tested for their ability to respond to three bacteriophages, t4, t7 and phix, sheep and horse erythrocytes, and alloantigens of c3h and c57bl/6 mice. the number of mice able to respond to each of these antigens was of the same order of magnitude. sheep and horse erythrocytes showed cross-reactivity at the t cell ... | 1978 | 76566 |
| thyroid function in patients undergoing maintenance hemodialysis: unexplained low serum thyroxine concentration. | thyroid function was studied in 55 patients undergoing maintenance hemodialysis who were all judged to be clinically euthyroid. the dialysis patients, in comparison to normal control subjects, had significantly lower mean values for serum t4 (4.0 +/- 1.4 [sd] microgram/dl versus 7.9 +/- 1.5 microgram/dl, p less than 0.001), t3 (118 +/- 31 ng/dl versus 147 +/- 28 ng/dl, p less than 0.001), free t4 measured by equilibrium dialysis (1.22 +/- 0.38 ng/dl versus 2.15 +/- 0.67 ng/dl, p less than 0.001) ... | 1978 | 78430 |
| closer correlation between serum triiodothyronine and basal metabolic rate during antithyroid drug treatment in patients with graves' disease. | the correlations between serum triidothyronine (t3), thyroxine (t4), 131i-triiodothyronine resin sponge uptake (rt3u) or free thyroxine index (t7) and the basal metabolic rate (bmr) during antithyroid drug treatment in 86 patients with graves' disease were investigated. although serum t3, t4, rt3u and t7 during therapy with mmi showed significant positive correlations with bmr, the coefficient of correlation (r = 0.6088, p less than 0.001) between t3 and bmr was the highest of all. while the nor ... | 1978 | 78844 |
| thyroid hormones homeostasis and tsh in autonomic thyroid nodule. | thirty patients with autonomic thyroid nodules were studied. thyroid scintigram, iodine uptake at 2 and 24 hrs, pbi, total thyroxine, serum t3(ria), basal tsh and 30 minutes after trh administration were performed. a lack of concordance was found between the clinical signs and the laboratory data. according to the data obtained the patients were grouped into 3 categories: having 1) autonomic thyroid nodules with normal pbi, t4t, t3 values and absent or diminished tsh response to trh; 2) autonomi ... | 1978 | 79214 |
| [triiodothyronine, reverse-triiodothyronine, thyroxine, resin-triiodothyronine-uptake and protein bound jodide in the fluid of thyroid cysts (author's transl)]. | t3, rt3, t4, pbi and the saturation of t3-t4-binding proteins in yellow and brown cyst fluids of nontoxic goiters differ from the values in sera. in the brown cyst fluids, resulting from a hemorrhage, t3, rt3, t4, pbi and t3 u are significantly higher than in sera and no correlation could be found with the values in sera. in the yellow cyst fluids t3 and t3 u are significantly higher then in sera, t4 is lower, pbi and rt3 do not differ from the values in sera. only t3 and rt3 are not correlated. ... | 1978 | 79671 |
| differentiation of thyrotoxicosis induced by thyroid destruction from graves' disease. | thyroid function was tested in untreated patients with graves' disease or thyrotoxic subacute thyroiditis, and in patients with autoimmune thyroiditis who showed postpartum or spontaneous transient thyrotoxicosis. the serum triiodothyronine/thyroxine ratio (t3/t4) was greater than 20 ng/microgram in graves' disease but less than 20 in all patients with subacute thyroiditis and 9 of 11 patients with autoimmune thyroiditis. thus, like radioactive iodine uptake, the serum t3/t4 ratio is useful for ... | 1978 | 79711 |
| [maintenance of anti-streptococcal activity of haptoglobins after addition of hemoglobin]. | the antibody-like activity of haptoglobin types hp 2-2 and hp 2-1 for streptococci having the t4 antigen is not reduced by saturation with hemoglobin. | 1978 | 80363 |
| [serum levels of t3 and t4 in hyperthyroidism during the administration of antithyroid drugs (author's transl)]. | 1978 | 80813 | |
| anti-thyroxine and anti-triiodothyronine antibodies in three cases of hashimotos thyroiditis. | antibodies against thyroxine (t4) and/or triiodothyronine (t3) were detected in 3 patients with hashimoto's thyroiditis. one of the patients had both anti-t4 and anti-t3 antibodies and the other 2 patients had only anti-t3 antibody. serum t4 or t3 antibodies and the other 2 patients had only anti-t3 antibody. serum t4 or t3 values measured by the single antibody radioimmunoassay (ria), were low or nil in these patients. one patient was mildly hypothyroid. the other 2 patients were clinically eut ... | 1978 | 81582 |
| indirect methods of assessing thyroid function. protein-bound iodine and thyroxine by column chromatography, a 1976 cap survey. | an assessment of the infrequently performed protein-bound iodine determinations (pbi) and thyroxine (t4) determinations by column chromatography is presented after analysis of data contributed by participants in the 1976 college of american pathologists chemistry survey programs. the two technics yield comparable mean concentrations, but there is considerable interlaboratory variance within method groups, especially among laboratories performing column chromatographic t4 iodine assays. | 1978 | 81610 |
| t3/t4 ratio in thyroid disease. | 1978 | 82076 | |
| thyroid and obesity: survey of some function tests in a large obese population. | tests of thyroid function in 493 obese patients were compared with thyroid function in 3076 non-obese patients. no differences in 131i uptake by the thyroid were observed at 6 h or 24 h; the frequency distribution was gaussian or normal in both populations; the frequencies of normal, high or low t3 and t4 values in the two populations were likewise comparable. further, no correlation was found in the obese subjects between 131i uptake (6 h and 24 h), t3, t4 and overweight; on the other hand, the ... | 1978 | 82549 |
| changes in circulating iodothyronines in euthyroid and hyperthyroid subjects given ipodate (oragrafin), an agent for oral cholecystography. | a dose (3 g) of sodium ipodate used routinely in oral cholecystography caused a fall in serum 3,5,3'-triiodothyronine and a rise in serum 3,3',5'-triiodothyronine in three patients taking thyroxine (t4), four euthyroid subjects,and four hyperthyroid patients. serum t4 fell in patients with hperthyroidism, whereas it rose in the other two groups. sodium ipodate appears to alter peripheral t4 metabolism and, in addition, produces thyroid-inhibiting effects in hyperthyroidism. | 1978 | 582597 |
| pituitary stalk-section and some of its effects on endocrine function in the fetal lamb. | a detailed description is given of a method to section the pituitary stalk of the fetal lamb after 105 days gestational age. the approach to the stalk is made through a window in the frontal bone. in order to prevent regeneration of the hypothalamo-pituitary connections a silicone plate is introduced through the probe used to fracture the stalk. the surgical outcome and viability of 11 pituitary stalk sectioned fetuses is described over periods of up to 23 days. the presence of pituitary infarct ... | 1978 | 250110 |
| rotary replication for freeze-etching. | rotary replication has been adapted to freeze-etching and evaluated using t4 polyheads, erythrocyte ghosts, and chloroplast membranes. conventional electron microscopy, electron diffraction, and optical diffraction and filtering indicate that platinum-carbon rotary replication renders radially symmetrical contrast and 25 a resolution to freeze-etched specimens so as to clarify subunit structure not normally evident in unidirectional shadow replicas. | 1977 | 830655 |
| reassessment of the daily dose of oral thyroxine for replacement therapy in hypothyroid children. | the optimal daily requirement of sodium l-thyroxine for replacement therapy of hypothyroidism was evaluated in 11 hypothyroid children ranging from one to 14 years of age. the "optimal" dose of l-t4, defined as the minimal daily dose necessary to suppress the serum concentration of tsh to normal, was determined in each patient and individual growth rates were assessed for periods up to 12 months during the time this dose was being administered. the mean "optimal" dose of l-t4 was 3.78 +/- 0.6 mu ... | 1977 | 830925 |
| effects of thyroid dysfunction on the development of the rat cerebellum, with special reference to cell death within the internal granular layer. | the increased cell death within the internal granular layer of the cerebellar cortex, previously demonstrated by other investigators in 12-day-old rats treated with propylthiouracil, was found again in 10-, 14- and 21-day-old similarly treated young rats. in thyroid-deficient as well as in normal animals, cell death was maximal at 10 days. in hypothyroid rats, the greatest difference with the normal animals was at 14 days, when there was an increase by a factor of 20 of the number of dying cells ... | 1977 | 832138 |
| acute and chronic responses to iodine deficiency in rats. | various indices of thyroid function were measured in rats at early (2 to 26 days) and at late (up to 55 weeks) intervals after the onset of an iodine deficient diet (lid). control groups received the same diet with iodine-supplemented drinking water. the measurements included: thyroid total 127i concentration, thyroid weight, [131i] mit/[131i]dit and [131i]t3/[131i]t4 after a labeling period of 18--24 h, serum t4, serum t3, and serum tsh. in the acute experiments serum t4 was significantly decre ... | 1977 | 832626 |
| preferential renal excretion of iodide derived from thyroxine and triiodothyronine deiodination in man. | tracer doses of 131i- (carrier free), 131i-t3 and 131-t4 were administered po to 19 healthy male volunteers at intervals 2 to 8 weeks to study whether or not part of the iodide generated in the kidney from t3 and t4 deiodination may enter the renal tubular lumen and be excreted in the urine without entering the blood stream. u(urine)/t(thyroid) ratios of the radioactivity from these materials were employed as the index of the comparison. u/t ratios were severalfold higher 24 h after 131i-t3 or 1 ... | 1977 | 833251 |