Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| [fluorescent thyroid scanning and intrathyroidal iodine quantification: study in 140 patients (author's transl)]. | the system consists of twenty individual sorces of one ci of 241am and a high resolution lithium drifted silicon detector. a dual channel analyser permits to measure intrathyroidal stable iodine. the scan requires only 13 minutes and can be made with a very low radiation dose (less than 10 mrads). it provides good quality images and remains available in cases of flooded iodine pools or iodine induced thyrotoxicosis. it is of great interest to follow up subacute thyroiditis and to diagnose autono ... | 1978 | 662595 |
| [determination of serum thyroxine using ria-gnost t4 (author's transl)]. | 1978 | 663324 | |
| myxedema coma and normal serum thyroxine. | a 76-year-old man who developed the clinical syndrome of myxedema coma was found to have a normal serum thyroxine concentration. further investigation revealed the presence of a low serum t3 level before and after sodium levothyroxine therapy when the serum t4 value was in the hyperthyroid range. in addition, he demonstrated an inability to release tsh after intravenous administration of trh and was found to have an enlarged sella turcica. a partial defect in peripheral conversion of t4 to t3 is ... | 1978 | 663737 |
| antigenic gene products of bacteriophage t4 baseplates. | 1978 | 664235 | |
| [technical realization of the t3 and t4 tests as well as of the triiodothyronine radioimmunoassay]. | 1978 | 664812 | |
| thyroid disease and function in breast cancer patients and non-hospitalized controls evaluated by determination of tsh, t3, rt3 and t4 levels in serum. | investigations concerning a possible influence of thyroid disease and function on the risk for breast cancer have given contradictory results--although a slight hypothyroidism was repeatedly suggested and supported by increased thyrotropin concentrations and exaggerated trh-responses. the selection of proper controls was stressed and in this study 179 consecutively diagnosed breast cancer patients were compared with 179 age-matched controls chosen from a computerized population register. the pre ... | 1978 | 665106 |
| disturbed circadian variation of serum thyrotropin in patients with endogenous depression. | the relationship between the degree of depression and the circadian variation of serum tsh, t3 and t4 was investigated in 19 endogenously depressed patients. the difference between the hormone concentrations at 2 p.m. and at 12 p.m. was taken as an estimate of the magnitude of circadian variation. it was found that the circadian variation in serum tsh was inversely related to the degree of endogenous depression. this was mainly due to a diminution or absence of the night increase of tsh in sever ... | 1978 | 665284 |
| enzymatic oligoribonucleotide synthesis with t4 rna ligase. | the substrate specificity of t4 rna ligase has been examined to determine whether the intermolecular reaction is sufficiently general to realize its potential in the enzymatic synthesis of oligoribonucleotides of defined sequence. reactions between a variety of acceptor molecules with 3'- and 5'-bydroxyl groups and donor molecules with 3'- and 5'-phosphates indicate that the minimal substrates are a trinucleoside diphosphate acceptor and a nucleoside 3',5'-bisphosphate donor. increasing the chai ... | 1978 | 667012 |
| synthesis of modified nucleoside 3',5'-bisphosphates and their incorporation into oligoribonucleotides with t4 rna ligase. | a simple procedure is described to prepare nucleoside 3'(2'),5'-bisphosphates from the corresponding nucleosides with the use of pyrophosphoryl chloride. this method is rapid, gives nearly quantitative yields and, most importantly, can be used for a variety of nucleosides with base and sugar modifications. since 3',5'-bisphosphates are donors in the t4 rna ligase reaction, a single residue can be enzymatically attached to the 3' end of oligoribonucleotides. by these procedures, five different ri ... | 1978 | 667013 |
| a radioimmunoassay for 3,5-diiodothyronine. | a radioimmunoassay for the measurement of 3,5-diiodothyronine (3,5-t2) using a 3h-labelled derivative of 3,5-t2 as tracer has been developed. the cross-reactivity of the antiserum was relatively high for t3 (3.1%) and low for t4 (less than 0.0015%). 3,5-t2 serum concentrations measured after fractional enrichment of 3,5-t2 were near or below the detection limit of 0.1 nmol/l in ten normal subjects and 0.38 nmol/l in five hyperthyroid patients. 3,5-t2 was also detected in thyroid tissue. the seru ... | 1978 | 668156 |
| [experimental and clinical studies of seralute-t4 ria kit]. | 1978 | 668164 | |
| [studies of thyroxine radioimmunoassay with a solid phase method--konsul t4 ria kit]. | 1978 | 668168 | |
| thyroid function and polyamines. iii. changes in ornithine decarboxylase activity and polyamine contents in the rat thyroid during hyperplasia and involution. | changes in ornithine decarboxylase (odc) activity and in polyamine contents of the rat thyroid were studied under various experimental conditions. methylthiouracil (mtu) treatment produced several-fold increases in the thyroid odc activity and in the content of putrescine, spermidine and spermine within a week. while serum thyrotropin (tsh) levels increased gradually up to 3 weeks, the content of both putrescine and spermidine tended to reach a plateau after 2 weeks of the goitrogen treatment; s ... | 1978 | 668626 |
| effect of ethanol on the peripheral metabolism of thyroxine. | to determine the effect of ethanol on peripheral metabolism of t4, deiodinative clearance of t4 and serum concentration of t4, t3 and rt3 were measured in rats isotopically equilibrated with t4. ethanol 8 g/kg weight/day was given for 3 days to fasted rats and the results were compared with those normally fed or totally fasted animals. in fasted rats, deiodinative clearance of t4 and serum t4 and t3 concentration, and t3/t4 ratio, were decreased significantly, while serum rt3 concentration and s ... | 1978 | 668634 |
| decreased ratio of serum t3:rt3 in patients with hyperthyroidism. | in 14 hyperthyroid patient serum t4:rt3 ratio was significantly lower (399 +/- 20) than in the control subjects (572 +/- 20; p less than 0.001). a similar pattern was found for serum t3:rt3 ratio. in the hyperthyroid group the ratio was significantly lower (10.5 +/- 0.5) than in the control group (12.5 +/- 0.6; p less than 0.05). the data suggest that in hyperthyroidism the organism might shift conversion of t4 from biologically active t3 to poorly calorigenic rt3. it seems possible that the pro ... | 1978 | 668639 |
| transcription of bacteriophage t4 dna in vitro: selective initiation with dinucleotides. | the transcription products of phage t4 dna in vitro are separated on polyacrylamide gels. the influence of salt, polymerase, triphosphate concentration and glucosylation on the rna synthesis are shown. individual transcripts are initiated selectively with dinucleotides and a single triphosphate. this technique allows the prediction of the initiation sequences of several t4 transcripts. | 1978 | 668702 |
| behavioral effects of neonatal thyroid hormones and differential postweaning rearing in rats. | male and female rats (t rats) given an injection of 75 microgram tri-iodothyronine (t3) and 25 microgram thyroxine (t4) on day 3 after birth were raised under enriched (e) and impoverished (i) postweaning conditions. observations of their open-field behavior and days 63 and 112 revealed a higher rate of activity in t groups as compared to controls (c) as well as faster running times and more entries/min in hebb-williams maze testing on days 74-86, indicating behavioral hyperactivity in t rats. a ... | 1978 | 669060 |
| [effect of estrogen upon thyroid metabolism (author's transl)]. | during enhanced endogen estrogen production (pregnancy) as well as during exogen estrogen application a rise occurs in tbg concentration in serum, which seems to be dose related. simultaneously with the tbg there is an increase in total t4 and t3; the concentrations of the free t4 and t3 however decrease. towards the end of pregnancy aft4 is significantly decreased, compared to the controls, aft3 being in the lower normal range. the lower concentrations of the free hormones are also documented b ... | 1978 | 672766 |
| [blood level of thyroid hormones in surgical thyroid diseases. pre-,intra- and post-operative t3 and t4 levels]. | a pre-, intra- and post-operative determination of thyroid hormone in values in the peripheral and thyroid vein reflux blood of patients with thyroid disorders requiring surgery showed that the so-called intraoperative squeezing of the gland either does not place or is of little importance when delicate surgical movements are commenced. a low incidence of intraoperative arrhythmia was also noted. prevention of the latter is not indicated, since it is often dependent on surgical movements and/or ... | 1978 | 673215 |
| [fundamental study on t4 peg riapac kit (author's transl)]. | 1978 | 674710 | |
| the synthesis of 25-hydroxycholecalciferol-23,23,24,24-t4 of high specific activity. | catalytic tritium reduction of cholest-5-en-23-yne-3beta,25-diol diacetate (viii) gave cholest-5-ene-3 beta,25-diol diacetate-23,23,24,24-t4 (ix) having a specific activity of 92 ci/mmol. bromination, dehydrobromination and hydrolysis of the labelled material gave cholesta-5,7-diene-3beta,25-diol-23,23,24,24-t4 (xi) which was photolyzed to the previtamin and then thermally equilibrated to 25-hydroxycholecalciferol-23,23,24,24-t4 (i). | 1978 | 675737 |
| the role of irradiation in the management of head and neck cancer: analysis of results and causes of failure. | the records of patients with squamous cell carcinoma of the oral cavity, oropharynx, supraglottic and glottic larynx, whose primary lesion was treated with radiation therapy from 1964 through 1973, were reviewed. end points of the study are local control rate at the primary site, ultimate control with surgical salvage, and causes of failure. the local control rate at the primary site was 90% for t1 lesions, 80% for t2 lesions, and approximately 70% for selected t3 lesions. the control rates for ... | 1978 | 675861 |
| the effects of thyroid hormones on myelination in the developing rat brain. | rats radiothyroidectomized 1 day after birth received daily subcutaneous injections of 1 microgram/10 g body weight of thyroxine (t4) or an equimolar amount of triiodothyroacetic acid (t3ac) from day 6 through day 25. the number of myelinated axons, myelinated axon area, and area of the myelin sheath in the corpus striatum were investigated. hypothyroid neonates demonstrated a normal number of myelinated axons with a decrease in the area of these axons. t4 treatment resulted in an increased numb ... | 1978 | 678604 |
| 'low t3 syndrome' in patients chronically treated with an iodine-containing drug, amiodarone. | cardiac patients treated with the iodine-containing drug 'amiodarone' undergo a significant iodine overload which can last for months after the drug has been withdrawn. some patients develop hyperthyroidism and others hypothyroidism. in the hyper- or hypothyroid patients, the indices of thyroid function are modified as usually observed in these situations. in the patients remaining euthyroid while taking amiodarone or after its withdrawal, but still under its influence as shown by the iodine ove ... | 1978 | 679500 |
| hypothalamic-pituitary functions in patients with idiopathic pituitary dwarfism. further evidence for hypophysiotropic human deficiencies. | somatotropic, thyrotropic, gonadotropic and corticotropic functions in 10 patients with idiopathic hypopituitary dwarfism (ih) were investigated. the patients were divided into two groups: group i (5 patients) had normal plasma t4 levels, and group ii (5 patients) had t4 levels of less than 4.6 microgram/dl. in group i three cases had isolated growth hormone (gh) deficiency and two cases had gh and gonadotropin (gn) deficiencies; in group ii the 5 cases showed multiple anterior pituitary hormone ... | 1978 | 679952 |
| non-glucoregulatory hormones (t4, t3, rt3, tsh, testosterone) during physical exercise in juvenile type diabetics. | non-glucoregulatory hormones (t4, t3, rt3, tsh and testosterone) were studied by radioimmunoassay in juvenile-type diabetics in moderate control and in ketosis due to insulin withdrawal and in age matched "normals" during a mild prolonged exercise test. the basal serum hormone levels revealed the following findings: serum testosterone was markedly lower in diabetics than in normals ( 177 +/- 24 resp. 618 +/- 52 ng/dl). this is in contrast to other studies, but it may reflect decreased testicular ... | 1978 | 680627 |
| thyroid function in acute intermittent porphyria: a neurogenic cause of hyperthyroidism? | thyroid function was investigated in 17 patients with acute intermittent porphyria (aip). in 13 patients in remission and latent for the disease, thyroid function was normal. in contrast, transient hyperthyoridism with elevated total t4, t3 free t4 and t3, and fti levels occurred in one pregnant patient with severe attacks of aip, and similar, though less pronounced, alterations in thyroid function were found in three other symptomatic female patients. it is suggested that increased thyroidal sy ... | 1978 | 680630 |
| patterns of primary thyroid failure. | serum thyroxine(t4), triiodothyronine (t3) and thyroid-stimulating hormone (tsh) levels were measured in 170 patients with suspected hypothyroidism. only patients with elevated serum tsh levels indicative of some degree of primary thyroid failure were included in the study. they appeared to represent four distinct classes of thyroid failure: class 1 (19.5%) had normal t4 and normal t3; class 2 (8%) had low t4 and elevated t3; class 3 (37%) had low t4 and normal t3; and class 4 (35.5%) had low t4 ... | 1978 | 681161 |
| mutagenesis at a specific position in a dna sequence. | predefined changes in a known dna sequence were introduced by a general method. oligodeoxyribonucleotides complementary to positions 582 to 593 of the viral dna strand of the bacteriophage phix174 am3 mutant (pgtatcctacaaa), and to the wild type sequence in this region (pgtatcctacaaa), were synthesized and used as specific mutagens. each of these oligonucleotides was incorporated into a complete circular complementary strand when used as primer on a genetically heterologous viral strand template ... | 1978 | 681366 |
| the size of the bacteriophage t4 head in solution with comments about the dimension of virus particles as visualized by electron microscopy. | 1978 | 682194 | |
| assembly of bacteriophage t4 head-related strucutres. ii. in vitro assembly of prehead-like structures. | 1978 | 682197 | |
| inhibition of tsh-stimulated radioiodine turnover and release of t4 and t3 in vivo by somatostatin. | 1978 | 682991 | |
| late endocrine effects of administering monosodium glutamate to neonatal rats. | rats were injected with monosodium 1-glutamate (msg) daily for the 1st 5 days of life and allowed to mature. this is known to cause selective destruction of neurons in the retina and in the arcuate nucleus of the hypothalamus. the adult animals had a significant increase in body fat without an increase in weight, a marked reduction in pituitary, thyroid, adrenal, gonadal and prostate weights. pituitary, hypothalamic and serum thyrotropin (tsh) were significantly reduced in the males. serum growt ... | 1978 | 683472 |
| mitigation of cretinism by breast-feeding. | an athyrotic infant had hypothyroidism at 1 year of age. he had grown at an above-average velocity until age 10 months when breast-feeding was discontinued, yet his bone age remained that of a newborn. these observations suggested that breast-feeding had attenuated hypothyroidism by providing significant quantities of thyroid hormones in the milk. to test this hypothesis, thyroxine (t4), 3,5,3'-triiodothyronine (t3), and 3,3,5'-triodothyronine (reverse t3) were measured in breast milk samples co ... | 1978 | 683777 |
| [ring experiment for determining thyroid function: triidothyronine binding capacity (tbg), total thyroxine (t4), thyrotropin (htsh) and the effective thyroxine quotient (etr)]. | 1978 | 684188 | |
| the effect of propranolol on serum levels of t4, t3 and reverse-t3 in hyperthyroidism. | the effect of propranolol (40 mg t.d.s.) on the peripheral levels of t4, t3 and reverse-t3 was studied in 26 patients with hyperthyroidism. the compounds were measured by specific radioimmunoassay techniques. the levels were followed for five weeks and compared with the levels before treatment. the results show that propranolol had no significant effect on the peripheral levels of t4 despite a rapid amelioration of clinical symptoms. a significant reduction of t3 levels was obtained during the f ... | 1978 | 685727 |
| effects of thyroxine on protein turnover in rat skeletal muscle. | the effects of thyroxine (t4) on protein turnover in skeletal muscle were studied using normal, thyroidectomized (thyrex), and hypophysectomized (hypox) rats. thyrex rats had a depressed growth rate that was accompanied by 50% reductions in the level of rna and the rate of protein synthesis in gastrocnemius muscle, as determined in the perfused hemicorpus. protein synthetic efficiency (protein synthesis per unit rna) was decreased by 18%. daily treatment of thyrex rats with t4 at different dose ... | 1978 | 686169 |
| [amiodarone-induce "low t3-syndrome" (author's transl)]. | amiodarone induces in patients "low t3-syndrome" characterized by normal t4. t3 resin uptake and free t3, contrasting with low t3 and free t4 values, and enhanced concentration of r-t3. | 1978 | 686653 |
| [pathogenesis of endemic goiter: evidence of a dietary factor different from iodine deficiency (author's transl)]. | the role of cassava was investigated in particularly severe endemic goiter area (ubangi). dietary intake of cassava induces an increase of plasma thiocyanate concentration and an increase of urinary excretion of stable iodine. generalized iodine deficiency induces very high thyroid uptakes; the other parameters of thyroid function are more or less affected according to the dietary intake of thiocyanate. when thiocyanate intake is high an adaptation is obtained only at the expense of a drop of pl ... | 1978 | 686655 |
| [serum thyroid hormones in hyperthyroid patients treated with carbimazole (author's transl)]. | serum thyroxine (t4), triiodothyronine (t3) and thyrotropin (t.s.h.) were measured in 32 hyperthyroid patients treated with carbimazole. a discrepancy between serum t4 and t3 was present in 73 of 131 measurements: --normal t3 with increased t4 in 6 measurements; --increased t3 with normal t4 in 16 measurements: five times only there was a clinical hyperthyroidism; --normal t3 with decreased t4 in 49 measurements: three times only there was a clinical hypothyroidism. serum t.s.h. level was increa ... | 1978 | 686661 |
| prognostic importance of the tumor-free laryngectomy specimen. | in a review of 500 consecutive laryngectomies, 36 specimens were found with no tumor. all patients had received radiation treatment preoperatively. patients with small primary tumors and no tumor evident in microscopically examined lymph nodes had excellent long-term survival. those patients with extensive (t4) primary tumors or with tumor found microscopically in their lymph nodes had poor survival statistics. this information reconfirms the known limitations of radiation and surgery in the cas ... | 1978 | 687216 |
| t4 polynucleotide ligase catalyzed joining on triple-stranded nucleic acids. | dt1o will form triple-stranded complexes with dan and these complexes can serve as substrate for t4 polynucleotide ligase (ec 6.5.1.1). the rate of phosphodiester formation was found to be approximately the same as for the double-stranded complex and, furthermore, the rate appears to be similar on the two strands in the complex. joining of dt1o also took place in the presence of the double-stranded complexes dan.dtn and dan.run. polyamines increase the rate of joining catalyzed by t4 polynucleot ... | 1978 | 687572 |
| [interaction between the hypothalamo-hypophyseal system and the thyroid gland during different age periods]. | age peculiarities of interaction of the hypothalamo-hypophysial system and the thyroid gland with consideration to direct and feed-back control were studied. significant alterations appear in old age in the hypothalamo-hypophysial system and the thyroid gland at the level of direct and feed-back control; there is an increase of sensitivity of the thyroid gland tissue to tsh, and of the hypothalamus-hypophysis--to the t4 effect. this rise of sensitivity is largely determined by the activation of ... | 1978 | 687803 |
| the structural organization of dna packaged within the heads of t4 wild-type, isometric and giant bacteriophages. | we present electron microscopic and x-ray diffraction evidence concerning the structural organization of condensed dna within a series of t4 bacteriophage with the following head morphologies: prolate (wild-type), isometric and giant (with greatly increased axial ratio). in all cases, the dna helix segments are locally parallel and 27 a apart. for the giant particles, we show that the dna forms a large coil whose axis is perpendicular to the axis of the phage tail. this evidence, combined with p ... | 1978 | 688382 |
| [determination of t4 with seralute-t4 ria kit]. | 1978 | 688639 | |
| [experimental and clinical evaluations of t4 radioimmunoassay kit by a solid phase method--konsul t4 ria]. | 1978 | 688679 | |
| specificity of partial exclusion of bacteriophage t2 in crosses with t4. | an attempt was made to isolate a bacteriophage t4 mutant generally disturbed in its ability to exclude the localized exclusion sensitivity determinants of t2 from the progeny of crosses. the method used was a modification of that used previously, which revealed t4 mutants unable to exclude more than one of the t2 sensitive sites specifically. one out of 1000 isolates from a mutagenized t4 am56:am32 stock was found to be mutated in its exclusion properties. however, the mutant was not generally e ... | 1978 | 690619 |
| assembly of the scaffolding core of bacteriophage t4 preheads. | 1978 | 691063 | |
| new late gene, dar, involved in the replication of bacteriophage t4 dna. iii. dna replicative intermediates of t4 dar and a gene 59 mutant suppressed by dar. | a mutation in the dar gene of phage t4 restored the arrested dna synthesis caused by the gene 59 mutation. we have studied the dna replicative intermediates in cells infected with a dar mutant and a dar-amc5 (gene 59) mutant by velocity sedimentation in neutral and alkaline sucrose gradients. in t4 dar-infected cells, compared to the wild type, three kinds of abnormalities were observed in dna replication (i) there were unusually rapidly sedimenting intermediates (800s). (ii) when centrifuged i ... | 1978 | 691106 |
| isolation and characterization of bacteriophage t4 mutant preheads. | to determine the function of individual gene products in the assembly and maturation of the t4 prehead, we have isolated and characterized aberrant preheads produced by mutations in three of the t4 head genes. mutants in gene 21, which codes for the t4 maturation proteases, produce rather stable preheads whose morphology and protein composition are consistent with a wild-type prehead blocked in the maturation cleavages. mutants in gene 24 produce similar structures which are unstable because the ... | 1978 | 691116 |
| the effect of blood infusion upon endurance capacity and ratings of perceived exertion. | the purpose of this investigation was to study the effect of blood infusion upon maximal endurance capacity and ratings of perceived exertaion (rpe). sixteen long-distance runners, 13 of whom were marathoners, undertook four trials (t1-t4) of a treadmill run to exhaustion over a five week period. criterion measures were time to exhaustion (te) and rpe during each t. data on hb, hct and rbcs were collected prior to each trial. based on te at t1, ss were matched and assigned to either the experime ... | 1978 | 692300 |
| 3'-terminal labelling of rna with t4 rna ligase. | 1978 | 692735 | |
| experimental studies concerning the mechanism of the thyroid-pineal interrelationship. i. the action of the pineal peptides on the thyroid gland. | subcutaneous administration of a pineal polypeptide extract, "crinofizin", to adult male wistar rats having the thyroid function inhibited by prolonged administration of mtu, has important effects on both the whole organism (slightly correcting the weight increase rate, loweri g cholesterolemia) and the thyroid gland (reducing thyroid hyperplasia and playing a part in various stages of thyroid hormones metabolism). thus under pineal treatment one can observe a clear tendency to return to the nor ... | 1978 | 694396 |
| the thyroglobulin variations during the thyroid surgery for polynodular goiter, hyperthyroidism and cancer. | a radioimmunoassay (ria) double antibody system for human thyroglobulin (tgl) was developed with a sensitivity of 2.5 ng/ml t3 and t4 did not interfere in the antibody tgl binding. the blood was collected pre-, intra- and 24 hrs post-thyroidectomy from 50 females and 4 males diagnosed as polynodular goiter, hyperthyroidism, chronic thyroiditis and thyroid cancer. the ratios of the intra- and post-operatory values versus pre-operatory values were calculated. the basal values in the patients havin ... | 1978 | 694400 |
| urinary excretion of thyroxine, triiodothyronine, 3,3',5'-triiodothyronine (reverse t3) and renal function in human newborns. | the urinary excretion and serum levels of thyroxine (t4), triiodothyronine (t3) and 3,3',5'-triiodothyronine (reverse t3) was estimated in a longitudinal study of human newborns. the maternal and cord blood was also studied. neonatal renal function was evaluated using endogenous creatinine clearance. in cord blood serum t3 was found to be lower than in maternal blood, but reverse t3 highly elevated. during the first 5 days of life serum t4 and t3 increased with maximum at 48 and 24 h in contrast ... | 1978 | 696180 |
| [the distribution of t4-igg bacteriophage on the surface of red blood cell obtained from the patient with acquired hemolytic anemia whose anti-globulin test was negative by direct and positive by indirect method (author's transl)]. | 1978 | 696193 | |
| thyroid function in hepatic schistosomiasis. | serum thyroxine (t4), serum tri-iodothyronine (t3-uptake) and the free thyroxine index in 17 men suffering from hepatosplenic schistosomiasis did not differ significantly from those of ten healthy male controls. there was no correlation between these values and serum protein levels or liver function tests. | 1978 | 697441 |
| [neonatal detection of hypothyroidism in the south-pyrenean region. results of 14,000 determinations of t4 in blood eluates collected on blotting-paper]. | screening for neonatal hypothyroidism has been undertaken in southern france by the estimation of t4 in the eluates of blood spots on filter paper. since march 1976, 14,000 estimations have been made and four cases of hypothyroidism with very low levels of t4 have been detected (less than 38 pg/2 spots). two cases had high tsh levels (greater than 200 microunits/2 spots). blood was taken from the hypothyroid babies on the 20th day of life, to check the findings and in all cases the thyroxine was ... | 1978 | 697532 |
| bacteriophage t4 tail length is controlled by its baseplate. | 1978 | 697770 | |
| a study of thyroid function in psychiatric in-patients. | the prevalence of abnormal serum total thyroxine (t4) and triiodothyronine (t3) concentrations were determined in 1,206 in-patients in two associated psychiatric hospitals. the biochemical pattern of primary hypothyroidism occurred in five females and one male (prevalence 0.5 per cent), but in only one patient was the diagnosis clinically obvious. eight patients (all female) were clinically hyperthyroid (prevalence 0.7 per cent), of whom six were previously undiagnosed. there was no evidence tha ... | 1978 | 698489 |
| carcinoma of the vocal cord: results of treatment and time-dose relationships. | a retrospective analysis has been done of 173 patients with epidermoid carcinoma of the vocal cord treated with radiation therapy at rush-presbyterian-st. luke's medical center between january 1970 and december )974. one hundred fifty-eight patients (91.3%) were early (t1, t2) glottic lesion and 10 were advanced (t3, t4) lesion. five (2.9%) were presented with positive cervical lymph nodes initially. of 158 patients who had t1, t2n0m0 glottic tumor, 146 had definitive radiation therapy and 12 ha ... | 1978 | 698909 |
| plasma triiodothyronine, thyroxine and thyrotrophin levels in germfree rats. | plasma t3, t4 and tsh levels in developing germfree rats were high, low and normal as compared with those in conventional counterparts. the high t3/t4 ratio in germfree rat plasma was lowered by cholestyramine feeding. | 1978 | 700040 |
| dna polymerase of phage t4 antimutator mutant cb121. a defective zinc metalloenzyme? | 1978 | 700112 | |
| effects of exercise, altitude, and food on blood hormone and metabolite levels. | measurements of blood glucose and plasma free fatty acids (ffa), thyroxine (t4), free thyroxine (ft4), triiodothyronine (t3), and thyroid-stimulating hormone (tsh) were made on samples taken from fed and fasted human subjects while at rest and immediately after 20 min moderate exercise. six subjects were studied on successive weeks before (la1), during (ha1, ha2, ha3), and after (la2) a 3-wk sojourn at high altitude (3,650 m). the subjects and location were the same as those used for the energy ... | 1978 | 701119 |
| specificity of initial synaptic contacts made on guinea-pig superior cervical ganglion cells during regeneration of the cervical sympathetic trunk. | 1. largely appropriate synaptic connexions are formed with neurones in the superior cervical ganglion at long intervals after interruption of the preganglionic nerve. in the present study we have assessed the accuracy of connexions during the early stages of re-innervation by observing end-organ responses to ventral root stimulation in vivo, and by recording intracellularly from ganglion cells during ventral root stimulation in isolated preparations. 2. appropriate, but weak, end-organ responses ... | 1978 | 702401 |
| gene expression and stability of mrna affected by dna-arrested synthesis in gene 59, 46, and 47 mutants of bacteriophage t4. | the effect of bacteriophage t4 gene 59 mutations (dna-arrested synthesis) on kinetics of dna synthesis, gene expression, and stability of mrna has been studied. when escherichia coli b was infected by a t4 gene 59 mutant, dna synthesis proceeded to increase linearly after initiation, but started to decrease at 8 min and was completely arrested at 12 min at 37 degrees c. at various incubation temperatures (20 to 42 degrees c), the initial rates and times of arrest of dna synthesis were different, ... | 1978 | 702642 |
| absence of phospholipase activity in bacteriophage t4. | we assayed phospholipase activity in t4dt+ and in t mutant phage grown under permissive and restrictive conditions. there was no correlation between the presence of the t+ gene product and phospholipase activity. phospholipase activity in phage lysates could be attributed to the presence of bacterial debris or to the use of commercial dnase which contains phospholipase. | 1978 | 702644 |
| [fundamental and clinical studies of radioimmunoassay for t4 ria (peg) kit (author's transl)]. | 1978 | 702935 | |
| optimum laboratory test combinations for thyroid function studies, selected by discriminant analysis. | in 430 patients with a variety of thyroid disorders, linear discriminant analysis was used to select laboratory test combinations giving optimum diagnostic efficiency in thyroid function studies. unexpectedly, tsh was found valuable in the diagnosis of hyperthyroidism and t3 in hypothyroidism. these test combinations were found optimal for the separation of euthyroidism/hyperthyroidism: t3, tsh and t4; euthyroidism/hypothyroidism: combined free thyroid hormone index (fti) and tsh; and hyperthyro ... | 1978 | 705229 |
| radioimmunoassay of triiodothyronine and thyroxine in capillary blood. | a radioimmunoassay technique for the estimation of t3 and t4 levels in capillary blood is described and evaluated in comparison to a simultaneously drawn and equally analyzed sample from the cubital vein. a total number of 236 samples thus received from the capillary and the vein from euthyroid, hypo- and hyper-thyroid patients were collected. for both t3 and t4 a good correlation (r = 0.94) was obtained. the clinical implication would especially be for paediatric practice. | 1978 | 705244 |
| ultrastructural identification of afferent fibers of cardiac origin in thoracic sympathetic nerves in the dog. | while cardiac afferent nerve activity has been recorded from the ventrolateral (vlcn) and ventromedial (vmcn) cardiac nerves, left dorsal and ventral ansae subclaviae, and left upper thoracic white rami communicantes, little anatomical evidence for the existence of afferent fibers in these nerves has been reported. this study was designed to characterize the normal ultrastructure of the above nerves and to identify afferent fibers in them through wallerian degeneration produced by dorsal root ga ... | 1978 | 707315 |
| surgical treatment of advanced carcinomas of the base of the tongue. | during the decade of 1964 through 1973, thirty-four patients with advanced squamous carcinoma of the base of the tongue (20 with t3 lesions and 14 with t4 lesions) were treated by surgical resection. these patients underwent an operative procedure as the only and definitive form of treatment. twenty-eight (82.3 per cent) presented with clinically positive cervical nodal metastases (4 staged n1, 13 staged n2, and 11 staged n3). the number of primary lesions controlled, cervical metastasis, and th ... | 1978 | 707732 |
| serum thyroid hormones changes in patients undergoing caesarean section under general or regional anaesthesia. | the effects of anaesthesia on serum thyroid hormones were studied in 32 pregnant young women undergoing caesarean section at term. eighteen patients received general anaesthesia and 14 lumbar extradural blockade. maternal serum concentrations of thyrotrophin (tsh), thyroxine (t4), triiodothyronine (t3) and reverse triiodothyronine (rt3) were measured using radioimmunoassay at 0, delivery and 24 h. there were no significant changes in tsh in the two groups. t4 concentrations decreased significant ... | 1978 | 708547 |
| hormonal changes in serum in young men during prolonged physical strain. | the endocrine response to severe physical strain including lack of sleep has been investigated in army personnel during a combat course of 5 days' duration. the thyroxine (t4) concentration in serum increased during the first 24 h, and then declined at a rate corresponding to a halflife of 7.6 days and on day 6 had reached the lowest level, 55 ng/ml. triiodothyronine (t3) displayed a similar pattern, although an increase during the first 24 h could not be demonstrated. within 48 h after the cour ... | 1978 | 710393 |
| [changes in serum thyrotropin, thyroxine and triiodothyronine after complete thyroidectomy (author's transl)]. | changes in serum tsh, t4 and t3 concentrations after complete thyroidectomy were observed for 4 weeks in 9 euthyroid patients with thyroid carcinoma. completeness of the thyroidectomy was confirmed by a 131 i scintigram performed one or two months after the operation. serum tsh levels rose progressively during the 4 weeks of observation, and a significant increase was noticed as early as 3 days after the thyroidectomy. serum t4 and t3 concentrations decreased significantly 3 days and 18 hrs, res ... | 1978 | 710646 |
| [bilateral carcinoma of the breast after radiotherapy and chemotherapy for hodgkin's disease (author's transl)]. | a 34-year-old patient had radiotherapy and chemotherapy for hodgkin's disease of the nodular sclerosing type 2 a thirteen years prior to the treatment of a right cancer of the breast in the stage m0 n1 t3. seven months later the patient had a left cancer of the breast in the stage m0 n0 t4. the literature is reviewed and the possibility of occurrance of secondary carcinoma following treatment of hodgkin's disease is discussed. | 1978 | 710884 |
| specific weight loss in hyperthyroidism. | to assess metabolic turnover in patients with hyperthyroidism weight loss in mg . kg-1 . min-1 (specific weight loss, swl) was measured by means of a new type of scale working on the buoyance principle with a minimal susceptibility of 10 mg per 100 kg. weight loss rate was significantly increased in hyperthyroid patients (n=22;swl, 22.0 +/-1.4 (se) mg. kg-1 . min-1) compared to health controls (n=11; swl, 10.0 +/-0.4 (se) mg . kg-1 . min-1). the fall in swl paralleled the decrease in thyroid hor ... | 1978 | 711136 |
| diet-hormone interrelationships in the rat. | twenty-eight-day old male rats were fed, either ad libitum or in restricted amounts, isoenergetic diets containing 2, 5, 10, 15, 25, or 50% lactalbumin and 5, 11.9, or 21.1% fat for 8 weeks. they were then killed and the plasma levels of triiodothyronine (t3), thyroxine (t4), insulin, glucagon, corticosterone, norepinephrine (ne), and epinephrine (e) were measured. dietary changes explained most of the variation in the plasma concentrations of t3, t4, insulin, and glucagon but less than 20% of t ... | 1978 | 712420 |
| isolation and characterization of precursors in t4 baseplate assembly. the complex of gene 10 and gene 11 products. | 1978 | 712843 | |
| enzymatic determinants of dna polymerase accuracy. theory of coliphage t4 polymerase mechanisms. | 1978 | 712851 | |
| the snell-dwarfmouse. i. general growth pattern, before and during growth hormone and thyroxine therapy. | in order to obtain more insight in the general growth pattern of the snell-mouse growth in length and weight of normal and dwarf snell-mice before and during treatment with human growth hormone (hgh), porcine growth hormone (pgh) and l-thyroxine (t4) were studied. in normal mice the length velocity has a peak at 1 1/2 week of age and diminishes gradually therafter. in contrast the weight velocity peaks at 4 1/2 week. these differences result in a biphasic pattern of the length/weight relationshi ... | 1978 | 716772 |
| the snell-dwarfmouse. ii. sulphate and thymidine incorporation in costal cartilage and somatomedin levels before and during growth hormone and thyroxine therapy. | costal cartilage activity ([35s]sulphate and [3h]thymidine incorporation) and somatomedin (sm) activity in normal snell-mice and dwarfmice before and during treatment with human growth hormone (hgh), porcine growth hormone (pgh) and l-thyroxine (t4) were studied, in order to obtain more insight in the interrelationship of these parameters with growth velocity. in normal mice endogenous (21 h incubation in medium with label) and plasma stimulated cartilage activity (21 h pre-incubation in medium, ... | 1978 | 716773 |
| circadian and 30 minutes variations in serum tsh and thyroid hormones in normal subjects. | ten normal young males were investigated in order to examine diurnal and short-term variations in serum tsh and serum thyroid hormones. in five subjects blood samples were obtained every 30 min during a 24 h period of daily life. a synchronous diurnal rhythm was found for free t3 and serum tsh with low levels in the day-time and higher levels at night. the mean increase from day to night was 15 and 140 per cent, respectively. there was a tendency to a similar rhythm in free t4, but the increase ... | 1978 | 716774 |
| influence of thiazides on thyroid parameters in man. | iodine metabolism and thyroid hormones in blood were studied in 19 men and 11 women who had been treated with thiazides for arterial hypertension from 1 month to 15 years. the results were compared with the findings from age-matched normal controls. no differences were found regarding 24-h 131i-thyroid uptake, thyroid iodide clearance, renal iodide clearance, plasma inorganic iodide, absolute iodine uptake (aiu), serum thyroxine (t4 (d)), resin t3 test (t3u) and tsh after trh. twenty-four-hour u ... | 1978 | 716775 |
| correlation of reverse-t3 and 3,3'-t2 (t2') plasma concentrations under physiological and experimental conditions in man. | t2' plasma levels are measured under different conditions and correlated to the repective rt3 concentrations. specific rias for t2' and rt3 are used. pharmacological doses of t3 cause an increase of plasma t2'; if t3 or t4 doses are administered to an athyroid patient which cause a similar level of plasma t3 the increase of t2' is much larger during t4 treatment. cord blood levels of t2' are 2--3-fold higher than in normal adults whereas rt3 concentrations are about 10 times higher than normal. ... | 1978 | 716776 |
| the effect of lithium on the peripheral turnover of thyroxine and triiodothyronine. | the effect of litium on the peripheral turnover of t4 and t3 was investigated in 14 euthyroid subjects using lymphocytes as target cells. lithium caused a dose-dependent rise in t4 turnover, which did not lead to increased t3 production, but no rise in t3 turnover. a further 3 patients with lithium induced hypothyroidism were studied. patients with high t4 turnover had high tsh values and in these patients lithium induced a decrease in t4 turnover. this may lead to the conclusion that the demons ... | 1978 | 716777 |
| correction of the biochemical effects of neonatal hypothyroidism by daily low doses of thyroxine. comparative effects of hyperthyroidism and these corrections. | the purpose of the present communication was to study the corrective effects of low daily thyroxine doses, on the cerebellum biochemical maturation in propylthiouracile (ptu)-treated rats during the early postnatal life. the corrected hypothyroid animals were compared to the normal, hypo- and hyperthyroid ones. the protein, rna and dna cerebellar contents were evaluated at 6, 10, 14, 18 and 35 days old animals. at all ages hypothyroidism and hyperthyroidism decreased cerebellar protein, rna and ... | 1978 | 716836 |
| surge of fetal plasma triiodothyronine before birth in sheep. | plasma thyroid hormone and cortisol concentrations were measured from early third trimester to delivery in seven pregnant ewes and their fetuses. a surge in fetal plasma triiodothyronine was found during the six days prior to delivery, the mean values rising from less than 30 to 125 ng. per deciliter. during this period the fetal plasma cortisol also increased from less than 1 to 8.1 microgram per deciliter. during this period there was no significant change in fetal plasma thyroxine (t4) or rev ... | 1978 | 717450 |
| toxicity of leucaena leucocephala. the effect of iodine and mineral supplements on penned steers fed a sole diet of leucaena. | steers fed a sole diet of leucaena leucocephala cv. peru (leucaena), rapidly developed a hypothyroid condition. total serum thyroxine (t4) levels declined from c 120 n mol litre-1 to 13 n mol litre-1 within six weeks of full leucaena feeding. associated with the hypothyroidism was a declined in feed intake, poor weight gain, hair loss, excessive salivation and the development of lesions on the oesophagus of some animals. light steers (119 kg) were more severely affected than heavy steers (220 kg ... | 1978 | 718558 |
| sequence studies on mouse l-cell satellite dna by base-specific degradation with t4 endonuclease iv. | the base sequence of mouse l-cell satellite dna was investigated by degradation of the two separated complementary strands with the base specific enzyme, t4 endonuclease iv. digestion of the heavy strand dna released a limited number of oligonucleotides which were separated by ionophoresis/homochromatography, isolated, and sequenced by the 'wandering spot' method. the light strand dna was resistant to digestion with t4 endonuclease iv and no detectable amounts of oligonucleotides were released. ... | 1978 | 718912 |
| the relationship between circadian variations in circulating thyrotrophin, thyroid hormones and prolactin. | half-hourly blood samples were taken from six clinically euthyroid men over a continuous period of 24 h. their concentrations of total thyroxine (t4), total triiodothyronine (t3), thyrotrophin (tsh) and prolactin (prl) were assessed together with the degree of unsaturation of thyroid hormone binding proteins as determined by the thyroid hormone uptake test (thut). both t3 and t4 were also measured in urine samples collected serially during the same 24 h period. significant circadian changes in s ... | 1978 | 719905 |
| thyroxine, triiodothyronine and thyrotrophin levels in meningococcal meningitis, typhoid fever and other febrile conditions. | thyroid status was estimated serially by measuring triiodothyronine (t3), thyroxine (t4) and thyrotrophin (htsh) in 20 patients suffering from meningococcal meningitis, typhoid fever and other acute febrile illnesses. significantly low t3 and only slightly increased t4 were observed in all the patients. htsh was normal in all of these. a significant reciprocal relationship was found between the degree of fever and fall in t3 concentrations. t3 tended to rise in patients who recovered but in thos ... | 1978 | 719910 |
| [t4 radioimmunoassay using a solid phase method--evaluation of spak t4 ria kit]. | 1978 | 719929 | |
| [determination of blood thyroxine values using ria-gnost t4]. | 1978 | 719930 | |
| [effect of thyroxine on the hypothalamic concentration of biogenic amines in rats of different ages]. | male rats of 2.0--2.5 and 8--12 months old received intraperitoneally thyroxin t4 (2 mcg/100 g daily during 8 days) or placebo. t4 significantly increased the noradrenaline concentration in the young rats' hypothalamus. no difference was revealed in concentrations of dophamine, 5--oiaa, or serotonin in either group. the data obtained are discussed from the standpoint of a possible mechanism of changing thresholds for the homeostatic inhibition in the hypothalamo-hypophyseal-thyroid system with a ... | 1978 | 720666 |
| the genome of calliphora. analysis by dna reassociation kinetics. | the size and nucleotide sequence complexity of the calliphora vicina genome has been determined from the kinetics of reassociation of its dna. unique sequence dna comprises 80% of the genome and the remainder is divided into medium (14%) and highly repetitive sequences (6%), which are repeated roughly 150 times and more. the size of the calliphora genome was calculated relative to the dna from t4-phage to be 1.5--1.9 x 10(11) daltons. | 1978 | 721071 |
| screening of the thyroid function of newborns in southern belgium. | data on t4 and tsh values derived from a voluntary screening programme of thyroid function in belgium are presented. significant differences in t4 values according to sex, maturity and birthplace are shown. | 1978 | 721360 |
| hemodialysis and thyroid functions in children. | evaluation of thyroid functions in 16 children receiving maintenance hemodialysis for a mean duration of 17 months showed that the serum t3, t4 and tsh were below normal concentrations for age. however, the measurements of these variables before and after the dialysis procedure did not show any significant changes. the possibility that the chronic uremia may give rise to abnormal tsh secretion and low t3, t4 concentrations is not tested in this study. | 1978 | 721993 |
| reactions at the termini of trna with t4 rna ligase. | t4 rna ligase will catalyze the addition of nucleoside 3', 5'-bisphosphates onto the 3' terminus of trna resulting in trna molecule one nucleotide longer with a 3' terminal phosphate. under appropriate conditions the reaction is quantitative and, if high specific radioactivity bisphosphates are used, it provides an efficient means for in vitro labeling of trna. although the 3' terminal hydroxyl is a good acceptor, the 5' terminal phosphate in most trna's is not an effective donor in the rna liga ... | 1978 | 724498 |
| [functional state of the pituitary-thyroid system of women during pregnancy]. | functional condition of the hypophysio-thyroid system was studied in physiological pregnancy by protein-bound iodine, t4, t3, thyrotropic hormone indices; the function proved to become more intense with the advance of pregnancy. a significant change of the t3 level during the early periods of pregnancy is possibly connected with the high hormone uptake at that period. a sharp elevation of the hormone-binding capacity of the blood serum proteins prevented the development of hyperthyroidism, this ... | 1978 | 724674 |