Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| epstein-barr virus micrornas are expressed in patients with chronic lymphocytic leukemia and correlate with overall survival. | although numerous studies highlighted the role of epstein-barr virus (ebv) in b-cell transformation, the involvement of ebv proteins or genome in the development of the most frequent adult leukemia, chronic lymphocytic leukemia (cll), has not yet been defined. we hypothesized that ebv micrornas contribute to progression of cll and demonstrated the presence of ebv mirnas in b-cells, in paraffin-embedded bone marrow biopsies and in the plasma of patients with cll by using three different methods ( ... | 2015 | 26288818 |
| [treatment outcomes and prognostic analysis of 61 epstein-barr virus-associated hemophagocytic lymphohistiocytosis]. | to investigate the outcomes, survival status, and the prognostic factors of epstein-barr virus-associated hemophagocytic lymphohistiocytosis (ebv-hlh) patients. | 2015 | 26134018 |
| erratum: epstein-barr virus vaccines. | [this corrects the article doi: 10.1038/cti.2014.27.]. | 2015 | 26131364 |
| generation of recombinant human igg monoclonal antibodies from immortalized sorted b cells. | finding new methods for generating human monoclonal antibodies is an active research field that is important for both basic and applied sciences, including the development of immunotherapeutics. however, the techniques to identify and produce such antibodies tend to be arduous and sometimes the heavy and light chain pair of the antibodies are dissociated. here, we describe a relatively simple, straightforward protocol to produce human recombinant monoclonal antibodies from human peripheral blood ... | 2015 | 26132628 |
| the expression of ebv-encoded lmp1 in young patients with lupus nephritis. | one of the major disease manifestations of systemic lupus erythematosus (sle) is lupus nephritis (ln), and the underlying mechanisms are not yet understood. epstein-barr virus (ebv) reactivation was associated with the induction of sle, with ebv-encoded latent membrane protein1 (lmp1) plays a vital role in this process. although it was reported that ln was associated with lmp1, most of these results are from patients with ages differed greatly (range, 10-56 years). given the increased prevalence ... | 2015 | 26131206 |
| anaplastic large-cell lymphoma in aids. | aids-related malignancies may alter clinical courses and result in death in critically ill patients. we present a case of a newly diagnosed aids patient with pneumocystis jiroveci pneumonia, epstein-barr virus, and cytomegalovirus infections who was found to have widely metastatic kinase-negative anaplastic large-cell lymphoma. this case demonstrates the diversity in the malignant presentation of hiv-infected patients, outside of the more commonly observed non-hodgkin lymphomas. | 2015 | 26130896 |
| development of a time-resolved fluorescence immunoassay for epstein-barr virus nuclear antigen 1-immunoglobulin a in human serum. | enzyme-linked immunosorbent assay (elisas) specific for epstein-barr virus nuclear antigen 1 (ebna1)-immunoglobulin a (iga) are most commonly used in the clinical diagnosis of ebv infection. but they have a low sensitivity and the enzyme-labeled antibodies are unstable. in this study, a novel immunoassay based on an indirect time-resolved fluoroimmunoassay (trfia) was developed. microtiter plates were coated with recombinant ebna1. we used eu(3) (+)-labeled anti-human iga as probe. the precision ... | 2015 | 26129643 |
| integrated mirna-mrna analysis of epstein-barr virus-positive nasopharyngeal carcinoma. | this study aims to identify the crucial mirnas in epstein-barr virus-positive nasopharyngeal carcinoma (npc) and their target genes. gene expression profile data (gse12452) that included 31 npc and 10 normal nasopharyngeal tissue specimens were downloaded. differentially expressed genes (degs) were identified using significance analysis of microarrays. the underlying function of degs was predicted via gene ontology and kyoto encyclopedia of genes and genomes pathway enrichment analyses. the mirn ... | 2015 | 26125802 |
| allogeneic hematopoietic stem cell transplantation in children with aplastic anemia. | the aim of this study was to prospectively investigate the efficacy and safety of fully matched allogeneic hematopoietic stem cell transplants in children with severe aplastic anemia in china. a total of twenty patients with severe aplastic anemia were enrolled in our study. thirteen cases underwent transplantation with fully human leukocyte antigen (hla)-matched, granulocyte-colony stimulating factor (g-csf)-primed bone marrow and peripheral blood stem cells (pbscs) from matching sibling donors ... | 2015 | 26125718 |
| toll-like receptor 3 expression and function in childhood idiopathic nephrotic syndrome. | the efficacy of steroids and immunosuppressive treatments in idiopathic nephrotic syndrome (ins) hints at the implication of immune cells in the pathophysiology of the disease. toll-like receptor (tlr) dysfunctions are involved in many kidney diseases of immune origin, but remain little described in ins. we investigated the expression and function of tlrs in peripheral blood mononuclear cells (pbmc) of ins children, including 28 in relapse, 23 in remission and 40 controls. no child had any sign ... | 2015 | 26123900 |
| a herpesvirus specific motif of epstein-barr virus dna polymerase is required for the efficient lytic genome synthesis. | epstein-barr virus (ebv) is associated with several malignancies, including burkitt lymphoma and nasopharyngeal carcinoma. to overcome such disorders, understanding the molecular mechanisms of the ebv replication is important. the ebv dna polymerase (pol) is one of the essential factors for viral lytic dna replication. although it is well known that its c-terminal half, possessing dna polymerase and 3'-5' exonuclease activity, is highly conserved among family b pols, the nh2-terminal half has ye ... | 2015 | 26123572 |
| a slow progressor hiv-infected boy developing quadriplegia with evidence of epstein-barr virus associated smooth muscle tumour of the cervical spinal cord. | the authors report a case of slowly progressive hiv in an 11-year-old boy whose initial presenting aids-defining symptom was progressive quadriplegia with complete cord compression and pathological confirmation of epstein-barr virus associated smooth muscle tumour. despite tumour removal, quadriplegia persisted as did ventilator dependence. | 2015 | 26123466 |
| are epstein-barr virus-positive and -negative gastric carcinomas, with lymphoid stroma, single entity or different entities? | 2015 | 26122759 | |
| the at-hook dna binding ability of the epstein barr virus ebna1 protein is necessary for the maintenance of viral genomes in latently infected cells. | epstein barr virus (ebv) is a human tumor virus that is causally linked to malignancies such as burkitt׳s lymphoma, and gastric and nasopharyngeal carcinomas. tethering of ebv genomes to cellular chromosomes is required for the synthesis and persistence of viral plasmids in tumor cells. however, it is not established how ebv genomes are tethered to cellular chromosomes. we test the hypothesis that the viral protein ebna1 tethers ebv genomes to chromosomes specifically through its n-terminal at-h ... | 2015 | 26122471 |
| does ebv alter the pathogenesis of malaria? | plasmodium falciparum infections have been implicated in immune deficiencies resulting in ineffective control of epstein-barr virus, thereby increasing the risk of endemic burkitt lymphoma in children. however, the impact of epstein-barr virus infections on the development of immunity to p. falciparum has not been studied in depth. in this review, we examine novel findings from animal co-infection models and human immuno-epidemiologic studies to speculate on the impact of acute gammaherpesvirus ... | 2015 | 26121587 |
| proteomics and transcriptomics of bjab cells expressing the epstein-barr virus noncoding rnas eber1 and eber2. | in epstein-barr virus (ebv) latent infection, the ebv-encoded rnas eber1 and eber2 accumulate in the host cell nucleus to ~10(6) copies. while the expression of ebers in cell lines is associated with transformation, a mechanistic explanation of their roles in ebv latency remains elusive. to identify eber-specific gene expression features, we compared the proteome and mrna transcriptome from bjab cells (an ebv-negative b lymphoma cell line) stably transfected with an empty plasmid or with one car ... | 2015 | 26121143 |
| th22 cells increase in poor prognosis multiple myeloma and promote tumor cell growth and survival. | there is increased production of plasmacytoid dendritic cells (pdcs) in the bone marrow (bm) of multiple myeloma (mm) patients and these favor th22 cell differentiation. here, we found that the frequency of interleukin (il)-22(+)il-17(-)il-13(+) t cells is significantly increased in peripheral blood (pb) and bm of stage iii and relapsed/refractory mm patients compared with healthy donors and patients with asymptomatic or stage i/ii disease. th22 cells cloned from the bm of mm patients were ccr6( ... | 2015 | 26155400 |
| successful treatment of epstein-barr virus-related post-transplant lymphoproliferative disease with central nervous system involvement following allogeneic haematopoietic stem cell transplantation - a case study. | post-transplant lymphoproliferative disease (ptld) is a rare but severe form of epstein-barr virus (ebv)-driven complication that develops in patients after haematopoietic stem cell transplantation. in rare cases it manifests as primary central nervous system (cns) involvement, which is thought to be the most unfavourable localisation with respect to outcome. disease confined to the cns is much more challenging than systemic ptld, and one of the contributing factors is the limited drug penetrati ... | 2015 | 26155195 |
| targeting ctcf to control virus gene expression: a common theme amongst diverse dna viruses. | all viruses target host cell factors for successful life cycle completion. transcriptional control of dna viruses by host cell factors is important in the temporal and spatial regulation of virus gene expression. many of these factors are recruited to enhance virus gene expression and thereby increase virus production, but host cell factors can also restrict virus gene expression and productivity of infection. ccctc binding factor (ctcf) is a host cell dna binding protein important for the regul ... | 2015 | 26154016 |
| epstein-barr virus proteins ebna3a and ebna3c together induce expression of the oncogenic microrna cluster mir-221/mir-222 and ablate expression of its target p57kip2. | we show that two host-encoded primary rnas (pri-mirs) and the corresponding microrna (mir) clusters--widely reported to have cell transformation-associated activity--are regulated by ebna3a and ebna3c. utilising a variety of ebv-transformed lymphoblastoid cell lines (lcls) carrying knockout-, revertant- or conditional-ebv recombinants, it was possible to demonstrate unambiguously that ebna3a and ebna3c are both required for transactivation of the oncogenic mir-221/mir-222 cluster that is express ... | 2015 | 26153983 |
| p-glycoprotein is expressed and causes resistance to chemotherapy in ebv-positive t-cell lymphoproliferative diseases. | epstein-barr virus-positive t-cell lymphoproliferative diseases (ebv-t-lpds) are rare lymphomas with poor prognosis. although chemotherapeutic strategies such as chop have been often selected, they have exhibited only limited efficacy. to clarify the mechanism of chemoresistance, we examined p-glycoprotein (p-gp) expression. p-gp acts as an energy-dependent efflux pump that excretes drugs from the cytoplasm, resulting in low-intracellular drug concentrations and poor sensitivity to chemotherapy. ... | 2015 | 26153782 |
| epstein-barr virus in the enlarged salivary tissues of patients with igg4-related disease. | immunoglobulin g4-related disease (igg4-rd) is a recently recognized disease entity characterized by high-serum igg4 concentration and igg4-producing plasma cell production with fibrotic or sclerotic changes in affected organs. we aimed to clarify the roles of epstein-barr virus (ebv) in patients with igg4-rds. | 2015 | 26152762 |
| the role of viral co-infection in hiv-associated non-aids-related cancers. | hiv-infected individuals are at increased risk for most types of cancer, including those typically classified as non-aids-defining cancers (nadcs). this increased risk is likely multifactorial, but a prominent risk factor for the increased rate of some cancers is co-infection with oncogenic viruses. anal cancer, hepatocellular carcinoma, and hodgkin lymphoma are three of the most common nadcs, and they are associated with co-infection with human papillomavirus, hepatitis b and c, and epstein bar ... | 2015 | 26152660 |
| nasopharyngeal epstein-barr virus load: an efficient supplementary method for population-based nasopharyngeal carcinoma screening. | serological detection of epstein-barr virus (ebv) antibodies is frequently used in nasopharyngeal carcinoma (npc) mass screening. however, the large number of seropositive subjects who require close follow-up is still a big burden. the present study aimed to detect the nasopharyngeal ebv load in a high-risk population seropositive for antibodies against ebv, as well as to examine whether assay for nasopharyngeal ebv dna load might reduce the number of high-risk subjects for follow-up and improve ... | 2015 | 26151639 |
| chronic active epstein-barr virus infection with cutaneous and sinus lymphoproliferation in a white female patient with 25 years' follow-up: an original case report. | chronic active epstein-barr virus infection (caebv) is characterized by chronic infectious mononucleosis-like symptoms associated with very high viral load, as assessed by quantitative polymerase chain reaction. we present an unusual case in a french woman who was followed up over 25 years with cutaneous and sinus lymphoproliferation. this white woman presented with a long history of recurrent cutaneous necrotic papules of the skin, which started during childhood and healed spontaneously with de ... | 2015 | 26148205 |
| implication of leptin-signaling proteins and epstein-barr virus in gastric carcinomas. | we investigated the clinicopathological implications of leptin-signaling proteins and epstein-barr virus (ebv)-infection status in gastric carcinomas. immunohistochemistry for leptin signalling-related proteins (leptin, leptin-receptor, pstat3, erk, pakt, mtor and hif-1 alpha), and in situ hybridization for ebv-encoded small rnas was performed in 343 cases of gastric carcinomas. the sirna against leptin-receptor was transfected into three stomach cancer cell lines, and western blot for caspase 3 ... | 2015 | 26147886 |
| post-transplant lymphoproliferative disorders with naso- and oropharyngeal manifestation. | the nasopharyngeal/oropharyngeal lymphatic tissues represent the anatomical site of epstein-barr virus (ebv) entry. post-transplant lymphoproliferative disorders (ptld) are often associated with ebv, but little is known about the characteristics of nasopharyngeal/oropharyngeal mass-forming ptld. retrospective evaluation of our own ptld database (n = 79) and the pubmed(®) database (n = 61) has been performed. sinonasal/oro-/nasopharyngeal lymphatic masses were early lesions (n = 54/140, 38.5%), p ... | 2015 | 26147593 |
| epstein-barr virus modulates host cell microrna-194 to promote il-10 production and b lymphoma cell survival. | epstein-barr virus (ebv) is a γ-herpesvirus that is linked to the development of posttransplant lymphoproliferative disorder (ptld) in solid organ recipients. we previously demonstrated that ebv(+) b cell lymphoma cell lines isolated from patients with ptld produce human il-10 as an autocrine growth factor. however, little is known regarding il-10 regulation in b cells. here we show that ebv infection markedly alters the expression of host b cell microrna, a class of small noncoding rna that is ... | 2015 | 26147452 |
| granulomatous lymphoproliferative disorders: granulomatous slack skin and lymphomatoid granulomatosis. | granulomatous cutaneous t-cell lymphomas (ctcl) and lymphomatoid granulomatosis are considered granulomatous lymphoproliferative disorders. the most common types of granulomatous ctcl are granulomatous mycosis fungoides and granulomatous slack skin. lymphomatoid granulomatosis is a rare epstein-barr virus driven lymphoproliferative disorder. this article reviews the etiopathogenesis, clinical presentation, systemic associations, and management of both granulomatous slack skin syndrome and lympho ... | 2015 | 26143428 |
| the aliens inside human dna: herv-w/msrv/syncytin-1 endogenous retroviruses and neurodegeneration. | the human genome contains remnants of ancestral retroviruses now endogenously transmitted, called human endogenous retroviruses (hervs). hervs can be variably expressed, and both beneficial and detrimental effects have described. this review focuses on the msrv and syncytin-1 herv-w elements in relationship to neurodegeneration in view of their neuro-pathogenic and immune-pathogenic properties. multiple sclerosis (ms) and a neurodegenerative disease (neuroaids) are reported in this review. in vi ... | 2015 | 26142666 |
| aggressive natural killer-cell neoplasm presenting in the marrow: a report of two cases including one with gains of chromosomes 4q and 9p. | aggressive nature killer (nk)-cell neoplasm includes aggressive nk-cell leukemia (ankl) and extranodal nk/t-cell lymphoma (enktl), nasal type. ankl is rare and is characterized by a systemic neoplastic proliferation of nk-cells, usually with a leukemic presentation. enktl is a predominantly extranodal lymphoma, occurring mainly in the upper aerodigestive tract. both are aggressive neoplasms strongly associated with epstein-barr virus (ebv). here we report two patients with aggressive nk-cells ne ... | 2015 | 26141723 |
| epstein-barr virus-induced gene 3-deficiency leads to impaired antitumor t-cell responses and accelerated tumor growth. | epstein-barr virus-induced gene 3 (ebi3) encoded protein can form heterodimers with il-27p28, and il-12p35 to form il-27, and il-35. however, il-27 stimulates, whereas il-35 inhibits antitumor t-cell responses. il-27 also limits the foxp3(+) regulatory t cell (treg) population, whereas il-35 has been shown to expand tregs and foster treg suppressive functions. it remains unclear which group of forces are dominant during antitumor t-cell responses. in this study, we evaluated the tumor growth and ... | 2015 | 26140252 |
| case of plasmablastic lymphoma of the sigmoid colon and literature review. | plasmablastic lymphoma (pbl) is a rare form of non-hodgkin's lymphoma that is associated with human immunodeficiency virus (hiv) infection. although pbl is most commonly observed in the oral cavity of hiv-positive patients, it can also be observed at extra-oral sites in hiv-negative patients. this report represents an unusual case of hiv-negative pbl that occurred in the sigmoid colon. this patient had a history of systemic lupus erythematosus and an underlying immunosuppressive state from long ... | 2015 | 26140010 |
| an adolescent with hereditary spherocytosis who presented with splenic infarction. | a 16-year-old male patient with known hereditary spherocytosis presented with a 4-day history of chest pain and lethargy. on admission, he had a low-grade fever and was grossly anaemic; examination revealed splenomegaly. an ultrasound scan confirmed splenomegaly with areas of splenic infarction. subsequent tests suggested possible epstein-barr virus infection. the patient recovered well and had a functional spleen on discharge. this case report presents an unusual complication of isolated heredi ... | 2015 | 26139647 |
| epstein-barr virus-encoded microrna bart1 induces tumour metastasis by regulating pten-dependent pathways in nasopharyngeal carcinoma. | epstein-barr virus (ebv), aetiologically linked to nasopharyngeal carcinoma (npc), is the first human virus found to encode many mirnas. however, how these viral mirnas precisely regulate the tumour metastasis in npc remains obscure. here we report that ebv-mir-bart1 is highly expressed in npc and closely associated with pathological and advanced clinical stages of npc. alteration of ebv-mir-bart1 expression results in an increase in migration and invasion of npc cells in vitro and causes tumour ... | 2015 | 26135619 |
| circulating human papillomavirus dna as a marker for disease extent and recurrence among patients with oropharyngeal cancer. | circulating epstein-barr virus dna is a predictor of disease recurrence in patients with nasopharyngeal carcinoma. circulating human papillomavirus (hpv) dna has been detected in the sera of some patients with hpv-positive squamous cell carcinoma of the oropharynx (opc). the goal of the current study was to determine whether pretreatment serum hpv dna is a useful biomarker for disease recurrence in patients with hpv-positive opc. | 2015 | 26094818 |
| post-transplantation malignancy after kidney transplantation in turkey. | kidney transplantation is the best treatment option for end-stage renal disease patients. increased incidence of post-transplantation malignancy can be caused by immunosuppressive drugs and some oncogenic infections. the aim of this study is to show the incidence of post-transplantation malignancy in patients who had surgery and were followed up in the organ transplant center, medical park antalya, antalya, turkey. | 2015 | 26093732 |
| role of mirna in cancer diagnosis, prognosis, therapy and regulation of its expression by epstein-barr virus and human papillomaviruses: with special reference to oral cancer. | micrornas (mirnas) belong to class of small non-coding rnas that regulate numerous biological processes by targeting broad set of messenger rnas. research on mirna-based biomarkers has witnessed phenomenal growth, owing to non-invasive nature of mirna based screening assays and their sensitivity and specificity in detecting cancers. their discovery in humans in 2000 has led to an explosion in research in terms of their role as biomarker, therapeutic target and trying to elucidate their function. ... | 2015 | 26093389 |
| effect of interleukins on antibody production by epstein-barr virus transformed b cells. | during the past few decades, monoclonal antibodies (mabs) have become an increasingly used tool in diagnostics, therapeutics, and biomedical research. several methods have been employed to produce mabs, one of which is the immortalization of b cells by epstein-barr virus (ebv). despite its simplicity, this procedure was never routinely adopted due to its poor efficiency and short-lived antibody (ab) production. various adjustments to the basic procedure were introduced, including the addition of ... | 2015 | 26090593 |
| generation of human ipscs from cells of fibroblastic and epithelial origin by means of the orip/ebna-1 episomal reprogramming system. | the prospect of therapeutic applications of the induced pluripotent stem cells (ipscs) is based on their ability to generate virtually any cell type present in human body. generation of ipscs from somatic cells has opened up new possibilities to investigate stem cell biology, to better understand pathophysiology of human diseases, and to design new therapy approaches in the field of regenerative medicine. in this study, we focus on the ability of the episomal system, a non-viral and integration- ... | 2015 | 26088261 |
| epstein-barr virus dna load in chronic lymphocytic leukemia is an independent predictor of clinical course and survival. | the relation between epstein-barr virus (ebv) dna load and clinical course of patients with chronic lymphocytic leukemia (cll) is unknown. we assessed ebv dna load by quantitative pcr at cll presentation in mononuclear cells (mnc) of 220 prospective patients that were enrolled and followed-up in two major institutions. in 20 patients ebv dna load was also assessed on plasma samples. forty-one age-matched healthy subjects were tested for ebv dna load on mnc. findings were validated in an independ ... | 2015 | 26087198 |
| host range restriction of epstein-barr virus and related lymphocryptoviruses. | epstein-barr-related herpesviruses, or lymphocryptoviruses (lcv), naturally infect humans and nonhuman primates (nhp), but their host range is not well characterized. using lcv and b cells from multiple species of hominidae and cercopithecidae, we show that lcv can immortalize b cells from some nonnative species but that growth transformation is restricted to b cells from their own family of hominoids or old world nhp, suggesting a high degree of lcv adaptation to their natural primate host. | 2015 | 26085168 |
| assembly of epstein-barr virus capsid in promyelocytic leukemia nuclear bodies. | the epstein-barr virus (ebv) capsid contains a major capsid protein, vca; two minor capsid proteins, bdlf1 and borf1; and a small capsid protein, bfrf3. during the lytic cycle, these capsid proteins are synthesized and imported into the host nucleus for capsid assembly. this study finds that ebv capsid proteins colocalize with promyelocytic leukemia (pml) nuclear bodies (nbs) in p3hr1 cells during the viral lytic cycle, appearing as nuclear speckles under a confocal laser scanning microscope. in ... | 2015 | 26085145 |
| lta + 252a > g polymorphism is associated with risk of nasal nk/t-cell lymphoma in a chinese population: a case-control study. | nasal nk/t-cell lymphoma is a rare type of lymphoma in caucasian individuals, but is relatively common in asian populations. genetic variants in immune and inflammatory response genes may thus be associated with the risk of developing lymphoma. here, we investigated the association between immuno-modulatory gene polymorphisms and risk for nasal nk/t-cell lymphoma in a chinese population. | 2015 | 26108796 |
| proteomic analysis of a nasopharyngeal carcinoma cell line and a nasopharyngeal epithelial cell line. | nasopharyngeal carcinoma (npc) is an epithelial malignancy exhibiting a strong geographic preference and a close association with epstein-barr virus (ebv). the aim of this study was to investigate the precise mechanism of nasopharyngeal epithelial-to-npc tumorigenesis and to identify possible biomarkers and targets for therapy. | 2015 | 26108243 |
| recombinant murine gamma herpesvirus 68 carrying kshv g protein-coupled receptor induces angiogenic lesions in mice. | human gamma herpesviruses, including kaposi's sarcoma-associated herpesvirus (kshv) and epstein-barr virus (ebv), are capable of inducing tumors, particularly in in immune-compromised individuals. due to the stringent host tropism, rodents are resistant to infection by human gamma herpesviruses, creating a significant barrier for the in vivo study of viral genes that contribute to tumorigenesis. the closely-related murine gamma herpesvirus 68 (γhv68) efficiently infects laboratory mouse strains ... | 2015 | 26107716 |
| epstein-barr virus positive diffuse large b-cell lymphoma predict poor outcome, regardless of the age. | epstein-barr virus (ebv) positive diffuse large b-cell lymphoma (dlbcl) of the elderly is defined as patients older than 50 years alone. however, recent studies showed young patients with sound immune status could also be affected. in this study, we investigated the clinical features and outcomes of patients with ebv positive dlbcl in the different age groups using different eber cut-off values. the prevalence of ebv positive dlbcl was 14.0% (35/250) and 10.4% (26/250) for eber cut-off of 20% an ... | 2015 | 26202875 |
| the epstein-barr virus bdlf4 gene is required for efficient expression of viral late lytic genes. | epstein-barr virus (ebv) is a gammaherpesvirus, associated with infectious mononucleosis and various types of malignancy. we focused here on the bdlf4 gene of ebv and identified it as a lytic gene, expressed with early kinetics. viral late gene expression of the bdlf4 knockout strain was severely restricted; this could be restored by an exogenous supply of bdlf4. these results indicate that bdlf4 is important for the ebv lytic replication cycle, especially in late gene expression. | 2015 | 26202235 |
| noncoding rna-guided recruitment of transcription factors: a prevalent but undocumented mechanism? | high-fidelity binding of transcription factors (tfs) to dna target sites is fundamental for proper regulation of cellular processes, as well as for the maintenance of cell identity. recognition of cognate binding motifs in the genome is attributed by and large to the dna binding domains of tfs. as an additional mode of conferring binding specificity, noncoding rnas (ncrnas) have been proposed to assist associated tfs in finding their binding sites by interacting with either dna or rna in the vic ... | 2015 | 26200477 |
| gender influence in ebv antibody response in multiple sclerosis patients from kuwait. | epstein-barr virus (ebv) infection is implicated with multiple sclerosis (ms) risk, exacerbation, and progression. the hla-drb1*1501 haplotype is a strong ms risk factor consistently documented in ms populations. there are no studies of ebv infections and hla-drb1*1501 haplotype associating with ms from kuwait where ms prevalence has increased significantly. | 2015 | 26198919 |
| immunodeficiency-associated viral oncogenesis. | several viruses with different replication mechanisms contribute to oncogenesis by both direct and indirect mechanisms in immunosuppressed subjects after solid organ transplantation, after allogeneic stem cell transplantation, or with human immunodeficiency virus (hiv) infection. epstein-barr virus (ebv), human papillomavirus (hpv), kaposi sarcoma herpesvirus (kshv), human t-cell lymphotropic virus type 1 (htlv-1) and merkel cell polyoma virus (mcv) are the main viruses associated with the devel ... | 2015 | 26197213 |
| b cell-derived circulating granzyme b is a feature of acute infectious mononucleosis. | granzyme b (gzmb) is a serine protease best known for inducing target cell apoptosis when released by cytotoxic t lymphocytes (ctls) or natural killer cells with pore-forming perforin. as a result, gzmb detected in the serum of virus-infected individuals has typically been attributed to these sources. here, we show that patients with recently diagnosed infectious mononucleosis caused by epstein-barr virus (ebv) have high circulating levels of gzmb that may be derived from infected b cells early ... | 2015 | 26191409 |
| [expression and clinical pathological significance of eber, pten and vegf in angioimmunoblastic t-cell lymphoma]. | to investigate the expression and clinical pathological significance of eb virus (epstein-barr virus, ebv), pten and vegf in angioimmunoblastic t -cell lymphoma (aitl). | 2015 | 26117013 |
| in silico discovery and modeling of non-coding rna structure in viruses. | this review covers several computational methods for discovering structured non-coding rnas in viruses and modeling their putative secondary structures. here we will use examples from two target viruses to highlight these approaches: influenza a virus-a relatively small, segmented rna virus; and epstein-barr virus-a relatively large dna virus with a complex transcriptome. each system has unique challenges to overcome and unique characteristics to exploit. from these particular cases, generically ... | 2015 | 26116541 |
| the presence of epstein-barr virus significantly impacts the transcriptional profile in immunodeficiency-associated burkitt lymphoma. | burkitt lymphoma (bl) is an aggressive neoplasm derived from mature, antigen-experienced b-lymphocytes. three clinical/epidemiological variants have been recognized, named sporadic, endemic and immunodeficiency-associated bl (id-bl). although they are listed within a unique entity in the current who classification, recent evidence indicated genetic and transcriptional differences among the three sub-groups. further, the presence of latently persisting epstein-barr virus (ebv) has been associated ... | 2015 | 26113842 |
| l-asparaginase monotherapy for ebv-positive t/nk lymphoproliferative diseases: a pilot study. | we investigated the effects of l-asparaginase (l-asp) on epstein-barr virus (ebv)-positive t/nk lymphoproliferative diseases (ebv-t/ nk-lpds). seven doses of l-asp (6,000 u/m2) were administered intravenously, with one dose administered on every alternate day. five consecutive patients were enrolled. three patients completed the treatment. the clinical symptoms resolved in 1 patient who started the administration 8 months after the onset, being the earliest among the 5 patients. her ebv-dna leve ... | 2015 | 26111530 |
| positive expression of programmed death ligand-1 correlates with superior outcomes and might be a therapeutic target in primary pulmonary lymphoepithelioma-like carcinoma. | primary pulmonary lymphoepithelioma-like carcinoma (lelc) is a rare subtype of non-small cell lung cancer (nsclc), and no effective treatments have been defined for advanced disease. programmed cell death-ligand 1 (pd-l1) is expressed in a group of cancers that may be suitable targets for specific immunotherapy. | 2015 | 26109869 |
| impaired epstein-barr virus-specific neutralizing antibody response during acute infectious mononucleosis is coincident with global b-cell dysfunction. | here we present evidence for previously unappreciated b-cell immune dysregulation during acute epstein-barr virus (ebv)-associated infectious mononucleosis (im). longitudinal analyses revealed that patients with acute im have undetectable ebv-specific neutralizing antibodies and gp350-specific b-cell responses, which were associated with a significant reduction in memory b cells and no evidence of circulating antibody-secreting cells. these observations correlate with dysregulation of tumor necr ... | 2015 | 26109734 |
| epstein-barr virus-specific cd8(+) t lymphocytes from diffuse large b cell lymphoma patients are functionally impaired. | epstein-barr virus (ebv) is a persistent virus with oncogenic capacity that has been implicated in the development of aggressive b cell lymphomas, primarily in immunosuppressed individuals, although it can be present in immunocompetent individuals. changes in the function and clonal diversity of t lymphocytes might be implied by viral persistence and lymphoma development. the aim of the present study was to evaluate the frequency, phenotype, function and clonotypical distribution of ebv-specific ... | 2015 | 26174440 |
| isolation, production and characterization of fully human monoclonal antibodies directed to plasmodium falciparum msp10. | semi-immunity against the malaria parasite is defined by a protection against clinical episodes of malaria and is partially mediated by a repertoire of inhibitory antibodies directed against the blood stage of plasmodium falciparum, in particular against surface proteins of merozoites, the invasive form of the parasite. such antibodies may be used for preventive or therapeutic treatment of p. falciparum malaria. here, the isolation and characterization of novel human monoclonal antibodies (humab ... | 2015 | 26174014 |
| immune and epstein-barr virus gene expression in cerebrospinal fluid and peripheral blood mononuclear cells from patients with relapsing-remitting multiple sclerosis. | gene expression analyses in paired cerebrospinal fluid (csf) and peripheral blood mononuclear cells (pbmc) from patients with multiple sclerosis (ms) are restrained by the low rna amounts from csf cells and low expression levels of certain genes. here, we applied a taqman-based pre-amplification real-time reverse-transcription polymerase chain reaction (rt-pcr) (preamp rt-pcr) to cdna from csf cells and pbmc of ms patients and analyzed multiple genes related to immune system function and genes e ... | 2015 | 26169064 |
| extranodal nk/t cell lymphoma and aggressive nk cell leukaemia: evidence for their origin on cd56+bright cd16-/+dim nk cells. | mature natural killer (nk) cell neoplasms are classified by the world health organization into extranodal nk/t cell lymphoma, nasal type (enktl) and aggressive nk cell leukaemia (ankl). in order to propose their normal nk cell counterparts, we reviewed the literature on the phenotype of the neoplastic nk cells from five series of patients with enktl (n = 411) and seven series of patients with ankl (n = 114) and compared with that of the normal and activated mature cd56 nk cell subsets. the tumou ... | 2015 | 26166665 |
| ultrasonographic gallbladder abnormality of primary epstein-barr virus infection in children and its influence on clinical outcome. | the incidence of pediatric acute inflammatory gallbladder (gb) disease without gallstone such as acute acalculous cholecystitis has increased with the development of improved diagnostic modalities. although epstein-barr virus (ebv) infection is common in general population, only few cases of gb diseases caused by ebv infection have been reported. this study analyzed ultrasonographic characteristics of primary ebv infection in children and evaluated the influence of ebv-associated gb disease on c ... | 2015 | 26166109 |
| evaluation of risk factors for nasopharyngeal carcinoma in a high-risk area of india, the northeastern region. | northeastern india is a major nasopharyngeal carcinoma (npc) high risk-area although the rest of the country has very low incidence. a case-control study of 105 npc cases and 115 controls was conducted to identify the potential risk factors for npc development in this region. information was collected by interviewer about socio-demographic characteristics, cigarette smoking, alcohol consumption, dietary history, occupational history, and a family history of cancer. epstein-barr viral load was as ... | 2015 | 26163617 |
| antigen-specific t cell therapies for cancer. | adoptively transferred antigen-specific t cells that recognize tumor antigens through their native receptors have many potential benefits as treatment for virus-associated diseases and malignancies, due to their ability to selectively recognize tumor antigens, expand and persist to provide long-term protection. infusions of t cells targeting epstein-barr virus (ebv) antigens have shown encouraging response rates in patients with post-transplant lymphoproliferative disease as well as ebv-positive ... | 2015 | 26160910 |
| [association between multiple sclerosis or neuromyelitis optica and epstein-barr virus]. | accumulated evidence shows an association between epstein-barr viral (ebv) infection and multiple sclerosis (ms). in particular, ebv infections before the onset of ms, particularly in childhood, is associated with the pathogenesis of ms. meanwhile, the association between neuromyelitis optica (nmo) and infectious agents has been reported, but is currently unclear. recently we studied the association between nmo and ebv and compared between ms and ebv. the results showed that ms is associated wit ... | 2015 | 26160816 |
| epstein-barr virus bzlf1 protein impairs accumulation of host dna damage proteins at damage sites in response to dna damage. | epstein-barr virus (ebv) infection is closely associated with several human malignancies including nasopharyngeal carcinoma (npc). the ebv immediate-early protein bzlf1 is the key mediator that switches ebv infection from latent to lytic forms. the lytic form of ebv infection has been implicated in human carcinogenesis but its molecular mechanisms remain unclear. bzlf1 has been shown to be a binding partner of several dna damage response (ddr) proteins. its functions in host ddr remain unknown. ... | 2015 | 26006018 |
| programmed death-1 (pd-1), programmed death-ligand 1 (pd-l1), and ebv-encoded rna (eber) expression in hodgkin lymphoma. | programmed death-1 (pd-1) and programmed death-ligand 1 (pd-l1) are new targets in cancer immunotherapy. pd-1 protein is an immune checkpoint expressed in many tumors. epstein-barr virus (ebv) is present in malignant hodgkin/reed-sternberg (hrs) cells in approximately 40-50 % of hodgkin lymphoma (hl). the aim of this study is to evaluate the clinical and prognostic importance of pd-1 and/or pd-l1 in hl and also to determine the association between ebv-encoded rna (eber) and pd-1/pd-l1. formalin- ... | 2015 | 26004934 |
| isotypes of epstein-barr virus antibodies in rheumatoid arthritis: association with rheumatoid factors and citrulline-dependent antibodies. | in order to study the humoral immune response against epstein-barr virus (ebv) in patients with rheumatoid arthritis (ra) and to compare it with the two major autoantibody types in ra, plasma samples from 77 ra patients, 28 patients with systemic lupus erythematosus (sle), and 28 healthy controls (hcs) were investigated by enzyme-linked immunosorbent assays (elisa). increased percentages of positives and concentrations of igg/iga/igm antibodies against the latent ebv nuclear antigen-1 (ebna-1) w ... | 2015 | 26000294 |
| ebv-positive large b-cell lymphomas in young patients: a nodal lymphoma with evidence for a tolerogenic immune environment. | few studies have reported epstein-barr virus-positive (ebv(+)) large b-cell lymphomas (lbcls) in young patients without immunodeficiency. we identified 46 such cases in patients ≤45 years of age and analyzed the clinical and pathological characteristics. ebv(+) lbcls affected predominantly males (male:female = 3.6:1), with a median age of 23 years (range, 4-45 years). all patients presented with lymphadenopathy and 11% also had extranodal disease. morphologically, 3 patterns were identified: t-c ... | 2015 | 25999451 |
| the clinical utility of plasma epstein-barr virus dna assays in nasopharyngeal carcinoma: the dawn of a new era?: a systematic review and meta-analysis of 7836 cases. | in this study, we assessed the potential of plasma epstein-barr virus (ebv) dna assays to predict clinical outcomes in a large sample of nasopharyngeal carcinoma (npc) patients and proposed a risk stratification model based on standardized ebv dna load monitoring.we conducted a meta-analysis of 14 prospective and retrospective comparative studies (n = 7 836 patients) to evaluate the correlation between pretreatment plasma ebv dna (pre-dna), midtreatment plasma ebv dna (mid-dna), posttreatment pl ... | 2015 | 25997061 |
| epstein-barr virus infection and gastric cancer: a systematic review. | epstein-barr virus (ebv) infection is found in a subset of gastric cancers. previous reviews have exclusively focused on ebv-encoded small rna (eber) positivity in gastric cancer tissues, but a comprehensive evaluation of other type of studies is lacking.we searched the pubmed database up to september, 2014, and performed a systematic review.we considered studies comparing ebv nucleic acids positivity in gastric cancer tissue with positivity in either adjacent non-tumor tissue of cancer patients ... | 2015 | 25997049 |
| traf1 coordinates polyubiquitin signaling to enhance epstein-barr virus lmp1-mediated growth and survival pathway activation. | the epstein-barr virus (ebv) encoded oncoprotein latent membrane protein 1 (lmp1) signals through two c-terminal tail domains to drive cell growth, survival and transformation. the lmp1 membrane-proximal tes1/ctar1 domain recruits trafs to activate map kinase, non-canonical and canonical nf-kb pathways, and is critical for ebv-mediated b-cell transformation. traf1 is amongst the most highly tes1-induced target genes and is abundantly expressed in ebv-associated lymphoproliferative disorders. we ... | 2015 | 25996949 |
| gammaherpesvirus co-infection with malaria suppresses anti-parasitic humoral immunity. | immunity to non-cerebral severe malaria is estimated to occur within 1-2 infections in areas of endemic transmission for plasmodium falciparum. yet, nearly 20% of infected children die annually as a result of severe malaria. multiple risk factors are postulated to exacerbate malarial disease, one being co-infections with other pathogens. children living in sub-saharan africa are seropositive for epstein barr virus (ebv) by the age of 6 months. this timing overlaps with the waning of protective m ... | 2015 | 25996913 |
| spontaneous post-transplant disorders in nod.cg- prkdcscid il2rgtm1sug/jictac (nog) mice engrafted with patient-derived metastatic melanomas. | patient-derived tumor xenograft (pdtx) approach is nowadays considered a reliable preclinical model to study in vivo cancer biology and therapeutic response. nod scid and il2rg-deficient mice represent the "gold standard" host for the generation of pdtxs. compared to other immunocompromised murine lines, these mice offers several advantages including higher engraftment rate, longer lifespan and improved morphological and molecular preservation of patient-derived neoplasms. here we describe a spe ... | 2015 | 25996609 |
| primary hepatic leiomyoma: unusual cause of an intrahepatic mass. | leiomyomas are benign lesions arising from the smooth muscle layer. they are most commonly detected either within the gastrointestinal or genitourinary tracts. primary hepatic leiomyoma (phl) is a rare pathology. it is an isolated pathology within the liver, without evidence of any other coexisting leiomyomas. very few cases have been described in literature. phl may occur in healthy individuals although an association with immunodeficiency and epstein-barr virus (ebv) infection has been observe ... | 2015 | 25992372 |
| impact of the environment on multiple sclerosis. | epidemiological studies suggest that environmental factors play a significant role in the development of multiple sclerosis. this article presents current knowledge on the impact of the environment on disease risk and disease course. | 2015 | 25991624 |
| autoantibody signatures combined with epstein-barr virus capsid antigen-iga as a biomarker panel for the detection of nasopharyngeal carcinoma. | nasopharyngeal carcinoma (npc) is prevalent in southern china and southeast asia, and autoantibody signatures may improve early detection of npc. in this study, serum levels of autoantibodies against a panel of six tumor-associated antigens (p53, ny-eso-1, mmp-7, hsp70, prx vi, and bmi-1) and epstein-barr virus capsid antigen-iga (vca-iga) were tested by enzyme-linked immunosorbent assay in a training set (220 npc patients and 150 controls) and validated in a validation set (90 npc patients and ... | 2015 | 25990085 |
| hepatoid carcinoma of the pancreas with lymphoid stroma: first description of the clinical, morphological, immunohistochemical, and molecular characteristics of an unusual pancreatic carcinoma. | we report a case of tumour in the head of the pancreas observed in a 57-year-old man with a history of worsening jaundice and elevated alpha-fetoprotein (afp) serum level, who underwent whipple pancreatoduodenectomy. histologically, the tumour was predominantly composed of solid sheets of large eosinophilic cells with a prominent lymphoid infiltration without association neither with dna microsatellite instability nor epstein-barr virus infection. the tumour was diffusely and strongly positive f ... | 2015 | 25989715 |
| rapamycin ameliorates the ctla4-ig-mediated defect in cd8(+) t cell immunity during gammaherpesvirus infection. | latent viral infections are a major concern among immunosuppressed transplant patients. during clinical trials with belatacept, a ctla4-ig fusion protein, patients showed an increased risk of epstein-barr virus-associated posttransplant lymphoproliferative disorder, thought to be due to a deficient primary cd8(+) t cell response to the virus. using a murine model of latent viral infection, we observed that rapamycin treatment alone led to a significant increase in virus-specific cd8(+) t cells, ... | 2015 | 25989700 |
| clinicopathological findings of chronic rejection in a face grafted patient. | skin chronic rejection (cr) in vascularized composite allotransplantation has not been included in the banff classification yet. we report a face-transplant patient who developed cutaneous clinicopathologic changes suggestive of cr. | 2015 | 25989498 |
| the impact of ebv status on characteristics and outcomes of posttransplantation lymphoproliferative disorder. | we examined the associations of epstein-barr virus (ebv) status with characteristics and outcomes of posttransplantation lymphoproliferative disorder (ptld) by studying 176 adult solid organ transplant recipients diagnosed with ptld between 1990 and 2013 (58 [33%] ebv-negative; 118 [67%] ebv-positive). the proportion of ebv-negative cases increased over time from 10% (1990-1995) to 48% (2008-2013) (p < 0.001). ebv-negative ptld had distinct characteristics (monomorphic histology, longer latency) ... | 2015 | 25988622 |
| severe leptospirosis complicated by epstein-barr virus reactivation. | weil's disease is a severe, potentially fatal illness following leptospira interrogans infection. the reported case of a patient suffering from acute renal failure, jaundice, thrombocytopenia, rhabdomyolysis and encephalitis syndrome highlights the clinical challenge in reference to weil syndrome complicated by epstein-barr virus (ebv) reactivation. | 2015 | 25987479 |
| breast milk as a potential source of epstein-barr virus transmission among infants living in a malaria-endemic region of kenya. | we previously reported that infants in kenya were infected with epstein-barr virus (ebv) at <6 months of age, suggesting that mothers were the likely source of transmissible virus to the infant. in this study, we investigated whether breast milk contained infectious ebv and the role of malaria in ebv shedding in breast milk. | 2015 | 25985902 |
| human gammaherpesviruses viraemia in hiv infected patients. | the epstein-barr virus (ebv) and kaposi's sarcoma associated herpesvirus (kshv) are consistently associated with lymphoproliferative diseases and cancers in humans, notably in patients with hiv. | 2015 | 25979989 |
| multiple sclerosis. | multiple sclerosis (ms) is a chronic, debilitating disease that can have devastating effects. presentation varies widely in symptoms, pace, and progression. in addition to a thorough history and physical examination, diagnostic tools required to diagnose ms and exclude other diagnoses include mri, evoked potential testing, and cerebrospinal fluid analysis. although the disease is not curable presently, quality of life can be improved by minimizing the frequency and severity of disease burden. di ... | 2015 | 25979578 |
| nasopharyngeal carcinoma. | nasopharyngeal carcinoma is uncommon in the united states, with only 0.2 to 0.5 cases per 100,00 people; this is in contrast to southern china and hong kong, where the incidence is 25 to 50 per 100,000 people. there is a potential link between epstein-barr virus and the development of nasopharyngeal carcinoma. radiotherapy alone as a single modality leads to similar 10-year survival rates in united states, denmark, and hong kong (34%, 37%, and 43%, respectively). multiple studies have shown an a ... | 2015 | 25979399 |
| evidence for viral infection as a causative factor of human biliary atresia. | to explore the evidence for viral infections triggering human biliary atresia (ba) by reviewing archival original articles that analyzed human samples via polymerase chain reaction (pcr) experiments, considering the recent experimental trend of extensive use of rotaviral ba animal models. | 2015 | 25979202 |
| development of a time-resolved fluoroimmunoassay for epstein-barr virus viral capsid antigen iga antibody in human serum. | viral capsid antigen (vca) iga is one of the most commonly tested antibodies for epstein-barr virus (ebv) in the clinic and is a proven biomarker to predict the risk of nasopharyngeal carcinoma (npc) and other diseases. at present, a vca-iga antibody is used for clinical diagnosis by enzyme-linked immunosorbent assay (elisa), which can detect samples only qualitatively or semi-quantitatively, with unsatisfactory sensitivity and specificity. in this study, an indirect time-resolved fluoroimmunoas ... | 2015 | 25977184 |
| epigenetic changes in neurology: dna methylation in multiple sclerosis. | epigenetics is defined as the study of the mechanisms that regulate gene expression without altering the underlying dna sequence. the best known is dna methylation. multiple sclerosis (ms) is a disease with no entirely known etiology, in which it is stated that the involvement of environmental factors on people with a genetic predisposition, may be key to the development of the disease. it is at this intersection between genetic predisposition and environmental factors where dna methylation may ... | 2015 | 25976949 |
| ebv+ diffuse large b-cell lymphoma arising within atrial myxoma in chinese immunocompetent patient. | the incidence rate of primary cardiac lymphoma is very low. primary cardiac lymphoma within myxoma is extremely rare disease. so far, these cases have been reported only eight in the world, which has not reported in chinese so far. hence, we reported the unique chinese case of 52-year-old immunocompetent male with primary epstein-barr virus positive diffuse large b-cell lymphoma arising within atrial myxoma, and had no evidence of systemic lymphoma. the patient presented right sided body numbnes ... | 2015 | 25973119 |
| epstein-barr virus-positive multiple myeloma developing after immunosuppressant therapy for rheumatoid arthritis: a case report and review of literature. | a 61-year-old woman was diagnosed as having rheumatoid arthritis (ra) and began treatment with salazosulfapyridine (sasp) and methotrexate (mtx) in 2008; the administration of concomitant tacrolimus (tac) was initiated in 2010. she subsequently developed concurrent multiple myeloma (mm), immunoglobulin g (igg)-κ type, in 2012. a portion of the tumor cells tested positive for epstein-barr virus-encoded small rna (eber). mtx treatment was discontinued in 2014, and the exacerbation of mm ensued. th ... | 2015 | 25973110 |
| aberrant epstein-barr virus antibody patterns and chronic lymphocytic leukemia in a spanish multicentric case-control study. | epstein-barr virus (ebv)-related malignancies harbour distinct serological responses to ebv antigens. we hypothesized that ebv serological patterns can be useful to identify different stages of chronic lymphocytic leukemia. | 2015 | 25972916 |
| regulation of dna damage signaling and cell death responses by epstein-barr virus latent membrane protein 1 (lmp1) and lmp2a in nasopharyngeal carcinoma cells. | nasopharyngeal carcinoma (npc) is closely associated with latent epstein-barr virus (ebv) infection. although ebv infection of preneoplastic epithelial cells is not immortalizing, ebv can modulate oncogenic and cell death mechanisms. the viral latent membrane proteins 1 (lmp1) and lmp2a are consistently expressed in npc and can cooperate in bitransgenic mice expressed from the keratin-14 promoter to enhance carcinoma development in an epithelial chemical carcinogenesis model. in this study, lmp1 ... | 2015 | 25972552 |
| an unusual presentation of cardiac tamponade associated with epstein-barr virus infection. | we present a case of an 80-year-old woman who presented with a dry cough, shortness of breath and general malaise. she had presented 5 days previously with a sore throat, feeling feverish and with non-specific symptoms. her background included paroxysmal atrial fibrillation and hypertension. she was initially thought to have decompensated heart failure secondary to atrial fibrillation and was initiated on diuretic therapy. however, a transthoracic echocardiogram performed revealed collapse of th ... | 2015 | 25972381 |
| the ebna-2 n-terminal transactivation domain folds into a dimeric structure required for target gene activation. | epstein-barr virus (ebv) is a γ-herpesvirus that may cause infectious mononucleosis in young adults. in addition, epidemiological and molecular evidence links ebv to the pathogenesis of lymphoid and epithelial malignancies. ebv has the unique ability to transform resting b cells into permanently proliferating, latently infected lymphoblastoid cell lines. epstein-barr virus nuclear antigen 2 (ebna-2) is a key regulator of viral and cellular gene expression for this transformation process. the n-t ... | 2015 | 26024477 |
| epstein barr virus-positive mucocutaneous ulcer of the colon associated hodgkin lymphoma in crohn's disease. | epstein barr virus (ebv) positive mucocutaneous ulcers (ebvmcu) form part of a spectrum of ebv-associated lymphoproliferative disease. they have been reported in the setting of immunosenescence and iatrogenic immunosuppression, affecting the oropharyngeal mucosa, skin and gastrointestinal tract (git). case reports and series to date suggest a benign natural history responding to conservative management, particularly in the git. we report an unusual case of ebvmcu in the colon, arising in the set ... | 2015 | 26019475 |
| cross talk between ebv and telomerase: the role of tert and notch2 in the switch of latent/lytic cycle of the virus. | epstein-barr virus (ebv)-associated malignancies, as well as lymphoblastoid cell lines (lcls), obtained in vitro by ebv infection of b cells, express latent viral proteins and maintain their ability to grow indefinitely through inappropriate activation of telomere-specific reverse transcriptase (tert), the catalytic component of telomerase. our previous studies demonstrated that high levels of tert expression in lcls prevent the activation of ebv lytic cycle, which is instead triggered by tert s ... | 2015 | 26018735 |
| epstein-barr virus-related post-transplant lymphoproliferative disorder in the skin. | 2015 | 26017499 | |
| long-term outcome of extranodal nk/t cell lymphoma patients treated with postremission therapy using ebv lmp1 and lmp2a-specific ctls. | extranodal nk/t-cell lymphoma (enktcl) is associated with latent epstein-barr virus (ebv) infection and frequent relapse even after complete response (cr) to intensive chemotherapy and radiotherapy. the expression of ebv proteins in the tumor provides targets for adoptive immunotherapy with antigen-specific cytotoxic t cells (ctl). to evaluate the efficacy and safety of ebv latent membrane protein (lmp)-1 and lmp-2a-specific ctls (lmp1/2a ctls) stimulated with lmp1/2a rna-transferred dendritic c ... | 2015 | 26017177 |