Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| [pancreatic disease in patients with hiv treated with didanosine (ddi)]. | pancreatic involvement has been studied in 70 hiv infected patients, in diverse stages, that were treated with didanosine (ddi), both as monotherapy or associated to zidovudine; 38% of patients presented adverse reaction that obliged to withdraw the medication: pancreatitis (4%), hyperamylasemia (21%) and abdominal pain and/or diarrhea (12%). the possible causes in presentation of adverse effects were evaluated: route of infection, stage of hiv infection, use of pentamidine or trimethoprim-sulfa ... | 1996 | 8664067 |
| role of il-12 in peripheral blood mononuclear cell responses to fungi in persons with and without hiv infection. | clinical trials of il-12 in persons infected with hiv have been proposed based on recent evidence suggesting il-12 plays a critical role in the development of protective immune responses, and the hiv infection is associated with a deficiency of il-12. as fungal infections are among the most common opportunistic infections associated with aids, we examined whether il-12 p40 gene expression and p70 release in response to cryptococcus neoformans and candida albicans were deficient in monocyte-enric ... | 1996 | 8666825 |
| pneumonia in cats caused by pneumocystis carinii purified from mouse lungs. | fourteen mice trapped in or near houses were infected with pneumocystis carinii and the establishment of pneumonia was helped by injecting with cortisone acetate for 6 weeks. then 16 cats were infected with p. carinii by injection of lung homogenate from the mice which contained from 1.3 x 10(5) to 2.6 x 10(5) p. carinii cysts. the infection resulted in severe cough and tachypnea in cats 1-8 injected with cortisone acetate, and a subclinical infection in cats 9-16. in cats 1-8, the main patholog ... | 1996 | 8750695 |
| spontaneous pneumothorax in the aids population. | spontaneous pneumothorax (sp) in patients with acquired immunodeficiency syndrome (aids) has become the leading cause of nontraumatic pneumothorax in the urban population. however, the appropriate treatment, especially the role of surgical intervention, remains controversial. a retrospective study of 33 patients with aids who were treated for 38 episodes of sps (5 bilateral sps) at our institution was conducted. the study consisted of 25 males (76%) and 8 females (24%) with a mean age of 38 year ... | 1996 | 8751768 |
| pneumothorax as the presenting sign of pneumocystis carinii infection in an hiv-positive child with prior lymphocytic interstitial pneumonitis. | an hiv-positive child presented with a pneumothorax secondary to cavitary pneumocystis carinii pneumonia (pcp). lymphocytic interstitial pneumonitis had been evident on earlier radiographs but had resolved, concurrent with a decrease in her cd4 counts, before the radiographic changes of pcp became evident. as immune function declines in hiv-positive children, the chest radiograph may paradoxically clear. in such a setting, development of focal lung disease, including pneumothorax, may herald pne ... | 1996 | 8753672 |
| naturally acquired pneumocystis carinii pneumonia in gene disruption mutant mice: roles of distinct t-cell populations in infection. | when kept under strict specific-pathogen-free conditions, h-21-abeta (abeta(-/-),t-cell receptor beta (tcrbeta(-/-)), and recombinase-activating gene 1 (rag-1(-/-) gene disruption mutant mice, deficient in conventional cd4+ t cells, tcralphabeta cells, and all peripheral t and b lymphocytes, respectively, consistently developed lethal pneumocystis carinii pneumonia through natural infection. the most severe symptoms appeared in rag-1(-/-) mutants. in contrast, tcrdelta(-/-) and beta2-microglobul ... | 1996 | 8757854 |
| the first one hundred aids cases in hong kong. | to study the clinical and epidemiological characteristics of the first 100 reported aids cases in hong kong. | 1996 | 8758375 |
| madin darby canine kidney: a new cell line for pneumocystis carinii in vitro culture. | pneumocystis carinii pneumonia (pcp) is a highly frequent cause of morbidity and mortality in immunocompromised subjects, particularly in hiv-infected ones. the biology of p. carinii is poorly understood because of the lack of reliable synthetic media or adequate cell lines to grow this opportunistic pathogen in continuous culture. we reported the suitability of the mdck (madin darby canine kidney, attc ccl 34) cell line to support the temporary microorganism's growth in vitro and the experiment ... | 1996 | 8758555 |
| lack of activity of artemether for prophylaxis and treatment of toxoplasma gondii and pneumocystis carinii infections in rat. | artemisinin and its derivatives have been found effective in vivo against plasmodium and in vitro against toxoplasma gondii and pneumocystis carinii. we tested the activity of artemether for prophylaxis and treatment in the rat model of concurrent t. gondii and p. carinii infection. artemether at doses of 18 and 100 mg/kg administered (s.c.) in prophylaxis did not prevent toxoplasmosis or pneumocystosis, while trimethoprimsulfamethoxazole (reference treatment) was effective for prevention of bot ... | 1996 | 8758556 |
| cd4 and total lymphocyte counts as predictors of hiv disease progression. | cd4+ t-lymphocyte (cd4) counts are a standard laboratory marker of disease progression in hiv infection, but expense precludes their use in large parts of the world. total lymphocyte counts (tlc), in contrast, are widely available. we compared cd4 and tlc counts as predictors of developing aids or death in 831 hiv-positive out-patients (582 males and 249 females with both homosexual (males, n = 316) and heterosexual (n = 515) transmission patterns. the first cd4 count < 200/microliter and first ... | 1996 | 8759490 |
| aerobic bacteria, chlamydia trachomatis, pneumocystis carinii and cytomegalovirus as agents of severe pneumonia in small infants. | the authors studied 58 infants hospitalized for pneumonia in a semi-intensive care unit. age ranged from 1 complete to 6 incomplete months. the infants were sent from another hospital in 20 cases and from home in a further 38. pulmonary involvement, which was alveolar in 46 cases and interstitial in 12, was bilateral in 31 children. the investigation was carried out prospectively on the etiological agents associated with respiratory infection to look for evidence of aerobic bacteria (blood cultu ... | 1996 | 8762633 |
| employment of terbinafine against pneumocystis carinii infection in rat models. | the anti-pneumocystis carinii response of terbinafine together with that of three other compounds, trimethoprim sulphamethoxazole (tmp-smx), atovaquone (atq) and albendazole (alb), has been investigated in immunosuppressed sprague-dawley rats with established pneumocystosis. drugs were administered orally (terbinafine in dosages of 40 and 80 mg/kg per day, tmp 12.5 mg/kg per day plus smx 62.5 mg/kg per day, atq 100 mg/kg per day and alb 600 mg/kg per day) to six rat groups except one which serve ... | 1996 | 8763466 |
| synthesis of tumor necrosis factor-alpha mrna in bronchoalveolar lavage cells from human immunodeficiency virus-infected persons with pneumocystis carinii pneumonia. | bronchoalveolar lavage fluid cells from a cohort of 34 human immunodeficiency virus-infected persons with established pneumocystis carinii pneumonia were examined for expression of tumor necrosis factors (tnf-alpha) mrna by fluorescence in situ hybridization with an antisense riboprobe. video image analysis was used to develop a quantitative assay that evaluates relative single-cell levels of mrna. the resulting data were analyzed as an antisense-to-sense ratio and examined for correlation betwe ... | 1996 | 8769632 |
| diversity of host species and strains of pneumocystis carinii is based on rrna sequences. | we have amplified by pcr pneumocystis carinii cytoplasmic small-subunit rrna (variously referred to as 16s-like or 18s-like rrna) genes from dna extracted from bronchoalveolar lavage and induced sputum specimens from patients positive for p. carinii and from infected ferret lung tissue. the amplification products were cloned into puc18, and individual clones were sequenced. comparison of the determined sequences with each other and with published rat and partial human p.carinii small-subunit rrn ... | 1996 | 8770515 |
| rapid microscopic detection of cytomegalovirus and pcp in bronchoalveolar lavage specimens. | this article describes how bronchoalveolar lavage specimens can be screened rapidly and inexpensively for pneumocystis carinii and cytomegalovirus infections with materials available in any hospital laboratory. | 1996 | 8772406 |
| five year leukaemia-free survival of 72% and 77% for early stage acute and chronic myeloid leukaemia treated by hla-identical sibling bone marrow transplantation. | hla-identical sibling bone marrow transplantation is an accepted treatment for patients with acute myeloid leukaemia (aml) and chronic myeloid leukaemia (cml). we have recently reported improving results in hla-identical sibling transplant over the ten year period 1981-1990. in this report we described the outcome in patients transplanted at st vincent's hospital, sydney between 1989 and 1993. | 1996 | 8775529 |
| severe community-acquired pneumonia. | severe community-acquired pneumonia is a distinct clinical entity usually requiring intensive care unit (icu) management. among community-acquired pneumonia (cap) requiring hospital admission, approximately 10% will receive icu care and the mortality rate ranges from 21% to 47%. host-related factors, clinical presentation, laboratory and radiographic findings on admission are useful in identifing the patient at high risk for fulminant pneumonia. the most common organisms responsible for severe c ... | 1996 | 8776779 |
| severe pulmonary infections in aids patients. | pulmonary infections are a very common complication in acquired immune deficiency syndrome (aids) patients. these infections may be severe enough to initiate the admission of these patients to intensive care units (icu). pneumocystis carinii pneumonia (pcp) is the most frequent cause of icu admission because of acute respiratory failure. mortality of icu-admitted patients with this infection has changed with time. initial reports confirmed a high mortality (80% to 90%). after 1985, the mortality ... | 1996 | 8776781 |
| immunopathogenesis and spectrum of infections in systemic lupus erythematosus. | this study reviews the pertinent immunopathologic mechanisms that contribute to increased susceptibility to infection in patients with systemic lupus erythematosus (sle) and the spectrum of infections in patients with sle. it assesses the impact on patient care, morbidity, and mortality. | 1996 | 8778988 |
| incidence of pneumocystis carinii pneumonia after renal transplantation. impact of immunosuppression. | the incidence and potential risk factors of pneumocystis carinii pneumonia (pcp) in our population of renal transplant recipients were analyzed retrospectively. of 1427 patients who received transplants between january 1986 and june 1994, 1192 were evaluated. four different immunosuppressive regimens were applied: (1) cyclosporine (csa) + prednisolone (pred), (2) csa + azathioprine (aza, 2 mg/kg/day) + pred, (3) csa + aza + antithymocyte globulin, and (4) (after december 1, 1993, european multic ... | 1996 | 8779695 |
| [pancytopenia and pneumocystis carinii pneumonia associated with low dose methotrexate pulse therapy for rheumatoid arthritis--case report and review of literature]. | low-dose weekly pulse mtx therapy is effective for rheumatoid arthritis (ra) and is used for patients with ra who are unresponsive to conventional disease-modifying antirheumatic drugs (dmards). we used mtx to a 62-year-old man with ra who had received dmards for 5 years. mtx was effective for ra but after 12 weeks mtx therapy started, he complicated pancytopenia and developed pneumocystis carinii pneumonia. we reviewed all ra patients reported in japan and in the world from 1965, complicated wi ... | 1996 | 8779792 |
| molecular biology and epidemiology of pneumocystis carinii infection in aids. | 1996 | 8780810 | |
| the role of t cells in infection-driven interstitial pneumonia after bone marrow transplantation in mice. | over the course of five weeks, there were no significant histopathological changes in the lungs of mice given either allogeneic or syngeneic bone marrow transplants (bmt) with whole body irradiation (wbi). however, all mice that received both wbi and pneumocystis carinii inoculation developed a more protracted and severe interstitial pneumonia than that of normal mice given p carinii. this pneumonia was exacerbated by allogeneic bmt but was ameliorated by syngeneic bmt. the interstitial pneumoni ... | 1996 | 8781619 |
| rejection treatment and cytomegalovirus infection as risk factors for pneumocystis carinii pneumonia in renal transplant recipients. | pneumocystis carinii pneumonia (pcp) is an infection of immunocompromised patients. the purpose of our study was to estimate the risk of pcp in renal transplant recipients in relation to number, timing, and type of rejection treatments and to cytomegalovirus (cmv) infection. in a case-control study, 15 renal transplant recipients with proven pcp were compared with 95 controls. the relative risks of pcp for 1, 2, and > or = 3 rejection treatments vs. no such treatment were 1.7 (95% ci, 0.2-12.5), ... | 1996 | 8783687 |
| granulomatous pneumocystis carinii pneumonia in patients with low-grade lymphoid malignancies: a diagnostic dilemma. | 1996 | 8783726 | |
| identification of extrapulmonary pneumocystis carinii in immunocompromised rats by pcr. | pneumocystis carinii has been shown to cause extra-alveolar infections in humans, but the lack of a reproducible animal model has hindered the elucidation of mechanisms of p. carinii dissemination. in the present study, pcr and the immunosuppressed rat model were used to gain further insight into the dissemination of p. carinii organisms in extrapulmonary (ep) tissues. primer sequences specific to major surface glycoprotein (msg) and dihydrofolate reductase (dhfr) were used to detect p. carinii ... | 1996 | 8784565 |
| dna sequences identical to pneumocystis carinii f. sp. carinii and pneumocystis carinii f. sp. hominis in samples of air spora. | samples of ambient air collected with three different types of spore traps in a rural location were examined for the presence of pneumocystis carinii by screening for p. carinii-specific dna sequences by dna amplification. eleven spore trap samples were analyzed by nested pcr, using oligonucleotide primers designed for the gene encoding the mitochondrial large subunit rrna of p. carinii f. sp. carinii and p. carinii f. sp. hominis. the samples were collected over a 3-year period during the month ... | 1996 | 8784583 |
| preventing pneumocystis carinii pneumonia in human immunodeficiency virus-infected children: new guidelines for prophylaxis. cdc, us public health service, and the infectious disease society of america. | 1996 | 8822291 | |
| alternative dapsone dosage regimen for prophylaxis of pneumocystis carinii pneumonia. | 1996 | 8822303 | |
| influence of pneumocystis carinii on nitrite production by rat alveolar macrophages. | nitrite production by rat alveolar macrophages was studied to determine the role of l-arginine oxidation in the interaction between these cells and pneumocystis carinii. alveolar macrophages from rats obtained from two different breeders were used: rats from janvier breeder had latent p. carinii infection, while those from charles river breeder were bred in a germ-free environment. pneumocystis carinii increased in vitro nitrite generation by unstimulated alveolar macrophages from janvier rats o ... | 1996 | 8822811 |
| cloning of the s-adenosylhomocysteine hydrolase gene of pneumocystis carinii. | 1996 | 8822814 | |
| reliable one-tube nested pcr for detection and sscp-typing of pneumocystis carinii. | 1996 | 8822815 | |
| antigenic variation by telomeric recombination of major-surface-glycoprotein genes of pneumocystis carinii. | 1996 | 8822816 | |
| evaluation of pcr technique for diagnosing pneumocystis carinii pneumonia in hiv positive patients using oropharyngeal washings. | 1996 | 8822817 | |
| antibody responses to pneumocystis carinii in hospital personal with and without exposure to patients with p. carinii pneumonia. | 1996 | 8822818 | |
| identification of a cell division cycle (cdc2) homologue in pneumocystis carinii. | 1996 | 8822819 | |
| the role of alveolar macrophages in pneumocystis carinii elimination from the lower respiratory tract. | 1996 | 8822820 | |
| pneumocystis carinii modulates cyclin-dependant kinase activity in a lung epithelial cell line. | 1996 | 8822821 | |
| pneumocystis carinii glycoprotein a stimulates interleukin-8 production and inflammatory cell activation in alveolar macrophages and cultured monocytes. | 1996 | 8822823 | |
| detection of pneumocystis carinii dna in hiv patients with p. carinii pneumonia (pcp) and in animal models. | 1996 | 8822824 | |
| comparison of two pcr methods for detection of pneumocystis carinii in bronchoalveolar lavage fluid. | 1996 | 8822825 | |
| microwave processing of pneumocystis carinii for electron microscopy. | 1996 | 8822826 | |
| high infectivity of pneumocystis carinii cultivated on l2 rat alveolar epithelial cells. | 1996 | 8822827 | |
| role of alveolar macrophages during the spontaneous pneumocystis carinii pneumonia of rabbit at weaning. | 1996 | 8822828 | |
| genetic divergence at the mitochondrial small subunit ribosomal rna gene among isolates of pneumocystis carinii from five mammalian host species. | 1996 | 8822829 | |
| manganese-cofactored superoxide dismutase activity in rat-derived pneumocystis carinii. | 1996 | 8822830 | |
| in vitro decrease of rat-derived pneumocystis carinii attachment induced by human natural yeast killer toxin-like antiidiotypic candidacidal antibodies. | 1996 | 8822831 | |
| pneumocystis carinii detection in 158 hiv-seronegative patients. | 1996 | 8822832 | |
| inhibitory effect of a pichia anomala killer toxin on the viability of rat-derived pneumocystis carinii. | 1996 | 8822833 | |
| western blot analysis of rat pneumocystis carinii antigens using convalescent rat sera and rabbit anti-gp120. | 1996 | 8822834 | |
| expression of the major surface glycoprotein of rat-derived pneumocystis carinii by recombinant baculovirus. | 1996 | 8822835 | |
| development of a molecular typing method for pneumocystis carinii sp.f. hominis. | 1996 | 8822837 | |
| survival and infectivity of pneumocystis carinii outside the mammalian host. | air blower prefilters servicing hepa-filtered biobubble housing pneumocystis carinii-infected rats were stored for up to five months at -80 degrees c to room temperature. after storage, 76% of immunosuppressed rats exposed to these prefilters developed p. carinii infections. in contrast, only 4% of control immunosuppressed rats exposed to autoclaved filters had p. carinii infections. these observations indicate that the organism has a dormant form that remains infective for at least several mont ... | 1996 | 8822838 |
| identification of c31 and c32 sterols in pneumocystis carinii hominis-infected human lungs. | two sterols in autopsied whole lung specimens obtained from pneumocystis carinii pneumonia patients were detected by gas-liquid chromatography and their structures were elucidated by mass spectrometry and nuclear magnetic resonance spectrometry. both were in the lanosterol series; the c31 sterol, with a methyl group at c-24, was identified as euphorbol, and the more abundant c32 sterol, with an ethyl group at c-24, is given the trivial name pneumocysterol. | 1996 | 8822839 |
| prevalence of various pneumocystis carinii sp. f. hominis types in different geographical locations. | 1996 | 8822840 | |
| upregulation of host mitochondrial atpase 6 gene in pneumocystis carinii-infected rat lungs. | 1996 | 8822841 | |
| sulfa resistance in mouse-derived pneumocystis carinii. | 1996 | 8822842 | |
| evaluation of sulfa drugs against recombinant pneumocystis carinii dihydropteroate synthetase and in vivo. | 1996 | 8822843 | |
| diagnosis of pcp by itss nested pcr on notinvasive oropharingeal samples. | pneumocystis carinii pneumonia is an opportunistic disease usually affecting immunocompromised hosts. diagnosis is based on the microscopical detection of microrganism on bal, an invasive sample which requires pt compliance for collection and skilled health care personnel for examination. in order to verify the possible diagnostic utility of noninvasive specimens collected in the upper respiratory tract we examined by the internal transcribed spacers (itss) nested pcr, 39 oropharingeal samples ( ... | 1996 | 8822844 |
| p.carinii dna detected by itss nested pcr in serum and pbmc of aids patients with pcp. | pneumocystis carinii pneumonia (pcp) is usually diagnosed by examination of bal, a sample often unpleasant to be collected from immunocompromised host affected by acute respiratory disease. we studied by the internal transcribed spacers (itss) nested pcr the presence of p.carinii dna in serum and peripheral blood mononuclear cells (pbmc) during acute episodes of pcp to test blood as a possible noninvasive diagnostic tool. | 1996 | 8822845 |
| types of pneumocystis carinii detected in air samples. | 1996 | 8822847 | |
| demonstration of esterase activity in pneumocystis carinii by cleavage of 4-methylumbelliferyl substrates. | 1996 | 8822848 | |
| kinetics of 2 genetically distinct pneumocystis carinii populations in rat colonies. | the natural history of prototype and variant pneumocystis carinii populations in several colonies of rats were monitored over time periods ranging from 1 to 4 years. karyotypic profiles of organism populations from individual rats were evaluated for the proportion of prototype:variant p. carinii and the number of animals harboring co-infections were enumerated. throughout the observation periods: (1) each p. carinii population retained its distinctive karyotype; (2) the proportions of prototype: ... | 1996 | 8822849 |
| pneumocystis carinii pneumonia in four mammal species: histopathology and ultrastructure. | 1996 | 8822850 | |
| stability of four genetic loci in pneumocystis carinii sp. f. carinii. | 1996 | 8822851 | |
| multi-locus genotype switching in pneumocystis carinii sp. f. hominis: evidence for reinfection. | 1996 | 8822852 | |
| detailed analyses of individual neutral lipid classes of pneumocystis. | individual neutral lipid classes of pneumocystis carinii carinii were isolated and purified by thin-layer chromatography. the fatty acids in steryl esters, triglycerides, free fatty acids, diglycerides, and monoglycerides were quantified by gas-liquid chromatography. the fatty acid compositions of these lipids were similar to those of the neutral lipid classes in whole rat lung controls, unlike comparable studies of phospholipid classes. the free fatty alcohols of rat lung controls and p. carini ... | 1996 | 8822853 |
| clinically achievable plasma deferoxamine concentrations eliminate pneumocystis carinii trophozoites in a rat model. | 1996 | 8822854 | |
| subpopulations of pneumocystis carinii separated by a percoll gradient. | 1996 | 8822855 | |
| biodiversity of french and italian human pneumocystis carinii. | 1996 | 8822856 | |
| usefulness of molecular biology for pneumocystis carinii hominis pneumonia epidemiology. | 1996 | 8822857 | |
| pneumocystis carinii pneumonia: evolution from 1981 to 1995 in two paris hospitals. | 1996 | 8822858 | |
| fludarabine monophosphate as salvage for refractory chronic lymphocytic leukaemia. | to assess the efficacy of the purine analogue fludarabine monophosphate (famp) as salvage therapy in patients at groote schuur hospital with chronic lymphocytic leukaemia (cll) refractory to standard therapy. | 1996 | 8823419 |
| risk factors for pneumocystis carinii pneumonia in patients with polymyositis/dermatomyositis or systemic lupus erythematosus. | to investigate risk factors for pneumocystis carinii pneumonia (pcp) in patients with systemic lupus erythematosus (sle) and polymyositis/dermatomyositis (pm/dm). | 1996 | 8823690 |
| women and hiv infection. | the pattern of the aids epidemic has recently changed with proportionately more women and children affected. cases are becoming more widespread and heterosexual encounters are becoming an important means of spread of disease (presently 43% of all cases in the united states). risks of contracting the virus depend upon sexual behaviors and the status of hiv disease in her partner. manifestations of hiv infection are varied in women and include infections and cancer. once the patient tests positive ... | 1996 | 8824089 |
| primary and secondary prophylaxis for pneumocystis carinii related complications in hiv patients. | 1996 | 8793444 | |
| effect of long-term primary aerosolized pentamidine prophylaxis on breakthrough pneumocystis carinii pneumonia. | aerosolized pentamide is a well-tolerated primary prophylaxis regimen for pneumocystis carinii pneumonia (pcp) in human immunodeficiency virus (hiv)-infected patients. it is now commonly administered for prolonged periods. we therefore studied the effect of long-term inhalation on breakthrough pcp. we recorded clinical, immunological, radiological and microbiological data, as well as therapy and clinical course of all episodes with confirmed pcp diagnosed at our institution between january 1, 19 ... | 1996 | 8793464 |
| complementary therapies in hiv disease. | this study was designed to determine whether a standardized program of complementary therapies combined with appropriate standard medical care would have a measurable influence on the course of hiv disease when compared with data from other groups. all 10 participants began this study in 1988 with a diagnosis of asymptomatic hiv-positive. they received a 1-month orientation to the program and were then seen at 3-month intervals for follow-up data collection. data were compared with two groups th ... | 1996 | 8795921 |
| [a case of aids with intractable cryptococcal meningitis]. | a 38-year-old hemophiliac, who had been infected with hiv by the administration of blood products and had been diagnosed as aids by the onset of pneumocystis carinii pneumonia, was admitted to our hospital with the complaints of headache and vomiting. after he was diagnosed as cryptococcal meningitis using the microscopy, cryptococcal antigen detection and culture of cerebrospinal fluid, treatment with amphotericin-b and fluconazole was started. as there was no clinical improvement, spinal drain ... | 1996 | 8797310 |
| autopsy patterns of disease among subgroups of an inner-city bronx aids population. | the bronx, new york, has a large, inner-city, aids population which contains a greater proportion of women and intravenous drug users and a lower percentage of homosexuals than the u.s. aids population overall. because this population is reflective of the evolving trends in the national aids population, our objective was to gain an understanding of patterns of infections, malignancies, and cause of death among these individuals. all autopsies (252) performed on patients with aids at two hospital ... | 1996 | 8797686 |
| aids-associated non-hodgkin's lymphomas as primary and secondary aids diagnoses in hemophiliacs. hemophilia malignancy study group. | we studied the characteristics and temporal trends of aids- associated non-hodgkin's lymphoma (aids-nhl) in individuals with hemophilia. prospective data were collected on 33 hiv-positive hemophiliacs with aids-nhl enrolled in the hemophilia malignancy study (hms), of whom 21 had primary and 12 had secondary or subsequent aids-defining illnesses, and analyzed for frequency and temporal trends. as compared with primary aids- nhl, secondary aids-nhl occurred at an older mean age, 37 versus 29 year ... | 1996 | 8797689 |
| non specific pcr products using rat-derived pneumocystis carinii dihydrofolate reductase gene-specific primers in dna amplification of human respiratory samples. | dna amplification using dihydrofolate reductase (dhfr) primers in bronchoalveolar lavage fluids (balfs) from patients with pneumocystis carinii (pc) pneumonia yielded low sensitivity and specificity. amplified products of balfs from an aids patient without pc pneumonia and five patients with pc pneumonia were cloned and sequenced. all samples showed the same sequence without any homology with dhfr cdna of rat pc, or with any dhfr sequences in databases at the dna or amino acid level. the data de ... | 1996 | 8799372 |
| clinical features of aids in the edinburgh city hospital cohort. | in order to describe the clinical features of aids, particularly injection drug use (idu) related aids in patients attending the regional infectious diseases unit in edinburgh a prospective review of the 680 hiv-positive patients, 30% of whom were women and 68% were infected via idu was undertaken. the commonest aids-related clinical problem in edinburgh was pneumocystis carinii pneumonia (pcp). whilst gender differences were not apparent in terms of clinical problems, differences were observed ... | 1996 | 8799781 |
| [changes in the spectrum of aids-defining diseases in spain]. | since the late 1980s the use of prophylaxis against several aids-diagnostic diseases has been recommended. in order to detect the impact of these measures we analyzed the shifts in the spectrum of aids-diagnostic diseases in spain. | 1996 | 8801384 |
| unique telomeric expression site of major-surface-glycoprotein genes of pneumocystis carinii. | major cell surface glycoproteins (msg) of pneumocystis carinii play a crucial role in the host-parasite interactions involved in p. carinii pneumonia in aids patients. genes encoding msgs are repeated, highly polymorphic, and distributed among all of the 14-15 chromosomes. here we show, by bal-31 exonuclease cleavage and dna cloning experiments, that the unique expression site (previously termed ucs) of msg genes located in the 500-kb chromosome is telomeric. the 11-kb genomic ucs fragment isola ... | 1996 | 8804856 |
| new model of oropharyngeal and gastrointestinal colonization by candida albicans in cd4+ t-cell-deficient mice for evaluation of antifungal agents. | a new model for the evaluation of antifungal compounds against oropharyngeal and gastrointestinal mucosal colonization by candida albicans was developed. to simulate the immune deficiency observed in aids patients, mice were depleted of cd4+ t lymphocytes by the injection of either gk1.5 hybridoma cells or purified anti-cd4+ t lymphocytes by the injection of either gk1.5 hybridoma cells or purified anti-cd4+ monoclonal antibody derived from gk1.5 hybridoma cells in tissue culture. fluorescence-a ... | 1996 | 8807048 |
| late onset pneumocystis carinii pneumonia following allogeneic bone marrow transplantation. | we retrospectively reviewed all positive pneumocystis carinii findings among adult patients who had received an allogeneic bm transplant at the helsinki university central hospital between july 1990 and december 1993. the aim was to define the incidence of late onset pneumocystis carinii pneumonia (pcp) in bmt patients who had routinely received pcp prophylaxis for 6 months post-bmt. in 110 bmt patients, 16 episodes of pcp were documented. only one patient had been receiving pcp prophylaxis at t ... | 1996 | 8807114 |
| physical and social correlates of perceived psychological support among hospitalized aids patients. | persons living with hiv disease are faced with a broad array of physical and psychosocial problems across the trajectory of their illness. almost all will be hospitalized for nursing care during the course of their disease. the purpose of this study was to explore the physical health and social correlates of perceived psychological support among hospitalized aids patients. the sample consisted of 168 aids patients hospitalized with pneumocystis carinii pneumonia (pcp). each patient rated his or ... | 1996 | 8807393 |
| [sulfamethoxazole-trimethoprim-induced pneumonitis in a patient with hemophilia b who was infected with the human immunodeficiency virus]. | severe cellular immunosuppression developed in a 25-year-old man with hemophilia b who was infected with the human immunodeficiency virus (hiv). four days after administration of sulfamethoxazole-trimethoprim (smx-tmp) for prophylaxis against pneumocystis carinii pneumonia (pcp), diffuse uptake of both lungs was confirmed on a 67ga scintigram. reticular shadows were also seen throughout both lung fields on a chest ct scan. these findings were compatible with pcp, according to the guidelines for ... | 1996 | 8810766 |
| detection of pneumocystis carinii with direct fluorescence antibody and calcofluor white stain. | direct fluorescence monoclonal antibody stain (dfa) was compared prospectively, with calcofluor white (cfw) stain for the diagnosis of pneumocystis carinii in 163 respiratory specimens from 97 patients. the patient population included persons with hiv infection (58%), bone marrow transplant recipients (10%), immunosuppressed patients owing to chemotherapy (21%) and others (11%). nineteen specimens including 12 sputa, six bronchoalveolar lavage fluids (bals) and one induced sputum were positive b ... | 1996 | 8811365 |
| use of natural surfactant in an hiv-infected infant with pneumocystis carinii pneumonia. | 1996 | 8814483 | |
| pleural pseudotumoral mass revealing an extrapulmonary pneumocystis carinii infection. | 1996 | 8816165 | |
| pneumocystis carinii pneumonia in rheumatoid arthritis patients treated with methotrexate. a report of two cases. | use of methotrexate to treat rheumatoid arthritis is associated with pulmonary adverse effects in 3% to 5% of cases. in addition to immunoallergic lung disease, bronchitis and pneumonia due to pyogenic organisms, opportunistic lower respiratory tract infections have been reported, including, to our knowledge, 18 cases of pneumocystis carinii pneumonia. we report two new cases of p. carinii pneumonia in methotrexate-treated rheumatoid arthritis patients. one case occurred in a 62-year-old woman w ... | 1996 | 8817757 |
| pneumocystis carinii infection: current treatment and prevention. | pneumocystis carinii is a common cause of pneumonia in individuals who are immunosuppressed by hiv infection. use of molecular biological techniques show that p. carinii is a fungus and that infection in man is not a zoonosis. invasive tests such as sputum induction or bronchoscopy are used to make the diagnosis of p. carinii pneumonia. life long primary prophylaxis is given to hiv positive individuals with cd4+ lymphocyte counts < 0.20 x 10(9)/l or a cd4: total lymphocyte ratio of < 1.5, consti ... | 1996 | 8818828 |
| treatment of fungal infection in aids. | fungal infections affect virtually all patients with the acquired immunodeficiency syndrome (aids). superficial infection (seborrheic dermatitis, tinea capitis, tinea corporis and tinea cruris) is more common than in the general population and can be difficult to eradicate. mucosal disease (oropharyngeal, oesophageal and vaginal candidosis) is very common and often recurs. in advanced aids, patients usually fail to respond to topical therapy and often to systemic therapy and isolates of candida ... | 1996 | 8818831 |
| detection of pneumocystis carinii dna in sputum and bronchoalveolar lavage samples by polymerase chain reaction. | 1996 | 8818916 | |
| lung abscess in patients with aids. | we identified 31 patients with human immunodeficiency virus (hiv) infection and lung abscess. all patients had advanced hiv disease, and the mean cd4 cell count was 17/mm3 (range, 2-50/mm3). twenty-two patients (71%) had previous opportunistic infections, and 24 (77%) had previous pulmonary infections. symptoms at the time of presentation included fever (90% of patients), cough (87%), dyspnea (35%), pleuritic chest pain (26%), and hemoptysis (10%). the microbiological etiology was established fo ... | 1996 | 8824970 |
| inhibitory effect of a pichia anomala killer toxin on pneumocystis carinii infectivity to the scid mouse. | a pichia anomala killer toxin has been demonstrated to have a specific inhibitory effect on the in vitro attachment of pneumocystis carinii. the results presented herein show that this yeast toxin is also effective against p. carinii infectivity in reducing parasite colonization in the lungs of scid mice. the specificity of this inhibitory effect was controlled using a monoclonal antibody neutralizing the killer properties of the yeast toxin. | 1996 | 8825204 |
| glycoprotein a is the immunodominant antigen of pneumocystis carinii in mice following immunization. | a rapid and simple dual enzyme-linked immunosorbent assay was developed to quantitate the relative frequency of monoclonal antibodies produced against pneumocystis carinii glycoprotein a (gpa) or other antigens of p. carinii after immunization with whole organisms. in balb/cj mice, p. carinii gpa was clearly the immunodominant antigen, with a quarter of all hybridomas secreting antibody directed against this molecule. | 1996 | 8825453 |
| pneumocystis carinii telomere repeats are composed of ttaggg and the subtelomeric sequence contains a gene encoding the major surface glycoprotein. | we have cloned a telomere and adjacent sequences from rat-derived pneumocystis carinii using the ability of foreign telomeres to complement a yeast artificial chromosome (yac) deficient by one telomere in saccharomyces cerevisiae. characterization of the cloned dna in the recombinant yac demonstrated that it was a chimera of two p. carinii sequences, namely a 13.5 kb fragment of mitochondrial dna and an 8.3 kb distal portion consisting of subtelomeric dna. the p. carinii telomere repeat was demo ... | 1996 | 8825773 |