Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| molecular epidemic survey on co-prevalence of scrub typhus and marine typhus in yuxi city, yunnan province of china. | human rickettsioses are worldwide zoonoses and it is not easy to differentiate them from other infectious diseases because of their atypical manifestation. in recent years the number of patients with fever of unknown causes from hongta district cdc, yuxi city of yunnan province has been increasing significantly in the summer. diagnosis of scrub typhus was made by local clinicians. in order to ascertain the disease, we undertook a laboratory investigation for such patients from august 18 to 26, 2 ... | 2007 | 17711736 |
| q fever cases in the northern territory of australia from 1991 to 2006. | q fever (infection with coxiella burnetii) has been uncommon in australia's northern territory, with no reported cases until 2002. since then, twelve cases of q fever have been reported, representing a much lower notification rate than in surrounding australian states. three cases were identified in central australia during 2006, prompting this review of clinical and epidemiological features of all notified northern territory cases. three patients required intensive care admission, 1 died, 5 had ... | 2007 | 17724999 |
| q fever in us military returning from iraq. | 2007 | 17765028 | |
| evidence for the classification of a crayfish pathogen as a member of the genus coxiella. | the study aimed to provide characterization of a potential new species of coxiella, identified following a series of outbreaks of disease in australian native freshwater crayfish. | 2007 | 17908227 |
| coxiella burnetii: host and bacterial responses to infection. | designation as a category b biothreat agent has propelled coxiella burnetii from a relatively obscure, underappreciated, "niche" microorganism on the periphery of bacteriology, to one of possibly great consequence if actually used in acts of bioterrorism. advances in the study of this microorganism proceeded slowly, primarily because of the difficulty in studying this obligate intracellular pathogen that must be manipulated under biosafety level-3 conditions. the dogged determination of past and ... | 2007 | 17825460 |
| [infrarenal aortic pseudo-aneurism due to coxiella burnetii]. | peripheral vascular expressions of coxiella burnetti q fever are not well known. endocarditis with negative blood culture is the most frequent clinical presentation of chronic q fever. to date, very few cases of aneurisms or vascular grafts infections have been described. we report the case of a 54-year-old man who presented an infrarenal abdominal aorta infection, leading to a giant pseudo aneurismal formation. blood serology and polymerase chain reaction amplification identified c. burnetti fr ... | 2007 | 17851006 |
| q fever (coxiella burnetii) among man and farm animals in north sinai, egypt. | antibodies against coxiella burnetii were estimated among sheep, goats and camels (190), their owners (150 patients with pyrexia of unknown origin) and 30 normal individuals in north sinai over the 2006 by indirect immounofluorescence assay. nested polymerase chain reaction was used to detect com-1 gene (genetic target of c. burnetii) encoding a 27-kda outer membrane protein in the samples. c. burnetii ifa antibodies (igm & igg) in patients were 8 (5.3%) and a healthy control (3.3%). the overall ... | 2007 | 17580573 |
| pathogenic rickettsiae as bioterrorism agents. | because of their unique biological characteristics, such as environmental stability, small size, aerosol transmission, persistence in infected hosts, low infectious dose, and high associated morbidity and mortality, rickettsia prowazekii and coxiella burnetii have been weaponized. these biological attributes would make the pathogenic rickettsiae desirable bioterrorism agents. however, production of highly purified, virulent, weapon-quality rickettsiae is a daunting task that requires expertise a ... | 2007 | 17582570 |
| [seroepidemiology of coxiella burnetii infection among blood donors in albacete]. | the objectives of this study were to determine the prevalence of antibodies to coxiella burnetii among blood donors and to examine the epidemiological characteristics of c. burnetii infection in albacete, spain. | 2007 | 17583651 |
| coxiella burnetii and acute exacerbations/infections in patients with chronic lung disease. | the aim of the present study was to determine the incidence of q fever in patients with an acute exacerbation of a chronic lower respiratory tract infection. eighty patients treated for acute exacerbation of chronic lower respiratory tract infections during a 30-month period were studied. q fever was diagnosed by elisa. two elderly woman with pre-existing bronchiectasis (2.5%) were diagnosed as having an acute infection by coxiella burnetii. the acute illness was considered to be a result of mix ... | 2007 | 17587435 |
| lounging in a lysosome: the intracellular lifestyle of coxiella burnetii. | most intracellular parasites employ sophisticated mechanisms to direct biogenesis of a vacuolar replicative niche that circumvents default maturation through the endolysosomal cascade. however, this is not the case of the q fever bacterium, coxiella burnetii. this hardy, obligate intracellular pathogen has evolved to not only survive, but to thrive, in the harshest of intracellular compartments: the phagolysosome. following internalization, the nascent coxiella phagosome ultimately develops into ... | 2007 | 17381428 |
| comparative diagnostic potential of three serological tests for abortive q fever in goat herds. | performances of an elisa, an immunofluorescence assay (ifa) and a complement fixation test (cft) were assessed for detecting antibodies against coxiella burnetii after q fever abortions in naturally infected goats. the goal of the study was to provide information useful for veterinary serodiagnosis in regard to categories of goats either experiencing q fever abortion or not, blood sampling times and recommended cut-offs. the study was conducted on eight goat herds with evidence of c. burnetii ab ... | 2007 | 17532581 |
| assessing the within-herd prevalence of coxiella burnetii milk-shedder cows using a real-time pcr applied to bulk tank milk. | thirty-seven bulk tank milk (btm) and individual milk samples of all contributing cows were tested for coxiella burnetii detection by a real-time pcr assay and used to assess the relationship between the btm pcr-response and (i) the within-herd prevalence of milk-shedder cows and (ii) the proportion of heavy milk-shedder cows. the within-herd prevalence of milk-shedder cows (i) was found to be significantly higher in herds with a positive btm and (ii) increased significantly with the estimated t ... | 2007 | 17542961 |
| strain and phase identification of the u.s. category b agent coxiella burnetii by matrix assisted laser desorption/ionization time-of-flight mass spectrometry and multivariate pattern recognition. | accurate bacterial identification is important in diagnosing disease and in microbial forensics. coxiella burnetii, a highly infective microorganism causative of the human disease q fever, is now considered a u.s. category b potential bioterrorism agent. we report here an approach for the confirmatory identification of c. burnetii at the strain level which involves the combined use of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (maldi-tof ms) and supervised patte ... | 2007 | 17386522 |
| community-acquired pneumonia: aetiologic changes in a limited geographic area. an 11-year prospective study. | the aim of this study is to describe the changes in the aetiology of hospitalised patients with community-acquired pneumonia (cap) during an 11-year observational period in a limited geographic area. eight hundred and one (801) adult patients with cap hospitalised were included. the patients were divided into three groups according to the time of presentation. comprehensive microbiological laboratory tests were performed and differences in aetiology were analysed. in 228 patients (31%), a pathog ... | 2007 | 17554569 |
| prevalence of coxiella burnetii dna in vaginal and uterine samples from healthy cats of north-central colorado. | q fever is a worldwide zoonotic disease caused by coxiella burnetii. although traditionally associated with livestock exposure, human infection has also been documented from contact with parturient cats. the goal of this study was to determine the prevalence of c burnetii dna in uterine and vaginal tissues from healthy client-owned and shelter cats of north-central colorado using polymerase chain reaction assay. coxiella burnetii was not amplified from vaginal samples of any cat or uterine biops ... | 2007 | 17208030 |
| coxiella burnetii infection of an aortic graft with multiple vertebral body erosion. | q fever is caused by coxiella burnetii and often has an insidious clinical presentation. we describe a rare case of q fever infection of an aortic graft presenting with pyrexia and constant severe midlumbar pain due to erosion of multiple vertebral bodies. after successful treatment with graft resection and extra-anatomic vascular reconstruction, the patient continues on lifelong antibiotic therapy. we also present regional q fever epidemiologic data together with a review of all previously docu ... | 2007 | 17264024 |
| case records of the massachusetts general hospital. case 5-2007. a 53-year-old man with a prosthetic aortic valve and recent onset of fatigue, dyspnea, weight loss, and sweats. | 2007 | 17301303 | |
| the response regulator pmra is a major regulator of the icm/dot type iv secretion system in legionella pneumophila and coxiella burnetii. | legionella pneumophila and coxiella burnetii have been shown to utilize the icm/dot type iv secretion system for pathogenesis and recently a large number of icm/dot-translocated substrates were identified in l. pneumophila. bioinformatic analysis has revealed that 13 of the genes encoding for l. pneumophila-translocated substrates and five of the c. burnetii icm/dot genes, contain a conserved regulatory element that resembles the target sequence of the pmra response regulator. experimental analy ... | 2007 | 17302824 |
| ambient generation of fatty acid methyl ester ions from bacterial whole cells by direct analysis in real time (dart) mass spectrometry. | direct analysis in real time (dart) is implemented on a time-of-flight (tof) mass spectrometer, and used for the generation of fatty acid methyl esters (fames) ions from whole bacterial cells. | 2007 | 17308638 |
| detection of pathogens in ovine and caprine abortion samples from sardinia, italy, by pcr. | during 2003-2005, 399 abortion samples (315 fetuses and 84 placentae) were collected from 107 ovine and caprine farms in northern sardinia. tissues from aborted fetuses and placentae were examined by pcr assay to detect dna from coxiella burnetii, chlamydophila abortus, salmonella enterica serovar abortusovis, toxoplasma gondii, and neospora caninum. the dna from at least 1 of these 5 infectious agents was amplified in 41% of ovine fetuses, while only 17% of the caprine fetuses yielded a positiv ... | 2007 | 17459840 |
| q fever: the long journey to control by vaccination. | 2007 | 17309414 | |
| [q fever: still many unanswered questions]. | 2007 | 17335693 | |
| [outbreak of coxiella burnetii pneumonia]. | the aim of this study was to describe an outbreak of q fever pneumonia in the north of spain. | 2007 | 17335697 |
| [q fever]. | 2007 | 17491389 | |
| q fever in logroño: an attack scenario. | bioterrorism has emerged as an important infectious disease and public health challenge in the 21st century, and issues of preparedness and response are now prominent. the development of attack scenarios for assessing this problem contributes to the organization of response systems and identifies aspects that may need to be improved. the authors present an attack scenario involving q fever in a specific area, the city of logroño, spain. the evolution of the outbreak is described and the attempts ... | 2007 | 17335700 |
| [q fever in extremadura: an emerging infection]. | q fever (coxiella burnetii infection) is an underdiagnosed zoonosis in our area, extremadura, a rural region in the southwest of spain. the characteristics of q fever and the changes in this infection seen over the last decade in our hospital are described. | 2007 | 17386216 |
| controlled trial of a 5-day course of telithromycin versus doxycycline for treatment of mild to moderate scrub typhus. | new antibiotics are required to have the antibacterial activity against doxycycline-resistant orientia tsutsugamushi. an in vitro sensitivity study showed that telithromycin was more effective than erythromycin for rickettsia, bartonella, and coxiella burnetii. in this prospective, open-label, randomized trial, we enrolled patients with mild-to-moderate scrub typhus. we compared the efficacy and safety of a 5-day telithromycin therapy with those of a 5-day doxycycline therapy at chosun universit ... | 2007 | 17404000 |
| analysis of the o-antigen biosynthesis regions of phase ii isolates of coxiella burnetii. | the o-antigen-encoding region in the genomes of 14 isolates of coxiella burnetii was examined by pcr. five phase i isolates (nine mile clone 7, kav, ohio, henzerling rsa 343, q173) were analyzed and no deletions were detected. two other isolates of unknown phase (scottish, wav) were examined, but no deletions were detected. in contrast, rsa 514 and three phase ii isolates (nine mile phase ii clone 4, nine mile phase ii clone 1, nine mile baca) contained large deletions, and the latter two were f ... | 2007 | 17156123 |
| vanin-1 controls granuloma formation and macrophage polarization in coxiella burnetii infection. | q fever is caused by coxiella burnetii, a bacterium that survives in mphi. vanin-1 is a membrane-anchored pantetheinase that controls tissue inflammation. consequently, vanin-1-deficient mice represent a unique mouse model in which stress-induced inflammation is limited by the reaction of resident tissue cells. to investigate the contribution of host tissues in the control of a bacterial infection, we infected vanin-1-deficient mice with c. burnetii. mortality and morbidity of mice were not affe ... | 2007 | 17163446 |
| role of sex, age, previous valve lesion, and pregnancy in the clinical expression and outcome of q fever after a large outbreak. | q fever is a zoonosis caused by coxiella burnetii. after a large outbreak occurred in the chamonix valley in the french alps in 2002, an extensive surveillance was conducted, to describe the variations in the clinical expression of acute q fever according to host factors, as well as to monitor the risk of evolution of acute q fever to chronic q fever in patients at risk. | 2007 | 17173223 |
| q fever. | an outbreak of q fever occurred in scotland during this summer and was reported in news headlines. despite these newsworthy headlines, q fever remains poorly understood. the causative organism, coxiella burnetii, has a worldwide distribution, with the notable exception of new zealand. even with its ubiquitous nature, q fever is rarely reported. we explore some of the underlying reasons for this apparent under diagnosis together with some of the diagnostic challenges posed by this obligate intrac ... | 2007 | 17147957 |
| goats may experience reproductive failures and shed coxiella burnetii at two successive parturitions after a q fever infection. | q fever is a zoonosis caused by the obligate intracellular bacterium, coxiella burnetii. aborting domestic ruminants are the main source of human infection. in january 2003, an abortion episode occurred in a dairy caprine herd where 18/60 (30%) goats experienced reproductive problems: 4/60 (7%) aborted and 14/60 (23%) had stillbirths. serological screening for abortion-related infectious diseases suggested q fever. the diagnosis of c. burnetii infection was confirmed with pcr based on the occurr ... | 2007 | 17187835 |
| psoas abscess: an unusual manifestation of q fever. | q fever may lead to serious complications in chronically infected patients. we report two cases of psoas abscess due to coxiella burnetii associated with lumbar osteomyelitis secondary to an aortic aneurysmal infection. diagnosis was based on serology, and pcr detected c. burnetii dna in an abscess sample. | 2007 | 17223046 |
| rickettsial pathogens in the tropical rat mite ornithonyssus bacoti (acari: macronyssidae) from egyptian rats (rattus spp.). | we collected and tested 616 tropical rat mites (ornithonyssus bacoti (hirst)) from rats (rattus norvegicus (berkenhout) and r. rattus (linnaeus)) throughout 14 governorates in egypt and tested dna extracts from pools of these mites for bartonella spp., coxiella burnetii, and rickettsia spp. by pcr amplification and sequencing. three different mite-associated bacterial agents, including one bartonella and two rickettsia spp., were detected in eight pools of mites. further research could demonstra ... | 2007 | 17225079 |
| computer-aided diagnosis with potential application to rapid detection of disease outbreaks. | our objectives are to quickly interpret symptoms of emergency patients to identify likely syndromes and to improve population-wide disease outbreak detection. we constructed a database of 248 syndromes, each syndrome having an estimated probability of producing any of 85 symptoms, with some two-way, three-way, and five-way probabilities reflecting correlations among symptoms. using these multi-way probabilities in conjunction with an iterative proportional fitting algorithm allows estimation of ... | 2007 | 17225213 |
| the autophagic pathway is actively modulated by phase ii coxiella burnetii to efficiently replicate in the host cell. | the etiologic agent of q fever coxiella burnetii, is an intracellular obligate parasite that develops large vacuoles with phagolysosomal characteristics, containing multiple replicating bacteria. we have previously shown that phase ii c. burnetii replicative vacuoles generated after 24-48 h post infection are decorated with the autophagic protein lc3. the aim of the present study was to examine, at earlier stages of infection, the distribution and roles of the small gtpases rab5 and rab7, marker ... | 2007 | 17087732 |
| [fever of intermediate duration after return from the canary islands]. | a 35 year old patient presented to the emergency room with high fever, headache and a maculopapular rash after returning from the canary islands. elevated levels of ldh and transaminases and thrombopenia developed during the further hospital course. this presentation is common for an infection with rickettsia typhi. therapy with doxycycline is usually effective and should be instituted promptly. the patient's fever remitted 48 h after the first dose. fever of intermediate duration has been descr ... | 2007 | 17308911 |
| proteome and antigen profiling of coxiella burnetii developmental forms. | a biphasic developmental cycle whereby highly resistant small-cell variants (scvs) are generated from large-cell variants (lcvs) is considered fundamental to the virulence of coxiella burnetii, the causative agent of human q fever. in this study a proteome analysis of c. burnetii developmental forms was conducted to provide insight into their unique biological and immunological properties. silver-stained gels of scv and lcv lysates separated by two-dimensional (2-d) gel electrophoresis resolved ... | 2007 | 17088354 |
| observed prevalence of tick-borne pathogens in domestic animals in sicily, italy during 2003-2005. | the objective of this study was to characterize the observed prevalence of tick-borne pathogens (tbp) in domestic animals in sicily, italy during 2003-2005. serological (competitive elisa and indirect immunofluorescence antibody, n = 3299) and dna tests (polymerase chain reaction and reverse line blot, n = 2565) were conducted on horse, donkey, cattle, sheep, goat, pig and dog samples. pathogens analysed included anaplasma, ehrlichia, rickettsia, babesia and theileria species, and coxiella burne ... | 2007 | 17359441 |
| bartonella native valve endocarditis: the first brazilian case alive and well. | bartonella is an important cause of blood culture-negative endocarditis in recent studies. seroprevalence studies in the states of minas gerais and rio de janeiro have shown bartonella igg positivity around 14% in healthy adults and 40% in hiv seropositive adults, respectively. a case report of a 46-year-old white male with moderate aortic regurgitation (ar) due to rheumatic heart disease (rhd), admitted due to worsening heart failure, is presented. clinical features were apyrexia, anemia, polyc ... | 2007 | 18327472 |
| [drug activity against coxiella burnetii, a pathogen of q fever]. | 2007 | 18461810 | |
| [q fever]. | q fever is a zoonosis caused by coxiella burnetii. the infection is transmitted to humans mainly through aerosols generated from products of delivery of cows and other animals. generally the disease presents acutely with fever, pneumonitis and hepatitis. but chronic endocarditis is also a possible occurrence. diagnosis is usually made by serology. the acute form of the infection responds well to tetracyclines and other antibiotics. but endocarditis is difficult to treat, and its prognosis is gri ... | 2007 | 18275268 |
| acute hepatitis associated with q fever in a man in greece: a case report. | abstract: coxiella burnetii is the causative agent of q fever. q fever is a worldwide zoonosis that is responsible for various clinical manifestations. however, in greece hepatitis due to coxiella is rarely encountered. a case of q fever associated with hepatitis is reported here. diagnosis was made by specific serological investigation (enzyme-linked immunosorbent and indirect immunofluorescene assays) for coxiella burnetii. | 2007 | 18042291 |
| fever of unknown origin due to rickettsioses. | most common rickettsioses do not fill the criteria for fever of unknown origin, with fever often inferior to lasting less than 1 week. q fever, scrub typhus, murine typhus, human monocytic ehrlichiosis, and bartonellosis could fill these criteria, however, notably in uncommon presentations. moreover, in patients returning from tropical areas or from geographic endemic areas for rickettsiosis, or in patients in contact with animals or ticks, theses etiologies should be kept in mind by physicians ... | 2007 | 18061086 |
| manipulation of rab gtpase function by intracellular bacterial pathogens. | intracellular bacterial pathogens have evolved highly specialized mechanisms to enter and survive within their eukaryotic hosts. in order to do this, bacterial pathogens need to avoid host cell degradation and obtain nutrients and biosynthetic precursors, as well as evade detection by the host immune system. to create an intracellular niche that is favorable for replication, some intracellular pathogens inhibit the maturation of the phagosome or exit the endocytic pathway by modifying the identi ... | 2007 | 18063721 |
| [abortion and stillbirth among dairy goats as a consequence of coxiella burnetii]. | the clinical signs and pathological findings of clinical q fever in dairy goats in the netherlands are described. the disease is characterized by endemic or epidemic abortion in late pregnancy, stillbirth, or the birth of weak kids. these consequences of coxiella burnetii infection appear to have increased during recent years in the dutch dairy goat population. detection of the agent in placental tissue by immunohistochemistry has proven diagnostically useful. | 2007 | 18085173 |
| [q fever: an overview]. | q fever, a zoonosis caused by the gram-negative bacterium coxiella burnetii, occurs worldwide and affects both humans and animals. ruminants are considered to be the main source of infection of humans, with the main route of infection being through inhalation of the organism of fine-particle aerosols. abortion is the main clinical sign in ruminants. during and after abortion, large quantities of the bacterium are shed via the placenta and other vaginal secretions. the bacterium may also be prese ... | 2007 | 18085174 |
| mechanisms of vaccine-induced protective immunity against coxiella burnetii infection in balb/c mice. | to elucidate the mechanisms of vaccine-induced protective immunity against coxiella burnetii infection, we compared the protective efficacy and immunogenicity between formalin-inactivated phase i vaccine (pi-v) and phase ii vaccine (pii-v) in balb/c mice. pi-v generated significant protection while pii-v did not confer measurable protection. analysis of cytokine and subclass ab responses indicated that both pi-v and pii-v were able to induce a th1-dominant immune response but did not identify th ... | 2007 | 18056383 |
| is1111 insertion sequences of coxiella burnetii: characterization and use for repetitive element pcr-based differentiation of coxiella burnetii isolates. | coxiella burnetii contains the is1111 transposase which is present 20 times in the nine mile phase i (9mi/i) genome. a single pcr primer that binds to each is element, and primers specific to a region approximately 500-bp upstream of each of the 20 is1111 elements were designed. the amplified products were characterized and used to develop a repetitive element pcr genotyping method. | 2007 | 17949485 |
| persistent hepatitis and repeated wheezing in an infant. q fever. | 2007 | 17848898 | |
| comparison of coxiella burnetii shedding in milk of dairy bovine, caprine, and ovine herds. | the shedding of coxiella burnetii in bovine, caprine, and ovine milk was measured using pcr, in 3 herds for each species, the bulk tank milk samples of which were positive at the time of their selection. milk samples of 95 cows, 120 goats, and 90 ewes were sampled over 16 wk, as was the bulk tank milk. the shedding of c. burnetii in vaginal mucus and feces was checked at the beginning of the experiment and 2 mo later. the clinical signs in the selected herds as well as the duration and the shedd ... | 2007 | 18024725 |
| [an outbreak of q fever in the netherlands--possible link to goats]. | in 2007, 73 cases of q fever were identified through reports and retrospective analyses; the affected region extended from tilburg in the southwest to arnhem in the northeast. the infections arose in late spring, particularly in may and june. several spontaneous abortions due to q fever occurred on 4 dairy goat farms in the same region. the national incidence of spontaneous abortion due to q fever was 6 cases in 2006 and 7 in 2007. climatically, this southern region was extraordinarily dry durin ... | 2007 | 17953175 |
| outbreak of query fever among argentinean special police unit officers during a united nations mission in prizren, south kosovo. | after an outbreak of query fever (q fever) in an argentinean special police unit, 115 officers were investigated to evaluate the risk of infection with coxiella burnetii after having been exposed to contaminated dust originating from a nearby barn harboring infected sheep. all officers were serologically tested and the medical history of potential risk factors was performed. the percentage of officers showing acute q-fever seroconversion was found to be 51.3%. forty-two individuals showed clinic ... | 2007 | 17985775 |
| two rare severe and fulminant presentations of q fever in patients with minimal risk factors for this disease. | we described two rare severe and fulminant clinical presentations of acute q fever. the first patient had severe multiorgan failure. the second patient had fever and severe cholera-like diarrhoea. coxiella burnetii polymerase chain reaction on blood or serum can be clinically useful in the diagnosis of acute q fever before seroconversion. | 2007 | 17908089 |
| attenuated coxiella burnetii phase ii causes a febrile response in gamma interferon knockout and toll-like receptor 2 knockout mice and protects against reinfection. | coxiella burnetii is a highly infectious obligate intracellular bacterium. the phase i form is responsible for q fever, a febrile illness with flu-like symptoms that often goes undiagnosed. the attenuated c. burnetii phase ii (having a truncated "o" chain of its lipopolysaccharide) does not cause disease in immunocompetent animals; however, phase ii organisms remain infectious, and we questioned whether disease could be produced in immunodeficient mice. to study c. burnetii phase ii infections, ... | 2007 | 17893129 |
| outbreak of q fever associated with a horse-boarding ranch, colorado, 2005. | coxiella burnetii is a bacterium located worldwide that can cause q fever when inhaled. we describe an outbreak of q fever associated with a horse-boarding ranch that had acquired two herds of goats. we conducted case finding and cohort studies among persons who boarded horses on the ranch and ranchers and among residents in the surrounding community, and conducted sampling of the goats and environment, to determine risk factors for infection and guide public health interventions. sixty-six ranc ... | 2007 | 17896873 |
| q fever in migrant workers, scotland. | 2007 | 18258064 | |
| infective endocarditis with negative blood cultures. | culture-negative endocarditis is important as it has a relatively poor prognosis. the principal reason for negative cultures is prior antibiotic therapy although fastidious organisms such as bartonella spp. and coxiella burnetii are also important. pcr may offer significant advantages in diagnosis but tests require standardisation. modification of current diagnostic criteria is required. empirical cover of mrsa needs to be considered. | 2007 | 17890062 |
| serologic and molecular characterization of tickborne pathogens in lions (panthera leo) from the fasano safari park, italy. | lions (panthera leo) are an endangered species threatened by illegal hunting, habitat loss, and infectious diseases. little is known about the tick-borne pathogens that infect lions and could contribute to population declines. the objective of this study was to characterize rickettsia spp., anaplasma phagocytophilum, and coxiella burnetii infections in 10 lions from the fasano safari park in italy by serology, polymerase chain reaction, and sequence analysis. although animals did not show clinic ... | 2007 | 18229868 |
| a review of the efficacy of human q fever vaccine registered in australia. | q fever remains an important occupational zoonosis in rural australia. although q fever vaccine is recommended in high-risk occupational groups, its availability has been limited in recent years. | 2007 | 17854543 |
| polymorphisms in toll-like receptors-2 and -4 are not associated with disease manifestations in acute q fever. | coxiella burnetii is a macrophage-tropic, gram-negative organism, which causes acute q fever infection in humans. this zoonotic infection causes illness ranging from asymptomatic seroconversion to severe and protracted disease featuring hepatitis and pneumonia. interactions between c. burnetii lipopolysaccharide (lps) and host toll-like receptors (tlr)-2 and -4 have been implicated in pathogen recognition, phagocytosis and signaling responses. nonconservative single nucleotide polymorphisms in t ... | 2007 | 17855803 |
| molecular identification of major and minor bullous pemphigoid antigens. | the skin antigens defined by basement membrane zone antibodies in 38 patients with bullous pemphigoid were analyzed by western immunoblot. thirty-four patients (89%) had antibodies to a major bullous pemphigoid antigen with a molecular weight of approximately 230 kd. twelve patients (32%) had antibodies to a minor bullous pemphigoid antigen with a molecular weight of approximately 160 kd; this included four patients who did not have antibodies to the 230 kd antigen. depending on the epidermal ex ... | 2007 | 2254473 |
| molecular identification of major and minor bullous pemphigoid antigens. | the skin antigens defined by basement membrane zone antibodies in 38 patients with bullous pemphigoid were analyzed by western immunoblot. thirty-four patients (89%) had antibodies to a major bullous pemphigoid antigen with a molecular weight of approximately 230 kd. twelve patients (32%) had antibodies to a minor bullous pemphigoid antigen with a molecular weight of approximately 160 kd; this included four patients who did not have antibodies to the 230 kd antigen. depending on the epidermal ex ... | 2007 | 2254473 |
| granulocytic sarcoma of the submandibular lymph node preceding overt leukemia: significance of strict evaluation of bone marrow. | 2007 | 1951190 | |
| locus of control of behaviour: is high externality associated with substance misuse? | personal control and responsibility are key themes in the therapeutic use of 'motivational interviewing'. this popular method of counselling has suggested that clients need to believe they have a significant degree of control over their behaviour if they are to make progress. using a well validated psychological test on locus of control of behaviour, our research sought to establish whether active misusers really believed they had less personal control than non-misusers. to establish this a samp ... | 2007 | 1932882 |
| [new knowledge about the stomach and nutrition]. | 2007 | 2063589 | |
| [primary mediastinal germ cell tumors]. | the most frequent site of extragonadal germ cell tumors is the mediastinum. the majority (80%) of mediastinal germ cell tumors are benign mature teratomas, which can be easily removed. malignant germ cell tumors account for approximately 20% of all cases and are clinically classified into seminoma and non-seminomatous germ cell tumors. seminomas are radiosensitive and have relatively a good prognosis. patients with non-seminomatous germ cell tumors had a very poor prognosis, however, the introdu ... | 2007 | 2168496 |
| hypothalamo-pituitary axes and feedback control in amphibians and reptiles. | 2007 | 1974782 | |
| exaggerated natri-calci-uresis and increased circulating levels of parathyroid hormone and 1,25-dihydroxyvitamin d in patients with senile hypertension. | renal handling of na and ca in response to physiological saline infusion (20 ml/kg i.v. for 2 h) was compared between 27 hypertensive (mean +/- sd age 79.8 +/- 9.2 years) and 44 normotensive (79.1 +/- 4.1 years) senile females. compared to the normotensive group, the hypertensive group showed statistically significant decreases in the basal values of serum ca and pra, and significant increases in basal circulating levels of parathyroid hormone and 1,25(oh)2d and in urinary excretions of na, ca a ... | 2007 | 1959361 |
| pet in generalized anxiety disorder. | positron emission tomography (pet) measurements of cerebral glucose use were made in 18 patients with generalized anxiety disorder (gad) during a passive viewing task off medication, and an active vigilance viewing task before and after medication or placebo treatment. in the passive viewing task, patients with gad were compared with 15 normal controls. a significant difference in pattern of absolute brain metabolism was found. patients showed lower absolute metabolic rates in basal ganglia and ... | 2007 | 1888800 |
| extradural opioids. | 2007 | 2031827 | |
| impaired protein kinase c activation as one of the possible mechanisms of reduced lymphocyte proliferation in iron deficiency in mice. | we investigated the effects of iron deficiency in mice on protein kinase c (pkc) activation, an enzyme required for optimal lymphocyte proliferation. c57bl/6 mice were fed either an iron-deficient diet (id; 10 mg fe/kg diet), a control diet (c; 50 mg/kg diet), or were pair fed (pf) to id mice for 34 d. pkc activity was studied in spleen cells by histone phosphorylation. iron deficiency significantly reduced cytosol activity in unstimulated cells and membrane-bound activity in cells stimulated by ... | 2007 | 1951169 |
| health care providers' treatment approaches to culturally diverse infertile clients. | this study focuses on the research question of how health providers approach treatment of culturally diverse infertile clients. findings from in-depth interviews of 28 health providers in a major city in southern california revealed three types of providers: (1) culturally unaware, (2) culturally nontolerant, and 3) culturally sensitive. culturally unaware providers failed to recognize different cultural needs and treated all clients in the same way, an approach that eventually led to noncomplia ... | 2007 | 2043292 |
| compatibility of ciprofloxacin injection with selected drugs and solutions. | the compatibility of ciprofloxacin injection with selected antimicrobials and aminophylline was studied. ciprofloxacin, amikacin sulfate, aminophylline, clindamycin phosphate, gentamicin sulfate, and tobramycin sulfate were mixed separately in minibags containing 0.9% sodium chloride injection or 5% dextrose injection; admixtures were stored for up to 48 hours at either 4 degrees c or 25 degrees c. ciprofloxacin was also combined separately with each of the other drugs and solutions and stored u ... | 2007 | 1781473 |
| [the prevention of nausea and vomiting induced by antineoplastic chemotherapy: the state of the art]. | 2007 | 1853098 | |
| cost-benefit analysis of hepatitis b vaccination. | 2007 | 1824729 | |
| erythropoietin and the myelodysplastic syndrome. | 2007 | 2040188 | |
| role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin d3-induced hl-60 cell differentiation. | the treatment of hl-60 myelocytic leukemia cells with 1 alpha,25-dihydroxyvitamin d3 (1,25-(oh)2d3) resulted in the activation of a neutral sphingomyelinase and in sphingomyelin turnover (okazaki, t., bell, r., and hannun, y. (1989) j. biol. chem. 264, 19076-19080). in this paper, the effects of 1,25-(oh)2d3 on the product of sphingomyelin hydrolysis, ceramide, and the possible function of ceramide as a lipid mediator of the effects of 1,25-(oh)2d3 on hl-60 cell differentiation were investigated ... | 2007 | 2394750 |
| intrathoracic lymphadenopathy. a rare manifestation of rheumatoid pulmonary disease. | this is the first antemortem report of a patient with long-standing ra and interstitial lung disease who developed reactive mediastinal adenopathy coincident with increases in the activity of his interstitial process. mediastinal adenopathy was discovered by means of ct of the chest as part of an evaluation of interstitial lung disease. the increasing use of better imaging techniques for this purpose will undoubtedly reveal more patients with this finding. mediastinal lymphadenopathy complicatin ... | 2007 | 2323235 |
| [the prevention of the intracranial hypertension due to general anesthesia during operations on the brain]. | the article deals with the analysis of changes in cerebrospinal fluid pressure (csfp), mean arterial pressure (map), brain perfusion pressure (bpr), and central venous pressure (cvp) during general anesthesia in 172 patients with tumorous, tumor-like, and vascular diseases of the brain. csfp increased sharply during preanesthesia, in administration of inhalation anesthetics, and under the effect of inadequate anesthesia during trephination of the skull. the rise in csfp in preanesthesia can be r ... | 2007 | 2168649 |
| [biochemical liver studies of workers in ethylenediamine production]. | studies are performed on 44 workers, engaged in the production of ethylenediamine. the principle chemical noxae are: ammonia, ethylenediamine, dichloroethane, analogues of ethylenediamine, vinylchloride, sodium hydrate etc. the average concentrations of these compounds surpass the admissible norms for the air of the working environment. the biochemical studies certify for the presence of deviations in the enzymes, detoxication and lipidic liver functions. the established changes are observed in ... | 2007 | 2099467 |
| dental health education in a school system. | 2007 | 4631397 | |
| [comparative study of 5 european tables of food composition (study of european tables of food composition)]. | a comparative study has been made of the following nutritional data base: (a) c.s.i.c. (spain); (b) deutsche forschungsanstalt für lebensmittel chemie, garching; (c) inserm (france); (d) geigy; (e) wander. the following values were researched: calorie, protein, carbohydrate, fiber, calcium, iron, magnesium, vit. b1, vit b2, niacin, folic acid, vit. b12 and vit. c. in order to assess the use of these tables under different conditions, the following were researched: 1) a group of 10 essential repr ... | 2007 | 2078596 |
| sleep disruption, calorie restriction, and biological markers for depression. | 2007 | 2878241 | |
| [genetic-epidemiological studies of causes of obesity]. | parallel with biochemical and physiological research into functional disturbances possibly leading to obesity, the focus of genetic and epidemiological research has been the aetiology of obesity. there is no longer any doubt that there are both genetic and environmental causes. polygenic factors, and possibly recessive monogenic inheritance would seem to be involved. aggregation of environmental factors at the family level may be decisive so long as the family members still live together, but ot ... | 2007 | 1852591 |
| superior sagittal sinus thrombosis in blastic crisis of chronic myelogenous leukemia--a case report of a complete recovery. | literature reviews have indicated that thrombotic complications in leukemic patients are rare that prompt diagnosis is very difficult, and that morbidity and mortality are extremely high. we describe the successful treatment of a 36-year-old housewife suffering from chronic myelogenous leukemia with secondary myelofibrosis. | 2007 | 1865591 |
| [perioperative ultrasound examination of the breast in breast cancer]. | 127 cases of breast carcinoma were examined in a prospective study. by means of preoperative ultrasonography the staging following the ptnm-system validates the tumor size in 85.5% and the lymph node involvement in 77.2%. multicentric-multifocal carcinomas were diagnosed by ultrasonography in 20 of 29 cases, merely 9 of 29 by mammography. ultrasonography of specimen is recommended in cases of negative clinical findings and positive ultrasound examination to verify tumour excision. in addition to ... | 2007 | 2238972 |
| [perioperative ultrasound examination of the breast in breast cancer]. | 127 cases of breast carcinoma were examined in a prospective study. by means of preoperative ultrasonography the staging following the ptnm-system validates the tumor size in 85.5% and the lymph node involvement in 77.2%. multicentric-multifocal carcinomas were diagnosed by ultrasonography in 20 of 29 cases, merely 9 of 29 by mammography. ultrasonography of specimen is recommended in cases of negative clinical findings and positive ultrasound examination to verify tumour excision. in addition to ... | 2007 | 2238972 |
| intravascular ultrasound assessment of the renal artery. | to determine the feasibility and diagnostic value of catheter-based intravascular ultrasound imaging compared with angiography for visualizing renal artery structure. | 2007 | 1828655 |
| [sudden death syndrome in infants in their first year of life; biological maturity and borderline conditions]. | 2007 | 2075054 | |
| cerebral palsy. | epidemiology of cerebral palsy is complex, being influenced by various factors, some of which are unknown and it is commonly accompanied by other abnormalities, thus involving a variety of specialization in their treatment. in a period of 1978-1985, a retrospective study of cerebral palsy cases was performed at the child neurology subdivision department of child health school of medicine, university of sumatera/dr. pirngadi hospital, medan. there were 40 cases (1.59%) out of 2,505 new child neur ... | 2007 | 2075008 |
| obtaining and using patient data. | 2007 | 1951034 | |
| microvascular tissue transfer in paediatric patients: analysis of 106 cases. | we report a series of 106 microvascular transplants performed in paediatric patients between 1973 and 1989. eighty-eight percent of these flaps were successful. two of the 13 failed flaps (1.9%) in this series were lost because of small vessel size. otherwise, success rates (93% in the last 5 years) and complications were comparable to our adult cases. no growth-related complications were noted either in recipient or donor sites. we conclude that microvascular transplantation is a reliable proce ... | 2007 | 1933113 |
| a comparative study for fiberoptic and video endoscopic determination of the extent in minimal changes of gastric mucosa using indigo dye spraying. | the image resolution of fiberoptic and video endoscopy was compared in a series of patients with early gastric cancer. eighteen patients were divided into two groups. one group of patients (n = 9) was evaluated with fiberoptic endoscopy while the second group (n = 9) was evaluated using video endoscopy. the extent of cancer invasion, with special attention to size, shape and type of the lesions, was evaluated in each patient. attempts were also made to identify the proximal and distal limits of ... | 2007 | 2374986 |
| regulation of alcohol consumption by the renin-angiotensin system: a review of recent findings and a possible mechanism of action. | the renin-angiotensin system has traditionally been associated with the regulation of fluid and electrolyte balance. in this review we summarize the data which ascribes a completely new function to this system, i.e., the regulation of alcohol consumption. in addition, we suggest a possible mechanism for this effect based on the concept of a satiety or stop process. the approach taken was to examine the effect on alcohol intake of a wide variety of drug, genetic, dietary, surgical and neurosurgic ... | 2007 | 1852316 |
| use of ether in life-threatening acute severe asthma. | two patients with acute severe asthma who had failed to improve with conventional treatment, mechanical ventilation, and halothane showed prompt bronchodilator response following administration of diethyl ether by inhalation. airway pressures fell, and there was a dramatic improvement in blood gas analysis and clinical condition. | 2007 | 2857266 |
| [diagnosis of acute myositis. magnetic resonance tomography with gd-dtpa]. | 2007 | 1932732 | |
| body-image therapy. | body image is a complex interplay of factors resulting in a sense of the body perceived by that individual. in eating-disorder clients, there is a distortion between their perceived image of their body and its actuality. this is combined with a sense of dissatisfaction and alienation of mind and body. cognitive, right-brain, and kinesthetic strategies are described that seek to decrease distortion and dissatisfaction and facilitates individuation-separation and a reintegration of the self. these ... | 2007 | 1891405 |
| [a tonsillolith]. | the author describes a tonsillolith accidentally detected in a peritonsillar abscess in a 10-year-old girl. the concrement 26 x 4 mm in size, weighing 0.84 g was analyzed by infrared spectroscopy, x-ray diffraction which revealed that it was a dahllite. the surface of the concrement was documented by a scanning microscope. the authors give an account of 29 published cases of tonsilloliths and in the discussion they analyze the causes of development of these concrements in tonsils. | 2007 | 2292111 |