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the signature of liver cancer in immune cells dna methylation.the idea that changes to the host immune system are critical for cancer progression was proposed a century ago and recently regained experimental support.201829375724
moving in the anthropocene: global reductions in terrestrial mammalian movements.animal movement is fundamental for ecosystem functioning and species survival, yet the effects of the anthropogenic footprint on animal movements have not been estimated across species. using a unique gps-tracking database of 803 individuals across 57 species, we found that movements of mammals in areas with a comparatively high human footprint were on average one-half to one-third the extent of their movements in areas with a low human footprint. we attribute this reduction to behavioral change ...201829371471
complete genome sequence of mycobacterium sp. strain 3519a.mycobacterium sp. strain 3519a is a nontuberculous mycobacterium isolated from sputum from a cambodian patient with a pulmonary infection. we report here the first complete 7.3-mbp-long genome sequence of mycobacterium sp. 3519a with 66.35% gc content, encoding 7,029 protein-coding genes, 50 trnas, and 5 rrna genes.201829371369
draft genome sequence of tetzosporium hominis vt-49 gen. nov., sp. nov., isolated from the dental decay plaque of a patient with periodontitis.here, we report the draft genome sequence of tetzosporium hominis vt-49 gen. nov., sp. nov., isolated from the dental plaque of a patient with severe periodontal disease. the draft genome sequence was 2,780,751 bp in length with a 43.3% g+c content. we detected 3,001 genes, which are predicted to encode proteins that regulate both virulence and antibiotic resistance.201829371362
draft genome sequence of the antimycin-producing bacterium streptomyces sp. strain sm8, isolated from the marine sponge haliclona simulans.streptomyces sp. strain sm8, isolated from haliclona simulans, possesses antifungal and antibacterial activities and inhibits the calcineurin pathway in yeast. the draft genome sequence is 7,145,211 bp, containing 5,929 predicted coding sequences. several secondary metabolite biosynthetic gene clusters are present, encoding known and novel metabolites, including antimycin.201829371360
genome sequence of verrucomicrobium sp. strain gas474, a novel bacterium isolated from soil.verrucomicrobium sp. strain gas474 was isolated from the mineral soil of a temperate deciduous forest in central massachusetts. here, we present the complete genome sequence of this phylogenetically novel organism, which consists of a total of 3,763,444 bp on a single scaffold, with a 65.8% gc content and 3,273 predicted open reading frames.201829371348
motives for sickness presence among students at secondary school: a cross-sectional study in five european countries.this article investigates various motives for sickness presence (sp) among students in secondary school.201829371281
confirming rickettsia rickettsii as the etiological agent of lethal spotted fever group rickettsiosis in human patients from espírito santo state, brazil.although espírito santo state is considered an endemic area for brazilian spotted fever (bsf) with related lethal cases, it also constitutes the only state of southeastern brazil that currently lacks a specific confirmation of the specific rickettsial agent. in an attempt to a species level confirmation of the etiological agent of fatal rickettsiosis cases in espírito santo state, in this study we tested human sera obtained between 2015 to 2017 by means of qpcr and subsequent conventional pcr pr ...201829371125
atlantic forest to the all americas: biogeographical history and divergence times of neotropical ficus (moraceae).ficus (moraceae) is well diversified in the neotropics with two lineages inhabiting the wet forests of this region. the hemiepiphytes of section americanae are the most diversified with c. 120 species, whereas section pharmacosycea includes about 20 species mostly with a terrestrial habit. to reconstruct the biogeographical history and diversification of ficus in the americas, we produced a dated bayesian phylogenetic hypothesis of neotropical ficus including two thirds of the species sequenced ...201829371027
'massilimalia timonensis' sp. nov., a new bacterium species isolated from human faeces after decontamination with alcohol.we describe the main characteristics of a new bacterial species 'massilimalia timonensis' sp. nov. the type strain marseille-p3753t (=csur p3753) was isolated from the stool of a healthy senegalese man.201829379603
identification of a biosynthetic gene cluster for the polyene macrolactam sceliphrolactam in a streptomyces strain isolated from mangrove sediment.streptomyces are a genus of actinobacteria capable of producing structurally diverse natural products. here we report the isolation and characterization of a biosynthetically talented streptomyces (streptomyces sp. sd85) from tropical mangrove sediments. whole-genome sequencing revealed that streptomyces sp. sd85 harbors at least 52 biosynthetic gene clusters (bgcs), which constitute 21.2% of the 8.6-mb genome. when cultivated under lab conditions, streptomyces sp. sd85 produces sceliphrolactam, ...201829371699
induction of calcite precipitation through heightened production of extracellular carbonic anhydrase by co2 sequestering bacteria.the thermo-alkalotolerant bacterium exhibiting heightened extracellular carbonic anhydrase (ca) activity, survived at 100 mm sodium bicarbonateand 5% gaseous co2 was identified as bacillus sp. by 16s rrna sequencing. extracellular carbonic anhydrase was purified by ammonium sulfate precipitation, gel filtration chromatography and affinity chromatography with a yield of 46.61% and specific activity of 481.66 u/mg. the size of purified carbonic anhydrase was approximately 28 kda in sds-page gel fi ...201829370973
genome-wide characterization of genetic variants and putative regions under selection in meat and egg-type chicken lines.meat and egg-type chickens have been selected for several generations for different traits. artificial and natural selection for different phenotypes can change frequency of genetic variants, leaving particular genomic footprints throghtout the genome. thus, the aims of this study were to sequence 28 chickens from two brazilian lines (meat and white egg-type) and use this information to characterize genome-wide genetic variations, identify putative regions under selection using fst method, and f ...201829370772
systematic review of published data on the worldwide prevalence of john cunningham virus (jcv) in patients with multiple sclerosis.the john cunningham virus (jcv) is a polyoma virus that infects humans mainly in childhood or adolescence, and presents no symptomatic manifestations. jcv can cause progressive multifocal leukoencephalopathy (pml) in immunosuppressed individuals, including those undergoing treatment for multiple sclerosis (ms) and neuromyelitis optica (nmo). pml is a severe and potentially fatal disease of the brain. the prevalence of jcv antibodies has been described to be between 50% and 90% in human serum. th ...201829370683
comparison of surgical and conservative treatment of rockwood type-iii acromioclavicular dislocation: a meta-analysis.there is no consensus on the effects of surgical versus conservative treatment on rockwood type-iii dislocation of the acromioclavicular joint in general orthopedic practice. the objective of this meta-analysis was to compare the clinical outcomes of patients managed surgically and conservatively following type-iii acromioclavicular (ac) dislocation.201829369191
functional performance comparison between real and virtual tasks in older adults: a cross-sectional study.ageing is usually accompanied by deterioration of physical abilities, such as muscular strength, sensory sensitivity, and functional capacity, making chronic diseases, and the well-being of older adults new challenges to global public health.201829369177
tp53 is required for becn1- and atg5-dependent cell death induced by sphingosine kinase 1 inhibition.the bioactive sphingolipid metabolite sphingosine-1-phosphate (s1p) and the enzyme that produces it, sphk1 (sphingosine kinase 1), regulate many processes important for the etiology of cancer. it has been suggested that sphk1 levels are regulated by the tumor suppressor protein tp53, a key regulator of cell cycle arrest, apoptosis, and macroautophagy/autophagy. however, little is still known of the relationship between tp53 and sphk1 activity in the regulation of these processes. to explore this ...201829368980
transperitoneal laparoscopic pyeloplasty in children: does upper urinary tract anomalies affect surgical outcomes?to assess the feasibility and outcomes of laparoscopic pyeloplasty in children with complex ureteropelvic junction obstruction (upjo) and compare to children with iso-lated upjo without associated urinary tract abnormalities.201829368877
applying the robins-i tool to natural experiments: an example from public health.a new tool to assess risk of bias in non-randomised studies of interventions (robins-i) was published in autumn 2016. robins-i uses the cochrane-approved risk of bias (rob) approach and focusses on internal validity. as such, robins-i represents an important development for those conducting systematic reviews which include non-randomised studies (nrs), including public health researchers. we aimed to establish the applicability of robins-i using a group of nrs which have evaluated non-clinical p ...201829368630
frequency-dependent airway hyperresponsiveness in a mouse model of emphysema and allergic inflammation.asthma and chronic obstructive pulmonary disease (copd), chronic airway inflammatory diseases characterized by airflow limitation, have different etiologies and pathophysiologies. asthma-copd overlap (aco) has recently been used for patients with mixed asthma and copd. the pathophysiological mechanisms of aco have not been clearly understood due to the lack of an appropriate murine model. to investigate its pathophysiology, we examined a murine model by allergen challenge in surfactant protein-d ...201829368450
geographical and experimental contexts modulate the effect of warming on top-down control: a meta-analysis.ecologists have extensively investigated the effect of warming on consumer-resource interactions, with experiments revealing that warming can strengthen, weaken or have no net effect on top-down control of resources. these experiments have inspired a body of theoretical work to explain the variation in the effect of warming on top-down control. however, there has been no quantitative attempt to reconcile theory with outcomes from empirical studies. to address the gap between theory and experimen ...201829368449
seed-dispersal interactions in fragmented landscapes - a metanetwork approach.mutualistic interactions repeatedly preserved across fragmented landscapes can scale-up to form a spatial metanetwork describing the distribution of interactions across patches. we explored the structure of a bird seed-dispersal (bsd) metanetwork in 16 neotropical forest fragments to test whether a distinct subset of bsd-interactions may mediate landscape functional connectivity. the metanetwork is interaction-rich, modular and poorly connected, showing high beta-diversity and turnover of specie ...201829368364
superior anticancer activity is demonstrated by total extract of curcuma longa l. as opposed to individual curcuminoids separated by centrifugal partition chromatography.three curcuminoids: bisdemethoxycurcumin, demethoxycurcumin, and curcumin from turmeric were successfully separated by a high capacity solvent system composed of heptane: chloroform: methanol: water mixture (5: 6: 3: 2 v/v/v/v) tailored for centrifugal partition chromatographs at k-values of 0.504, 1.057, 1.644, respectively. these three ferulic acid derivatives obtained at a purity rate exceeding 95% were analysed by an hplc-ms spectrometer. turmeric extract inhibited the proliferation/viabilit ...201829368356
a mild case of molybdenum cofactor deficiency defines an alternative route of mocs1 protein maturation.molybdenum cofactor deficiency is an autosomal recessive inborn error of metabolism, which results from mutations in genes involved in moco biosynthesis. moco serves as a cofactor of several enzymes, including sulfite oxidase. mocd is clinically characterized by intractable seizures and severe, rapidly progressing neurodegeneration leading to death in early childhood in the majority of known cases. here we report a patient with an unusual late disease onset and mild phenotype, characterized by a ...201829368224
author correction: characterization of truncated dsz operon responsible for dibenzothiophene biodesulfurization in rhodococcus sp. fum94.the original version of this article unfortunately contained a mistake in the caption of figs. 5 and 6.201829368154
irritant-induced asthma to hypochlorite in mice due to impairment of the airway barrier.inhalation of commonly present irritants, such as chlorine and chlorine derivatives, can cause adverse respiratory effects, including irritant-induced asthma (iia). we hypothesize that due to airway barrier impairment, exposure to hypochlorite (clo-) can result in airway hypersensitivity. c57bl/6 mice received an intra-peritoneal (i.p.) injection of the airway damaging agent naphthalene (na, 200 mg/kg body weight) or vehicle (mineral oil, mo). in vivo micro-computed tomography (ct) images of the ...201829368146
two new gonad-infecting species of philometra costa, 1845 (nematoda: philometridae) from trachinus spp. (osteichthyes: trachinidae) in the gulf of hammamet, tunisia.based on light and scanning electron microscopical studies, two new gonad-infecting species of philometra costa, 1845, p. draco n. sp. and p. radiata n. sp. (nematoda: philometridae), are described from the marine perciform fishes trachinus draco (linnaeus) and t. radiatus (linnaeus) (both trachinidae), respectively, in the gulf of hammamet, off the northeastern coast of tunisia. philometra draco n. sp. and p. radiata n. sp. can be separated from other gonad-infecting species of this genus by th ...201829368129
enhancement of docosahexaenoic acid (dha) production from schizochytrium sp. s31 using different growth medium conditions.schizochytrium species is one of the most studied microalgae for production of docosahexaenoic acid (dha) which is an omega-3 fatty acid with positive effects for human health. however, high cost and low yield in production phase makes optimization of cultivation process inevitable. we focus on the optimization of dha production using schizochytrium sp. using different media supplements; glucose, fructose and glycerol as carbon variants, proteose peptone and tryptone as nitrogen variants. the hi ...201829368055
fungal diversity of human gut microbiota among eutrophic, overweight, and obese individuals based on aerobic culture-dependent approach.fungi have a complex role in the intestinal tract, influencing health and disease, with dysbiosis contributing to obesity. our objectives were to investigate fungal diversity in human gut microbiota among eutrophic, overweight, and obese. epidemiological and nutritional information were collected from adult individuals, as well as stool samples processed for selective fungi isolation and identification by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (yeasts) or mi ...201829368026
contiguous multiple π-coordination of π-conjugated polyenes: bonding nature and charge delocalization behaviour of polyene-(palladium chain) sandwich clusters.the contiguous multiple π-coordination (cmπc) bonds are formed at the molecular interface between the extended π-conjugated sp2-carbon framework and metal-metal moieties. however, the static properties including the bonding nature of the cmπc bonds have not been well-understood. here we report the charge delocalization behavior and bonding nature of the polyene-(palladium chain) sandwich clusters. we observed the chain-length dependent 13c nmr chemical shifts of the terminal phenyl groups in [pd ...201829367984
erratum: variable frequency of lrrk2 variants in the latin american research consortium on the genetics of parkinson's disease (large-pd), a case of ancestry.[this corrects the article doi: 10.1038/s41531-017-0020-6.].201829367946
articular reconstruction of the humeral head with autogenous allograft in the treatment of the osteonecrosis.the authors describe a surgical biological reconstruction of the humeral head with frozen autogenous allograft technique for the treatment of young patients with focal osteonecrosis of the humeral head. this represents a possible alternative, maybe even definitive for some patients, when compared to hemiarthroplasty or total shoulder arthroplasty. the technique consists of the fixation of a frozen autogenous allograft with previously-molded articular cartilage from the humeral head, after cleans ...201829367916
epidemiology of cauda equina syndrome. what changed until 2015.the primary objective of this study was to analyze the characteristics and outcomes of cases admitted to hospital with cauda equina syndrome (ces) at the institute of orthopedics and traumatology (iot) from 2005 to 2015. secondly, this article is a continuation of the epidemiological work of the same base published in 2013, and will be important for other comparative studies to a greater understanding of the disease and its epidemiology.201829367915
mind the gap between the fracture line and the length of the working area: a 2-d finite element analysis using an extramedullary fixation model.to determine the ideal working area for a simple transverse fracture line treated with a bridge plate.201829367912
bicipital aponeurosis. anatomical study and clinical implications.the aim of this study was to analyze the anatomic variations of the bicipital aponeurosis (ba) (lacertus fibrosus) and its implications for the compression of the median nerve, which is positioned medially to the brachial artery, passing under the bicipital aponeurosis.201829367910
surgical treatment of pectoralis major muscle rupture with adjustable cortical button.to assess the tendon reconstruction technique for total rupture of the pectoralis major muscle using an adjustable cortical button.201829367908
the effects of ethyl-2-cyanoacrylate and butyl-2-cyanoacrylate in the process of bone healing in rats. a controlled experimental study.synthetic adhesives are used by various medical specialties, especially in surgery; however, studies reporting their use in orthopedic practice are scarce. the aim of this study was to compare the results in using ethyl-2-cyanoacrylate or butyl-2-cyanoacrylate in the treatment of fractures in rats.201829367907
epidemiological characteristics of patients with pelvic tumors submitted to surgical treatment.describe the epidemiological profile of patients with primary or secondary neoplastic lesions in the pelvis who required a surgical procedure such as hemipelvectomy.201829367904
venous thromboembolism prophylaxis after total knee arthroplasty (tka): aspirin vs. rivaroxaban.to compare the efficacy and safety of aspirin and rivaroxaban in preventing venous thromboembolism (vte) after total knee arthroplasty (tka).201829367902
evaluation of interobserver agreement in albertoni's classification for mallet finger.to measure the reliability of albertoni's classification for mallet finger.201829367899
plant-pathogen interactions: leaf physiology alterations in poplars infected with rust (melampsora medusae).rust produced by melampsora sp. is considered one of the most relevant diseases in poplar plantations. growth reduction in poplar plantations takes place because rust, like other pathogens, alters leaf physiology. there is not a complete evaluation of several of the physiological traits that can be affected by rust at leaf level. therefore, the aim of this work was to evaluate, in an integrative way and in the same pathosystem, which physiological processes are affected when populus deltoides ba ...201829370416
alterations of hiv-1 envelope phenotype and antibody-mediated neutralization by signal peptide mutations.hiv-1 envelope glycoprotein (env) mediates virus attachment and entry into the host cells. like other membrane-bound and secreted proteins, hiv-1 env contains at its n terminus a signal peptide (sp) that directs the nascent env to the endoplasmic reticulum (er) where env synthesis and post-translational modifications take place. sp is cleaved during env biosynthesis but potentially influences the phenotypic traits of the env protein. the env sp sequences of hiv-1 isolates display high sequence v ...201829370305
identification of qtl conferring resistance to stripe rust (puccinia striiformis f. sp. hordei) and leaf rust (puccinia hordei) in barley using nested association mapping (nam).the biotrophic rust fungi puccinia hordei and puccinia striiformis are important barley pathogens with the potential to cause high yield losses through an epidemic spread. the identification of qtl conferring resistance to these pathogens is the basis for targeted breeding approaches aiming to improve stripe rust and leaf rust resistance of modern cultivars. exploiting the allelic richness of wild barley accessions proved to be a valuable tool to broaden the genetic base of resistance of barley ...201829370232
effects of glutamine and alanine supplementation on central fatigue markers in rats submitted to resistance training.recent evidence suggests that increased brain serotonin synthesis impairs performance in high-intensity intermittent exercise and specific amino acids may modulate this condition, delaying fatigue. this study investigated the effects of glutamine and alanine supplementation on central fatigue markers in rats submitted to resistance training (rt). wistar rats were distributed in: sedentary (sed), trained (con), trained and supplemented with alanine (ala), glutamine and alanine in their free form ...201829370091
study of electronic structure, thermal conductivity, elastic and optical properties of α, β, γ-graphyne.in recent years, graphyne was found to be the only 2d carbon material that has both sp and sp² hybridization. it has received significant attention because of its great potential in the field of optoelectronics, which arises due to its small band gap. in this study, the structural stability, electronic structure, elasticity, thermal conductivity and optical properties of α, β, γ-graphynes were investigated using density functional theory (dft) systematically. γ-graphyne has the largest negative ...201829370070
how has the affordable care act changed outcomes in emergency general surgery?lack of insurance coverage increases complications and mortality from surgical procedures. the 2014 affordable care act (aca) open enrollment (oe) insured more americans, but it is unknown if this improved outcomes from emergency general surgery (egs) procedures. this study seeks to determine how aca oe coverage changes outcomes in egs.201829370065
polyoxometalate-assisted, one-pot synthesis of a pentakis[(triphenylphosphane)gold]ammonium(2+) cation containing regular trigonal-bipyramidal geometries of five bonds to nitrogen.novel intercluster compounds consisting of pentakis[(triphenylphosphane)gold]ammonium(2+) cation (1) and keggin polyoxometalate (pom) anions, i.e., {[au(pph3)]5(μ5-n)}3[α-pm12o40]2 (1-pw for m = w; 1-pmo for m = mo), were synthesized in 30-36% yield by one-pot reaction of the protonic acid form of the keggin poms, h3[α-pm12o40]·nh2o (n = 13 for m = w; n = 15 for m = mo) with monomeric (triphenylphosphane)gold(i) carboxylate [au(rs-pyrrld)(pph3)] [rs-hpyrrld = (rs)-2-pyrrolidone-5-carboxylic acid ...201829369627
elimination of stem-like cancer cell side-population by auranofin through modulation of ros and glycolysis.cancer side-population (sp) represents a sub-population of stem-like cancer cells that have an important role in drug resistance due to their high expression of the atp-binding cassette transporter abcg2 involved in drug export. auranofin (af), a clinical drug of gold complex that is used in treatment of rheumatoid arthritis, has been reported inducing tumor antiproliferation. however, whether af can impact sp cells remains unclear. our study showed that af caused a depletion of sp cells and a d ...201829367724
high diversity and abundance of cultivable tetracycline-resistant bacteria in soil following pig manure application.by performing a microcosm experiment mimicking fertilization, we assessed the dynamic distribution of tetracycline-resistant bacteria (trb) and corresponding tetracycline resistance genes (trgs) from pig manure (pm) to the fertilized soil, by culture-dependent methods and pcr detection. cultivable trb were most abundant in pm, followed by fertilized soil and unfertilized soil. by restriction fragment length polymorphism (rflp) analysis, trb were assigned to 29, 20, and 153 operational taxonomic ...201829367695
ultrasensitive reversible chromophore reaction of bodipy functions as high ratio double turn on probe.chromophore reactions with changes to conjugation degree, especially those between the conjugated and unconjugated state, will bring a large spectral variation. to realize such a process, a meso-naked bodipy (mnbod) with two electron-withdrawing groups around the core is designed and synthesized. the resulting system is extremely sensitive to bases. the red, highly fluorescent solution readily becomes colorless and non-fluorescent after base addition; however, the color and fluorescence can be t ...201829367661
mumiamicin: structure and bioactivity of a new furan fatty acid from mumia sp. ysp-2-79.a new antibiotic, designated mumiamicin, was isolated from the cultured broth of the rare actinomycete strain, mumia sp. ysp-2-79, by diaion hp-20, silica gel and ods column chromatography, followed by hplc purification. the chemical structure of mumiamicin was elucidated as a new furan fatty acid by nuclear magnetic resonance and mass spectrometry. mumiamicin showed antimicrobial activity and antioxidative activity.201829367492
optimization of enzymatic cell disruption for improving lipid extraction from schizochytrium sp. through response surface methodology.this study is aimed to explore the optimal conditions of cell disruption in the extraction algae oil process, using alkaline protease to disrupt cell of schizochytrium sp. to extract oil in this paper. the effects of enzymatic lysis temperature, enzymatic lysis time, enzyme dosage and ph value on oil yield and dha yield were studied. through the combination of single factor test and response surface design, the optimal cell disruption conditions were screened out. the fatty acid composition of a ...201829367487
the complexity of high-frequency electric fields degrades electrosensory inputs: implications for the jamming avoidance response in weakly electric fish.sensory systems encode environmental information that is necessary for adaptive behavioural choices, and thus greatly influence the evolution of animal behaviour and the underlying neural circuits. here, we evaluate how the quality of sensory information impacts the jamming avoidance response (jar) in weakly electric fish. to sense their environment, these fish generate an oscillating electric field: the electric organ discharge (eod). nearby fish with similar eod frequencies perform the jar to ...201829367237
dental age assessment: which is the most applicable method?to evaluate which method is the most applicable for estimating estimate dental age in brazilian children, nolla or demirjian. for this purpose, both methods were reviewed and the differences between them brought to light. a total of 403 healthy children between the ages of 7 and 13 years with satisfactory panoramic radiographs, similar socio-economic background and ethnic origin were included. panoramic radiographs were examined by the nolla and demirjian methods. dental age was calculated for b ...201829367174
effects of supplementation with vegetable oils, including castor oil, on milk production of ewes and on growth of their lambs.the objectives in this experiment were to compare the effects of castor oil, canola oil or sunflower oil on lactation performance, milk composition and milk fatty acid (fa) profile in santa inês ewes and on growth of lambs. forty-four ewes (66.9 ± 4.7 kg of initial bw, mean ± sd) were penned individually with their lambs and used in a randomized complete block design with 11 blocks and four diets. the experimental diets were as follow: 1) basal diet without added oil (control), 2) 30 g fa/kg dm ...201829365200
estimation of broiler responses to increased dietary methionine hydroxy analogue [dl-2-hydroxy-(4-methylthio) butanoic acid] using linear and nonlinear regression models.as the first limiting amino acid in corn-soy broiler diets, methionine (met) is supplemented using commercial synthetic sources as demanded to obtain economic feed formulations. the met analogue dl-2-hydroxy-4-(methylthio)-butanoic acid (hmtba) is largely utilized with that objective. this study intended to obtain responses of broilers fed with increasing levels of hmtba, from 28 to 42 d, such that economic returns can be calculated. a total of 2,106 cobb × cobb 500 one-day-old male broilers was ...201829365195
pneumothorax: between the beach and the stratosphere. 201829365008
recommendations for the pharmacological treatment of copd: questions and answers.the treatment of copd has become increasingly effective. measures that range from behavioral changes, reduction in exposure to risk factors, education about the disease and its course, rehabilitation, oxygen therapy, management of comorbidities, and surgical and pharmacological treatments to end-of-life care allow health professionals to provide a personalized and effective therapy. the pharmacological treatment of copd is one of the cornerstones of copd management, and there have been many adva ...201829365005
sleep quality in medical students: a comparison across the various phases of the medical course.to evaluate and compare subjective sleep quality in medical students across the various phases of the medical course.201829365004
pneumonia mortality trends in all brazilian geographical regions between 1996 and 2012.to analyze the temporal trends in pneumonia mortality rates (standardized by age, using the 2010 population of brazil as the standard) in all brazilian geographical regions between 1996 and 2012.201829365002
prognostic studies for health care decision making. 201829364997
jbp and bibliometric índices. 201829364994
a wolf in sheep's clothing: the description of a fly resembling jumping spider of the genus scoturius simon, 1901 (araneae: salticidae: huriini).fly resemblance in arthropods is much less common than e.g., resemblance to ants or wasps, and has been mainly observed in beetles. putative fly mimicry in arachnids has been reported only from the jumping spider genus saitis. however, recent literature has attributed the fly-resembling characteristics in saitis to sexual signalling during courtship. the lack of observation of fly mimicry in spiders is not surprising as flies belong to the most important prey item group of spiders. in this study ...201829364905
de novo characterization of transcriptomes from two north american papaipema stem-borers (lepidoptera: noctuidae).stem-borers in the genus papaipema (lepidoptera: noctuidae) range from highly polyphagous agricultural pests to specialists on more than 20 families of flowering plants, many of them highly toxic. papaipema is the largest genus of noctuids endemic to north america and provides an excellent study system for the evolution of noctuid host plant use. to improve the availability of genomic resources for such investigations, we performed de novo transcriptome sequencing and assembly for two specialist ...201829364900
comparative digital gene expression analysis of tissue-cultured plantlets of highly resistant and susceptible banana cultivarsin response to fusarium oxysporum.banana fusarium wilt caused by fusarium oxysporum f. sp. cubense (foc) is one of the most destructive soil-borne diseases. in this study, young tissue-cultured plantlets of banana (musa spp. aaa) cultivars differing in foc susceptibility were used to reveal their differential responses to this pathogen using digital gene expression (dge). data were evaluated by various bioinformatic tools (venn diagrams, gene ontology (go) annotation and kyoto encyclopedia of genes and genomes (kegg) pathway ana ...201829364855
pseudoxanthoma elasticum-like papillary dermal elastolysis. 201829364463
pseudo "fringe sign" in frontal fibrosing alopecia. 201829364461
primary treatment of early fistula of parotid duct with botulinum toxin type a injection.salivary duct injury can be idiopathic, iatrogenic, or post-trauma and may result in sialocele or fistula. most injuries regress spontaneously and botulinum toxin a is one of several therapeutic possibilities. we report a case of iatrogenic injury to the parotid duct after mohs' micographic surgery for a squamous cell carcinoma excision in the left jaw region, treated by injection of botulinum toxin type a. although the fistula by duct injury can be self-limiting, botulinum toxin injection by pr ...201829364451
sweet syndrome-like cutaneous drug reaction.cutaneous drug reactions are adverse reactions to medications that may present with different clinical features, ranging from localized to generalized lesions. in this report we describe a case of an unusual drug reaction, resembling the morphology of sweet syndrome lesions. the patient had a psychiatric illness and was using thioridazine hydrochloride for one year. he developed infiltrated and grouped erythematous lesions on the elbows and knees three days after commencing multiple drugs (prome ...201829364449
milker's nodules: classic histological findings.milker's nodule is an occupational dermatovirose caused by parapoxvirus, which is self-limited and, due to the lack of information of health professionals, may lead to underdiagnosis. we present two cases with exuberant manifestations and classic histopathologic findings. case 1: male, 19 years of age, milker, presented nodules and blisters on his palm for 15 days. case 2: male, 33 years of age, administrative assistant, presented erythematous nodules on his palms with lymphangitis for 5 days. h ...201829364443
rare desmoplastic trichilemmoma associated with sebaceous nevus.nevus sebaceous of jadassohn is a congenital hamartoma that usually affects the scalp and face. several benign or malignant neoplasias may develop in the lesion and the most common are trichoblastoma, syringocystadenoma papilliferum, and basal cell carcinoma. trichilemmoma is a benign solid tumor originating from external sheath cells of pilosebaceous follicles. when it is characterized by a central zone of desmoplasia, it is called desmoplastic trichilemmoma. we report a case of a 58-year-old p ...201829364442
cancer immunology and melanoma immunotherapy.the stimulation of the immune system, in order to generate an attack against cancer cells, similarly to that which occurs in infectious disease, has long been matter of interest in oncology; however, only limited success has been achieved, with different treatment strategies tested in recent years. the development of new immune checkpoint inhibitors is currently changing this scenario, and immunotherapy is becoming a real choice among traditional cytotoxic treatments to fight cancer. recent repo ...201829364441
prevalence and heritability of psoriasis and benign migratory glossitis in one brazilian population.an oral condition associated to psoriasis is benign migratory glossitis. the review of the literature does not show any publication about heritability in both soriasis and benign migratory glossitis and prevalence of psoriasis in the brazilian population.201829364438
rapidly progressive subacute motor neuronopathy disclosing type b2 thymoma. 201829364399
proximal limb weakness and amyotrophy in a man with silicosis. 201829364397
autoimmune encephalitis: a review of diagnosis and treatment.autoimmune encephalitis (aie) is one of the most common causes of noninfectious encephalitis. it can be triggered by tumors, infections, or it may be cryptogenic. the neurological manifestations can be either acute or subacute and usually develop within six weeks. there are a variety of clinical manifestations including behavioral and psychiatric symptoms, autonomic disturbances, movement disorders, and seizures. we reviewed common forms of aie and discuss their diagnostic approach and treatment ...201829364393
a brazilian-portuguese version of the kinesthetic and visual motor imagery questionnaire.motor imagery has emerged as a potential rehabilitation tool in stroke. the goals of this study were: 1) to develop a translated and culturally-adapted brazilian-portugese version of the kinesthetic and visual motor imagery questionnaire (kviq20-p); 2) to evaluate the psychometric characteristics of the scale in a group of patients with stroke and in an age-matched control group; 3) to compare the kviq20 performance between the two groups. test-retest, inter-rater reliabilities, and internal con ...201829364391
medical perception of stroke care conditions in brazil.stroke is currently the second leading cause of death in brazil. neurologists' reports on the absence of adequate resources for stroke care are frequent; however, there are no objective data on this perception.to assess the perception of neurologists of stroke care conditions in brazil. neurologists from all over brazil were surveyed by means of an anonymous questionnaire about the main shortcomings in stroke care, focusing particularly on physical structure and infrastructure (diagnostic method ...201829364389
multiple sclerosis risk perception and acceptance for brazilian patients.the perception of multiple sclerosis (ms) severity and risk associated with therapies might influence shared decision making in different countries. we investigated the perception of ms severity and factors associated with risk acceptance in brazil in 96 patients with relapsing-remitting ms using a standardized questionnaire and compared this with two european cohorts. multiple sclerosis was perceived as a very severe disease and the risk of developing progressive multifocal leukoencephalopathy ...201829364388
compensatory class iii malocclusion treatment associated with mandibular canine extractions.skeletal class iii malocclusions are ideally treated with orthodontic-surgical approaches. however, if there are no significant soft tissue implications and the patient does not want to undergo orthognatic surgery, other treatment options may be considered. the current case report describes a compensatory alternative for class iii malocclusion treatment, by means of mandibular canine extractions. this treatment alternative provided facial profile and occlusal improvement, which remains stable se ...201829364384
stability of beta-titanium t-loop springs preactivated by gradual curvature.evaluate changes in the force system of t-loop springs (tls) preactivated by curvature, due to stress relaxation.201829364381
"maxillary lateral incisor partial anodontia sequence": a clinical entity with epigenetic origin.the relationship between maxillary lateral incisor anodontia and the palatal displacement of unerupted maxillary canines cannot be considered as a multiple tooth abnormality with defined genetic etiology in order to be regarded as a "syndrome". neither were the involved genes identified and located in the human genome, nor was it presumed on which chromosome the responsible gene would be located. the palatal maxillary canine displacement in cases of partial anodontia of the maxillary lateral inc ...201829364376
public health policies and scientific evidence. 201829364373
a new way to communicate science in the era of big data and citizen science. 201829364372
comment to: ii brazilian consensus on the use of human immunoglobulin in patients with primary immunodeficiencies. einstein (são paulo). 2017;15(1):1-16. 201829364371
munchausen syndrome and munchausen syndrome by proxy: a narrative review.the munchausen syndrome and munchausen syndrome by proxy are factitious disorders characterized by fabrication or induction of signs or symptoms of a disease, as well as alteration of laboratory tests. people with this syndrome pretend that they are sick and tend to seek treatment, without secondary gains, at different care facilities. both syndromes are well-recognized conditions described in the literature since 1951. they are frequently observed by health teams in clinics, hospital wards and ...201829364370
regulation of adiposity by mtorc1.obesity is characterized by an excessive increase in the adipose tissue mass, and is associated with higher incidence of several chronic metabolic diseases, such as type 2 diabetes. therefore, its increasing prevalence is a public health concern, and it is important to better understand its etiology to develop new therapeutic strategies. evidence accumulated over the years indicates that obesity is associated with a marked activation in adipose tissue of the mechanistic target of rapamycin compl ...201829364369
initial experience with single-port robotic hysterectomy.this article presents the first series of robotic single-port hysterectomy cases performed at a hospital in brazil.201829364368
new therapeutic option in genitourinary syndrome of menopause: pilot study using microablative fractional radiofrequency.to evaluate the clinical response of patients with symptoms of genitourinary syndrome of menopause after application of microablative fractional radiofrequency in the vagina and vaginal introitus.201829364367
urinary beta-trace protein gene expression analysis in type 2 diabetes mellitus patients.to evaluate the gene expression of beta-trace protein in urine of diabetic patients, with no reduction in glomerular filtration rate, which was defined as below 60ml/min/1.73m2.201829364366
emergency severity index: accuracy in risk classification.to verify agreement between estimative of predicted resources using the adapted emergency severity index and the real amount of resources used by patients. to analyze the variables number of years since graduation, years of work experience and years of experience in emergency services especially with accurate anticipation of resources need.201829364364
do not attempt resuscitation orders at the emergency department of a teaching hospital.to identify factors associated with not attempting resuscitation.201829364362
vascular endothelial growth factor gene variations as a risk predictor in disc degeneration.to evaluate the frequency of polymorphisms in the vascular endothelial growth factor (vegf) gene, as well as to identify a potential risk haplotype among the polymorphic regions in this gene in patients with disc degeneration and in the control group.201829364361
novel multidisciplinary approach to monitor and treat fetuses with gastroschisis using the svetliza reducibility index and the exit-like procedure.to describe our initial experience with a novel approach to follow-up and treat gastroschisis in "zero minute" using the exitlike procedure.201829364360
monitoring and treating fetuses with gastroschisis using the svetliza reducibility index (sri) and the exit-like procedure - a novel approach. 201829364359
effectiveness of a web-based intervention in reducing binge drinking among nightclub patrons.objective to evaluate the effectiveness of a web-based intervention in reducing binge drinking among nightclub patrons after six months. methods we carried out a website survey with probabilistic sample in 31 nightclubs in the city of são paulo, brazil, which originated a randomized controlled trial with 1,057 participants. those classified as problem drinkers (n = 465) using the alcohol use disorders identification test were randomized into two study groups - intervention and control. the web-b ...201829364357
influence of skin cold sensation threshold in the occurrence of dental sensitivity during dental bleaching: a placebo controlled clinical trial.this study verified the occurrence of dental sensitivity in patients submitted to a 35% hydrogen peroxide based product (whiteness hp maxx 35% - fgm), skin cold sensation threshold (scst) and its influence on dental sensitivity. sixty volunteers were divided into 4 groups (n = 15), according to scst (low: gi and giii, and high: gii and iv) and bleaching treatment (hydrogen peroxide: gi and gii, and placebo: giii and giv). scst was determined in the inner forearm for 6 different times using a neu ...201829364338
construction of c(sp2)-x (x = br, cl) bonds through a copper-catalyzed atom-transfer radical process: application for the 1,4-difunctionalization of isoquinolinium salts.a highly efficient cu-catalyzed 1,4-difunctionalization of isoquinolinium salts was developed with ether and x- (x = br, cl) as the halogen source under mild conditions. this transformation involves the combination of oxidative coupling and copper-catalyzed halogen atom-transfer radical processes. this method not only provides an efficient way to prepare various substituted azaarenes but also achieves the selective construction of c(sp2)-x (x = br, cl) bonds from a halogen anion and nucleophilic ...201829363974
heterologous production and purification of a functional chloroform reductive dehalogenase.reductive dehalogenases (rdases) are key enzymes involved in the respiratory process of anaerobic organohalide respiring bacteria (orb). heterologous expression of respiratory rdases is desirable for structural and functional studies; however, there are few reports of successful expression of these enzymes. dehalobacter sp. strain unswdhb is an orb, whose preferred electron acceptor is chloroform. this study describes efforts to express recombinant reductive dehalogenase (tmra), derived from uns ...201829363941
biopolymer-based membranes associated with osteogenic growth peptide for guided bone regeneration.barrier membranes for guided bone regeneration (gbr) mainly promote mechanical maintenance of bone defect space and induce osteopromotion. additionally, biopolymer-based membranes may provide greater bioactivity and biocompatibility due to their similarity to extracellular matrix (ecm). in this study, biopolymers-based membranes from bacterial cellulose (bc) and collagen (col) associated with osteogenic growth peptide (ogp(10-14)) were evaluated to determine in vitro osteoinductive potential in ...201829363620
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