Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| brasilidine a, a new cytotoxic isonitrile-containing indole alkaloid from the actinomycete nocardia brasiliensis. | 1997 | 9249977 | |
| brasiliquinones a, b and c, new benz[alpha]anthraquinone antibiotics from nocardia brasiliensis. i. producing strain, isolation and biological activities of the antibiotics. | new benz[alpha]anthraquinone antibiotics (brasiliquinones a, b and c) with an ethyl group at c-3 were isolated. the producer was identified as nocardia brasiliensis. the antibiotics were active against gram-positive bacteria including mycobacterium sp., but not active against gram-negative bacteria or fungi. they were also active against multiple drug-resistant p388/adr tumor cells. | 1997 | 9066761 |
| a case of disseminated infection with nocardia brasiliensis in a lung transplant recipient. | infection with nocardia species is an increasingly recognized complication of solid organ transplantation. nocardia asteroides accounts for most transplant-related nocardiosis, while nocardia brasiliensis rarely causes infection in organ transplant recipients. | 1997 | 9133485 |
| nocardia brasiliensis keratitis successfully treated with therapeutic lamellar keratectomy. | a 36-year-old man sustained an indolent keratitis following a minor corneal trauma. nocardia brasiliensis was isolated from cultures of the corneal scrapings. fortified topical antibiotics, based on in vitro drug sensitivity testing, were intensively applied for weeks without clinical improvement. the patient underwent therapeutic lamellar keratectomy, which led to a rapid and complete resolution. the site of the keratectomy reepithelialized within 2 days and became a faint subepithelial haze th ... | 1996 | 8925664 |
| activities of the glycylcyclines n,n-dimethylglycylamido-minocycline and n,n-dimethylglycylamido-6-demethyl-6-deoxytetracycline against nocardia spp. and tetracycline-resistant isolates of rapidly growing mycobacteria. | susceptibilities to the new semisynthetic tetracycline (tet) compounds n,n-dimethylglycylamido-minocycline (dmg-mino) and n,n-dimethylglycylamido-6-demethyl-6-deoxytetracycline (dmg-dmdot) were compared with those to doxycycline, minocycline, and tet for 198 tet-resistant (tetr) and 33 tet-susceptible (tets) clinical isolates of rapidly growing mycobacteria (rgm) including the mycobacterium fortuitum group, mycobacterium abscessus, mycobacterium chelonae, and mycobacterium mucogenicum and 68 iso ... | 1996 | 8849243 |
| [mycetoma: report of 3 cases in falcón state, venezuela]. | this is a report of three cases of mycetome studied in our laboratory during the last four years. we also informed about the evolution of the first case produced by pyrenochaeta romeroi nova species reported by borelli in 1959. all the patients were farmer men, 18, 42 and 54 years old, from the semiarid and subhumid zones of falcon state, located on the northwest region of venezuela. clinically, all patients presented the mycetome syndrome (subcutaneous edema, sinus tract and "granules"), with a ... | 1996 | 8920032 |
| role of passive humoral immunity in experimental mycetoma by nocardia brasiliensis. | 1996 | 8993374 | |
| a case of lymphocutaneous nocardiosis with a review of lymphocutaneous nocardiosis reported in japan. | an 82-year-old japanese male developed nodules and ulcers along the lymphatics after a fall in the garden of his house resulting in injuries to the dorsum of his left hand which lasted for 3 months. nocardia brasiliensis was isolated from a nodule, supporting a diagnosis of the lymphocutaneous type of nocardiosis. he had previously developed generalized bone metastasis from prostatic cancer, and his resulting depressed immunity might have played a part in the nocardiosis genesis. sixteen cases o ... | 1996 | 8839240 |
| a rapid and gentle method for isolation of genomic dna from pathogenic nocardia spp. | the lack of simple and efficient methods for extraction of dna from nocardia spp. has hampered molecular manipulation of the dna for diagnostic purposes. in the present study, a method for the rapid extraction of undegraded genomic nocardial dna was established. briefly, 14 pathogenic nocardia strains were grown at 37 degrees c for 3 to 5 days in sauton broth containing 0.05% tween 80. subsequently, the cultures were treated for 48 h with 1.2 mg of cycloserine per ml (final concentration). cells ... | 1996 | 8877144 |
| nocardia pseudobrasiliensis sp. nov., a new species of nocardia which groups bacterial strains previously identified as nocardia brasiliensis and associated with invasive diseases. | we studied five strains of a new nocardia taxon recently identified among nocardia brasiliensis strains associated with invasive diseases (r. j. wallace, jr., b. a. brown, z. blacklock, r. ulrich, k. jost, j. m. brown, m. m. mcneil, g. onyi, v. a. steingrube, and j. gibson, j. clin. microbiol. 33:1528-1533, 1995) to determine their taxonomic status. several characteristics of these organisms, including the presence of chemotype iv cell walls, nocardomycolic acids, a predominant menaquinone simil ... | 1996 | 8573505 |
| an acute nocardia brasiliensis infection of the hand: a case report. | 1996 | 8683074 | |
| a palmar chancre and multiple proximal erythematous nodules. nodular lymphangitis due to nocardia brasiliensis. | 1996 | 8712850 | |
| isolation and characterisation of nocardia from clinical specimens. | sixteen isolations of nocardia of which 12 were from pulmonary infections, one from wound infection, one from mycetoma and 2 from eye infections were studied from june, 1989 to may, 1990. the importance of gram's stain findings of primary smear is being highlighted. the nocardia species were identified utilising the morphological characters including acid fastness and cultural and biochemical characters. notable among the isolates were nocardia brasiliensis, one each from mycetoma and pulmonary ... | 1996 | 8810179 |
| brain abscess due to nocardia brasiliensis hematogenously spread from a pulmonary infection. | 1995 | 8562775 | |
| nocardia brasiliensis: in vitro and in vivo growth response to steroid sex hormones. | as actinomycetoma is more frequent in males than in females, the possibility that hormones might modify the nocardia brasiliensis growth and the course of experimental actinomycetoma was explored. five n. brasiliensis strains were grown on sabouraud agar containing estradiol, progesterone or testosterone, in 3 different concentrations. colony diameters were measured weekly for 7 weeks. n. brasiliensis strains were also grown in sabouraud broth containing hormones. glucose concentration was measu ... | 1995 | 8819830 |
| lymphocutaneous nocardia brasiliensis infection: a case report and review. | 1995 | 7566789 | |
| concurrent chromoblastomycosis caused by fonsecaea pedrosoi and actinomycetoma caused by nocardia brasiliensis. | chromoblastomycosis and mycetoma are chronic infections caused by the repeated traumatic inoculation of organisms into the skin and subcutaneous tissue. chromoblastomycosis is caused by several dematiaceous (pigmented) fungi, occurs in tropical regions, and usually affects the lower extremities. the lesions may be nodules, plaques, or tumorous masses. mycetomas are caused by either true fungi (eumycetes) or filamentous bacteria (actinomycetes); they also occur predominantly in tropical areas and ... | 1995 | 7829748 |
| new nocardia taxon among isolates of nocardia brasiliensis associated with invasive disease. | nocardia brasiliensis, the second most frequently isolated aerobic actinomycete in the clinical laboratory, is usually associated with localized cutaneous infections. however, 22% of 238 n. brasiliensis isolates from the united states and 12% of 66 isolates from queensland, australia, which had been collected over a 17-year period, were associated with extracutaneous and/or disseminated diseases. of the 62 invasive isolates, 37 (60%) were susceptible to ciprofloxacin and/or were susceptible to c ... | 1995 | 7650180 |
| unusually located lymphocutaneous nocardiosis caused by nocardia brasiliensis. | we report a patient with primary lymphocutaneous nocardia brasiliensis infection affecting the face and left arm. the mode of infection was via skin abrasions which occurred 2 weeks prior to the development of the skin lesions. treatment with intravenous minocycline for 4 weeks resulted in a cure. we also review 12 previously reported japanese cases of lymphocutaneous nocardiosis. | 1995 | 7748754 |
| lymphocutaneous nocardiosis with multiple subcutaneous nodules distributed over the extensor aspect of the forearm. report of a case. | we report a case of lymphocutaneous nocardiosis due to nocardia brasiliensis, marked by multiple subcutaneous nodules and abscesses on the extensor aspect of the left forearm in a 53-year-old woman with systemic lupus erythematosus. nine months before she was first examined, she had fallen on a concrete surface. a nodule had appeared 2 months later at the same site and had expanded and been followed by others, which finally covered most of the extensor aspect of the forearm. we speculated that t ... | 1994 | 7701876 |
| three new reduced anthracycline related compounds from pathogenic nocardia brasiliensis. | three new metabolites were isolated from a pathogenic bacterium, nocardia brasiliensis ifm 0075 strain, a producer of a new anthracycline antibiotic (so-075r1) and its mutant strain (ifm 0075-13-1). the structural studies showed that they are reduced anthracyline related compounds. some biosynthetic routes of these metabolites were discussed. | 1994 | 7928699 |
| lymphocutaneous nocardia brasiliensis infection transmitted via a cat scratch: a second case. | 1994 | 8038327 | |
| nodular lymphadenitis caused by nocardia brasiliensis. | 1994 | 8075295 | |
| enzyme-linked immunosorbent assay for serological diagnosis of nocardia brasiliensis and clinical correlation with mycetoma infections. | we previously identified three immunodominant antigens obtained from a nocardia brasiliensis cell extract and recognized by sera from mycetoma patients (m. c. salinas-carmona, l. vera, o. welsh, and m. rodríguez, zentralbl. bakteriol. 276:390-397, 1992). in the present work, we obtained a crude extract from a mass culture of n. brasiliensis hujeg-1 and purified two immunodominant antigens, the 26- and 24-kda proteins, by using simple physiochemical techniques. with these antigens, we developed a ... | 1993 | 8263174 |
| cervicofacial nocardiosis caused by nocardia brasiliensis in an adult. | 1993 | 8286649 | |
| inactivation of rifampin by nocardia brasiliensis. | rifampin was glycosylated by a pathogenic species of nocardia, i.e., nocardia brasiliensis. the structures of two glycosylated compounds (rip-1 and rip-2) isolated from the culture broth of the bacterium were determined to be 3-formyl-23-(o-[beta-d-glucopyranosyl])rifamycin sv and 23-(o-[beta-d-glucopyranosyl])rifampin, respectively. both compounds lacked antimicrobial activity against other gram-positive bacteria as well as the nocardia species. | 1993 | 8328779 |
| pc-766b, a new macrolide antibiotic produced by nocardia brasiliensis. ii. isolation, physico-chemical properties and structure elucidation. | a new macrolide antibiotic, pc-766b, was isolated from the cells of nocardia brasiliensis sc-4710 by acetone extraction, and purified by gel filtration, silica gel chromatography, hplc and tlc. the structure of pc-766b was determined by nmr spectral analysis to be a new class of the hygrolidin family antibiotics. pc-766b had a 16-membered macrocyclic lactone ring, a 6-membered hemiketal ring and a 2-deoxy-d-rhamnose moiety. dl-alpha-tocopherol, known as an antioxidant agent, significantly improv ... | 1993 | 8360110 |
| amoxicillin and clavulanic acid in the treatment of actinomycetoma. | mycetoma is a relatively frequent disease in tropical countries. drugs commonly used need a long period of treatment, and some cases are resistant to these drugs, especially those with bone or visceral involvement. the combination of amoxicillin-clavulanic acid has shown effectiveness against strains of nocardia brasiliensis in vitro. | 1993 | 8444539 |
| nodular lymphangitis: a distinctive but often unrecognized syndrome. | to describe nodular lymphangitis by reviewing the clinical and epidemiologic features of this disease with an emphasis on distinguishing specific etiologic agents. | 1993 | 8480962 |
| treatment of a nocardia brasiliensis mycetoma with sulfamethoxazole and trimethoprim, amikacin, and amoxicillin and clavulanate. | 1993 | 8481016 | |
| nocardiosis in renal transplant recipients undergoing immunosuppression with cyclosporine. | nine cases of nocardiosis were diagnosed among 1,255 renal transplant recipients given cyclosporine (csa)-prednisone for immunosuppression between august 1980 and march 1992 (incidence, 0.7%). of these nine patients presenting with nocardiosis 32-1,806 days after transplantation, eight had pulmonary involvement, two had skin manifestations (one with localized disease), and one had a cerebral abscess and a pleural effusion. all cases required aggressive diagnostic procedures. nocardia asteroides ... | 1993 | 8513056 |
| mycetoma: a retrospective study of 41 cases seen in são paulo, brazil, from 1978 to 1989. | clinical and epidemiological aspects of 41 cases of mycetoma seen in são paulo city from january 1978 to december 1989 are presented. twenty-eight cases (68%) were caused by actinomycetes, while 13 (32%) were caused by true fungi. in only 22 (78%) actinomycetoma cases was it possible to identify the agent. nocardia brasiliensis, by far the commonest actinomycete isolated, was responsible for 13 cases. among eumycetomata, madurella grisea was isolated from 3 cases, scedosporium apiospermum from 2 ... | 1993 | 8366881 |
| pc-766b, a new macrolide antibiotic produced by nocardia brasiliensis. i. taxonomy, fermentation and biological activity. | an actinomycete strain sc-4710, a new soil isolate, was found to produce a new macrolide antibiotic, pc-766b. chemotaxonomic analysis of the producing organism revealed that the cells of sc-4710 had type iv cell wall, type a whole cell sugar pattern, type pii phospholipids, menaquinone mk-8(h4), cellular fatty acids comprising straight-chain saturated, unsaturated and tuberculostearic acids, and mycolic acids. the strain was identified as nocardia brasiliensis (lindenberg) pinoy. the antibiotic, ... | 1993 | 8393851 |
| nocardia brasiliensis liver abscesses in an aids patient: imaging findings. | 1993 | 8456695 | |
| nocardia brasiliensis soft tissue infection in an immunocompromised host. | 1992 | 1641216 | |
| isolation and purification of two immunodominant antigens from nocardia brasiliensis. | two immunogenic proteins from a crude extract of nocardia brasiliensis were purified to homogeneity. a 61-kda protein (p61) was isolated from a 50% ammonium sulfate precipitate in two steps. initially, p61 was obtained by electroelution in a 10% nondenatured preparative polyacrylamide gel electrophoresis (page). in a second step, the eluate from the nondenatured gel was run in a 12% sodium dodecyl sulfate (sds) preparative polyacrylamide gel. after elution, a single band was demonstrated by sds- ... | 1992 | 1583118 |
| so-75r1, a new mutactimycin derivative produced by nocardia brasiliensis. | 1992 | 1500368 | |
| sf2457, a new antibiotic related to amicetin. | a novel nucleoside antibiotic, sf2457, was isolated from the fermentation broth of nocardia brasiliensis sf2457. the structure of sf2457 was determined by degradation studies using alkaline hydrolysis and methanolysis. sf2457 is closely related to the amicetin group antibiotics. the antibiotic exhibited inhibitory activity against gram-positive and gram-negative bacteria. | 1992 | 1500349 |
| preseptal cellulitis caused by nocardia brasiliensis. | 1992 | 1524136 | |
| properties of a partially purified acid phosphatase from pathogenic nocardia brasiliensis. | like many other bacteria, nocardia sp. possess acid phosphatase activity. in n. brasiliensis, a human and animal pathogen, this activity was resolved into two enzyme forms by native gel electrophoresis. one (isozyme i) was partially purified and characterized. it exhibited an estimated molecular weight on sds-page of 50 kda, a ph optimum of 5.2, and a km value of 1.25 mm for p-nitrophenylphosphate. the n. brasiliensis enzyme was stable at 4 degrees c for at least 24 h, but readily inactivated at ... | 1992 | 1435947 |
| cutaneous nocardiosis associated with insect bites. | we report the first case of cutaneous nocardiosis associated with insect bites. the patient received these insect bites while camping a few days before he presented to the emergency room. the patient was a healthy twenty-six-year-old man, who was asplenic as a result of a motor vehicle accident. he presented to the emergency room with fever, multiple insect bites to his left lower extremity with pustules, lymphangitis, and left inguinal adenopathy. he was hospitalized but his condition failed to ... | 1992 | 1424798 |
| [epidemiology of mycetoma in mexico: study of 2105 cases]. | a survey was carried out in mexico to determine the incidence and epidemiological characteristics of mycetoma. data was collected from a total of 2105 cases of mycetoma throughout a 30 year period (1956-1985), with an average incidence of 70 cases per year. results showed a sex distribution of 76.1% male and 23.9% females. age distribution indicated a 35% between 16 to 30 and 23% between 31 to 40 year old population. most cases occurred in land-workers (60.2%) and in housewives with rural reside ... | 1992 | 1308000 |
| lymphocutaneous nocardia brasiliensis infection acquired from a cat scratch: case report and review. | nocardia brasiliensis is a bacterium that is most commonly found in the soil. traumatic inoculation of n. brasiliensis into the skin is the most typical mode of acquisition of infection due to this organism. to the best of my knowledge, i report the first case of lymphocutaneous n. brasiliensis disease from a penetrating cat scratch of the skin, thereby establishing cats as vehicles for the transmission of this infection. treatment with penicillin produced a rapid resolution of all signs and sym ... | 1992 | 1420688 |
| review of nocardial infections in france 1987 to 1990. | on the basis of the numbers of nocardia strains referred to the national reference center for mycoses and antifungal agents (nrc), institut pasteur, paris, in the period from 1987 to 1990, it was estimated that between 150 and 250 cases of nocardiosis are diagnosed in france each year. a total of 63 clinical isolates were referred to the nrc and identified as nocardia asteroides (66.7%), nocardia farcinica (23.8%), nocardia brasiliensis (3.2%), nocardia otitidiscaviarum (4.8%) and nocardia carne ... | 1992 | 1425729 |
| the producer and biological activities of so-75r1, a new mutactimycin group antibiotic [corrected]. | the producer of so-75r1, a new anthracycline group antibiotic was identified as nocardia brasiliensis. so-75r1 was active against gram-positive bacteria, but not active against gram-negative bacteria or fungi. all tested nocardia brasiliensis strains as well as the producer itself were resistant to so-75r1, although four other pathogenic nocardia, i.e. n. asteroides, n. nova, n. farcinica and n. otitidiscaviarum were sensitive [corrected]. | 1992 | 1490875 |
| nocardia brasiliensis meningitis. | 1992 | 1494536 | |
| tumor necrosis factor and macrophage activation are important in clearance of nocardia brasiliensis from the livers and spleens of mice. | the roles of tumor necrosis factor (tnf) and macrophage activation in clearance of nocardia brasiliensis from balb/c mouse livers and spleens were evaluated. tnf activity was detectable in sera from animals at all stages of infection. treatment of infected mice with an antiserum against tnf significantly enhanced the experimental infection as judged by enumeration of cfu in the spleens and livers of infected mice. in another set of experiments, a population of activated macrophages from the peri ... | 1992 | 1500164 |
| in-vitro activity of new carbapenem antibiotics: comparative studies with meropenem, l-627 and imipenem against pathogenic nocardia spp. | mics of two new carbapenems, meropenem and l-627, and imipenem were determined against 98 strains of the nocardia asteroides group (i.e. n. asteroides sensu stricto, nocardia farcinica and nocardia nova), 46 strains of nocardia brasiliensis and 17 strains of nocardia otitidiscaviarum. meropenem and l-627 were less active against the n. asteroides group than imipenem. among the three species of the n. asteroides group, n. nova was the most sensitive to all the carbapenems. meropenem was more acti ... | 1992 | 1506332 |
| disseminated nocardia brasiliensis infection with septic arthritis. | an unusual case of disseminated nocardia brasiliensis infection is presented. the patient, who had been receiving chronic dexamethasone therapy for 4 years, had pneumonia and septic arthritis of the left knee due to n. brasiliensis. to our knowledge, this is the first report from the united states of a synovial joint infection with this organism. disseminated disease due to n. brasiliensis is infrequently reported; it is most often seen in the immunocompromised patient and is often unresponsive ... | 1992 | 1520795 |
| mini-mycetoma due to nocardia brasiliensis. | 1992 | 1568813 | |
| nocardia brasiliensis infection in patients with aids. | 1992 | 1576299 | |
| antibody response to nocardia brasiliensis antigens in man. | a crude extract from n. brasiliensis cells grown in brain heart infusion culture was analyzed. it showed a complex mixture of at least 37 bands when resolved with the discontinuous buffer system of laemmli in a gradient sds-page. western blot analysis of 16 sera from n. brasiliensis-infected individuals always showed the recognition of six bands of 61, 49, 45, 42, 26, and 24 kilodaltons (kda). some other bands also reacted but with less intensity. sera from tuberculosis and leprosy patients reac ... | 1992 | 1576408 |
| community acquired pneumonia: aetiology and prognostic index evaluation. | a 10 month prospective study of all adults admitted to waikato hospital with community acquired pneumonia was performed to assess aetiology, mortality, hospital stay, and the value of a prognostic index based on that obtained from a british thoracic society study. the 92 patients in the survey had a mean age of 56 (range 13-97) years. a microbiological diagnosis was established in 72%; streptococcus pneumoniae (33%), mycoplasma pneumoniae (18%), and influenza a virus (8%) were the most common mi ... | 1991 | 1907034 |
| disseminated nocardia brasiliensis infection: an unusual complication of immunosuppressive treatment for childhood dermatomyositis. | the use of steroids combined with cytotoxic drugs has increased in the last decade. the concomitant increase of opportunistic infections has contributed significantly to morbidity and mortality of patients treated with immunosuppressive agents. we describe a child with dermatomyositis who developed disseminated nocardia brasiliensis infection while receiving steroids and methotrexate. infectious etiology was established by gram stain. the patient was treated successfully. disseminated nocardia b ... | 1991 | 1941833 |
| acid and alkali as aids in differentiation of pathogenic nocardia and for their isolation from clinical specimens. | the tolerance of nocardia brasiliensis, nocardia asteroides and nocardia caviae to different concentrations of acids and alkalis was studied in this work. the purpose was to determine their use: (a) in the differentiation of species; (b) for decontamination of clinical materials during the isolation of pathogenic nocardia. the results showed (1) that both 2 m nh3 and 0.05 m h2so4 solutions are useful for differentiating species. they can also be used as a complementary method for identification. ... | 1991 | 2067559 |
| acquired resistance of nocardia brasiliensis to clavulanic acid related to a change in beta-lactamase following therapy with amoxicillin-clavulanic acid. | previous studies have demonstrated that nocardia brasiliensis is susceptible to amoxicillin-clavulanic acid and that its beta-lactamases are inhibited in vitro by clavulanic acid. a cardiac transplant patient with disseminated infection caused by n. brasiliensis was treated with this drug combination with good response, but relapsed while still on therapy. the relapse isolate was found to be identical to the initial isolate by using genomic dna restriction fragment patterns obtained by pulsed fi ... | 1991 | 2039203 |
| beneficial effects of hyperbaric oxygen therapy in nocardia brasiliensis soft-tissue infection. | to report the success of hyperbaric oxygen therapy in the treatment of nocardia brasiliensis mycetoma. we believe this to be only the second report in the medical literature of hyperbaric oxygen therapy used in the therapy of nocardial disease. | 1991 | 1857290 |
| acute primary cutaneous nocardiosis. | an acute localized, purulent skin lesion developed on the right knee of an 8-year-old girl and was subsequently diagnosed as a primary cutaneous nocardia brasiliensis infection. it was soon accompanied by intense lymphangitis and regional adenopathy. the patient had a history of a minor abrasion contaminated by soil at the site of infection 8 days before the infection became evident. the infection was successfully treated with a combination of minocycline and dapsone. | 1990 | 2394860 |
| comparison of antigens from agents of actinomycetoma by immunodiffusion and electrophoresis procedures. | antigenic extracts were prepared from culture filtrates of the principal agents known to cause actinomycetoma, namely actinomadura madurae, actinomadura pelletieri, nocardia asteroides, nocardia brasiliensis, nocardia otitidis-caviarum, and streptomyces somaliensis. these antigenic preparations were compared by immunodiffusion (id), counterimmunoelectrophoresis (cie), line immunoelectrophoresis (lie) and rocket line immunoelectrophoresis (rlie), with rabbit antisera prepared against each of the ... | 1990 | 2126557 |
| use of partially purified 54-kilodalton antigen for diagnosis of nocardiosis by western blot (immunoblot) assay. | a western blot (immunoblot) assay is presented for the diagnosis of nocardiosis with a specific immunodominant 54-kilodalton (kda) antigen purified from a culture filtrate of nocardia asteroides by immunoaffinity chromatography. the chromatography column was prepared with immunoglobulin g obtained from sera from patients with lepromatous leprosy. unbound solutes consisted of specific, partially purified n. asteroides antigens, primarily a 54-kda band, accompanied by two others of 31 and 62 kda. ... | 1990 | 2179262 |
| cultivation of a nocardioform acid-fast chemoautotrophic bacterium from armadillo tissues infected with mycobacterium leprae. | a nocardioform bacterium was isolated from the spleen tissue of an armadillo infected with m. leprae and easily propagated in pure culture in mineral salt medium supplemented with only simple c and n sources (e.g., liquid paraffin, tetradecane, ammonium salts, urea, asparagine, gelatin, xanthin, hypoxanthin etc.). complex organic substances, e.g., tyrosin, casein, peptone, meat extract, egg proteins, serum, blood, yeast extract as well as medium 199, did not support the growth of this organism. ... | 1990 | 2188909 |
| nocardia brasiliensis peritonitis in a patient with aids. | 1990 | 2220750 | |
| comparison of species distribution and antimicrobial susceptibility of aerobic actinomycetes from clinical specimens. | to compare the species distribution and antimicrobial susceptibility of aerobic actinomycetes, we evaluated 366 isolates referred to the centers for disease control from october 1985 through february 1988. we used conventional biochemical tests to identify the various species. four species accounted for 191 (52%) of aerobic actinomycete isolates: nocardia asteroides (98 isolates), actinomadura madurae (42 isolates), streptomyces griseus (28 isolates), and nocardia brasiliensis (23 isolates). spu ... | 1990 | 2237117 |
| pulmonary cryptococcus neoformans and disseminated nocardia brasiliensis in an immunocompromised host. case report. | 1990 | 2342607 | |
| nocardia brasiliensis leg ulcer in a child. | 1990 | 2352823 | |
| monoclonal antibodies to nocardia asteroides and nocardia brasiliensis antigens. | nocardia asteroides and nocardia brasiliensis whole-cell extracts were used as antigens to generate monoclonal antibodies (mabs). six stable hybrid cell lines secreting anti-nocardia spp. mabs were obtained. these were characterized by enzyme-linked immunosorbent assay, western blot (immunoblot), and immunofluorescence assay. although all the mabs exhibited different degrees of cross-reactivity with n. asteroides and n. brasiliensis antigens as well as with culture-filtrate antigens from mycobac ... | 1990 | 2405017 |
| nocardia brasiliensis cellulitis in a heart transplant patient. | three months after undergoing heart transplantation, a 55-year-old man presented with n. brasiliensis cellulitis resulting from a splinter wound acquired during yard work. surgical débridement was necessary before the infection responded to medical treatment. although pulmonary nocardiosis is a well-documented complication of immunosuppressive therapy, this is the 1st report of a nocardial infection associated with primary skin involvement in a heart transplant patient. | 1990 | 15227399 |
| the efficiency of 1 m nh4cl and 2 m nacl for the isolation of pathogenic nocardia from soil. | the present paper reports an improvement to the classical method of the paraffin bait, by the usage of 1 m nh4cl or 2 m nacl to eliminate contaminant microflora of soil. the purpose is to introduce a change in the paraffin bait method in order to reduce time required to isolate pathogenic strains of nocardia from their natural sources. for this study three main criteria were used: a) determination of the inhibitory effect of different concentrations of salts on soil microflora; b) the tolerance ... | 1989 | 2594047 |
| mycetoma due to nocardia brasiliensis: first case report from the union territory of delhi. | the first case of mycetoma caused by nocardia brasiliensis from the union territory of delhi is reported. the patient, a permanent resident of the union territory of delhi, acquired the disease 10 years ago following an accidental injury to his right hand. the diagnosis of the case was made on the basis of demonstration of the grains in direct microscopy, isolation of the organism in culture directly from the grains, identifying the organism by the conventional tests and through histopathology o ... | 1989 | 2608095 |
| cutaneous abscess caused by nocardia brasiliensis: report of a case. | we report a case of cutaneous nocardia brasiliensis infection. the patient had received radiotherapy and anti-neoplastic chemotherapy for epidermoid carcinoma of the left sphenoid sinus with bone destruction. he developed fever and an ulcer on the dorsal medial surface of the left hand after an intravenous infusion of chemotherapeutic agents in the same site 3 days earlier. needle aspiration of the abscess disclosed polymorphonuclear leukocytes, and a partially acid-fast, gram-positive filamento ... | 1989 | 2636252 |
| [surgical treatment of mycetoma located in the face]. | the first case described in mexico, was studied by cícero in 1900 and 1911 ocaranza, in sonora, reports some cases, pointing out that the first known case dates back to 1874. in usa gonzález ochoa identifies the causative agent of the cases he studied, as the same identified in usa, but he calls attention to the fact that it has already been described under the name of actinomyces brasiliensis, finally, taxonomically it is included among the nocardias. in mexico the micetoma is caused in 90% of ... | 1989 | 2666793 |
| [in vitro susceptibility of pathogenic nocardia to beta-lactam antibiotics, especially imipenem, a carbapenem antibiotic]. | in vitro antibacterial activity of 30 beta-lactam antibiotics including 2 beta-lactamase inhibitors (clavulanic acid and sulbactam) against 2 major pathogenic nocardia, i.e. nocardia asteroides group and nocardia brasiliensis was studied. among the antibiotics tested, a newly developed carbapenem antibiotic, imipenem (ipm), was found to be the most active, followed by oxacephem group antibiotic flomoxef (fmox). ipm exhibited activity against only n. asteroides group (n. asteroides, nocardia farc ... | 1989 | 2695658 |
| physiological and pathogenic characteristics of nocardia brasiliensis isolated from human mycetomas. | a previous analysis of the physiological properties of nocardia brasiliensis strains isolated from soil of tucumán proves that non-pathogenic strains have a different behaviour pattern from the pathogenic strains. in the present paper, 16 nocardia brasiliensis strains isolated from human mycetomas were studied in the same way. the object is to determine if any of the nocardia brasiliensis present in soil can produce human mycetomas. the macro and micromorphological, biochemical (17 tests), physi ... | 1989 | 2747785 |
| [disseminated nocardiosis due to nocardia brasiliensis in an ambulatory patient]. | we report the case of a 76-year-old man with generalized nocardiosis. the microbiologic pattern, the different clinical manifestations and the treatment of nocardiosis are discussed in general. in the particular case of our patient the disease manifested itself primarily as a subcutaneous abscess, a metastasis secondary to pulmonary nocardiosis. the disease was caused by a nocardia brasiliensis, which is rarely seen in europe and which does not usually cause a generalized form of nocardiosis. | 1989 | 2756262 |
| in vitro susceptibilities of nocardia species to newer antimicrobial agents. | the in vitro activities of various quinolones, two newer cephalosporins, and imipenem against 23 strains of nocardia asteroides, 4 strains of nocardia brasiliensis, and 4 strains of nocardia caviae were determined by an agar dilution method. pd-117558, a newer carboxyquinolone, and imipenem were the most active agents tested, inhibiting 90% of n. asteroides isolates at an mic of 2 micrograms/ml. of the 23 strains of n. asteroides, 15 were susceptible to cefpirome and 10 were susceptible to cipro ... | 1988 | 3190193 |
| acid phosphatase activity in nocardia brasiliensis and nocardia asteroides. | nocardia asteroides and n. brasiliensis strains were found to possess acid phosphatase activity. this enzyme was found to be cell-associated and its activity paralleled the cell mass increase seen during the nocardia growth cycle. of the strains tested, n. brasiliensis exhibited the highest enzymatic activity. implications of these findings are related to current evidence which indicates that other microbial acid phosphatases may constitute potential pathogenic factors for humans. | 1988 | 3287423 |
| primary lymphocutaneous nocardia brasiliensis infection: three case reports and a review of the literature. | the occurrence of human nocardiosis is increasing in both immunocompetent as well as immunosuppressed patients. we report three rare cases of primary lymphocutaneous nocardia brasiliensis infection. the mode of inoculation in each case was that of a puncture wound that occurred 1-3 wk prior to the development of the clinically apparent infections. the original clinical diagnosis was erroneous in each case. a review of 16 previously reported cases is presented as well as a discussion of appropria ... | 1988 | 3066569 |
| beta-lactam resistance in nocardia brasiliensis is mediated by beta-lactamase and reversed in the presence of clavulanic acid. | forty clinical isolates and the type strain of nocardia brasiliensis were screened for susceptibility to 20 beta-lactams. isolates exhibited a single pattern of resistance, with large zones of inhibition by disk diffusion and low mics by broth and agar dilutions only to cefotaxime, ceftriaxone, ceftizoxime, augmentin, and timentin. all strains produced beta-lactamase, with five different enzyme patterns by isoelectric focusing. despite the differences in their isoelectric points, the enzymes had ... | 1987 | 3500241 |
| detection of metabolites by frequency-pulsed electron capture gas-liquid chromatography in serum and cerebrospinal fluid of a patient with nocardia infection. | serum (sr) and cerebrospinal fluid (csf) from a patient suspected of having tuberculous meningitis were submitted to our laboratory for analysis by frequency-pulsed electron capture gas-liquid chromatography (fpec glc). the samples were tested for the presence of carboxylic acids, alcohols, hydroxy acids, and amines by methods described previously (c. c. alley, j. b. brooks, and d. s. kellogg, jr., j. clin. microbiol. 9:97-102, 1977; j. b. brooks, c. c. alley, and j. a. liddle, anal. chem. 46:19 ... | 1987 | 3818936 |
| [cerebral manifestation of nocardia brasiliensis infection]. | 1987 | 3031771 | |
| mycetoma due to nocardia caviae. | mycetoma is the most frequent deep mycosis in mexico and is caused by nocardia brasiliensis in 86% of the cases. two cases of mycetoma due to nocardia caviae, the first in mexico, are reported. the strains were identified by their biochemical properties according to the criteria of gordon and mihm (1962). few cases of mycetoma caused by this actinomycete have been reported in the world. one of our cases was unusual: occurring on the trunk as a tumor and diagnosed by finding the "grains" on histo ... | 1987 | 3494691 |
| intracerebral nocardia brasiliensis infection. | case report about cerebral infection with the species nocardia brasiliensis in a not immunocompromised host. diagnosis, treatment and neuroradiological findings are shown and compared with current studies. | 1987 | 3506148 |
| studies on the pathogenesis of actinomycotic mycetoma in animals injected with fractions isolated from nocardia brasiliensis. | in the present study the participation was evaluated of isolated fractions of nocardia brasiliensis in the genesis of the inflammatory response observed in actinomycotic mycetoma. subcutaneous injection in mice of a suspension containing a polysaccharide fraction f1 obtained by treating cell walls with sodium hydroxide induced an inflammatory response at the inoculation site which was characterized by a large influx of polymorphonuclear (pmn) and mononuclear (mn) leucocytes between the 2nd and 4 ... | 1987 | 3814496 |
| relationships between the physiological characteristics and pathogenicity of nocardia brasiliensis. | the analysis of 19 physiological properties of 28 strains of nocardia brasiliensis isolated from soil reveal differences which could be of great value in distinguishing pathogenic from nonpathogenic strains. | 1987 | 3587331 |
| lymphocutaneous nocardiosis caused by nocardia asteroides. case report and literature review. | a 22-year-old man developed erythematous nodules and an ulcer mimicking sporotrichosis on his right hand and forearm, which was subsequently diagnosed as lymphocutaneous nocardiosis caused by nocardia asteroides. to our knowledge, 21 cases of lymphocutaneous nocardiosis have been reported, with the majority of those cases, except for a few that remain uncertain, being due to nocardia brasiliensis. the case reported herein, the first known definitive case caused by n asteroides (to our knowledge) ... | 1986 | 3532961 |
| mouse toxicity induced by lipids and cell walls isolated from actinomycetes. | the possibility was examined that the toxicity induced in mice by actinomadura madurae, 'streptomyces pelletieri' and nocardia brasiliensis was due to lipid and cell-wall constituents. mice were inoculated intraperitoneally with heat-killed bacteria, lipid extracts and cell-wall preparations emulsified in mineral oil: toxicity was evaluated by recording weight loss and deaths. killed cells and cell-wall preparations of all three actinomycetes produced a pronounced loss of body weight, tissue nec ... | 1986 | 3794660 |
| disseminated nocardia brasiliensis infection following cryptococcal disease. | nocardiosis is an increasing clinical problem, especially in immunocompromised patients. the offending species is almost always nocardia asteroides. cryptococcosis is also an increasing problem in the immunosuppressed. we describe a patient with probable disseminated cryptococcosis followed by disseminated nocardia brasiliensis infection. only eight patients with disseminated n brasiliensis infection have been described, to our knowledge, in the united states. | 1986 | 3767404 |
| nocardia brasiliensis skin infections. | nocardia brasiliensis skin infections were diagnosed in three patients (two with mycetoma and one with lymphocutaneous syndrome) in our hospital during the last 6 years. the mycetomas were detected in otherwise healthy yemenite immigrants who had acquired their infection while in yemen. the patient with the lymphocutaneous syndrome--a man with well-controlled diabetes mellitus--acquired his illness in israel. n. brasiliensis appears to be more common in our region than previously believed. this ... | 1986 | 3744789 |
| primary lymphocutaneous nocardia brasiliensis infection. | we report a rare case of primary lymphocutaneous nocardia brasiliensis infection occurring in an elderly diabetic man maintained on long-term therapy with prednisone. the mode of inoculation was that of a puncture wound caused by a contaminated needle that occurred one month prior to the development of the clinically apparent infection. the course of this patient's infection was protracted and required two surgical procedures and several months of antibiotic therapy. a review of 15 previously re ... | 1986 | 3767403 |
| [high-dosage cotrimoxazole therapy of disseminated nocardia brasiliensis infection]. | after a scraping injury to the skin a 47-year-old man developed a generalized nocardia brasiliensis infection with cutaneous, pulmonary and cerebral dissemination. there was no predisposing underlying illness. high-dosage cotrimoxazol and short-term intrathecal and systemic gentamycin administration achieved extensive healing. this form of treatment would thus seem capable of reversing the otherwise poor prognosis of generalized n. brasiliensis infection. | 1986 | 3484699 |
| subcutaneous abscesses caused by nocardia brasiliensis complicated by malignant lymphoma. a survey of cutaneous nocardiosis reported in japan. | a 47-year-old japanese man suffering from t-cell leukemia was examined for multiple subcutaneous abscesses followed to abrasion wound on his right knee. the causative organism was clustered, fine-branched filaments in pus aspirated from the lesions, identified as nocardia brasiliensis. most of the lesions regressed from the combined therapy of sulfamethoxazole and trimethoprim, leaving an ulcer on the patient's left leg. the nocardiosis cases in japan until 1984, including this one, were briefly ... | 1985 | 3877005 |
| septic arthritis due to nocardia brasiliensis. | 1985 | 3910830 | |
| the clinical spectrum of nocardia brasiliensis infection in the united states. | seven cases of infection due to nocardia brasiliensis were identified over a 13-year period at duke university medical center, durham, north carolina. these seven cases and a review of 55 cases in the literature reported from the united states show that n. brasiliensis can cause a wide spectrum of disease. forty-six of the 62 patients had disease of skin and soft tissues. cutaneous manifestations included cellulitis, pustules, ulcerations, pyoderma, subcutaneous abscesses, a lymphocutaneous synd ... | 1984 | 6374833 |
| purification and partial characterization of a nocardia brasiliensis extracellular protease. | nocardia brasiliensis possess proteolytic activities that can be readily detected in a variety of media. in a modified formulation of a growth medium originally used for streptomyces aureofaciens, n. brasiliensis was found to secrete proteolytic enzymes, one of which was capable of hydrolyzing casein. this enzyme was purified to homogeneity from cell-free culture filtrates of n. brasiliensis. the purification procedure included ion-exchange chromatography on carboxymethyl-sepharose, gel filtrati ... | 1984 | 6363390 |
| nocardia brasiliensis lymphocutaneous syndrome in a patient with lymphosarcoma. | 1984 | 6548715 | |
| preliminary evaluation of a passive hemagglutination assay and enzyme-linked immunosorbent assay for actinomycetoma caused by nocardia brasiliensis. | 1984 | 6368227 | |
| disseminated cutaneous nocardia brasiliensis infection. | nocardia brasiliensis is an uncommon pathogen in the united states despite its presence in soil samples. it is most frequently seen in patients who are immunosuppressed, but can occur in the immunocompetent host also. usually in a healthy host the infection is localized to one area of the body. disseminated infection was diagnosed in a healthy child who recovered fully after initiation of oral sulfonamide therapy. we suspect that the source was soil to which the patient was exposed during a fami ... | 1984 | 6504778 |
| failure of sulfonamides and trimethoprim in the treatment of nocardiosis. | an immunocompromised patient with nocardia brasiliensis pneumonia and empyema acquired disseminated disease due to nocardia asteroides and died. the treatment of choice for pulmonary or disseminated nocardiosis is 6 to 12 g/day of sulfisoxazole (or adjusted dosage to achieve a serum level of 100 to 150 mg/l) continued for six to 18 months. combination therapy may be beneficial in selected patients; if trimethoprim therapy is used with sulfonamides, higher than usual doses of trimethoprim may be ... | 1983 | 6337576 |
| sensitivity to capreomycin and prothionamide in strains of mycobacterium, nocardia, rhodococcus, and related taxa for taxonomical purposes. | sensitivity to capreomycin and to prothionamide was analysed for 150 strains belonging to the genera mycobacterium, nocardia, rhodococcus, and related taxa. the analyses showed, e.g., that strains of mycobacterium chelonei and nocardia brasiliensis were more resistant to capreomycin than the other strains tested and that m. farcinogenes differed from m. senegalense concerning sensitivity to this drug. the analysis showed, furthermore, that strains of mycobacterium differ from those of nocardia, ... | 1983 | 6196927 |
| immunoglobulin and complement in tissues of mice infected with nocardia brasiliensis. | two weeks after mice had been infected in the footpad with cells of nocardia brasiliensis, immunoglobulin and c3 deposits were observed in tissue from the inoculation site. both immunoglobulin and c3 were found in the actinomycotic granules that characterize the mycetoma and in the surrounding inflammatory zones, in which plasma cells were also present. although anti-n. brasiliensis specificity was evidenced at 14 days postinfection in an eluate of infected tissue by an immunoenzymatic assay, no ... | 1983 | 6852920 |